TreeWAS – Variant ID: rs10466829

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

Hierarchical visualisation How to interpret this figure?

Click here to show this figure without filtering.

Click on a node to zoom (except terminal nodes).

Download this figure in format

Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
E03.9 Hypothyroidism, unspecified	0.000	0.000	1.000
E10 Insulin-dependent diabetes mellitus	0.000	0.000	1.000
E10-E14 Diabetes mellitus	0.000	0.001	0.999
E00-E07 Disorders of thyroid gland	0.000	0.001	0.999
Chapter IV Endocrine, nutritional and metabolic diseases	0.000	0.001	0.999
E03 Other hypothyroidism	0.000	0.001	0.999
E10.3 With ophthalmic complications	0.000	0.001	0.999
E20-E35 Disorders of other endocrine glands	0.000	0.005	0.995
E10.5 With peripheral circulatory complications	0.000	0.008	0.992
E27 Other disorders of adrenal gland	0.000	0.035	0.965
E34 Other endocrine disorders	0.000	0.044	0.956
E06 Thyroiditis	0.000	0.054	0.946
E10.9 Without complications	0.000	0.062	0.938
E22 Hyperfunction of pituitary gland	0.000	0.066	0.934
E10.1 With ketoacidosis	0.000	0.070	0.930
E34.9 Endocrine disorder, unspecified	0.000	0.080	0.920
E06.3 Autoimmune thyroiditis	0.000	0.087	0.913
E10.4 With neurological complications	0.000	0.090	0.910
E07 Other disorders of thyroid	0.000	0.090	0.910
E27.1 Primary adrenocortical insufficiency	0.000	0.110	0.890
E10.2 With renal complications	0.000	0.141	0.859
E20 Hypoparathyroidism	0.000	0.145	0.855
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone	0.000	0.158	0.842
E10.8 With unspecified complications	0.000	0.160	0.840
E07.8 Other specified disorders of thyroid	0.000	0.170	0.830
E10.0 With coma	0.000	0.178	0.822
E27.9 Disorder of adrenal gland, unspecified	0.000	0.180	0.820
E22.1 Hyperprolactinaemia	0.000	0.182	0.818
E13 Other specified diabetes mellitus	0.000	0.189	0.811
E25 Adrenogenital disorders	0.000	0.199	0.801
E34.0 Carcinoid syndrome	0.000	0.221	0.779
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion	0.000	0.230	0.770
E02 Subclinical iodine-deficiency hypothyroidism	0.000	0.233	0.767
E27.2 Addisonian crisis	0.000	0.244	0.755
E20.9 Hypoparathyroidism, unspecified	0.000	0.245	0.754
E06.5 Other chronic thyroiditis	0.000	0.264	0.736
E24 Cushing's syndrome	0.000	0.271	0.729
E34.3 Short stature, not elsewhere classified	0.000	0.274	0.726
E27.4 Other and unspecified adrenocortical insufficiency	0.000	0.277	0.723
E27.8 Other specified disorders of adrenal gland	0.000	0.282	0.718
E10.7 With multiple complications	0.000	0.283	0.717
E12 Malnutrition-related diabetes mellitus	0.000	0.284	0.716
E01 Iodine-deficiency-related thyroid disorders and allied conditions	0.000	0.284	0.716
E00 Congenital iodine-deficiency syndrome	0.000	0.284	0.716
E03.5 Myxoedema coma	0.000	0.284	0.716
E03.4 Atrophy of thyroid (acquired)	0.000	0.284	0.716
E03.3 Postinfectious hypothyroidism	0.000	0.284	0.716
E27.3 Drug-induced adrenocortical insufficiency	0.000	0.284	0.716
E35 Disorders of endocrine glands in diseases classified elsewhere	0.000	0.286	0.714
E32 Diseases of thymus	0.000	0.286	0.714
E30 Disorders of puberty, not elsewhere classified	0.000	0.286	0.714
E03.2 Hypothyroidism due to medicaments and other exogenous substances	0.000	0.287	0.712
E07.9 Disorder of thyroid, unspecified	0.000	0.296	0.704
E13.9 Without complications	0.000	0.303	0.697
E27.5 Adrenomedullary hyperfunction	0.000	0.308	0.691
E27.0 Other adrenocortical overactivity	0.000	0.308	0.691
E06.1 Subacute thyroiditis	0.000	0.309	0.691
E34.5 Androgen resistance syndrome	0.000	0.314	0.685
E34.4 Constitutional tall stature	0.000	0.314	0.685
E34.2 Ectopic hormone secretion, not elsewhere classified	0.000	0.314	0.685
