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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs116111989
log Bayes Factor = 16.0247
Chromosome 4   position 189,767,112  (GRCh37) Explore rs116111989 on Ensembl!
Variant rs116111989 is part of Cluster X0123

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
Chapter XIX Injury, poisoning and certain other consequences of external causes
1.000 0.000 0.000
# Top node
1.000 0.000 0.000
Chapter IX Diseases of the circulatory system
1.000 0.000 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
1.000 0.000 0.000
Chapter VII Diseases of the eye and adnexa
1.000 0.000 0.000
Chapter V Mental and behavioural disorders
0.998 0.002 0.000
E10-E14 Diabetes mellitus
0.998 0.002 0.000
S80-S89 Injuries to the knee and lower leg
0.998 0.002 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.997 0.003 0.000
S00-S09 Injuries to the head
0.997 0.003 0.000
D50-D53 Nutritional anaemias
0.996 0.004 0.000
I70-I79 Diseases of arteries, arterioles and capillaries
0.995 0.005 0.000
D50 Iron deficiency anaemia
0.992 0.008 0.000
Chapter XX External causes of morbidity and mortality
0.991 0.009 0.000
D50.9 Iron deficiency anaemia, unspecified
0.986 0.014 0.000
E10 Insulin-dependent diabetes mellitus
0.985 0.015 0.000
H30-H36 Disorders of choroid and retina
0.984 0.016 0.000
H35 Other retinal disorders
0.977 0.023 0.000
I10-I15 Hypertensive diseases
0.975 0.025 0.000
S01 Open wound of head
0.973 0.027 0.000
E00-E07 Disorders of thyroid gland
0.973 0.027 0.000
H53-H54 Visual disturbances and blindness
0.966 0.034 0.000
E10.9 Without complications
0.966 0.034 0.000
E03 Other hypothyroidism
0.965 0.035 0.000
E11 Non-insulin-dependent diabetes mellitus
0.962 0.038 0.000
H15-H22 Disorders of sclera, cornea, iris and ciliary body
0.962 0.038 0.000
E03.9 Hypothyroidism, unspecified
0.959 0.041 0.000
S82 Fracture of lower leg, including ankle
0.959 0.041 0.000
S50-S59 Injuries to the elbow and forearm
0.959 0.041 0.000
I10 Essential (primary) hypertension
0.957 0.043 0.000
H35.3 Degeneration of macula and posterior pole
0.956 0.044 0.000
F30-F39 Mood [affective] disorders
0.955 0.045 0.000
F10-F19 Mental and behavioural disorders due to psychoactive substance use
0.955 0.045 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.954 0.046 0.000
T36-T50 Poisoning by drugs, medicaments and biological substances
0.951 0.049 0.000
S82.8 Fractures of other parts of lower leg
0.945 0.055 0.000
D51 Vitamin B12 deficiency anaemia
0.940 0.060 0.000
S60-S69 Injuries to the wrist and hand
0.939 0.061 0.000
I60-I69 Cerebrovascular diseases
0.938 0.062 0.000
I73 Other peripheral vascular diseases
0.936 0.064 0.000
H53 Visual disturbances
0.929 0.071 0.000
S82.80 Fractures of other parts of lower leg (closed)
0.927 0.073 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.925 0.075 0.000
I73.9 Peripheral vascular disease, unspecified
0.919 0.081 0.000
F33 Recurrent depressive disorder
0.918 0.082 0.000
E20-E35 Disorders of other endocrine glands
0.915 0.085 0.000
S00 Superficial injury of head
0.915 0.085 0.000
I71 Aortic aneurysm and dissection
0.908 0.092 0.000
I74 Arterial embolism and thrombosis
0.903 0.097 0.000
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation
0.898 0.102 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.896 0.104 0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.894 0.106 0.000
D51.0 Vitamin B12 deficiency anaemia due to intrinsic factor deficiency
0.893 0.107 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.893 0.107 0.000
V10-V19 Pedal cyclist injured in transport accident
0.892 0.108 0.000
E11.3 With ophthalmic complications
0.878 0.122 0.000
H18 Other disorders of cornea
0.878 0.122 0.000
H25-H28 Disorders of lens
0.877 0.123 0.000
I80-I89 Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified
0.875 0.125 0.000
S01.2 Open wound of nose
0.874 0.126 0.000
H35.0 Background retinopathy and retinal vascular changes
0.872 0.128 0.000
F17 Mental and behavioural disorders due to use of tobacco
