TreeWAS – Variant ID: rs10498529

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability
M75 Shoulder lesions	1.000	0.000
M70-M79 Other soft tissue disorders	1.000	0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue	1.000	0.000
E14 Unspecified diabetes mellitus	0.999	0.001
E10-E14 Diabetes mellitus	0.999	0.001
M20-M25 Other joint disorders	0.998	0.002
M75.1 Rotator cuff syndrome	0.998	0.002
E11 Non-insulin-dependent diabetes mellitus	0.997	0.003
E14.9 Without complications	0.996	0.004
M65-M68 Disorders of synovium and tendon	0.995	0.005
M65 Synovitis and tenosynovitis	0.992	0.008
M23 Internal derangement of knee	0.984	0.016
E14.3 With ophthalmic complications	0.979	0.021
M75.0 Adhesive capsulitis of shoulder	0.977	0.023
E11.3 With ophthalmic complications	0.975	0.025
M22 Disorders of patella	0.972	0.028
M65.9 Synovitis and tenosynovitis, unspecified	0.971	0.029
M23.3 Other meniscus derangements	0.969	0.031
M23.36 Other meniscus derangements (Other and unspecified lateral meniscus)	0.958	0.042
E10 Insulin-dependent diabetes mellitus	0.955	0.045
M65.8 Other synovitis and tenosynovitis	0.952	0.048
M24 Other specific joint derangements	0.952	0.048
M00-M03 Infectious arthropathies	0.950	0.050
M65.96 Synovitis and tenosynovitis, unspecified (Lower leg)	0.944	0.056
M23.33 Other meniscus derangements (Medial collateral ligament or Other and unspecified medial meniscus)	0.936	0.064
E11.9 Without complications	0.927	0.073
M31 Other necrotising vasculopathies	0.917	0.083
M77 Other enthesopathies	0.917	0.083
E11.2 With renal complications	0.916	0.084
M00 Pyogenic arthritis	0.914	0.086
M22.8 Other disorders of patella	0.914	0.086
M75.3 Calcific tendinitis of shoulder	0.914	0.086
M24.0 Loose body in joint	0.912	0.088
H30-H36 Disorders of choroid and retina	0.911	0.089
H35 Other retinal disorders	0.907	0.093
M65.84 Other synovitis and tenosynovitis (Hand)	0.906	0.094
H36 Retinal disorders in diseases classified elsewhere	0.901	0.099
E10.9 Without complications	0.897	0.103
H36.0 Diabetic retinopathy	0.895	0.105
M65.4 Radial styloid tenosynovitis [de Quervain]	0.893	0.107
M70 Soft tissue disorders related to use, overuse and pressure	0.884	0.116
M24.07 Loose body in joint (Ankle and foot)	0.882	0.118
M00.9 Pyogenic arthritis, unspecified	0.882	0.118
H35.3 Degeneration of macula and posterior pole	0.878	0.122
M23.1 Discoid meniscus (congenital)	0.857	0.143
H35.8 Other specified retinal disorders	0.852	0.148
E14.6 With other specified complications	0.851	0.149
H33 Retinal detachments and breaks	0.851	0.149
E10.6 With other specified complications	0.849	0.151
M60-M63 Disorders of muscles	0.839	0.161
E11.5 With peripheral circulatory complications	0.838	0.162
M70.6 Trochanteric bursitis	0.837	0.163
M77.1 Lateral epicondylitis	0.833	0.167
M75.9 Shoulder lesion, unspecified	0.829	0.171
M23.5 Chronic instability of knee	0.828	0.172
E11.6 With other specified complications	0.825	0.175
M31.3 Wegener's granulomatosis	0.816	0.184
M00.91 Pyogenic arthritis, unspecified (Shoulder region)	0.815	0.185
H35.2 Other proliferative retinopathy	0.808	0.192
M32 Systemic lupus erythematosus	0.808	0.192
M65.93 Synovitis and tenosynovitis, unspecified (Forearm)	0.808	0.192
E10.2 With renal complications	0.807	0.193
E11.4 With neurological complications	0.807	0.193
H31 Other disorders of choroid	0.805	0.195
M70.65 Trochanteric bursitis-Pelvic/Thigh	0.804	0.196
M86-M90 Other osteopathies	0.803	0.197
M00.96 Pyogenic arthritis, unspecified (Lower leg)	0.803	0.197
M22.4 Chondromalacia patellae	0.803	0.197
M23.8 Other internal derangements of knee	0.801	0.199
M65.92 Synovitis and tenosynovitis, unspecified (Upper arm)	0.795	0.205