E34.1 Other hypersecretion of intestinal hormones	0.000	0.314	0.685
E06.4 Drug-induced thyroiditis	0.000	0.322	0.678
E06.2 Chronic thyroiditis with transient thyrotoxicosis	0.000	0.322	0.678
E06.0 Acute thyroiditis	0.000	0.322	0.678
E22.9 Hyperfunction of pituitary gland, unspecified	0.000	0.330	0.670
E22.8 Other hyperfunction of pituitary gland	0.000	0.330	0.670
E31 Polyglandular dysfunction	0.000	0.338	0.662
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency	0.000	0.338	0.662
E28 Ovarian dysfunction	0.000	0.343	0.657
E07.1 Dyshormogenetic goitre	0.000	0.348	0.652
E07.0 Hypersecretion of calcitonin	0.000	0.348	0.652
E22.0 Acromegaly and pituitary gigantism	0.000	0.353	0.647
E03.0 Congenital hypothyroidism with diffuse goitre	0.000	0.361	0.639
E40-E46 Malnutrition	0.000	0.367	0.633
E24.9 Cushing's syndrome, unspecified	0.000	0.378	0.622
E20.8 Other hypoparathyroidism	0.000	0.387	0.613
E20.1 Pseudohypoparathyroidism	0.000	0.387	0.613
E20.0 Idiopathic hypoparathyroidism	0.000	0.387	0.613
E03.8 Other specified hypothyroidism	0.000	0.393	0.607
E16 Other disorders of pancreatic internal secretion	0.000	0.394	0.606
E13.8 With unspecified complications	0.000	0.418	0.582
E13.7 With multiple complications	0.000	0.418	0.582
E13.6 With other specified complications	0.000	0.418	0.582
E13.5 With peripheral circulatory complications	0.000	0.418	0.582
E13.4 With neurological complications	0.000	0.418	0.582
E13.2 With renal complications	0.000	0.418	0.582
E13.1 With ketoacidosis	0.000	0.418	0.582
E13.0 With coma	0.000	0.418	0.582
E34.8 Other specified endocrine disorders	0.000	0.421	0.579
E21 Hyperparathyroidism and other disorders of parathyroid gland	0.000	0.424	0.576
E29 Testicular dysfunction	0.000	0.424	0.575
E14 Unspecified diabetes mellitus	0.000	0.425	0.575
E25.9 Adrenogenital disorder, unspecified	0.000	0.426	0.574
E25.8 Other adrenogenital disorders	0.000	0.426	0.574
E15 Nondiabetic hypoglycaemic coma	0.000	0.448	0.552
E03.1 Congenital hypothyroidism without goitre	0.000	0.457	0.543
E13.3 With ophthalmic complications	0.000	0.458	0.542
E26 Hyperaldosteronism	0.000	0.463	0.537
E06.9 Thyroiditis, unspecified	0.000	0.464	0.536
E24.8 Other Cushing's syndrome	0.000	0.477	0.522
E24.4 Alcohol-induced pseudo-Cushing's syndrome	0.000	0.477	0.522
E24.3 Ectopic ACTH syndrome	0.000	0.477	0.522
E24.1 Nelson's syndrome	0.000	0.477	0.522
E23 Hypofunction and other disorders of pituitary gland	0.000	0.481	0.519
E28.3 Primary ovarian failure	0.000	0.484	0.516
E00.9 Congenital iodine-deficiency syndrome, unspecified	0.000	0.486	0.514
E00.2 Congenital iodine-deficiency syndrome, mixed type	0.000	0.486	0.514
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type	0.000	0.486	0.514
E00.0 Congenital iodine-deficiency syndrome, neurological type	0.000	0.486	0.514
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions	0.000	0.486	0.514
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified	0.000	0.486	0.514
E01.1 Iodine-deficiency-related multinodular (endemic) goitre	0.000	0.486	0.514
E01.0 Iodine-deficiency-related diffuse (endemic) goitre	0.000	0.486	0.514
E12.9 Without complications	0.000	0.486	0.514
E12.8 With unspecified complications	0.000	0.486	0.514
E12.7 With multiple complications	0.000	0.486	0.514
E12.6 With other specified complications	0.000	0.486	0.514
E12.5 With peripheral circulatory complications	0.000	0.486	0.514
E12.4 With neurological complications	0.000	0.486	0.514
E12.3 With ophthalmic complications	0.000	0.486	0.514
E12.2 With renal complications	0.000	0.486	0.514
E12.1 With ketoacidosis	0.000	0.486	0.514
E12.0 With coma	0.000	0.486	0.514
E30.9 Disorder of puberty, unspecified	0.000	0.488	0.512
E30.8 Other disorders of puberty	0.000	0.488	0.512
E30.1 Precocious puberty	0.000	0.488	0.512
E30.0 Delayed puberty	0.000	0.488	0.512
E32.9 Disease of thymus, unspecified	0.000	0.488	0.512
E32.8 Other diseases of thymus	0.000	0.488	0.512
E32.1 Abscess of thymus	0.000	0.488	0.512
E32.0 Persistent hyperplasia of thymus	0.000	0.488	0.512
E35.8 Disorders of other endocrine glands in diseases classified elsewhere	0.000	0.488	0.512
E35.1 Disorders of adrenal glands in diseases classified elsewhere	0.000	0.488	0.512
E35.0 Disorders of thyroid gland in diseases classified elsewhere	0.000	0.488	0.512
E14.6 With other specified complications	0.000	0.493	0.507
E21.1 Secondary hyperparathyroidism, not elsewhere classified	0.000	0.499	0.501
E16.2 Hypoglycaemia, unspecified	0.000	0.507	0.493
E10.6 With other specified complications	0.001	0.516	0.483
E31.9 Polyglandular dysfunction, unspecified	0.000	0.525	0.475
E31.8 Other polyglandular dysfunction	0.000	0.525	0.475
E31.1 Polyglandular hyperfunction	0.000	0.525	0.475
E14.2 Withrenal complications	0.000	0.526	0.474
E28.9 Ovarian dysfunction, unspecified	0.000	0.529	0.471
E28.8 Other ovarian dysfunction	0.000	0.529	0.471
E28.1 Androgen excess	0.000	0.529	0.471
E28.0 Oestrogen excess	0.000	0.529	0.471
E16.1 Other hypoglycaemia	0.000	0.530	0.469
E23.2 Diabetes insipidus	0.000	0.543	0.457
E24.0 Pituitary-dependent Cushing's disease	0.000	0.545	0.455
E44 Protein-energy malnutrition of moderate and mild degree	0.000	0.546	0.454
E45 Retarded development following protein-energy malnutrition	0.000	0.546	0.454
E43 Unspecified severe protein-energy malnutrition	0.000	0.546	0.454
E42 Marasmic kwashiorkor	0.000	0.546	0.454
E41 Nutritional marasmus	0.000	0.546	0.454
E40 Kwashiorkor	0.000	0.546	0.454
E50-E64 Other nutritional deficiencies	0.000	0.547	0.453
E24.2 Drug-induced Cushing's syndrome	0.000	0.549	0.451
E21.2 Other hyperparathyroidism	0.000	0.549	0.451
E16.9 Disorder of pancreatic internal secretion, unspecified	0.000	0.566	0.434
E16.8 Other specified disorders of pancreatic internal secretion	0.000	0.566	0.434
E16.4 Abnormal secretion of gastrin	0.000	0.566	0.434
E16.3 Increased secretion of glucagon	0.000	0.566	0.434
E14.5 With peripheral circulatory complications	0.000	0.571	0.429
E31.0 Autoimmune polyglandular failure	0.000	0.577	0.423
E21.4 Other specified disorders of parathyroid gland	0.000	0.579	0.421
E29.8 Other testicular dysfunction	0.000	0.587	0.413
E29.0 Testicular hyperfunction	0.000	0.587	0.413
E14.7 With multiple complications	0.000	0.587	0.412
E65-E68 Obesity and other hyperalimentation	0.000	0.588	0.412
E14.1 With ketoacidosis	0.000	0.606	0.394
E11 Non-insulin-dependent diabetes mellitus	0.000	0.607	0.393
E29.9 Testicular dysfunction, unspecified	0.000	0.611	0.389
E14.0 With coma	0.000	0.611	0.389
E26.8 Other hyperaldosteronism	0.000	0.615	0.385
E26.1 Secondary hyperaldosteronism	0.000	0.615	0.385
E16.0 Drug-induced hypoglycaemia without coma	0.000	0.620	0.380
E14.8 With unspecified complications	0.000	0.623	0.377
E23.1 Drug-induced hypopituitarism	0.000	0.627	0.372
E46 Unspecified protein-energy malnutrition	0.000	0.629	0.371
E14.4 With neurological complications	0.000	0.629	0.370
E21.5 Disorder of parathyroid gland, unspecified	0.000	0.636	0.363
E26.9 Hyperaldosteronism, unspecified	0.000	0.639	0.360
E61 Deficiency of other nutrient elements	0.000	0.643	0.357
E23.6 Other disorders of pituitary gland	0.000	0.645	0.355
E21.3 Hyperparathyroidism, unspecified	0.000	0.650	0.350
E11.2 With renal complications	0.000	0.658	0.342
E56 Other vitamin deficiencies	0.000	0.662	0.337
E28.2 Polycystic ovarian syndrome	0.000	0.664	0.336
E44.1 Mild protein-energy malnutrition	0.000	0.674	0.326
E44.0 Moderate protein-energy malnutrition	0.000	0.674	0.326
