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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs10223710
log Bayes Factor = 20.423
Chromosome 6   position 32,218,681  (GRCh37) Explore rs10223710 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E10.9 Without complications
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.000 1.000
E03 Other hypothyroidism
0.000 0.001 0.999
E03.9 Hypothyroidism, unspecified
0.000 0.001 0.999
L40.9 Psoriasis, unspecified
0.000 0.002 0.998
E10.1 With ketoacidosis
0.000 0.004 0.996
L40 Psoriasis
0.000 0.011 0.989
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.012 0.988
E27 Other disorders of adrenal gland
0.000 0.023 0.977
G35 Multiple sclerosis
0.000 0.023 0.977
H36.0 Diabetic retinopathy
0.000 0.025 0.975
E27.1 Primary adrenocortical insufficiency
0.000 0.025 0.975
E20-E35 Disorders of other endocrine glands
0.000 0.026 0.974
D50 Iron deficiency anaemia
0.000 0.030 0.970
D50-D53 Nutritional anaemias
0.000 0.030 0.970
H36 Retinal disorders in diseases classified elsewhere
0.000 0.031 0.969
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.000 0.035 0.965
H30-H36 Disorders of choroid and retina
0.000 0.036 0.964
Chapter VII Diseases of the eye and adnexa
0.000 0.038 0.962
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.042 0.958
D50.9 Iron deficiency anaemia, unspecified
0.000 0.048 0.952
D80-D89 Certain disorders involving the immune mechanism
0.000 0.048 0.952
D86 Sarcoidosis
0.000 0.050 0.950
H02 Other disorders of eyelid
0.000 0.052 0.948
H00-H06 Disorders of eyelid, lacrimal system and orbit
0.000 0.053 0.947
D50.8 Other iron deficiency anaemias
0.000 0.060 0.940
E05.9 Thyrotoxicosis, unspecified
0.000 0.060 0.940
H02.1 Ectropion of eyelid
0.000 0.062 0.938
D86.9 Sarcoidosis, unspecified
0.000 0.064 0.936
# Top node
0.000 0.065 0.935
H33 Retinal detachments and breaks
0.000 0.066 0.934
H46-H48 Disorders of optic nerve and visual pathways
0.000 0.069 0.931
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.073 0.927
G35-G37 Demyelinating diseases of the central nervous system
0.000 0.073 0.927
L40-L45 Papulosquamous disorders
0.000 0.075 0.924
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.077 0.923
E50-E64 Other nutritional deficiencies
0.000 0.078 0.922
H33.3 Retinal breaks without detachment
0.000 0.082 0.918
E14 Unspecified diabetes mellitus
0.000 0.084 0.916
H02.8 Other specified disorders of eyelid
0.000 0.085 0.915
Chapter XII Diseases of the skin and subcutaneous tissue
0.000 0.087 0.913
L40.0 Psoriasis vulgaris
0.000 0.088 0.912
C82.9 Follicular non-Hodgkin's lymphoma, unspecified
0.905 0.095 0.000
E06 Thyroiditis
0.000 0.104 0.896
Chapter VI Diseases of the nervous system
0.000 0.105 0.895
H46 Optic neuritis
0.000 0.107 0.893
E04 Other non-toxic goitre
0.000 0.117 0.883
E16 Other disorders of pancreatic internal secretion
0.000 0.132 0.868
E55 Vitamin D deficiency
0.000 0.137 0.863
D86.1 Sarcoidosis of lymph nodes
0.000 0.138 0.862
D51 Vitamin B12 deficiency anaemia
0.000 0.139 0.861
D50.0 Iron deficiency anaemia secondary to blood loss (chronic)
0.000 0.139 0.861
E10.2 With renal complications
0.000 0.142 0.858
E14.3 With ophthalmic complications
0.000 0.151 0.849
H33.4 Traction detachment of retina
0.000 0.153 0.847
C82 Follicular [nodular] non-Hodgkin's lymphoma
0.846 0.154 0.000
E10.0 With coma
0.000 0.155 0.845
L40.8 Other psoriasis
0.000 0.165 0.835
E16.2 Hypoglycaemia, unspecified
0.000 0.166 0.834
H02.5 Other disorders affecting eyelid function
0.000 0.167 0.833
L40.5 Arthropathic psoriasis
0.000 0.170 0.830
