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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs116442786
log Bayes Factor = 21.1223
Chromosome 6   position 31,321,336  (GRCh37) Explore rs116442786 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
1.000 0.000 0.000
K90.0 Coeliac disease
0.000 0.000 1.000
E03 Other hypothyroidism
0.842 0.156 0.001
E00-E07 Disorders of thyroid gland
0.729 0.267 0.003
J45.9 Asthma, unspecified
0.000 0.295 0.705
E06 Thyroiditis
0.691 0.308 0.001
E10.9 Without complications
0.000 0.354 0.646
E07 Other disorders of thyroid
0.631 0.367 0.002
E10 Insulin-dependent diabetes mellitus
0.000 0.369 0.631
K90 Intestinal malabsorption
0.000 0.371 0.629
E06.3 Autoimmune thyroiditis
0.613 0.387 0.000
E03.8 Other specified hypothyroidism
0.604 0.395 0.001
E03.5 Myxoedema coma
0.604 0.395 0.001
E03.4 Atrophy of thyroid (acquired)
0.604 0.395 0.001
E03.3 Postinfectious hypothyroidism
0.604 0.395 0.001
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.604 0.395 0.001
E03.1 Congenital hypothyroidism without goitre
0.604 0.395 0.001
E03.0 Congenital hypothyroidism with diffuse goitre
0.604 0.395 0.001
E06.1 Subacute thyroiditis
0.593 0.407 0.001
E10.3 With ophthalmic complications
0.000 0.413 0.587
E07.9 Disorder of thyroid, unspecified
0.561 0.439 0.001
E06.9 Thyroiditis, unspecified
0.552 0.447 0.001
E10-E14 Diabetes mellitus
0.000 0.459 0.541
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.523 0.475 0.002
E00 Congenital iodine-deficiency syndrome
0.523 0.475 0.002
E02 Subclinical iodine-deficiency hypothyroidism
0.523 0.475 0.002
E05 Thyrotoxicosis [hyperthyroidism]
0.514 0.485 0.002
E10.1 With ketoacidosis
0.000 0.493 0.507
E06.5 Other chronic thyroiditis
0.495 0.504 0.001
E06.4 Drug-induced thyroiditis
0.495 0.504 0.001
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.495 0.504 0.001
E06.0 Acute thyroiditis
0.495 0.504 0.001
E14 Unspecified diabetes mellitus
0.000 0.513 0.487
E10.4 With neurological complications
0.000 0.518 0.482
E10.2 With renal complications
0.000 0.531 0.469
E07.8 Other specified disorders of thyroid
0.452 0.546 0.001
E07.1 Dyshormogenetic goitre
0.452 0.546 0.001
E07.0 Hypersecretion of calcitonin
0.452 0.546 0.001
E10.8 With unspecified complications
0.000 0.548 0.452
E10.7 With multiple complications
0.000 0.548 0.452
E10.6 With other specified complications
0.000 0.548 0.452
E10.0 With coma
0.000 0.548 0.452
K90.8 Other intestinal malabsorption
0.000 0.549 0.451
K90.3 Pancreatic steatorrhoea
0.000 0.549 0.451
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.549 0.451
K90.1 Tropical sprue
0.000 0.549 0.451
E10.5 With peripheral circulatory complications
0.000 0.553 0.447
K90.9 Intestinal malabsorption, unspecified
0.000 0.563 0.437
E11 Non-insulin-dependent diabetes mellitus
0.000 0.568 0.432
E14.3 With ophthalmic complications
0.000 0.570 0.430
K90-K93 Other diseases of the digestive system
0.000 0.570 0.430
E05.9 Thyrotoxicosis, unspecified
0.428 0.571 0.000
E04 Other non-toxic goitre
0.427 0.572 0.001
J45 Asthma
0.000 0.580 0.419
E13 Other specified diabetes mellitus
0.000 0.581 0.418
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.591 0.409
E14.9 Without complications
0.000 0.604 0.396
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.392 0.607 0.001
E12 Malnutrition-related diabetes mellitus
0.000 0.612 0.388
K92 Other diseases of digestive system
0.000 0.613 0.387
K92.1 Melaena
0.000 0.614 0.386
E11.4 With neurological complications
0.000 0.617 0.383
E11.3 With ophthalmic complications
0.000 0.622 0.378
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.375 0.623 0.002
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.375 0.623 0.002
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.375 0.623 0.002
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.375 0.623 0.002
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.375 0.623 0.002
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.375 0.623 0.002
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.375 0.623 0.002
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.375 0.623 0.002
E05.8 Other thyrotoxicosis
0.368 0.630 0.001
E05.5 Thyroid crisis or storm
0.368 0.630 0.001
E05.4 Thyrotoxicosis factitia
0.368 0.630 0.001
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.368 0.630 0.001
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.368 0.630 0.001
E11.1 With ketoacidosis
0.000 0.634 0.366
J45.0 Predominantly allergic asthma
0.000 0.642 0.358
C82.9 Follicular non-Hodgkin's lymphoma, unspecified
0.355 0.645 0.000
E14.8 With unspecified complications
0.000 0.650 0.349
E14.7 With multiple complications
0.000 0.650 0.349
E14.6 With other specified complications
0.000 0.650 0.349
E14.5 With peripheral circulatory complications
0.000 0.650 0.349
E14.4 With neurological complications
0.000 0.650 0.349
E14.2 Withrenal complications
0.000 0.650 0.349
E14.1 With ketoacidosis
0.000 0.650 0.349
E14.0 With coma
0.000 0.650 0.349
E11.5 With peripheral circulatory complications
0.000 0.662 0.338
C82 Follicular [nodular] non-Hodgkin's lymphoma
0.332 0.668 0.000
E13.9 Without complications
0.000 0.669 0.330
E04.2 Non-toxic multinodular goitre
0.320 0.679 0.000
K91 Postprocedural disorders of digestive system, not elsewhere classified
0.000 0.685 0.315
E11.7 With multiple complications
0.000 0.690 0.310
K93 Disorders of other digestive organs in diseases classified elsewhere
0.000 0.692 0.308
E04.8 Other specified non-toxic goitre
0.306 0.693 0.001
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue
0.303 0.697 0.000
J45.8 Mixed asthma
0.000 0.699 0.301
J45.1 Nonallergic asthma
0.000 0.699 0.301
E13.8 With unspecified complications
0.000 0.700 0.300
E13.7 With multiple complications
0.000 0.700 0.300
E13.6 With other specified complications
0.000 0.700 0.300
E13.5 With peripheral circulatory complications
0.000 0.700 0.300
E13.4 With neurological complications
0.000 0.700 0.300
E13.3 With ophthalmic complications
0.000 0.700 0.300
E13.2 With renal complications
0.000 0.700 0.300
E13.1 With ketoacidosis
0.000 0.700 0.300
E13.0 With coma
0.000 0.700 0.300
C85 Other and unspecified types of non-Hodgkin's lymphoma
0.299 0.701 0.000
K91.3 Postoperative intestinal obstruction
0.000 0.707 0.293
E11.8 With unspecified complications
0.000 0.707 0.293
C85.9 Non-Hodgkin's lymphoma, unspecified type
0.293 0.707 0.000
E11.2 With renal complications
0.000 0.713 0.287
E04.9 Non-toxic goitre, unspecified
0.286 0.714 0.001
C83 Diffuse non-Hodgkin's lymphoma
0.279 0.721 0.000
E04.0 Non-toxic diffuse goitre
0.278 0.721 0.001
E12.9 Without complications
0.000 0.722 0.278
E12.8 With unspecified complications
0.000 0.722 0.278
E12.7 With multiple complications
0.000 0.722 0.278
E12.6 With other specified complications
0.000 0.722 0.278
E12.5 With peripheral circulatory complications
0.000 0.722 0.278
E12.4 With neurological complications
0.000 0.722 0.278
E12.3 With ophthalmic complications
0.000 0.722 0.278
E12.2 With renal complications
0.000 0.722 0.278
E12.1 With ketoacidosis
0.000 0.722 0.278
E12.0 With coma
0.000 0.722 0.278
E11.6 With other specified complications
0.000 0.724 0.276
E11.0 With coma
0.000 0.737 0.263
C82.0 Small cleaved cell, follicular
0.260 0.740 0.000
E04.1 Non-toxic single thyroid nodule
0.258 0.741 0.001