E64 Sequelae of malnutrition and other nutritional deficiencies	0.000	0.675	0.325
E50 Vitamin A deficiency	0.000	0.675	0.325
E60 Dietary zinc deficiency	0.000	0.675	0.325
E59 Dietary selenium deficiency	0.000	0.675	0.325
E52 Niacin deficiency [pellagra]	0.000	0.675	0.325
E11.6 With other specified complications	0.000	0.676	0.324
E23.3 Hypothalamic dysfunction, not elsewhere classified	0.000	0.679	0.321
E29.1 Testicular hypofunction	0.000	0.687	0.312
E11.5 With peripheral circulatory complications	0.000	0.689	0.311
E51 Thiamine deficiency	0.000	0.691	0.308
E11.1 With ketoacidosis	0.000	0.691	0.308
E54 Ascorbic acid deficiency	0.000	0.695	0.305
E63 Other nutritional deficiencies	0.000	0.697	0.303
E58 Dietary calcium deficiency	0.000	0.698	0.301
E61.1 Iron deficiency	0.000	0.704	0.296
E67 Other hyperalimentation	0.000	0.705	0.295
E68 Sequelae of hyperalimentation	0.000	0.705	0.295
E11.7 With multiple complications	0.000	0.718	0.282
E53 Deficiency of other B group vitamins	0.000	0.722	0.278
E14.3 With ophthalmic complications	0.000	0.736	0.264
E23.7 Disorder of pituitary gland, unspecified	0.000	0.736	0.264
E61.9 Deficiency of nutrient element, unspecified	0.000	0.744	0.256
E61.8 Deficiency of other specified nutrient elements	0.000	0.744	0.256
E61.7 Deficiency of multiple nutrient elements	0.000	0.744	0.256
E61.6 Vanadium deficiency	0.000	0.744	0.256
E61.5 Molybdenum deficiency	0.000	0.744	0.256
E61.4 Chromium deficiency	0.000	0.744	0.256
E61.3 Manganese deficiency	0.000	0.744	0.256
E61.0 Copper deficiency	0.000	0.744	0.256
E56.1 Deficiency of vitamin K	0.000	0.745	0.254
E26.0 Primary hyperaldosteronism	0.001	0.745	0.254
E61.2 Magnesium deficiency	0.000	0.758	0.242
E56.9 Vitamin deficiency, unspecified	0.000	0.758	0.242
E56.8 Deficiency of other vitamins	0.000	0.758	0.242
E56.0 Deficiency of vitamin E	0.000	0.758	0.242
E11.0 With coma	0.000	0.759	0.241
E11.8 With unspecified complications	0.000	0.762	0.238
E50.9 Vitamin A deficiency, unspecified	0.000	0.767	0.233
E50.8 Other manifestations of vitamin A deficiency	0.000	0.767	0.233
E50.7 Other ocular manifestations of vitamin A deficiency	0.000	0.767	0.233
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea	0.000	0.767	0.233
E50.5 Vitamin A deficiency with night blindness	0.000	0.767	0.233
E50.4 Vitamin A deficiency with keratomalacia	0.000	0.767	0.233
E50.3 Vitamin A deficiency with corneal ulceration and xerosis	0.000	0.767	0.233
E50.2 Vitamin A deficiency with corneal xerosis	0.000	0.767	0.233
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis	0.000	0.767	0.233
E50.0 Vitamin A deficiency with conjunctival xerosis	0.000	0.767	0.233
E64.9 Sequelae of unspecified nutritional deficiency	0.000	0.767	0.233
E64.8 Sequelae of other nutritional deficiencies	0.000	0.767	0.233
E64.3 Sequelae of rickets	0.000	0.767	0.233
E64.2 Sequelae of vitamin C deficiency	0.000	0.767	0.233
E64.1 Sequelae of vitamin A deficiency	0.000	0.767	0.233
E64.0 Sequelae of protein-energy malnutrition	0.000	0.767	0.233
E14.9 Without complications	0.000	0.774	0.226
E53.9 Vitamin B deficiency, unspecified	0.000	0.776	0.224
E51.9 Thiamine deficiency, unspecified	0.000	0.779	0.221
E51.8 Other manifestations of thiamine deficiency	0.000	0.779	0.221
E51.1 Beriberi	0.000	0.779	0.221
E55 Vitamin D deficiency	0.000	0.780	0.220
E63.8 Other specified nutritional deficiencies	0.000	0.782	0.217
E63.1 Imbalance of constituents of food intake	0.000	0.782	0.217
E63.0 Essential fatty acid [EFA] deficiency	0.000	0.782	0.217
E23.0 Hypopituitarism	0.000	0.784	0.216
E67.8 Other specified hyperalimentation	0.000	0.788	0.212
E67.3 Hypervitaminosis D	0.000	0.788	0.212
E67.2 Megavitamin-B6 syndrome	0.000	0.788	0.212
E67.1 Hypercarotenaemia	0.000	0.788	0.212
E67.0 Hypervitaminosis A	0.000	0.788	0.212
