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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs1048709
log Bayes Factor = 130.804
Chromosome 6   position 31,914,935  (GRCh37) Explore rs1048709 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
E10.9 Without complications
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.000 1.000
K51.9 Ulcerative colitis, unspecified
1.000 0.000 0.000
K90.0 Coeliac disease
0.000 0.000 1.000
M06.9 Rheumatoid arthritis, unspecified
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
G35 Multiple sclerosis
1.000 0.000 0.000
K51 Ulcerative colitis
1.000 0.000 0.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
E11 Non-insulin-dependent diabetes mellitus
0.000 0.000 1.000
E10.1 With ketoacidosis
0.000 0.000 1.000
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.000 1.000
E03 Other hypothyroidism
0.000 0.000 1.000
E16 Other disorders of pancreatic internal secretion
0.000 0.000 1.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
E16.2 Hypoglycaemia, unspecified
0.000 0.000 1.000
E11.9 Without complications
0.000 0.000 1.000
E83.1 Disorders of iron metabolism
0.999 0.001 0.000
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.002 0.998
E10.4 With neurological complications
0.000 0.002 0.998
E14 Unspecified diabetes mellitus
0.000 0.003 0.997
I10 Essential (primary) hypertension
0.000 0.003 0.997
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.000 0.004 0.996
G35-G37 Demyelinating diseases of the central nervous system
0.993 0.007 0.000
G37 Other demyelinating diseases of central nervous system
0.991 0.009 0.000
J45.9 Asthma, unspecified
0.000 0.011 0.989
K51.3 Ulcerative (chronic) rectosigmoiditis
0.989 0.011 0.000
K51.2 Ulcerative (chronic) proctitis
0.988 0.012 0.000
G37.9 Demyelinating disease of central nervous system, unspecified
0.987 0.013 0.000
E14.3 With ophthalmic complications
0.000 0.021 0.979
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.000 0.025 0.975
E10.5 With peripheral circulatory complications
0.000 0.026 0.974
I10-I15 Hypertensive diseases
0.000 0.029 0.971
E14.9 Without complications
0.000 0.033 0.967
E78.0 Pure hypercholesterolaemia
0.000 0.034 0.966
E11.5 With peripheral circulatory complications
0.000 0.040 0.960
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.053 0.947
I20-I25 Ischaemic heart diseases
0.000 0.060 0.940
I22 Subsequent myocardial infarction
0.000 0.069 0.931
E07 Other disorders of thyroid
0.000 0.069 0.931
K51.5 Mucosal proctocolitis
0.928 0.072 0.000
E11.2 With renal complications
0.000 0.079 0.921
E13 Other specified diabetes mellitus
0.000 0.081 0.919
K51.8 Other ulcerative colitis
0.914 0.086 0.000
I22.1 Subsequent myocardial infarction of inferior wall
0.000 0.092 0.908
I24 Other acute ischaemic heart diseases
0.000 0.096 0.904
Chapter IX Diseases of the circulatory system
0.000 0.098 0.902
I25 Chronic ischaemic heart disease
0.000 0.100 0.900
I20 Angina pectoris
0.000 0.102 0.898
M06 Other rheumatoid arthritis
0.000 0.103 0.897
K51.4 Pseudopolyposis of colon
0.887 0.113 0.000
G37.8 Other specified demyelinating diseases of central nervous system
0.887 0.113 0.000
E11.3 With ophthalmic complications
0.000 0.114 0.886
L40 Psoriasis
0.000 0.114 0.886
E10.2 With renal complications
0.000 0.115 0.885
L40.9 Psoriasis, unspecified
0.000 0.116 0.884
K51.0 Ulcerative (chronic) enterocolitis
0.881 0.119 0.000
I24.9 Acute ischaemic heart disease, unspecified
0.000 0.123 0.877
L40.5 Arthropathic psoriasis
0.000 0.130 0.870
I12 Hypertensive renal disease
0.000 0.131 0.869
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.133 0.867
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.000 0.133 0.867
I22.9 Subsequent myocardial infarction of unspecified site