C82.1 Mixed small cleaved and large cell, follicular
0.258 0.742 0.000
C81 Hodgkin's disease
0.258 0.742 0.000
C83.3 Large cell (diffuse)
0.249 0.751 0.000
C82.7 Other types of follicular non-Hodgkin's lymphoma
0.246 0.754 0.000
C85.1 B-cell lymphoma, unspecified
0.244 0.756 0.000
K92.8 Other specified diseases of digestive system
0.000 0.756 0.243
C82.6 Cutaneous follicle centre lymphoma
0.238 0.762 0.000
C82.5 Diffuse follicle centre lymphoma
0.238 0.762 0.000
C82.4 Follicular lymphoma grade IIIb
0.238 0.762 0.000
C82.3 Follicular lymphoma grade IIIa
0.238 0.762 0.000
C82.2 Large cell, follicular
0.238 0.762 0.000
K92.9 Disease of digestive system, unspecified
0.000 0.762 0.238
C83.9 Diffuse non-Hodgkin's lymphoma, unspecified
0.232 0.768 0.000
C85.7 Other specified types of non-Hodgkin's lymphoma
0.228 0.771 0.000
K91.9 Postprocedural disorder of digestive system, unspecified
0.000 0.774 0.226
K91.5 Postcholecystectomy syndrome
0.000 0.774 0.226
K91.2 Postsurgical malabsorption, not elsewhere classified
0.000 0.774 0.226
C81.9 Hodgkin's disease, unspecified
0.226 0.774 0.000
K91.0 Vomiting following gastro-intestinal surgery
0.000 0.775 0.225
Chapter IV Endocrine, nutritional and metabolic diseases
0.011 0.776 0.213
K93.8 Disorders of other specified digestive organs in diseases classified elsewhere
0.000 0.779 0.221
K93.1 Megacolon in Chagas' disease
0.000 0.779 0.221
K93.0 Tuberculous disorders of intestines, peritoneum and mesenteric glands
0.000 0.779 0.221
C96 Other and unspecified malignant neoplasms of lymphoid, haematopoietic and related tissue
0.218 0.782 0.000
C95 Leukaemia of unspecified cell type
0.218 0.782 0.000
C94 Other leukaemias of specified cell type
0.218 0.782 0.000
C93 Monocytic leukaemia
0.218 0.782 0.000
C86 Other specified types of T/NK-cell lymphoma
0.218 0.782 0.000
C84 Peripheral and cutaneous T-cell lymphomas
0.217 0.783 0.000
C85.2 Mediastinal (thymic) large B-cell lymphoma
0.215 0.785 0.000
C85.0 Lymphosarcoma
0.215 0.785 0.000
C88 Malignant immunoproliferative diseases
0.213 0.787 0.000
K91.4 Colostomy and enterostomy malfunction
0.000 0.788 0.212
K92.2 Gastro-intestinal haemorrhage, unspecified
0.000 0.790 0.210
E05.0 Thyrotoxicosis with diffuse goitre
0.202 0.796 0.002
C83.1 Small cleaved cell (diffuse)
0.203 0.797 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.006 0.797 0.197
C83.8 Other types of diffuse non-Hodgkin's lymphoma
0.201 0.799 0.000
C83.7 Burkitt's tumour
0.200 0.800 0.000
C83.6 Undifferentiated (diffuse)
0.200 0.800 0.000
C83.5 Lymphoblastic (diffuse)
0.200 0.800 0.000
C83.4 Immunoblastic (diffuse)
0.200 0.800 0.000
C83.2 Mixed small and large cell (diffuse)
0.200 0.800 0.000
C83.0 Small cell (diffuse)
0.200 0.800 0.000
K91.1 Postgastric surgery syndromes
0.000 0.806 0.193
E50-E64 Other nutritional deficiencies
0.005 0.811 0.184
E16 Other disorders of pancreatic internal secretion
0.003 0.812 0.185
C81.7 Other Hodgkin's disease
0.185 0.815 0.000
C81.4 Lymphocyte-rich classical Hodgkin lymphoma
0.185 0.815 0.000
C81.3 Lymphocytic depletion
0.185 0.815 0.000
C81.2 Mixed cellularity
0.185 0.815 0.000
C81.0 Lymphocytic predominance
0.185 0.815 0.000
C81.1 Nodular sclerosis
0.182 0.818 0.000
E16.2 Hypoglycaemia, unspecified
0.000 0.822 0.177
C92 Myeloid leukaemia
0.163 0.836 0.000
E53 Deficiency of other B group vitamins
0.003 0.838 0.160
E20-E35 Disorders of other endocrine glands
0.004 0.839 0.157
E40-E46 Malnutrition
0.007 0.843 0.150
C86.6 Primary cutaneous CD30-positive T-cell proliferations
0.156 0.844 0.000
C86.5 Angioimmunoblastic T-cell lymphoma
0.156 0.844 0.000
C86.4 Blastic NK-cell lymphoma
0.156 0.844 0.000
C86.3 Subcutaneous panniculitis-like T-cell lymphoma
0.156 0.844 0.000
C86.2 Enteropathy-type (intestinal) T-cell lymphoma
0.156 0.844 0.000
C86.1 Hepatosplenic T-cell lymphoma
0.156 0.844 0.000
C86.0 Extranodal NK/T-cell lymphoma, nasal type
0.156 0.844 0.000
C93.9 Monocytic leukaemia, unspecified
0.156 0.844 0.000
C93.7 Other monocytic leukaemia
0.156 0.844 0.000
C93.3 Juvenile myelomonocytic leukaemia
0.156 0.844 0.000
C93.2 Subacute monocytic leukaemia
0.156 0.844 0.000
C93.1 Chronic monocytic leukaemia
0.156 0.844 0.000
C93.0 Acute monocytic leukaemia
0.156 0.844 0.000
C94.7 Other specified leukaemias
0.156 0.844 0.000
C94.6 Myelodysplastic and myeloproliferative disease, not elsewhere classified
0.156 0.844 0.000
C94.5 Acute myelofibrosis
0.156 0.844 0.000
C94.4 Acute panmyelosis
0.156 0.844 0.000
C94.3 Mast cell leukaemia
0.156 0.844 0.000
C94.2 Acute megakaryoblastic leukaemia
0.156 0.844 0.000
C94.1 Chronic erythraemia
0.156 0.844 0.000
C94.0 Acute erythraemia and erythroleukaemia
0.156 0.844 0.000
C95.9 Leukaemia, unspecified
0.156 0.844 0.000
C95.7 Other leukaemia of unspecified cell type
0.156 0.844 0.000
C95.2 Subacute leukaemia of unspecified cell type
0.156 0.844 0.000
C95.1 Chronic leukaemia of unspecified cell type
0.156 0.844 0.000
C95.0 Acute leukaemia of unspecified cell type
0.156 0.844 0.000
C96.9 Malignant neoplasms of lymphoid, haematopoietic and related tissue, unspecified
0.156 0.844 0.000
C96.8 Histiocytic sarcoma
0.156 0.844 0.000
C96.7 Other specified malignant neoplasms of lymphoid, haematopoietic and related tissue
0.156 0.844 0.000
C96.6 Unifocal Langerhans-cell histiocytosis
0.156 0.844 0.000
C96.5 Multifocal and unisystemic Langerhans-cell histiocytosis
0.156 0.844 0.000
C96.4 Sarcoma of dendritic cells (accessory cells)
0.156 0.844 0.000
C96.3 True histiocytic lymphoma
0.156 0.844 0.000
C96.2 Malignant mast cell tumour
0.156 0.844 0.000
C96.1 Malignant histiocytosis
0.156 0.844 0.000
C96.0 Letterer-Siwe disease
0.156 0.844 0.000
C84.9 Mature T/NK-cell lymphoma, unspecified
0.156 0.844 0.000
C84.8 Cutaneous T-cell lymphoma, unspecified
0.156 0.844 0.000
C84.7 Anaplastic large cell lymphoma, ALK-negative
0.156 0.844 0.000
C84.6 Anaplastic large cell lymphoma, ALK-positive
0.156 0.844 0.000
C84.4 Peripheral T-cell lymphoma
0.156 0.844 0.000
C84.3 Lymphoepithelioid lymphoma
0.156 0.844 0.000
C84.2 T-zone lymphoma
0.156 0.844 0.000
C84.1 Sezary's diease
0.156 0.844 0.000
C84.0 Mycosis fungoides
0.156 0.844 0.000
C84.5 Other and unspecified T-cell lymphomas
0.155 0.845 0.000
E55 Vitamin D deficiency
0.003 0.846 0.151
C88.9 Malignant immunoproliferative disease, unspecified
0.153 0.847 0.000
C88.7 Other malignant immunoproliferative diseases
0.153 0.847 0.000
C88.4 Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue [MALT-lymphoma]
0.153 0.847 0.000
C88.3 Immunoproliferative small intestinal disease
0.153 0.847 0.000
C88.2 Gamma heavy chain disease
0.153 0.847 0.000
C88.1 Alpha heavy chain disease
0.153 0.847 0.000
C91 Lymphoid leukaemia
0.152 0.847 0.000
C88.0 Waldenstrom's macroglobulinaemia
0.148 0.852 0.000
E15 Nondiabetic hypoglycaemic coma
0.004 0.854 0.141
E53.8 Deficiency of other specified B group vitamins
0.001 0.857 0.143
E29 Testicular dysfunction
0.002 0.863 0.135
E64 Sequelae of malnutrition and other nutritional deficiencies
0.004 0.864 0.132
E63 Other nutritional deficiencies
0.004 0.864 0.132
E56 Other vitamin deficiencies
0.004 0.864 0.132
E51 Thiamine deficiency
0.004 0.864 0.132
E50 Vitamin A deficiency
0.004 0.864 0.132
E60 Dietary zinc deficiency
0.004 0.864 0.132
E59 Dietary selenium deficiency
0.004 0.864 0.132
E58 Dietary calcium deficiency
0.004 0.864 0.132
E54 Ascorbic acid deficiency
0.004 0.864 0.132
E52 Niacin deficiency [pellagra]
0.004 0.864 0.132
E16.9 Disorder of pancreatic internal secretion, unspecified
0.002 0.865 0.133
E16.8 Other specified disorders of pancreatic internal secretion
0.002 0.865 0.133
E16.4 Abnormal secretion of gastrin
0.002 0.865 0.133
E16.3 Increased secretion of glucagon
0.002 0.865 0.133
E16.1 Other hypoglycaemia
0.002 0.865 0.133
E16.0 Drug-induced hypoglycaemia without coma
0.002 0.865 0.133
E22 Hyperfunction of pituitary gland
0.002 0.867 0.132
E55.9 Vitamin D deficiency, unspecified
0.001 0.870 0.128
C90 Multiple myeloma and malignant plasma cell neoplasms
0.122 0.877 0.001
C91.9 Lymphoid leukaemia, unspecified
0.120 0.879 0.000
E29.1 Testicular hypofunction
0.001 0.880 0.119
E27 Other disorders of adrenal gland
0.002 0.881 0.116
C92.9 Myeloid leukaemia, unspecified
0.117 0.882 0.000
C92.8 Acute myeloid leukaemia with multilineage dysplasia
0.117 0.882 0.000
C92.7 Other myeloid leukaemia
0.117 0.882 0.000
C92.6 Acute myeloid leukaemia with 11q23-abnormality
0.117 0.882 0.000
C92.5 Acute myelomonocytic leukaemia
0.117 0.882 0.000
C92.4 Acute promyelocytic leukaemia
0.117 0.882 0.000
C92.3 Myeloid sarcoma
0.117 0.882 0.000
C92.2 Subacute myeloid leukaemia
0.117 0.882 0.000
E53.9 Vitamin B deficiency, unspecified
0.002 0.883 0.115
E53.1 Pyridoxine deficiency
0.002 0.883 0.115
E53.0 Riboflavin deficiency
0.002 0.883 0.115
E23 Hypofunction and other disorders of pituitary gland
0.002 0.884 0.114
E35 Disorders of endocrine glands in diseases classified elsewhere
0.003 0.884 0.113
E34 Other endocrine disorders
0.003 0.884 0.113
E32 Diseases of thymus
0.003 0.884 0.113
E31 Polyglandular dysfunction
0.003 0.884 0.113
E30 Disorders of puberty, not elsewhere classified
0.003 0.884 0.113
E25 Adrenogenital disorders
0.003 0.884 0.113
E20 Hypoparathyroidism
0.003 0.884 0.113
K91.8 Other postprocedural disorders of digestive system, not elsewhere classified
0.000 0.885 0.115
E61 Deficiency of other nutrient elements
0.004 0.885 0.110
E24 Cushing's syndrome
0.003 0.886 0.111
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.001 0.887 0.112
E44 Protein-energy malnutrition of moderate and mild degree
0.005 0.887 0.107
E45 Retarded development following protein-energy malnutrition
0.005 0.887 0.107
E43 Unspecified severe protein-energy malnutrition
0.005 0.887 0.107
E42 Marasmic kwashiorkor
0.005 0.887 0.107
E41 Nutritional marasmus
0.005 0.887 0.107
E40 Kwashiorkor
0.005 0.887 0.107
C92.1 Chronic myeloid leukaemia
0.112 0.888 0.000
E55.0 Rickets, active
0.002 0.889 0.109
C91.8 Mature B-cell leukaemia Burkitt-type
0.109 0.890 0.000
C91.7 Other lymphoid leukaemia
0.109 0.890 0.000
C91.6 Prolymphocytic leukaemia of T-cell type
0.109 0.890 0.000
C91.5 Adult T-cell leukaemia
0.109 0.890 0.000
C91.3 Prolymphocytic leukaemia
0.109 0.890 0.000
C91.2 Subacute lymphocytic leukaemia
0.109 0.890 0.000
E46 Unspecified protein-energy malnutrition
0.005 0.891 0.104
C91.4 Hairy-cell leukaemia
0.108 0.891 0.000
E26 Hyperaldosteronism
0.003 0.894 0.103
K92.0 Haematemesis
0.000 0.894 0.106
E27.1 Primary adrenocortical insufficiency
0.001 0.897 0.102
C91.0 Acute lymphoblastic leukaemia
0.100 0.900 0.001
E29.9 Testicular dysfunction, unspecified
0.002 0.901 0.097
E29.8 Other testicular dysfunction
0.002 0.901 0.097
E29.0 Testicular hyperfunction
0.002 0.901 0.097
E22.1 Hyperprolactinaemia
0.001 0.902 0.097
E50.9 Vitamin A deficiency, unspecified
0.003 0.902 0.095
E50.8 Other manifestations of vitamin A deficiency
0.003 0.902 0.095
E50.7 Other ocular manifestations of vitamin A deficiency
0.003 0.902 0.095
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.003 0.902 0.095
E50.5 Vitamin A deficiency with night blindness
0.003 0.902 0.095
E50.4 Vitamin A deficiency with keratomalacia
0.003 0.902 0.095
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.003 0.902 0.095
E50.2 Vitamin A deficiency with corneal xerosis
0.003 0.902 0.095
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.003 0.902 0.095
E50.0 Vitamin A deficiency with conjunctival xerosis
0.003 0.902 0.095
E51.9 Thiamine deficiency, unspecified
0.003 0.902 0.095
E51.8 Other manifestations of thiamine deficiency
0.003 0.902 0.095
E51.2 Wernicke's encephalopathy
0.003 0.902 0.095
E51.1 Beriberi
0.003 0.902 0.095
E56.9 Vitamin deficiency, unspecified
0.003 0.902 0.095
E56.8 Deficiency of other vitamins
0.003 0.902 0.095
E56.1 Deficiency of vitamin K
0.003 0.902 0.095
E56.0 Deficiency of vitamin E
0.003 0.902 0.095
E63.9 Nutritional deficiency, unspecified
0.003 0.902 0.095
E63.8 Other specified nutritional deficiencies
0.003 0.902 0.095
E63.1 Imbalance of constituents of food intake
0.003 0.902 0.095
E63.0 Essential fatty acid [EFA] deficiency
0.003 0.902 0.095
E64.9 Sequelae of unspecified nutritional deficiency
0.003 0.902 0.095
E64.8 Sequelae of other nutritional deficiencies
0.003 0.902 0.095
E64.3 Sequelae of rickets
0.003 0.902 0.095
E64.2 Sequelae of vitamin C deficiency
0.003 0.902 0.095
E64.1 Sequelae of vitamin A deficiency
0.003 0.902 0.095
E64.0 Sequelae of protein-energy malnutrition
0.003 0.902 0.095
E22.0 Acromegaly and pituitary gigantism
0.001 0.904 0.095
E65-E68 Obesity and other hyperalimentation
0.007 0.904 0.089
E22.9 Hyperfunction of pituitary gland, unspecified
0.001 0.904 0.094
E22.8 Other hyperfunction of pituitary gland
0.001 0.904 0.094
E28 Ovarian dysfunction
0.003 0.907 0.090
C90.3 Solitary plasmacytoma
0.088 0.912 0.001
C90.1 Plasma cell leukaemia
0.088 0.912 0.001
E27.5 Adrenomedullary hyperfunction
0.002 0.915 0.084
E27.3 Drug-induced adrenocortical insufficiency
0.002 0.915 0.084
E27.2 Addisonian crisis
0.002 0.915 0.084
E27.0 Other adrenocortical overactivity
0.002 0.915 0.084
E23.2 Diabetes insipidus
0.002 0.915 0.083
E23.7 Disorder of pituitary gland, unspecified
0.002 0.916 0.082
E23.6 Other disorders of pituitary gland
0.002 0.916 0.082
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.002 0.916 0.082
E23.1 Drug-induced hypopituitarism
0.002 0.916 0.082
E20.9 Hypoparathyroidism, unspecified
0.002 0.917 0.081
E20.8 Other hypoparathyroidism
0.002 0.917 0.081
E20.1 Pseudohypoparathyroidism
0.002 0.917 0.081
E20.0 Idiopathic hypoparathyroidism
0.002 0.917 0.081
E25.9 Adrenogenital disorder, unspecified
0.002 0.917 0.081
E25.8 Other adrenogenital disorders
0.002 0.917 0.081
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.002 0.917 0.081
E30.9 Disorder of puberty, unspecified
0.002 0.917 0.081
E30.8 Other disorders of puberty
0.002 0.917 0.081
E30.1 Precocious puberty
0.002 0.917 0.081
E30.0 Delayed puberty
0.002 0.917 0.081
E31.9 Polyglandular dysfunction, unspecified
0.002 0.917 0.081
E31.8 Other polyglandular dysfunction
0.002 0.917 0.081
E31.1 Polyglandular hyperfunction
0.002 0.917 0.081
E31.0 Autoimmune polyglandular failure
0.002 0.917 0.081
E32.9 Disease of thymus, unspecified
0.002 0.917 0.081
E32.8 Other diseases of thymus
0.002 0.917 0.081
E32.1 Abscess of thymus
0.002 0.917 0.081
E32.0 Persistent hyperplasia of thymus
0.002 0.917 0.081
E34.9 Endocrine disorder, unspecified
0.002 0.917 0.081
E34.8 Other specified endocrine disorders
0.002 0.917 0.081
E34.5 Androgen resistance syndrome
0.002 0.917 0.081
E34.4 Constitutional tall stature
0.002 0.917 0.081
E34.3 Short stature, not elsewhere classified
0.002 0.917 0.081
E34.2 Ectopic hormone secretion, not elsewhere classified
0.002 0.917 0.081
E34.1 Other hypersecretion of intestinal hormones
0.002 0.917 0.081
E34.0 Carcinoid syndrome
0.002 0.917 0.081
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.002 0.917 0.081
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.002 0.917 0.081
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.002 0.917 0.081
E23.0 Hypopituitarism
0.001 0.917 0.082
E61.9 Deficiency of nutrient element, unspecified
0.003 0.918 0.079
E61.8 Deficiency of other specified nutrient elements
0.003 0.918 0.079
E61.7 Deficiency of multiple nutrient elements
0.003 0.918 0.079
E61.6 Vanadium deficiency
0.003 0.918 0.079
E61.5 Molybdenum deficiency
0.003 0.918 0.079
E61.4 Chromium deficiency
0.003 0.918 0.079
E61.3 Manganese deficiency
0.003 0.918 0.079
E61.2 Magnesium deficiency
0.003 0.918 0.079
E61.0 Copper deficiency
0.003 0.918 0.079
E24.8 Other Cushing's syndrome
0.002 0.918 0.080
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.002 0.918 0.080
E24.3 Ectopic ACTH syndrome
0.002 0.918 0.080
E24.2 Drug-induced Cushing's syndrome
0.002 0.918 0.080
E24.1 Nelson's syndrome
0.002 0.918 0.080
E24.0 Pituitary-dependent Cushing's disease
0.002 0.918 0.080
E27.4 Other and unspecified adrenocortical insufficiency
0.002 0.919 0.080
E44.1 Mild protein-energy malnutrition
0.004 0.919 0.077
E44.0 Moderate protein-energy malnutrition
0.004 0.919 0.077
E24.9 Cushing's syndrome, unspecified
0.002 0.920 0.078
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.003 0.922 0.075
E26.9 Hyperaldosteronism, unspecified
0.002 0.924 0.074
E26.8 Other hyperaldosteronism
0.002 0.924 0.074
E26.1 Secondary hyperaldosteronism
0.002 0.924 0.074
C90.2 Plasmacytoma, extramedullary
0.075 0.924 0.001
E27.8 Other specified disorders of adrenal gland
0.002 0.924 0.074
C92.0 Acute myeloid leukaemia
0.074 0.926 0.000
E27.9 Disorder of adrenal gland, unspecified
0.002 0.926 0.072
E67 Other hyperalimentation
0.005 0.931 0.064
E68 Sequelae of hyperalimentation
0.005 0.931 0.064
E28.9 Ovarian dysfunction, unspecified
0.002 0.933 0.065
E28.8 Other ovarian dysfunction
0.002 0.933 0.065
E28.1 Androgen excess
0.002 0.933 0.065
E28.0 Oestrogen excess
0.002 0.933 0.065
E26.0 Primary hyperaldosteronism
0.002 0.933 0.064
I21.9 Acute myocardial infarction, unspecified
0.067 0.933 0.000
E65 Localised adiposity
0.005 0.937 0.058
E28.3 Primary ovarian failure
0.002 0.938 0.060
E61.1 Iron deficiency
0.004 0.939 0.057
E21.5 Disorder of parathyroid gland, unspecified
0.002 0.944 0.054
E21.4 Other specified disorders of parathyroid gland
0.002 0.944 0.054
E21.2 Other hyperparathyroidism
0.002 0.944 0.054
E21.3 Hyperparathyroidism, unspecified
0.002 0.945 0.053
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.002 0.947 0.051
E28.2 Polycystic ovarian syndrome
0.003 0.948 0.050
E67.8 Other specified hyperalimentation
0.004 0.950 0.046
E67.3 Hypervitaminosis D
0.004 0.950 0.046
E67.2 Megavitamin-B6 syndrome
0.004 0.950 0.046
E67.1 Hypercarotenaemia
0.004 0.950 0.046
E67.0 Hypervitaminosis A
0.004 0.950 0.046
I21 Acute myocardial infarction
0.048 0.952 0.000
I21.0 Acute transmural myocardial infarction of anterior wall
0.048 0.952 0.000
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs
0.042 0.958 0.000
T42.4 Benzodiazepines
0.042 0.958 0.000
T36-T50 Poisoning by drugs, medicaments and biological substances
0.040 0.960 0.000
T43 Poisoning by psychotropic drugs, not elsewhere classified
0.038 0.962 0.000
C91.1 Chronic lymphocytic leukaemia
0.037 0.962 0.001
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances
0.037 0.962 0.000
T42.6 Other antiepileptic and sedative-hypnotic drugs
0.037 0.963 0.000
I21.1 Acute transmural myocardial infarction of inferior wall
0.036 0.964 0.000
T43.2 Other and unspecified antidepressants
0.036 0.964 0.000
T50.9 Other and unspecified drugs, medicaments and biological substances
0.036 0.964 0.000
I21.X Presumed acute myicardial infaction (unconfirmed)
0.035 0.965 0.000
E70-E90 Metabolic disorders
0.004 0.965 0.031
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified
0.033 0.967 0.000
I21.3 Acute transmural myocardial infarction of unspecified site
0.032 0.968 0.000
T42.1 Iminostilbenes
0.031 0.969 0.000
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.031 0.969 0.000
T43.0 Tricyclic and tetracyclic antidepressants
0.031 0.969 0.000
T46 Poisoning by agents primarily affecting the cardiovascular system
0.031 0.969 0.000
I21.2 Acute transmural myocardial infarction of other sites
0.031 0.969 0.000
T42.8 Anti-Parkinsonism drugs and other central muscle-tone depressants
0.030 0.970 0.000
T42.7 Antiepileptic and sedative-hypnotic drugs, unspecified
0.030 0.970 0.000
T42.5 Mixed antiepileptics, not elsewhere classified
0.030 0.970 0.000
T42.3 Barbiturates
0.030 0.970 0.000
T42.2 Succinimides and oxazolidinediones
0.030 0.970 0.000
T42.0 Hydantoin derivatives
0.030 0.970 0.000
T43.5 Other and unspecified antipsychotics and neuroleptics
0.030 0.970 0.000
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs
0.029 0.971 0.000
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system
0.029 0.971 0.000
T47 Poisoning by agents primarily affecting gastro-intestinal system
0.029 0.971 0.000
T41 Poisoning by anaesthetics and therapeutic gases
0.029 0.971 0.000
T37 Poisoning by other systemic anti-infectives and antiparasitics
0.029 0.971 0.000
T36 Poisoning by systemic antibiotics
0.029 0.971 0.000
E21.0 Primary hyperparathyroidism
0.003 0.971 0.026
E88 Other metabolic disorders
0.002 0.972 0.026
C90.0 Multiple myeloma
0.026 0.972 0.002
E83 Disorders of mineral metabolism
0.003 0.972 0.024
T45.0 Antiallergic and antiemetic drugs
0.028 0.972 0.000
T43.9 Psychotropic drug, unspecified
0.027 0.973 0.000
T43.8 Other psychotropic drugs, not elsewhere classified
0.027 0.973 0.000
T43.6 Psychostimulants with abuse potential
0.027 0.973 0.000
T43.4 Butyrophenone and thioxanthene neuroleptics
0.027 0.973 0.000
T43.1 Monoamine-oxidase-inhibitor antidepressants
0.027 0.973 0.000
T50.8 Diagnostic agents
0.027 0.973 0.000
T50.7 Analeptics and opioid receptor antagonists
0.027 0.973 0.000
T50.6 Antidotes and chelating agents, not elsewhere classified
0.027 0.973 0.000
T50.5 Appetite depressants
0.027 0.973 0.000
T50.4 Drugs affecting uric acid metabolism
0.027 0.973 0.000
T50.3 Electrolytic, caloric and water-balance agents
0.027 0.973 0.000
T50.2 Carbonic-anhydrase inhibitors, benzothiadiazides and other diuretics
0.027 0.973 0.000
T50.1 Loop [high-ceiling] diuretics
0.027 0.973 0.000
T50.0 Mineralocorticoids and their antagonists
0.027 0.973 0.000
T44 Poisoning by drugs primarily affecting the autonomic nervous system
0.027 0.973 0.000
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]
0.027 0.973 0.000
E83.1 Disorders of iron metabolism
0.000 0.973 0.026
E73 Lactose intolerance
0.002 0.973 0.024
J40-J47 Chronic lower respiratory diseases
0.002 0.973 0.025
J32.9 Chronic sinusitis, unspecified
0.026 0.974 0.000
E85 Amyloidosis
0.002 0.975 0.023
T46.6 Antihyperlipidaemic and antiarteriosclerotic drugs
0.025 0.975 0.000
T38.1 Thyroid hormones and substitutes
0.025 0.975 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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