E65 Localised adiposity	0.000	0.793	0.207
E51.2 Wernicke's encephalopathy	0.000	0.795	0.205
E53.1 Pyridoxine deficiency	0.000	0.800	0.200
E53.0 Riboflavin deficiency	0.000	0.800	0.200
E63.9 Nutritional deficiency, unspecified	0.000	0.804	0.196
E11.4 With neurological complications	0.000	0.809	0.191
E66 Obesity	0.000	0.828	0.172
E55.0 Rickets, active	0.000	0.842	0.158
E66.0 Obesity due to excess calories	0.000	0.850	0.150
E05 Thyrotoxicosis [hyperthyroidism]	0.000	0.853	0.147
E66.1 Drug-induced obesity	0.000	0.876	0.123
E11.3 With ophthalmic complications	0.000	0.889	0.111
E04 Other non-toxic goitre	0.000	0.890	0.109
E05.5 Thyroid crisis or storm	0.000	0.894	0.106
E05.4 Thyrotoxicosis factitia	0.000	0.894	0.106
E05.3 Thyrotoxicosis from ectopic thyroid tissue	0.000	0.894	0.106
E66.8 Other obesity	0.000	0.899	0.101
E05.2 Thyrotoxicosis with toxic multinodular goitre	0.000	0.901	0.098
E53.8 Deficiency of other specified B group vitamins	0.000	0.904	0.096
E66.2 Extreme obesity with alveolar hypoventilation	0.000	0.904	0.096
E21.0 Primary hyperparathyroidism	0.000	0.914	0.086
E05.1 Thyrotoxicosis with toxic single thyroid nodule	0.000	0.914	0.086
E11.9 Without complications	0.000	0.915	0.085
E04.8 Other specified non-toxic goitre	0.000	0.921	0.078
E05.8 Other thyrotoxicosis	0.000	0.927	0.072
E04.0 Non-toxic diffuse goitre	0.000	0.928	0.071
E05.0 Thyrotoxicosis with diffuse goitre	0.000	0.934	0.066
E04.2 Non-toxic multinodular goitre	0.000	0.944	0.056
E55.9 Vitamin D deficiency, unspecified	0.000	0.947	0.053
E05.9 Thyrotoxicosis, unspecified	0.000	0.954	0.046
E04.9 Non-toxic goitre, unspecified	0.000	0.981	0.019
K51.2 Ulcerative (chronic) proctitis	0.000	0.991	0.009
N75.0 Cyst of Bartholin's gland	0.000	0.992	0.008
E04.1 Non-toxic single thyroid nodule	0.002	0.992	0.006
M22.4 Chondromalacia patellae	0.000	0.993	0.007
Z63.8 Other specified problems related to primary support group	0.007	0.993	0.000
D12.6 Colon, unspecified	0.000	0.993	0.007
N45.9 Orchitis, epididymitis and epididymo-orchitis without abscess	0.000	0.993	0.007
M22.8 Other disorders of patella	0.000	0.993	0.007
R93.7 Abnormal findings on diagnostic imaging of other parts of musculoskeletal system	0.007	0.993	0.000
Z63.7 Other stressful life events affecting family and household	0.006	0.994	0.000
M19.07 Primary arthrosis of other joints (Ankle and foot)	0.006	0.994	0.000
Z63 Other problems related to primary support group, including family circumstances	0.006	0.994	0.000
M22 Disorders of patella	0.000	0.994	0.006
M22.9 Disorder of patella, unspecified	0.000	0.994	0.006
Z63.6 Dependent relative needing care at home	0.005	0.995	0.000
S32.00 Fracture of lumbar vertebra (closed)	0.000	0.995	0.005
R80 Isolated proteinuria	0.005	0.995	0.000
K11.8 Other diseases of salivary glands	0.005	0.995	0.000
S01.3 Open wound of ear	0.005	0.995	0.000
E66.9 Obesity, unspecified	0.000	0.995	0.005
S00.8 Superficial injury of other parts of head	0.005	0.995	0.000
Z63.9 Problem related to primary support group, unspecified	0.004	0.995	0.000
Z63.3 Absence of family member	0.004	0.995	0.000
Z63.2 Inadequate family support	0.004	0.995	0.000
Z63.1 Problems in relationship with parents and in-laws	0.004	0.995	0.000
M22.1 Recurrent subluxation of patella	0.000	0.995	0.004
S32.0 Fracture of lumbar vertebra	0.000	0.995	0.004
E70-E90 Metabolic disorders	0.000	0.995	0.005
Z63.4 Disappearance and death of family member	0.004	0.996	0.000
Z50.5 Speech therapy	0.004	0.996	0.000
Z63.5 Disruption of family by separation and divorce	0.004	0.996	0.000
H52.3 Anisometropia and aniseikonia	0.000	0.996	0.004
E85 Amyloidosis	0.000	0.996	0.004
C50.3 Lower-inner quadrant of breast	0.000	0.996	0.004
S32.50 Fracture of pubis (closed)	0.000	0.996	0.004
Z63.0 Problems in relationship with spouse or partner	0.004	0.996	0.000
M22.3 Other derangements of patella	0.000	0.996	0.004
M22.0 Recurrent dislocation of patella	0.000	0.996	0.004
S91.1 Open wound of toe(s) without damage to nail	0.000	0.996	0.004
S32.5 Fracture of pubis	0.000	0.996	0.004
S32 Fracture of lumbar spine and pelvis	0.000	0.996	0.004
E85.4 Organ-limited amyloidosis	0.000	0.996	0.004
S01.7 Multiple open wounds of head	0.000	0.996	0.004
E84 Cystic fibrosis	0.000	0.996	0.004
E85.3 Secondary systemic amyloidosis	0.000	0.996	0.004
S32.4 Fracture of acetabulum	0.000	0.996	0.004
S65.1 Injury of radial artery at wrist and hand level	0.004	0.996	0.000
E70 Disorders of aromatic amino-acid metabolism	0.000	0.996	0.004
M75.9 Shoulder lesion, unspecified	0.000	0.996	0.004
E75 Disorders of sphingolipid metabolism and other lipid storage disorders	0.000	0.996	0.004
E85.8 Other amyloidosis	0.000	0.996	0.003
K27.9 Unspecified as acute or chronic, without haemorrhage or perforation	0.004	0.996	0.000
M22.10 Recurrent subluxation of patella, unspecified knee	0.000	0.996	0.003
S32.40 Fracture of acetabulum (closed)	0.000	0.996	0.004
S32.01 Fracture of lumbar vertebra (open)	0.000	0.996	0.003
S32.7 Multiple fractures of lumbar spine and pelvis	0.000	0.996	0.003
E77 Disorders of glycoprotein metabolism	0.000	0.996	0.003
E76 Disorders of glycosaminoglycan metabolism	0.000	0.996	0.003
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism	0.000	0.996	0.003
E90 Nutritional and metabolic disorders in diseases classified elsewhere	0.000	0.996	0.003
C45.0 Mesothelioma of pleura	0.000	0.997	0.003
Z37.2 Twins, both liveborn	0.000	0.997	0.003
S65 Injury of blood vessels at wrist and hand level	0.003	0.997	0.000
S65.5 Injury of blood vessel(s) of other finger	0.003	0.997	0.000
E74 Other disorders of carbohydrate metabolism	0.000	0.997	0.003
S05.0 Injury of conjunctiva and corneal abrasion without mention of foreign body	0.003	0.997	0.000
E72 Other disorders of amino-acid metabolism	0.000	0.997	0.003
S32.70 Multiple fractures of lumbar spine and pelvis (closed)	0.000	0.997	0.003
E85.2 Heredofamilial amyloidosis, unspecified	0.000	0.997	0.003
E85.1 Neuropathic heredofamilial amyloidosis	0.000	0.997	0.003
E85.0 Nonneuropathic heredofamilial amyloidosis	0.000	0.997	0.003
S62.20 Fracture of first metacarpal bone (closed)	0.003	0.997	0.000
L73.2 Hidradenitis suppurativa	0.000	0.997	0.003
C45 Mesothelioma	0.000	0.997	0.003
S32.1 Fracture of sacrum	0.000	0.997	0.003
S62.40 Multiple fractures of metacarpal bones (closed)	0.003	0.997	0.000
E79 Disorders of purine and pyrimidine metabolism	0.000	0.997	0.003
C45.9 Mesothelioma, unspecified	0.000	0.997	0.003
M22.2 Patellofemoral disorders	0.000	0.997	0.003
C45.7 Mesothelioma of other sites	0.000	0.997	0.003
C21.1 Anal canal	0.003	0.997	0.000
E84.9 Cystic fibrosis, unspecified	0.000	0.997	0.003
F45.8 Other somatoform disorders	0.003	0.997	0.000
S62.71 Multiple fractures of fingers (open)	0.003	0.997	0.000
M54.96 Dorsalgia, unspecified (Lumbar region)	0.003	0.997	0.000
S32.51 Fracture of pubis (open)	0.000	0.997	0.003
S65.4 Injury of blood vessel(s) of thumb	0.003	0.997	0.000
T43.3 Phenothiazine antipsychotics and neuroleptics	0.003	0.997	0.000
S32.2 Fracture of coccyx	0.000	0.997	0.003
E85.9 Amyloidosis, unspecified	0.000	0.997	0.003
E70.3 Albinism	0.000	0.997	0.003
S62.7 Multiple fractures of fingers	0.003	0.997	0.000
E75.5 Other lipid storage disorders	0.000	0.997	0.003
I77.6 Arteritis, unspecified	0.003	0.997	0.000
S62.2 Fracture of first metacarpal bone	0.003	0.997	0.000
T46.4 Angiotensin-converting-enzyme inhibitors	0.003	0.997	0.000
E84.8 Cystic fibrosis with other manifestations	0.000	0.997	0.003