0.000 0.136 0.864
M05.9 Seropositive rheumatoid arthritis, unspecified
0.000 0.137 0.863
I25.5 Ischaemic cardiomyopathy
0.000 0.137 0.863
I20.9 Angina pectoris, unspecified
0.000 0.137 0.863
E70-E90 Metabolic disorders
0.003 0.137 0.860
E07.9 Disorder of thyroid, unspecified
0.000 0.137 0.863
E13.9 Without complications
0.000 0.138 0.862
E10.0 With coma
0.000 0.139 0.861
M05 Seropositive rheumatoid arthritis
0.000 0.140 0.860
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.141 0.859
M05-M14 Inflammatory polyarthropathies
0.000 0.141 0.859
I15 Secondary hypertension
0.000 0.143 0.857
E16.1 Other hypoglycaemia
0.000 0.144 0.856
L40-L45 Papulosquamous disorders
0.000 0.145 0.855
M05.90 Seropositive rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.147 0.853
L43 Lichen planus
0.000 0.154 0.846
Z93.2 Ileostomy status
0.839 0.161 0.000
L43.9 Lichen planus, unspecified
0.000 0.164 0.836
M05.99 Seropositive rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.169 0.831
E40-E46 Malnutrition
0.000 0.172 0.828
E11.1 With ketoacidosis
0.000 0.180 0.820
I20.0 Unstable angina
0.000 0.185 0.815
E10.6 With other specified complications
0.000 0.188 0.812
M06.98 Rheumatoid arthritis, unspecified (Other)
0.000 0.194 0.806
I25.8 Other forms of chronic ischaemic heart disease
0.000 0.203 0.797
E03.8 Other specified hypothyroidism
0.000 0.205 0.794
I24.0 Coronary thrombosis not resulting in myocardial infarction
0.000 0.206 0.794
I12.9 Hypertensive renal disease without renal failure
0.000 0.219 0.781
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.233 0.767
K50-K52 Noninfective enteritis and colitis
0.763 0.235 0.002
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.237 0.763
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.762 0.238 0.000
I25.1 Atherosclerotic heart disease
0.000 0.244 0.756
E11.0 With coma
0.000 0.248 0.752
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.252 0.748
K50 Crohn's disease [regional enteritis]
0.747 0.253 0.000
E11.6 With other specified complications
0.000 0.256 0.744
E07.8 Other specified disorders of thyroid
0.000 0.259 0.741
I25.0 Atherosclerotic cardiovascular disease, so described
0.000 0.266 0.734
E14.5 With peripheral circulatory complications
0.000 0.267 0.733
E14.4 With neurological complications
0.000 0.277 0.723
K50.1 Crohn's disease of large intestine
0.721 0.279 0.000
L40.0 Psoriasis vulgaris
0.000 0.279 0.721
K50.9 Crohn's disease, unspecified
0.718 0.282 0.000
E10.8 With unspecified complications
0.000 0.283 0.717
E10.7 With multiple complications
0.000 0.283 0.717
E11.7 With multiple complications
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
I15.1 Hypertension secondary to other renal disorders
0.000 0.283 0.717
E03.5 Myxoedema coma
0.000 0.283 0.717
E03.4 Atrophy of thyroid (acquired)
0.000 0.283 0.717
E03.3 Postinfectious hypothyroidism
0.000 0.283 0.717
E03.1 Congenital hypothyroidism without goitre
0.000 0.283 0.717
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.283 0.717
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.283 0.717
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.283 0.717
E16.4 Abnormal secretion of gastrin
0.000 0.283 0.717
E16.3 Increased secretion of glucagon
0.000 0.283 0.717
E15 Nondiabetic hypoglycaemic coma
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
I25.3 Aneurysm of heart
0.000 0.284 0.716
E14.8 With unspecified complications
0.000 0.285 0.715
E14.7 With multiple complications
0.000 0.285 0.715
E14.2 Withrenal complications
0.000 0.285 0.715
E14.1 With ketoacidosis
0.000 0.285 0.715
E14.0 With coma
0.000 0.285 0.715
I15.9 Seconday hypertension, unspecified
0.000 0.286 0.714
I47 Paroxysmal tachycardia
0.000 0.288 0.712
G36 Other acute disseminated demyelination
0.712 0.288 0.000
G37.5 Concentric sclerosis [Balo]
0.710 0.289 0.000
G37.4 Subacute necrotising myelitis
0.710 0.289 0.000
G37.2 Central pontine myelinolysis
0.710 0.289 0.000
G37.1 Central demyelination of corpus callosum
0.710 0.289 0.000
G37.0 Diffuse sclerosis
0.710 0.289 0.000
L40.8 Other psoriasis
0.000 0.290 0.710
I47.2 Ventricular tachycardia
0.000 0.293 0.707
E46 Unspecified protein-energy malnutrition
0.000 0.295 0.705
I47.1 Supraventricular tachycardia
0.000 0.296 0.704
I22.0 Subsequent myocardial infarction of anterior wall
0.000 0.302 0.698
I13 Hypertensive heart and renal disease
0.000 0.304 0.696
E14.6 With other specified complications
0.000 0.307 0.693
M06.3 Rheumatoid nodule
0.000 0.307 0.693
E83 Disorders of mineral metabolism
0.653 0.313 0.033
E11.8 With unspecified complications
0.000 0.316 0.684
I23 Certain current complications following acute myocardial infarction
0.000 0.317 0.683
E78.1 Pure hyperglyceridaemia
0.000 0.319 0.681
H36.0 Diabetic retinopathy
0.000 0.319 0.681
L43.8 Other lichen planus
0.000 0.320 0.680
K51.1 Ulcerative (chronic) ileocolitis
0.678 0.322 0.000
M05.97 Seropositive rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.326 0.674
E74 Other disorders of carbohydrate metabolism
0.002 0.328 0.671
E07.1 Dyshormogenetic goitre
0.000 0.332 0.667
E07.0 Hypersecretion of calcitonin
0.000 0.332 0.667
I12.0 Hypertensive renal disease with renal failure
0.000 0.337 0.663
I47.9 Paroxysmal tachycardia, unspecified
0.000 0.340 0.660
E06 Thyroiditis
0.000 0.340 0.660
I70-I79 Diseases of arteries, arterioles and capillaries
0.000 0.340 0.660
E13.8 With unspecified complications
0.000 0.341 0.659
E13.7 With multiple complications
0.000 0.341 0.659
E13.6 With other specified complications
0.000 0.341 0.659
E13.5 With peripheral circulatory complications
0.000 0.341 0.659
E13.4 With neurological complications
0.000 0.341 0.659
E13.3 With ophthalmic complications
0.000 0.341 0.659
E13.2 With renal complications
0.000 0.341 0.659
E13.1 With ketoacidosis
0.000 0.341 0.659
E13.0 With coma
0.000 0.341 0.659
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.343 0.657
E20-E35 Disorders of other endocrine glands
0.000 0.348 0.652
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.349 0.651
E78.2 Mixed hyperlipidaemia
0.000 0.349 0.650
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.351 0.649
I25.6 Silent myocardial ischaemia
0.000 0.355 0.645
M06.8 Other specified rheumatoid arthritis
0.000 0.357 0.643
M06.2 Rheumatoid bursitis
0.000 0.357 0.643
M06.1 Adult-onset Still's disease
0.000 0.357 0.643
E78.6 Lipoprotein deficiency
0.000 0.364 0.635
L40.4 Guttate psoriasis
0.000 0.365 0.635
L40.2 Acrodermatitis continua
0.000 0.365 0.635
L40.1 Generalised pustular psoriasis
0.000 0.365 0.635
I00-I02 Acute rheumatic fever
0.000 0.371 0.629
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.000 0.375 0.625
M05.96 Seropositive rheumatoid arthritis, unspecified (Lower leg)
0.000 0.375 0.625
E78.3 Hyperchylomicronaemia
0.000 0.378 0.621
M05.98 Seropositive rheumatoid arthritis, unspecified (Other)
0.000 0.381 0.619
M05.95 Seropositive rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.381 0.619
M05.94 Seropositive rheumatoid arthritis, unspecified (Hand)
0.000 0.381 0.619
M05.93 Seropositive rheumatoid arthritis, unspecified (Forearm)
0.000 0.381 0.619
M05.92 Seropositive rheumatoid arthritis, unspecified (Upper arm)
0.000 0.381 0.619
M05.91 Seropositive rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.381 0.619
E77 Disorders of glycoprotein metabolism
0.002 0.381 0.617
E76 Disorders of glycosaminoglycan metabolism
0.002 0.381 0.617
E72 Other disorders of amino-acid metabolism
0.002 0.381 0.617
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.002 0.381 0.617
E70 Disorders of aromatic amino-acid metabolism
0.002 0.381 0.617
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.002 0.381 0.617
M05.8 Other seropositive rheumatoid arthritis
0.000 0.383 0.616
M05.3 Rheumatoid arthritis with involvement of other organs and systems
0.000 0.383 0.616
M05.2 Rheumatoid vasculitis
0.000 0.383 0.616
M05.1 Rheumatoid lung disease
0.000 0.383 0.616
M05.0 Felty's syndrome
0.000 0.383 0.616
I20.1 Angina pectoris with documented spasm
0.000 0.384 0.616
M09 Juvenile arthritis in diseases classified elsewhere
0.000 0.384 0.616
M08 Juvenile arthritis
0.000 0.384 0.616
I15.8 Other secondary hypertension
0.000 0.386 0.614
I15.2 Hypertension secondary to endocrine disorders
0.000 0.386 0.614
I15.0 Renovascular hypertension
0.000 0.386 0.614
L44 Other papulosquamous disorders
0.000 0.387 0.613
L41 Parapsoriasis
0.000 0.387 0.613
L45 Papulosquamous disorders in diseases classified elsewhere
0.000 0.387 0.613
I25.4 Coronary artery aneurysm
0.000 0.390 0.610
L43.3 Subacute (active) lichen planus
0.000 0.393 0.606
L43.2 Lichenoid drug reaction
0.000 0.393 0.606
L43.1 Bullous lichen planus
0.000 0.393 0.606
L43.0 Hypertrophic lichen planus
0.000 0.393 0.606
M06.4 Inflammatory polyarthropathy
0.000 0.394 0.606
I22.8 Subsequent myocardial infarction of other sites
0.000 0.396 0.604
E23 Hypofunction and other disorders of pituitary gland
0.000 0.396 0.604
H36 Retinal disorders in diseases classified elsewhere
0.000 0.399 0.601
I79.2 Peripheral angiopathy in diseases classified elsewhere
0.000 0.399 0.601
I24.1 Dressler's syndrome
0.000 0.401 0.599
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.406 0.594
E45 Retarded development following protein-energy malnutrition
0.000 0.406 0.594
E43 Unspecified severe protein-energy malnutrition
0.000 0.406 0.594
E42 Marasmic kwashiorkor
0.000 0.406 0.594
E41 Nutritional marasmus
0.000 0.406 0.594
E40 Kwashiorkor
0.000 0.406 0.594
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.002 0.407 0.591
E83.3 Disorders of phosphorus metabolism
0.583 0.408 0.009
L40.3 Pustulosis palmaris et plantaris
0.000 0.411 0.588
M06.34 Rheumatoid nodule (Hand)
0.000 0.415 0.585
I71 Aortic aneurysm and dissection
0.000 0.418 0.582
E80 Disorders of porphyrin and bilirubin metabolism
0.002 0.422 0.577
I30-I52 Other forms of heart disease
0.000 0.428 0.572
E84 Cystic fibrosis
0.002 0.432 0.566
E05.9 Thyrotoxicosis, unspecified
0.000 0.438 0.562
E89.3 Postprocedural hypopituitarism
0.000 0.440 0.560
M10 Gout
0.000 0.440 0.560
I47.0 Reentry ventricular arrhythmia
0.000 0.442 0.558
E83.9 Disorder of mineral metabolism, unspecified
0.538 0.442 0.019
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.000 0.443 0.556
E29 Testicular dysfunction
0.000 0.444 0.556
E79 Disorders of purine and pyrimidine metabolism
0.002 0.447 0.551
I71.9 Aortic aneurysm of unspecified site, without mention of rupture
0.000 0.448 0.552
M07 Psoriatic and enteropathic arthropathies
0.000 0.450 0.550
L42 Pityriasis rosea
0.000 0.455 0.545
H30-H36 Disorders of choroid and retina
0.000 0.457 0.543
E23.2 Diabetes insipidus
0.000 0.458 0.542
E74.3 Other disorders of intestinal carbohydrate absorption
0.001 0.464 0.535
M14 Arthropathies in other diseases classified elsewhere
0.000 0.469 0.530
I70 Atherosclerosis
0.000 0.471 0.529
E89.2 Postprocedural hypoparathyroidism
0.000 0.481 0.519
M11 Other crystal arthropathies
0.000 0.481 0.519
M06.32 Rheumatoid nodule (Upper arm)
0.000 0.483 0.517
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.486 0.514
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.486 0.514
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.486 0.514
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.486 0.514