M65.86 Other synovitis and tenosynovitis (Lower leg)	0.794	0.206
M75.2 Bicipital tendinitis	0.793	0.207
Chapter IV Endocrine, nutritional and metabolic diseases	0.789	0.211
M23.31 Other meniscus derangements (Anterior cruciate ligament or Anterior horn of medial meniscus)	0.785	0.215
H33.2 Serous retinal detachment	0.784	0.216
M22.3 Other derangements of patella	0.784	0.216
M24.4 Recurrent dislocation and subluxation of joint	0.774	0.226
M65.44 Radial styloid tenosynovitis [de Quervain] (Hand)	0.774	0.226
M77.12 Lateral epicondylitis (Upper arm)	0.772	0.228
M34 Systemic sclerosis	0.772	0.228
M31.5 Giant cell arteritis with polymyalgia rheumatica	0.772	0.228
M65.91 Synovitis and tenosynovitis, unspecified (Shoulder region)	0.770	0.230
M72 Fibroblastic disorders	0.769	0.231
H33.4 Traction detachment of retina	0.768	0.232
M23.16 Discoid meniscus (congenital) (Other and unspecified lateral meniscus)	0.765	0.235
Chapter VII Diseases of the eye and adnexa	0.764	0.236
M40-M43 Deforming dorsopathies	0.760	0.240
M65.90 Synovitis and tenosynovitis, unspecified (Multiple sites)	0.757	0.243
# Top node	0.755	0.245
M22.2 Patellofemoral disorders	0.754	0.246
E20-E35 Disorders of other endocrine glands	0.754	0.246
M21 Other acquired deformities of limbs	0.751	0.249
M60 Myositis	0.750	0.250
E14.2 Withrenal complications	0.750	0.250
M36 Systemic disorders of connective tissue in diseases classified elsewhere	0.750	0.250
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities	0.747	0.253
M24.8 Other specific joint derangements, not elsewhere classified	0.746	0.254
M65.43 Radial styloid tenosynovitis [de Quervain] (Forearm)	0.740	0.260
M77.4 Metatarsalgia	0.738	0.262
M23.0 Cystic meniscus	0.735	0.265
H31.0 Chorioretinal scars	0.735	0.265
M65.99 Synovitis and tenosynovitis, unspecified (Site unspecified)	0.734	0.266
E11.0 With coma	0.732	0.268
H35.7 Separation of retinal layers	0.729	0.271
E14.4 With neurological complications	0.728	0.272
E10.3 With ophthalmic complications	0.727	0.273
Q80-Q89 Other congenital malformations	0.720	0.280
E14.8 With unspecified complications	0.719	0.281
M75.8 Other shoulder lesions	0.717	0.283
M73 Soft tissue disorders in diseases classified elsewhere	0.717	0.283
H15-H22 Disorders of sclera, cornea, iris and ciliary body	0.717	0.283
E14.7 With multiple complications	0.716	0.284
E14.5 With peripheral circulatory complications	0.716	0.284
E14.1 With ketoacidosis	0.716	0.284
E14.0 With coma	0.716	0.284
E12 Malnutrition-related diabetes mellitus	0.716	0.284
E11.7 With multiple complications	0.715	0.285
H33.5 Other retinal detachments	0.715	0.285
M23.4 Loose body in knee	0.714	0.286
M68 Disorders of synovium and tendon in diseases classified elsewhere	0.713	0.287
M65.2 Calcific tendinitis	0.711	0.289
M65.0 Abscess of tendon sheath	0.711	0.289
E10.8 With unspecified complications	0.708	0.292
M77.0 Medial epicondylitis	0.707	0.293
M00.0 Staphylococcal arthritis and polyarthritis	0.704	0.296
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system	0.703	0.297
M91-M94 Chondropathies	0.701	0.299
H35.4 Peripheral retinal degeneration	0.700	0.300
M86 Osteomyelitis	0.700	0.300
M23.6 Other spontaneous disruption of ligament(s) of knee	0.697	0.303
E21 Hyperparathyroidism and other disorders of parathyroid gland	0.697	0.303
M22.1 Recurrent subluxation of patella	0.697	0.303
M22.9 Disorder of patella, unspecified	0.697	0.303
M22.0 Recurrent dislocation of patella	0.697	0.303
M65.98 Synovitis and tenosynovitis, unspecified (Other)	0.696	0.304
M24.6 Ankylosis of joint	0.695	0.305
M23.37 Other meniscus derangements-Capsular lig	0.695	0.305
M66 Spontaneous rupture of synovium and tendon	0.694	0.306
