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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs1029388
log Bayes Factor = 19.1784
Chromosome 12   position 111,926,901  (GRCh37) Explore rs1029388 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
I25 Chronic ischaemic heart disease
0.000 0.000 1.000
I21 Acute myocardial infarction
0.000 0.000 1.000
I20-I25 Ischaemic heart diseases
0.000 0.000 1.000
I10 Essential (primary) hypertension
0.000 0.000 1.000
I21.1 Acute transmural myocardial infarction of inferior wall
0.000 0.000 1.000
I25.8 Other forms of chronic ischaemic heart disease
0.000 0.000 1.000
I25.1 Atherosclerotic heart disease
0.000 0.001 0.999
E03 Other hypothyroidism
0.000 0.002 0.998
E00-E07 Disorders of thyroid gland
0.000 0.003 0.997
I21.0 Acute transmural myocardial infarction of anterior wall
0.000 0.006 0.994
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.006 0.994
E20-E35 Disorders of other endocrine glands
0.000 0.006 0.994
E27 Other disorders of adrenal gland
0.000 0.010 0.990
I10-I15 Hypertensive diseases
0.000 0.012 0.988
Chapter IX Diseases of the circulatory system
0.000 0.014 0.986
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.025 0.975
E27.1 Primary adrenocortical insufficiency
0.000 0.032 0.968
E05.9 Thyrotoxicosis, unspecified
0.000 0.034 0.966
E10-E14 Diabetes mellitus
0.000 0.045 0.955
I22 Subsequent myocardial infarction
0.000 0.047 0.953
E10 Insulin-dependent diabetes mellitus
0.000 0.048 0.952
Z95.5 Presence of coronary angioplasty implant and graft
0.000 0.054 0.946
Z95 Presence of cardiac and vascular implants and grafts
0.000 0.055 0.945
Z95.1 Presence of aortocoronary bypass graft
0.000 0.056 0.944
I95-I99 Other and unspecified disorders of the circulatory system
0.000 0.060 0.940
I25.5 Ischaemic cardiomyopathy
0.000 0.065 0.935
I22.9 Subsequent myocardial infarction of unspecified site
0.000 0.078 0.922
E10.3 With ophthalmic complications
0.000 0.085 0.915
E23 Hypofunction and other disorders of pituitary gland
0.000 0.087 0.913
I30-I52 Other forms of heart disease
0.000 0.087 0.913
I49 Other cardiac arrhythmias
0.000 0.090 0.910
E10.9 Without complications
0.000 0.090 0.910
I49.9 Cardiac arrhythmia, unspecified
0.000 0.094 0.906
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.098 0.902
Z95.3 Presence of xenogenic heart valve
0.000 0.103 0.897
I35 Nonrheumatic aortic valve disorders
0.000 0.104 0.896
I97 Postprocedural disorders of circulatory system, not elsewhere classified
0.000 0.108 0.892
I49.3 Ventricular premature depolarisation
0.000 0.110 0.890
I35.0 Aortic (valve) stenosis
0.000 0.123 0.877
I21.9 Acute myocardial infarction, unspecified
0.000 0.127 0.873
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.130 0.870
E50-E64 Other nutritional deficiencies
0.000 0.134 0.866
I47 Paroxysmal tachycardia
0.000 0.140 0.860
I35.2 Aortic (valve) stenosis with insufficiency
0.000 0.142 0.858
I99 Other and unspecified disorders of circulatory system
0.000 0.150 0.850
E28 Ovarian dysfunction
0.000 0.158 0.842
E27.8 Other specified disorders of adrenal gland
0.000 0.158 0.842
I47.2 Ventricular tachycardia
0.000 0.159 0.841
E23.2 Diabetes insipidus
0.000 0.167 0.833
I42 Cardiomyopathy
0.000 0.171 0.829
E21.0 Primary hyperparathyroidism
0.000 0.178 0.822
I97.1 Other functional disturbances following cardiac surgery
0.000 0.187 0.813
I21.2 Acute transmural myocardial infarction of other sites
0.000 0.188 0.812
I25.2 Old myocardial infarction
0.000 0.195 0.805
E22 Hyperfunction of pituitary gland
0.000 0.197 0.803
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.203 0.797
E34 Other endocrine disorders
0.000 0.204 0.796
E27.2 Addisonian crisis
0.000 0.208 0.792
I23 Certain current complications following acute myocardial infarction
0.000 0.211 0.789
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.217 0.783
E10.5 With peripheral circulatory complications
0.000 0.219 0.781
E10.4 With neurological complications
0.000 0.220 0.780
E10.0 With coma
0.000 0.229 0.771
E06 Thyroiditis
0.000 0.229 0.771
I49.0 Ventricular fibrillation and flutter
0.000 0.236 0.764
E03.8 Other specified hypothyroidism
0.000 0.246 0.753
Z95.2 Presence of prosthetic heart valve
0.000 0.248 0.752
I22.1 Subsequent myocardial infarction of inferior wall
0.000 0.248 0.752
I47.9 Paroxysmal tachycardia, unspecified
0.000 0.255 0.745
I25.4 Coronary artery aneurysm
0.000 0.256 0.744
I97.2 Postmastectomy lymphoedema syndrome
0.000 0.260 0.740
I42.9 Cardiomyopathy, unspecified
0.000 0.265 0.735
E61 Deficiency of other nutrient elements
0.000 0.265 0.735
I98 Other disorders of circulatory system in diseases classified elsewhere
0.000 0.269 0.731
Z95.4 Presence of other heart-valve replacement
0.000 0.270 0.730
E23.6 Other disorders of pituitary gland
0.000 0.274 0.726
I21.3 Acute transmural myocardial infarction of unspecified site
0.000 0.276 0.724
I25.3 Aneurysm of heart
0.000 0.277 0.723
I42.1 Obstructive hypertrophic cardiomyopathy
0.000 0.279 0.721
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.279 0.721
I20 Angina pectoris
0.000 0.280 0.720
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.281 0.719
I21.X Presumed acute myicardial infaction (unconfirmed)
0.000 0.283 0.717
I25.6 Silent myocardial ischaemia
0.000 0.283 0.717
E53 Deficiency of other B group vitamins
0.000 0.283 0.716
E03.5 Myxoedema coma
0.000 0.285 0.715
E03.4 Atrophy of thyroid (acquired)
0.000 0.285 0.715
E03.3 Postinfectious hypothyroidism
0.000 0.285 0.715
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.285 0.715
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.285 0.715
E00 Congenital iodine-deficiency syndrome
0.000 0.285 0.715
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.288 0.712
E32 Diseases of thymus
0.000 0.288 0.712
E31 Polyglandular dysfunction
0.000 0.288 0.712
E30 Disorders of puberty, not elsewhere classified
0.000 0.288 0.712
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.289 0.711
E27.5 Adrenomedullary hyperfunction
0.000 0.290 0.710
E27.0 Other adrenocortical overactivity
0.000 0.290 0.710
I97.8 Other postprocedural disorders of circulatory system, not elsewhere classified
0.000 0.290 0.710
I13 Hypertensive heart and renal disease
0.000 0.292 0.708
I00-I02 Acute rheumatic fever
0.000 0.293 0.707
I20.8 Other forms of angina pectoris
0.000 0.294 0.706
E10.2 With renal complications
0.000 0.295 0.705
E10.8 With unspecified complications
0.000 0.299 0.701
E05.5 Thyroid crisis or storm
0.000 0.301 0.699
E05.4 Thyrotoxicosis factitia
0.000 0.301 0.699
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.301 0.699
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.301 0.699
E28.2 Polycystic ovarian syndrome
0.000 0.307 0.693
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.309 0.691
E23.7 Disorder of pituitary gland, unspecified
0.000 0.310 0.690
E12 Malnutrition-related diabetes mellitus
0.000 0.315 0.685
E27.9 Disorder of adrenal gland, unspecified
0.000 0.316 0.684
E10.6 With other specified complications
0.000 0.317 0.683
E20 Hypoparathyroidism
0.000 0.325 0.675
E28.3 Primary ovarian failure
0.000 0.332 0.668
I22.8 Subsequent myocardial infarction of other sites
0.000 0.332 0.668
I50 Heart failure
0.000 0.332 0.668
I42.0 Dilated cardiomyopathy
0.000 0.336 0.664
Z95.8 Presence of other cardiac and vascular implants and grafts
0.000 0.342 0.658
E06.9 Thyroiditis, unspecified
0.000 0.342 0.658
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.345 0.655
E23.1 Drug-induced hypopituitarism
0.000 0.345 0.655
I52 Other heart disorders in diseases classified elsewhere
0.000 0.345 0.654
I48 Atrial fibrillation and flutter
0.000 0.345 0.654
I43 Cardiomyopathy in diseases classified elsewhere
0.000 0.345 0.654
I41 Myocarditis in diseases classified elsewhere
0.000 0.345 0.654
I39 Endocarditis and heart valve disorders in diseases classified elsewhere
0.000 0.345 0.654
I32 Pericarditis in diseases classified elsewhere
0.000 0.345 0.654
E25 Adrenogenital disorders
0.000 0.347 0.653
I49.2 Junctional premature depolarisation
0.000 0.347 0.653
I37 Pulmonary valve disorders
0.000 0.349 0.651
E10.1 With ketoacidosis
0.000 0.350 0.650
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.352 0.648
Z95.0 Presence of cardiac pacemaker
0.000 0.352 0.648
E21.4 Other specified disorders of parathyroid gland
0.000 0.353 0.647
E21.2 Other hyperparathyroidism
0.000 0.353 0.647
I97.9 Postprocedural disorder of circulatory system, unspecified
0.000 0.361 0.639
I97.0 Postcardiotomy syndrome
0.000 0.361 0.639
E34.9 Endocrine disorder, unspecified
0.000 0.361 0.639
I23.8 Other current complications following acute myocardial infarction
0.000 0.362 0.638
E03.1 Congenital hypothyroidism without goitre
0.000 0.369 0.631
I25.0 Atherosclerotic cardiovascular disease, so described
0.000 0.369 0.631
I42.2 Other hypertrophic cardiomyopathy
0.000 0.370 0.630
I25.9 Chronic ischaemic heart disease, unspecified
0.000 0.374 0.626
E26 Hyperaldosteronism
0.000 0.375 0.625
E05.8 Other thyrotoxicosis
0.000 0.376 0.624
I24 Other acute ischaemic heart diseases
0.000 0.377 0.623
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.379 0.621
E63 Other nutritional deficiencies
0.000 0.379 0.621
E56 Other vitamin deficiencies
0.000 0.379 0.621
E51 Thiamine deficiency
0.000 0.379 0.621
E50 Vitamin A deficiency
0.000 0.379 0.621
E60 Dietary zinc deficiency
0.000 0.379 0.621
E59 Dietary selenium deficiency
0.000 0.379 0.621
E58 Dietary calcium deficiency
0.000 0.379 0.621
E54 Ascorbic acid deficiency
0.000 0.379 0.621
E52 Niacin deficiency [pellagra]
0.000 0.379 0.621
I33 Acute and subacute endocarditis
0.000 0.379 0.620
E23.0 Hypopituitarism
0.000 0.386 0.614
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.387 0.612
E61.1 Iron deficiency
0.000 0.390 0.610
E34.0 Carcinoid syndrome
0.000 0.394 0.606
E21.3 Hyperparathyroidism, unspecified
0.000 0.395 0.605
E28.9 Ovarian dysfunction, unspecified
0.000 0.396 0.604
E28.8 Other ovarian dysfunction
0.000 0.396 0.604
E28.1 Androgen excess
0.000 0.396 0.604
E28.0 Oestrogen excess
0.000 0.396 0.604
E07 Other disorders of thyroid
0.000 0.400 0.600
I21.4 Acute subendocardial myocardial infarction
0.000 0.401 0.599
I42.5 Other restrictive cardiomyopathy
0.000 0.405 0.594
I42.4 Endocardial fibroelastosis
0.000 0.405 0.594
I42.3 Endomyocardial (eosinophilic) disease
0.000 0.405 0.594
I49.4 Other and unspecified premature depolarisation
0.000 0.409 0.591
E14 Unspecified diabetes mellitus
0.000 0.410 0.590
I42.6 Alcoholic cardiomyopathy
0.000 0.415 0.585
E55 Vitamin D deficiency
0.000 0.415 0.585
I11 Hypertensive heart disease
0.000 0.419 0.581
E61.2 Magnesium deficiency
0.000 0.423 0.577
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.424 0.576
E22.8 Other hyperfunction of pituitary gland
0.000 0.424 0.576
I36 Nonrheumatic tricuspid valve disorders
0.000 0.425 0.575
E53.9 Vitamin B deficiency, unspecified
0.000 0.425 0.575
E34.5 Androgen resistance syndrome
0.000 0.429 0.571
E34.4 Constitutional tall stature
0.000 0.429 0.571
E34.3 Short stature, not elsewhere classified
0.000 0.429 0.571
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.429 0.571
E34.1 Other hypersecretion of intestinal hormones
0.000 0.429 0.571
I22.0 Subsequent myocardial infarction of anterior wall