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.486 0.514
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.486 0.514
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.486 0.514
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.486 0.514
E06.3 Autoimmune thyroiditis
0.000 0.489 0.511
E78.4 Other hyperlipidaemia
0.000 0.489 0.511
G36.9 Acute disseminated demyelination, unspecified
0.510 0.489 0.000
G36.8 Other specified acute disseminated demyelination
0.510 0.489 0.000
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.510 0.489 0.000
G36.0 Neuromyelitis optica [Devic]
0.510 0.489 0.000
E78.8 Other disorders of lipoprotein metabolism
0.000 0.493 0.506
I11 Hypertensive heart disease
0.000 0.498 0.502
M12 Other specific arthropathies
0.000 0.498 0.501
I71.0 Dissection of aorta [any part]
0.000 0.499 0.501
I51 Complications and ill-defined descriptions of heart disease
0.000 0.500 0.500
I13.9 Hypertensive heart and renal disease, unspecified
0.000 0.500 0.499
I13.2 Hypertensive heart and renal disease with both (congestive) heart failure and renal failure
0.000 0.500 0.499
I13.1 Hypertensive heart and renal disease with renal failure
0.000 0.500 0.499
I13.0 Hypertensive heart and renal disease with (congestive) heart failure
0.000 0.500 0.499
I23.8 Other current complications following acute myocardial infarction
0.000 0.501 0.499
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.501 0.499
M06.39 Rheumatoid nodule (Site unspecified)
0.000 0.503 0.497
M06.38 Rheumatoid nodule (Other)
0.000 0.503 0.497
M06.36 Rheumatoid nodule (Lower leg)
0.000 0.503 0.497
M06.35 Rheumatoid nodule (Pelvic region and thigh)
0.000 0.503 0.497
M06.33 Rheumatoid nodule (Forearm)
0.000 0.503 0.497
M06.31 Rheumatoid nodule (Shoulder region)
0.000 0.503 0.497
M06.30 Rheumatoid nodule (Multiple sites)
0.000 0.503 0.497
E23.6 Other disorders of pituitary gland
0.000 0.505 0.495
E83.8 Other disorders of mineral metabolism
0.469 0.507 0.024
E83.2 Disorders of zinc metabolism
0.469 0.507 0.024
E83.0 Disorders of copper metabolism
0.469 0.507 0.024
H34 Retinal vascular occlusions
0.000 0.508 0.492
I23.6 Thrombosis of atrium, auricular appendage and ventricle as current complications following acute myocardial infarction
0.000 0.510 0.490
I23.5 Rupture of papillary muscle as current complication following acute myocardial infarction
0.000 0.510 0.490
I23.4 Rupture of chordae tendineae as current complication following acute myocardial infarction
0.000 0.510 0.490
I23.3 Rupture of cardiac wall without haemopericardium as current complication following acute myocardial infarction
0.000 0.510 0.490
I23.2 Ventricular septal defect as current complication following acute myocardial infarction
0.000 0.510 0.490
I23.1 Atrial septal defect as current complication following acute myocardial infarction
0.000 0.510 0.490
I23.0 Haemopericardium as current complication following acute myocardial infarction
0.000 0.510 0.490
H43 Disorders of vitreous body
0.000 0.513 0.487
E29.1 Testicular hypofunction
0.000 0.513 0.487
H43.8 Other disorders of vitreous body
0.000 0.517 0.483
E73 Lactose intolerance
0.003 0.517 0.480
E74.9 Disorder of carbohydrate metabolism, unspecified
0.001 0.518 0.481
E74.8 Other specified disorders of carbohydrate metabolism
0.001 0.518 0.481
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.001 0.518 0.481
E74.2 Disorders of galactose metabolism
0.001 0.518 0.481
E74.1 Disorders of fructose metabolism
0.001 0.518 0.481
E74.0 Glycogen storage disease
0.001 0.518 0.481
H43-H45 Disorders of vitreous body and globe
0.000 0.524 0.476
E23.7 Disorder of pituitary gland, unspecified
0.000 0.524 0.476
E24 Cushing's syndrome
0.000 0.524 0.476
I51.8 Other ill-defined heart diseases
0.000 0.526 0.474
# Top node
0.000 0.527 0.473
E06.5 Other chronic thyroiditis
0.000 0.527 0.473
E06.4 Drug-induced thyroiditis
0.000 0.527 0.473
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.527 0.473
E06.1 Subacute thyroiditis
0.000 0.527 0.473
E06.0 Acute thyroiditis
0.000 0.527 0.473
Chapter VII Diseases of the eye and adnexa
0.000 0.527 0.473
E88 Other metabolic disorders
0.002 0.528 0.470
E28 Ovarian dysfunction
0.000 0.528 0.472
E05.5 Thyroid crisis or storm
0.000 0.529 0.471
E05.4 Thyrotoxicosis factitia
0.000 0.529 0.471
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.529 0.471
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.529 0.471
I46 Cardiac arrest
0.000 0.531 0.469
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.532 0.468
E32 Diseases of thymus
0.000 0.532 0.468
E31 Polyglandular dysfunction
0.000 0.532 0.468
E30 Disorders of puberty, not elsewhere classified
0.000 0.532 0.468
E25 Adrenogenital disorders
0.000 0.532 0.468
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.533 0.467
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.533 0.467
E89.5 Postprocedural testicular hypofunction
0.000 0.533 0.467
E89.1 Postprocedural hypoinsulinaemia
0.000 0.533 0.467
H35 Other retinal disorders
0.000 0.537 0.463
M06.19 Adult-onset Still's disease (Site unspecified)
0.000 0.539 0.461
M06.18 Adult-onset Still's disease (Other)
0.000 0.539 0.461
M06.17 Adult-onset Still's disease (Ankle and foot)
0.000 0.539 0.461
M06.16 Adult-onset Still's disease (Lower leg)
0.000 0.539 0.461
M06.15 Adult-onset Still's disease (Pelvic region and thigh)
0.000 0.539 0.461
M06.14 Adult-onset Still's disease (Hand)
0.000 0.539 0.461
M06.13 Adult-onset Still's disease (Forearm)
0.000 0.539 0.461
M06.12 Adult-onset Still's disease (Upper arm)
0.000 0.539 0.461
M06.11 Adult-onset Still's disease (Shoulder region)
0.000 0.539 0.461
M06.10 Adult-onset Still's disease (Multiple sites)
0.000 0.539 0.461
M06.29 Rheumatoid bursitis (Site unspecified)
0.000 0.539 0.461
M06.28 Rheumatoid bursitis (Other)
0.000 0.539 0.461
M06.27 Rheumatoid bursitis (Ankle and foot)
0.000 0.539 0.461
M06.26 Rheumatoid bursitis (Lower leg)
0.000 0.539 0.461
M06.25 Rheumatoid bursitis (Pelvic region and thigh)
0.000 0.539 0.461
M06.24 Rheumatoid bursitis (Hand)
0.000 0.539 0.461
M06.23 Rheumatoid bursitis (Forearm)
0.000 0.539 0.461
M06.22 Rheumatoid bursitis (Upper arm)
0.000 0.539 0.461
M06.21 Rheumatoid bursitis (Shoulder region)
0.000 0.539 0.461
M06.20 Rheumatoid bursitis (Multiple sites)
0.000 0.539 0.461
M06.89 Other specified rheumatoid arthritis (Site unspecified)
0.000 0.539 0.461
M06.88 Other specified rheumatoid arthritis (Other)
0.000 0.539 0.461
M06.87 Other specified rheumatoid arthritis (Ankle and foot)
0.000 0.539 0.461
M06.86 Other specified rheumatoid arthritis (Lower leg)
0.000 0.539 0.461
M06.85 Other specified rheumatoid arthritis (Pelvic region and thigh)
0.000 0.539 0.461
M06.84 Other specified rheumatoid arthritis (Hand)
0.000 0.539 0.461
M06.83 Other specified rheumatoid arthritis (Forearm)
0.000 0.539 0.461
M06.82 Other specified rheumatoid arthritis (Upper arm)
0.000 0.539 0.461
M06.81 Other specified rheumatoid arthritis (Shoulder region)
0.000 0.539 0.461
M06.80 Other specified rheumatoid arthritis (Multiple sites)
0.000 0.539 0.461
E26 Hyperaldosteronism
0.000 0.540 0.460
H43.3 Other vitreous opacities
0.000 0.548 0.452
I02 Rheumatic chorea
0.000 0.549 0.451
I01 Rheumatic fever with heart involvement
0.000 0.549 0.451
E22 Hyperfunction of pituitary gland
0.000 0.549 0.451
H34.2 Other retinal artery occlusions
0.000 0.551 0.449
I79.8 Other disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.000 0.552 0.448
I79.1 Aortitis in diseases classified elsewhere
0.000 0.552 0.448
I79.0 Aneurysm of aorta in diseases classified elsewhere
0.000 0.552 0.448
I72 Other aneurysm
0.000 0.554 0.445
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.000 0.555 0.445
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.002 0.556 0.442
E70.8 Other disorders of aromatic amino-acid metabolism
0.002 0.556 0.442
E70.3 Albinism
0.002 0.556 0.442
E70.2 Disorders of tyrosine metabolism
0.002 0.556 0.442
E70.1 Other hyperphenylalaninaemias
0.002 0.556 0.442
E70.0 Classical phenylketonuria
0.002 0.556 0.442
E71.3 Disorders of fatty-acid metabolism
0.002 0.556 0.442
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.002 0.556 0.442
E71.1 Other disorders of branched-chain amino-acid metabolism
0.002 0.556 0.442
E71.0 Maple-syrup-urine disease
0.002 0.556 0.442
E72.9 Disorder of amino-acid metabolism, unspecified
0.002 0.556 0.442
E72.8 Other specified disorders of amino-acid metabolism
0.002 0.556 0.442
E72.5 Disorders of glycine metabolism
0.002 0.556 0.442
E72.4 Disorders of ornithine metabolism
0.002 0.556 0.442
E72.3 Disorders of lysine and hydroxylysine metabolism
0.002 0.556 0.442
E72.2 Disorders of urea cycle metabolism
0.002 0.556 0.442
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.002 0.556 0.442
E72.0 Disorders of amino-acid transport
0.002 0.556 0.442
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.002 0.556 0.442
E76.8 Other disorders of glucosaminoglycan metabolism
0.002 0.556 0.442
E76.3 Mucopolysaccharidosis, unspecified
0.002 0.556 0.442
E76.2 Other mucopolysaccharidoses
0.002 0.556 0.442
E76.1 Mucopolysaccharidosis, type II
0.002 0.556 0.442
E76.0 Mucopolysaccharidosis, type I
0.002 0.556 0.442
E77.9 Disorder of glycoprotein metabolism, unspecified
0.002 0.556 0.442
E77.8 Other disorders of glycoprotein metabolism
0.002 0.556 0.442
E77.1 Defects in glycoprotein degradation
0.002 0.556 0.442
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.002 0.556 0.442
I30 Acute pericarditis
0.000 0.558 0.442
M05.09 Felty's syndrome (Site unspecified)
0.000 0.558 0.442
M05.08 Felty's syndrome (Other)
0.000 0.558 0.442
M05.07 Felty's syndrome (Ankle and foot)
0.000 0.558 0.442
M05.06 Felty's syndrome (Lower leg)
0.000 0.558 0.442
M05.05 Felty's syndrome (Pelvic region and thigh)
0.000 0.558 0.442
M05.04 Felty's syndrome (Hand)
0.000 0.558 0.442
M05.03 Felty's syndrome (Forearm)
0.000 0.558 0.442
M05.02 Felty's syndrome (Upper arm)
0.000 0.558 0.442
M05.01 Felty's syndrome (Shoulder region)
0.000 0.558 0.442
M05.00 Felty's syndrome (Multiple sites)
0.000 0.558 0.442
M05.19 Rheumatoid lung disease (Site unspecified)
0.000 0.558 0.442
M05.18 Rheumatoid lung disease (Other)
0.000 0.558 0.442
M05.17 Rheumatoid lung disease (Ankle and foot)
0.000 0.558 0.442
M05.16 Rheumatoid lung disease (Lower leg)
0.000 0.558 0.442
M05.15 Rheumatoid lung disease (Pelvic region and thigh)
0.000 0.558 0.442
M05.14 Rheumatoid lung disease (Hand)
0.000 0.558 0.442
M05.13 Rheumatoid lung disease (Forearm)
0.000 0.558 0.442
M05.12 Rheumatoid lung disease (Upper arm)
0.000 0.558 0.442
M05.11 Rheumatoid lung disease (Shoulder region)
0.000 0.558 0.442
M05.10 Rheumatoid lung disease (Multiple sites)
0.000 0.558 0.442
M05.29 Rheumatoid vasculitis (Site unspecified)
0.000 0.558 0.442
M05.28 Rheumatoid vasculitis (Other)
0.000 0.558 0.442
M05.27 Rheumatoid vasculitis (Ankle and foot)
0.000 0.558 0.442
M05.26 Rheumatoid vasculitis (Lower leg)
0.000 0.558 0.442
M05.25 Rheumatoid vasculitis (Pelvic region and thigh)
0.000 0.558 0.442
M05.24 Rheumatoid vasculitis (Hand)
0.000 0.558 0.442
M05.23 Rheumatoid vasculitis (Forearm)
0.000 0.558 0.442
M05.22 Rheumatoid vasculitis (Upper arm)
0.000 0.558 0.442
M05.21 Rheumatoid vasculitis (Shoulder region)
0.000 0.558 0.442
M05.20 Rheumatoid vasculitis (Multiple sites)
0.000 0.558 0.442
M05.39 Rheumatoid arthritis with involvement of other organs and systems (Site unspecified)
0.000 0.558 0.442
M05.38 Rheumatoid arthritis with involvement of other organs and systems (Other)
0.000 0.558 0.442
M05.37 Rheumatoid arthritis with involvement of other organs and systems (Ankle and foot)
0.000 0.558 0.442
M05.36 Rheumatoid arthritis with involvement of other organs and systems (Lower leg)
0.000 0.558 0.442
M05.35 Rheumatoid arthritis with involvement of other organs and systems (Pelvic region and thigh)
0.000 0.558 0.442
M05.34 Rheumatoid arthritis with involvement of other organs and systems (Hand)
0.000 0.558 0.442
M05.33 Rheumatoid arthritis with involvement of other organs and systems (Forearm)
0.000 0.558 0.442
M05.32 Rheumatoid arthritis with involvement of other organs and systems (Upper arm)
0.000 0.558 0.442
M05.31 Rheumatoid arthritis with involvement of other organs and systems (Shoulder region)
0.000 0.558 0.442
M05.30 Rheumatoid arthritis with involvement of other organs and systems (Multiple sites)
0.000 0.558 0.442
M05.89 Other seropositive rheumatoid arthritis (Site unspecified)
0.000 0.558 0.442
M05.88 Other seropositive rheumatoid arthritis (Other)
0.000 0.558 0.442
M05.87 Other seropositive rheumatoid arthritis (Ankle and foot)
0.000 0.558 0.442
M05.86 Other seropositive rheumatoid arthritis (Lower leg)
0.000 0.558 0.442
M05.85 Other seropositive rheumatoid arthritis (Pelvic region and thigh)
0.000 0.558 0.442
M05.84 Other seropositive rheumatoid arthritis (Hand)
0.000 0.558 0.442
M05.83 Other seropositive rheumatoid arthritis (Forearm)
0.000 0.558 0.442
M05.82 Other seropositive rheumatoid arthritis (Upper arm)
0.000 0.558 0.442
M05.81 Other seropositive rheumatoid arthritis (Shoulder region)
0.000 0.558 0.442
M05.80 Other seropositive rheumatoid arthritis (Multiple sites)
0.000 0.558 0.442
I71.2 Thoracic aortic aneurysm, without mention of rupture
0.000 0.558 0.442
M08.9 Juvenile arthritis, unspecified
0.000 0.558 0.441
M08.8 Other juvenile arthritis
0.000 0.558 0.441
M08.4 Pauciarticular juvenile arthritis
0.000 0.558 0.441
M08.3 Juvenile polyarthritis (seronegative)
0.000 0.558 0.441
M08.2 Juvenile arthritis with systemic onset
0.000 0.558 0.441
M08.1 Juvenile ankylosing spondylitis
0.000 0.558 0.441
M08.0 Juvenile rheumatoid arthritis
0.000 0.558 0.441
M09.8 Juvenile arthritis in other diseases classified elsewhere
0.000 0.558 0.441
M09.2 Juvenile arthritis in ulcerative colitis
0.000 0.558 0.441
M09.1 Juvenile arthritis in Crohn's disease [regional enteritis]
0.000 0.558 0.441
M09.0 Juvenile arthritis in psoriasis
0.000 0.558 0.441
Chapter XII Diseases of the skin and subcutaneous tissue
0.000 0.558 0.441
I70.0 Atherosclerosis of aorta
0.000 0.559 0.441
L41.9 Parapsoriasis, unspecified
0.000 0.560 0.440
L41.8 Other parapsoriasis
0.000 0.560 0.440
L41.5 Retiform parapsoriasis
0.000 0.560 0.440
L41.4 Large plaque parapsoriasis
0.000 0.560 0.440
L41.3 Small plaque parapsoriasis
0.000 0.560 0.440
L41.2 Lymphomatoid papulosis
0.000 0.560 0.440
L41.1 Pityriasis lichenoides chronica
0.000 0.560 0.440
L41.0 Pityriasis lichenoides et varioliformis acuta
0.000 0.560 0.440
L44.9 Papulosquamous disorder, unspecified
0.000 0.560 0.440
L44.8 Other specified papulosquamous disorders
0.000 0.560 0.440
L44.4 Infantile papular acrodermatitis [Giannotti-Crosti]
0.000 0.560 0.440
L44.3 Lichen ruber moniliformis
0.000 0.560 0.440
L44.2 Lichen striatus
0.000 0.560 0.440
L44.1 Lichen nitidus
0.000 0.560 0.440
L44.0 Pityriasis rubra pilaris
0.000 0.560 0.440

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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