M23.83 Other internal derangements of knee (Medial collateral ligament or Other and unspecified medial meniscus)	0.693	0.307
M23.34 Other meniscus derangements (Lateral collateral ligament or Anterior horn of lateral meniscus)	0.690	0.309
M67 Other disorders of synovium and tendon	0.689	0.311
M02 Reactive arthropathies	0.689	0.311
M24.3 Pathological dislocation and subluxation of joint, not elsewhere classified	0.689	0.311
M65.87 Other synovitis and tenosynovitis (Ankle and foot)	0.688	0.312
E10.7 With multiple complications	0.685	0.315
M23.59 Chronic instability of knee (Unspecified ligament or Unspecified meniscus)	0.684	0.316
M65.89 Other synovitis and tenosynovitis (Site unspecified)	0.683	0.317
M65.88 Other synovitis and tenosynovitis (Other)	0.683	0.317
M65.85 Other synovitis and tenosynovitis (Pelvic region and thigh)	0.683	0.317
M65.82 Other synovitis and tenosynovitis (Upper arm)	0.683	0.317
M65.81 Other synovitis and tenosynovitis (Shoulder region)	0.683	0.317
M65.80 Other synovitis and tenosynovitis (Multiple sites)	0.683	0.317
M24.9 Joint derangement, unspecified	0.683	0.317
M24.7 Protrusio acetabuli	0.683	0.317
M03 Postinfective and reactive arthropathies in diseases classified elsewhere	0.681	0.319
M01 Direct infections of joint in infectious and parasitic diseases classified elsewhere	0.681	0.319
M31.1 Thrombotic microangiopathy	0.681	0.319
M24.01 Loose body in joint (Shoulder region)	0.675	0.325
M32.1 Systemic lupus erythematosus with organ or system involvement	0.671	0.329
E10.5 With peripheral circulatory complications	0.668	0.332
M77.9 Enthesopathy, unspecified	0.666	0.334
E10.4 With neurological complications	0.663	0.336
M24.41 Recurrent dislocation and subluxation of joint (Shoulder region)	0.663	0.337
M65.83 Other synovitis and tenosynovitis (Forearm)	0.660	0.340
Chapter XX External causes of morbidity and mortality	0.659	0.341
H46-H48 Disorders of optic nerve and visual pathways	0.659	0.341
M31.9 Necrotising vasculopathy, unspecified	0.657	0.343
M31.8 Other specified necrotising vasculopathies	0.657	0.343
M31.7 Microscopic polyangiitis	0.657	0.343
M31.4 Aortic arch syndrome [Takayasu]	0.657	0.343
M31.2 Lethal midline granuloma	0.657	0.343
M31.0 Hypersensitivity angiitis	0.657	0.343
M77.8 Other enthesopathies, not elsewhere classified	0.657	0.343
M77.3 Calcaneal spur	0.657	0.343
M77.2 Periarthritis of wrist	0.657	0.343
Q67 Congenital musculoskeletal deformities of head, face, spine and chest	0.657	0.343
M00.8 Arthritis and polyarthritis due to other specified bacterial agents	0.655	0.345
M00.2 Other streptococcal arthritis and polyarthritis	0.655	0.345
M00.1 Pneumococcal arthritis and polyarthritis	0.655	0.345
M24.09 Loose body in joint (Site unspecified)	0.654	0.346
M24.08 Loose body in joint (Other)	0.654	0.346
M24.06 Loose body in joint-Lower leg	0.654	0.346
M24.05 Loose body in joint (Pelvic region and thigh)	0.654	0.346
M24.04 Loose body in joint (Hand)	0.654	0.346
M24.03 Loose body in joint (Forearm)	0.654	0.346
M24.00 Loose body in joint (Multiple sites)	0.654	0.346
H32 Chorioretinal disorders in diseases classified elsewhere	0.653	0.347
M23.82 Other internal derangements of knee (Posterior cruciate ligament or Posterior horn of medial meniscus)	0.652	0.347
H35.1 Retinopathy of prematurity	0.650	0.350
H18 Other disorders of cornea	0.650	0.350
M24.1 Other articular cartilage disorders	0.648	0.352
H36.8 Other retinal disorders in diseases classified elsewhere	0.646	0.354
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use	0.646	0.354
M23.51 Chronic instability of knee (Anterior cruciate ligament or Anterior horn of medial meniscus)	0.646	0.354
M70.7 Other bursitis of hip	0.646	0.354
M76 Enthesopathies of lower limb, excluding foot	0.645	0.354
M24.5 Contracture of joint	0.645	0.355
M24.02 Loose body in joint (Upper arm)	0.642	0.358
M60.9 Myositis, unspecified	0.642	0.358
M65.49 Radial styloid tenosynovitis [de Quervain]-Site unspec	0.640	0.360
M65.48 Radial styloid tenosynovitis [de Quervain]-Other	0.640	0.360
M65.47 Radial styloid tenosynovitis [de Quervain]-Ankle/foot	0.640	0.360
M65.46 Radial styloid tenosynovitis [de Quervain]-Lower leg	0.640	0.360
M65.45 Radial styloid tenosynovitis [de Quervain]-Pelvic/thigh	0.640	0.360
M65.42 Radial styloid tenosynovitis [de Quervain]-Upper arm	0.640	0.360
M65.41 Radial styloid tenosynovitis [de Quervain]-Shldr region	0.640	0.360
M65.40 Radial styloid tenosynovitis [de Quervain] (Multiple sites)	0.640	0.360
H30 Chorioretinal inflammation	0.639	0.361
E21.3 Hyperparathyroidism, unspecified	0.637	0.363
M86.9 Osteomyelitis, unspecified	0.636	0.364
M05-M14 Inflammatory polyarthropathies	0.635	0.365
M70.9 Unspecified soft tissue disorder related to use, overuse and pressure	0.634	0.366
M70.8 Other soft tissue disorders related to use, overuse and pressure	0.634	0.366
M70.3 Other bursitis of elbow	0.634	0.366
M70.1 Bursitis of hand	0.634	0.366
M70.0 Chronic crepitant synovitis of hand and wrist	0.634	0.366
E22 Hyperfunction of pituitary gland	0.633	0.367
M00.99 Pyogenic arthritis, unspecified (Site unspecified)	0.632	0.367
M00.98 Pyogenic arthritis, unspecified (Other)	0.632	0.367
M00.95 Pyogenic arthritis, unspecified (Pelvic region and thigh)	0.632	0.367
M00.94 Pyogenic arthritis, unspecified (Hand)	0.632	0.367
M00.93 Pyogenic arthritis, unspecified (Forearm)	0.632	0.367
M00.92 Pyogenic arthritis, unspecified (Upper arm)	0.632	0.367
M00.90 Pyogenic arthritis, unspecified (Multiple sites)	0.632	0.367
M87 Osteonecrosis	0.632	0.368
Chapter II Neoplasms	0.632	0.368
H21 Other disorders of iris and ciliary body	0.631	0.369
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx	0.629	0.371
E20 Hypoparathyroidism	0.628	0.372
E10.0 With coma	0.627	0.373
M65.94 Synovitis and tenosynovitis, unspecified (Hand)	0.627	0.373
H35.5 Hereditary retinal dystrophy	0.626	0.374
M60.0 Infective myositis	0.626	0.374
Y45 Analgesics, antipyretics and anti-inflammatory drugs	0.626	0.374
E27 Other disorders of adrenal gland	0.625	0.375
H10-H13 Disorders of conjunctiva	0.625	0.375
Q83 Congenital malformations of breast	0.621	0.379
M65.1 Other infective (teno)synovitis	0.619	0.381
M31.6 Other giant cell arteritis	0.619	0.381
M70.5 Other bursitis of knee	0.616	0.383
Q85 Phakomatoses, not elsewhere classified	0.617	0.383
M40 Kyphosis and lordosis	0.616	0.384
M33 Dermatopolymyositis	0.615	0.384
Q67.5 Congenital deformity of spine	0.615	0.385
M65.95 Synovitis and tenosynovitis, unspecified (Pelvic region and thigh)	0.615	0.385
M23.19 Discoid meniscus (congenital) (Unspecified ligament or Unspecified meniscus)	0.614	0.386
M23.17 Discoid meniscus (congenital)-Capsular lig	0.614	0.386
M23.15 Discoid meniscus (congenital) (Posterior horn of lateral meniscus)	0.614	0.386
M23.14 Discoid meniscus (congenital) (Lateral collateral ligament or Anterior horn of lateral meniscus)	0.614	0.386
M23.13 Discoid meniscus (congenital) (Medial collateral ligament or Other and unspecified medial meniscus)	0.614	0.386
M23.12 Discoid meniscus (congenital) (Posterior cruciate ligament or Posterior horn of medial meniscus)	0.614	0.386
M23.11 Discoid meniscus (congenital) (Anterior cruciate ligament or Anterior horn of medial meniscus)	0.614	0.386
M23.10 Discoid meniscus (congenital) (Multiple sites)	0.614	0.386
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion	0.614	0.386
M00.97 Pyogenic arthritis, unspecified (Ankle and foot)	0.613	0.386
Y45.1 Salicylates	0.613	0.387
M23.86 Other internal derangements of knee (Other and unspecified lateral meniscus)	0.612	0.388
M21.3 Wrist or foot drop (acquired)	0.612	0.388
M23.9 Internal derangement of knee, unspecified	0.611	0.389
M90 Osteopathies in diseases classified elsewhere	0.611	0.389
M77.47 Metatarsalgia-Ankle/Foot	0.610	0.390
M34.9 Systemic sclerosis, unspecified	0.610	0.390
E11.8 With unspecified complications	0.609	0.391
Q89 Other congenital malformations, not elsewhere classified	0.609	0.391
Q90-Q99 Chromosomal abnormalities, not elsewhere classified	0.606	0.394
C30-C39 Malignant neoplasms of respiratory and intrathoracic organs	0.603	0.397
H34 Retinal vascular occlusions	0.603	0.397
M63 Disorders of muscle in diseases classified elsewhere	0.602	0.398
M61 Calcification and ossification of muscle	0.602	0.398
M30 Polyarteritis nodosa and related conditions	0.601	0.399
M70.69 Trochanteric bursitis-Site unspec	0.600	0.400
M70.68 Trochanteric bursitis-Other	0.600	0.400
M70.67 Trochanteric bursitis-Ankle/Foot	0.600	0.400
M70.66 Trochanteric bursitis-Lower Leg	0.600	0.400
M70.64 Trochanteric bursitis-Hand	0.600	0.400
M70.63 Trochanteric bursitis-Forearm	0.600	0.400
M70.62 Trochanteric bursitis-Upper arm	0.600	0.400
M70.61 Trochanteric bursitis-Shldr region	0.600	0.400
M70.60 Trochanteric bursitis-Mult sites	0.600	0.400
C76-C80 Malignant neoplasms of ill-defined, secondary and unspecified sites	0.599	0.401
M24.86 Other specific joint derangements, not elsewhere classified (Lower leg)	0.598	0.402
M72.0 Palmar fascial fibromatosis [Dupuytren]	0.598	0.402
M77.19 Lateral epicondylitis (Site unspecified)	0.597	0.403
M77.18 Lateral epicondylitis-Other	0.597	0.403
M77.17 Lateral epicondylitis-Ankle/Foot	0.597	0.403
M77.16 Lateral epicondylitis (Lower leg)	0.597	0.403
M77.15 Lateral epicondylitis (Pelvic region and thigh)	0.597	0.403
M77.14 Lateral epicondylitis-Hand	0.597	0.403
M77.13 Lateral epicondylitis-Forearm	0.597	0.403
M77.11 Lateral epicondylitis-Shldr region	0.597	0.403
M77.10 Lateral epicondylitis (Multiple sites)	0.597	0.403
M65.3 Trigger finger	0.597	0.403
E13 Other specified diabetes mellitus	0.596	0.404
H21.5 Other adhesions and disruptions of iris and ciliary body	0.596	0.404
M23.57 Chronic instability of knee (Capsular ligament)	0.594	0.406
M23.56 Chronic instability of knee (Other and unspecified lateral meniscus)	0.594	0.406
M23.55 Chronic instability of knee (Posterior horn of lateral meniscus)	0.594	0.406
M23.54 Chronic instability of knee (Lateral collateral ligament or Anterior horn of lateral meniscus)	0.594	0.406
M23.53 Chronic instability of knee (Medial collateral ligament or Other and unspecified medial meniscus)	0.594	0.406
M23.52 Chronic instability of knee (Posterior cruciate ligament or Posterior horn of medial meniscus)	0.594	0.406
M23.50 Chronic instability of knee (Multiple sites)	0.594	0.406
H46 Optic neuritis	0.593	0.407
Q66 Congenital deformities of feet	0.592	0.408
M24.83 Other specific joint derangements, not elsewhere classified (Forearm)	0.592	0.408
M41 Scoliosis	0.592	0.408
Q00-Q07 Congenital malformations of the nervous system	0.591	0.409
H31.1 Choroidal degeneration	0.590	0.409
E22.0 Acromegaly and pituitary gigantism	0.590	0.410
M23.04 Cystic meniscus (Lateral collateral ligament or Anterior horn of lateral meniscus)	0.589	0.411
C02 Malignant neoplasm of other and unspecified parts of tongue	0.588	0.412
C34 Malignant neoplasm of bronchus and lung	0.585	0.415
M23.80 Other internal derangements of knee (Multiple sites)	0.584	0.415
M24.2 Disorder of ligament	0.584	0.416
M21.1 Varus deformity, not elsewhere classified	0.582	0.418
M21.6 Other acquired deformities of ankle and foot	0.581	0.419
M32.9 Systemic lupus erythematosus, unspecified	0.579	0.421
M32.8 Other forms of systemic lupus erythematosus	0.579	0.421
M32.0 Drug-induced systemic lupus erythematosus	0.579	0.421
H31.9 Disorder of choroid, unspecified	0.577	0.423
H31.4 Choroidal detachment	0.577	0.423
H31.3 Choroidal haemorrhage and rupture	0.577	0.423
H31.2 Hereditary choroidal dystrophy	0.577	0.423
M07 Psoriatic and enteropathic arthropathies	0.576	0.424
M77.5 Other enthesopathy of foot	0.575	0.425
M23.87 Other internal derangements of knee (Capsular ligament)	0.574	0.425
M23.85 Other internal derangements of knee (Posterior horn of lateral meniscus)	0.574	0.425
M23.84 Other internal derangements of knee (Lateral collateral ligament or Anterior horn of lateral meniscus)	0.574	0.425
H35.0 Background retinopathy and retinal vascular changes	0.573	0.427
H35.9 Retinal disorder, unspecified	0.572	0.428
M36.8 Systemic disorders of connective tissue in other diseases classified elsewhere	0.571	0.429
M35 Other systemic involvement of connective tissue	0.570	0.430
Q87 Other specified congenital malformation syndromes affecting multiple systems	0.568	0.432
M34.8 Other forms of systemic sclerosis	0.567	0.433
C04 Malignant neoplasm of floor of mouth	0.567	0.433
Q10-Q18 Congenital malformations of eye, ear, face and neck	0.565	0.435
Y46 Antiepileptics and anti-Parkinsonism drugs	0.565	0.435
Q38-Q45 Other congenital malformations of the digestive system	0.564	0.436
E28 Ovarian dysfunction	0.564	0.436
M93 Other osteochondropathies	0.563	0.437
M21.7 Unequal limb length (acquired)	0.563	0.437
E40-E46 Malnutrition	0.561	0.439
H33.1 Retinoschisis and retinal cysts	0.561	0.439
M70.2 Olecranon bursitis	0.559	0.441
M23.03 Cystic meniscus (Medial collateral ligament or Other and unspecified medial meniscus)	0.558	0.442
M95-M99 Other disorders of the musculoskeletal system and connective tissue	0.558	0.442
C78 Secondary malignant neoplasm of respiratory and digestive organs	0.558	0.442
M72.2 Plantar fascial fibromatosis	0.558	0.442
M77.02 Medial epicondylitis (Upper arm)	0.556	0.443
M24.49 Recurrent dislocation and subluxation of joint (Site unspecified)	0.555	0.445
M24.48 Recurrent dislocation and subluxation of joint (Other)	0.555	0.445
M24.46 Recurrent dislocation and subluxation of joint (Lower leg)	0.555	0.445
M24.43 Recurrent dislocation and subluxation of joint (Forearm)	0.555	0.445
M24.42 Recurrent dislocation and subluxation of joint (Upper arm)	0.555	0.445
M24.40 Recurrent dislocation and subluxation of joint (Multiple sites)	0.555	0.445
H19 Disorders of sclera and cornea in diseases classified elsewhere	0.555	0.445
M00.06 Staphylococcal arthritis and polyarthritis (Lower leg)	0.554	0.446
M34.2 Systemic sclerosis induced by drugs and chemicals	0.554	0.446
M34.0 Progressive systemic sclerosis	0.554	0.446
M24.45 Recurrent dislocation and subluxation of joint (Pelvic region and thigh)	0.552	0.448
M72.9 Fibroblastic disorder, unspecified	0.551	0.449
M72.8 Other fibroblastic disorders	0.551	0.449
M72.6 Necrotizing fasciitis	0.551	0.449
M72.5 Fasciitis, not elsewhere classified	0.551	0.449
M72.4 Pseudosarcomatous fibromatosis	0.551	0.449
M72.3 Nodular fasciitis	0.551	0.449
M72.1 Knuckle pads	0.551	0.449
M23.81 Other internal derangements of knee (Anterior cruciate ligament or Anterior horn of medial meniscus)	0.550	0.450
M24.81 Other specific joint derangements, not elsewhere classified (Shoulder region)	0.550	0.450
M67.4 Ganglion	0.550	0.450
M24.47 Recurrent dislocation and subluxation of joint (Ankle and foot)	0.550	0.450
H43-H45 Disorders of vitreous body and globe	0.549	0.451
H18.9 Disorder of cornea, unspecified	0.548	0.452
C79 Secondary malignant neoplasm of other sites	0.548	0.452
M70.4 Prepatellar bursitis	0.547	0.452
X58-X59 Accidental exposure to other and unspecified factors	0.547	0.453
V80-V89 Other land transport accidents	0.547	0.453
Y48 Anaesthetics and therapeutic gases	0.547	0.453
Y43 Primarily systemic agents	0.547	0.453
M77.94 Enthesopathy, unspecified (Hand)	0.546	0.454
H31.8 Other specified disorders of choroid	0.545	0.454
M42 Spinal osteochondrosis	0.545	0.455
C78.1 Secondary malignant neoplasm of mediastinum	0.544	0.456
E27.4 Other and unspecified adrenocortical insufficiency	0.543	0.457
Q76 Congenital malformations of spine and bony thorax	0.543	0.457
M60.95 Myositis, unspecified (Pelvic region and thigh)	0.543	0.457
M41.8 Other forms of scoliosis	0.542	0.458
H35.6 Retinal haemorrhage	0.542	0.458
M23.49 Loose body in knee-Unspec lig/men	0.542	0.458
H18.1 Bullous keratopathy	0.541	0.458
E21.0 Primary hyperparathyroidism	0.541	0.459
Chapter XVI Certain conditions originating in the perinatal period	0.541	0.459
E35 Disorders of endocrine glands in diseases classified elsewhere	0.541	0.459
E32 Diseases of thymus	0.541	0.459
E31 Polyglandular dysfunction	0.541	0.459
E30 Disorders of puberty, not elsewhere classified	0.541	0.459
E25 Adrenogenital disorders	0.541	0.459
M71 Other bursopathies	0.540	0.459
M34.1 CR(E)ST syndrome	0.540	0.460
M21.9 Acquired deformity of limb, unspecified	0.539	0.461
M21.8 Other specified acquired deformities of limbs	0.539	0.461
M60.8 Other myositis	0.538	0.462
M60.2 Foreign body granuloma of soft tissue, not elsewhere classified	0.538	0.462
M60.1 Interstitial myositis	0.538	0.462
H18.6 Keratoconus	0.538	0.462
M36.4 Arthropathy in hypersensitivity reactions classified elsewhere	0.537	0.462
M36.3 Arthropathy in other blood disorders	0.537	0.462
M36.2 Haemophilic arthropathy	0.537	0.462
M36.1 Arthropathy in neoplastic disease	0.537	0.462
M36.0 Dermato(poly)myositis in neoplastic disease	0.537	0.462
M86.94 Osteomyelitis, unspecified (Hand)	0.537	0.463
E20.9 Hypoparathyroidism, unspecified	0.537	0.463
Y56 Topical agents primarily affecting skin and mucous membrane and ophthalmological, otorhinolaryngological and dental drugs	0.536	0.463
Q35-Q37 Cleft lip and cleft palate	0.536	0.464
Q30-Q34 Congenital malformations of the respiratory system	0.536	0.464
M24.89 Other specific joint derangements, not elsewhere classified (Site unspecified)	0.535	0.465
M24.88 Other specific joint derangements, not elsewhere classified (Other)	0.535	0.465
M24.82 Other specific joint derangements, not elsewhere classified (Upper arm)	0.535	0.465
M24.80 Other specific joint derangements, not elsewhere classified (Multiple sites)	0.535	0.465
M07.3 Other psoriatic arthropathies	0.535	0.465
M24.44 Recurrent dislocation and subluxation of joint (Hand)	0.534	0.466
M62 Other disorders of muscle	0.533	0.467
Q82 Other congenital malformations of skin	0.532	0.468
H11 Other disorders of conjunctiva	0.532	0.468
M23.39 Other meniscus derangements (Unspecified ligament or Unspecified meniscus)	0.532	0.468
C45-C49 Malignant neoplasms of mesothelial and soft tissue	0.531	0.469
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue	0.530	0.470
M67.0 Short Achilles tendon (acquired)	0.530	0.470
E26 Hyperaldosteronism	0.530	0.470
Q74 Other congenital malformations of limb(s)	0.530	0.470
M77.49 Metatarsalgia-Site unspec	0.529	0.471
M77.48 Metatarsalgia-Other	0.529	0.471
M77.46 Metatarsalgia-Lower Leg	0.529	0.471
M77.45 Metatarsalgia-Pelvic/Thigh	0.529	0.471
M77.44 Metatarsalgia-Hand	0.529	0.471
M77.43 Metatarsalgia-Forearm	0.529	0.471
M77.42 Metatarsalgia-Upper arm	0.529	0.471
M77.41 Metatarsalgia-Shldr region	0.529	0.471
M77.40 Metatarsalgia-Mult sites	0.529	0.471
