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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs116249078
log Bayes Factor = 11.4951
Chromosome 4   position 69,792,030  (GRCh37) Explore rs116249078 on Ensembl!
Variant rs116249078 is part of Cluster X0052

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
Chapter XIX Injury, poisoning and certain other consequences of external causes
1.000 0.000 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
1.000 0.000 0.000
# Top node
1.000 0.000 0.000
M50-M54 Other dorsopathies
1.000 0.000 0.000
M54 Dorsalgia
0.999 0.001 0.000
M45-M49 Spondylopathies
0.998 0.002 0.000
S00-S09 Injuries to the head
0.997 0.003 0.000
Chapter XV Pregnancy, childbirth and the puerperium
0.995 0.005 0.000
Chapter VI Diseases of the nervous system
0.992 0.008 0.000
S06 Intracranial injury
0.975 0.025 0.000
M54.5 Low back pain
0.974 0.026 0.000
M47 Spondylosis
0.969 0.031 0.000
M54.2 Cervicalgia
0.963 0.037 0.000
G80-G83 Cerebral palsy and other paralytic syndromes
0.958 0.042 0.000
Chapter XX External causes of morbidity and mortality
0.956 0.044 0.000
Chapter X Diseases of the respiratory system
0.956 0.044 0.000
O60-O75 Complications of labour and delivery
0.952 0.048 0.000
T36-T50 Poisoning by drugs, medicaments and biological substances
0.952 0.048 0.000
M51 Other intervertebral disk disorders
0.951 0.049 0.000
Chapter II Neoplasms
0.949 0.051 0.000
T80-T88 Complications of surgical and medical care, not elsewhere classified
0.948 0.052 0.000
Chapter I Certain infectious and parasitic diseases
0.945 0.055 0.000
M48 Other spondylopathies
0.945 0.055 0.000
S01 Open wound of head
0.944 0.056 0.000
J30-J39 Other diseases of upper respiratory tract
0.942 0.058 0.000
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue
0.942 0.058 0.000
M54.22 Cervicalgia (Cervical region)
0.937 0.063 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.926 0.074 0.000
O10-O16 Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium
0.925 0.075 0.000
M54.56 Low back pain (Lumbar region)
0.924 0.076 0.000
Y85-Y89 Sequelae of external causes of morbidity and mortality
0.924 0.076 0.000
G82 Paraplegia and tetraplegia
0.921 0.079 0.000
M45 Ankylosing spondylitis
0.916 0.084 0.000
S80-S89 Injuries to the knee and lower leg
0.916 0.084 0.000
J33 Nasal polyp
0.915 0.085 0.000
J32 Chronic sinusitis
0.911 0.089 0.000
C85 Other and unspecified types of non-Hodgkin's lymphoma
0.905 0.095 0.000
O30-O48 Maternal care related to the fetus and amniotic cavity and possible delivery problems
0.903 0.097 0.000
S70-S79 Injuries to the hip and thigh
0.902 0.098 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.897 0.103 0.000
T85 Complications of other internal prosthetic devices, implants and grafts
0.897 0.103 0.000
M47.8 Other spondylosis
0.894 0.106 0.000
M51.2 Other specified intervertebral disk displacement
0.894 0.106 0.000
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics
0.893 0.107 0.000
M80-M85 Disorders of bone density and structure
0.891 0.109 0.000
O00-O08 Pregnancy with abortive outcome
0.891 0.109 0.000
J33.9 Nasal polyp, unspecified
0.888 0.112 0.000
O68 Labour and delivery complicated by foetal stress [distress]
0.887 0.113 0.000
M54.3 Sciatica
0.886 0.114 0.000
B35-B49 Mycoses
0.886 0.114 0.000
Chapter VIII Diseases of the ear and mastoid process
0.882 0.118 0.000
Y85 Sequelae of transport accidents
0.879 0.121 0.000
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx
0.878 0.121 0.000
S01.5 Open wound of lip and oral cavity
0.872 0.128 0.000
G20-G26 Extrapyramidal and movement disorders
0.870 0.130 0.000
M47.9 Spondylosis, unspecified
0.870 0.130 0.000
M48.0 Spinal stenosis
0.868 0.132 0.000
M50 Cervical disk disorders
0.868 0.132 0.000
G82.2 Paraplegia, unspecified
0.867 0.133 0.000
M54.6 Pain in thoracic spine
0.863 0.137 0.000
O13 Gestational [pregnancy-induced] hypertension without significant proteinuria
0.862 0.138 0.000
C81 Hodgkin's disease
0.860 0.140 0.000
G50-G59 Nerve, nerve root and plexus disorders
0.860 0.140 0.000