H15-H22 Disorders of sclera, cornea, iris and ciliary body
0.000 0.171 0.829
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.000 0.176 0.824
E55.9 Vitamin D deficiency, unspecified
0.000 0.180 0.820
D86.8 Sarcoidosis of other and combined sites
0.000 0.182 0.818
E06.3 Autoimmune thyroiditis
0.000 0.184 0.816
E27.8 Other specified disorders of adrenal gland
0.000 0.184 0.816
D52 Folate deficiency anaemia
0.000 0.198 0.802
E07 Other disorders of thyroid
0.000 0.198 0.801
D51.9 Vitamin B12 deficiency anaemia, unspecified
0.000 0.203 0.797
E70-E90 Metabolic disorders
0.000 0.206 0.794
H49-H52 Disorders of ocular muscles, binocular movement, accommodation and refraction
0.000 0.206 0.794
H20 Iridocyclitis
0.000 0.207 0.793
D89 Other disorders involving the immune mechanism, not elsewhere classified
0.000 0.208 0.792
D68 Other coagulation defects
0.000 0.222 0.778
H47 Other disorders of optic [2nd] nerve and visual pathways
0.000 0.224 0.776
H02.9 Disorder of eyelid, unspecified
0.000 0.228 0.772
E53 Deficiency of other B group vitamins
0.000 0.230 0.770
H33.2 Serous retinal detachment
0.000 0.232 0.768
E86 Volume depletion
0.000 0.232 0.768
C82.0 Small cleaved cell, follicular
0.763 0.237 0.000
H02.2 Lagophthalmos
0.000 0.241 0.759
E10.5 With peripheral circulatory complications
0.000 0.241 0.759
C82.1 Mixed small cleaved and large cell, follicular
0.753 0.247 0.000
E14.9 Without complications
0.000 0.247 0.753
E04.0 Non-toxic diffuse goitre
0.000 0.251 0.749
E04.9 Non-toxic goitre, unspecified
0.000 0.251 0.749
L10-L14 Bullous disorders
0.000 0.252 0.748
E27.9 Disorder of adrenal gland, unspecified
0.000 0.258 0.741
L20-L30 Dermatitis and eczema
0.000 0.261 0.739
E27.2 Addisonian crisis
0.000 0.261 0.739
H20.0 Acute and subacute iridocyclitis
0.000 0.262 0.738
H10-H13 Disorders of conjunctiva
0.000 0.264 0.736
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.266 0.734
E04.2 Non-toxic multinodular goitre
0.000 0.266 0.734
E11 Non-insulin-dependent diabetes mellitus
0.000 0.268 0.732
E10.4 With neurological complications
0.000 0.268 0.732
D53 Other nutritional anaemias
0.000 0.275 0.725
E10.6 With other specified complications
0.000 0.276 0.724
C82.3 Follicular lymphoma grade IIIa
0.720 0.280 0.000
D68.0 Von Willebrand's disease
0.000 0.281 0.719
H49 Paralytic strabismus
0.000 0.283 0.717
E10.7 With multiple complications
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
E03.5 Myxoedema coma
0.000 0.283 0.716
E03.4 Atrophy of thyroid (acquired)
0.000 0.283 0.716
E03.3 Postinfectious hypothyroidism
0.000 0.283 0.716
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.283 0.716
E88 Other metabolic disorders
0.000 0.285 0.715
H33.1 Retinoschisis and retinal cysts
0.000 0.291 0.709
L40.3 Pustulosis palmaris et plantaris
0.000 0.291 0.709
L40.2 Acrodermatitis continua
0.000 0.291 0.709
L40.1 Generalised pustular psoriasis
0.000 0.291 0.709
E05.5 Thyroid crisis or storm
0.000 0.291 0.709
E05.4 Thyrotoxicosis factitia
0.000 0.291 0.709
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.291 0.709
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.291 0.709
E27.5 Adrenomedullary hyperfunction
0.000 0.299 0.700
E27.0 Other adrenocortical overactivity
0.000 0.299 0.700
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.302 0.698
E32 Diseases of thymus
0.000 0.302 0.698
E31 Polyglandular dysfunction
0.000 0.302 0.698
E30 Disorders of puberty, not elsewhere classified
0.000 0.302 0.698
H50 Other strabismus
0.000 0.303 0.697
D50.1 Sideropenic dysphagia
0.000 0.304 0.695
H20.9 Iridocyclitis, unspecified
0.000 0.305 0.695