0.000 0.429 0.571
E22.1 Hyperprolactinaemia
0.000 0.432 0.568
I23.6 Thrombosis of atrium, auricular appendage and ventricle as current complications following acute myocardial infarction
0.000 0.434 0.566
I23.5 Rupture of papillary muscle as current complication following acute myocardial infarction
0.000 0.434 0.566
I23.4 Rupture of chordae tendineae as current complication following acute myocardial infarction
0.000 0.434 0.566
I23.3 Rupture of cardiac wall without haemopericardium as current complication following acute myocardial infarction
0.000 0.434 0.566
I23.2 Ventricular septal defect as current complication following acute myocardial infarction
0.000 0.434 0.566
I23.1 Atrial septal defect as current complication following acute myocardial infarction
0.000 0.434 0.566
I23.0 Haemopericardium as current complication following acute myocardial infarction
0.000 0.434 0.566
E53.8 Deficiency of other specified B group vitamins
0.000 0.437 0.563
I47.0 Reentry ventricular arrhythmia
0.000 0.440 0.560
I35.8 Other aortic valve disorders
0.000 0.440 0.560
E40-E46 Malnutrition
0.000 0.441 0.559
E34.8 Other specified endocrine disorders
0.000 0.443 0.557
I98.3 Oesophageal varices with bleeding in diseases classified elsewhere
0.000 0.445 0.555
I98.2 Oesophageal varices in diseases classified elsewhere
0.000 0.445 0.554
E06.4 Drug-induced thyroiditis
0.000 0.447 0.552
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.447 0.552
E06.1 Subacute thyroiditis
0.000 0.447 0.552
E06.0 Acute thyroiditis
0.000 0.447 0.552
I15 Secondary hypertension
0.000 0.452 0.547
E29 Testicular dysfunction
0.000 0.455 0.545
I24.8 Other forms of acute ischaemic heart disease
0.000 0.459 0.541
I35.9 Aortic valve disorder, unspecified
0.000 0.468 0.532
Z95.9 Presence of cardiac and vascular implant and graft, unspecified
0.000 0.469 0.531
E06.3 Autoimmune thyroiditis
0.000 0.472 0.528
E61.9 Deficiency of nutrient element, unspecified
0.000 0.473 0.527
E61.8 Deficiency of other specified nutrient elements
0.000 0.473 0.527
E61.7 Deficiency of multiple nutrient elements
0.000 0.473 0.527
E61.6 Vanadium deficiency
0.000 0.473 0.527
E61.5 Molybdenum deficiency
0.000 0.473 0.527
E61.4 Chromium deficiency
0.000 0.473 0.527
E61.3 Manganese deficiency
0.000 0.473 0.527
E61.0 Copper deficiency
0.000 0.473 0.527
I98.8 Other specified disorders of circulatory system in diseases classified elsewhere
0.000 0.476 0.524
I98.1 Cardiovascular disorders in other infectious and parasitic diseases classified elsewhere
0.000 0.476 0.524
I98.0 Cardiovascular syphilis
0.000 0.476 0.524
I50.9 Heart failure, unspecified
0.000 0.479 0.521
E10.7 With multiple complications
0.000 0.482 0.518
I50.1 Left ventricular failure
0.000 0.484 0.516
E53.1 Pyridoxine deficiency
0.000 0.486 0.514
E53.0 Riboflavin deficiency
0.000 0.486 0.514
I40 Acute myocarditis
0.000 0.487 0.513
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.487 0.512
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.487 0.512
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.487 0.512
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.487 0.512
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.487 0.512
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.487 0.512
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.487 0.512
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.487 0.512
E30.9 Disorder of puberty, unspecified
0.000 0.489 0.511
E30.8 Other disorders of puberty
0.000 0.489 0.511
E30.1 Precocious puberty
0.000 0.489 0.511
E30.0 Delayed puberty
0.000 0.489 0.511
E31.9 Polyglandular dysfunction, unspecified
0.000 0.489 0.511
E31.8 Other polyglandular dysfunction
0.000 0.489 0.511
E31.1 Polyglandular hyperfunction
0.000 0.489 0.511
E31.0 Autoimmune polyglandular failure
0.000 0.489 0.511
E32.9 Disease of thymus, unspecified
0.000 0.489 0.511
E32.8 Other diseases of thymus
0.000 0.489 0.511
E32.1 Abscess of thymus
0.000 0.489 0.511
E32.0 Persistent hyperplasia of thymus
0.000 0.489 0.511
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.489 0.511
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.489 0.511
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.489 0.511
I13.9 Hypertensive heart and renal disease, unspecified
0.000 0.492 0.508
I13.2 Hypertensive heart and renal disease with both (congestive) heart failure and renal failure
0.000 0.492 0.508
I13.1 Hypertensive heart and renal disease with renal failure
0.000 0.492 0.508
I13.0 Hypertensive heart and renal disease with (congestive) heart failure
0.000 0.492 0.508
I02 Rheumatic chorea
0.000 0.493 0.507
I01 Rheumatic fever with heart involvement
0.000 0.493 0.507
I00 Rheumatic fever without mention of heart involvement
0.000 0.493 0.507
E15 Nondiabetic hypoglycaemic coma
0.000 0.504 0.496
I49.5 Sick sinus syndrome
0.000 0.506 0.494
E12.9 Without complications
0.000 0.509 0.491
E12.8 With unspecified complications
0.000 0.509 0.491
E12.7 With multiple complications
0.000 0.509 0.491
E12.6 With other specified complications
0.000 0.509 0.491
E12.5 With peripheral circulatory complications
0.000 0.509 0.491
E12.4 With neurological complications
0.000 0.509 0.491
E12.3 With ophthalmic complications
0.000 0.509 0.491
E12.2 With renal complications
0.000 0.509 0.491
E12.1 With ketoacidosis
0.000 0.509 0.491
E12.0 With coma
0.000 0.509 0.491
I42.8 Other cardiomyopathies
0.000 0.512 0.488
E06.5 Other chronic thyroiditis
0.000 0.513 0.487
E24 Cushing's syndrome
0.000 0.515 0.484
E20.8 Other hypoparathyroidism
0.000 0.516 0.484
E20.1 Pseudohypoparathyroidism
0.000 0.516 0.484
E20.0 Idiopathic hypoparathyroidism
0.000 0.516 0.484
E13 Other specified diabetes mellitus
0.000 0.523 0.476
E16 Other disorders of pancreatic internal secretion
0.000 0.525 0.474
I32.8 Pericarditis in other diseases classified elsewhere
0.000 0.531 0.469
I32.1 Pericarditis in other infectious and parasitic diseases classified elsewhere
0.000 0.531 0.469
I32.0 Pericarditis in bacterial diseases classified elsewhere
0.000 0.531 0.469
I39.8 Endocarditis, valve unspecified, in diseases classified elsewhere
0.000 0.531 0.469
I39.4 Multiple valve disorders in diseases classified elsewhere
0.000 0.531 0.469
I39.3 Pulmonary valve disorders in diseases classified elsewhere
0.000 0.531 0.469
I39.2 Tricuspid valve disorders in diseases classified elsewhere
0.000 0.531 0.469
I39.1 Aortic valve disorders in diseases classified elsewhere
0.000 0.531 0.469
I39.0 Mitral valve disorders in diseases classified elsewhere
0.000 0.531 0.469
I41.8 Myocarditis in other diseases classified elsewhere
0.000 0.531 0.469
I41.2 Myocarditis in other infectious and parasitic diseases classified elsewhere
0.000 0.531 0.469
I41.1 Myocarditis in viral diseases classified elsewhere
0.000 0.531 0.469
I41.0 Myocarditis in bacterial diseases classified elsewhere
0.000 0.531 0.469
I43.8 Cardiomyopathy in other diseases classified elsewhere
0.000 0.531 0.469
I43.2 Cardiomyopathy in nutritional diseases
0.000 0.531 0.469
I43.1 Cardiomyopathy in metabolic diseases
0.000 0.531 0.469
I43.0 Cardiomyopathy in infectious and parasitic diseases classified elsewhere
0.000 0.531 0.469
I48.9 Atrial fibrillation and atrial flutter, unspecified
0.000 0.531 0.469
I48.4 Atypical atrial flutter
0.000 0.531 0.469
I48.3 Typical atrial flutter
0.000 0.531 0.469
I48.2 Chronic atrial fibrillation
0.000 0.531 0.469
I48.1 Persistent atrial fibrillation
0.000 0.531 0.469
I48.0 Paroxysmal atrial fibrillation
0.000 0.531 0.469