0.871 0.129 0.000
H53.4 Visual field defects
0.871 0.129 0.000
W00-W19 Falls
0.869 0.131 0.000
F33.9 Recurrent depressive disorder, unspecified
0.865 0.135 0.000
S86 Injury of muscle and tendon at lower leg level
0.863 0.137 0.000
T90 Sequelae of injuries of head
0.857 0.143 0.000
H35.8 Other specified retinal disorders
0.857 0.143 0.000
H21 Other disorders of iris and ciliary body
0.856 0.144 0.000
F10 Mental and behavioural disorders due to use of alcohol
0.855 0.145 0.000
H43-H45 Disorders of vitreous body and globe
0.852 0.148 0.000
I95-I99 Other and unspecified disorders of the circulatory system
0.852 0.148 0.000
S81 Open wound of lower leg
0.851 0.149 0.000
S89 Other and unspecified injuries of lower leg
0.851 0.149 0.000
E11.9 Without complications
0.851 0.149 0.000
T79-T79 Certain early complications of trauma
0.850 0.150 0.000
S01.9 Open wound of head, part unspecified
0.848 0.152 0.000
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs
0.846 0.154 0.000
I05-I09 Chronic rheumatic heart diseases
0.845 0.155 0.000
S52 Fracture of forearm
0.845 0.155 0.000
S51 Open wound of forearm
0.842 0.158 0.000
H36 Retinal disorders in diseases classified elsewhere
0.841 0.159 0.000
D50.8 Other iron deficiency anaemias
0.840 0.160 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.840 0.160 0.000
S82.5 Fracture of medial malleolus
0.840 0.160 0.000
S01.0 Open wound of scalp
0.837 0.163 0.000
S10-S19 Injuries to the neck
0.837 0.163 0.000
F20-F29 Schizophrenia, schizotypal and delusional disorders
0.836 0.164 0.000
I63 Cerebral infarction
0.836 0.164 0.000
S80 Superficial injury of lower leg
0.835 0.165 0.000
H55-H59 Other disorders of eye and adnexa
0.833 0.167 0.000
F00-F09 Organic, including symptomatic, mental disorders
0.832 0.168 0.000
S70-S79 Injuries to the hip and thigh
0.830 0.170 0.000
E10.3 With ophthalmic complications
0.822 0.178 0.000
E16 Other disorders of pancreatic internal secretion
0.822 0.178 0.000
V18 Pedal cyclist injured in noncollision transport accident
0.821 0.179 0.000
S83 Dislocation, sprain and strain of joints and ligaments of knee
0.821 0.179 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.819 0.181 0.000
Y42 Hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.819 0.181 0.000
I74.3 Embolism and thrombosis of arteries of the lower extremities
0.818 0.182 0.000
S02 Fracture of skull and facial bones
0.816 0.184 0.000
S09 Other and unspecified injuries of head
0.815 0.185 0.000
S90-S99 Injuries to the ankle and foot
0.815 0.185 0.000
Y52 Agents primarily affecting the cardiovascular system
0.814 0.186 0.000
S66 Injury of muscle and tendon at wrist and hand level
0.813 0.187 0.000
I70 Atherosclerosis
0.809 0.191 0.000
F99-F99 Unspecified mental disorder
0.803 0.197 0.000
S00.8 Superficial injury of other parts of head
0.802 0.198 0.000
I26 Pulmonary embolism
0.801 0.199 0.000
S50 Superficial injury of forearm
0.798 0.201 0.000
D68 Other coagulation defects
0.798 0.202 0.000
H53.1 Subjective visual disturbances
0.796 0.204 0.000
F60-F69 Disorders of adult personality and behaviour
0.791 0.209 0.000
S82.81 Fractures of other parts of lower leg (open)
0.790 0.210 0.000
S60 Superficial injury of wrist and hand
0.790 0.210 0.000
F31 Bipolar affective disorder
0.789 0.211 0.000
I62 Other nontraumatic intracranial haemorrhage
0.788 0.212 0.000
S62 Fracture at wrist and hand level
0.787 0.213 0.000
S01.3 Open wound of ear
0.786 0.214 0.000
H54 Blindness and low vision
0.786 0.214 0.000
I85 Oesophageal varices
0.785 0.215 0.000
V18.0 Driver injured in nontraffic accident
0.784 0.216 0.000
W50-W64 Exposure to animate mechanical forces
0.782 0.218 0.000
Y51 Drugs primarily affecting the autonomic nervous system
0.781 0.219 0.000
I11 Hypertensive heart disease
0.781 0.219 0.000
F10.0 Acute intoxication
0.780 0.220 0.000
I71.4 Abdominal aortic aneurysm, without mention of rupture
0.777 0.223 0.000
S05 Injury of eye and orbit
0.776 0.224 0.000
E11.0 With coma
0.776 0.224 0.000
