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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs112243387
log Bayes Factor = 5.91351
Chromosome 21   position 37,649,206  (GRCh37) Explore rs112243387 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
Chapter XIX Injury, poisoning and certain other consequences of external causes
1.000 0.000 0.000
S60-S69 Injuries to the wrist and hand
1.000 0.000 0.000
# Top node
0.999 0.001 0.000
Chapter VII Diseases of the eye and adnexa
0.999 0.001 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.999 0.001 0.000
E10-E14 Diabetes mellitus
0.997 0.003 0.000
E11 Non-insulin-dependent diabetes mellitus
0.996 0.004 0.000
H30-H36 Disorders of choroid and retina
0.995 0.005 0.000
E11.3 With ophthalmic complications
0.995 0.005 0.000
Chapter VI Diseases of the nervous system
0.994 0.006 0.000
H36 Retinal disorders in diseases classified elsewhere
0.993 0.007 0.000
H36.0 Diabetic retinopathy
0.992 0.008 0.000
T36-T50 Poisoning by drugs, medicaments and biological substances
0.991 0.009 0.000
G90-G99 Other disorders of the nervous system
0.984 0.016 0.000
G93 Other disorders of brain
0.980 0.020 0.000
S62 Fracture at wrist and hand level
0.977 0.023 0.000
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]
0.967 0.033 0.000
S66 Injury of muscle and tendon at wrist and hand level
0.967 0.033 0.000
S62.3 Fracture of other metacarpal bone
0.960 0.040 0.000
H15-H22 Disorders of sclera, cornea, iris and ciliary body
0.953 0.047 0.000
E70-E90 Metabolic disorders
0.952 0.048 0.000
S62.30 Fracture of other metacarpal bone (closed)
0.948 0.052 0.000
E87 Other disorders of fluid, electrolyte and acid-base balance
0.947 0.053 0.000
S61 Open wound of wrist and hand
0.947 0.053 0.000
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs
0.946 0.054 0.000
S66.3 Injury of extensor muscle and tendon of other finger at wrist and hand level
0.940 0.060 0.000
H20 Iridocyclitis
0.932 0.068 0.000
H46-H48 Disorders of optic nerve and visual pathways
0.931 0.069 0.000
Chapter I Certain infectious and parasitic diseases
0.930 0.070 0.000
T40.2 Other opioids
0.926 0.074 0.000
E20-E35 Disorders of other endocrine glands
0.920 0.080 0.000
G93.3 Postviral fatigue syndrome
0.919 0.081 0.000
G50-G59 Nerve, nerve root and plexus disorders
0.913 0.087 0.000
E87.5 Hyperkalaemia
0.900 0.100 0.000
S61.9 Open wound of wrist and hand, part unspecified
0.900 0.100 0.000
H55-H59 Other disorders of eye and adnexa
0.899 0.101 0.000
G93.8 Other specified disorders of brain
0.897 0.103 0.000
G93.4 Encephalopathy, unspecified
0.890 0.110 0.000
S50-S59 Injuries to the elbow and forearm
0.890 0.110 0.000
H20.9 Iridocyclitis, unspecified
0.889 0.111 0.000
E11.4 With neurological complications
0.888 0.112 0.000
S63 Dislocation, sprain and strain of joints and ligaments at wrist and hand level
0.888 0.112 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.880 0.120 0.000
S00-S09 Injuries to the head
0.878 0.122 0.000
S68 Traumatic amputation of wrist and hand
0.875 0.125 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.870 0.130 0.000
H47 Other disorders of optic [2nd] nerve and visual pathways
0.869 0.131 0.000
H35 Other retinal disorders
0.863 0.137 0.000
T40.6 Other and unspecified narcotics
0.857 0.143 0.000
A00-A09 Intestinal infectious diseases
0.853 0.147 0.000
E87.6 Hypokalaemia
0.852 0.148 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.850 0.150 0.000
G30-G32 Other degenerative diseases of the nervous system
0.847 0.153 0.000
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.844 0.156 0.000
S64 Injury of nerves at wrist and hand level
0.842 0.158 0.000
S20-S29 Injuries to the thorax
0.839 0.161 0.000
T80-T88 Complications of surgical and medical care, not elsewhere classified
0.839 0.161 0.000
G97 Postprocedural disorders of nervous system, not elsewhere classified
0.833 0.166 0.000
H43-H45 Disorders of vitreous body and globe
0.833 0.167 0.000
T43 Poisoning by psychotropic drugs, not elsewhere classified
0.832 0.168 0.000
H10-H13 Disorders of conjunctiva
0.831 0.169 0.000
G93.6 Cerebral oedema
0.823 0.177 0.000
A04 Other bacterial intestinal infections
0.820 0.180 0.000
T42.0 Hydantoin derivatives
0.819 0.181 0.000
E87.7 Fluid overload
0.818 0.182 0.000
E73 Lactose intolerance
0.817 0.183 0.000
H55 Nystagmus and other irregular eye movements
0.813 0.187 0.000
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system
0.812 0.188 0.000
T85 Complications of other internal prosthetic devices, implants and grafts
0.808 0.192 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.803 0.197 0.000
E11.5 With peripheral circulatory complications
0.803 0.197 0.000
H25-H28 Disorders of lens
0.802 0.198 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.801 0.199 0.000
S02 Fracture of skull and facial bones
0.800 0.200 0.000
T42.1 Iminostilbenes
0.800 0.200 0.000
Chapter X Diseases of the respiratory system
0.799 0.201 0.000
E87.2 Acidosis
0.797 0.203 0.000
S80-S89 Injuries to the knee and lower leg
0.794 0.206 0.000
T42.6 Other antiepileptic and sedative-hypnotic drugs
0.792 0.208 0.000
E21.0 Primary hyperparathyroidism
0.791 0.209 0.000
E11.1 With ketoacidosis
0.787 0.213 0.000
G30 Alzheimer's disease
0.787 0.213 0.000
J40-J47 Chronic lower respiratory diseases
0.783 0.217 0.000
T85.5 Mechanical complication of gastro-intestinal prosthetic devices, implants and grafts
0.780 0.220 0.000
S10-S19 Injuries to the neck
0.779 0.221 0.000
T88 Other complications of surgical and medical care, not elsewhere classified
0.777 0.223 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.775 0.225 0.000
S22 Fracture of rib(s), sternum and thoracic spine
0.774 0.226 0.000
E87.8 Other disorders of electrolyte and fluid balance, not elsewhere classified
0.774 0.226 0.000
E22 Hyperfunction of pituitary gland
0.770 0.230 0.000
H47.0 Disorders of optic nerve, not elsewhere classified
0.769 0.231 0.000
E14 Unspecified diabetes mellitus
0.767 0.233 0.000
G93.0 Cerebral cysts
0.766 0.234 0.000
A04.7 Enterocolitis due to Clostridium difficile
0.766 0.234 0.000
S63.6 Sprain and strain of finger(s)
0.766 0.234 0.000
B99-B99 Other infectious diseases
0.763 0.237 0.000
G58 Other mononeuropathies
0.763 0.237 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.761 0.239 0.000
S62.6 Fracture of other finger
0.761 0.239 0.000
H20.1 Chronic iridocyclitis
0.756 0.244 0.000
E65-E68 Obesity and other hyperalimentation
0.755 0.245 0.000
G57 Mononeuropathies of lower limb
0.755 0.245 0.000
E11.2 With renal complications
0.755 0.245 0.000
G59 Mononeuropathy in diseases classified elsewhere
0.754 0.246 0.000
T46 Poisoning by agents primarily affecting the cardiovascular system
0.754 0.246 0.000
H20.8 Other iridocyclitis
0.752 0.248 0.000
S68.1 Traumatic amputation of other single finger (complete)(partial)
0.752 0.248 0.000
S02.4 Fracture of malar and maxillary bones
0.752 0.248 0.000
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified
0.751 0.249 0.000
E13 Other specified diabetes mellitus
0.750 0.250 0.000
G80-G83 Cerebral palsy and other paralytic syndromes
0.748 0.252 0.000
H35.0 Background retinopathy and retinal vascular changes
0.747 0.253 0.000
S65 Injury of blood vessels at wrist and hand level
0.746 0.254 0.000
S61.1 Open wound of finger(s) with damage to nail
0.745 0.255 0.000
G53 Cranial nerve disorders in diseases classified elsewhere
0.745 0.255 0.000
B65-B83 Helminthiases
0.744 0.256 0.000
G30.9 Alzheimer's disease, unspecified
0.744 0.256 0.000
S66.0 Injury of long flexor muscle and tendon of thumb at wrist and hand level
0.742 0.258 0.000
J80-J84 Other respiratory diseases principally affecting the interstitium
0.741 0.259 0.000
E83 Disorders of mineral metabolism
0.740 0.260 0.000
T47 Poisoning by agents primarily affecting gastro-intestinal system
0.739 0.261 0.000
T85.7 Infection and inflammatory reaction due to other internal prosthetic devices, implants and grafts
0.738 0.262 0.000
S60 Superficial injury of wrist and hand
0.738 0.262 0.000
Chapter XXII Codes for special purposes
0.737 0.263 0.000
S51 Open wound of forearm
0.736 0.264 0.000
H35.6 Retinal haemorrhage
0.736 0.264 0.000
T58 Toxic effect of carbon monoxide
0.734 0.265 0.000
G55 Nerve root and plexus compressions in diseases classified elsewhere
0.734 0.266 0.000
A50-A64 Infections with a predominantly sexual mode of transmission
0.731 0.269 0.000
H57 Other disorders of eye and adnexa
0.731 0.269 0.000
H20.0 Acute and subacute iridocyclitis
0.730 0.270 0.000
T90 Sequelae of injuries of head
0.729 0.270 0.000
T92 Sequelae of injuries of upper limb
0.729 0.271 0.000
J46 Status asthmaticus
0.729 0.271 0.000
T42.4 Benzodiazepines
0.728 0.272 0.000
H47.2 Optic atrophy
0.728 0.272 0.000
H35.5 Hereditary retinal dystrophy
0.728 0.272 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.725 0.275 0.000
H46 Optic neuritis
0.724 0.276 0.000
G93.1 Anoxic brain damage, not elsewhere classified
0.724 0.276 0.000
S63.4 Traumatic rupture of ligament of finger at metacarpophalangeal and interphalangeal joint(s)
0.722 0.278 0.000
E73.9 Lactose intolerance, unspecified
0.721 0.279 0.000
S66.1 Injury of flexor muscle and tendon of other finger at wrist and hand level
0.720 0.280 0.000
Chapter XX External causes of morbidity and mortality
0.719 0.281 0.000
J45 Asthma
0.719 0.281 0.000
H26 Other cataract
0.719 0.281 0.000
S02.40 Fracture of malar and maxillary bones (closed)
0.718 0.282 0.000
T33-T35 Frostbite
0.717 0.283 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.717 0.283 0.000
T00-T07 Injuries involving multiple body regions
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.716 0.284 0.000
S02.3 Fracture of orbital floor
0.715 0.285 0.000
G54 Nerve root and plexus disorders
0.715 0.285 0.000
E12 Malnutrition-related diabetes mellitus
0.715 0.285 0.000
B50-B64 Protozoal diseases
0.715 0.285 0.000
S61.8 Open wound of other parts of wrist and hand
0.715 0.285 0.000
G09 Sequelae of inflammatory diseases of central nervous system
0.715 0.285 0.000
E11.8 With unspecified complications
0.714 0.286 0.000
E11.7 With multiple complications
0.714 0.286 0.000
E11.0 With coma
0.714 0.286 0.000
G96 Other disorders of central nervous system
0.714 0.286 0.000
H32 Chorioretinal disorders in diseases classified elsewhere
0.713 0.286 0.000
H30 Chorioretinal inflammation
0.713 0.286 0.000
S05 Injury of eye and orbit
0.713 0.287 0.000
S62.5 Fracture of thumb
0.713 0.287 0.000
H36.8 Other retinal disorders in diseases classified elsewhere
0.712 0.288 0.000
E85 Amyloidosis
0.711 0.289 0.000
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs
0.710 0.289 0.000
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system
0.710 0.289 0.000
T41 Poisoning by anaesthetics and therapeutic gases
0.710 0.289 0.000
T37 Poisoning by other systemic anti-infectives and antiparasitics
0.710 0.289 0.000
T36 Poisoning by systemic antibiotics
0.710 0.289 0.000
J84 Other interstitial pulmonary diseases
0.710 0.290 0.000
E20 Hypoparathyroidism
0.709 0.291 0.000
S62.4 Multiple fractures of metacarpal bones
0.709 0.291 0.000
E14.3 With ophthalmic complications
0.708 0.292 0.000
S53 Dislocation, sprain and strain of joints and ligaments of elbow
0.706 0.293 0.000
T88.6 Anaphylactic shock due to adverse effect of correct drug or medicament properly administered
0.706 0.294 0.000
G94 Other disorders of brain in diseases classified elsewhere
0.706 0.294 0.000
G98 Other disorders of nervous system, not elsewhere classified
0.706 0.294 0.000
G92 Toxic encephalopathy
0.706 0.294 0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.705 0.295 0.000
G93.7 Reye's syndrome
0.702 0.298 0.000
G93.5 Compression of brain
0.702 0.298 0.000
S62.7 Multiple fractures of fingers
0.700 0.300 0.000
S62.1 Fracture of other carpal bone(s)
0.700 0.300 0.000
H35.4 Peripheral retinal degeneration
0.700 0.300 0.000
S69 Other and unspecified injuries of wrist and hand
0.700 0.300 0.000
S82 Fracture of lower leg, including ankle
0.700 0.300 0.000
S64.0 Injury of ulnar nerve at wrist and hand level
0.699 0.301 0.000
B95-B98 Bacterial, viral and other infectious agents
0.698 0.302 0.000
J45.9 Asthma, unspecified
0.698 0.302 0.000
E87.3 Alkalosis
0.697 0.303 0.000
G90 Disorders of autonomic nervous system
0.696 0.304 0.000
E11.6 With other specified complications
0.696 0.304 0.000
S01 Open wound of head
0.696 0.304 0.000
A30-A49 Other bacterial diseases
0.695 0.305 0.000
S62.0 Fracture of navicular [scaphoid] bone of hand
0.694 0.306 0.000
T40.9 Other and unspecified psychodysleptics [hallucinogens]
0.693 0.306 0.000
T40.8 Lysergide [LSD]
0.693 0.306 0.000
T40.7 Cannabis (derivatives)
0.693 0.306 0.000
T40.5 Cocaine
0.693 0.306 0.000
T40.3 Methadone
0.693 0.306 0.000
T40.1 Heroin
0.693 0.306 0.000
T40.0 Opium
0.693 0.306 0.000
S66.9 Injury of unspecified muscle and tendon at wrist and hand level
0.693 0.307 0.000
S66.8 Injury of other muscles and tendons at wrist and hand level
0.693 0.307 0.000
S66.6 Injury of multiple flexor muscles and tendons at wrist and hand level
0.693 0.307 0.000
S66.5 Injury of intrinsic muscle and tendon of other finger at wrist and hand level
0.693 0.307 0.000
S66.4 Injury of intrinsic muscle and tendon of thumb at wrist and hand level
0.693 0.307 0.000
S68.2 Traumatic amputation of two or more fingers alone (complete)(partial)
0.693 0.307 0.000
A80-A89 Viral infections of the central nervous system
0.692 0.308 0.000
S66.7 Injury of multiple extensor muscles and tendons at wrist and hand level
0.691 0.309 0.000
T66-T78 Other and unspecified effects of external causes
0.690 0.309 0.000
S59 Other and unspecified injuries of forearm
0.690 0.310 0.000
S52 Fracture of forearm
0.690 0.310 0.000
T40.4 Other synthetic narcotics
0.689 0.311 0.000
E28 Ovarian dysfunction
0.689 0.311 0.000
S22.4 Multiple fractures of ribs
0.689 0.311 0.000
S62.31 Fracture of other metacarpal bone (open)
0.688 0.312 0.000
J42 Unspecified chronic bronchitis
0.684 0.316 0.000
H22 Disorders of iris and ciliary body in diseases classified elsewhere
0.683 0.316 0.000
H19 Disorders of sclera and cornea in diseases classified elsewhere
0.683 0.316 0.000
H17 Corneal scars and opacities
0.683 0.316 0.000
H15 Disorders of sclera
0.683 0.316 0.000
E84 Cystic fibrosis
0.682 0.318 0.000
E79 Disorders of purine and pyrimidine metabolism
0.682 0.318 0.000
E77 Disorders of glycoprotein metabolism
0.682 0.318 0.000
E76 Disorders of glycosaminoglycan metabolism
0.682 0.318 0.000
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.682 0.318 0.000
E74 Other disorders of carbohydrate metabolism
0.682 0.318 0.000
E72 Other disorders of amino-acid metabolism
0.682 0.318 0.000
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.682 0.318 0.000
E70 Disorders of aromatic amino-acid metabolism
0.682 0.318 0.000
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.682 0.318 0.000
H31 Other disorders of choroid
0.682 0.318 0.000
G06 Intracranial and intraspinal abscess and granuloma
0.681 0.319 0.000
G00 Bacterial meningitis, not elsewhere classified
0.681 0.319 0.000
S62.60 Fracture of other finger (closed)
0.680 0.320 0.000
S61.7 Multiple open wounds of wrist and hand
0.679 0.321 0.000
E87.4 Mixed disorder of acid-base balance
0.679 0.321 0.000
H44 Disorders of globe
0.678 0.321 0.000
T42.8 Anti-Parkinsonism drugs and other central muscle-tone depressants
0.678 0.322 0.000
T42.7 Antiepileptic and sedative-hypnotic drugs, unspecified
0.678 0.322 0.000
T42.5 Mixed antiepileptics, not elsewhere classified
0.678 0.322 0.000
T42.3 Barbiturates
0.678 0.322 0.000
T42.2 Succinimides and oxazolidinediones
0.678 0.322 0.000
G58.9 Mononeuropathy, unspecified
0.677 0.323 0.000
T43.5 Other and unspecified antipsychotics and neuroleptics
0.676 0.324 0.000
G50 Disorders of trigeminal nerve
0.676 0.324 0.000
B20-B24 Human immunodeficiency virus [HIV] disease
0.675 0.325 0.000
S62.2 Fracture of first metacarpal bone
0.675 0.325 0.000
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.674 0.325 0.000
Q10-Q18 Congenital malformations of eye, ear, face and neck
0.674 0.326 0.000
G97.1 Other reaction to spinal and lumbar puncture
0.674 0.326 0.000
G97.8 Other postprocedural disorders of nervous system
0.674 0.326 0.000
G91 Hydrocephalus
0.673 0.326 0.000
H26.4 After-cataract
0.673 0.327 0.000
H21 Other disorders of iris and ciliary body
0.672 0.328 0.000
H35.7 Separation of retinal layers
0.672 0.328 0.000
T63 Toxic effect of contact with venomous animals
0.671 0.329 0.000
H10 Conjunctivitis
0.670 0.330 0.000
G04 Encephalitis, myelitis and encephalomyelitis
0.669 0.331 0.000
T11 Other injuries of upper limb, level unspecified
0.669 0.331 0.000
H20.2 Lens-induced iridocyclitis
0.668 0.332 0.000
H16 Keratitis
0.668 0.332 0.000
T86 Failure and rejection of transplanted organs and tissues
0.668 0.332 0.000
H48 Disorders of optic [2nd] nerve and visual pathways in diseases classified elsewhere
0.668 0.332 0.000
B85-B89 Pediculosis, acariasis and other infestations
0.667 0.333 0.000
A92-A99 Arthropod-borne viral fevers and viral haemorrhagic fevers
0.667 0.333 0.000
A75-A79 Rickettsioses
0.667 0.333 0.000
A70-A74 Other diseases caused by chlamydiae
0.667 0.333 0.000
A65-A69 Other spirochaetal diseases
0.667 0.333 0.000
A20-A28 Certain zoonotic bacterial diseases
0.667 0.333 0.000
A15-A19 Tuberculosis
0.667 0.333 0.000
A04.5 Campylobacter enteritis
0.666 0.334 0.000
A08 Viral and other specified intestinal infections
0.665 0.335 0.000
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.663 0.337 0.000
J84.1 Other interstitial pulmonary diseases with fibrosis
0.663 0.337 0.000
T79-T79 Certain early complications of trauma
0.661 0.339 0.000
A04.8 Other specified bacterial intestinal infections
0.661 0.339 0.000
E35 Disorders of endocrine glands in diseases classified elsewhere
0.660 0.340 0.000
E32 Diseases of thymus
0.660 0.340 0.000
E31 Polyglandular dysfunction
0.660 0.340 0.000
E30 Disorders of puberty, not elsewhere classified
0.660 0.340 0.000
E26 Hyperaldosteronism
0.660 0.340 0.000
E25 Adrenogenital disorders
0.660 0.340 0.000
E24 Cushing's syndrome
0.660 0.340 0.000
J44 Other chronic obstructive pulmonary disease
0.660 0.340 0.000
T17 Foreign body in respiratory tract
0.660 0.340 0.000
E27 Other disorders of adrenal gland
0.657 0.343 0.000
G08 Intracranial and intraspinal phlebitis and thrombophlebitis
0.656 0.344 0.000
H47.1 Papilloedema, unspecified
0.656 0.344 0.000
S64.2 Injury of radial nerve at wrist and hand level
0.656 0.344 0.000
G52 Disorders of other cranial nerves
0.655 0.345 0.000
H11 Other disorders of conjunctiva
0.655 0.345 0.000
S02.30 Fracture of orbital floor (closed)
0.654 0.346 0.000
B90-B94 Sequelae of infectious and parasitic diseases
0.654 0.346 0.000
G57.6 Lesion of plantar nerve
0.654 0.346 0.000
E88 Other metabolic disorders
0.653 0.347 0.000
T87 Complications peculiar to reattachment and amputation
0.653 0.347 0.000
H43 Disorders of vitreous body
0.653 0.347 0.000
T59 Toxic effect of other gases, fumes and vapours
0.652 0.348 0.000
T98 Sequelae of other and unspecified effects of external causes
0.652 0.348 0.000
E40-E46 Malnutrition
0.651 0.349 0.000
H47.3 Other disorders of optic disk
0.650 0.350 0.000
G93.9 Disorder of brain, unspecified
0.650 0.350 0.000
G93.2 Benign intracranial hypertension
0.647 0.353 0.000
S62.8 Fracture of other and unspecified parts of wrist and hand
0.647 0.353 0.000
S64.1 Injury of median nerve at wrist and hand level
0.646 0.354 0.000
T88.4 Failed or difficult intubation
0.644 0.355 0.000
S66.2 Injury of extensor muscle and tendon of thumb at wrist and hand level
0.644 0.356 0.000
B99 Other and unspecified infectious diseases
0.643 0.357 0.000
T88.8 Other specified complications of surgical and medical care, not elsewhere classified
0.642 0.358 0.000
G59.0 Diabetic mononeuropathy
0.641 0.359 0.000
E83.3 Disorders of phosphorus metabolism
0.641 0.359 0.000
T85.2 Mechanical complication of intraocular lens
0.639 0.361 0.000
S58 Traumatic amputation of forearm
0.638 0.362 0.000
S57 Crushing injury of forearm
0.638 0.362 0.000
S55 Injury of blood vessels at forearm level
0.638 0.362 0.000
S54 Injury of nerves at forearm level
0.638 0.362 0.000
H58 Other disorders of eye and adnexa in diseases classified elsewhere
0.636 0.363 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.637 0.363 0.000
S63.1 Dislocation finger
0.636 0.363 0.000
S63.7 Sprain and strain of other and unspecified parts of hand
0.636 0.363 0.000
S63.5 Sprain and strain of wrist
0.636 0.363 0.000
S63.3 Traumatic rupture of ligament of wrist and carpus
0.636 0.363 0.000
S63.2 Multiple dislocations of fingers
0.636 0.363 0.000
S63.0 Dislocation of wrist
0.636 0.363 0.000
S01.8 Open wound of other parts of head
0.636 0.364 0.000
J95-J99 Other diseases of the respiratory system
0.634 0.366 0.000
E87.1 Hypo-osmolality and hyponatraemia
0.634 0.366 0.000
S67 Crushing injury of wrist and hand
0.633 0.366 0.000
S56 Injury of muscle and tendon at forearm level
0.633 0.367 0.000
E34 Other endocrine disorders
0.632 0.368 0.000
G05 Encephalitis, myelitis and encephalomyelitis in diseases classified elsewhere
0.631 0.369 0.000
G02 Meningitis in other infectious and parasitic diseases classified elsewhere
0.631 0.369 0.000
G07 Intracranial and intraspinal abscess and granuloma in diseases classified elsewhere
0.631 0.369 0.000
G01 Meningitis in bacterial diseases classified elsewhere
0.631 0.369 0.000
H27 Other disorders of lens
0.630 0.370 0.000
S08 Traumatic amputation of part of head
0.630 0.370 0.000
S07 Crushing injury of head
0.630 0.370 0.000
S04 Injury of cranial nerves
0.630 0.370 0.000
S03 Dislocation, sprain and strain of joints and ligaments of head
0.630 0.370 0.000
G03 Meningitis due to other and unspecified causes
0.629 0.371 0.000
B15-B19 Viral hepatitis
0.629 0.371 0.000
T44 Poisoning by drugs primarily affecting the autonomic nervous system
0.628 0.372 0.000
S22.40 Multiple fractures of ribs (closed)
0.627 0.373 0.000
S68.9 Traumatic amputation of wrist and hand, level unspecified
0.627 0.373 0.000
S68.8 Traumatic amputation of other parts of wrist and hand
0.627 0.373 0.000
S68.4 Traumatic amputation of hand at wrist level
0.627 0.373 0.000
S68.3 Combined traumatic amputation of (part of) finger(s) with other parts of wrist and hand
0.627 0.373 0.000
S68.0 Traumatic amputation of thumb (complete)(partial)
0.627 0.373 0.000
T43.0 Tricyclic and tetracyclic antidepressants
0.627 0.373 0.000
H35.2 Other proliferative retinopathy
0.626 0.374 0.000
B00-B09 Viral infections characterized by skin and mucous membrane lesions
0.625 0.375 0.000
T43.3 Phenothiazine antipsychotics and neuroleptics
0.625 0.375 0.000
T95 Sequelae of burns, corrosions and frostbite
0.624 0.376 0.000
T94 Sequelae of injuries involving multiple and unspecified body regions
0.624 0.376 0.000
T97 Sequelae of toxic effects of substances chiefly nonmedicinal as to source
0.624 0.376 0.000
T96 Sequelae of poisoning by drugs, medicaments and biological substances
0.624 0.376 0.000
G53.0 Postzoster neuralgia
0.624 0.376 0.000
H47.7 Disorder of visual pathways, unspecified
0.623 0.377 0.000
H47.6 Disorders of visual cortex
0.623 0.377 0.000
H47.5 Disorders of other visual pathways
0.623 0.377 0.000
H47.4 Disorders of optic chiasm
0.623 0.377 0.000
G60 Hereditary and idiopathic neuropathy
0.622 0.377 0.000
G99 Other disorders of nervous system in diseases classified elsewhere
0.622 0.378 0.000
Q50-Q56 Congenital malformations of genital organs
0.621 0.379 0.000
S82.8 Fractures of other parts of lower leg
0.620 0.380 0.000
S64.3 Injury of digital nerve of thumb
0.619 0.381 0.000
H35.1 Retinopathy of prematurity
0.619 0.381 0.000
H57.9 Disorder of eye and adnexa, unspecified
0.617 0.383 0.000
E10 Insulin-dependent diabetes mellitus
0.617 0.383 0.000
S19 Other and unspecified injuries of neck
0.616 0.384 0.000
S90-S99 Injuries to the ankle and foot
0.616 0.384 0.000
J84.9 Interstitial pulmonary disease, unspecified
0.616 0.384 0.000
B98 Other specified infectious agents as the cause of diseases classified to other chapters
0.616 0.384 0.000
T91 Sequelae of injuries of neck and trunk
0.615 0.385 0.000
S50 Superficial injury of forearm
0.614 0.386 0.000
G63 Polyneuropathy in diseases classified elsewhere
0.613 0.387 0.000
A07 Other protozoal intestinal diseases
0.612 0.388 0.000
A06 Amoebiasis
0.612 0.388 0.000
A05 Other bacterial foodborne intoxications
0.612 0.388 0.000
A03 Shigellosis
0.612 0.388 0.000
A02 Other Salmonella infections
0.612 0.388 0.000
A01 Typhoid and paratyphoid fevers
0.612 0.388 0.000
A00 Cholera
0.612 0.388 0.000
E66 Obesity
0.610 0.389 0.000
G62 Other polyneuropathies
0.610 0.390 0.000
S89 Other and unspecified injuries of lower leg
0.610 0.390 0.000
B80 Enterobiasis
0.610 0.390 0.000
T65 Toxic effect of other and unspecified substances
0.610 0.390 0.000
T62 Toxic effect of other noxious substances eaten as food
0.610 0.390 0.000
T61 Toxic effect of noxious substances eaten as seafood
0.610 0.390 0.000
T60 Toxic effect of pesticides
0.610 0.390 0.000
T57 Toxic effect of other inorganic substances
0.610 0.390 0.000
T56 Toxic effect of metals
0.610 0.390 0.000
T54 Toxic effect of corrosive substances
0.610 0.390 0.000
T53 Toxic effect of halogen derivatives of aliphatic and aromatic hydrocarbone
0.610 0.390 0.000
T52 Toxic effect of organic solvents
0.610 0.390 0.000
T64 Toxic effect of aflatoxin and other mycotoxin food contaminants
0.610 0.390 0.000
T55 Toxic effect of soaps and detergents
0.610 0.390 0.000
S02.9 Fracture of skull and facial bones, part unspecified
0.609 0.391 0.000
S61.0 Open wound of finger(s) without damage to nail
0.609 0.391 0.000
E23 Hypofunction and other disorders of pituitary gland
0.608 0.391 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.608 0.391 0.000
S52.0 Fracture of upper end of ulna
0.608 0.392 0.000
G83 Other paralytic syndromes
0.608 0.392 0.000
T43.2 Other and unspecified antidepressants
0.607 0.393 0.000
G32 Other degenerative disorders of nervous system in diseases classified elsewhere
0.607 0.393 0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.607 0.393 0.000
J82 Pulmonary eosinophilia, not elsewhere classified
0.605 0.395 0.000
E21.5 Disorder of parathyroid gland, unspecified
0.605 0.395 0.000
E21.4 Other specified disorders of parathyroid gland
0.605 0.395 0.000
E21.2 Other hyperparathyroidism
0.605 0.395 0.000
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.605 0.395 0.000
G61 Inflammatory polyneuropathy
0.605 0.395 0.000
S64.9 Injury of unspecified nerve at wrist and hand level
0.604 0.396 0.000
S64.8 Injury of other nerves at wrist and hand level
0.604 0.396 0.000
S64.7 Injury of multiple nerves at wrist and hand level
0.604 0.396 0.000
S28 Crushing injury of thorax and traumatic amputation of part of thorax
0.602 0.398 0.000
S26 Injury of heart
0.602 0.398 0.000
S25 Injury of blood vessels of thorax
0.602 0.398 0.000
S24 Injury of nerves and spinal cord at thorax level
0.602 0.398 0.000
S23 Dislocation, sprain and strain of joints and ligaments of thorax
0.602 0.398 0.000
S21 Open wound of thorax
0.602 0.398 0.000
S86 Injury of muscle and tendon at lower leg level
0.601 0.398 0.000
E87.0 Hyperosmolality and hypernatraemia
0.601 0.399 0.000
S82.2 Fracture of shaft of tibia
0.601 0.399 0.000
S22.2 Fracture of sternum
0.599 0.401 0.000
S22.0 Fracture of thoracic vertebra
0.599 0.401 0.000
G97.9 Postprocedural disorder of nervous system, unspecified
0.598 0.402 0.000
G97.2 Intracranial hypotension following ventricular shunting
0.598 0.402 0.000
G97.0 Cerebrospinal fluid leak from spinal puncture
0.598 0.402 0.000
H45 Disorders of vitreous body and globe in diseases classified elsewhere
0.597 0.402 0.000
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances
0.597 0.403 0.000
T43.9 Psychotropic drug, unspecified
0.596 0.403 0.000
T43.8 Other psychotropic drugs, not elsewhere classified
0.596 0.403 0.000
T43.6 Psychostimulants with abuse potential
0.596 0.403 0.000
T43.4 Butyrophenone and thioxanthene neuroleptics
0.596 0.403 0.000
T43.1 Monoamine-oxidase-inhibitor antidepressants
0.596 0.403 0.000
H13 Disorders of conjunctiva in diseases classified elsewhere
0.596 0.404 0.000
E21.3 Hyperparathyroidism, unspecified
0.595 0.404 0.000
E80 Disorders of porphyrin and bilirubin metabolism
0.595 0.405 0.000
S01.5 Open wound of lip and oral cavity
0.595 0.405 0.000
Q00-Q07 Congenital malformations of the nervous system
0.593 0.407 0.000
S82.5 Fracture of medial malleolus
0.593 0.407 0.000
G55.8 Nerve root and plexus compressions in other diseases classified elsewhere
0.593 0.407 0.000
S22.3 Fracture of rib
0.593 0.407 0.000
E22.1 Hyperprolactinaemia
0.591 0.409 0.000
T90.9 Sequelae of unspecified injury of head
0.590 0.410 0.000
S51.9 Open wound of forearm, part unspecified
0.588 0.411 0.000
A04.9 Bacterial intestinal infection, unspecified
0.588 0.412 0.000
A04.6 Enteritis due to Yersinia enterocolitica
0.588 0.412 0.000
A04.4 Other intestinal Escherichia coli infections
0.588 0.412 0.000
A04.3 Enterohaemorrhagic Escherichia coli infection
0.588 0.412 0.000
A04.2 Enteroinvasive Escherichia coli infection
0.588 0.412 0.000
A04.1 Enterotoxigenic Escherichia coli infection
0.588 0.412 0.000
A04.0 Enteropathogenic Escherichia coli infection
0.588 0.412 0.000
S12 Fracture of neck
0.586 0.414 0.000
B97 Viral agents as the cause of diseases classified to other chapters
0.586 0.414 0.000
E73.8 Other lactose intolerance
0.586 0.414 0.000
E73.1 Secondary lactase deficiency
0.586 0.414 0.000
E73.0 Congenital lactase deficiency
0.586 0.414 0.000
B25-B34 Other viral diseases
0.586 0.414 0.000
H59 Postprocedural disorders of eye and adnexa, not elsewhere classified
0.585 0.415 0.000
J40 Bronchitis, not specified as acute or chronic
0.584 0.416 0.000
S02.0 Fracture of vault of skull
0.583 0.416 0.000
W50-W64 Exposure to animate mechanical forces
0.583 0.416 0.000
H34 Retinal vascular occlusions
0.583 0.417 0.000
G64 Other disorders of peripheral nervous system
0.582 0.418 0.000
S05.1 Contusion of eyeball and orbital tissues
0.582 0.418 0.000
X20-X29 Contact with venomous animals and plants
0.580 0.420 0.000
J44.1 Chronic obstructive pulmonary disease with acute exacerbation, unspecified
0.580 0.420 0.000
T85.9 Unspecified complication of internal prosthetic device, implant and graft
0.579 0.420 0.000
T85.1 Mechanical complication of implanted electronic stimulator of nervous system
0.579 0.420 0.000
T85.0 Mechanical complication of ventricular intracranial (communicating) shunt
0.579 0.420 0.000
V80-V89 Other land transport accidents
0.579 0.421 0.000
H26.1 Traumatic cataract
0.579 0.421 0.000
T90.2 Sequelae of fracture of skull and facial bones
0.579 0.421 0.000
T45.0 Antiallergic and antiemetic drugs
0.578 0.421 0.000
S81 Open wound of lower leg
0.578 0.422 0.000
H26.2 Complicated cataract
0.578 0.422 0.000
G55.2 Nerve root and plexus compressions in spondylosis
0.577 0.423 0.000
T13 Other injuries of lower limb, level unspecified
0.576 0.424 0.000
T09 Other injuries of spine and trunk, level unspecified
0.576 0.424 0.000
T12.X1 Fracture of lower limb, level unspecified (open)
0.576 0.424 0.000
T12.X0 Fracture of lower limb, level unspecified (closed)
0.576 0.424 0.000
T12 Fracture of lower limb, level unspecified
0.576 0.424 0.000
T10.X1 Fracture of upper limb, level unspecified (open)
0.576 0.424 0.000
T10.X0 Fracture of upper limb, level unspecified (closed)
0.576 0.424 0.000
T10 Fracture of upper limb, level unspecified
0.576 0.424 0.000
T08.X1 Fracture of spine, level unspecified (open)
0.576 0.424 0.000
T08.X0 Fracture of spine, level unspecified (closed)
0.576 0.424 0.000
T08 Fracture of spine, level unspecified
0.576 0.424 0.000
E66.8 Other obesity
0.576 0.424 0.000
E29 Testicular dysfunction
0.575 0.424 0.000
S53.3 Traumatic rupture of ulnar collateral ligament
0.575 0.425 0.000
H28 Cataract and other disorders of lens in diseases classified elsewhere
0.575 0.425 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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