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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs116243243
log Bayes Factor = 8.44204
Chromosome 3   position 153,086,913  (GRCh37) Explore rs116243243 on Ensembl!
Variant rs116243243 is part of Cluster X0169

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
Chapter II Neoplasms
1.000 0.000 0.000
# Top node
1.000 0.000 0.000
D12 Benign neoplasm of colon, rectum, anus and anal canal
1.000 0.000 0.000
D10-D36 Benign neoplasms
0.999 0.001 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
0.998 0.002 0.000
Chapter V Mental and behavioural disorders
0.997 0.003 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.989 0.011 0.000
D32 Benign neoplasm of meninges
0.986 0.014 0.000
Chapter VIII Diseases of the ear and mastoid process
0.985 0.015 0.000
C15-C26 Malignant neoplasms of digestive organs
0.984 0.016 0.000
D12.5 Sigmoid colon
0.978 0.022 0.000
H90-H95 Other disorders of ear
0.977 0.023 0.000
S00-S09 Injuries to the head
0.973 0.027 0.000
D12.6 Colon, unspecified
0.972 0.028 0.000
T36-T50 Poisoning by drugs, medicaments and biological substances
0.970 0.030 0.000
Chapter XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
0.965 0.035 0.000
R90-R94 Abnormal findings on diagnostic imaging and in function studies, without diagnosis
0.964 0.036 0.000
H91 Other hearing loss
0.963 0.037 0.000
D12.7 Rectosigmoid junction
0.963 0.037 0.000
C76-C80 Malignant neoplasms of ill-defined, secondary and unspecified sites
0.962 0.038 0.000
D12.8 Rectum
0.960 0.040 0.000
H91.9 Hearing loss, unspecified
0.954 0.046 0.000
D32.0 Cerebral meninges
0.953 0.047 0.000
C20 Malignant neoplasm of rectum
0.951 0.049 0.000
S01 Open wound of head
0.950 0.050 0.000
D37-D48 Neoplasms of uncertain or unknown behaviour
0.947 0.053 0.000
E50-E64 Other nutritional deficiencies
0.946 0.054 0.000
C73-C75 Malignant neoplasms of thyroid and other endocrine glands
0.937 0.063 0.000
C79 Secondary malignant neoplasm of other sites
0.936 0.064 0.000
C45-C49 Malignant neoplasms of mesothelial and soft tissue
0.935 0.065 0.000
D12.3 Transverse colon
0.931 0.069 0.000
R40-R46 Symptoms and signs involving cognition, perception, emotional state and behaviour
0.928 0.072 0.000
F30-F39 Mood [affective] disorders
0.926 0.074 0.000
C30-C39 Malignant neoplasms of respiratory and intrathoracic organs
0.911 0.089 0.000
R93 Abnormal findings on diagnostic imaging of other body structures
0.909 0.091 0.000
R91 Abnormal findings on diagnostic imaging of lung
0.909 0.091 0.000
F50-F59 Behavioural syndromes associated with physiological disturbances and physical factors
0.907 0.093 0.000
D47 Other neoplasms of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue
0.907 0.093 0.000
Chapter I Certain infectious and parasitic diseases
0.907 0.093 0.000
D13 Benign neoplasm of other and ill-defined parts of digestive system
0.906 0.094 0.000
S01.5 Open wound of lip and oral cavity
0.902 0.098 0.000
F00-F09 Organic, including symptomatic, mental disorders
0.899 0.101 0.000
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]
0.898 0.102 0.000
E55 Vitamin D deficiency
0.897 0.103 0.000
S90-S99 Injuries to the ankle and foot
0.897 0.103 0.000
C73 Malignant neoplasm of thyroid gland
0.892 0.108 0.000
F10-F19 Mental and behavioural disorders due to psychoactive substance use
0.888 0.112 0.000
C79.3 Secondary malignant neoplasm of brain and cerebral meninges
0.887 0.113 0.000
E00-E07 Disorders of thyroid gland
0.883 0.117 0.000
R94 Abnormal results of function studies
0.880 0.120 0.000
D26 Other benign neoplasms of uterus
0.880 0.120 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.880 0.120 0.000
R41 Other symptoms and signs involving cognitive functions and awareness
0.877 0.123 0.000
D32.9 Meninges, unspecified
0.871 0.129 0.000
T43 Poisoning by psychotropic drugs, not elsewhere classified
0.867 0.133 0.000
S10-S19 Injuries to the neck
0.866 0.134 0.000
E55.9 Vitamin D deficiency, unspecified
0.862 0.138 0.000
R93.1 Abnormal findings on diagnostic imaging of heart and coronary circulation
0.861 0.139 0.000
C45 Mesothelioma
0.857 0.142 0.000
S70-S79 Injuries to the hip and thigh
0.857 0.143 0.000
S01.0 Open wound of scalp
0.852 0.148 0.000
T40.2 Other opioids
0.851 0.149 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.850 0.150 0.000
R47-R49 Symptoms and signs involving speech and voice
0.850 0.150 0.000
H90 Conductive and sensorineural hearing loss
0.850 0.150 0.000
R94.5 Abnormal results of liver function studies
0.849 0.151 0.000
D13.1 Stomach
0.845 0.155 0.000
F10 Mental and behavioural disorders due to use of alcohol
0.844 0.156 0.000
D00-D09 In situ neoplasms
0.843 0.157 0.000
R93.5 Abnormal findings on diagnostic imaging of other abdominal regions, including retroperitoneum
0.837 0.163 0.000
F31 Bipolar affective disorder
0.837 0.163 0.000
F00 Dementia in Alzheimer's disease
0.837 0.163 0.000
F52 Sexual dysfunction, not caused by organic disorder or disease
0.834 0.166 0.000
C34 Malignant neoplasm of bronchus and lung
0.833 0.167 0.000
S00 Superficial injury of head
0.832 0.168 0.000
C16 Malignant neoplasm of stomach
0.828 0.172 0.000
S05 Injury of eye and orbit
0.828 0.172 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.823 0.176 0.000
Chapter VI Diseases of the nervous system
0.823 0.177 0.000
C21 Malignant neoplasm of anus and anal canal
0.821 0.179 0.000
C69-C72 Malignant neoplasms of eye, brain and other parts of central nervous system
0.820 0.180 0.000
E10-E14 Diabetes mellitus
0.820 0.180 0.000
C78 Secondary malignant neoplasm of respiratory and digestive organs
0.819 0.181 0.000
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx
0.818 0.182 0.000
T43.0 Tricyclic and tetracyclic antidepressants
0.817 0.183 0.000
R90 Abnormal findings on diagnostic imaging of central nervous system
0.813 0.187 0.000
F10.0 Acute intoxication
0.812 0.188 0.000
C79.9 Secondary malignant neoplasm, unspecified site
0.810 0.190 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.808 0.192 0.000
H65-H75 Diseases of middle ear and mastoid
0.806 0.194 0.000
D47.2 Monoclonal gammopathy
0.806 0.194 0.000
E05 Thyrotoxicosis [hyperthyroidism]
0.803 0.197 0.000
E53 Deficiency of other B group vitamins
0.801 0.199 0.000
D12.2 Ascending colon
0.800 0.200 0.000
C78.0 Secondary malignant neoplasm of lung
0.798 0.202 0.000
D32.1 Spinal meninges
0.795 0.205 0.000
C22 Malignant neoplasm of liver and intrahepatic bile ducts
0.795 0.205 0.000
F80-F89 Disorders of psychological development
0.794 0.206 0.000
R41.3 Other amnesia
0.793 0.207 0.000
D47.1 Chronic myeloproliferative disease
0.790 0.210 0.000
R44 Other symptoms and signs involving general sensations and perceptions
0.787 0.213 0.000
C79.8 Secondary malignant neoplasm of other specified sites
0.785 0.215 0.000
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified
0.783 0.217 0.000
D26.9 Uterus, unspecified
0.783 0.217 0.000
E10 Insulin-dependent diabetes mellitus
0.782 0.218 0.000
B95-B98 Bacterial, viral and other infectious agents
0.781 0.219 0.000
F52.2 Failure of genital response
0.781 0.219 0.000
Chapter XXII Codes for special purposes
0.780 0.220 0.000
S92 Fracture of foot, except ankle
0.777 0.223 0.000
S00.8 Superficial injury of other parts of head
0.776 0.224 0.000
D38 Neoplasm of uncertain or unknown behaviour of middle ear and respiratory and intrathoracic organs
0.773 0.227 0.000
F30 Manic episode
0.770 0.230 0.000
R47 Speech disturbances, not elsewhere classified
0.770 0.230 0.000
F99-F99 Unspecified mental disorder
0.770 0.230 0.000
B35-B49 Mycoses
0.768 0.231 0.000
R45 Symptoms and signs involving emotional state
0.768 0.232 0.000
C43-C44 Melanoma and other malignant neoplasms of skin
0.766 0.234 0.000
S01.8 Open wound of other parts of head
0.763 0.237 0.000
B96 Other bacterial agents as the cause of diseases classified to other chapters
0.761 0.239 0.000
F60-F69 Disorders of adult personality and behaviour
0.760 0.240 0.000
H93 Other disorders of ear, not elsewhere classified
0.760 0.240 0.000
C80 Malignant neoplasm without specification of site
0.760 0.240 0.000
S12 Fracture of neck
0.760 0.240 0.000
D10 Benign neoplasm of mouth and pharynx
0.759 0.241 0.000
F00.9 Dementia in Alzheimer's disease, unspecified
0.758 0.242 0.000
E70-E90 Metabolic disorders
0.758 0.242 0.000
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances
0.757 0.243 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.755 0.245 0.000
C45.0 Mesothelioma of pleura
0.754 0.246 0.000
D39 Neoplasm of uncertain or unknown behaviour of female genital organs
0.753 0.247 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.749 0.251 0.000
B99-B99 Other infectious diseases
0.748 0.252 0.000
S99 Other and unspecified injuries of ankle and foot
0.745 0.255 0.000
R92 Abnormal findings on diagnostic imaging of breast
0.745 0.255 0.000
D47.3 Essential (haemorrhagic) thrombocythaemia
0.744 0.255 0.000
C34.9 Bronchus or lung, unspecified
0.744 0.256 0.000
S30 Superficial injury of abdomen, lower back and pelvis
0.744 0.256 0.000
D29 Benign neoplasm of male genital organs
0.743 0.257 0.000
F10.1 Harmful use
0.743 0.257 0.000
D07 Carcinoma in situ of other and unspecified genital organs
0.743 0.257 0.000
C34.3 Lower lobe, bronchus or lung
0.741 0.259 0.000
B96.8 Other specified bacterial agents as the cause of diseases classified to other chapters
0.740 0.260 0.000
R83-R89 Abnormal findings on examination of other body fluids, substances and tissues, without diagnosis
0.740 0.260 0.000
C23 Malignant neoplasm of gallbladder
0.740 0.260 0.000
R41.8 Other and unspecified symptoms and signs involving cognitive functions and awareness
0.740 0.260 0.000
T90 Sequelae of injuries of head
0.739 0.261 0.000
E20-E35 Disorders of other endocrine glands
0.739 0.261 0.000
R40 Somnolence, stupor and coma
0.739 0.261 0.000
D04 Carcinoma in situ of skin
0.737 0.263 0.000
R47.8 Other and unspecified speech disturbances
0.735 0.265 0.000
A50-A64 Infections with a predominantly sexual mode of transmission
0.735 0.265 0.000
C24 Malignant neoplasm of other and unspecified parts of biliary tract
0.734 0.266 0.000
T00-T07 Injuries involving multiple body regions
0.731 0.269 0.000
C48 Malignant neoplasm of retroperitoneum and peritoneum
0.731 0.269 0.000
C49 Malignant neoplasm of other connective and soft tissue
0.730 0.270 0.000
R70-R79 Abnormal findings on examination of blood, without diagnosis
0.729 0.271 0.000
D12.4 Descending colon
0.728 0.272 0.000
C18 Malignant neoplasm of colon
0.728 0.272 0.000
D43 Neoplasm of uncertain or unknown behaviour of brain and central nervous system
0.728 0.272 0.000
G80-G83 Cerebral palsy and other paralytic syndromes
0.726 0.274 0.000
A00-A09 Intestinal infectious diseases
0.725 0.275 0.000
S01.1 Open wound of eyelid and periocular area
0.722 0.278 0.000
S05.8 Other injuries of eye and orbit
0.722 0.278 0.000
C25 Malignant neoplasm of pancreas
0.721 0.279 0.000
C71 Malignant neoplasm of brain
0.720 0.280 0.000
C40-C41 Malignant neoplasms of bone and articular cartilage
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
D12.1 Appendix
0.717 0.283 0.000
D31 Benign neoplasm of eye and adnexa
0.717 0.283 0.000
D20 Benign neoplasm of soft tissue of retroperitoneum and peritoneum
0.717 0.283 0.000
D19 Benign neoplasm of mesothelial tissue
0.717 0.283 0.000
D15 Benign neoplasm of other and unspecified intrathoracic organs
0.717 0.283 0.000
T33-T35 Frostbite
0.716 0.284 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.716 0.284 0.000
C17 Malignant neoplasm of small intestine
0.716 0.284 0.000
D37 Neoplasm of uncertain or unknown behaviour of oral cavity and digestive organs
0.715 0.285 0.000
F34 Persistent mood [affective] disorders
0.715 0.285 0.000
F90-F98 Behavioural and emotional disorders with onset usually occurring in childhood and adolescence
0.715 0.285 0.000
F70-F79 Mental retardation
0.715 0.285 0.000
C26 Malignant neoplasm of other and ill-defined digestive organs
0.712 0.287 0.000
T91 Sequelae of injuries of neck and trunk
0.712 0.288 0.000
D48 Neoplasm of uncertain or unknown behaviour of other and unspecified sites
0.712 0.288 0.000
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.709 0.291 0.000
H72 Perforation of tympanic membrane
0.708 0.292 0.000
C79.4 Secondary malignant neoplasm of other and unspecified parts of nervous system
0.706 0.294 0.000
T44 Poisoning by drugs primarily affecting the autonomic nervous system
0.705 0.295 0.000
C97-C97 Malignant neoplasms of independent (primary) multiple sites
0.704 0.295 0.000
E06 Thyroiditis
0.704 0.296 0.000
F00.2 Dementia in Alzheimer's disease, atypical or mixed type
0.703 0.297 0.000
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.703 0.297 0.000
R93.2 Abnormal findings on diagnostic imaging of liver and biliary tract
0.703 0.297 0.000
E40-E46 Malnutrition
0.702 0.298 0.000
C45.9 Mesothelioma, unspecified
0.702 0.298 0.000
H90.2 Conductive hearing loss, unspecified
0.701 0.299 0.000
H95 Postprocedural disorders of ear and mastoid process, not elsewhere classified
0.701 0.299 0.000
H94 Other disorders of ear in diseases classified elsewhere
0.701 0.299 0.000
D11 Benign neoplasm of major salivary glands
0.700 0.300 0.000
H90.5 Sensorineural hearing loss, unspecified
0.700 0.300 0.000
S01.2 Open wound of nose
0.699 0.300 0.000
C32 Malignant neoplasm of larynx
0.699 0.300 0.000
Chapter XX External causes of morbidity and mortality
0.699 0.301 0.000
S01.4 Open wound of cheek and temporomandibular area
0.699 0.301 0.000
F33 Recurrent depressive disorder
0.698 0.302 0.000
S08 Traumatic amputation of part of head
0.697 0.302 0.000
S07 Crushing injury of head
0.697 0.302 0.000
S04 Injury of cranial nerves
0.697 0.302 0.000
S03 Dislocation, sprain and strain of joints and ligaments of head
0.697 0.302 0.000
E53.8 Deficiency of other specified B group vitamins
0.697 0.303 0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.696 0.304 0.000
D16 Benign neoplasm of bone and articular cartilage
0.696 0.304 0.000
E05.9 Thyrotoxicosis, unspecified
0.696 0.304 0.000
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs
0.695 0.305 0.000
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system
0.695 0.305 0.000
T47 Poisoning by agents primarily affecting gastro-intestinal system
0.695 0.305 0.000
T46 Poisoning by agents primarily affecting the cardiovascular system
0.695 0.305 0.000
T41 Poisoning by anaesthetics and therapeutic gases
0.695 0.305 0.000
T37 Poisoning by other systemic anti-infectives and antiparasitics
0.695 0.305 0.000
T36 Poisoning by systemic antibiotics
0.695 0.305 0.000
T79-T79 Certain early complications of trauma
0.695 0.305 0.000
H91.8 Other specified hearing loss
0.693 0.307 0.000
C02 Malignant neoplasm of other and unspecified parts of tongue
0.693 0.307 0.000
C22.1 Intrahepatic bile duct carcinoma
0.693 0.307 0.000
F31.3 Bipolar affective disorder, current episode mild or moderate depression
0.693 0.307 0.000
R41.1 Anterograde amnesia
0.693 0.307 0.000
R95-R99 Ill-defined and unknown causes of mortality
0.692 0.308 0.000
R93.0 Abnormal findings on diagnostic imaging of skull and head, not elsewhere classified
0.692 0.308 0.000
C79.5 Secondary malignant neoplasm of bone and bone marrow
0.691 0.309 0.000
H91.3 Deaf mutism, not elsewhere classified
0.691 0.309 0.000
H91.2 Sudden idiopathic hearing loss
0.691 0.309 0.000
H91.1 Presbycusis
0.691 0.309 0.000
H91.0 Ototoxic hearing loss
0.691 0.309 0.000
S40-S49 Injuries to the shoulder and upper arm
0.691 0.309 0.000
C76 Malignant neoplasm of other and ill-defined sites
0.690 0.310 0.000
B90-B94 Sequelae of infectious and parasitic diseases
0.688 0.312 0.000
R93.8 Abnormal findings on diagnostic imaging of other specified body structures
0.688 0.312 0.000
D28 Benign neoplasm of other and unspecified female genital organs
0.687 0.312 0.000
D33 Benign neoplasm of brain and other parts of central nervous system
0.687 0.313 0.000
C79.0 Secondary malignant neoplasm of kidney and renal pelvis
0.686 0.314 0.000
S39 Other and unspecified injuries of abdomen, lower back and pelvis
0.686 0.314 0.000
E05.0 Thyrotoxicosis with diffuse goitre
0.683 0.317 0.000
F50 Eating disorders
0.683 0.317 0.000
E07 Other disorders of thyroid
0.682 0.318 0.000
F20-F29 Schizophrenia, schizotypal and delusional disorders
0.682 0.318 0.000
D34 Benign neoplasm of thyroid gland
0.681 0.319 0.000
S32 Fracture of lumbar spine and pelvis
0.680 0.320 0.000
R90.8 Other abnormal findings on diagnostic imaging of central nervous system
0.680 0.320 0.000
C79.2 Secondary malignant neoplasm of skin
0.679 0.320 0.000
D44 Neoplasm of uncertain or unknown behaviour of endocrine glands
0.679 0.321 0.000
D42 Neoplasm of uncertain or unknown behaviour of meninges
0.679 0.321 0.000
D40 Neoplasm of uncertain or unknown behaviour of male genital organs
0.679 0.321 0.000
D21 Other benign neoplasms of connective and other soft tissue
0.679 0.321 0.000
B00-B09 Viral infections characterized by skin and mucous membrane lesions
0.679 0.321 0.000
E64 Sequelae of malnutrition and other nutritional deficiencies
0.678 0.321 0.000
E63 Other nutritional deficiencies
0.678 0.321 0.000
E56 Other vitamin deficiencies
0.678 0.321 0.000
E51 Thiamine deficiency
0.678 0.321 0.000
E50 Vitamin A deficiency
0.678 0.321 0.000
E60 Dietary zinc deficiency
0.678 0.321 0.000
E59 Dietary selenium deficiency
0.678 0.321 0.000
E58 Dietary calcium deficiency
0.678 0.321 0.000
E54 Ascorbic acid deficiency
0.678 0.321 0.000
E52 Niacin deficiency [pellagra]
0.678 0.321 0.000
E10.8 With unspecified complications
0.678 0.322 0.000
S06 Intracranial injury
0.678 0.322 0.000
E83 Disorders of mineral metabolism
0.678 0.322 0.000
S70 Superficial injury of hip and thigh
0.677 0.323 0.000
S71 Open wound of hip and thigh
0.676 0.324 0.000
S76 Injury of muscle and tendon at hip and thigh level
0.676 0.324 0.000
T90.9 Sequelae of unspecified injury of head
0.676 0.324 0.000
H80-H83 Diseases of inner ear
0.676 0.324 0.000
T98 Sequelae of other and unspecified effects of external causes
0.675 0.325 0.000
C19 Malignant neoplasm of rectosigmoid junction
0.675 0.325 0.000
C75 Malignant neoplasm of other endocrine glands and related structures
0.672 0.328 0.000
C74 Malignant neoplasm of adrenal gland
0.672 0.328 0.000
H92 Otalgia and effusion of ear
0.672 0.328 0.000
C79.1 Secondary malignant neoplasm of bladder and other and unspecified urinary organs
0.671 0.329 0.000
C47 Malignant neoplasm of peripheral nerves and autonomic nervous system
0.670 0.329 0.000
C46 Kaposi's sarcoma
0.670 0.329 0.000
H71 Cholesteatoma of middle ear
0.670 0.330 0.000
S79 Other and unspecified injuries of hip and thigh
0.670 0.330 0.000
S20-S29 Injuries to the thorax
0.669 0.331 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.669 0.331 0.000
F03 Unspecified dementia
0.667 0.333 0.000
D18 Haemangioma and lymphangioma, any site
0.667 0.333 0.000
T66-T78 Other and unspecified effects of external causes
0.667 0.333 0.000
R46 Symptoms and signs involving appearance and behaviour
0.665 0.335 0.000
R43 Disturbances of smell and taste
0.665 0.335 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.665 0.335 0.000
F81 Specific developmental disorders of scholastic skills
0.665 0.335 0.000
F38 Other mood [affective] disorders
0.664 0.336 0.000
F39 Unspecified mood [affective] disorder
0.664 0.336 0.000
C21.1 Anal canal
0.663 0.337 0.000
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs
0.663 0.337 0.000
D46 Myelodysplastic syndromes
0.663 0.337 0.000
R72 Abnormality of white blood cells, not elsewhere classified
0.663 0.337 0.000
E89.0 Postprocedural hypothyroidism
0.662 0.338 0.000
D12.9 Anus and anal canal
0.661 0.338 0.000
F30.9 Manic episode, unspecified
0.660 0.340 0.000
D26.1 Corpus uteri
0.660 0.340 0.000
B37 Candidiasis
0.658 0.342 0.000
R20-R23 Symptoms and signs involving the skin and subcutaneous tissue
0.657 0.343 0.000
S01.3 Open wound of ear
0.657 0.343 0.000
D30 Benign neoplasm of urinary organs
0.656 0.344 0.000
F05 Delirium, not induced by alcohol and other psychoactive substances
0.656 0.344 0.000
R44.3 Hallucinations, unspecified
0.656 0.344 0.000
G30-G32 Other degenerative diseases of the nervous system
0.655 0.345 0.000
S00.5 Superficial injury of lip and oral cavity
0.655 0.345 0.000
C16.3 Pyloric antrum
0.655 0.345 0.000
C45.7 Mesothelioma of other sites
0.654 0.346 0.000
C39 Malignant neoplasm of other and ill-defined sites in the respiratory system and intrathoracic organs
0.653 0.347 0.000
C38 Malignant neoplasm of heart, mediastinum and pleura
0.653 0.347 0.000
C31 Malignant neoplasm of accessory sinuses
0.653 0.347 0.000
C30 Malignant neoplasm of nasal cavity and middle ear
0.653 0.347 0.000
C37 Malignant neoplasm of thymus
0.653 0.347 0.000
C33 Malignant neoplasm of trachea
0.653 0.347 0.000
C05 Malignant neoplasm of palate
0.652 0.348 0.000
R93.6 Abnormal findings on diagnostic imaging of limbs
0.652 0.348 0.000
F31.1 Bipolar affective disorder, current episode manic without psychotic symptoms
0.652 0.348 0.000
G82 Paraplegia and tetraplegia
0.651 0.349 0.000
F31.2 Bipolar affective disorder, current episode manic with psychotic symptoms
0.651 0.349 0.000
B65-B83 Helminthiases
0.651 0.349 0.000
S91 Open wound of ankle and foot
0.650 0.349 0.000
F53 Mental and behavioural disorders associated with the puerperium, not elsewhere classified
0.650 0.349 0.000
F51 Nonorganic sleep disorders
0.650 0.349 0.000
F59 Unspecified behavioural syndromes associated with physiological disturbances and physical factors
0.650 0.349 0.000
F55 Abuse of non-dependence-producing substances
0.650 0.349 0.000
F54 Psychological and behavioural factors associated with disorders or diseases classified elsewhere
0.650 0.349 0.000
D47.9 Neoplasm of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue, unspecified
0.650 0.350 0.000
D47.7 Other specified neoplasms of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue
0.650 0.350 0.000
D47.5 Chronic eosinophilic leukaemia [hypereosinophilic syndrome]
0.650 0.350 0.000
D47.4 Osteomyelofibrosis
0.650 0.350 0.000
D47.0 Histiocytic and mast cell tumours of uncertain and unknown behaviour
0.650 0.350 0.000
B85-B89 Pediculosis, acariasis and other infestations
0.650 0.350 0.000
B50-B64 Protozoal diseases
0.650 0.350 0.000
A92-A99 Arthropod-borne viral fevers and viral haemorrhagic fevers
0.650 0.350 0.000
A75-A79 Rickettsioses
0.650 0.350 0.000
A70-A74 Other diseases caused by chlamydiae
0.650 0.350 0.000
A65-A69 Other spirochaetal diseases
0.650 0.350 0.000
A20-A28 Certain zoonotic bacterial diseases
0.650 0.350 0.000
A15-A19 Tuberculosis
0.650 0.350 0.000
C21.0 Anus, unspecified
0.650 0.350 0.000
D13.9 Ill-defined sites within the digestive system
0.650 0.350 0.000
D13.7 Endocrine pancreas
0.650 0.350 0.000
D13.6 Pancreas
0.650 0.350 0.000
D13.5 Extrahepatic bile ducts
0.650 0.350 0.000
D13.4 Liver
0.650 0.350 0.000
D13.3 Other and unspecified parts of small intestine
0.650 0.350 0.000
D13.0 Oesophagus
0.650 0.350 0.000
T45.0 Antiallergic and antiemetic drugs
0.650 0.350 0.000
E10.1 With ketoacidosis
0.650 0.350 0.000
S13 Dislocation, sprain and strain of joints and ligaments at neck level
0.649 0.351 0.000
D38.1 Trachea, bronchus and lung
0.648 0.352 0.000
S73 Dislocation, sprain and strain of joint and ligaments of hip
0.647 0.352 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.647 0.353 0.000
C78.2 Secondary malignant neoplasm of pleura
0.647 0.353 0.000
H90.0 Conductive hearing loss, bilateral
0.646 0.354 0.000
R45.1 Restlessness and agitation
0.645 0.355 0.000
F07 Personality and behavioural disorders due to brain disease, damage and dysfunction
0.644 0.355 0.000
F02 Dementia in other diseases classified elsewhere
0.644 0.355 0.000
F09 Unspecified organic or symptomatic mental disorder
0.644 0.355 0.000
F04 Organic amnesic syndrome, not induced by alcohol and other psychoactive substances
0.644 0.355 0.000
T40.9 Other and unspecified psychodysleptics [hallucinogens]
0.644 0.356 0.000
T40.8 Lysergide [LSD]
0.644 0.356 0.000
T40.7 Cannabis (derivatives)
0.644 0.356 0.000
T40.6 Other and unspecified narcotics
0.644 0.356 0.000
T40.5 Cocaine
0.644 0.356 0.000
T40.3 Methadone
0.644 0.356 0.000
T40.1 Heroin
0.644 0.356 0.000
T40.0 Opium
0.644 0.356 0.000
S92.3 Fracture of metatarsal bone
0.644 0.356 0.000
E55.0 Rickets, active
0.643 0.357 0.000
S98 Traumatic amputation of ankle and foot
0.643 0.357 0.000
S97 Crushing injury of ankle and foot
0.643 0.357 0.000
S96 Injury of muscle and tendon at ankle and foot level
0.643 0.357 0.000
S95 Injury of blood vessels at ankle and foot level
0.643 0.357 0.000
S94 Injury of nerves at ankle and foot level
0.643 0.357 0.000
S93 Dislocation, sprain and strain of joints and ligaments at ankle and foot level
0.643 0.357 0.000
B96.2 Escherichia coli [E. coli] as the cause of diseases classified to other chapters
0.642 0.358 0.000
T20 Burn and corrosion of head and neck
0.641 0.359 0.000
R41.0 Disorientation, unspecified
0.641 0.359 0.000
E65-E68 Obesity and other hyperalimentation
0.641 0.359 0.000
C51-C58 Malignant neoplasms of female genital organs
0.641 0.359 0.000
R44.1 Visual hallucinations
0.640 0.360 0.000
F31.6 Bipolar affective disorder, current episode mixed
0.640 0.360 0.000
D36 Benign neoplasm of other and unspecified sites
0.639 0.361 0.000
D07.5 Prostate
0.639 0.361 0.000
E61 Deficiency of other nutrient elements
0.638 0.361 0.000
C16.9 Stomach, unspecified
0.638 0.362 0.000
D14 Benign neoplasm of middle ear and respiratory system
0.637 0.363 0.000
F19 Mental and behavioural disorders due to multiple drug use and use of other psychoactive substances
0.637 0.363 0.000
F18 Mental and behavioural disorders due to use of volatile solvents
0.637 0.363 0.000
F16 Mental and behavioural disorders due to use of hallucinogens
0.637 0.363 0.000
F15 Mental and behavioural disorders due to use of other stimulants, including caffeine
0.637 0.363 0.000
F14 Mental and behavioural disorders due to use of cocaine
0.637 0.363 0.000
F13 Mental and behavioural disorders due to use of sedatives or hypnotics
0.637 0.363 0.000
F11 Mental and behavioural disorders due to use of opioids
0.637 0.363 0.000
S99.9 Unspecified injury of ankle and foot
0.636 0.364 0.000
B20-B24 Human immunodeficiency virus [HIV] disease
0.635 0.364 0.000
F31.0 Bipolar affective disorder, current episode hypomanic
0.635 0.365 0.000
E10.4 With neurological complications
0.635 0.365 0.000
B99 Other and unspecified infectious diseases
0.635 0.365 0.000
G50-G59 Nerve, nerve root and plexus disorders
0.633 0.367 0.000
S12.7 Multiple fractures of cervical spine
0.633 0.367 0.000
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.633 0.367 0.000
E00 Congenital iodine-deficiency syndrome
0.633 0.367 0.000
E02 Subclinical iodine-deficiency hypothyroidism
0.633 0.367 0.000
S90 Superficial injury of ankle and foot
0.632 0.367 0.000
E10.0 With coma
0.632 0.368 0.000
R94.8 Abnormal results of function studies of other organs and systems
0.631 0.369 0.000
R94.7 Abnormal results of other endocrine function studies
0.631 0.369 0.000
R94.6 Abnormal results of thyroid function studies
0.631 0.369 0.000
R94.2 Abnormal results of pulmonary function studies
0.631 0.369 0.000
R94.1 Abnormal results of function studies of peripheral nervous system and special senses
0.631 0.369 0.000
R94.0 Abnormal results of function studies of central nervous system
0.631 0.369 0.000
R93.7 Abnormal findings on diagnostic imaging of other parts of musculoskeletal system
0.631 0.369 0.000
D26.7 Other parts of uterus
0.631 0.369 0.000
D26.0 Cervix uteri
0.631 0.369 0.000
S38 Crushing injury and traumatic amputation of part of abdomen, lower back and pelvis
0.631 0.369 0.000
S37 Injury of urinary and pelvic organs
0.631 0.369 0.000
S36 Injury of intra-abdominal organs
0.631 0.369 0.000
S35 Injury of blood vessels at abdomen, lower back and pelvis level
0.631 0.369 0.000
S34 Injury of nerves and lumbar spinal cord at abdomen, lower back and pelvis level
0.631 0.369 0.000
S33 Dislocation, sprain and strain of joints and ligaments of lumbar spine and pelvis
0.631 0.369 0.000
S31 Open wound of abdomen, lower back and pelvis
0.631 0.369 0.000
Q20-Q28 Congenital malformations of the circulatory system
0.631 0.369 0.000
E88 Other metabolic disorders
0.630 0.370 0.000
D10.3 Other and unspecified parts of mouth
0.629 0.371 0.000
R90.0 Intracranial space-occupying lesion
0.628 0.372 0.000
G20-G26 Extrapyramidal and movement disorders
0.627 0.373 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.627 0.373 0.000
D06 Carcinoma in situ of cervix uteri
0.626 0.374 0.000
D13.2 Duodenum
0.626 0.374 0.000
Q10-Q18 Congenital malformations of eye, ear, face and neck
0.626 0.374 0.000
C16.5 Lesser curvature of stomach, unspecified
0.626 0.374 0.000
H72.9 Perforation of tympanic membrane, unspecified
0.625 0.375 0.000
C80.0 Malignant neoplasm, primary site unknown, so stated
0.625 0.375 0.000
S50-S59 Injuries to the elbow and forearm
0.624 0.376 0.000
S60-S69 Injuries to the wrist and hand
0.624 0.376 0.000
D04.3 Skin of other and unspecified parts of face
0.623 0.377 0.000
H90.1 Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side
0.623 0.377 0.000
U82-U85 Resistance to antimicrobial and antineoplastic drugs
0.622 0.377 0.000
S19 Other and unspecified injuries of neck
0.622 0.378 0.000
T40.4 Other synthetic narcotics
0.622 0.378 0.000
G90-G99 Other disorders of the nervous system
0.622 0.378 0.000
T43.9 Psychotropic drug, unspecified
0.622 0.378 0.000
T43.8 Other psychotropic drugs, not elsewhere classified
0.622 0.378 0.000
T43.6 Psychostimulants with abuse potential
0.622 0.378 0.000
T43.4 Butyrophenone and thioxanthene neuroleptics
0.622 0.378 0.000
T43.1 Monoamine-oxidase-inhibitor antidepressants
0.622 0.378 0.000
T22 Burn and corrosion of shoulder and upper limb, except wrist and hand
0.621 0.379 0.000
S17 Crushing injury of neck
0.621 0.379 0.000
S15 Injury of blood vessels at neck level
0.621 0.379 0.000
S14 Injury of nerves and spinal cord at neck level
0.621 0.379 0.000
S11 Open wound of neck
0.621 0.379 0.000
S18 Traumatic amputation at neck level
0.621 0.379 0.000
S16 Injury of muscle and tendon at neck level
0.621 0.379 0.000
F06 Other mental disorders due to brain damage and dysfunction and to physical disease
0.620 0.380 0.000
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue
0.618 0.381 0.000
R86 Abnormal findings in specimens from male genital organs
0.618 0.382 0.000
C18.4 Transverse colon
0.617 0.383 0.000
T94 Sequelae of injuries involving multiple and unspecified body regions
0.617 0.383 0.000
F12 Mental and behavioural disorders due to use of cannabinoids
0.617 0.383 0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.616 0.384 0.000
S10 Superficial injury of neck
0.615 0.385 0.000
C45.2 Mesothelioma of pericardium
0.615 0.385 0.000
C45.1 Mesothelioma of peritoneum
0.615 0.385 0.000
S78 Traumatic amputation of hip and thigh
0.615 0.385 0.000
S77 Crushing injury of hip and thigh
0.615 0.385 0.000
S75 Injury of blood vessels at hip and thigh level
0.615 0.385 0.000
S74 Injury of nerves at hip and thigh level
0.615 0.385 0.000
R22 Localised swelling, mass and lump of skin and subcutaneous tissue
0.614 0.386 0.000
D39.1 Ovary
0.614 0.386 0.000
D48.5 Skin
0.614 0.386 0.000
B36 Other superficial mycoses
0.613 0.387 0.000
S92.0 Fracture of calcaneus
0.612 0.388 0.000
A02 Other Salmonella infections
0.611 0.389 0.000
C16.0 Cardia
0.611 0.389 0.000
D04.6 Skin of upper limb, including shoulder
0.611 0.389 0.000
T90.8 Sequelae of other specified injuries of head
0.610 0.390 0.000
T95 Sequelae of burns, corrosions and frostbite
0.610 0.390 0.000
T97 Sequelae of toxic effects of substances chiefly nonmedicinal as to source
0.610 0.390 0.000
T96 Sequelae of poisoning by drugs, medicaments and biological substances
0.610 0.390 0.000
C78.4 Secondary malignant neoplasm of small intestine
0.610 0.390 0.000
R48 Dyslexia and other symbolic dysfunctions, not elsewhere classified
0.609 0.390 0.000
H90.8 Mixed conductive and sensorineural hearing loss, unspecified
0.609 0.391 0.000
H90.7 Mixed conductive and sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
0.609 0.391 0.000
H90.6 Mixed conductive and sensorineural hearing loss, bilateral
0.609 0.391 0.000
H90.4 Sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
0.609 0.391 0.000
W00-W19 Falls
0.609 0.391 0.000
S01.7 Multiple open wounds of head
0.608 0.392 0.000
S12.2 Fracture of other specified cervical vertebra
0.608 0.392 0.000
S30.8 Other superficial injuries of abdomen, lower back and pelvis
0.608 0.392 0.000
F99 Mental disorder, not otherwise specified
0.607 0.393 0.000
C71.1 Frontal lobe
0.607 0.393 0.000
E83.1 Disorders of iron metabolism
0.605 0.394 0.000
F10.9 Unspecified mental and behavioural disorder
0.605 0.395 0.000
F10.8 Other mental and behavioural disorders
0.605 0.395 0.000
F10.7 Residual and late-onset psychotic disorder
0.605 0.395 0.000
F10.6 Amnesic syndrome
0.605 0.395 0.000
F10.5 Psychotic disorder
0.605 0.395 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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