E11.8 With unspecified complications
0.775 0.225 0.000
I72 Other aneurysm
0.775 0.225 0.000
Y45 Analgesics, antipyretics and anti-inflammatory drugs
0.773 0.227 0.000
H18.5 Hereditary corneal dystrophies
0.772 0.228 0.000
W18 Other fall on same level
0.772 0.228 0.000
I82 Other venous embolism and thrombosis
0.771 0.229 0.000
I69 Sequelae of cerebrovascular disease
0.771 0.229 0.000
S01.5 Open wound of lip and oral cavity
0.771 0.229 0.000
X60-X84 Intentional self-harm
0.770 0.230 0.000
T42.6 Other antiepileptic and sedative-hypnotic drugs
0.769 0.231 0.000
E16.2 Hypoglycaemia, unspecified
0.769 0.231 0.000
T43 Poisoning by psychotropic drugs, not elsewhere classified
0.763 0.237 0.000
E22 Hyperfunction of pituitary gland
0.763 0.237 0.000
E13 Other specified diabetes mellitus
0.760 0.240 0.000
X20-X29 Contact with venomous animals and plants
0.759 0.241 0.000
S00.2 Other superficial injuries of eyelid and periocular area
0.759 0.241 0.000
H26 Other cataract
0.759 0.241 0.000
S01.7 Multiple open wounds of head
0.758 0.242 0.000
I89 Other non-infective disorders of lymphatic vessels and lymph nodes
0.757 0.243 0.000
F80-F89 Disorders of psychological development
0.757 0.243 0.000
E23 Hypofunction and other disorders of pituitary gland
0.756 0.244 0.000
S82.50 Fracture of medial malleolus (closed)
0.754 0.246 0.000
S01.1 Open wound of eyelid and periocular area
0.753 0.247 0.000
T90.2 Sequelae of fracture of skull and facial bones
0.753 0.247 0.000
F22 Persistent delusional disorders
0.751 0.249 0.000
I78 Diseases of capillaries
0.751 0.249 0.000
F17.1 Harmful use
0.751 0.249 0.000
I60 Subarachnoid haemorrhage
0.749 0.251 0.000
X40-X49 Accidental poisoning by and exposure to noxious substances
0.748 0.252 0.000
H21.8 Other specified disorders of iris and ciliary body
0.748 0.252 0.000
F17.2 Dependence syndrome
0.747 0.253 0.000
E10.4 With neurological complications
0.747 0.253 0.000
S89.9 Unspecified injury of lower leg
0.745 0.255 0.000
Y46 Antiepileptics and anti-Parkinsonism drugs
0.745 0.255 0.000
F34 Persistent mood [affective] disorders
0.744 0.256 0.000
T79 Certain early complications of trauma, not elsewhere classified
0.743 0.257 0.000
D50.0 Iron deficiency anaemia secondary to blood loss (chronic)
0.743 0.257 0.000
I71.2 Thoracic aortic aneurysm, without mention of rupture
0.742 0.258 0.000
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified
0.742 0.258 0.000
I74.8 Embolism and thrombosis of other arteries
0.741 0.259 0.000
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.741 0.259 0.000
Y57 Other and unspecified drugs and medicaments
0.738 0.262 0.000
H36.0 Diabetic retinopathy
0.738 0.262 0.000
F10.3 Withdrawal state
0.738 0.262 0.000
F33.2 Recurrent depressive disorder, current episode severe without psychotic symptoms
0.737 0.263 0.000
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics
0.736 0.264 0.000
I98 Other disorders of circulatory system in diseases classified elsewhere
0.733 0.267 0.000
I26.9 Pulmonary embolism without mention of acute cor pulmonale
0.732 0.268 0.000
I87 Other disorders of veins
0.732 0.268 0.000
T44 Poisoning by drugs primarily affecting the autonomic nervous system
0.731 0.269 0.000
Y41 Other systemic anti-infectives and antiparasitics
0.731 0.269 0.000
S61 Open wound of wrist and hand
0.730 0.270 0.000
S00.9 Superficial injury of head, part unspecified
0.730 0.270 0.000
F33.1 Recurrent depressive disorder, current episode moderate
0.729 0.271 0.000
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.728 0.272 0.000
S52.6 Fracture of lower end of both ulna and radius
0.728 0.272 0.000
T93 Sequelae of injuries of lower limb
0.727 0.273 0.000
Q20-Q28 Congenital malformations of the circulatory system
0.727 0.273 0.000
I15 Secondary hypertension
0.727 0.273 0.000
E06 Thyroiditis
0.726 0.274 0.000
E10.1 With ketoacidosis
0.725 0.275 0.000
T14 Injury of unspecified body region
0.725 0.275 0.000
S19 Other and unspecified injuries of neck
0.724 0.276 0.000
H18.4 Corneal degeneration
0.724 0.276 0.000
Chapter X Diseases of the respiratory system
0.724 0.276 0.000
F50-F59 Behavioural syndromes associated with physiological disturbances and physical factors
0.722 0.278 0.000
Q38-Q45 Other congenital malformations of the digestive system
0.721 0.279 0.000
I85.9 Oesophageal varices without bleeding
0.721 0.279 0.000
E10.5 With peripheral circulatory complications
0.720 0.280 0.000
E34 Other endocrine disorders
0.719 0.281 0.000
H53.2 Diplopia
0.719 0.281 0.000
S81.0 Open wound of knee
0.718 0.282 0.000
T33-T35 Frostbite
0.717 0.283 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.717 0.283 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.717 0.283 0.000
T00-T07 Injuries involving multiple body regions
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
I00-I02 Acute rheumatic fever
0.717 0.283 0.000
E40-E46 Malnutrition
0.717 0.283 0.000
H44 Disorders of globe
0.716 0.284 0.000
F05 Delirium, not induced by alcohol and other psychoactive substances
0.716 0.284 0.000
H10-H13 Disorders of conjunctiva
0.716 0.284 0.000
F90-F98 Behavioural and emotional disorders with onset usually occurring in childhood and adolescence
0.716 0.284 0.000
F70-F79 Mental retardation
0.716 0.284 0.000
S64 Injury of nerves at wrist and hand level
0.715 0.285 0.000
E12 Malnutrition-related diabetes mellitus
0.715 0.285 0.000
S88 Traumatic amputation of lower leg
0.715 0.285 0.000
S87 Crushing injury of lower leg
0.715 0.285 0.000
S85 Injury of blood vessels at lower leg level
0.715 0.285 0.000
S84 Injury of nerves at lower leg level
0.715 0.285 0.000
D55-D59 Haemolytic anaemias
0.715 0.285 0.000
D51.9 Vitamin B12 deficiency anaemia, unspecified
0.715 0.285 0.000
S08 Traumatic amputation of part of head
0.714 0.285 0.000
S07 Crushing injury of head
0.714 0.285 0.000
S04 Injury of cranial nerves
0.714 0.285 0.000
S03 Dislocation, sprain and strain of joints and ligaments of head
0.714 0.285 0.000
D53 Other nutritional anaemias
0.714 0.286 0.000
H20 Iridocyclitis
0.714 0.286 0.000
H26.4 After-cataract
0.714 0.286 0.000
H16 Keratitis
0.713 0.287 0.000
Y90-Y98 Supplementary factors related to causes of morbidity and mortality classified elsewhere
0.713 0.287 0.000
D50.1 Sideropenic dysphagia
0.711 0.288 0.000
T90.9 Sequelae of unspecified injury of head
0.711 0.289 0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use
0.710 0.290 0.000
Y35-Y36 Legal intervention and operations of war
0.710 0.290 0.000
Y10-Y34 Event of undetermined intent
0.710 0.290 0.000
Y00-Y09 Assault
0.710 0.290 0.000
X85-X99 Assault
0.710 0.290 0.000
X58-X59 Accidental exposure to other and unspecified factors
0.710 0.290 0.000
X50-X57 Overexertion, travel and privation
0.710 0.290 0.000
X30-X39 Exposure to forces of nature
0.710 0.290 0.000
X10-X19 Contact with heat and hot substances
0.710 0.290 0.000
X00-X09 Exposure to smoke, fire and flames
0.710 0.290 0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure
0.710 0.290 0.000
W75-W84 Other accidental threats to breathing
0.710 0.290 0.000
W65-W74 Accidental drowning and submersion
0.710 0.290 0.000
V98-V99 Other and unspecified transport accidents
0.710 0.290 0.000
V95-V97 Air and space transport accidents
0.710 0.290 0.000
V90-V94 Water transport accidents
0.710 0.290 0.000
V80-V89 Other land transport accidents
0.710 0.290 0.000
V70-V79 Bus occupant injured in transport accident
0.710 0.290 0.000
V60-V69 Occupant of heavy transport vehicle injured in transport accident
0.710 0.290 0.000
V50-V59 Occupant of pick-up truck or van injured in transport accident
0.710 0.290 0.000
V40-V49 Car occupant injured in transport accident
0.710 0.290 0.000
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident
0.710 0.290 0.000
V01-V09 Pedestrian injured in transport accident
0.710 0.290 0.000
S86.8 Injury of other muscles and tendons at lower leg level
0.710 0.290 0.000
H35.6 Retinal haemorrhage
0.708 0.292 0.000
S86.9 Injury of unspecified muscle and tendon at lower leg level
0.708 0.292 0.000
I99 Other and unspecified disorders of circulatory system
0.708 0.292 0.000
S82.4 Fracture of fibula alone
0.707 0.293 0.000
E10.8 With unspecified complications
0.706 0.293 0.000
E10.7 With multiple complications
0.706 0.293 0.000
E10.6 With other specified complications
0.706 0.293 0.000
E10.2 With renal complications
0.706 0.293 0.000
E10.0 With coma
0.706 0.293 0.000
H32 Chorioretinal disorders in diseases classified elsewhere
0.706 0.294 0.000
H31 Other disorders of choroid
0.706 0.294 0.000
H30 Chorioretinal inflammation
0.706 0.294 0.000
I27 Other pulmonary heart diseases
0.705 0.295 0.000
S62.3 Fracture of other metacarpal bone
0.705 0.295 0.000
S51.9 Open wound of forearm, part unspecified
0.704 0.296 0.000
I63.5 Cerebral infarction due to unspecified occlusion or stenosis of cerebral arteries
0.703 0.297 0.000
S63 Dislocation, sprain and strain of joints and ligaments at wrist and hand level
0.702 0.298 0.000
D69 Purpura and other haemorrhagic conditions
0.701 0.299 0.000
H35.9 Retinal disorder, unspecified
0.701 0.299 0.000
H35.7 Separation of retinal layers
0.701 0.299 0.000
H35.5 Hereditary retinal dystrophy
0.701 0.299 0.000
H35.2 Other proliferative retinopathy
0.701 0.299 0.000
H35.1 Retinopathy of prematurity
0.701 0.299 0.000
I71.9 Aortic aneurysm of unspecified site, without mention of rupture
0.700 0.300 0.000
I13 Hypertensive heart and renal disease
0.699 0.301 0.000
Chapter XXII Codes for special purposes
0.699 0.301 0.000
D68.2 Hereditary deficiency of other clotting factors
0.698 0.302 0.000
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.698 0.302 0.000
E00 Congenital iodine-deficiency syndrome
0.698 0.302 0.000
E02 Subclinical iodine-deficiency hypothyroidism
0.698 0.302 0.000
Q80-Q89 Other congenital malformations
0.696 0.304 0.000
S51.0 Open wound of elbow
0.696 0.304 0.000
D52 Folate deficiency anaemia
0.696 0.304 0.000
I86 Varicose veins of other sites
0.696 0.304 0.000
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]
0.695 0.305 0.000
E11.6 With other specified complications
0.695 0.305 0.000
E50-E64 Other nutritional deficiencies
0.695 0.305 0.000
Y54 Agents primarily affecting water-balance and mineral and uric acid metabolism
0.694 0.306 0.000
H53.9 Visual disturbance, unspecified
0.694 0.306 0.000
H25 Senile cataract
0.693 0.307 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.693 0.307 0.000
Y42.0 Glucocorticoids and synthetic analogs
0.692 0.308 0.000
E03.8 Other specified hypothyroidism
0.692 0.308 0.000
E03.5 Myxoedema coma
0.692 0.308 0.000
E03.4 Atrophy of thyroid (acquired)
0.692 0.308 0.000
E03.3 Postinfectious hypothyroidism
0.692 0.308 0.000
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.692 0.308 0.000
E03.1 Congenital hypothyroidism without goitre
0.692 0.308 0.000
E03.0 Congenital hypothyroidism with diffuse goitre
0.692 0.308 0.000
F22.0 Delusional disorder
0.691 0.309 0.000
E11.2 With renal complications
0.691 0.309 0.000
W18.5 Trade and service area
0.690 0.310 0.000
E11.7 With multiple complications
0.690 0.310 0.000
E11.1 With ketoacidosis
0.690 0.310 0.000
E24 Cushing's syndrome
0.690 0.310 0.000
T51 Toxic effect of alcohol
0.690 0.310 0.000
H22 Disorders of iris and ciliary body in diseases classified elsewhere
0.690 0.310 0.000
H19 Disorders of sclera and cornea in diseases classified elsewhere
0.690 0.310 0.000
H17 Corneal scars and opacities
0.690 0.310 0.000
H15 Disorders of sclera
0.690 0.310 0.000
I61 Intracerebral haemorrhage
0.688 0.312 0.000
S82.9 Fracture of lower leg, part unspecified
0.688 0.312 0.000
S82.7 Multiple fractures of lower leg
0.688 0.312 0.000
S59 Other and unspecified injuries of forearm
0.688 0.312 0.000
S58 Traumatic amputation of forearm
0.688 0.312 0.000
S57 Crushing injury of forearm
0.688 0.312 0.000
S56 Injury of muscle and tendon at forearm level
0.688 0.312 0.000
S55 Injury of blood vessels at forearm level
0.688 0.312 0.000
S54 Injury of nerves at forearm level
0.688 0.312 0.000
S53 Dislocation, sprain and strain of joints and ligaments of elbow
0.688 0.312 0.000
T66-T78 Other and unspecified effects of external causes
0.687 0.313 0.000
E11.5 With peripheral circulatory complications
0.687 0.313 0.000
I07 Rheumatic tricuspid valve diseases
0.686 0.314 0.000
S09.9 Unspecified injury of head
0.685 0.315 0.000
F38 Other mood [affective] disorders
0.685 0.315 0.000
F30 Manic episode
0.685 0.315 0.000
F39 Unspecified mood [affective] disorder
0.685 0.315 0.000
H21.0 Hyphaema
0.685 0.315 0.000
F19 Mental and behavioural disorders due to multiple drug use and use of other psychoactive substances
0.684 0.315 0.000
F18 Mental and behavioural disorders due to use of volatile solvents
0.684 0.315 0.000
F16 Mental and behavioural disorders due to use of hallucinogens
0.684 0.315 0.000
F15 Mental and behavioural disorders due to use of other stimulants, including caffeine
0.684 0.315 0.000
F14 Mental and behavioural disorders due to use of cocaine
0.684 0.315 0.000
F13 Mental and behavioural disorders due to use of sedatives or hypnotics
0.684 0.315 0.000
F12 Mental and behavioural disorders due to use of cannabinoids
0.684 0.315 0.000
F11 Mental and behavioural disorders due to use of opioids
0.684 0.315 0.000
S00.0 Superficial injury of scalp
0.685 0.315 0.000
F10.4 Withdrawal state with delirium
0.684 0.316 0.000
I64 Stroke, not specified as haemorrhage or infarction
0.684 0.316 0.000
S02.2 Fracture of nasal bones
0.684 0.316 0.000
Y59 Other and unspecified vaccines and biological substances
0.684 0.316 0.000
Y58 Bacterial vaccines
0.684 0.316 0.000
Y56 Topical agents primarily affecting skin and mucous membrane and ophthalmological, otorhinolaryngological and dental drugs
0.684 0.316 0.000
Y55 Agents primarily acting on smooth and skeletal muscles and the respiratory system
0.684 0.316 0.000
Y53 Agents primarily affecting the gastro-intestinal system
0.684 0.316 0.000
Y50 Central nervous system stimulants, not elsewhere classified
0.684 0.316 0.000
Y49 Psychotropic drugs, not elsewhere classified
0.684 0.316 0.000
Y48 Anaesthetics and therapeutic gases
0.684 0.316 0.000
Y47 Sedatives, hypnotics and antianxiety drugs
0.684 0.316 0.000
V20-V29 Motorcycle rider injured in transport accident
0.683 0.317 0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.682 0.317 0.000
S83.2 Tear of meniscus, current
0.682 0.318 0.000
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs
0.682 0.318 0.000
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system
0.682 0.318 0.000
T47 Poisoning by agents primarily affecting gastro-intestinal system
0.682 0.318 0.000
T46 Poisoning by agents primarily affecting the cardiovascular system
0.682 0.318 0.000
T41 Poisoning by anaesthetics and therapeutic gases
0.682 0.318 0.000
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.682 0.318 0.000
T37 Poisoning by other systemic anti-infectives and antiparasitics
0.682 0.318 0.000
T36 Poisoning by systemic antibiotics
0.682 0.318 0.000
H46-H48 Disorders of optic nerve and visual pathways
0.682 0.318 0.000
I70.2 Atherosclerosis of arteries of the extremities
0.681 0.319 0.000
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances
0.680 0.320 0.000
I62.0 Subdural haemorrhage (acute) (nontraumatic)
0.680 0.320 0.000
Y40 Systemic antibiotics
0.679 0.321 0.000
I71.3 Abdominal aortic aneurysm, ruptured
0.678 0.322 0.000
S82.86 Maisonneuve's fracture
0.677 0.322 0.000
S06 Intracranial injury
0.677 0.323 0.000
Y83-Y84 Surgical and other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
0.676 0.324 0.000
H57 Other disorders of eye and adnexa
0.675 0.325 0.000
I63.2 Cerebral infarction due to unspecified occlusion or stenosis of precerebral arteries
0.675 0.325 0.000
Q60-Q64 Congenital malformations of the urinary system
0.674 0.325 0.000
D51.8 Other vitamin B12 deficiency anaemias
0.674 0.326 0.000
D51.3 Other dietary vitamin B12 deficiency anaemia
0.674 0.326 0.000
D51.2 Transcobalamin II deficiency
0.674 0.326 0.000
D51.1 Vitamin B12 deficiency anaemia due to selective vitamin B12 malabsorption with proteinuria
0.674 0.326 0.000
S81.8 Open wound of other parts of lower leg
0.673 0.327 0.000
S65 Injury of blood vessels at wrist and hand level
0.673 0.327 0.000
I68 Cerebrovascular disorders in diseases classified elsewhere
0.673 0.327 0.000
I66 Occlusion and stenosis of cerebral arteries, not resulting in cerebral infarction
0.673 0.327 0.000
T90.4 Sequelae of injury of eye and orbit
0.672 0.328 0.000
I73.8 Other specified peripheral vascular diseases
0.671 0.329 0.000
I73.1 Thromboangiitis obliterans [Buerger]
0.671 0.329 0.000
Chapter II Neoplasms
0.670 0.330 0.000
S01.4 Open wound of cheek and temporomandibular area
0.670 0.330 0.000
S61.9 Open wound of wrist and hand, part unspecified
0.670 0.330 0.000
S69 Other and unspecified injuries of wrist and hand
0.668 0.332 0.000
W10 Fall on and from stairs and steps
0.668 0.332 0.000
I81 Portal vein thrombosis
0.667 0.333 0.000
H53.6 Night blindness
0.666 0.334 0.000
H53.5 Colour vision deficiencies
0.666 0.334 0.000
H53.3 Other disorders of binocular vision
0.666 0.334 0.000
T79.3 Post-traumatic wound infection, not elsewhere classified
0.666 0.334 0.000
S79 Other and unspecified injuries of hip and thigh
0.666 0.334 0.000
S80.0 Contusion of knee
0.665 0.335 0.000
H43 Disorders of vitreous body
0.665 0.335 0.000
S66.1 Injury of flexor muscle and tendon of other finger at wrist and hand level
0.665 0.335 0.000
S70 Superficial injury of hip and thigh
0.665 0.335 0.000
F99 Mental disorder, not otherwise specified
0.663 0.337 0.000
T98 Sequelae of other and unspecified effects of external causes
0.663 0.337 0.000
T95 Sequelae of burns, corrosions and frostbite
0.663 0.337 0.000
T94 Sequelae of injuries involving multiple and unspecified body regions
0.663 0.337 0.000
T97 Sequelae of toxic effects of substances chiefly nonmedicinal as to source
0.663 0.337 0.000
T96 Sequelae of poisoning by drugs, medicaments and biological substances
0.663 0.337 0.000
I63.9 Cerebral infarction, unspecified
0.662 0.338 0.000
Chapter XII Diseases of the skin and subcutaneous tissue
0.661 0.339 0.000
H53.0 Amblyopia ex anopsia
0.661 0.339 0.000
W17 Other fall from one level to another
0.659 0.341 0.000
S52.1 Fracture of upper end of radius
0.659 0.341 0.000
T91 Sequelae of injuries of neck and trunk
0.659 0.341 0.000
F33.8 Other recurrent depressive disorders
0.658 0.342 0.000
F33.4 Recurrent depressive disorder, currently in remission
0.658 0.342 0.000
F33.3 Recurrent depressive disorder, current episode severe with psychotic symptoms
0.658 0.342 0.000
F33.0 Recurrent depressive disorder, current episode mild
0.658 0.342 0.000
Y51.7 Beta-Adrenoreceptor antagonists, not elsewhere classified
0.658 0.342 0.000
Y42.8 Other and unspecified hormones and their synthetic substitutes
0.657 0.343 0.000
E35 Disorders of endocrine glands in diseases classified elsewhere
0.656 0.344 0.000
E32 Diseases of thymus
0.656 0.344 0.000
E31 Polyglandular dysfunction
0.656 0.344 0.000
E30 Disorders of puberty, not elsewhere classified
0.656 0.344 0.000
E26 Hyperaldosteronism
0.656 0.344 0.000
E25 Adrenogenital disorders
0.656 0.344 0.000
E20 Hypoparathyroidism
0.656 0.344 0.000
S90 Superficial injury of ankle and foot
0.656 0.344 0.000
S00.7 Multiple superficial injuries of head
0.656 0.344 0.000
S00.5 Superficial injury of lip and oral cavity
0.656 0.344 0.000
S00.4 Superficial injury of ear
0.656 0.344 0.000
D80-D89 Certain disorders involving the immune mechanism
0.654 0.346 0.000
H54.4 Blindness, one eye
0.653 0.347 0.000
S80.1 Contusion of other and unspecified parts of lower leg
0.653 0.347 0.000
C64-C68 Malignant neoplasms of urinary tract
0.653 0.347 0.000
E28 Ovarian dysfunction
0.652 0.348 0.000
I63.4 Cerebral infarction due to embolism of cerebral arteries
0.652 0.348 0.000
F00 Dementia in Alzheimer's disease
0.651 0.348 0.000
I71.8 Aortic aneurysm of unspecified site, ruptured
0.651 0.349 0.000
I71.6 Thoracoabdominal aortic aneurysm, without mention of rupture
0.651 0.349 0.000
I71.5 Thoracoabdominal aortic aneurysm, ruptured
0.651 0.349 0.000
I71.1 Thoracic aortic aneurysm, ruptured
0.651 0.349 0.000
S66.3 Injury of extensor muscle and tendon of other finger at wrist and hand level
0.651 0.349 0.000
T92 Sequelae of injuries of upper limb
0.650 0.350 0.000
S82.3 Fracture of lower end of tibia
0.650 0.350 0.000
H18.8 Other specified disorders of cornea
0.649 0.350 0.000
I05 Rheumatic mitral valve diseases
0.649 0.351 0.000
E22.1 Hyperprolactinaemia
0.649 0.351 0.000
H54.7 Unspecified visual loss
0.649 0.351 0.000
S52.5 Fracture of lower end of radius
0.649 0.351 0.000
I98.2 Oesophageal varices in diseases classified elsewhere
0.648 0.352 0.000
I71.0 Dissection of aorta [any part]
0.648 0.352 0.000
I74.9 Embolism and thrombosis of unspecified artery
0.647 0.352 0.000
I74.4 Embolism and thrombosis of arteries of extremities, unspecified
0.647 0.352 0.000
I74.1 Embolism and thrombosis of other and unspecified parts of aorta
0.647 0.352 0.000
I74.0 Embolism and thrombosis of abdominal aorta
0.647 0.352 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.647 0.352 0.000
S02.5 Fracture of tooth
0.647 0.353 0.000
S62.30 Fracture of other metacarpal bone (closed)
0.647 0.353 0.000
Y52.1 Calcium-channel blockers
0.645 0.355 0.000
S80.8 Other superficial injuries of lower leg
0.645 0.355 0.000
F31.9 Bipolar affective disorder, unspecified
0.644 0.355 0.000
J40-J47 Chronic lower respiratory diseases
0.644 0.356 0.000
Y44 Agents primarily affecting blood constituents
0.644 0.356 0.000
I28 Other diseases of pulmonary vessels
0.644 0.356 0.000
S52.60 Fracture of lower end of both ulna and radius (closed)
0.644 0.356 0.000
S19.9 Unspecified injury of neck
0.643 0.356 0.000
F60 Specific personality disorders
0.643 0.357 0.000
E15 Nondiabetic hypoglycaemic coma
0.642 0.357 0.000
I08 Multiple valve diseases
0.642 0.358 0.000
I11.9 Hypertensive heart disease without (congestive) heart failure
0.641 0.358 0.000
I60.1 Subarachnoid haemorrhage from middle cerebral artery
0.641 0.359 0.000
I82.2 Embolism and thrombosis of vena cava
0.641 0.359 0.000
D67 Hereditary factor IX deficiency
0.641 0.359 0.000
D66 Hereditary factor VIII deficiency
0.641 0.359 0.000
D65 Disseminated intravascular coagulation [defibrination syndrome]
0.641 0.359 0.000
I74.2 Embolism and thrombosis of arteries of the upper extremities
0.640 0.360 0.000
S60.8 Other superficial injuries of wrist and hand
0.640 0.360 0.000
Q90-Q99 Chromosomal abnormalities, not elsewhere classified
0.640 0.360 0.000
Q35-Q37 Cleft lip and cleft palate
0.640 0.360 0.000
Q30-Q34 Congenital malformations of the respiratory system
0.640 0.360 0.000
Q10-Q18 Congenital malformations of eye, ear, face and neck
0.640 0.360 0.000
H59 Postprocedural disorders of eye and adnexa, not elsewhere classified
0.640 0.360 0.000
V19 Pedal cyclist injured in other and unspecified transport accidents
0.639 0.360 0.000
V17 Pedal cyclist injured in collision with fixed or stationary object
0.639 0.360 0.000
V16 Pedal cyclist injured in collision with other nonmotor vehicle
0.639 0.360 0.000
V15 Pedal cyclist injured in collision with railway train or railway vehicle
0.639 0.360 0.000
V14 Pedal cyclist injured in collision with heavy transport vehicle or bus
0.639 0.360 0.000
V13 Pedal cyclist injured in collision with car, pick-up truck or van
0.639 0.360 0.000
V12 Pedal cyclist injured in collision with two- or three-wheeled motor vehicle
0.639 0.360 0.000
V11 Pedal cyclist injured in collision with other pedal cycle
0.639 0.360 0.000
V10 Pedal cyclist injured in collision with pedestrian or animal
0.639 0.360 0.000
Y52.3 Coronary vasodilators, not elsewhere classified
0.639 0.361 0.000
H26.8 Other specified cataract
0.639 0.361 0.000
S82.1 Fracture of upper end of tibia
0.638 0.362 0.000
C67 Malignant neoplasm of bladder
0.638 0.362 0.000
S66.8 Injury of other muscles and tendons at wrist and hand level
0.636 0.364 0.000
Y42.7 Androgens and anabolic congeners
0.635 0.365 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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