I52.8 Other heart disorders in other diseases classified elsewhere
0.000 0.531 0.469
I52.1 Other heart disorders in other infectious and parasitic diseases classified elsewhere
0.000 0.531 0.469
I52.0 Other heart disorders in bacterial diseases classified elsewhere
0.000 0.531 0.469
E25.9 Adrenogenital disorder, unspecified
0.000 0.532 0.468
E25.8 Other adrenogenital disorders
0.000 0.532 0.468
I37.9 Pulmonary valve disorder, unspecified
0.000 0.533 0.467
I37.8 Other pulmonary valve disorders
0.000 0.533 0.467
I37.2 Pulmonary valve stenosis with insufficiency
0.000 0.533 0.467
I37.0 Pulmonary valve stenosis
0.000 0.533 0.467
E14.3 With ophthalmic complications
0.000 0.533 0.467
I42.7 Cardiomyopathy due to drugs and other external agents
0.000 0.534 0.465
E14.4 With neurological complications
0.000 0.536 0.464
I37.1 Pulmonary valve insufficiency
0.000 0.537 0.463
I24.1 Dressler's syndrome
0.000 0.537 0.463
E26.8 Other hyperaldosteronism
0.000 0.551 0.448
E26.1 Secondary hyperaldosteronism
0.000 0.551 0.448
E20.9 Hypoparathyroidism, unspecified
0.000 0.553 0.447
E22.0 Acromegaly and pituitary gigantism
0.000 0.553 0.447
E14.6 With other specified complications
0.000 0.553 0.447
E50.9 Vitamin A deficiency, unspecified
0.000 0.555 0.445
E50.8 Other manifestations of vitamin A deficiency
0.000 0.555 0.445
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.555 0.445
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.555 0.445
E50.5 Vitamin A deficiency with night blindness
0.000 0.555 0.445
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.555 0.445
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.555 0.445
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.555 0.445
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.555 0.445
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.555 0.445
E51.9 Thiamine deficiency, unspecified
0.000 0.555 0.445
E51.8 Other manifestations of thiamine deficiency
0.000 0.555 0.445
E51.2 Wernicke's encephalopathy
0.000 0.555 0.445
E51.1 Beriberi
0.000 0.555 0.445
E56.9 Vitamin deficiency, unspecified
0.000 0.555 0.445
E56.8 Deficiency of other vitamins
0.000 0.555 0.445
E56.1 Deficiency of vitamin K
0.000 0.555 0.445
E56.0 Deficiency of vitamin E
0.000 0.555 0.445
E63.9 Nutritional deficiency, unspecified
0.000 0.555 0.445
E63.8 Other specified nutritional deficiencies
0.000 0.555 0.445
E63.1 Imbalance of constituents of food intake
0.000 0.555 0.445
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.555 0.445
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.555 0.445
E64.8 Sequelae of other nutritional deficiencies
0.000 0.555 0.445
E64.3 Sequelae of rickets
0.000 0.555 0.445
E64.2 Sequelae of vitamin C deficiency
0.000 0.555 0.445
E64.1 Sequelae of vitamin A deficiency
0.000 0.555 0.445
E64.0 Sequelae of protein-energy malnutrition
0.000 0.555 0.445
I33.9 Acute endocarditis, unspecified
0.000 0.555 0.445
E14.1 With ketoacidosis
0.000 0.557 0.443
E07.1 Dyshormogenetic goitre
0.000 0.570 0.430
E07.0 Hypersecretion of calcitonin
0.000 0.570 0.430
I30 Acute pericarditis
0.001 0.570 0.429
E14.5 With peripheral circulatory complications
0.000 0.576 0.424
E26.9 Hyperaldosteronism, unspecified
0.000 0.576 0.423
E14.7 With multiple complications
0.000 0.577 0.423
E14.2 Withrenal complications
0.000 0.577 0.423
E14.0 With coma
0.000 0.577 0.423
I24.0 Coronary thrombosis not resulting in myocardial infarction
0.000 0.579 0.421
E55.0 Rickets, active
0.000 0.580 0.420
I05-I09 Chronic rheumatic heart diseases
0.000 0.587 0.413
I36.9 Nonrheumatic tricuspid valve disorder, unspecified
0.000 0.587 0.412
I36.8 Other nonrheumatic tricuspid valve disorders
0.000 0.587 0.412
I36.2 Nonrheumatic tricuspid (valve) stenosis with insufficiency
0.000 0.587 0.412
I36.0 Nonrheumatic tricuspid (valve) stenosis
0.000 0.587 0.412
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.001 0.588 0.411
I33.0 Acute and subacute infective endocarditis
0.000 0.589 0.411
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.591 0.408
E07.8 Other specified disorders of thyroid
0.000 0.597 0.403
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.599 0.401
E45 Retarded development following protein-energy malnutrition
0.000 0.599 0.401
E43 Unspecified severe protein-energy malnutrition
0.000 0.599 0.401
E42 Marasmic kwashiorkor
0.000 0.599 0.401
E41 Nutritional marasmus
0.000 0.599 0.401
E40 Kwashiorkor
0.000 0.599 0.401
I11.0 Hypertensive heart disease with (congestive) heart failure
0.000 0.601 0.399
E26.0 Primary hyperaldosteronism
0.000 0.606 0.394
I49.1 Atrial premature depolarisation
0.000 0.606 0.394
I15.8 Other secondary hypertension
0.000 0.607 0.392
I15.2 Hypertension secondary to endocrine disorders
0.000 0.607 0.392
I15.0 Renovascular hypertension
0.000 0.607 0.392
E29.9 Testicular dysfunction, unspecified
0.000 0.609 0.391
E29.8 Other testicular dysfunction
0.000 0.609 0.391
E29.0 Testicular hyperfunction
0.000 0.609 0.391
I50.0 Congestive heart failure
0.000 0.616 0.384
E55.9 Vitamin D deficiency, unspecified
0.000 0.616 0.384
E16.1 Other hypoglycaemia
0.000 0.617 0.383
I38 Endocarditis, valve unspecified
0.000 0.624 0.376
I35.1 Aortic (valve) insufficiency
0.000 0.628 0.372
E65-E68 Obesity and other hyperalimentation
0.000 0.628 0.372
I40.8 Other acute myocarditis
0.000 0.632 0.368
I40.1 Isolated myocarditis
0.000 0.632 0.368
I01.9 Acute rheumatic heart disease, unspecified
0.000 0.636 0.364
I01.8 Other acute rheumatic heart disease
0.000 0.636 0.364
I01.2 Acute rheumatic myocarditis
0.000 0.636 0.364
I01.1 Acute rheumatic endocarditis
0.000 0.636 0.364
I01.0 Acute rheumatic pericarditis
0.000 0.636 0.364
I02.9 Rheumatic chorea without heart involvement
0.000 0.636 0.364
I02.0 Rheumatic chorea with heart involvement
0.000 0.636 0.364
E07.9 Disorder of thyroid, unspecified
0.000 0.644 0.356
I40.9 Acute myocarditis, unspecified
0.001 0.651 0.349
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.652 0.347
E24.3 Ectopic ACTH syndrome
0.000 0.652 0.347
E24.1 Nelson's syndrome
0.000 0.652 0.347
E13.8 With unspecified complications
0.000 0.658 0.341
E13.7 With multiple complications
0.000 0.658 0.341
E13.6 With other specified complications
0.000 0.658 0.341
E13.5 With peripheral circulatory complications
0.000 0.658 0.341
E13.4 With neurological complications
0.000 0.658 0.341
E13.2 With renal complications
0.000 0.658 0.341
E13.1 With ketoacidosis
0.000 0.658 0.341
E13.0 With coma
0.000 0.658 0.341
I12 Hypertensive renal disease
0.000 0.659 0.341
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.660 0.340
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.660 0.340
E16.4 Abnormal secretion of gastrin
0.000 0.660 0.340
E16.3 Increased secretion of glucagon
0.000 0.660 0.340
E24.0 Pituitary-dependent Cushing's disease
0.000 0.661 0.338
I36.1 Nonrheumatic tricuspid (valve) insufficiency
0.000 0.667 0.333
I15.9 Seconday hypertension, unspecified
0.000 0.670 0.329
I31 Other diseases of pericardium
0.000 0.672 0.328
I15.1 Hypertension secondary to other renal disorders
0.000 0.676 0.323
I20.1 Angina pectoris with documented spasm
0.000 0.676 0.323
E24.2 Drug-induced Cushing's syndrome
0.000 0.680 0.320
E16.2 Hypoglycaemia, unspecified
0.000 0.682 0.318
I11.9 Hypertensive heart disease without (congestive) heart failure
0.000 0.684 0.316
E24.8 Other Cushing's syndrome
0.001 0.687 0.312
E13.3 With ophthalmic complications
0.000 0.690 0.310
E14.8 With unspecified complications
0.000 0.691 0.309
I30.8 Other forms of acute pericarditis
0.001 0.691 0.308
I30.0 Acute nonspecific idiopathic pericarditis
0.001 0.691 0.308
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation
0.001 0.696 0.304
I45 Other conduction disorders
0.000 0.700 0.300
I30.1 Infective pericarditis
0.001 0.700 0.299
E44.1 Mild protein-energy malnutrition
0.000 0.712 0.287
E44.0 Moderate protein-energy malnutrition
0.000 0.712 0.287
I06 Rheumatic aortic valve diseases
0.000 0.714 0.286
I07 Rheumatic tricuspid valve diseases
0.000 0.714 0.285
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.721 0.279
I05 Rheumatic mitral valve diseases
0.000 0.722 0.278
E67 Other hyperalimentation
0.000 0.733 0.266
E68 Sequelae of hyperalimentation
0.000 0.733 0.266
I46 Cardiac arrest
0.000 0.735 0.265
I20.0 Unstable angina
0.000 0.737 0.263
I40.0 Infective myocarditis
0.001 0.740 0.259
E24.9 Cushing's syndrome, unspecified
0.001 0.742 0.258
I09 Other rheumatic heart diseases
0.000 0.751 0.249
E46 Unspecified protein-energy malnutrition
0.000 0.753 0.247
I31.1 Chronic constrictive pericarditis
0.000 0.753 0.247
I31.0 Chronic adhesive pericarditis
0.000 0.757 0.243
I45.6 Preexcitation syndrome
0.000 0.758 0.242
I95 Hypotension
0.000 0.764 0.236
I31.8 Other specified diseases of pericardium
0.000 0.764 0.235
I31.2 Haemopericardium, not elsewhere classified
0.000 0.764 0.235
I45.9 Conduction disorder, unspecified
0.000 0.766 0.234
I45.4 Nonspecific intraventricular block
0.000 0.774 0.226
E29.1 Testicular hypofunction
0.001 0.776 0.223
E14.9 Without complications
0.000 0.777 0.223
I05.0 Mitral stenosis
0.000 0.778 0.222
E65 Localised adiposity
0.000 0.782 0.218
I45.8 Other specified conduction disorders
0.000 0.784 0.216
I45.0 Right fascicular block
0.000 0.785 0.215
I05.2 Mitral stenosis with insufficiency
0.000 0.787 0.213
I80-I89 Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified
0.000 0.790 0.210
I06.9 Rheumatic aortic valve disease, unspecified
0.000 0.795 0.205
I06.8 Other rheumatic aortic valve diseases
0.000 0.795 0.205
I06.2 Rheumatic aortic stenosis with insufficiency
0.000 0.795 0.205
I06.0 Rheumatic aortic stenosis
0.000 0.795 0.205
I07.9 Tricuspid valve disease, unspecified
0.000 0.795 0.205
I07.8 Other tricuspid valve diseases
0.000 0.795 0.205
I07.2 Tricuspid stenosis with insufficiency
0.000 0.795 0.205
I07.0 Tricuspid stenosis
0.000 0.795 0.205
I95.2 Hypotension due to drugs
0.000 0.795 0.205
I49.8 Other specified cardiac arrhythmias
0.001 0.796 0.204
I28 Other diseases of pulmonary vessels
0.001 0.798 0.201
I08 Multiple valve diseases
0.000 0.800 0.200
I05.8 Other mitral valve diseases
0.000 0.800 0.200
E13.9 Without complications
0.001 0.801 0.199
I06.1 Rheumatic aortic insufficiency
0.000 0.806 0.194
I07.1 Tricuspid insufficiency
0.000 0.806 0.194
I05.1 Rheumatic mitral insufficiency
0.000 0.807 0.193
E67.8 Other specified hyperalimentation
0.000 0.809 0.191
E67.3 Hypervitaminosis D
0.000 0.809 0.191
E67.2 Megavitamin-B6 syndrome
0.000 0.809 0.191
E67.1 Hypercarotenaemia
0.000 0.809 0.191
E67.0 Hypervitaminosis A
0.000 0.809 0.191
I46.1 Sudden cardiac death, so described
0.000 0.810 0.190
I12.9 Hypertensive renal disease without renal failure
0.000 0.811 0.189
I45.2 Bifascicular block
0.000 0.811 0.189
I45.5 Other specified heart block
0.000 0.815 0.185
I09.8 Other specified rheumatic heart diseases
0.000 0.821 0.178
I09.2 Chronic rheumatic pericarditis
0.000 0.821 0.178
I09.1 Rheumatic diseases of endocardium, valve unspecified
0.000 0.821 0.178
I09.0 Rheumatic myocarditis
0.000 0.821 0.178
I44 Atrioventricular and left bundle-branch block
0.000 0.823 0.177
E04 Other non-toxic goitre
0.000 0.824 0.176

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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