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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs10849937
log Bayes Factor = 8.09916
Chromosome 12   position 111,792,427  (GRCh37) Explore rs10849937 on Ensembl!
Variant rs10849937 is part of Cluster X0112

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
I10 Essential (primary) hypertension
0.000 0.001 0.999
E03.9 Hypothyroidism, unspecified
0.000 0.001 0.999
E03 Other hypothyroidism
0.000 0.002 0.998
E00-E07 Disorders of thyroid gland
0.000 0.002 0.998
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.005 0.995
E05.9 Thyrotoxicosis, unspecified
0.000 0.005 0.995
Z95 Presence of cardiac and vascular implants and grafts
0.000 0.010 0.990
Z95.1 Presence of aortocoronary bypass graft
0.000 0.011 0.989
Z95.4 Presence of other heart-valve replacement
0.000 0.019 0.981
Z95.5 Presence of coronary angioplasty implant and graft
0.000 0.023 0.977
Z95.2 Presence of prosthetic heart valve
0.000 0.040 0.960
E07 Other disorders of thyroid
0.000 0.081 0.919
E06 Thyroiditis
0.000 0.094 0.906
E07.9 Disorder of thyroid, unspecified
0.000 0.127 0.873
E04 Other non-toxic goitre
0.000 0.128 0.872
Z95.3 Presence of xenogenic heart valve
0.000 0.151 0.849
E03.8 Other specified hypothyroidism
0.000 0.157 0.843
Z95.8 Presence of other cardiac and vascular implants and grafts
0.000 0.170 0.830
E04.9 Non-toxic goitre, unspecified
0.000 0.192 0.808
E06.3 Autoimmune thyroiditis
0.000 0.202 0.798
E06.9 Thyroiditis, unspecified
0.000 0.237 0.763
E04.1 Non-toxic single thyroid nodule
0.000 0.253 0.747
E05.8 Other thyrotoxicosis
0.000 0.260 0.740
I10-I15 Hypertensive diseases
0.000 0.277 0.723
E03.5 Myxoedema coma
0.000 0.284 0.716
E03.4 Atrophy of thyroid (acquired)
0.000 0.284 0.716
E03.3 Postinfectious hypothyroidism
0.000 0.284 0.716
E03.1 Congenital hypothyroidism without goitre
0.000 0.284 0.716
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.284 0.716
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.284 0.715
E00 Congenital iodine-deficiency syndrome
0.000 0.284 0.715
E05.5 Thyroid crisis or storm
0.000 0.287 0.713
E05.4 Thyrotoxicosis factitia
0.000 0.287 0.713
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.287 0.713
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.287 0.713
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.287 0.713
E07.1 Dyshormogenetic goitre
0.000 0.341 0.659
E07.0 Hypersecretion of calcitonin
0.000 0.341 0.659
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.345 0.655
E04.0 Non-toxic diffuse goitre
0.000 0.348 0.652
E06.4 Drug-induced thyroiditis
0.000 0.351 0.649
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.351 0.649
E06.1 Subacute thyroiditis
0.000 0.351 0.649
E06.0 Acute thyroiditis
0.000 0.351 0.649
I12 Hypertensive renal disease
0.000 0.363 0.637
E04.8 Other specified non-toxic goitre
0.000 0.375 0.625
E06.5 Other chronic thyroiditis
0.000 0.378 0.622
I15 Secondary hypertension
0.000 0.399 0.601
E07.8 Other specified disorders of thyroid
0.000 0.408 0.592
I12.9 Hypertensive renal disease without renal failure
0.000 0.415 0.585
I15.1 Hypertension secondary to other renal disorders
0.000 0.459 0.541
I13 Hypertensive heart and renal disease
0.000 0.481 0.519
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.487 0.513
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.487 0.513
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.487 0.513
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.487 0.513
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.487 0.513
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.487 0.513
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.487 0.513
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.487 0.513
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.490 0.510
I11 Hypertensive heart disease
0.000 0.498 0.502
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.540 0.460
I15.8 Other secondary hypertension
0.000 0.569 0.431
I15.2 Hypertension secondary to endocrine disorders
0.000 0.569 0.431
I12.0 Hypertensive renal disease with renal failure
0.000 0.577 0.423
I15.9 Seconday hypertension, unspecified
0.000 0.593 0.407
Z95.9 Presence of cardiac and vascular implant and graft, unspecified
0.000 0.603 0.396
I15.0 Renovascular hypertension
0.000 0.619 0.381
I13.9 Hypertensive heart and renal disease, unspecified
0.000 0.628 0.372
I13.2 Hypertensive heart and renal disease with both (congestive) heart failure and renal failure
0.000 0.628 0.372
I13.1 Hypertensive heart and renal disease with renal failure
0.000 0.628 0.372
I13.0 Hypertensive heart and renal disease with (congestive) heart failure
0.000 0.628 0.372
I11.0 Hypertensive heart disease with (congestive) heart failure
0.000 0.634 0.366
I11.9 Hypertensive heart disease without (congestive) heart failure
0.000 0.664 0.336
E10.3 With ophthalmic complications
0.000 0.739 0.261
E10 Insulin-dependent diabetes mellitus
0.000 0.749 0.251
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.756 0.244
E10-E14 Diabetes mellitus
0.000 0.765 0.235
E10.4 With neurological complications
0.000 0.786 0.214
E10.9 Without complications
0.000 0.795 0.205
E10.0 With coma
0.000 0.800 0.200
E50-E64 Other nutritional deficiencies
0.000 0.800 0.200
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.802 0.198
E10.5 With peripheral circulatory complications
0.000 0.809 0.191
E10.6 With other specified complications
0.000 0.814 0.186
E10.8 With unspecified complications
0.000 0.819 0.181
E10.2 With renal complications
0.000 0.829 0.170
J34.2 Deviated nasal septum
0.170 0.830 0.000
E12 Malnutrition-related diabetes mellitus
0.000 0.831 0.169
E16 Other disorders of pancreatic internal secretion
0.000 0.836 0.164
E53 Deficiency of other B group vitamins
0.000 0.843 0.157
E55 Vitamin D deficiency
0.000 0.849 0.151
E61 Deficiency of other nutrient elements
0.000 0.849 0.151
E10.1 With ketoacidosis
0.000 0.850 0.150
E16.2 Hypoglycaemia, unspecified
0.000 0.851 0.149
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.857 0.143
E63 Other nutritional deficiencies
0.000 0.857 0.143
E56 Other vitamin deficiencies
0.000 0.857 0.143
E51 Thiamine deficiency
0.000 0.857 0.143
E50 Vitamin A deficiency
0.000 0.857 0.143
E60 Dietary zinc deficiency
0.000 0.857 0.143
E59 Dietary selenium deficiency
0.000 0.857 0.143
E58 Dietary calcium deficiency
0.000 0.857 0.143
E54 Ascorbic acid deficiency
0.000 0.857 0.143
E52 Niacin deficiency [pellagra]
0.000 0.857 0.143
E15 Nondiabetic hypoglycaemic coma
0.000 0.858 0.142
E10.7 With multiple complications
0.000 0.865 0.135
E40-E46 Malnutrition
0.000 0.867 0.133
E53.8 Deficiency of other specified B group vitamins
0.000 0.873 0.127
E13 Other specified diabetes mellitus
0.000 0.874 0.126
E12.9 Without complications
0.000 0.879 0.121
E12.8 With unspecified complications
0.000 0.879 0.121
E12.7 With multiple complications
0.000 0.879 0.121
E12.6 With other specified complications
0.000 0.879 0.121
E12.5 With peripheral circulatory complications
0.000 0.879 0.121
E12.4 With neurological complications
0.000 0.879 0.121
E12.3 With ophthalmic complications
0.000 0.879 0.121
E12.2 With renal complications
0.000 0.879 0.121
E12.1 With ketoacidosis
0.000 0.879 0.121
E12.0 With coma
0.000 0.879 0.121
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.882 0.118
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.882 0.118
E16.4 Abnormal secretion of gastrin
0.000 0.882 0.118
E16.3 Increased secretion of glucagon
0.000 0.882 0.118
E55.9 Vitamin D deficiency, unspecified
0.000 0.884 0.116
E61.2 Magnesium deficiency
0.000 0.887 0.113
E53.1 Pyridoxine deficiency
0.000 0.887 0.113
E53.0 Riboflavin deficiency
0.000 0.887 0.113
E53.9 Vitamin B deficiency, unspecified
0.000 0.888 0.111
E61.1 Iron deficiency
0.000 0.888 0.112
E16.1 Other hypoglycaemia
0.000 0.889 0.111
E55.0 Rickets, active
0.000 0.891 0.108
E61.9 Deficiency of nutrient element, unspecified
0.000 0.892 0.108
E61.8 Deficiency of other specified nutrient elements
0.000 0.892 0.108
E61.7 Deficiency of multiple nutrient elements
0.000 0.892 0.108
E61.6 Vanadium deficiency
0.000 0.892 0.108
E61.5 Molybdenum deficiency
0.000 0.892 0.108
E61.4 Chromium deficiency
0.000 0.892 0.108
E61.3 Manganese deficiency
0.000 0.892 0.108
E61.0 Copper deficiency
0.000 0.892 0.108
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.896 0.104
E50.9 Vitamin A deficiency, unspecified
0.000 0.897 0.103
E50.8 Other manifestations of vitamin A deficiency
0.000 0.897 0.103
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.897 0.103
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.897 0.103
E50.5 Vitamin A deficiency with night blindness
0.000 0.897 0.103
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.897 0.103
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.897 0.103
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.897 0.103
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.897 0.103
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.897 0.103
E51.9 Thiamine deficiency, unspecified
0.000 0.897 0.103
E51.8 Other manifestations of thiamine deficiency
0.000 0.897 0.103
E51.2 Wernicke's encephalopathy
0.000 0.897 0.103
E51.1 Beriberi
0.000 0.897 0.103
E56.9 Vitamin deficiency, unspecified
0.000 0.897 0.103
E56.8 Deficiency of other vitamins
0.000 0.897 0.103
E56.1 Deficiency of vitamin K
0.000 0.897 0.103
E56.0 Deficiency of vitamin E
0.000 0.897 0.103
E63.9 Nutritional deficiency, unspecified
0.000 0.897 0.103
E63.8 Other specified nutritional deficiencies
0.000 0.897 0.103
E63.1 Imbalance of constituents of food intake
0.000 0.897 0.103
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.897 0.103
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.897 0.103
E64.8 Sequelae of other nutritional deficiencies
0.000 0.897 0.103
E64.3 Sequelae of rickets
0.000 0.897 0.103
E64.2 Sequelae of vitamin C deficiency
0.000 0.897 0.103
E64.1 Sequelae of vitamin A deficiency
0.000 0.897 0.103
E64.0 Sequelae of protein-energy malnutrition
0.000 0.897 0.103
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.904 0.095
E45 Retarded development following protein-energy malnutrition
0.000 0.904 0.095
E43 Unspecified severe protein-energy malnutrition
0.000 0.904 0.095
E42 Marasmic kwashiorkor
0.000 0.904 0.095
E41 Nutritional marasmus
0.000 0.904 0.095
E40 Kwashiorkor
0.000 0.904 0.095
E04.2 Non-toxic multinodular goitre
0.001 0.908 0.091
E13.8 With unspecified complications
0.000 0.909 0.090
E13.7 With multiple complications
0.000 0.909 0.090
E13.6 With other specified complications
0.000 0.909 0.090
E13.5 With peripheral circulatory complications
0.000 0.909 0.090
E13.4 With neurological complications
0.000 0.909 0.090
E13.3 With ophthalmic complications
0.000 0.909 0.090
E13.2 With renal complications
0.000 0.909 0.090
E13.1 With ketoacidosis
0.000 0.909 0.090
E13.0 With coma
0.000 0.909 0.090
E65-E68 Obesity and other hyperalimentation
0.000 0.927 0.073
E44.1 Mild protein-energy malnutrition
0.000 0.931 0.069
E44.0 Moderate protein-energy malnutrition
0.000 0.931 0.069
E14 Unspecified diabetes mellitus
0.000 0.931 0.069
E46 Unspecified protein-energy malnutrition
0.000 0.946 0.054
E67 Other hyperalimentation
0.000 0.947 0.053
E68 Sequelae of hyperalimentation
0.000 0.947 0.053
Z95.0 Presence of cardiac pacemaker
0.000 0.948 0.052
E14.4 With neurological complications
0.000 0.948 0.052
E14.6 With other specified complications
0.000 0.948 0.051
E14.2 Withrenal complications
0.000 0.951 0.049
E14.7 With multiple complications
0.000 0.951 0.049
E14.0 With coma
0.000 0.951 0.049
E13.9 Without complications
0.001 0.952 0.048
E14.1 With ketoacidosis
0.000 0.953 0.047
E14.5 With peripheral circulatory complications
0.000 0.955 0.045
E11 Non-insulin-dependent diabetes mellitus
0.000 0.957 0.043
E14.3 With ophthalmic complications
0.000 0.957 0.043
E20-E35 Disorders of other endocrine glands
0.000 0.958 0.042
E11.2 With renal complications
0.000 0.959 0.041
E14.8 With unspecified complications
0.000 0.961 0.039
E67.8 Other specified hyperalimentation
0.000 0.962 0.038
E67.3 Hypervitaminosis D
0.000 0.962 0.038
E67.2 Megavitamin-B6 syndrome
0.000 0.962 0.038
E67.1 Hypercarotenaemia
0.000 0.962 0.038
E67.0 Hypervitaminosis A
0.000 0.962 0.038
E22 Hyperfunction of pituitary gland
0.000 0.964 0.035
E11.4 With neurological complications
0.000 0.964 0.035
E28 Ovarian dysfunction
0.000 0.965 0.035
E65 Localised adiposity
0.000 0.966 0.034
E70-E90 Metabolic disorders
0.000 0.967 0.033
E23 Hypofunction and other disorders of pituitary gland
0.000 0.968 0.031
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.969 0.031
E11.7 With multiple complications
0.000 0.969 0.031
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.970 0.030
E32 Diseases of thymus
0.000 0.970 0.030
E31 Polyglandular dysfunction
0.000 0.970 0.030
E30 Disorders of puberty, not elsewhere classified
0.000 0.970 0.030
E28.3 Primary ovarian failure
0.000 0.970 0.030
E11.0 With coma
0.000 0.970 0.030
E20 Hypoparathyroidism
0.000 0.971 0.029
E23.2 Diabetes insipidus
0.000 0.972 0.028
E22.1 Hyperprolactinaemia
0.000 0.972 0.028
E86 Volume depletion
0.000 0.972 0.028
J34 Other disorders of nose and nasal sinuses
0.028 0.972 0.000
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.973 0.027
E28.2 Polycystic ovarian syndrome
0.000 0.973 0.027
E26 Hyperaldosteronism
0.000 0.974 0.026
E85 Amyloidosis
0.000 0.974 0.026
E25 Adrenogenital disorders
0.000 0.974 0.026
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.974 0.026
E22.8 Other hyperfunction of pituitary gland
0.000 0.974 0.026
E28.9 Ovarian dysfunction, unspecified
0.000 0.974 0.025
E28.8 Other ovarian dysfunction
0.000 0.974 0.025
E28.1 Androgen excess
0.000 0.974 0.025
E28.0 Oestrogen excess
0.000 0.974 0.025
E11.5 With peripheral circulatory complications
0.000 0.975 0.025
E84 Cystic fibrosis
0.000 0.976 0.024
E79 Disorders of purine and pyrimidine metabolism
0.000 0.976 0.024
E77 Disorders of glycoprotein metabolism
0.000 0.976 0.024
E76 Disorders of glycosaminoglycan metabolism
0.000 0.976 0.024
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.976 0.024
E72 Other disorders of amino-acid metabolism
0.000 0.976 0.024
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.976 0.024
E70 Disorders of aromatic amino-acid metabolism
0.000 0.976 0.024
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.976 0.024
E80.4 Gilbert's syndrome
0.000 0.976 0.024
E73 Lactose intolerance
0.000 0.977 0.023
E11.6 With other specified complications
0.000 0.977 0.023
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.977 0.023
E23.1 Drug-induced hypopituitarism
0.000 0.977 0.023
J34.0 Abscess, furuncle and carbuncle of nose
0.023 0.977 0.000
E11.8 With unspecified complications
0.000 0.978 0.022
D89.2 Hypergammaglobulinaemia, unspecified
0.000 0.978 0.022
E34 Other endocrine disorders
0.000 0.978 0.022
E30.9 Disorder of puberty, unspecified
0.000 0.978 0.022
E30.8 Other disorders of puberty
0.000 0.978 0.022
E30.1 Precocious puberty
0.000 0.978 0.022
E30.0 Delayed puberty
0.000 0.978 0.022
E31.9 Polyglandular dysfunction, unspecified
0.000 0.978 0.022
E31.8 Other polyglandular dysfunction
0.000 0.978 0.022
E31.1 Polyglandular hyperfunction
0.000 0.978 0.022
E31.0 Autoimmune polyglandular failure
0.000 0.978 0.022
E32.9 Disease of thymus, unspecified
0.000 0.978 0.022
E32.8 Other diseases of thymus
0.000 0.978 0.022
E32.1 Abscess of thymus
0.000 0.978 0.022
E32.0 Persistent hyperplasia of thymus
0.000 0.978 0.022
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.978 0.022
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.978 0.022
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.978 0.022
J34.1 Cyst and mucocele of nose and nasal sinus
0.022 0.978 0.000
E27 Other disorders of adrenal gland
0.000 0.978 0.022
E23.7 Disorder of pituitary gland, unspecified
0.000 0.978 0.022
E22.0 Acromegaly and pituitary gigantism
0.000 0.979 0.021
E23.6 Other disorders of pituitary gland
0.000 0.979 0.021
E85.9 Amyloidosis, unspecified
0.000 0.979 0.021
K90.0 Coeliac disease
0.000 0.979 0.021
E20.8 Other hypoparathyroidism
0.000 0.979 0.021
E20.1 Pseudohypoparathyroidism
0.000 0.979 0.021
E20.0 Idiopathic hypoparathyroidism
0.000 0.979 0.021
E80.6 Other disorders of bilirubin metabolism
0.000 0.979 0.021
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.980 0.020
E29 Testicular dysfunction
0.000 0.980 0.020
E80.7 Disorder of bilirubin metabolism, unspecified
0.000 0.980 0.020
E80.5 Crigler-Najjar syndrome
0.000 0.980 0.020
E80.3 Defects of catalase and peroxydase
0.000 0.980 0.020
E80.1 Porphyria cutanea tarda
0.000 0.980 0.020
E80.0 Hereditary erythropoietic porphyria
0.000 0.980 0.020
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.980 0.020
E85.4 Organ-limited amyloidosis
0.000 0.980 0.020
E83 Disorders of mineral metabolism
0.000 0.980 0.020
E74 Other disorders of carbohydrate metabolism
0.000 0.980 0.019
E20.9 Hypoparathyroidism, unspecified
0.000 0.981 0.019
D89 Other disorders involving the immune mechanism, not elsewhere classified
0.000 0.981 0.019
E26.9 Hyperaldosteronism, unspecified
0.000 0.981 0.019
E26.8 Other hyperaldosteronism
0.000 0.981 0.019
E26.1 Secondary hyperaldosteronism
0.000 0.981 0.019
E85.8 Other amyloidosis
0.000 0.981 0.019
E85.3 Secondary systemic amyloidosis
0.000 0.981 0.019
E85.2 Heredofamilial amyloidosis, unspecified
0.000 0.981 0.019
E85.1 Neuropathic heredofamilial amyloidosis
0.000 0.981 0.019
E85.0 Nonneuropathic heredofamilial amyloidosis
0.000 0.981 0.019
E25.9 Adrenogenital disorder, unspecified
0.000 0.981 0.019
E25.8 Other adrenogenital disorders
0.000 0.981 0.019
E27.1 Primary adrenocortical insufficiency
0.000 0.981 0.019
E80.2 Other porphyria
0.000 0.981 0.019
E83.4 Disorders of magnesium metabolism
0.000 0.981 0.019
M06.9 Rheumatoid arthritis, unspecified
0.000 0.981 0.019
D86.0 Sarcoidosis of lung
0.000 0.981 0.019
E24 Cushing's syndrome
0.000 0.982 0.018
D23.1 Skin of eyelid, including canthus
0.018 0.982 0.000
E88 Other metabolic disorders
0.000 0.982 0.018
D80-D89 Certain disorders involving the immune mechanism
0.000 0.983 0.017
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.983 0.017
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.983 0.017
E70.3 Albinism
0.000 0.983 0.017
E70.2 Disorders of tyrosine metabolism
0.000 0.983 0.017
E70.1 Other hyperphenylalaninaemias
0.000 0.983 0.017
E70.0 Classical phenylketonuria
0.000 0.983 0.017
E71.3 Disorders of fatty-acid metabolism
0.000 0.983 0.017
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.983 0.017
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.983 0.017
E71.0 Maple-syrup-urine disease
0.000 0.983 0.017
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.983 0.017
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.983 0.017
E72.5 Disorders of glycine metabolism
0.000 0.983 0.017
E72.4 Disorders of ornithine metabolism
0.000 0.983 0.017
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.983 0.017
E72.2 Disorders of urea cycle metabolism
0.000 0.983 0.017
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.000 0.983 0.017
E72.0 Disorders of amino-acid transport
0.000 0.983 0.017
E75.6 Lipid storage disorder, unspecified
0.000 0.983 0.017
E75.5 Other lipid storage disorders
0.000 0.983 0.017
E75.4 Neuronal ceroid lipofuscinosis
0.000 0.983 0.017
E75.3 Sphingolipidosis, unspecified
0.000 0.983 0.017
E75.2 Other sphingolipidosis
0.000 0.983 0.017
E75.1 Other gangliosidosis
0.000 0.983 0.017
E75.0 GM2 gangliosidosis
0.000 0.983 0.017
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.983 0.017
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.983 0.017
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.983 0.017
E76.2 Other mucopolysaccharidoses
0.000 0.983 0.017
E76.1 Mucopolysaccharidosis, type II
0.000 0.983 0.017
E76.0 Mucopolysaccharidosis, type I
0.000 0.983 0.017
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.983 0.017
E77.8 Other disorders of glycoprotein metabolism
0.000 0.983 0.017
E77.1 Defects in glycoprotein degradation
0.000 0.983 0.017
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.983 0.017
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.983 0.017
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.983 0.017
E79.1 Lesch-Nyhan syndrome
0.000 0.983 0.017
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.983 0.017
E84.9 Cystic fibrosis, unspecified
0.000 0.983 0.017
E84.8 Cystic fibrosis with other manifestations
0.000 0.983 0.017
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.983 0.017
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.983 0.017
D86 Sarcoidosis
0.000 0.983 0.017
E11.3 With ophthalmic complications
0.000 0.983 0.017
E23.0 Hypopituitarism
0.000 0.983 0.017
E11.1 With ketoacidosis
0.000 0.983 0.017
E73.8 Other lactose intolerance
0.000 0.983 0.017
E73.1 Secondary lactase deficiency
0.000 0.983 0.017
E73.0 Congenital lactase deficiency
0.000 0.983 0.017
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.983 0.017
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.984 0.016
E73.9 Lactose intolerance, unspecified
0.000 0.984 0.016
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.000 0.984 0.016
E34.5 Androgen resistance syndrome
0.000 0.984 0.016
E34.4 Constitutional tall stature
0.000 0.984 0.016
E34.3 Short stature, not elsewhere classified
0.000 0.984 0.016
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.984 0.016
E34.1 Other hypersecretion of intestinal hormones
0.000 0.984 0.016
E27.5 Adrenomedullary hyperfunction
0.000 0.984 0.016
E27.0 Other adrenocortical overactivity
0.000 0.984 0.016
D89.9 Disorder involving the immune mechanism, unspecified
0.000 0.984 0.015
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.000 0.985 0.015
E26.0 Primary hyperaldosteronism
0.000 0.985 0.015
D86.9 Sarcoidosis, unspecified
0.000 0.985 0.015
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.985 0.015
E14.9 Without complications
0.000 0.985 0.015
E34.8 Other specified endocrine disorders
0.000 0.985 0.015
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.001 0.985 0.015
E27.2 Addisonian crisis
0.000 0.985 0.015
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.985 0.015
E34.0 Carcinoid syndrome
0.000 0.985 0.014
E29.8 Other testicular dysfunction
0.000 0.985 0.014
E29.0 Testicular hyperfunction
0.000 0.985 0.014
E21.4 Other specified disorders of parathyroid gland
0.000 0.985 0.014
E21.2 Other hyperparathyroidism
0.000 0.985 0.014
E88.2 Lipomatosis, not elsewhere classified
0.000 0.986 0.014
E83.9 Disorder of mineral metabolism, unspecified
0.000 0.986 0.014
E83.8 Other disorders of mineral metabolism
0.000 0.986 0.014
E83.2 Disorders of zinc metabolism
0.000 0.986 0.014
E83.0 Disorders of copper metabolism
0.000 0.986 0.014
D89.0 Polyclonal hypergammaglobulinaemia
0.000 0.986 0.014
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.986 0.014
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.986 0.014
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.986 0.014
E74.2 Disorders of galactose metabolism
0.000 0.986 0.014
E74.1 Disorders of fructose metabolism
0.000 0.986 0.014
E74.0 Glycogen storage disease
0.000 0.986 0.014
D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified
0.000 0.986 0.014
D89.3 Immune reconstitution syndrome
0.000 0.986 0.014
E27.8 Other specified disorders of adrenal gland
0.000 0.986 0.014
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.000 0.986 0.014
D84 Other immunodeficiencies
0.000 0.986 0.014
E24.8 Other Cushing's syndrome
0.000 0.987 0.013
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.987 0.013
E24.3 Ectopic ACTH syndrome
0.000 0.987 0.013
E24.1 Nelson's syndrome
0.000 0.987 0.013
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.000 0.987 0.013
E27.9 Disorder of adrenal gland, unspecified
0.000 0.987 0.013
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.987 0.013
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.987 0.013
D83 Common variable immunodeficiency
0.000 0.987 0.013
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.987 0.013
E29.9 Testicular dysfunction, unspecified
0.000 0.987 0.012
M06.98 Rheumatoid arthritis, unspecified (Other)
0.000 0.987 0.013
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.987 0.013
D82 Immunodeficiency associated with other major defects
0.000 0.987 0.013
D81 Combined immunodeficiencies
0.000 0.987 0.013
E83.3 Disorders of phosphorus metabolism
0.000 0.987 0.013
E88.9 Metabolic disorder, unspecified
0.000 0.987 0.012
E88.8 Other specified metabolic disorders
0.000 0.987 0.012
J34.3 Hypertrophy of nasal turbinates
0.013 0.987 0.000
Z12.1 Special screening examination for neoplasm of intestinal tract
0.013 0.987 0.000
D80 Immunodeficiency with predominantly antibody defects
0.000 0.987 0.012
D89.1 Cryoglobulinaemia
0.000 0.988 0.012
E24.0 Pituitary-dependent Cushing's disease
0.000 0.988 0.012
E34.9 Endocrine disorder, unspecified
0.000 0.988 0.012
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes
0.000 0.988 0.012
D84.9 Immunodeficiency, unspecified
0.000 0.989 0.011
D86.8 Sarcoidosis of other and combined sites
0.000 0.989 0.011
D86.1 Sarcoidosis of lymph nodes
0.000 0.989 0.011
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.989 0.011
D86.3 Sarcoidosis of skin
0.000 0.989 0.010
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.989 0.010
K61.0 Anal abscess
0.000 0.989 0.011
D80.2 Selective deficiency of immunoglobulin A [IgA]
0.000 0.989 0.010
E24.2 Drug-induced Cushing's syndrome
0.001 0.989 0.010
D84.8 Other specified immunodeficiencies
0.000 0.990 0.010
D84.1 Defects in the complement system
0.000 0.990 0.010
D84.0 Lymphocyte function antigen-1 [LFA-1] defect
0.000 0.990 0.010
E74.3 Other disorders of intestinal carbohydrate absorption
0.000 0.990 0.010
M06 Other rheumatoid arthritis
0.000 0.990 0.010
E88.3 Tumour lysis syndrome
0.000 0.990 0.010
D83.9 Common variable immunodeficiency, unspecified
0.000 0.990 0.010
E21.3 Hyperparathyroidism, unspecified
0.000 0.990 0.010
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.990 0.010
D83.8 Other common variable immunodeficiencies
0.000 0.990 0.009
D83.2 Common variable immunodeficiency with autoantibodies to B- or T-cells
0.000 0.990 0.009
D83.1 Common variable immunodeficiency with predominant immunoregulatory T-cell disorders
0.000 0.990 0.009
D83.0 Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
0.000 0.990 0.009
E66 Obesity
0.000 0.990 0.010
D81.9 Combined immunodeficiency, unspecified
0.000 0.991 0.009
D81.8 Other combined immunodeficiencies
0.000 0.991 0.009
D81.7 Major histocompatibility complex class II deficiency
0.000 0.991 0.009
D81.6 Major histocompatibility complex class I deficiency
0.000 0.991 0.009
D81.5 Purine nucleoside phosphorylase [PNP] deficiency
0.000 0.991 0.009
D81.4 Nezelof's syndrome
0.000 0.991 0.009
D81.3 Adenosine deaminase [ADA] deficiency
0.000 0.991 0.009
D81.2 Severe combined immunodeficiency [SCID] with low or normal B-cell numbers
0.000 0.991 0.009
D81.1 Severe combined immunodeficiency [SCID] with low T- and B-cell numbers
0.000 0.991 0.009
D81.0 Severe combined immunodeficiency [SCID] with reticular dysgenesis
0.000 0.991 0.009
D82.9 Immunodeficiency associated with major defect, unspecified
0.000 0.991 0.009
D82.8 Immunodeficiency associated with other specified major defects
0.000 0.991 0.009
D82.4 Hyperimmunoglobulin E [IgE] syndrome
0.000 0.991 0.009
D82.3 Immunodeficiency following hereditary defective response to Epstein-Barr virus
0.000 0.991 0.009
D82.2 Immunodeficiency with short-limbed stature
0.000 0.991 0.009
D82.1 Di George's syndrome
0.000 0.991 0.009
D82.0 Wiskott-Aldrich syndrome
0.000 0.991 0.009
E24.9 Cushing's syndrome, unspecified
0.001 0.991 0.009
E83.5 Disorders of calcium metabolism
0.000 0.991 0.009
T92.0 Sequelae of open wound of upper limb
0.009 0.991 0.000
E87 Other disorders of fluid, electrolyte and acid-base balance
0.000 0.991 0.009
E87.8 Other disorders of electrolyte and fluid balance, not elsewhere classified
0.000 0.991 0.009
D80.9 Immunodeficiency with predominantly antibody defects, unspecified
0.000 0.991 0.009
D80.8 Other immunodeficiencies with predominantly antibody defects
0.000 0.991 0.009
D80.7 Transient hypogammaglobulinaemia of infancy
0.000 0.991 0.009
D80.6 Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinaemia
0.000 0.991 0.009
D80.5 Immunodeficiency with increased immunoglobulin M [IgM]
0.000 0.991 0.009
D80.4 Selective deficiency of immunoglobulin M [IgM]
0.000 0.991 0.009
D80.0 Hereditary hypogammaglobulinaemia
0.000 0.991 0.009
E21.0 Primary hyperparathyroidism
0.000 0.991 0.009
N92.0 Excessive and frequent menstruation with regular cycle
0.000 0.991 0.009
M06.3 Rheumatoid nodule
0.000 0.991 0.009
E87.3 Alkalosis
0.000 0.992 0.008
M06.4 Inflammatory polyarthropathy
0.000 0.992 0.008
D80.3 Selective deficiency of immunoglobulin G [IgG] subclasses
0.000 0.992 0.008
T92.9 Sequelae of unspecified injury of upper limb
0.008 0.992 0.000
Z12 Special screening examination for neoplasms
0.008 0.992 0.000
D59.1 Other autoimmune haemolytic anaemias
0.000 0.992 0.008
T92 Sequelae of injuries of upper limb
0.008 0.992 0.000
E29.1 Testicular hypofunction
0.001 0.992 0.008

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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