D68.3 Haemorrhagic disorder due to circulating anticoagulants
0.000 0.305 0.695
E14.1 With ketoacidosis
0.000 0.305 0.695
H36.8 Other retinal disorders in diseases classified elsewhere
0.000 0.305 0.694
E10.8 With unspecified complications
0.000 0.306 0.694
H32 Chorioretinal disorders in diseases classified elsewhere
0.000 0.309 0.691
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.314 0.686
E11.1 With ketoacidosis
0.000 0.315 0.685
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.316 0.684
E22 Hyperfunction of pituitary gland
0.000 0.317 0.683
D82 Immunodeficiency associated with other major defects
0.000 0.317 0.683
D81 Combined immunodeficiencies
0.000 0.317 0.683
E07.8 Other specified disorders of thyroid
0.000 0.318 0.682
D52.9 Folate deficiency anaemia, unspecified
0.000 0.319 0.681
D86.3 Sarcoidosis of skin
0.000 0.319 0.681
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes
0.000 0.319 0.681
H02.7 Other degenerative disorders of eyelid and periocular area
0.000 0.320 0.680
E03.1 Congenital hypothyroidism without goitre
0.000 0.321 0.679
H06 Disorders of lachrymal system and orbit in diseases classified elsewhere
0.000 0.322 0.678
D89.2 Hypergammaglobulinaemia, unspecified
0.000 0.322 0.678
E11.3 With ophthalmic complications
0.000 0.324 0.676
H16 Keratitis
0.000 0.324 0.676
H30 Chorioretinal inflammation
0.000 0.329 0.670
Chapter XVI Certain conditions originating in the perinatal period
0.000 0.330 0.670
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.331 0.669
H48 Disorders of optic [2nd] nerve and visual pathways in diseases classified elsewhere
0.000 0.333 0.667
D55-D59 Haemolytic anaemias
0.000 0.333 0.666
G36 Other acute disseminated demyelination
0.000 0.335 0.664
L44 Other papulosquamous disorders
0.000 0.337 0.663
L41 Parapsoriasis
0.000 0.337 0.663
L45 Papulosquamous disorders in diseases classified elsewhere
0.000 0.337 0.663
E05.8 Other thyrotoxicosis
0.000 0.337 0.663
E15 Nondiabetic hypoglycaemic coma
0.000 0.338 0.662
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.339 0.661
E63 Other nutritional deficiencies
0.000 0.339 0.661
E56 Other vitamin deficiencies
0.000 0.339 0.661
E51 Thiamine deficiency
0.000 0.339 0.661
E50 Vitamin A deficiency
0.000 0.339 0.661
E60 Dietary zinc deficiency
0.000 0.339 0.661
E59 Dietary selenium deficiency
0.000 0.339 0.661
E54 Ascorbic acid deficiency
0.000 0.339 0.661
E52 Niacin deficiency [pellagra]
0.000 0.339 0.661
E06.9 Thyroiditis, unspecified
0.000 0.340 0.660
E53.8 Deficiency of other specified B group vitamins
0.000 0.341 0.659
E24 Cushing's syndrome
0.000 0.342 0.658
L40.4 Guttate psoriasis
0.000 0.343 0.657
E14.7 With multiple complications
0.000 0.343 0.657
E14.6 With other specified complications
0.000 0.343 0.657
E14.0 With coma
0.000 0.343 0.657
H02.4 Ptosis of eyelid
0.000 0.343 0.657
L27 Dermatitis due to substances taken internally
0.000 0.345 0.655
E14.8 With unspecified complications
0.000 0.347 0.653
H20.1 Chronic iridocyclitis
0.000 0.348 0.652
D65 Disseminated intravascular coagulation [defibrination syndrome]
0.000 0.348 0.652
D86.0 Sarcoidosis of lung
0.000 0.349 0.651
E14.2 Withrenal complications
0.000 0.351 0.649
C82.7 Other types of follicular non-Hodgkin's lymphoma
0.648 0.352 0.000
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.353 0.647
E85 Amyloidosis
0.000 0.353 0.647
H02.0 Entropion and trichiasis of eyelid
0.000 0.353 0.647
H49.0 Third [oculomotor] nerve palsy
0.000 0.355 0.645
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.356 0.644
C82.4 Follicular lymphoma grade IIIb
0.644 0.356 0.000
E06.5 Other chronic thyroiditis
0.000 0.358 0.642
E06.4 Drug-induced thyroiditis
0.000 0.358 0.642
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.358 0.642
E06.1 Subacute thyroiditis
0.000 0.358 0.642
E06.0 Acute thyroiditis
0.000 0.358 0.642
H19 Disorders of sclera and cornea in diseases classified elsewhere
0.000 0.359 0.641
H47.3 Other disorders of optic disk
0.000 0.364 0.636
H02.6 Xanthelasma of eyelid
0.000 0.365 0.635
D68.5 Primary Thrombophilia
0.000 0.365 0.635
H50.5 Heterophoria
0.000 0.366 0.634
H47.2 Optic atrophy
0.000 0.366 0.634
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.367 0.633
E04.8 Other specified non-toxic goitre
0.000 0.367 0.633
G37 Other demyelinating diseases of central nervous system
0.000 0.368 0.632
E25 Adrenogenital disorders
0.000 0.369 0.630
G20-G26 Extrapyramidal and movement disorders
0.000 0.370 0.630
D89.9 Disorder involving the immune mechanism, unspecified
0.000 0.374 0.626
H16.0 Corneal ulcer
0.000 0.376 0.624
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.377 0.623
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.377 0.623
E16.4 Abnormal secretion of gastrin
0.000 0.377 0.623
E16.3 Increased secretion of glucagon
0.000 0.377 0.623
E55.0 Rickets, active
0.000 0.381 0.618
D51.8 Other vitamin B12 deficiency anaemias
0.000 0.382 0.617
D51.3 Other dietary vitamin B12 deficiency anaemia
0.000 0.382 0.617
D51.2 Transcobalamin II deficiency
0.000 0.382 0.617
D51.1 Vitamin B12 deficiency anaemia due to selective vitamin B12 malabsorption with proteinuria
0.000 0.382 0.617
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.000 0.384 0.616
H05 Disorders of orbit
0.000 0.385 0.615
G90-G99 Other disorders of the nervous system
0.000 0.386 0.614
E78.4 Other hyperlipidaemia
0.000 0.387 0.613
E03.8 Other specified hypothyroidism
0.000 0.387 0.612
E20 Hypoparathyroidism
0.000 0.388 0.612
C82.6 Cutaneous follicle centre lymphoma
0.606 0.394 0.000
C82.5 Diffuse follicle centre lymphoma
0.606 0.394 0.000
D68.8 Other specified coagulation defects
0.000 0.395 0.605
E73 Lactose intolerance
0.000 0.395 0.605
L13 Other bullous disorders
0.000 0.398 0.602
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.398 0.601
H49.1 Fourth [trochlear] nerve palsy
0.000 0.401 0.599
E78.2 Mixed hyperlipidaemia
0.000 0.404 0.596
C82.2 Large cell, follicular
0.595 0.405 0.000
E61 Deficiency of other nutrient elements
0.000 0.407 0.593
E40-E46 Malnutrition
0.000 0.407 0.592
E14.4 With neurological complications
0.000 0.409 0.591
D67 Hereditary factor IX deficiency
0.000 0.409 0.591
G30-G32 Other degenerative diseases of the nervous system
0.000 0.410 0.590
L21 Seborrhoeic dermatitis
0.000 0.411 0.588
E14.5 With peripheral circulatory complications
0.000 0.412 0.588
E58 Dietary calcium deficiency
0.000 0.412 0.588
H00 Hordeolum and chalazion
0.000 0.413 0.587
E11.4 With neurological complications
0.000 0.418 0.582
H11 Other disorders of conjunctiva
0.000 0.418 0.582
H03 Disorders of eyelid in diseases classified elsewhere
0.000 0.422 0.578
E88.2 Lipomatosis, not elsewhere classified
0.000 0.422 0.578
L28 Lichen simplex chronicus and prurigo
0.000 0.423 0.577
E16.1 Other hypoglycaemia
0.000 0.423 0.577
D59 Acquired haemolytic anaemia
0.000 0.423 0.577
D66 Hereditary factor VIII deficiency
0.000 0.424 0.576
L27.0 Generalised skin eruption due to drugs and medicaments
0.000 0.424 0.576
D52.8 Other folate deficiency anaemias
0.000 0.425 0.575
D52.1 Drug-induced folate deficiency anaemia
0.000 0.425 0.575
D52.0 Dietary folate deficiency anaemia
0.000 0.425 0.575
E07.1 Dyshormogenetic goitre