E84.1 Cystic fibrosis with intestinal manifestations	0.000	0.997	0.003
E84.0 Cystic fibrosis with pulmonary manifestations	0.000	0.997	0.003
E80 Disorders of porphyrin and bilirubin metabolism	0.000	0.997	0.003
S62.4 Multiple fractures of metacarpal bones	0.003	0.997	0.000
E70.9 Disorder of aromatic amino-acid metabolism, unspecified	0.000	0.997	0.003
E70.8 Other disorders of aromatic amino-acid metabolism	0.000	0.997	0.003
E70.2 Disorders of tyrosine metabolism	0.000	0.997	0.003
E70.1 Other hyperphenylalaninaemias	0.000	0.997	0.003
E70.0 Classical phenylketonuria	0.000	0.997	0.003
S32.41 Fracture of acetabulum (open)	0.000	0.997	0.003
E75.6 Lipid storage disorder, unspecified	0.000	0.997	0.003
E75.4 Neuronal ceroid lipofuscinosis	0.000	0.997	0.003
E75.3 Sphingolipidosis, unspecified	0.000	0.997	0.003
E75.2 Other sphingolipidosis	0.000	0.997	0.003
E75.1 Other gangliosidosis	0.000	0.997	0.003
E75.0 GM2 gangliosidosis	0.000	0.997	0.003
S05 Injury of eye and orbit	0.003	0.997	0.000
E74.0 Glycogen storage disease	0.000	0.997	0.003
S64.3 Injury of digital nerve of thumb	0.003	0.997	0.000
S72.40 Fracture of lower end of femur (closed)	0.003	0.997	0.000
S05.1 Contusion of eyeball and orbital tissues	0.003	0.997	0.000
S32.10 Fracture of sacrum (closed)	0.000	0.997	0.003
E71.3 Disorders of fatty-acid metabolism	0.000	0.997	0.003
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified	0.000	0.997	0.003
E71.1 Other disorders of branched-chain amino-acid metabolism	0.000	0.997	0.003
E71.0 Maple-syrup-urine disease	0.000	0.997	0.003
E76.9 Disorder of glucosaminoglycan metabolism, unspecified	0.000	0.997	0.003
E76.8 Other disorders of glucosaminoglycan metabolism	0.000	0.997	0.003
E76.3 Mucopolysaccharidosis, unspecified	0.000	0.997	0.003
E76.2 Other mucopolysaccharidoses	0.000	0.997	0.003
E76.1 Mucopolysaccharidosis, type II	0.000	0.997	0.003
E76.0 Mucopolysaccharidosis, type I	0.000	0.997	0.003
E77.9 Disorder of glycoprotein metabolism, unspecified	0.000	0.997	0.003
E77.8 Other disorders of glycoprotein metabolism	0.000	0.997	0.003
E77.1 Defects in glycoprotein degradation	0.000	0.997	0.003
E77.0 Defects in posttranslational modification of lysosomal enzymes	0.000	0.997	0.003
S05.9 Injury of eye and orbit, part unspecified	0.003	0.997	0.000
S32.71 Multiple fractures of lumbar spine and pelvis (open)	0.000	0.997	0.003
S65.9 Injury of unspecified blood vessel at wrist and hand level	0.003	0.997	0.000
S65.8 Injury of other blood vessels at wrist and hand level	0.003	0.997	0.000
S65.7 Injury of multiple blood vessels at wrist and hand level	0.003	0.997	0.000
S65.3 Injury of deep palmar arch	0.003	0.997	0.000
S65.2 Injury of superficial palmar arch	0.003	0.997	0.000
E73 Lactose intolerance	0.000	0.997	0.003
S65.0 Injury of ulnar artery at wrist and hand level	0.003	0.997	0.000
I11.9 Hypertensive heart disease without (congestive) heart failure	0.000	0.997	0.003
K60.3 Anal fistula	0.003	0.997	0.000
S62 Fracture at wrist and hand level	0.003	0.997	0.000
E74.9 Disorder of carbohydrate metabolism, unspecified	0.000	0.997	0.003
E74.8 Other specified disorders of carbohydrate metabolism	0.000	0.997	0.003
E74.4 Disorders of pyruvate metabolism and gluconeogenesis	0.000	0.997	0.003
E74.2 Disorders of galactose metabolism	0.000	0.997	0.003
E74.1 Disorders of fructose metabolism	0.000	0.997	0.003
S64.4 Injury of digital nerve of other finger	0.003	0.997	0.000
S63 Dislocation, sprain and strain of joints and ligaments at wrist and hand level	0.003	0.997	0.000
S62.70 Multiple fractures of fingers (closed)	0.003	0.997	0.000
E80.2 Other porphyria	0.000	0.997	0.003
S32.8 Fracture of other and unspecified parts of lumbar spine and pelvis	0.000	0.997	0.003
T46 Poisoning by agents primarily affecting the cardiovascular system	0.003	0.997	0.000
M80.00 Postmenopausal osteoporosis with pathological fracture (Multiple sites)	0.000	0.997	0.003
E72.9 Disorder of amino-acid metabolism, unspecified	0.000	0.997	0.002
E72.8 Other specified disorders of amino-acid metabolism	0.000	0.997	0.002
E72.5 Disorders of glycine metabolism	0.000	0.997	0.002
E72.4 Disorders of ornithine metabolism	0.000	0.997	0.002
E72.3 Disorders of lysine and hydroxylysine metabolism	0.000	0.997	0.002
E72.2 Disorders of urea cycle metabolism	0.000	0.997	0.002
F10.3 Withdrawal state	0.003	0.997	0.000
R54 Senility	0.003	0.997	0.000
S64 Injury of nerves at wrist and hand level	0.003	0.997	0.000
C45.2 Mesothelioma of pericardium	0.000	0.997	0.002
C45.1 Mesothelioma of peritoneum	0.000	0.997	0.002
G41.9 Status epilepticus, unspecified	0.003	0.997	0.000
S63.5 Sprain and strain of wrist	0.003	0.997	0.000
E80.1 Porphyria cutanea tarda	0.000	0.997	0.002
S05.6 Penetrating wound of eyeball without foreign body	0.003	0.997	0.000
M54.64 Pain in thoracic spine (Thoracic region)	0.003	0.997	0.000
S32.11 Fracture of sacrum (open)	0.000	0.997	0.002
E72.0 Disorders of amino-acid transport	0.000	0.997	0.002
E79.9 Disorder of purine and pyrimidine metabolism, unspecified	0.000	0.997	0.002
E79.8 Other disorders of purine and pyrimidine metabolism	0.000	0.997	0.002
E79.1 Lesch-Nyhan syndrome	0.000	0.997	0.002
K72.0 Acute and subacute hepatic failure	0.000	0.997	0.003
S63.0 Dislocation of wrist	0.003	0.997	0.000
S32.3 Fracture of ilium	0.000	0.997	0.002
E72.1 Disorders of sulphur-bearing amino-acid metabolism	0.000	0.997	0.002
M23.34 Other meniscus derangements (Lateral collateral ligament or Anterior horn of lateral meniscus)	0.000	0.997	0.003
T46.1 Calcium-channel blockers	0.002	0.998	0.000
S60-S69 Injuries to the wrist and hand	0.002	0.998	0.000
S32.21 Fracture of coccyx (open)	0.000	0.998	0.002
S32.20 Fracture of coccyx (closed)	0.000	0.998	0.002
C78.8 Secondary malignant neoplasm of other and unspecified digestive organs	0.002	0.998	0.000
S05.5 Penetrating wound of eyeball with foreign body	0.002	0.998	0.000
M89.81 Other specified disorders of bone (Shoulder region)	0.002	0.998	0.000
S62.21 Fracture of first metacarpal bone (open)	0.002	0.998	0.000
S63.4 Traumatic rupture of ligament of finger at metacarpophalangeal and interphalangeal joint(s)	0.002	0.998	0.000
E80.7 Disorder of bilirubin metabolism, unspecified	0.000	0.998	0.002
E80.5 Crigler-Najjar syndrome	0.000	0.998	0.002
E80.3 Defects of catalase and peroxydase	0.000	0.998	0.002
E80.0 Hereditary erythropoietic porphyria	0.000	0.998	0.002
S64.7 Injury of multiple nerves at wrist and hand level	0.002	0.998	0.000
S91 Open wound of ankle and foot	0.000	0.998	0.002
S62.41 Multiple fractures of metacarpal bones (open)	0.002	0.998	0.000
E74.3 Other disorders of intestinal carbohydrate absorption	0.000	0.998	0.002
S05.4 Penetrating wound of orbit with or without foreign body	0.002	0.998	0.000
S61.1 Open wound of finger(s) with damage to nail	0.002	0.998	0.000
M89.85 Other specified disorders of bone (Pelvic region and thigh)	0.002	0.998	0.000
E83.3 Disorders of phosphorus metabolism	0.000	0.998	0.002
I63.3 Cerebral infarction due to thrombosis of cerebral arteries	0.002	0.998	0.000
T46.9 Other and unspecified agents primarily affecting the cardiovascular system	0.002	0.998	0.000
C21.8 Overlapping lesion of rectum, anus and anal canal	0.002	0.998	0.000
S60.8 Other superficial injuries of wrist and hand	0.002	0.998	0.000
C21 Malignant neoplasm of anus and anal canal	0.002	0.998	0.000
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease	0.000	0.998	0.002
S05.7 Avulsion of eye	0.002	0.998	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations