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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs115083581
log Bayes Factor = 14.4282
Chromosome 1   position 36,376,992  (GRCh37) Explore rs115083581 on Ensembl!
Variant rs115083581 is part of Cluster X0043

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
I20-I25 Ischaemic heart diseases
1.000 0.000 0.000
Chapter IX Diseases of the circulatory system
1.000 0.000 0.000
# Top node
1.000 0.000 0.000
M20-M25 Other joint disorders
1.000 0.000 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
1.000 0.000 0.000
I25 Chronic ischaemic heart disease
1.000 0.000 0.000
I20 Angina pectoris
0.999 0.001 0.000
M25 Other joint disorders, not elsewhere classified
0.999 0.001 0.000
I20.0 Unstable angina
0.997 0.003 0.000
M25.5 Pain in joint
0.994 0.006 0.000
M25.56 Pain in joint (Lower leg)
0.993 0.007 0.000
M20 Acquired deformities of fingers and toes
0.988 0.012 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
0.988 0.012 0.000
Chapter VII Diseases of the eye and adnexa
0.986 0.014 0.000
I30-I52 Other forms of heart disease
0.981 0.019 0.000
Chapter X Diseases of the respiratory system
0.979 0.021 0.000
I21 Acute myocardial infarction
0.971 0.029 0.000
I25.2 Old myocardial infarction
0.970 0.030 0.000
Chapter II Neoplasms
0.970 0.030 0.000
I20.9 Angina pectoris, unspecified
0.968 0.032 0.000
M15-M19 Arthrosis
0.967 0.033 0.000
T80-T88 Complications of surgical and medical care, not elsewhere classified
0.966 0.034 0.000
M17 Gonarthrosis [arthrosis of knee]
0.961 0.039 0.000
I25.1 Atherosclerotic heart disease
0.959 0.041 0.000
Chapter VIII Diseases of the ear and mastoid process
0.959 0.041 0.000
I51 Complications and ill-defined descriptions of heart disease
0.954 0.046 0.000
I25.8 Other forms of chronic ischaemic heart disease
0.948 0.052 0.000
J40-J47 Chronic lower respiratory diseases
0.945 0.055 0.000
M17.1 Other primary gonarthrosis
0.944 0.056 0.000
C76-C80 Malignant neoplasms of ill-defined, secondary and unspecified sites
0.937 0.063 0.000
T36-T50 Poisoning by drugs, medicaments and biological substances
0.936 0.064 0.000
M23 Internal derangement of knee
0.923 0.077 0.000
I21.9 Acute myocardial infarction, unspecified
0.920 0.080 0.000
M17.9 Gonarthrosis, unspecified
0.920 0.080 0.000
H25-H28 Disorders of lens
0.915 0.085 0.000
M20.1 Hallux valgus (acquired)
0.914 0.086 0.000
Chapter XXII Codes for special purposes
0.913 0.087 0.000
I25.9 Chronic ischaemic heart disease, unspecified
0.912 0.088 0.000
I24 Other acute ischaemic heart diseases
0.911 0.089 0.000
C79 Secondary malignant neoplasm of other sites
0.907 0.093 0.000
I49 Other cardiac arrhythmias
0.906 0.094 0.000
I70-I79 Diseases of arteries, arterioles and capillaries
0.905 0.095 0.000
M25.4 Effusion of joint
0.903 0.097 0.000
J44 Other chronic obstructive pulmonary disease
0.900 0.100 0.000
I51.8 Other ill-defined heart diseases
0.896 0.104 0.000
T81 Complications of procedures, not elsewhere classified
0.895 0.105 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.890 0.110 0.000
H90-H95 Other disorders of ear
0.878 0.122 0.000
M22 Disorders of patella
0.876 0.124 0.000
M20.5 Other deformities of toe(s) (acquired)
0.875 0.125 0.000
I31 Other diseases of pericardium
0.871 0.129 0.000
Chapter V Mental and behavioural disorders
0.871 0.129 0.000
M23.3 Other meniscus derangements
0.869 0.131 0.000
D00-D09 In situ neoplasms
0.867 0.133 0.000
I21.2 Acute transmural myocardial infarction of other sites
0.866 0.134 0.000
C15-C26 Malignant neoplasms of digestive organs
0.863 0.137 0.000
T83 Complications of genito-urinary prosthetic devices, implants and grafts
0.862 0.138 0.000
M20.0 Deformity of finger(s)
0.860 0.140 0.000
C30-C39 Malignant neoplasms of respiratory and intrathoracic organs
0.858 0.142 0.000
I51.7 Cardiomegaly
0.853 0.147 0.000
I34 Nonrheumatic mitral valve disorders
0.853 0.147 0.000
C79.5 Secondary malignant neoplasm of bone and bone marrow
0.850 0.150 0.000
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics
0.848 0.152 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.848 0.152 0.000
H25 Senile cataract
0.845 0.155 0.000
M25.8 Other specified joint disorders
0.840 0.160 0.000
I60-I69 Cerebrovascular diseases
0.836 0.164 0.000
D70-D77 Other diseases of blood and blood-forming organs
0.835 0.165 0.000
M25.46 Effusion of joint (Lower leg)
0.834 0.166 0.000
S10-S19 Injuries to the neck
0.834 0.166 0.000
I49.0 Ventricular fibrillation and flutter
0.833 0.167 0.000
J44.0 Chronic obstructive pulmonary disease with acute lower respiratory infection
0.833 0.167 0.000
J90-J94 Other diseases of pleura
0.832 0.168 0.000
I24.9 Acute ischaemic heart disease, unspecified
0.827 0.173 0.000
M70-M79 Other soft tissue disorders
0.826 0.174 0.000
J47 Bronchiectasis
0.826 0.174 0.000
M23.8 Other internal derangements of knee
0.823 0.177 0.000
M20.2 Hallux rigidus
0.823 0.177 0.000
H53-H54 Visual disturbances and blindness
0.820 0.180 0.000
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation
0.820 0.180 0.000
J95-J99 Other diseases of the respiratory system
0.816 0.184 0.000
H10-H13 Disorders of conjunctiva
0.813 0.187 0.000
J40 Bronchitis, not specified as acute or chronic
0.811 0.189 0.000
I47 Paroxysmal tachycardia
0.810 0.190 0.000
I78 Diseases of capillaries
0.809 0.191 0.000
H25.1 Senile nuclear cataract
0.809 0.191 0.000
M25.0 Haemarthrosis
0.808 0.192 0.000
I22 Subsequent myocardial infarction
0.803 0.197 0.000
H80-H83 Diseases of inner ear
0.802 0.198 0.000
T82 Complications of cardiac and vascular prosthetic devices, implants and grafts
0.801 0.199 0.000
U00-U49 Provisional assignment of new diseases of uncertain etiology or emergency use
0.793 0.207 0.000
D37-D48 Neoplasms of uncertain or unknown behaviour
0.791 0.208 0.000
H55-H59 Other disorders of eye and adnexa
0.791 0.208 0.000
C18 Malignant neoplasm of colon
0.791 0.209 0.000
F40-F48 Neurotic, stress-related and somatoform disorders
0.789 0.211 0.000
C78 Secondary malignant neoplasm of respiratory and digestive organs
0.787 0.213 0.000
M80-M85 Disorders of bone density and structure
0.787 0.213 0.000
J09-J18 Influenza and pneumonia
0.786 0.214 0.000
M31 Other necrotising vasculopathies
0.786 0.214 0.000
I71 Aortic aneurysm and dissection
0.785 0.215 0.000
T81.2 Accidental puncture and laceration during a procedure, not elsewhere classified
0.785 0.215 0.000
M23.33 Other meniscus derangements (Medial collateral ligament or Other and unspecified medial meniscus)
0.783 0.217 0.000
I34.0 Mitral (valve) insufficiency
0.781 0.219 0.000
M24 Other specific joint derangements
0.779 0.221 0.000
U82-U85 Resistance to antimicrobial and antineoplastic drugs
0.777 0.223 0.000
J44.8 Other specified chronic obstructive pulmonary disease
0.777 0.223 0.000
H46-H48 Disorders of optic nerve and visual pathways
0.775 0.225 0.000
T86 Failure and rejection of transplanted organs and tissues
0.774 0.226 0.000
I21.4 Acute subendocardial myocardial infarction
0.773 0.227 0.000
J60-J70 Lung diseases due to external agents
0.770 0.230 0.000
I49.3 Ventricular premature depolarisation
0.768 0.232 0.000
J85-J86 Suppurative and necrotic conditions of lower respiratory tract
0.767 0.233 0.000
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances
0.767 0.233 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.765 0.234 0.000
M86-M90 Other osteopathies
0.765 0.235 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.765 0.235 0.000
H30-H36 Disorders of choroid and retina
0.764 0.236 0.000
M25.50 Pain in joint (Multiple sites)
0.763 0.237 0.000
H91 Other hearing loss
0.763 0.237 0.000
T39.1 4-Aminophenol derivatives
0.762 0.238 0.000
C79.3 Secondary malignant neoplasm of brain and cerebral meninges
0.762 0.238 0.000
S80-S89 Injuries to the knee and lower leg
0.761 0.239 0.000
J44.1 Chronic obstructive pulmonary disease with acute exacerbation, unspecified
0.760 0.239 0.000
I25.5 Ischaemic cardiomyopathy
0.760 0.240 0.000
T88 Other complications of surgical and medical care, not elsewhere classified
0.757 0.243 0.000
M72 Fibroblastic disorders
0.756 0.244 0.000
C25 Malignant neoplasm of pancreas
0.755 0.245 0.000
H49-H52 Disorders of ocular muscles, binocular movement, accommodation and refraction
0.755 0.245 0.000
I64 Stroke, not specified as haemorrhage or infarction
0.754 0.246 0.000
I05-I09 Chronic rheumatic heart diseases
0.753 0.247 0.000
I46 Cardiac arrest
0.752 0.248 0.000
I31.9 Disease of pericardium, unspecified
0.751 0.248 0.000
H15-H22 Disorders of sclera, cornea, iris and ciliary body
0.751 0.249 0.000
H60-H62 Diseases of external ear
0.751 0.249 0.000
I63 Cerebral infarction
0.746 0.254 0.000
M20.6 Acquired deformity of toe(s), unspecified
0.746 0.254 0.000
T81.3 Disruption of operation wound, not elsewhere classified
0.742 0.258 0.000
I78.1 Naevus, nonneoplastic
0.740 0.260 0.000
I72 Other aneurysm
0.740 0.260 0.000
C18.2 Ascending colon
0.739 0.261 0.000
D70 Agranulocytosis
0.737 0.263 0.000
M22.4 Chondromalacia patellae
0.736 0.264 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.735 0.265 0.000
H65-H75 Diseases of middle ear and mastoid
0.734 0.266 0.000
H90 Conductive and sensorineural hearing loss
0.733 0.267 0.000
C34 Malignant neoplasm of bronchus and lung
0.729 0.271 0.000
I74 Arterial embolism and thrombosis
0.729 0.271 0.000
M22.8 Other disorders of patella
0.726 0.274 0.000
T81.9 Unspecified complication of procedure
0.726 0.274 0.000
I20.1 Angina pectoris with documented spasm
0.726 0.274 0.000
M25.54 Pain in joint (Hand)
0.725 0.275 0.000
C79.2 Secondary malignant neoplasm of skin
0.724 0.276 0.000
T82.8 Other complications of cardiac and vascular prosthetic devices, implants and grafts
0.724 0.276 0.000
H26 Other cataract
0.722 0.278 0.000
H95 Postprocedural disorders of ear and mastoid process, not elsewhere classified
0.720 0.280 0.000
M23.81 Other internal derangements of knee (Anterior cruciate ligament or Anterior horn of medial meniscus)
0.719 0.281 0.000
I24.8 Other forms of acute ischaemic heart disease
0.718 0.282 0.000
I49.8 Other specified cardiac arrhythmias
0.718 0.282 0.000
I51.9 Heart disease, unspecified
0.717 0.283 0.000
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]
0.717 0.283 0.000
I23 Certain current complications following acute myocardial infarction
0.717 0.283 0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.717 0.283 0.000
M34 Systemic sclerosis
0.717 0.283 0.000
M33 Dermatopolymyositis
0.717 0.283 0.000
M32 Systemic lupus erythematosus
0.717 0.283 0.000
M30 Polyarteritis nodosa and related conditions
0.717 0.283 0.000
M21 Other acquired deformities of limbs
0.717 0.283 0.000
I00-I02 Acute rheumatic fever
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
M91-M94 Chondropathies
0.717 0.283 0.000
M60-M63 Disorders of muscles
0.717 0.283 0.000
M00-M03 Infectious arthropathies
0.717 0.283 0.000
I25.6 Silent myocardial ischaemia
0.717 0.283 0.000
I25.4 Coronary artery aneurysm
0.717 0.283 0.000
I25.3 Aneurysm of heart
0.717 0.283 0.000
I25.0 Atherosclerotic cardiovascular disease, so described
0.717 0.283 0.000
I21.0 Acute transmural myocardial infarction of anterior wall
0.717 0.283 0.000
M25.9 Joint disorder, unspecified
0.716 0.284 0.000
M25.6 Stiffness of joint, not elsewhere classified
0.716 0.284 0.000
M25.3 Other instability of joint
0.716 0.284 0.000
M25.2 Flail joint
0.716 0.284 0.000
M25.1 Fistula of joint
0.716 0.284 0.000
T81.8 Other complications of procedures, not elsewhere classified
0.716 0.284 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.715 0.285 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.715 0.285 0.000
S90-S99 Injuries to the ankle and foot
0.712 0.287 0.000
M25.59 Pain in joint (Site unspecified)
0.712 0.287 0.000
M25.58 Pain in joint (Other)
0.712 0.287 0.000
M25.52 Pain in joint (Upper arm)
0.712 0.287 0.000
T83.0 Mechanical complication of urinary (indwelling) catheter
0.712 0.288 0.000
T43 Poisoning by psychotropic drugs, not elsewhere classified
0.711 0.289 0.000
H43-H45 Disorders of vitreous body and globe
0.711 0.289 0.000
I31.3 Pericardial effusion (noninflammatory)
0.709 0.291 0.000
F41 Other anxiety disorders
0.709 0.291 0.000
M20.3 Other deformity of hallux (acquired)
0.709 0.291 0.000
Q60-Q64 Congenital malformations of the urinary system