M45.X9 Ankylosing spondylitis (Site unspecified)
0.858 0.142 0.000
M40-M43 Deforming dorsopathies
0.856 0.144 0.000
M54.58 Low back pain (Sacral and sacrococcygeal region)
0.855 0.145 0.000
O32 Maternal care for known or suspected malpresentation of foetus
0.854 0.146 0.000
M54.57 Low back pain (Lumbosacral region)
0.854 0.146 0.000
S80 Superficial injury of lower leg
0.854 0.146 0.000
S20-S29 Injuries to the thorax
0.852 0.148 0.000
Chapter XXII Codes for special purposes
0.850 0.150 0.000
C82 Follicular [nodular] non-Hodgkin's lymphoma
0.848 0.152 0.000
Chapter VII Diseases of the eye and adnexa
0.845 0.155 0.000
T39.0 Salicylates
0.845 0.155 0.000
S06.5 Traumatic subdural haemorrhage
0.844 0.156 0.000
J32.9 Chronic sinusitis, unspecified
0.842 0.158 0.000
S00 Superficial injury of head
0.840 0.160 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.840 0.160 0.000
M51.8 Other specified intervertebral disk disorders
0.835 0.165 0.000
O64 Obstructed labour due to malposition and malpresentation of foetus
0.833 0.167 0.000
T90 Sequelae of injuries of head
0.832 0.168 0.000
S06.3 Focal brain injury
0.831 0.169 0.000
S50-S59 Injuries to the elbow and forearm
0.829 0.171 0.000
C85.1 B-cell lymphoma, unspecified
0.827 0.173 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.824 0.176 0.000
S06.2 Diffuse brain injury
0.824 0.176 0.000
B25-B34 Other viral diseases
0.823 0.177 0.000
G90-G99 Other disorders of the nervous system
0.823 0.177 0.000
C76-C80 Malignant neoplasms of ill-defined, secondary and unspecified sites
0.822 0.178 0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.820 0.180 0.000
O32.1 Maternal care for breech presentation
0.820 0.180 0.000
H30-H36 Disorders of choroid and retina
0.819 0.181 0.000
C85.9 Non-Hodgkin's lymphoma, unspecified type
0.819 0.181 0.000
O68.1 Labour and delivery complicated by meconium in amniotic fluid
0.817 0.183 0.000
J09-J18 Influenza and pneumonia
0.817 0.183 0.000
J60-J70 Lung diseases due to external agents
0.816 0.184 0.000
Y85.0 Sequelae of motor-vehicle accident
0.815 0.185 0.000
T46 Poisoning by agents primarily affecting the cardiovascular system
0.815 0.185 0.000
M48.5 Collapsed vertebra, not elsewhere classified
0.811 0.189 0.000
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system
0.809 0.191 0.000
T82 Complications of cardiac and vascular prosthetic devices, implants and grafts
0.809 0.191 0.000
B37 Candidiasis
0.808 0.192 0.000
Y88 Sequelae of surgical and medical care as external cause
0.807 0.193 0.000
S80.9 Superficial injury of lower leg, unspecified
0.806 0.194 0.000
S06.4 Epidural haemorrhage
0.804 0.195 0.000
S01.2 Open wound of nose
0.804 0.196 0.000
C73-C75 Malignant neoplasms of thyroid and other endocrine glands
0.803 0.197 0.000
V40-V49 Car occupant injured in transport accident
0.803 0.197 0.000
O94-O99 Other obstetric conditions, not elsewhere classified
0.802 0.198 0.000
G80 Infantile cerebral palsy
0.800 0.199 0.000
S01.8 Open wound of other parts of head
0.799 0.201 0.000
T84 Complications of internal orthopaedic prosthetic devices, implants and grafts
0.795 0.205 0.000
O00 Ectopic pregnancy
0.792 0.208 0.000
S05 Injury of eye and orbit
0.792 0.208 0.000
O42 Premature rupture of membranes
0.789 0.211 0.000
C78 Secondary malignant neoplasm of respiratory and digestive organs
0.789 0.211 0.000
Y90-Y98 Supplementary factors related to causes of morbidity and mortality classified elsewhere
0.787 0.213 0.000
H65-H75 Diseases of middle ear and mastoid
0.785 0.215 0.000
M54.4 Lumbago with sciatica
0.785 0.215 0.000
H33 Retinal detachments and breaks
0.784 0.216 0.000
M60-M63 Disorders of muscles
0.782 0.218 0.000
M86-M90 Other osteopathies
0.781 0.219 0.000
J32.4 Chronic pansinusitis
0.780 0.220 0.000
M54.9 Dorsalgia, unspecified
0.780 0.220 0.000
E00-E07 Disorders of thyroid gland
0.777 0.223 0.000
M47.97 Spondylosis, unspecified (Lumbosacral region)
0.775 0.225 0.000
O61 Failed induction of labour
0.774 0.226 0.000
T66-T78 Other and unspecified effects of external causes
0.773 0.227 0.000
M46 Other inflammatory spondylopathies
0.773 0.227 0.000
M54.39 Sciatica (Site unspecified)
0.772 0.228 0.000
T79-T79 Certain early complications of trauma
0.772 0.228 0.000
S90-S99 Injuries to the ankle and foot
0.772 0.228 0.000
E20-E35 Disorders of other endocrine glands
0.772 0.228 0.000
T85.5 Mechanical complication of gastro-intestinal prosthetic devices, implants and grafts
0.771 0.229 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.767 0.233 0.000
D37-D48 Neoplasms of uncertain or unknown behaviour
0.767 0.233 0.000
M54.64 Pain in thoracic spine (Thoracic region)
0.766 0.234 0.000
M47.87 Other spondylosis (Lumbosacral region)
0.765 0.234 0.000
T83 Complications of genito-urinary prosthetic devices, implants and grafts
0.764 0.235 0.000
O64.1 Obstructed labour due to breech presentation
0.764 0.236 0.000
T85.7 Infection and inflammatory reaction due to other internal prosthetic devices, implants and grafts
0.763 0.237 0.000
C81.1 Nodular sclerosis
0.763 0.237 0.000
S79 Other and unspecified injuries of hip and thigh
0.761 0.238 0.000
T47 Poisoning by agents primarily affecting gastro-intestinal system
0.760 0.240 0.000
J95-J99 Other diseases of the respiratory system
0.759 0.241 0.000
O68.9 Labour and delivery complicated by foetal stress, unspecified
0.759 0.241 0.000
S02 Fracture of skull and facial bones
0.759 0.241 0.000
O85-O92 Complications predominantly related to the puerperium
0.758 0.242 0.000
A30-A49 Other bacterial diseases
0.758 0.242 0.000
O72 Postpartum haemorrhage
0.757 0.243 0.000
T90.5 Sequelae of intracranial injury
0.756 0.244 0.000
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]
0.756 0.244 0.000
J38 Diseases of vocal cords and larynx, not elsewhere classified
0.754 0.246 0.000
Y85.9 Sequelae of other and unspecified transport accidents
0.752 0.248 0.000
M91-M94 Chondropathies
0.751 0.249 0.000
S06.50 Traumatic subdural haemorrhage (without open intracranial wound)
0.751 0.249 0.000
S72 Fracture of femur
0.751 0.249 0.000
M50.0 Cervical disk disorder with myelopathy
0.751 0.249 0.000
C07 Malignant neoplasm of parotid gland
0.750 0.250 0.000
O66 Other obstructed labour
0.750 0.250 0.000
G61 Inflammatory polyneuropathy
0.750 0.250 0.000
S01.0 Open wound of scalp
0.747 0.253 0.000
T84.0 Mechanical complication of internal joint prosthesis
0.747 0.253 0.000
S06.0 Concussion
0.746 0.253 0.000
M43 Other deforming dorsopathies
0.744 0.256 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.744 0.256 0.000
B15-B19 Viral hepatitis
0.743 0.257 0.000
U00-U49 Provisional assignment of new diseases of uncertain etiology or emergency use
0.743 0.257 0.000
G57 Mononeuropathies of lower limb
0.741 0.259 0.000
T91 Sequelae of injuries of neck and trunk
0.741 0.259 0.000
T93 Sequelae of injuries of lower limb
0.741 0.259 0.000
B34 Viral infection of unspecified site
0.740 0.260 0.000
C97-C97 Malignant neoplasms of independent (primary) multiple sites
0.740 0.260 0.000
G82.1 Spastic paraplegia
0.740 0.260 0.000
M47.2 Other spondylosis with radiculopathy
0.740 0.260 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.740 0.260 0.000
C84 Peripheral and cutaneous T-cell lymphomas
0.740 0.260 0.000
J30 Vasomotor and allergic rhinitis
0.740 0.260 0.000
G81 Hemiplegia
0.738 0.262 0.000
C01 Malignant neoplasm of base of tongue
0.738 0.262 0.000
G20 Parkinson's disease
0.735 0.265 0.000
J33.8 Other polyp of sinus
0.735 0.265 0.000
O62 Abnormalities of forces of labour
0.734 0.266 0.000
T85.6 Mechanical complication of other specified internal prosthetic devices, implants and grafts
0.734 0.266 0.000
M81 Osteoporosis without pathological fracture
0.734 0.266 0.000
A80-A89 Viral infections of the central nervous system
0.733 0.267 0.000
H43-H45 Disorders of vitreous body and globe
0.733 0.267 0.000
M48.06 Spinal stenosis (Lumbar region)
0.732 0.268 0.000
G82.5 Tetraplegia, unspecified
0.731 0.269 0.000
B50-B64 Protozoal diseases
0.731 0.269 0.000
S10-S19 Injuries to the neck
0.730 0.270 0.000
S06.30 Focal brain injury (without open intracranial wound)
0.728 0.272 0.000
H90-H95 Other disorders of ear
0.728 0.272 0.000
M84 Disorders of continuity of bone
0.728 0.272 0.000
S06.6 Traumatic subarachnoid haemorrhage
0.728 0.272 0.000
C82.9 Follicular non-Hodgkin's lymphoma, unspecified
0.727 0.273 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.727 0.273 0.000
E27 Other disorders of adrenal gland
0.726 0.274 0.000
M48.07 Spinal stenosis (Lumbosacral region)
0.725 0.275 0.000
H34 Retinal vascular occlusions
0.724 0.276 0.000
Y88.3 Sequelae of surgical and medical procedures as the cause of abnormal reaction of the patient or of later complication, without mention of misadventure at the time of the procedure
0.724 0.276 0.000
M47.80 Other spondylosis (Multiple sites in spine)
0.724 0.276 0.000
J32.2 Chronic ethmoidal sinusitis
0.723 0.277 0.000
S86 Injury of muscle and tendon at lower leg level
0.723 0.277 0.000
O02 Other abnormal products of conception
0.722 0.278 0.000
S32 Fracture of lumbar spine and pelvis
0.722 0.278 0.000
M47.82 Other spondylosis (Cervical region)
0.722 0.278 0.000
S01.1 Open wound of eyelid and periocular area
0.721 0.279 0.000
X10-X19 Contact with heat and hot substances
0.721 0.279 0.000
M47.1 Other spondylosis with myelopathy
0.720 0.280 0.000
S00.5 Superficial injury of lip and oral cavity
0.720 0.280 0.000
B35 Dermatophytosis
0.719 0.281 0.000
C69-C72 Malignant neoplasms of eye, brain and other parts of central nervous system
0.718 0.282 0.000
H49-H52 Disorders of ocular muscles, binocular movement, accommodation and refraction
0.718 0.282 0.000
T33-T35 Frostbite
0.717 0.283 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.717 0.283 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.717 0.283 0.000
T00-T07 Injuries involving multiple body regions
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
G50 Disorders of trigeminal nerve
0.717 0.283 0.000
M54.8 Other dorsalgia
0.716 0.283 0.000
M54.0 Panniculitis affecting regions of neck and back
0.716 0.283 0.000
S06.20 Diffuse brain injury (without open intracranial wound)
0.716 0.284 0.000
B20-B24 Human immunodeficiency virus [HIV] disease
0.716 0.284 0.000
M49 Spondylopathies in diseases classified elsewhere
0.716 0.284 0.000
S06.8 Other intracranial injuries
0.715 0.284 0.000
C82.7 Other types of follicular non-Hodgkin's lymphoma
0.715 0.285 0.000
S08 Traumatic amputation of part of head
0.715 0.285 0.000
S07 Crushing injury of head
0.715 0.285 0.000
S04 Injury of cranial nerves
0.715 0.285 0.000
S03 Dislocation, sprain and strain of joints and ligaments of head
0.715 0.285 0.000
C12 Malignant neoplasm of pyriform sinus
0.714 0.286 0.000
C81.9 Hodgkin's disease, unspecified
0.714 0.286 0.000
S36 Injury of intra-abdominal organs
0.713 0.287 0.000
G99 Other disorders of nervous system in diseases classified elsewhere
0.712 0.288 0.000
S30 Superficial injury of abdomen, lower back and pelvis
0.712 0.288 0.000
T86 Failure and rejection of transplanted organs and tissues
0.711 0.288 0.000
M47.90 Spondylosis, unspecified (Multiple sites in spine)
0.711 0.289 0.000
M80 Osteoporosis with pathological fracture
0.710 0.290 0.000
O16 Unspecified maternal hypertension
0.710 0.290 0.000
O00.1 Tubal pregnancy
0.710 0.290 0.000
S81 Open wound of lower leg
0.710 0.290 0.000
M48.56 Collapsed vertebra, not elsewhere classified (Lumbar region)
0.709 0.291 0.000
H33.0 Retinal detachment with retinal break
0.709 0.291 0.000
T85.8 Other complications of internal prosthetic devices, implants and grafts, not elsewhere classified
0.708 0.292 0.000
M70-M79 Other soft tissue disorders
0.707 0.293 0.000
G70-G73 Diseases of myoneural junction and muscle
0.706 0.294 0.000
O10 Pre-existing hypertension complicating pregnancy, childbirth and the puerperium
0.704 0.296 0.000
S51 Open wound of forearm
0.704 0.296 0.000
M48.02 Spinal stenosis (Cervical region)
0.704 0.296 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.703 0.297 0.000
O69 Labour and delivery complicated by umbilical cord complications
0.702 0.298 0.000
S27 Injury of other and unspecified intrathoracic organs
0.702 0.298 0.000
Y83-Y84 Surgical and other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
0.701 0.299 0.000
G61.0 Guillain-Barre syndrome
0.701 0.299 0.000
G24 Dystonia
0.701 0.299 0.000
X58-X59 Accidental exposure to other and unspecified factors
0.701 0.299 0.000
J31 Chronic rhinitis, nasopharyngitis and pharyngitis
0.700 0.300 0.000
E03 Other hypothyroidism
0.700 0.300 0.000
M54.37 Sciatica (Lumbosacral region)
0.699 0.301 0.000
C73 Malignant neoplasm of thyroid gland
0.699 0.301 0.000
S06.9 Intracranial injury, unspecified
0.699 0.301 0.000
S06.7 Intracranial injury with prolonged coma
0.699 0.301 0.000
S06.1 Traumatic cerebral oedema
0.699 0.301 0.000
M54.55 Low back pain (Thoracolumbar region)
0.698 0.301 0.000
M54.54 Low back pain-Thoracic
0.698 0.301 0.000
M54.53 Low back pain-Cervicothoracic
0.698 0.301 0.000
M54.52 Low back pain-Cervical
0.698 0.301 0.000
M54.51 Low back pain-Occipit-atl-axl
0.698 0.301 0.000
O47 False labour
0.698 0.302 0.000
H71 Cholesteatoma of middle ear
0.697 0.303 0.000
M47.0 Anterior spinal and vertebral artery compression syndromes
0.695 0.305 0.000
M50.2 Other cervical disk displacement
0.695 0.305 0.000
V49 Car occupant injured in other and unspecified transport accidents
0.694 0.306 0.000
S39 Other and unspecified injuries of abdomen, lower back and pelvis
0.693 0.307 0.000
X60-X84 Intentional self-harm
0.693 0.307 0.000
M53 Other dorsopathies, not elsewhere classified
0.693 0.307 0.000
O75 Other complications of labour and delivery, not elsewhere classified
0.691 0.309 0.000
M54.28 Cervicalgia-Sacral/sacrococ
0.690 0.310 0.000
M54.27 Cervicalgia-Lumbosacral
0.690 0.310 0.000
M54.26 Cervicalgia-Lumbar
0.690 0.310 0.000
M54.25 Cervicalgia-Thoracolumbar
0.690 0.310 0.000
M54.24 Cervicalgia-Thoracic
0.690 0.310 0.000
M54.23 Cervicalgia (Cervicothoracic region)
0.690 0.310 0.000
M54.21 Cervicalgia (Occipito-atlanto-axial region)
0.690 0.310 0.000
M54.20 Cervicalgia-Mult site
0.690 0.310 0.000
W50-W64 Exposure to animate mechanical forces
0.690 0.310 0.000
J85-J86 Suppurative and necrotic conditions of lower respiratory tract
0.690 0.310 0.000
M00-M03 Infectious arthropathies
0.690 0.310 0.000
H72 Perforation of tympanic membrane
0.689 0.311 0.000
T82.1 Mechanical complication of cardiac electronic device
0.689 0.311 0.000
G80.9 Infantile cerebral palsy, unspecified
0.687 0.312 0.000
B37.8 Candidiasis of other sites
0.687 0.313 0.000
G09 Sequelae of inflammatory diseases of central nervous system
0.686 0.313 0.000
B65-B83 Helminthiases
0.686 0.314 0.000
M47.86 Other spondylosis (Lumbar region)
0.686 0.314 0.000
O40 Polyhydramnios
0.686 0.314 0.000
G00 Bacterial meningitis, not elsewhere classified
0.686 0.314 0.000
Y35-Y36 Legal intervention and operations of war
0.685 0.315 0.000
Y10-Y34 Event of undetermined intent
0.685 0.315 0.000
Y00-Y09 Assault
0.685 0.315 0.000
X85-X99 Assault
0.685 0.315 0.000
X50-X57 Overexertion, travel and privation
0.685 0.315 0.000
X30-X39 Exposure to forces of nature
0.685 0.315 0.000
X00-X09 Exposure to smoke, fire and flames
0.685 0.315 0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure
0.685 0.315 0.000
W75-W84 Other accidental threats to breathing
0.685 0.315 0.000
W65-W74 Accidental drowning and submersion
0.685 0.315 0.000
V98-V99 Other and unspecified transport accidents
0.685 0.315 0.000
V95-V97 Air and space transport accidents
0.685 0.315 0.000
V90-V94 Water transport accidents
0.685 0.315 0.000
V70-V79 Bus occupant injured in transport accident
0.685 0.315 0.000
V60-V69 Occupant of heavy transport vehicle injured in transport accident
0.685 0.315 0.000
V50-V59 Occupant of pick-up truck or van injured in transport accident
0.685 0.315 0.000
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident
0.685 0.315 0.000
V01-V09 Pedestrian injured in transport accident
0.685 0.315 0.000
T46.6 Antihyperlipidaemic and antiarteriosclerotic drugs
0.684 0.316 0.000
J80-J84 Other respiratory diseases principally affecting the interstitium
0.683 0.317 0.000
J67 Hypersensitivity pneumonitis due to organic dust
0.683 0.317 0.000
S06.40 Epidural haemorrhage (without open intracranial wound)
0.683 0.317 0.000
O74 Complications of anaesthesia during labour and delivery
0.682 0.318 0.000
O71 Other obstetric trauma
0.682 0.318 0.000
O65 Obstructed labour due to maternal pelvic abnormality
0.682 0.318 0.000
O60 Preterm delivery
0.682 0.318 0.000
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs
0.682 0.318 0.000
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system
0.682 0.318 0.000
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified
0.682 0.318 0.000
T41 Poisoning by anaesthetics and therapeutic gases
0.682 0.318 0.000
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.682 0.318 0.000
T37 Poisoning by other systemic anti-infectives and antiparasitics
0.682 0.318 0.000
T36 Poisoning by systemic antibiotics
0.682 0.318 0.000
C78.5 Secondary malignant neoplasm of large intestine and rectum
0.682 0.318 0.000
M54.29 Cervicalgia-Site unspe
0.682 0.318 0.000
O12 Gestational [pregnancy-induced] oedema and proteinuria without hypertension
0.682 0.318 0.000
M51.3 Other specified intervertebral disk degeneration
0.682 0.318 0.000
M51.1 Lumbar and other intervertebral disk disorders with radiculopathy
0.682 0.318 0.000
M51.4 Schmorl's nodes
0.682 0.318 0.000
J38.4 Oedema of larynx
0.681 0.318 0.000
S73 Dislocation, sprain and strain of joint and ligaments of hip
0.681 0.319 0.000
B34.9 Viral infection, unspecified
0.681 0.319 0.000
S00.1 Contusion of eyelid and periocular area
0.681 0.319 0.000
C40-C41 Malignant neoplasms of bone and articular cartilage
0.681 0.319 0.000
E07 Other disorders of thyroid
0.681 0.319 0.000
T85.2 Mechanical complication of intraocular lens
0.680 0.320 0.000
H33.2 Serous retinal detachment
0.680 0.320 0.000
O67 Labour and delivery complicated by intrapartum haemorrhage, not elsewhere classified
0.680 0.320 0.000
S00.3 Superficial injury of nose
0.680 0.320 0.000
D00-D09 In situ neoplasms
0.680 0.320 0.000
J60 Coalworker's pneumoconiosis
0.679 0.321 0.000
S20 Superficial injury of thorax
0.679 0.321 0.000
B44 Aspergillosis
0.678 0.321 0.000
T84.8 Other complications of internal orthopaedic prosthetic devices, implants and grafts
0.678 0.322 0.000
J32.0 Chronic maxillary sinusitis
0.678 0.322 0.000
B99-B99 Other infectious diseases
0.678 0.322 0.000
B90-B94 Sequelae of infectious and parasitic diseases
0.678 0.322 0.000
B85-B89 Pediculosis, acariasis and other infestations
0.678 0.322 0.000
A92-A99 Arthropod-borne viral fevers and viral haemorrhagic fevers
0.678 0.322 0.000
A75-A79 Rickettsioses
0.678 0.322 0.000
A70-A74 Other diseases caused by chlamydiae
0.678 0.322 0.000
A65-A69 Other spirochaetal diseases
0.678 0.322 0.000
A20-A28 Certain zoonotic bacterial diseases
0.678 0.322 0.000
A15-A19 Tuberculosis
0.678 0.322 0.000
G53 Cranial nerve disorders in diseases classified elsewhere
0.678 0.322 0.000
X40-X49 Accidental poisoning by and exposure to noxious substances
0.677 0.322 0.000
M48.9 Spondylopathy, unspecified
0.677 0.323 0.000
M48.8 Other specified spondylopathies
0.677 0.323 0.000
M48.4 Fatigue fracture of vertebra
0.677 0.323 0.000
M48.3 Traumatic spondylopathy
0.677 0.323 0.000
M48.2 Kissing spine
0.677 0.323 0.000
M48.1 Ankylosing hyperostosis [Forestier]
0.677 0.323 0.000
S01.7 Multiple open wounds of head
0.677 0.323 0.000
J37 Chronic laryngitis and laryngotracheitis
0.676 0.324 0.000
C78.8 Secondary malignant neoplasm of other and unspecified digestive organs
0.675 0.325 0.000
C96 Other and unspecified malignant neoplasms of lymphoid, haematopoietic and related tissue
0.675 0.325 0.000
C95 Leukaemia of unspecified cell type
0.675 0.325 0.000
C94 Other leukaemias of specified cell type
0.675 0.325 0.000
C93 Monocytic leukaemia
0.675 0.325 0.000
C88 Malignant immunoproliferative diseases
0.675 0.325 0.000
C86 Other specified types of T/NK-cell lymphoma
0.675 0.325 0.000
G58 Other mononeuropathies
0.675 0.325 0.000
X20-X29 Contact with venomous animals and plants
0.674 0.326 0.000
C78.2 Secondary malignant neoplasm of pleura
0.674 0.326 0.000
T39.1 4-Aminophenol derivatives
0.673 0.327 0.000
O42.9 Premature rupture of membranes, unspecified
0.673 0.327 0.000
O44 Placenta praevia
0.671 0.329 0.000
M47.96 Spondylosis, unspecified (Lumbar region)
0.671 0.329 0.000
H93 Other disorders of ear, not elsewhere classified
0.671 0.329 0.000
U80 Agent resistant to penicillin and related antibiotics
0.670 0.330 0.000
V20-V29 Motorcycle rider injured in transport accident
0.668 0.332 0.000
H60-H62 Diseases of external ear
0.667 0.333 0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use
0.667 0.333 0.000
O73 Retained placenta and membranes, without haemorrhage
0.667 0.333 0.000
Y95 Nosocomial condition
0.667 0.333 0.000
H15-H22 Disorders of sclera, cornea, iris and ciliary body
0.666 0.334 0.000
G90 Disorders of autonomic nervous system
0.664 0.336 0.000
C45-C49 Malignant neoplasms of mesothelial and soft tissue
0.664 0.336 0.000
O41 Other disorders of amniotic fluid and membranes
0.664 0.336 0.000
O99 Other maternal diseases classifiable elsewhere but complicating pregnancy, childbirth and the puerperium
0.664 0.336 0.000
T87 Complications peculiar to reattachment and amputation
0.664 0.336 0.000
T95 Sequelae of burns, corrosions and frostbite
0.664 0.336 0.000
T94 Sequelae of injuries involving multiple and unspecified body regions
0.664 0.336 0.000
T97 Sequelae of toxic effects of substances chiefly nonmedicinal as to source
0.664 0.336 0.000
T96 Sequelae of poisoning by drugs, medicaments and biological substances
0.664 0.336 0.000
T98 Sequelae of other and unspecified effects of external causes
0.664 0.336 0.000
T85.4 Mechanical complication of breast prosthesis and implant
0.664 0.336 0.000
O68.8 Labour and delivery complicated by other evidence of foetal stress
0.664 0.336 0.000
O15 Eclampsia
0.663 0.337 0.000
O11 Pre-existing hypertensive disorder with superimposed proteinuria
0.663 0.337 0.000
B37.3 Candidiasis of vulva and vagina
0.663 0.337 0.000
Y89 Sequelae of other external causes
0.662 0.338 0.000
Y87 Sequelae of intentional self-harm, assault and events of undetermined intent
0.662 0.338 0.000
M50.3 Other cervical disk degeneration
0.662 0.338 0.000
O04 Medical abortion
0.661 0.339 0.000
S79.9 Unspecified injury of hip and thigh
0.661 0.339 0.000
J36 Peritonsillar abscess
0.660 0.339 0.000
G82.4 Spastic tetraplegia
0.660 0.340 0.000
G82.3 Flaccid tetraplegia
0.660 0.340 0.000
G82.0 Flaccid paraplegia
0.660 0.340 0.000
W00-W19 Falls
0.659 0.341 0.000
C92 Myeloid leukaemia
0.659 0.341 0.000
B37.1 Pulmonary candidiasis
0.659 0.341 0.000
M47.99 Spondylosis, unspecified (Site unspecified)
0.659 0.341 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.659 0.341 0.000
C76 Malignant neoplasm of other and ill-defined sites
0.659 0.341 0.000
J18 Pneumonia, organism unspecified
0.658 0.342 0.000
M54.50 Low back pain (Multiple sites in spine)
0.658 0.342 0.000
S02.6 Fracture of mandible
0.657 0.343 0.000
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)
0.657 0.343 0.000
M45.X7 Ankylosing spondylitis (Lumbosacral region)
0.657 0.343 0.000
M45.X6 Ankylosing spondylitis (Lumbar region)
0.657 0.343 0.000
M45.X5 Ankylosing spondylitis (Thoracolumbar region)
0.657 0.343 0.000
M45.X4 Ankylosing spondylitis (Thoracic region)
0.657 0.343 0.000
M45.X3 Ankylosing spondylitis (Cervicothoracic region)
0.657 0.343 0.000
M45.X2 Ankylosing spondylitis (Cervical region)
0.657 0.343 0.000
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)
0.657 0.343 0.000
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.657 0.343 0.000
S88 Traumatic amputation of lower leg
0.657 0.343 0.000
S87 Crushing injury of lower leg
0.657 0.343 0.000
S85 Injury of blood vessels at lower leg level
0.657 0.343 0.000
S84 Injury of nerves at lower leg level
0.657 0.343 0.000
M48.00 Spinal stenosis (Multiple sites in spine)
0.656 0.344 0.000
J33.1 Polypoid sinus degeneration
0.656 0.344 0.000
G11 Hereditary ataxia
0.656 0.344 0.000
J39 Other diseases of upper respiratory tract
0.655 0.345 0.000
S70 Superficial injury of hip and thigh
0.654 0.346 0.000
J32.8 Other chronic sinusitis
0.654 0.346 0.000
S89 Other and unspecified injuries of lower leg
0.653 0.347 0.000
E22 Hyperfunction of pituitary gland
0.653 0.347 0.000
M40 Kyphosis and lordosis
0.653 0.347 0.000
J32.3 Chronic sphenoidal sinusitis
0.653 0.347 0.000
J32.1 Chronic frontal sinusitis
0.653 0.347 0.000
G51 Facial nerve disorders
0.651 0.349 0.000
H34.8 Other retinal vascular occlusions
0.650 0.350 0.000
S00.0 Superficial injury of scalp
0.649 0.351 0.000
C85.7 Other specified types of non-Hodgkin's lymphoma
0.649 0.351 0.000
C85.2 Mediastinal (thymic) large B-cell lymphoma
0.649 0.351 0.000
C85.0 Lymphosarcoma
0.649 0.351 0.000
M54.36 Sciatica (Lumbar region)
0.648 0.352 0.000
J15 Bacterial pneumonia, not elsewhere classified
0.648 0.352 0.000
O45 Premature separation of placenta [abruptio placentae]
0.648 0.352 0.000
O33 Maternal care for known or suspected disproportion
0.648 0.352 0.000
O31 Complications specific to multiple gestation
0.648 0.352 0.000
J33.0 Polyp of nasal cavity
0.648 0.352 0.000
B00-B09 Viral infections characterized by skin and mucous membrane lesions
0.647 0.353 0.000
T93.3 Sequelae of dislocation, sprain and strain of lower limb
0.647 0.353 0.000
S78 Traumatic amputation of hip and thigh
0.647 0.353 0.000
S77 Crushing injury of hip and thigh
0.647 0.353 0.000
S76 Injury of muscle and tendon at hip and thigh level
0.647 0.353 0.000
S75 Injury of blood vessels at hip and thigh level
0.647 0.353 0.000
S74 Injury of nerves at hip and thigh level
0.647 0.353 0.000
S71 Open wound of hip and thigh
0.647 0.353 0.000
O61.0 Failed medical induction of labour
0.647 0.353 0.000
G12 Spinal muscular atrophy and related syndromes
0.646 0.354 0.000
D48 Neoplasm of uncertain or unknown behaviour of other and unspecified sites
0.645 0.355 0.000
T43 Poisoning by psychotropic drugs, not elsewhere classified
0.644 0.356 0.000
O35 Maternal care for known or suspected foetal abnormality and damage
0.644 0.356 0.000
S38 Crushing injury and traumatic amputation of part of abdomen, lower back and pelvis
0.643 0.357 0.000
S37 Injury of urinary and pelvic organs
0.643 0.357 0.000
S35 Injury of blood vessels at abdomen, lower back and pelvis level
0.643 0.357 0.000
S34 Injury of nerves and lumbar spinal cord at abdomen, lower back and pelvis level
0.643 0.357 0.000
S33 Dislocation, sprain and strain of joints and ligaments of lumbar spine and pelvis
0.643 0.357 0.000
S31 Open wound of abdomen, lower back and pelvis
0.643 0.357 0.000
Y60-Y69 Misadventures to patients during surgical and medical care
0.643 0.357 0.000
M82 Osteoporosis in diseases classified elsewhere
0.643 0.357 0.000
T85.9 Unspecified complication of internal prosthetic device, implant and graft
0.643 0.357 0.000
T85.1 Mechanical complication of implanted electronic stimulator of nervous system
0.643 0.357 0.000
T85.0 Mechanical complication of ventricular intracranial (communicating) shunt
0.643 0.357 0.000
E03.9 Hypothyroidism, unspecified
0.642 0.358 0.000
S29 Other and unspecified injuries of thorax
0.642 0.358 0.000
T46.4 Angiotensin-converting-enzyme inhibitors
0.642 0.358 0.000
S83 Dislocation, sprain and strain of joints and ligaments of knee
0.641 0.359 0.000
M47.88 Other spondylosis (Sacral and sacrococcygeal region)
0.641 0.359 0.000
M47.85 Other spondylosis (Thoracolumbar region)
0.641 0.359 0.000
M47.84 Other spondylosis (Thoracic region)
0.641 0.359 0.000
M47.83 Other spondylosis (Cervicothoracic region)
0.641 0.359 0.000
M47.81 Other spondylosis (Occipito-atlanto-axial region)
0.641 0.359 0.000
M43.0 Spondylolysis
0.641 0.359 0.000
T44 Poisoning by drugs primarily affecting the autonomic nervous system
0.641 0.359 0.000
C02 Malignant neoplasm of other and unspecified parts of tongue
0.641 0.359 0.000
T39.9 Nonopioid analgesic, antipyretic and antirheumatic, unspecified
0.640 0.360 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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