0.000 0.425 0.575
E07.0 Hypersecretion of calcitonin
0.000 0.425 0.575
L11 Other acantholytic disorders
0.000 0.425 0.575
H34 Retinal vascular occlusions
0.000 0.426 0.574
E79 Disorders of purine and pyrimidine metabolism
0.000 0.431 0.569
E77 Disorders of glycoprotein metabolism
0.000 0.431 0.569
E76 Disorders of glycosaminoglycan metabolism
0.000 0.431 0.569
E72 Other disorders of amino-acid metabolism
0.000 0.431 0.569
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.431 0.569
E70 Disorders of aromatic amino-acid metabolism
0.000 0.431 0.569
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.431 0.569
H20.2 Lens-induced iridocyclitis
0.000 0.431 0.569
D83 Common variable immunodeficiency
0.000 0.432 0.568
D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified
0.000 0.432 0.568
D89.3 Immune reconstitution syndrome
0.000 0.432 0.568
D89.0 Polyclonal hypergammaglobulinaemia
0.000 0.432 0.568
E74 Other disorders of carbohydrate metabolism
0.000 0.433 0.567
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system
0.000 0.434 0.566
D51.0 Vitamin B12 deficiency anaemia due to intrinsic factor deficiency
0.000 0.434 0.566
E28 Ovarian dysfunction
0.000 0.435 0.565
E34 Other endocrine disorders
0.000 0.442 0.558
E53.9 Vitamin B deficiency, unspecified
0.000 0.442 0.558
D68.2 Hereditary deficiency of other clotting factors
0.000 0.443 0.557
H47.7 Disorder of visual pathways, unspecified
0.000 0.443 0.556
H47.6 Disorders of visual cortex
0.000 0.443 0.556
H47.5 Disorders of other visual pathways
0.000 0.443 0.556
H47.4 Disorders of optic chiasm
0.000 0.443 0.556
L23 Allergic contact dermatitis
0.000 0.446 0.554
E53.1 Pyridoxine deficiency
0.000 0.448 0.552
E53.0 Riboflavin deficiency
0.000 0.448 0.552
E29 Testicular dysfunction
0.000 0.450 0.550
D53.9 Nutritional anaemia, unspecified
0.000 0.450 0.550
H51 Other disorders of binocular movement
0.000 0.451 0.549
E78.8 Other disorders of lipoprotein metabolism
0.000 0.451 0.549
Chapter XXII Codes for special purposes
0.000 0.453 0.547
L25 Unspecified contact dermatitis
0.000 0.453 0.547
D68.4 Acquired coagulation factor deficiency
0.000 0.455 0.545
H15 Disorders of sclera
0.000 0.458 0.542
H10 Conjunctivitis
0.000 0.458 0.542
D84 Other immunodeficiencies
0.001 0.459 0.541
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.460 0.540
L12 Pemphigoid
0.000 0.460 0.540
H47.1 Papilloedema, unspecified
0.000 0.460 0.539
H50.1 Divergent concomitant strabismus
0.000 0.461 0.539
L10 Pemphigus
0.000 0.463 0.537
L14 Bullous disorders in diseases classified elsewhere
0.000 0.463 0.537
H50.9 Strabismus, unspecified
0.000 0.463 0.537
E13 Other specified diabetes mellitus
0.000 0.464 0.535
H49.9 Paralytic strabismus, unspecified
0.000 0.466 0.534
E84 Cystic fibrosis
0.000 0.467 0.533
H01 Other inflammation of eyelid
0.000 0.468 0.532
E07.9 Disorder of thyroid, unspecified
0.000 0.469 0.531
E65-E68 Obesity and other hyperalimentation
0.000 0.469 0.531
L24 Irritant contact dermatitis
0.000 0.470 0.530
L26 Exfoliative dermatitis
0.000 0.470 0.530
L22 Diaper [napkin] dermatitis
0.000 0.470 0.530
E85.9 Amyloidosis, unspecified
0.000 0.471 0.529
H47.0 Disorders of optic nerve, not elsewhere classified
0.000 0.472 0.528
E88.8 Other specified metabolic disorders
0.000 0.472 0.528
E11.8 With unspecified complications
0.000 0.473 0.527
E22.0 Acromegaly and pituitary gigantism
0.000 0.474 0.526
H22 Disorders of iris and ciliary body in diseases classified elsewhere
0.000 0.474 0.526
E11.7 With multiple complications
0.000 0.475 0.525
L42 Pityriasis rosea
0.001 0.476 0.523
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.000 0.477 0.523
G25 Other extrapyramidal and movement disorders
0.000 0.477 0.523
G91 Hydrocephalus
0.000 0.477 0.523
D53.8 Other specified nutritional anaemias
0.000 0.480 0.520
D53.2 Scorbutic anaemia
0.000 0.480 0.520
D53.1 Other megaloblastic anaemias, not elsewhere classified
0.000 0.480 0.520
D53.0 Protein deficiency anaemia
0.000 0.480 0.520
H05.0 Acute inflammation of orbit
0.000 0.481 0.519
E11.2 With renal complications
0.000 0.483 0.517
H49.8 Other paralytic strabismus
0.000 0.486 0.514
H49.4 Progressive external ophthalmoplegia
0.000 0.486 0.514
H49.3 Total (external) ophthalmoplegia
0.000 0.486 0.514
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.486 0.514
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.486 0.514
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.486 0.514
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.486 0.514
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.486 0.514
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.486 0.514
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.486 0.514
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.486 0.514
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
H50.4 Other and unspecified heterotropia
0.000 0.486 0.514
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.487 0.513
E88.3 Tumour lysis syndrome
0.000 0.490 0.510
E85.4 Organ-limited amyloidosis
0.000 0.491 0.509
H17 Corneal scars and opacities
0.000 0.491 0.509
H50.8 Other specified strabismus
0.000 0.495 0.505
H13 Disorders of conjunctiva in diseases classified elsewhere
0.000 0.497 0.503
G98 Other disorders of nervous system, not elsewhere classified
0.000 0.499 0.501
D59.1 Other autoimmune haemolytic anaemias
0.000 0.499 0.501
D68.1 Hereditary factor XI deficiency
0.000 0.499 0.501
E30.9 Disorder of puberty, unspecified
0.000 0.499 0.500
E30.8 Other disorders of puberty
0.000 0.499 0.500
E30.1 Precocious puberty
0.000 0.499 0.500
E30.0 Delayed puberty
0.000 0.499 0.500
E31.9 Polyglandular dysfunction, unspecified
0.000 0.499 0.500
E31.8 Other polyglandular dysfunction
0.000 0.499 0.500
E31.1 Polyglandular hyperfunction
0.000 0.499 0.500
E31.0 Autoimmune polyglandular failure
0.000 0.499 0.500
E32.9 Disease of thymus, unspecified
0.000 0.499 0.500
E32.8 Other diseases of thymus
0.000 0.499 0.500
E32.1 Abscess of thymus
0.000 0.499 0.500
E32.0 Persistent hyperplasia of thymus
0.000 0.499 0.500
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.499 0.500
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.499 0.500
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.499 0.500
E24.0 Pituitary-dependent Cushing's disease
0.000 0.499 0.501
L27.1 Localised skin eruption due to drugs and medicaments
0.000 0.499 0.500
L20 Atopic dermatitis
0.000 0.500 0.500
H50.6 Mechanical strabismus
0.000 0.500 0.500
H50.3 Intermittent heterotropia
0.000 0.500 0.500
G63 Polyneuropathy in diseases classified elsewhere
0.000 0.502 0.498
H00.0 Hordeolum and other deep inflammation of eyelid
0.000 0.502 0.498
L13.0 Dermatitis herpetiformis
0.000 0.502 0.498
G93 Other disorders of brain
0.000 0.504 0.496
H32.8 Other chorioretinal disorders in diseases classified elsewhere
0.000 0.504 0.496
H32.0 Chorioretinal inflammation in infectious and parasitic diseases classified elsewhere
0.000 0.504 0.496
H19.3 Keratitis and keratoconjunctivitis in other diseases classified elsewhere
0.000 0.504 0.496
L50-L54 Urticaria and erythema
0.000 0.504 0.496
H53-H54 Visual disturbances and blindness
0.000 0.504 0.496
H11.9 Disorder of conjunctiva, unspecified
0.000 0.504 0.496
E26 Hyperaldosteronism
0.001 0.506 0.493
G31 Other degenerative diseases of nervous system, not elsewhere classified
0.000 0.507 0.493
D68.6 Other Thrombophilia
0.000 0.507 0.493
E78.6 Lipoprotein deficiency
0.000 0.510 0.490
E78.3 Hyperchylomicronaemia
0.000 0.510 0.490
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.510 0.490
E22.8 Other hyperfunction of pituitary gland
0.000 0.510 0.490
D81.9 Combined immunodeficiency, unspecified
0.000 0.510 0.489
D81.8 Other combined immunodeficiencies
0.000 0.510 0.489
D81.7 Major histocompatibility complex class II deficiency
0.000 0.510 0.489
D81.6 Major histocompatibility complex class I deficiency
0.000 0.510 0.489
D81.5 Purine nucleoside phosphorylase [PNP] deficiency
0.000 0.510 0.489
D81.4 Nezelof's syndrome
0.000 0.510 0.489
D81.3 Adenosine deaminase [ADA] deficiency
0.000 0.510 0.489
D81.2 Severe combined immunodeficiency [SCID] with low or normal B-cell numbers
0.000 0.510 0.489
D81.1 Severe combined immunodeficiency [SCID] with low T- and B-cell numbers
0.000 0.510 0.489
D81.0 Severe combined immunodeficiency [SCID] with reticular dysgenesis
0.000 0.510 0.489
D82.9 Immunodeficiency associated with major defect, unspecified
0.000 0.510 0.489
D82.8 Immunodeficiency associated with other specified major defects
0.000 0.510 0.489
D82.4 Hyperimmunoglobulin E [IgE] syndrome
0.000 0.510 0.489
D82.3 Immunodeficiency following hereditary defective response to Epstein-Barr virus
0.000 0.510 0.489
D82.2 Immunodeficiency with short-limbed stature
0.000 0.510 0.489
D82.1 Di George's syndrome
0.000 0.510 0.489
D82.0 Wiskott-Aldrich syndrome
0.000 0.510 0.489
H50.0 Convergent concomitant strabismus
0.000 0.513 0.487
H18 Other disorders of cornea
0.000 0.513 0.487
H06.3 Other disorders of orbit in diseases classified elsewhere
0.000 0.513 0.486
H06.1 Parasitic infestation of orbit in diseases classified elsewhere
0.000 0.513 0.486
H06.0 Disorders of lachrymal system in diseases classified elsewhere
0.000 0.513 0.486
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.514 0.486
H06.2 Dysthyroid exophthalmos
0.000 0.514 0.486
L27.2 Dermatitis due to ingested food
0.000 0.514 0.485
H16.8 Other keratitis
0.000 0.515 0.485
H16.4 Corneal neovascularisation
0.000 0.515 0.485
H16.3 Interstitial and deep keratitis
0.000 0.515 0.485
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.516 0.484
D89.1 Cryoglobulinaemia
0.000 0.516 0.484
E23 Hypofunction and other disorders of pituitary gland
0.000 0.517 0.483
H30.8 Other chorioretinal inflammations
0.000 0.519 0.481
H30.2 Posterior cyclitis
0.000 0.519 0.481
H30.1 Disseminated chorioretinal inflammation
0.000 0.519 0.481
H30.0 Focal chorioretinal inflammation
0.000 0.519 0.481
P90-P96 Other disorders originating in the perinatal period
0.000 0.519 0.480
P80-P83 Conditions involving the integument and temperature regulation of fetus and newborn
0.000 0.519 0.480
P75-P78 Digestive system disorders of fetus and newborn
0.000 0.519 0.480
P70-P74 Transitory endocrine and metabolic disorders specific to fetus and newborn
0.000 0.519 0.480
P50-P61 Haemorrhagic and haematological disorders of fetus and newborn
0.000 0.519 0.480
P35-P39 Infections specific to the perinatal period
0.000 0.519 0.480
P20-P29 Respiratory and cardiovascular disorders specific to the perinatal period
0.000 0.519 0.480
P10-P15 Birth trauma
0.000 0.519 0.480
P05-P08 Disorders related to length of gestation and fetal growth
0.000 0.519 0.480
P00-P04 Fetus and newborn affected by maternal factors and by complications of pregnancy, labour and delivery
0.000 0.519 0.480
L21.9 Seborrhoeic dermatitis, unspecified
0.000 0.519 0.480
D70-D77 Other diseases of blood and blood-forming organs
0.000 0.521 0.479
H48.8 Other disorders of optic nerve and visual pathways in diseases classified elsewhere
0.000 0.521 0.478
H48.1 Retrobulbar neuritis in diseases classified elsewhere
0.000 0.521 0.478
H48.0 Optic atrophy in diseases classified elsewhere
0.000 0.521 0.478
D55 Anaemia due to enzyme disorders
0.000 0.522 0.478
G36.9 Acute disseminated demyelination, unspecified
0.000 0.523 0.476
G36.8 Other specified acute disseminated demyelination
0.000 0.523 0.476
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.000 0.523 0.476
G36.0 Neuromyelitis optica [Devic]
0.000 0.523 0.476
L41.9 Parapsoriasis, unspecified
0.000 0.524 0.475
L41.8 Other parapsoriasis
0.000 0.524 0.475
L41.5 Retiform parapsoriasis
0.000 0.524 0.475
L41.4 Large plaque parapsoriasis
0.000 0.524 0.475
L41.3 Small plaque parapsoriasis
0.000 0.524 0.475
L41.2 Lymphomatoid papulosis
0.000 0.524 0.475
L41.1 Pityriasis lichenoides chronica
0.000 0.524 0.475
L41.0 Pityriasis lichenoides et varioliformis acuta
0.000 0.524 0.475
L44.9 Papulosquamous disorder, unspecified
0.000 0.524 0.475
L44.8 Other specified papulosquamous disorders
0.000 0.524 0.475
L44.4 Infantile papular acrodermatitis [Giannotti-Crosti]
0.000 0.524 0.475
L44.3 Lichen ruber moniliformis
0.000 0.524 0.475
L44.2 Lichen striatus
0.000 0.524 0.475
L44.1 Lichen nitidus
0.000 0.524 0.475
L44.0 Pityriasis rubra pilaris
0.000 0.524 0.475
G94 Other disorders of brain in diseases classified elsewhere
0.000 0.525 0.475
E50.9 Vitamin A deficiency, unspecified
0.000 0.526 0.474
E50.8 Other manifestations of vitamin A deficiency
0.000 0.526 0.474
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.526 0.474
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.526 0.474
E50.5 Vitamin A deficiency with night blindness
0.000 0.526 0.474
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.526 0.474
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.526 0.474
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.526 0.474
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.526 0.474
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.526 0.474
E51.9 Thiamine deficiency, unspecified
0.000 0.526 0.474
E51.8 Other manifestations of thiamine deficiency
0.000 0.526 0.474
E51.2 Wernicke's encephalopathy
0.000 0.526 0.474
E51.1 Beriberi
0.000 0.526 0.474
E56.9 Vitamin deficiency, unspecified
0.000 0.526 0.474
E56.8 Deficiency of other vitamins
0.000 0.526 0.474
E56.1 Deficiency of vitamin K
0.000 0.526 0.474
E56.0 Deficiency of vitamin E
0.000 0.526 0.474
E63.9 Nutritional deficiency, unspecified
0.000 0.526 0.474
E63.8 Other specified nutritional deficiencies
0.000 0.526 0.474
E63.1 Imbalance of constituents of food intake
0.000 0.526 0.474
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.526 0.474
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.526 0.474
E64.8 Sequelae of other nutritional deficiencies
0.000 0.526 0.474
E64.3 Sequelae of rickets
0.000 0.526 0.474
E64.2 Sequelae of vitamin C deficiency
0.000 0.526 0.474
E64.1 Sequelae of vitamin A deficiency
0.000 0.526 0.474
E64.0 Sequelae of protein-energy malnutrition
0.000 0.526 0.474
H19.1 Herpesviral keratitis and keratoconjunctivitis
0.000 0.527 0.473
G25.0 Essential tremor
0.000 0.528 0.472
E24.8 Other Cushing's syndrome
0.000 0.528 0.472

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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