0.709 0.291 0.000
T33-T35 Frostbite
0.708 0.291 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.708 0.291 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.708 0.291 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.708 0.291 0.000
T00-T07 Injuries involving multiple body regions
0.708 0.291 0.000
C32 Malignant neoplasm of larynx
0.708 0.292 0.000
U80 Agent resistant to penicillin and related antibiotics
0.708 0.292 0.000
M72.0 Palmar fascial fibromatosis [Dupuytren]
0.706 0.294 0.000
T44 Poisoning by drugs primarily affecting the autonomic nervous system
0.706 0.294 0.000
M23.32 Other meniscus derangements (Posterior cruciate ligament or Posterior horn of medial meniscus)
0.706 0.294 0.000
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx
0.705 0.295 0.000
I52 Other heart disorders in diseases classified elsewhere
0.703 0.296 0.000
I48 Atrial fibrillation and flutter
0.703 0.296 0.000
I43 Cardiomyopathy in diseases classified elsewhere
0.703 0.296 0.000
I41 Myocarditis in diseases classified elsewhere
0.703 0.296 0.000
I40 Acute myocarditis
0.703 0.296 0.000
I39 Endocarditis and heart valve disorders in diseases classified elsewhere
0.703 0.296 0.000
I37 Pulmonary valve disorders
0.703 0.296 0.000
I36 Nonrheumatic tricuspid valve disorders
0.703 0.296 0.000
I33 Acute and subacute endocarditis
0.703 0.296 0.000
I32 Pericarditis in diseases classified elsewhere
0.703 0.296 0.000
I30 Acute pericarditis
0.703 0.296 0.000
Chapter XI Diseases of the digestive system
0.703 0.297 0.000
D06 Carcinoma in situ of cervix uteri
0.702 0.298 0.000
I27 Other pulmonary heart diseases
0.702 0.298 0.000
D02 Carcinoma in situ of middle ear and respiratory system
0.701 0.299 0.000
M23.34 Other meniscus derangements (Lateral collateral ligament or Anterior horn of lateral meniscus)
0.700 0.300 0.000
C45-C49 Malignant neoplasms of mesothelial and soft tissue
0.700 0.300 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.700 0.300 0.000
F20-F29 Schizophrenia, schizotypal and delusional disorders
0.699 0.301 0.000
H40-H42 Glaucoma
0.699 0.301 0.000
J98 Other respiratory disorders
0.698 0.302 0.000
D80-D89 Certain disorders involving the immune mechanism
0.698 0.302 0.000
T79-T79 Certain early complications of trauma
0.697 0.303 0.000
C69-C72 Malignant neoplasms of eye, brain and other parts of central nervous system
0.697 0.303 0.000
T81.4 Infection following a procedure, not elsewhere classified
0.697 0.303 0.000
I21.X Presumed acute myicardial infaction (unconfirmed)
0.696 0.304 0.000
I21.3 Acute transmural myocardial infarction of unspecified site
0.696 0.304 0.000
C97-C97 Malignant neoplasms of independent (primary) multiple sites
0.695 0.305 0.000
C40-C41 Malignant neoplasms of bone and articular cartilage
0.695 0.305 0.000
S10 Superficial injury of neck
0.694 0.305 0.000
M15 Polyarthrosis
0.693 0.307 0.000
T87 Complications peculiar to reattachment and amputation
0.692 0.307 0.000
T80 Complications following infusion, transfusion and therapeutic injection
0.692 0.307 0.000
D72 Other disorders of white blood cells
0.692 0.308 0.000
T83.3 Mechanical complication of intra-uterine contraceptive device
0.692 0.308 0.000
M17.5 Other secondary gonarthrosis
0.689 0.311 0.000
M17.4 Other secondary gonarthrosis, bilateral
0.689 0.311 0.000
M17.3 Other posttraumatic gonarthrosis
0.689 0.311 0.000
M17.2 Posttraumatic gonarthrosis, bilateral
0.689 0.311 0.000
T83.1 Mechanical complication of other urinary devices and implants
0.689 0.311 0.000
H11 Other disorders of conjunctiva
0.688 0.312 0.000
I51.6 Cardiovascular disease, unspecified
0.684 0.316 0.000
I51.5 Myocardial degeneration
0.684 0.316 0.000
I51.4 Myocarditis, unspecified
0.684 0.316 0.000
I51.3 Intracardiac thrombosis, not elsewhere classified
0.684 0.316 0.000
I51.2 Rupture of papillary muscle, not elsewhere classified
0.684 0.316 0.000
I51.1 Rupture of chordae tendineae, not elsewhere classified
0.684 0.316 0.000
I51.0 Cardiac septal defect, acquired
0.684 0.316 0.000
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue
0.683 0.316 0.000
S40-S49 Injuries to the shoulder and upper arm
0.683 0.317 0.000
M23.36 Other meniscus derangements (Other and unspecified lateral meniscus)
0.681 0.319 0.000
H91.9 Hearing loss, unspecified
0.680 0.320 0.000
I47.1 Supraventricular tachycardia
0.679 0.321 0.000
J41 Simple and mucopurulent chronic bronchitis
0.677 0.323 0.000
J46 Status asthmaticus
0.677 0.323 0.000
M25.85 Other specified joint disorders (Pelvic region and thigh)
0.677 0.323 0.000
I49.4 Other and unspecified premature depolarisation
0.677 0.323 0.000
J90 Pleural effusion, not elsewhere classified
0.676 0.324 0.000
D03 Melanoma in situ
0.675 0.325 0.000
M65-M68 Disorders of synovium and tendon
0.675 0.325 0.000
M25.86 Other specified joint disorders (Lower leg)
0.674 0.325 0.000
J20-J22 Other acute lower respiratory infections
0.674 0.326 0.000
J42 Unspecified chronic bronchitis
0.674 0.326 0.000
T39.3 Other nonsteroidal anti-inflammatory drugs [NSAID]
0.673 0.327 0.000
C76 Malignant neoplasm of other and ill-defined sites
0.672 0.328 0.000
M25.06 Haemarthrosis (Lower leg)
0.671 0.329 0.000
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs
0.671 0.329 0.000
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system
0.671 0.329 0.000
T47 Poisoning by agents primarily affecting gastro-intestinal system
0.671 0.329 0.000
T46 Poisoning by agents primarily affecting the cardiovascular system
0.671 0.329 0.000
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified
0.671 0.329 0.000
T41 Poisoning by anaesthetics and therapeutic gases
0.671 0.329 0.000
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.671 0.329 0.000
T37 Poisoning by other systemic anti-infectives and antiparasitics
0.671 0.329 0.000
T36 Poisoning by systemic antibiotics
0.671 0.329 0.000
M72.04 Palmar fascial fibromatosis [Dupuytren]-Hand
0.671 0.329 0.000
H25.0 Senile incipient cataract
0.670 0.330 0.000
T85 Complications of other internal prosthetic devices, implants and grafts
0.669 0.331 0.000
C79.8 Secondary malignant neoplasm of other specified sites
0.668 0.332 0.000
H35 Other retinal disorders
0.667 0.333 0.000
M45-M49 Spondylopathies
0.666 0.334 0.000
M23.4 Loose body in knee
0.666 0.334 0.000
S20-S29 Injuries to the thorax
0.666 0.334 0.000
S82 Fracture of lower leg, including ankle
0.666 0.334 0.000
M77 Other enthesopathies
0.665 0.335 0.000
M23.89 Other internal derangements of knee (Unspecified ligament or Unspecified meniscus)
0.663 0.337 0.000
I63.5 Cerebral infarction due to unspecified occlusion or stenosis of cerebral arteries
0.663 0.337 0.000
H26.4 After-cataract
0.663 0.337 0.000
I47.0 Reentry ventricular arrhythmia
0.662 0.338 0.000
M23.9 Internal derangement of knee, unspecified
0.662 0.338 0.000
M23.6 Other spontaneous disruption of ligament(s) of knee
0.662 0.338 0.000
M23.5 Chronic instability of knee
0.662 0.338 0.000
M23.1 Discoid meniscus (congenital)
0.662 0.338 0.000
M23.0 Cystic meniscus
0.662 0.338 0.000
I22.9 Subsequent myocardial infarction of unspecified site
0.662 0.338 0.000
M25.53 Pain in joint (Forearm)
0.661 0.339 0.000
C51-C58 Malignant neoplasms of female genital organs
0.660 0.340 0.000
C19 Malignant neoplasm of rectosigmoid junction
0.658 0.342 0.000
C80 Malignant neoplasm without specification of site
0.658 0.342 0.000
C78.7 Secondary malignant neoplasm of liver
0.658 0.342 0.000
M20.4 Other hammer toe(s) (acquired)
0.657 0.343 0.000
H53 Visual disturbances
0.657 0.343 0.000
C25.9 Pancreas, unspecified
0.657 0.343 0.000
H28 Cataract and other disorders of lens in diseases classified elsewhere
0.656 0.344 0.000
H27 Other disorders of lens
0.656 0.344 0.000
M25.51 Pain in joint (Shoulder region)
0.655 0.344 0.000
K70-K77 Diseases of liver
0.655 0.345 0.000
F60-F69 Disorders of adult personality and behaviour
0.654 0.346 0.000
I24.1 Dressler's syndrome
0.653 0.346 0.000
I24.0 Coronary thrombosis not resulting in myocardial infarction
0.653 0.346 0.000
D73 Diseases of spleen
0.653 0.347 0.000
D47 Other neoplasms of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue
0.653 0.347 0.000
M25.55 Pain in joint (Pelvic region and thigh)
0.653 0.347 0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.652 0.348 0.000
C73-C75 Malignant neoplasms of thyroid and other endocrine glands
0.652 0.348 0.000
C79.9 Secondary malignant neoplasm, unspecified site
0.650 0.349 0.000
C79.7 Secondary malignant neoplasm of adrenal gland
0.650 0.349 0.000
C79.6 Secondary malignant neoplasm of ovary
0.650 0.349 0.000
C79.4 Secondary malignant neoplasm of other and unspecified parts of nervous system
0.650 0.349 0.000
C79.1 Secondary malignant neoplasm of bladder and other and unspecified urinary organs
0.650 0.349 0.000
C79.0 Secondary malignant neoplasm of kidney and renal pelvis
0.650 0.349 0.000
H54 Blindness and low vision
0.650 0.350 0.000
S70-S79 Injuries to the hip and thigh
0.650 0.350 0.000
I49.2 Junctional premature depolarisation
0.649 0.351 0.000
I49.1 Atrial premature depolarisation
0.649 0.351 0.000
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.649 0.351 0.000
I70 Atherosclerosis
0.649 0.351 0.000
J98.1 Pulmonary collapse
0.648 0.352 0.000
S12 Fracture of neck
0.648 0.352 0.000
C18.6 Descending colon
0.648 0.352 0.000
M25.49 Effusion of joint (Site unspecified)
0.647 0.352 0.000
M25.48 Effusion of joint (Other)
0.647 0.352 0.000
M25.47 Effusion of joint (Ankle and foot)
0.647 0.352 0.000
M25.45 Effusion of joint (Pelvic region and thigh)
0.647 0.352 0.000
M25.44 Effusion of joint (Hand)
0.647 0.352 0.000
M25.43 Effusion of joint (Forearm)
0.647 0.352 0.000
M25.42 Effusion of joint (Upper arm)
0.647 0.352 0.000
M25.41 Effusion of joint (Shoulder region)
0.647 0.352 0.000
M25.40 Effusion of joint (Multiple sites)
0.647 0.352 0.000
J91 Pleural effusion in conditions classified elsewhere
0.647 0.353 0.000
T50.9 Other and unspecified drugs, medicaments and biological substances
0.646 0.354 0.000
H83 Other diseases of inner ear
0.646 0.354 0.000
D04 Carcinoma in situ of skin
0.645 0.354 0.000
Q20-Q28 Congenital malformations of the circulatory system
0.645 0.355 0.000
M25.7 Osteophyte
0.644 0.356 0.000
J13 Pneumonia due to Streptococcus pneumoniae
0.644 0.356 0.000
C64-C68 Malignant neoplasms of urinary tract
0.644 0.356 0.000
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs
0.643 0.357 0.000
D45 Polycythaemia vera
0.643 0.357 0.000
H00-H06 Disorders of eyelid, lacrimal system and orbit
0.642 0.358 0.000
K50-K52 Noninfective enteritis and colitis
0.642 0.358 0.000
T81.7 Vascular complications following a procedure, not elsewhere classified
0.641 0.358 0.000
T81.6 Acute reaction to foreign substance accidentally left during a procedure
0.641 0.358 0.000
T81.5 Foreign body accidentally left in body cavity or operation wound following a procedure
0.641 0.358 0.000
T81.1 Shock during or resulting from a procedure, not elsewhere classified
0.641 0.358 0.000
U89 Agent resistant to other and unspecified antibiotics
0.640 0.360 0.000
F99-F99 Unspecified mental disorder
0.640 0.360 0.000
D07 Carcinoma in situ of other and unspecified genital organs
0.639 0.361 0.000
D55-D59 Haemolytic anaemias
0.638 0.362 0.000
D48 Neoplasm of uncertain or unknown behaviour of other and unspecified sites
0.637 0.363 0.000
T66-T78 Other and unspecified effects of external causes
0.634 0.365 0.000
H55 Nystagmus and other irregular eye movements
0.634 0.366 0.000
C78.8 Secondary malignant neoplasm of other and unspecified digestive organs
0.633 0.367 0.000
M50-M54 Other dorsopathies
0.633 0.367 0.000
M31.6 Other giant cell arteritis
0.633 0.367 0.000
I71.3 Abdominal aortic aneurysm, ruptured
0.631 0.368 0.000
D75 Other diseases of blood and blood-forming organs
0.630 0.370 0.000
H94 Other disorders of ear in diseases classified elsewhere
0.630 0.370 0.000
I95-I99 Other and unspecified disorders of the circulatory system
0.630 0.370 0.000
M18 Arthrosis of first carpometacarpal joint
0.629 0.371 0.000
C43-C44 Melanoma and other malignant neoplasms of skin
0.629 0.371 0.000
M22.1 Recurrent subluxation of patella
0.628 0.372 0.000
M22.9 Disorder of patella, unspecified
0.628 0.372 0.000
M22.3 Other derangements of patella
0.628 0.372 0.000
M22.0 Recurrent dislocation of patella
0.628 0.372 0.000
J92 Pleural plaque
0.628 0.372 0.000
J43 Emphysema
0.626 0.374 0.000
I31.8 Other specified diseases of pericardium
0.625 0.375 0.000
I31.2 Haemopericardium, not elsewhere classified
0.625 0.375 0.000
I31.1 Chronic constrictive pericarditis
0.625 0.375 0.000
I31.0 Chronic adhesive pericarditis
0.625 0.375 0.000
Q38-Q45 Other congenital malformations of the digestive system
0.625 0.375 0.000
F90-F98 Behavioural and emotional disorders with onset usually occurring in childhood and adolescence
0.624 0.376 0.000
F80-F89 Disorders of psychological development
0.624 0.376 0.000
F70-F79 Mental retardation
0.624 0.376 0.000
F50-F59 Behavioural syndromes associated with physiological disturbances and physical factors
0.624 0.376 0.000
I46.0 Cardiac arrest with successful resuscitation
0.624 0.376 0.000
H46 Optic neuritis
0.624 0.376 0.000
M23.39 Other meniscus derangements (Unspecified ligament or Unspecified meniscus)
0.623 0.377 0.000
M23.37 Other meniscus derangements-Capsular lig
0.623 0.377 0.000
M23.35 Other meniscus derangements (Posterior horn of lateral meniscus)
0.623 0.377 0.000
M23.31 Other meniscus derangements (Anterior cruciate ligament or Anterior horn of medial meniscus)
0.623 0.377 0.000
S39 Other and unspecified injuries of abdomen, lower back and pelvis
0.623 0.377 0.000
I71.4 Abdominal aortic aneurysm, without mention of rupture
0.622 0.378 0.000
D09 Carcinoma in situ of other and unspecified sites
0.621 0.379 0.000
D01 Carcinoma in situ of other and unspecified digestive organs
0.621 0.379 0.000
D00 Carcinoma in situ of oral cavity, oesophagus and stomach
0.621 0.379 0.000
I72.4 Aneurysm of artery of lower extremity
0.621 0.379 0.000
U88 Agent resistant to multiple antibiotics
0.621 0.379 0.000
U80.8 Agent resistant to other penicillin-related antibiotic
0.621 0.379 0.000
H80 Otosclerosis
0.621 0.379 0.000
M24.1 Other articular cartilage disorders
0.620 0.379 0.000
M80 Osteoporosis with pathological fracture
0.620 0.379 0.000
H52 Disorders of refraction and accommodation
0.619 0.381 0.000
C26 Malignant neoplasm of other and ill-defined digestive organs
0.619 0.381 0.000
C24 Malignant neoplasm of other and unspecified parts of biliary tract
0.619 0.381 0.000
C22 Malignant neoplasm of liver and intrahepatic bile ducts
0.619 0.381 0.000
C21 Malignant neoplasm of anus and anal canal
0.619 0.381 0.000
C17 Malignant neoplasm of small intestine
0.619 0.381 0.000
C23 Malignant neoplasm of gallbladder
0.619 0.381 0.000
T83.9 Unspecified complication of genito-urinary prosthetic device, implant and graft
0.618 0.382 0.000
T83.8 Other complications of genito-urinary prosthetic devices, implants and grafts
0.618 0.382 0.000
T83.6 Infection and inflammatory reaction due to prosthetic device, implant and graft in genital tract
0.618 0.382 0.000
T83.5 Infection and inflammatory reaction due to prosthetic device, implant and graft in urinary system
0.618 0.382 0.000
T83.4 Mechanical complication of other prosthetic devices, implants and grafts in genital tract
0.618 0.382 0.000
T83.2 Mechanical complication of graft of urinary organ
0.618 0.382 0.000
T86.1 Kidney transplant failure and rejection
0.617 0.383 0.000
D05 Carcinoma in situ of breast
0.617 0.383 0.000
J61 Pneumoconiosis due to asbestos and other mineral fibres
0.616 0.384 0.000
C34.3 Lower lobe, bronchus or lung
0.616 0.384 0.000
J86 Pyothorax
0.615 0.385 0.000
C39 Malignant neoplasm of other and ill-defined sites in the respiratory system and intrathoracic organs
0.615 0.385 0.000
C38 Malignant neoplasm of heart, mediastinum and pleura
0.615 0.385 0.000
C31 Malignant neoplasm of accessory sinuses
0.615 0.385 0.000
C30 Malignant neoplasm of nasal cavity and middle ear
0.615 0.385 0.000
C37 Malignant neoplasm of thymus
0.615 0.385 0.000
C33 Malignant neoplasm of trachea
0.615 0.385 0.000
M22.2 Patellofemoral disorders
0.615 0.385 0.000
F43 Reaction to severe stress, and adjustment disorders
0.615 0.385 0.000
C78.0 Secondary malignant neoplasm of lung
0.615 0.385 0.000
J15 Bacterial pneumonia, not elsewhere classified
0.613 0.387 0.000
I34.9 Nonrheumatic mitral valve disorder, unspecified
0.611 0.388 0.000
I34.8 Other nonrheumatic mitral valve disorders
0.611 0.388 0.000
I34.2 Nonrheumatic mitral (valve) stenosis
0.611 0.388 0.000
K50 Crohn's disease [regional enteritis]
0.610 0.390 0.000
M79 Other soft tissue disorders, not elsewhere classified
0.610 0.390 0.000
T40.6 Other and unspecified narcotics
0.609 0.391 0.000
Q61 Cystic kidney disease
0.609 0.391 0.000
T39.9 Nonopioid analgesic, antipyretic and antirheumatic, unspecified
0.608 0.392 0.000
T39.8 Other nonopioid analgesics and antipyretics, not elsewhere classified
0.608 0.392 0.000
T39.4 Antirheumatics, not elsewhere classified
0.608 0.392 0.000
T39.2 Pyrazolone derivatives
0.608 0.392 0.000
T39.0 Salicylates
0.608 0.392 0.000
Q90-Q99 Chromosomal abnormalities, not elsewhere classified
0.608 0.392 0.000
Q80-Q89 Other congenital malformations
0.608 0.392 0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.608 0.392 0.000
Q50-Q56 Congenital malformations of genital organs
0.608 0.392 0.000
Q35-Q37 Cleft lip and cleft palate
0.608 0.392 0.000
Q30-Q34 Congenital malformations of the respiratory system
0.608 0.392 0.000
Q10-Q18 Congenital malformations of eye, ear, face and neck
0.608 0.392 0.000
Q00-Q07 Congenital malformations of the nervous system
0.608 0.392 0.000
I27.2 Other secondary pulmonary hypertension
0.608 0.392 0.000
I60 Subarachnoid haemorrhage
0.607 0.392 0.000
S50-S59 Injuries to the elbow and forearm
0.607 0.393 0.000
I74.8 Embolism and thrombosis of other arteries
0.607 0.393 0.000
H25.2 Senile cataract, morgagnian type
0.606 0.394 0.000
I42 Cardiomyopathy
0.606 0.394 0.000
H95.1 Other disorders following mastoidectomy
0.606 0.394 0.000
F45 Somatoform disorders
0.605 0.395 0.000
J30-J39 Other diseases of upper respiratory tract
0.603 0.397 0.000
M25.89 Other specified joint disorders (Site unspecified)
0.602 0.398 0.000
M25.88 Other specified joint disorders (Other)
0.602 0.398 0.000
M25.87 Other specified joint disorders (Ankle and foot)
0.602 0.398 0.000
M25.84 Other specified joint disorders (Hand)
0.602 0.398 0.000
M25.83 Other specified joint disorders (Forearm)
0.602 0.398 0.000
M25.82 Other specified joint disorders (Upper arm)
0.602 0.398 0.000
M25.81 Other specified joint disorders (Shoulder region)
0.602 0.398 0.000
M25.80 Other specified joint disorders (Multiple sites)
0.602 0.398 0.000
I49.5 Sick sinus syndrome
0.602 0.398 0.000
T82.5 Mechanical complication of other cardiac and vascular devices and implants
0.602 0.398 0.000
J93 Pneumothorax
0.602 0.398 0.000
M70 Soft tissue disorders related to use, overuse and pressure
0.601 0.399 0.000
C32.9 Larynx, unspecified
0.601 0.399 0.000
M40-M43 Deforming dorsopathies
0.600 0.400 0.000
H90.1 Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side
0.599 0.400 0.000
I68 Cerebrovascular disorders in diseases classified elsewhere
0.599 0.401 0.000
I66 Occlusion and stenosis of cerebral arteries, not resulting in cerebral infarction
0.599 0.401 0.000
I62 Other nontraumatic intracranial haemorrhage
0.599 0.401 0.000
D76 Certain diseases involving lymphoreticular tissue and reticulohistiocytic system
0.599 0.401 0.000
D74 Methaemoglobinaemia
0.599 0.401 0.000
D77 Other disorders of blood and blood-forming organs in diseases classified elsewhere
0.599 0.401 0.000
D71 Functional disorders of polymorphonuclear neutrophils
0.599 0.401 0.000
M84 Disorders of continuity of bone
0.598 0.402 0.000
S19 Other and unspecified injuries of neck
0.598 0.402 0.000
S17 Crushing injury of neck
0.598 0.402 0.000
S15 Injury of blood vessels at neck level
0.598 0.402 0.000
S14 Injury of nerves and spinal cord at neck level
0.598 0.402 0.000
S13 Dislocation, sprain and strain of joints and ligaments at neck level
0.598 0.402 0.000
S11 Open wound of neck
0.598 0.402 0.000
S18 Traumatic amputation at neck level
0.598 0.402 0.000
S16 Injury of muscle and tendon at neck level
0.598 0.402 0.000
H81 Disorders of vestibular function
0.597 0.402 0.000
J94 Other pleural conditions
0.597 0.403 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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