Q89.2 Congenital malformations of other endocrine glands	0.529	0.471
M23.46 Loose body in knee-O/unsp lat men	0.529	0.471
M23.09 Cystic meniscus (Unspecified ligament or Unspecified meniscus)	0.527	0.473
M23.07 Cystic meniscus-Capsular lig	0.527	0.473
M23.05 Cystic meniscus (Posterior horn of lateral meniscus)	0.527	0.473
M23.02 Cystic meniscus (Posterior cruciate ligament or Posterior horn of medial meniscus)	0.527	0.473
M23.01 Cystic meniscus (Anterior cruciate ligament or Anterior horn of medial meniscus)	0.527	0.473
M23.00 Cystic meniscus (Multiple sites)	0.527	0.473
M23.35 Other meniscus derangements (Posterior horn of lateral meniscus)	0.526	0.473
E21.1 Secondary hyperparathyroidism, not elsewhere classified	0.526	0.474
Y43.1 Antineoplastic antimetabolites	0.525	0.475
M24.17 Other articular cartilage disorders (Ankle and foot)	0.524	0.476
W20-W49 Exposure to inanimate mechanical forces	0.524	0.476
Q83.8 Other congenital malformations of breast	0.523	0.477
M21.5 Acquired clawhand, clubhand, clawfoot and clubfoot	0.523	0.477
E24 Cushing's syndrome	0.523	0.477
M24.85 Other specific joint derangements, not elsewhere classified (Pelvic region and thigh)	0.521	0.479
H15 Disorders of sclera	0.519	0.480
Y53 Agents primarily affecting the gastro-intestinal system	0.518	0.482
M24.84 Other specific joint derangements, not elsewhere classified (Hand)	0.518	0.482
C50-C50 Malignant neoplasm of breast	0.518	0.482
C07 Malignant neoplasm of parotid gland	0.517	0.483
E27.1 Primary adrenocortical insufficiency	0.517	0.483
Q86 Congenital malformation syndromes due to known exogenous causes, not elsewhere classified	0.517	0.483
Q84 Other congenital malformations of integument	0.517	0.483
Q81 Epidermolysis bullosa	0.517	0.483
Q80 Congenital ichthyosis	0.517	0.483
C34.9 Bronchus or lung, unspecified	0.516	0.484
Q20-Q28 Congenital malformations of the circulatory system	0.515	0.485
H18.0 Corneal pigmentations and deposits	0.514	0.486
M75.81 Other shoulder lesions, right shoulder	0.514	0.486
M73.8 Other soft tissue disorders in diseases classified elsewhere	0.514	0.486
M73.1 Syphilitic bursitis	0.514	0.486
M73.0 Gonococcal bursitis	0.514	0.486
Q85.9 Phakomatosis, unspecified	0.514	0.486
H22 Disorders of iris and ciliary body in diseases classified elsewhere	0.514	0.486
M40.2 Other and unspecified kyphosis	0.514	0.486
E12.9 Without complications	0.513	0.486
E12.8 With unspecified complications	0.513	0.486
E12.7 With multiple complications	0.513	0.486
E12.6 With other specified complications	0.513	0.486
E12.5 With peripheral circulatory complications	0.513	0.486
E12.4 With neurological complications	0.513	0.486
E12.3 With ophthalmic complications	0.513	0.486
E12.2 With renal complications	0.513	0.486
E12.1 With ketoacidosis	0.513	0.486
E12.0 With coma	0.513	0.486
C02.9 Tongue, unspecified	0.513	0.486
M23.47 Loose body in knee-Capsular lig	0.512	0.488
M23.45 Loose body in knee-Pst hrn lat men	0.512	0.488
M23.44 Loose body in knee-Lat lig/ant men	0.512	0.488
M23.42 Loose body in knee-Pst lig/hrn men	0.512	0.488
M23.41 Loose body in knee-Ant lig/hrn men	0.512	0.488
M23.40 Loose body in knee-Mult sites	0.512	0.488
X00-X09 Exposure to smoke, fire and flames	0.512	0.488
M21.37 Wrist or foot drop (acquired) (Ankle and foot)	0.512	0.488
M21.2 Flexion deformity	0.512	0.488
M68.8 Other disorders of synovium and tendon in diseases classified elsewhere	0.511	0.488
M68.0 Synovitis and tenosynovitis in bacterial diseases classified elsewhere	0.511	0.488
M24.67 Ankylosis of joint (Ankle and foot)	0.511	0.489
C02.1 Border of tongue	0.511	0.489
M65.09 Abscess of tendon sheath (Site unspecified)	0.510	0.490

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations