TreeWAS – Variant ID: rs11757500

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
E03.9 Hypothyroidism, unspecified	0.000	0.000	1.000
J45.9 Asthma, unspecified	0.000	0.000	1.000
K90.0 Coeliac disease	0.000	0.005	0.995
M06.9 Rheumatoid arthritis, unspecified	0.000	0.027	0.973
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)	0.000	0.028	0.972
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)	0.000	0.033	0.967
J45 Asthma	0.000	0.055	0.945
Chapter XIII Diseases of the musculoskeletal system and connective tissue	0.914	0.072	0.015
J40-J47 Chronic lower respiratory diseases	0.000	0.088	0.912
J44 Other chronic obstructive pulmonary disease	0.000	0.088	0.912
M70-M79 Other soft tissue disorders	0.909	0.089	0.002
M79 Other soft tissue disorders, not elsewhere classified	0.898	0.102	0.000
M50-M54 Other dorsopathies	0.894	0.104	0.002
J44.0 Chronic obstructive pulmonary disease with acute lower respiratory infection	0.000	0.107	0.893
M79.6 Pain in limb	0.883	0.117	0.000
M54 Dorsalgia	0.878	0.122	0.000
M79.66 Pain in limb (Lower leg)	0.865	0.135	0.000
M05-M14 Inflammatory polyarthropathies	0.708	0.138	0.154
J44.9 Chronic obstructive pulmonary disease, unspecified	0.000	0.143	0.857
M06.96 Rheumatoid arthritis, unspecified (Lower leg)	0.000	0.146	0.854
M06 Other rheumatoid arthritis	0.117	0.149	0.734
M54.9 Dorsalgia, unspecified	0.849	0.151	0.000
J44.8 Other specified chronic obstructive pulmonary disease	0.000	0.153	0.847
M06.94 Rheumatoid arthritis, unspecified (Hand)	0.000	0.159	0.841
E03 Other hypothyroidism	0.000	0.168	0.832
M79.67 Pain in limb (Ankle and foot)	0.831	0.169	0.000
M45-M49 Spondylopathies	0.812	0.183	0.006
J46 Status asthmaticus	0.000	0.188	0.812
M15-M19 Arthrosis	0.804	0.195	0.001
M75 Shoulder lesions	0.802	0.198	0.000
M65-M68 Disorders of synovium and tendon	0.795	0.200	0.005
M79.7 Fibromyalgia	0.795	0.204	0.000
M75.1 Rotator cuff syndrome	0.787	0.213	0.000
M80-M85 Disorders of bone density and structure	0.773	0.213	0.014
M54.99 Dorsalgia, unspecified (Site unspecified)	0.785	0.215	0.000
M86-M90 Other osteopathies	0.775	0.216	0.008
M13 Other arthritis	0.693	0.228	0.079
M54.1 Radiculopathy	0.767	0.233	0.000
M17 Gonarthrosis [arthrosis of knee]	0.757	0.243	0.000
M17.1 Other primary gonarthrosis	0.752	0.248	0.000
M47 Spondylosis	0.748	0.250	0.002
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)	0.000	0.253	0.747
M54.3 Sciatica	0.732	0.267	0.000
M47.8 Other spondylosis	0.731	0.268	0.000
M54.94 Dorsalgia, unspecified (Thoracic region)	0.731	0.269	0.000
M70 Soft tissue disorders related to use, overuse and pressure	0.728	0.271	0.001
E00-E07 Disorders of thyroid gland	0.000	0.273	0.727
M51 Other intervertebral disk disorders	0.724	0.275	0.001
M79.79 Fibromyalgia (Site unspecified)	0.720	0.280	0.000
M20-M25 Other joint disorders	0.717	0.282	0.001
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)	0.000	0.282	0.717
M47.86 Other spondylosis (Lumbar region)	0.711	0.289	0.000
M06.0 Seronegative rheumatoid arthritis	0.056	0.295	0.649
M54.4 Lumbago with sciatica	0.702	0.298	0.000
M79.5 Residual foreign body in soft tissue	0.701	0.299	0.000
M60-M63 Disorders of muscles	0.690	0.300	0.010
M06.98 Rheumatoid arthritis, unspecified (Other)	0.000	0.302	0.697
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)	0.000	0.302	0.697
M06.92 Rheumatoid arthritis, unspecified (Upper arm)	0.000	0.302	0.697
M79.2 Neuralgia and neuritis, unspecified	0.697	0.303	0.000
M00-M03 Infectious arthropathies	0.687	0.303	0.010
M46 Other inflammatory spondylopathies	0.688	0.309	0.003
M13.9 Arthritis, unspecified	0.687	0.309	0.004
M84 Disorders of continuity of bone	0.675	0.318	0.007
E05 Thyrotoxicosis [hyperthyroidism]	0.000	0.318	0.682
M54.36 Sciatica (Lumbar region)	0.678	0.322	0.000
J45.8 Mixed asthma	0.000	0.323	0.677
J45.1 Nonallergic asthma	0.000	0.323	0.677
M95-M99 Other disorders of the musculoskeletal system and connective tissue	0.667	0.323	0.009
M72 Fibroblastic disorders	0.675	0.324	0.001
M13.99 Arthritis, unspecified (Site unspecified)	0.675	0.325	0.000
M79.62 Pain in limb (Upper arm)	0.674	0.326	0.000
M89 Other disorders of bone	0.667	0.328	0.005
M54.97 Dorsalgia, unspecified (Lumbosacral region)	0.670	0.330	0.000
M67 Other disorders of synovium and tendon	0.666	0.331	0.003
M06.93 Rheumatoid arthritis, unspecified (Forearm)	0.000	0.331	0.669
M75.2 Bicipital tendinitis	0.667	0.333	0.000
M13.90 Arthritis, unspecified (Multiple sites)	0.658	0.341	0.001
J41 Simple and mucopurulent chronic bronchitis	0.000	0.346	0.654
M76 Enthesopathies of lower limb, excluding foot	0.652	0.347	0.001
M73 Soft tissue disorders in diseases classified elsewhere	0.652	0.347	0.001
M54.90 Dorsalgia, unspecified (Multiple sites in spine)	0.652	0.348	0.000
E05.9 Thyrotoxicosis, unspecified	0.000	0.349	0.651
M79.64 Pain in limb (Hand)	0.649	0.351	0.000
M77 Other enthesopathies	0.645	0.354	0.001
M65 Synovitis and tenosynovitis	0.644	0.354	0.002
M24 Other specific joint derangements	0.645	0.355	0.000
M25 Other joint disorders, not elsewhere classified	0.645	0.355	0.000
M79.9 Soft tissue disorder, unspecified	0.643	0.356	0.000
M79.4 Hypertrophy of (infrapatellar) fat pad	0.643	0.356	0.000
M79.3 Panniculitis, unspecified	0.643	0.356	0.000
M15 Polyarthrosis	0.638	0.362	0.000
M79.68 Pain in limb (Other)	0.633	0.367	0.000
M51.2 Other specified intervertebral disk displacement	0.631	0.368	0.000
M54.8 Other dorsalgia	0.629	0.371	0.000
M54.0 Panniculitis affecting regions of neck and back	0.629	0.371	0.000
M40-M43 Deforming dorsopathies	0.618	0.373	0.009
M79.61 Pain in limb (Shoulder region)	0.627	0.373	0.000
J45.0 Predominantly allergic asthma	0.000	0.373	0.627
M91-M94 Chondropathies	0.616	0.373	0.011
M53 Other dorsopathies, not elsewhere classified	0.624	0.374	0.002
M18 Arthrosis of first carpometacarpal joint	0.623	0.377	0.000
M79.1 Myalgia	0.619	0.381	0.000
M14 Arthropathies in other diseases classified elsewhere	0.508	0.382	0.111
M12 Other specific arthropathies	0.508	0.382	0.111
M09 Juvenile arthritis in diseases classified elsewhere	0.508	0.382	0.111
M08 Juvenile arthritis	0.508	0.382	0.111
M79.0 Rheumatism, unspecified	0.618	0.382	0.000
M71 Other bursopathies	0.614	0.384	0.001
E06 Thyroiditis	0.000	0.386	0.614
M06.8 Other specified rheumatoid arthritis	0.084	0.390	0.526
M06.4 Inflammatory polyarthropathy	0.084	0.390	0.526
M06.3 Rheumatoid nodule	0.084	0.390	0.526
M06.2 Rheumatoid bursitis	0.084	0.390	0.526
M06.1 Adult-onset Still's disease	0.084	0.390	0.526
M54.98 Dorsalgia, unspecified (Sacral and sacrococcygeal region)	0.609	0.391	0.000
M54.95 Dorsalgia, unspecified (Thoracolumbar region)	0.609	0.391	0.000
M54.93 Dorsalgia, unspecified (Cervicothoracic region)	0.609	0.391	0.000
M54.92 Dorsalgia, unspecified (Cervical region)	0.609	0.391	0.000
M54.91 Dorsalgia, unspecified (Occipito-atlanto-axial region)	0.609	0.391	0.000
M23 Internal derangement of knee	0.608	0.392	0.000
M54.18 Radiculopathy (Sacral and sacrococcygeal region)	0.607	0.393	0.000
M54.17 Radiculopathy (Lumbosacral region)	0.605	0.395	0.000
M46.9 Inflammatory spondylopathy, unspecified	0.600	0.399	0.001
M47.89 Other spondylosis (Site unspecified)	0.601	0.399	0.000
M06.00 Seronegative rheumatoid arthritis (Multiple sites)	0.024	0.399	0.577
M82 Osteoporosis in diseases classified elsewhere	0.591	0.400	0.010
M79.69 Pain in limb (Site unspecified)	0.599	0.401	0.000
M70.2 Olecranon bursitis	0.597	0.403	0.001
E03.5 Myxoedema coma	0.000	0.404	0.596
E03.4 Atrophy of thyroid (acquired)	0.000	0.404	0.596
E03.3 Postinfectious hypothyroidism	0.000	0.404	0.596
E03.2 Hypothyroidism due to medicaments and other exogenous substances	0.000	0.404	0.596
E03.1 Congenital hypothyroidism without goitre	0.000	0.404	0.596
E03.0 Congenital hypothyroidism with diffuse goitre	0.000	0.404	0.596
M85 Other disorders of bone density and structure	0.587	0.404	0.009
M54.96 Dorsalgia, unspecified (Lumbar region)	0.593	0.407	0.000
M54.12 Radiculopathy (Cervical region)	0.593	0.407	0.000
M25.6 Stiffness of joint, not elsewhere classified	0.590	0.410	0.000
M11 Other crystal arthropathies	0.478	0.411	0.111
M87 Osteonecrosis	0.582	0.413	0.005
M49 Spondylopathies in diseases classified elsewhere	0.582	0.414	0.004
M80 Osteoporosis with pathological fracture	0.574	0.417	0.009
M50 Cervical disk disorders	0.581	0.418	0.001
M72.2 Plantar fascial fibromatosis	0.580	0.419	0.001
M79.65 Pain in limb (Pelvic region and thigh)	0.580	0.420	0.000
M79.70 Fibromyalgia (Multiple sites)	0.578	0.422	0.000
M89.8 Other specified disorders of bone	0.575	0.422	0.003
M84.1 Nonunion of fracture [pseudarthrosis]	0.573	0.424	0.003
M66 Spontaneous rupture of synovium and tendon	0.572	0.424	0.004
M54.6 Pain in thoracic spine	0.575	0.425	0.000
M75.8 Other shoulder lesions	0.575	0.425	0.000
M75.9 Shoulder lesion, unspecified	0.575	0.425	0.000
M68 Disorders of synovium and tendon in diseases classified elsewhere	0.570	0.426	0.004
M54.16 Radiculopathy (Lumbar region)	0.572	0.428	0.000
M79.78 Fibromyalgia (Other)	0.570	0.430	0.000
M79.77 Fibromyalgia (Ankle and foot)	0.570	0.430	0.000
M79.76 Fibromyalgia (Lower leg)	0.570	0.430	0.000
M79.75 Fibromyalgia (Pelvic region and thigh)	0.570	0.430	0.000
M79.74 Fibromyalgia (Hand)	0.570	0.430	0.000
M79.73 Fibromyalgia (Forearm)	0.570	0.430	0.000
M79.72 Fibromyalgia (Upper arm)	0.570	0.430	0.000
M79.71 Fibromyalgia (Shoulder region)	0.570	0.430	0.000
M88 Paget's disease of bone [osteitis deformans]	0.565	0.430	0.006
M54.19 Radiculopathy (Site unspecified)	0.569	0.431	0.000
M54.46 Lumbago with sciatica (Lumbar region)	0.565	0.435	0.000
M83 Adult osteomalacia	0.554	0.435	0.010
M47.82 Other spondylosis (Cervical region)	0.564	0.436	0.000
M25.7 Osteophyte	0.561	0.439	0.000
M07 Psoriatic and enteropathic arthropathies	0.442	0.439	0.119
E03.8 Other specified hypothyroidism	0.000	0.439	0.561
M79.54 Residual foreign body in soft tissue (Hand)	0.560	0.440	0.000
M54.37 Sciatica (Lumbosacral region)	0.559	0.441	0.000
M89.0 Algoneurodystrophy	0.554	0.443	0.003
M86 Osteomyelitis	0.550	0.444	0.006
M47.1 Other spondylosis with myelopathy	0.554	0.445	0.001
M05 Seropositive rheumatoid arthritis	0.429	0.445	0.125
M13.8 Other specified arthritis	0.497	0.446	0.057
M13.1 Monoarthritis, not elsewhere classified	0.497	0.446	0.057
M32 Systemic lupus erythematosus	0.553	0.447	0.001
M13.97 Arthritis, unspecified (Ankle and foot)	0.550	0.448	0.002
M67.8 Other specified disorders of synovium and tendon	0.551	0.448	0.001
M90 Osteopathies in diseases classified elsewhere	0.545	0.449	0.006
M21 Other acquired deformities of limbs	0.550	0.449	0.001
M54.15 Radiculopathy (Thoracolumbar region)	0.550	0.450	0.000
M54.14 Radiculopathy (Thoracic region)	0.550	0.450	0.000
M54.13 Radiculopathy (Cervicothoracic region)	0.550	0.450	0.000
M54.11 Radiculopathy (Occipito-atlanto-axial region)	0.550	0.450	0.000
M54.10 Radiculopathy (Multiple sites in spine)	0.550	0.450	0.000
M54.5 Low back pain	0.549	0.451	0.000
M24.2 Disorder of ligament	0.548	0.451	0.000
M84.0 Malunion of fracture	0.544	0.452	0.004
M70.4 Prepatellar bursitis	0.546	0.453	0.001
M18.0 Primary arthrosis of first carpometacarpal joints, bilateral	0.545	0.455	0.000
M17.5 Other secondary gonarthrosis	0.543	0.457	0.000
M17.4 Other secondary gonarthrosis, bilateral	0.543	0.457	0.000
M17.2 Posttraumatic gonarthrosis, bilateral	0.543	0.457	0.000
M75.4 Impingement syndrome of shoulder	0.541	0.459	0.000
M47.87 Other spondylosis (Lumbosacral region)	0.541	0.459	0.000
M47.0 Anterior spinal and vertebral artery compression syndromes	0.536	0.462	0.002
M62 Other disorders of muscle	0.530	0.463	0.007
M13.93 Arthritis, unspecified (Forearm)	0.534	0.463	0.003
M54.2 Cervicalgia	0.534	0.465	0.000
M25.77 Osteophyte (Ankle and foot)	0.534	0.466	0.000
E06.3 Autoimmune thyroiditis	0.000	0.467	0.532
E05.0 Thyrotoxicosis with diffuse goitre	0.000	0.469	0.531
M00 Pyogenic arthritis	0.524	0.469	0.007
M79.28 Neuralgia and neuritis, unspecified (Other)	0.530	0.469	0.000
J44.1 Chronic obstructive pulmonary disease with acute exacerbation, unspecified	0.000	0.470	0.529
M06.09 Seronegative rheumatoid arthritis (Site unspecified)	0.035	0.471	0.495
M79.29 Neuralgia and neuritis, unspecified (Site unspecified)	0.527	0.473	0.000
M54.38 Sciatica (Sacral and sacrococcygeal region)	0.525	0.475	0.000
M54.35 Sciatica (Thoracolumbar region)	0.525	0.475	0.000
M54.34 Sciatica-Thoracic	0.525	0.475	0.000
M54.33 Sciatica-Cervicothoracic	0.525	0.475	0.000
M54.32 Sciatica-Cervical	0.525	0.475	0.000
M54.31 Sciatica-Occipit-atl-axl	0.525	0.475	0.000
M54.30 Sciatica (Multiple sites in spine)	0.525	0.475	0.000
M47.88 Other spondylosis (Sacral and sacrococcygeal region)	0.524	0.475	0.000
M47.85 Other spondylosis (Thoracolumbar region)	0.524	0.475	0.000
M47.84 Other spondylosis (Thoracic region)	0.524	0.475	0.000
M47.83 Other spondylosis (Cervicothoracic region)	0.524	0.475	0.000
M47.81 Other spondylosis (Occipito-atlanto-axial region)	0.524	0.475	0.000
M70.9 Unspecified soft tissue disorder related to use, overuse and pressure	0.522	0.477	0.001
M70.8 Other soft tissue disorders related to use, overuse and pressure	0.522	0.477	0.001
M70.7 Other bursitis of hip	0.522	0.477	0.001
M70.5 Other bursitis of knee	0.522	0.477	0.001
M70.3 Other bursitis of elbow	0.522	0.477	0.001
M70.1 Bursitis of hand	0.522	0.477	0.001
M70.0 Chronic crepitant synovitis of hand and wrist	0.522	0.477	0.001
M45 Ankylosing spondylitis	0.519	0.477	0.004
E01 Iodine-deficiency-related thyroid disorders and allied conditions	0.000	0.479	0.521
E00 Congenital iodine-deficiency syndrome	0.000	0.479	0.521
E02 Subclinical iodine-deficiency hypothyroidism	0.000	0.479	0.521
M51.0 Lumbar and other intervertebral disk disorders with myelopathy	0.521	0.479	0.001
M25.66 Stiffness of joint, not elsewhere classified (Lower leg)	0.521	0.479	0.000
M51.3 Other specified intervertebral disk degeneration	0.519	0.480	0.001
M51.1 Lumbar and other intervertebral disk disorders with radiculopathy	0.519	0.480	0.001
M51.4 Schmorl's nodes	0.519	0.480	0.001
M79.63 Pain in limb (Forearm)	0.519	0.481	0.000
M15.1 Heberden's nodes (with arthropathy)	0.518	0.482	0.000
M54.49 Lumbago with sciatica (Site unspecified)	0.518	0.482	0.000
E07 Other disorders of thyroid	0.000	0.482	0.518
M67.1 Other contracture of tendon (sheath)	0.516	0.483	0.002
M95 Other acquired deformities of musculoskeletal system and connective tissue	0.511	0.483	0.006
M36 Systemic disorders of connective tissue in diseases classified elsewhere	0.514	0.485	0.001
M33 Dermatopolymyositis	0.514	0.485	0.001
M30 Polyarteritis nodosa and related conditions	0.514	0.485	0.001
M72.27 Plantar fascial fibromatosis-Ankle/Foot	0.513	0.487	0.000
M24.8 Other specific joint derangements, not elsewhere classified	0.511	0.489	0.000
M89.87 Other specified disorders of bone (Ankle and foot)	0.509	0.489	0.001
M84.11 Nonunion of fracture [pseudarthrosis] (Shoulder region)	0.507	0.492	0.001
M65.9 Synovitis and tenosynovitis, unspecified	0.506	0.493	0.001
M06.08 Seronegative rheumatoid arthritis (Other)	0.041	0.494	0.465
M06.07 Seronegative rheumatoid arthritis (Ankle and foot)	0.041	0.494	0.465
M06.06 Seronegative rheumatoid arthritis (Lower leg)	0.041	0.494	0.465
M06.05 Seronegative rheumatoid arthritis (Pelvic region and thigh)	0.041	0.494	0.465
M06.04 Seronegative rheumatoid arthritis (Hand)	0.041	0.494	0.465
M06.03 Seronegative rheumatoid arthritis (Forearm)	0.041	0.494	0.465
M06.02 Seronegative rheumatoid arthritis (Upper arm)	0.041	0.494	0.465
M06.01 Seronegative rheumatoid arthritis (Shoulder region)	0.041	0.494	0.465
M51.8 Other specified intervertebral disk disorders	0.505	0.495	0.001
M77.9 Enthesopathy, unspecified	0.503	0.496	0.001
M23.8 Other internal derangements of knee	0.504	0.496	0.000
M10 Gout	0.401	0.496	0.103
M54.48 Lumbago with sciatica (Sacral and sacrococcygeal region)	0.503	0.497	0.000
M54.47 Lumbago with sciatica (Lumbosacral region)	0.503	0.497	0.000
M54.45 Lumbago with sciatica (Thoracolumbar region)	0.503	0.497	0.000
M54.44 Lumbago with sciatica-Thoracic	0.503	0.497	0.000
M54.43 Lumbago with sciatica-Cervicothoracic	0.503	0.497	0.000
M54.42 Lumbago with sciatica-Cervical	0.503	0.497	0.000
M54.41 Lumbago with sciatica-Occipit-atl-axl	0.503	0.497	0.000
M54.40 Lumbago with sciatica (Multiple sites in spine)	0.503	0.497	0.000
M79.59 Residual foreign body in soft tissue (Site unspecified)	0.502	0.497	0.000
M79.58 Residual foreign body in soft tissue (Other)	0.502	0.497	0.000
M79.57 Residual foreign body in soft tissue (Ankle and foot)	0.502	0.497	0.000
M79.56 Residual foreign body in soft tissue (Lower leg)	0.502	0.497	0.000
M79.55 Residual foreign body in soft tissue (Pelvic region and thigh)	0.502	0.497	0.000
M79.53 Residual foreign body in soft tissue (Forearm)	0.502	0.497	0.000
M79.52 Residual foreign body in soft tissue (Upper arm)	0.502	0.497	0.000
M79.51 Residual foreign body in soft tissue (Shoulder region)	0.502	0.497	0.000
M79.50 Residual foreign body in soft tissue (Multiple sites)	0.502	0.497	0.000
M46.92 Inflammatory spondylopathy, unspecified (Cervical region)	0.502	0.497	0.001
M70.22 Olecranon bursitis-Upper arm	0.502	0.497	0.000
M63 Disorders of muscle in diseases classified elsewhere	0.495	0.498	0.007
M61 Calcification and ossification of muscle	0.495	0.498	0.007
M60 Myositis	0.495	0.498	0.007
M24.5 Contracture of joint	0.501	0.499	0.000
M25.9 Joint disorder, unspecified	0.501	0.499	0.000
M70.6 Trochanteric bursitis	0.499	0.500	0.001
M79.27 Neuralgia and neuritis, unspecified (Ankle and foot)	0.500	0.500	0.000
M79.26 Neuralgia and neuritis, unspecified (Lower leg)	0.500	0.500	0.000
M79.25 Neuralgia and neuritis, unspecified (Pelvic region and thigh)	0.500	0.500	0.000
M79.24 Neuralgia and neuritis, unspecified (Hand)	0.500	0.500	0.000
M79.23 Neuralgia and neuritis, unspecified (Forearm)	0.500	0.500	0.000
M79.22 Neuralgia and neuritis, unspecified (Upper arm)	0.500	0.500	0.000
M79.21 Neuralgia and neuritis, unspecified (Shoulder region)	0.500	0.500	0.000
M79.20 Neuralgia and neuritis, unspecified (Multiple sites)	0.500	0.500	0.000
M03 Postinfective and reactive arthropathies in diseases classified elsewhere	0.492	0.500	0.007
M02 Reactive arthropathies	0.492	0.500	0.007
M01 Direct infections of joint in infectious and parasitic diseases classified elsewhere	0.492	0.500	0.007
M17.0 Primary gonarthrosis, bilateral	0.498	0.502	0.000
M46.8 Other specified inflammatory spondylopathies	0.494	0.504	0.002
M46.5 Other infective spondylopathies	0.494	0.504	0.002
M46.4 Discitis, unspecified	0.494	0.504	0.002
M46.3 Infection of intervertebral disk (pyogenic)	0.494	0.504	0.002
M46.2 Osteomyelitis of vertebra	0.494	0.504	0.002
M46.1 Sacro-iliitis, not elsewhere classified	0.494	0.504	0.002
M46.0 Spinal enthesopathy	0.494	0.504	0.002
M13.92 Arthritis, unspecified (Upper arm)	0.492	0.504	0.003
M65.3 Trigger finger	0.491	0.508	0.001
M54.56 Low back pain (Lumbar region)	0.492	0.508	0.000
M18.1 Other primary arthrosis of first carpometacarpal joint	0.489	0.511	0.000
M24.0 Loose body in joint	0.489	0.511	0.000
M84.9 Disorder of continuity of bone, unspecified	0.484	0.511	0.005
M84.8 Other disorders of continuity of bone	0.484	0.511	0.005
M84.4 Pathological fracture, not elsewhere classified	0.484	0.511	0.005
M84.3 Stress fracture, not elsewhere classified	0.484	0.511	0.005
M84.2 Delayed union of fracture	0.484	0.511	0.005
E05.8 Other thyrotoxicosis	0.000	0.511	0.489
E05.5 Thyroid crisis or storm	0.000	0.511	0.489
E05.4 Thyrotoxicosis factitia	0.000	0.511	0.489
E05.3 Thyrotoxicosis from ectopic thyroid tissue	0.000	0.511	0.489
E05.1 Thyrotoxicosis with toxic single thyroid nodule	0.000	0.511	0.489
M13.0 Polyarthritis, unspecified	0.426	0.511	0.063
J43 Emphysema	0.000	0.514	0.486
M99 Biomechanical lesions, not elsewhere classified	0.478	0.515	0.007
M72.9 Fibroblastic disorder, unspecified	0.484	0.515	0.001
M72.8 Other fibroblastic disorders	0.484	0.515	0.001
M72.6 Necrotizing fasciitis	0.484	0.515	0.001
M72.5 Fasciitis, not elsewhere classified	0.484	0.515	0.001
M72.4 Pseudosarcomatous fibromatosis	0.484	0.515	0.001
M72.3 Nodular fasciitis	0.484	0.515	0.001
M72.1 Knuckle pads	0.484	0.515	0.001
M89.6 Osteopathy after poliomyelitis	0.478	0.518	0.004
M89.5 Osteolysis	0.478	0.518	0.004
M89.4 Other hypertrophic osteo-arthropathy	0.478	0.518	0.004
M89.3 Hypertrophy of bone	0.478	0.518	0.004
M89.2 Other disorders of bone development and growth	0.478	0.518	0.004
M89.1 Epiphyseal arrest	0.478	0.518	0.004
M77.1 Lateral epicondylitis	0.480	0.519	0.001
M67.9 Disorder of synovium and tendon, unspecified	0.478	0.520	0.002
M67.4 Ganglion	0.478	0.520	0.002
M67.3 Transient synovitis	0.478	0.520	0.002
M67.2 Synovial hypertrophy, not elsewhere classified	0.478	0.520	0.002
M67.0 Short Achilles tendon (acquired)	0.478	0.520	0.002
J42 Unspecified chronic bronchitis	0.000	0.523	0.477
M23.4 Loose body in knee	0.476	0.523	0.000
M65.4 Radial styloid tenosynovitis [de Quervain]	0.475	0.524	0.001
M47.80 Other spondylosis (Multiple sites in spine)	0.476	0.524	0.000
M23.0 Cystic meniscus	0.475	0.525	0.000
M89.04 Algoneurodystrophy (Hand)	0.473	0.526	0.002
K90 Intestinal malabsorption	0.000	0.527	0.473
M40 Kyphosis and lordosis	0.467	0.527	0.006
M13.98 Arthritis, unspecified (Other)	0.469	0.528	0.003
M47.2 Other spondylosis with radiculopathy	0.469	0.529	0.002
M51.9 Intervertebral disk disorder, unspecified	0.470	0.529	0.001
M46.90 Inflammatory spondylopathy, unspecified (Multiple sites in spine)	0.468	0.531	0.001
J41.8 Mixed simple and mucopurulent chronic bronchitis	0.000	0.531	0.469
J41.1 Mucopurulent chronic bronchitis	0.000	0.531	0.469
J41.0 Simple chronic bronchitis	0.000	0.531	0.469
M73.8 Other soft tissue disorders in diseases classified elsewhere	0.467	0.531	0.001
M73.1 Syphilitic bursitis	0.467	0.531	0.001
M73.0 Gonococcal bursitis	0.467	0.531	0.001
M76.9 Enthesopathy of lower limb, unspecified	0.467	0.531	0.001
M76.8 Other enthesopathies of lower limb, excluding foot	0.467	0.531	0.001
M76.7 Peroneal tendinitis	0.467	0.531	0.001
M76.6 Achilles tendinitis	0.467	0.531	0.001
M76.5 Patellar tendinitis	0.467	0.531	0.001
M76.4 Tibial collateral bursitis [Pellegrini-Stieda]	0.467	0.531	0.001
M76.3 Iliotibial band syndrome	0.467	0.531	0.001
M76.2 Iliac crest spur	0.467	0.531	0.001
M76.1 Psoas tendinitis	0.467	0.531	0.001
M76.0 Gluteal tendinitis	0.467	0.531	0.001
M17.3 Other posttraumatic gonarthrosis	0.468	0.532	0.000
M34 Systemic sclerosis	0.467	0.532	0.001
M82.1 Osteoporosis in endocrine disorders	0.460	0.534	0.006
M50.0 Cervical disk disorder with myelopathy	0.465	0.534	0.001
M80.0 Postmenopausal osteoporosis with pathological fracture	0.458	0.536	0.005
M25.67 Stiffness of joint, not elsewhere classified (Ankle and foot)	0.464	0.536	0.000
M77.8 Other enthesopathies, not elsewhere classified	0.463	0.536	0.001
M77.5 Other enthesopathy of foot	0.463	0.536	0.001
M77.3 Calcaneal spur	0.463	0.536	0.001
M77.2 Periarthritis of wrist	0.463	0.536	0.001
M77.0 Medial epicondylitis	0.463	0.536	0.001
M65.8 Other synovitis and tenosynovitis	0.462	0.536	0.002
M65.2 Calcific tendinitis	0.462	0.536	0.002
M65.1 Other infective (teno)synovitis	0.462	0.536	0.002
M65.0 Abscess of tendon sheath	0.462	0.536	0.002
M24.9 Joint derangement, unspecified	0.462	0.537	0.000
M24.7 Protrusio acetabuli	0.462	0.537	0.000
M24.6 Ankylosis of joint	0.462	0.537	0.000
M24.3 Pathological dislocation and subluxation of joint, not elsewhere classified	0.462	0.537	0.000
M25.2 Flail joint	0.462	0.537	0.000
M25.1 Fistula of joint	0.462	0.537	0.000
M79.39 Panniculitis, unspecified (Site unspecified)	0.461	0.538	0.000
M79.38 Panniculitis, unspecified (Other)	0.461	0.538	0.000
M79.37 Panniculitis, unspecified (Ankle and foot)	0.461	0.538	0.000
M79.36 Panniculitis, unspecified (Lower leg)	0.461	0.538	0.000
M79.35 Panniculitis, unspecified (Pelvic region and thigh)	0.461	0.538	0.000
M79.34 Panniculitis, unspecified (Hand)	0.461	0.538	0.000
M79.33 Panniculitis, unspecified (Forearm)	0.461	0.538	0.000
M79.32 Panniculitis, unspecified (Upper arm)	0.461	0.538	0.000
M79.31 Panniculitis, unspecified (Shoulder region)	0.461	0.538	0.000
M79.30 Panniculitis, unspecified (Multiple sites)	0.461	0.538	0.000
M79.49 Hypertrophy of (infrapatellar) fat pad-Site unspec	0.461	0.538	0.000
M79.48 Hypertrophy of (infrapatellar) fat pad (Other)	0.461	0.538	0.000
M79.47 Hypertrophy of (infrapatellar) fat pad (Ankle and foot)	0.461	0.538	0.000
M79.46 Hypertrophy of (infrapatellar) fat pad (Lower leg)	0.461	0.538	0.000
M79.45 Hypertrophy of (infrapatellar) fat pad (Pelvic region and thigh)	0.461	0.538	0.000
M79.44 Hypertrophy of (infrapatellar) fat pad (Hand)	0.461	0.538	0.000
M79.43 Hypertrophy of (infrapatellar) fat pad (Forearm)	0.461	0.538	0.000
M79.42 Hypertrophy of (infrapatellar) fat pad (Upper arm)	0.461	0.538	0.000
M79.41 Hypertrophy of (infrapatellar) fat pad (Shoulder region)	0.461	0.538	0.000
M79.40 Hypertrophy of (infrapatellar) fat pad (Multiple sites)	0.461	0.538	0.000
M79.99 Soft tissue disorder, unspecified (Site unspecified)	0.461	0.538	0.000
M79.98 Soft tissue disorder, unspecified (Other)	0.461	0.538	0.000
M79.97 Soft tissue disorder, unspecified (Ankle and foot)	0.461	0.538	0.000
M79.96 Soft tissue disorder, unspecified (Lower leg)	0.461	0.538	0.000
M79.95 Soft tissue disorder, unspecified (Pelvic region and thigh)	0.461	0.538	0.000
M79.94 Soft tissue disorder, unspecified (Hand)	0.461	0.538	0.000
M79.93 Soft tissue disorder, unspecified (Forearm)	0.461	0.538	0.000
M79.92 Soft tissue disorder, unspecified (Upper arm)	0.461	0.538	0.000
M79.91 Soft tissue disorder, unspecified (Shoulder region)	0.461	0.538	0.000
M79.90 Soft tissue disorder, unspecified (Multiple sites)	0.461	0.538	0.000
M50.1 Cervical disk disorder with radiculopathy	0.460	0.540	0.001
M96 Postprocedural musculoskeletal disorders, not elsewhere classified	0.453	0.540	0.007
M46.97 Inflammatory spondylopathy, unspecified (Lumbosacral region)	0.459	0.540	0.001
M25.0 Haemarthrosis	0.458	0.541	0.000
M15.9 Polyarthrosis, unspecified	0.457	0.542	0.000
M15.0 Primary generalised (osteo)arthrosis	0.457	0.542	0.000
M15.8 Other polyarthrosis	0.457	0.542	0.000
M15.4 Erosive (osteo)arthrosis	0.457	0.542	0.000
M15.3 Secondary multiple arthrosis	0.457	0.542	0.000
M15.2 Bouchard's nodes (with arthropathy)	0.457	0.542	0.000
M65.97 Synovitis and tenosynovitis, unspecified (Ankle and foot)	0.457	0.543	0.000
M24.1 Other articular cartilage disorders	0.456	0.543	0.000
M25.4 Effusion of joint	0.456	0.544	0.000
M85.0 Fibrous dysplasia (monostotic)	0.450	0.544	0.006
M24.26 Disorder of ligament (Lower leg)	0.455	0.545	0.000
M19 Other arthrosis	0.455	0.545	0.000
M13.95 Arthritis, unspecified (Pelvic region and thigh)	0.451	0.546	0.003
M25.8 Other specified joint disorders	0.453	0.547	0.000
M84.04 Malunion of fracture (Hand)	0.450	0.548	0.002
M25.3 Other instability of joint	0.452	0.548	0.000
M79.00 Rheumatism, unspecified (Multiple sites)	0.451	0.548	0.000
M54.09 Panniculitis affecting regions of neck and back (Site unspecified)	0.451	0.549	0.000
M54.08 Panniculitis affecting regions of neck and back (Sacral and sacrococcygeal region)	0.451	0.549	0.000
M54.07 Panniculitis affecting regions of neck and back (Lumbosacral region)	0.451	0.549	0.000
M54.06 Panniculitis affecting regions of neck and back (Lumbar region)	0.451	0.549	0.000
M54.05 Panniculitis affecting regions of neck and back (Thoracolumbar region)	0.451	0.549	0.000
M54.04 Panniculitis affecting regions of neck and back (Thoracic region)	0.451	0.549	0.000
M54.03 Panniculitis affecting regions of neck and back (Cervicothoracic region)	0.451	0.549	0.000
M54.02 Panniculitis affecting regions of neck and back (Cervical region)	0.451	0.549	0.000
M54.01 Panniculitis affecting regions of neck and back (Occipito-atlanto-axial region)	0.451	0.549	0.000
M54.00 Panniculitis affecting regions of neck and back (Multiple sites in spine)	0.451	0.549	0.000
M54.89 Other dorsalgia (Site unspecified)	0.451	0.549	0.000
M54.88 Other dorsalgia (Sacral and sacrococcygeal region)	0.451	0.549	0.000
M54.87 Other dorsalgia (Lumbosacral region)	0.451	0.549	0.000
M54.86 Other dorsalgia (Lumbar region)	0.451	0.549	0.000
M54.85 Other dorsalgia (Thoracolumbar region)	0.451	0.549	0.000
M54.84 Other dorsalgia (Thoracic region)	0.451	0.549	0.000
M54.83 Other dorsalgia (Cervicothoracic region)	0.451	0.549	0.000
M54.82 Other dorsalgia (Cervical region)	0.451	0.549	0.000
M54.81 Other dorsalgia (Occipito-atlanto-axial region)	0.451	0.549	0.000
M54.80 Other dorsalgia (Multiple sites in spine)	0.451	0.549	0.000
M24.4 Recurrent dislocation and subluxation of joint	0.451	0.549	0.000
M25.64 Stiffness of joint, not elsewhere classified (Hand)	0.451	0.549	0.000
M71.3 Other bursal cyst	0.449	0.550	0.001
M42 Spinal osteochondrosis	0.443	0.550	0.006
M23.2 Derangement of meniscus due to old tear or injury	0.450	0.550	0.000
M92 Other juvenile osteochondrosis	0.442	0.551	0.008
M91 Juvenile osteochondrosis of hip and pelvis	0.442	0.551	0.008
M53.9 Dorsopathy, unspecified	0.448	0.551	0.002
M53.8 Other specified dorsopathies	0.448	0.551	0.002
M53.2 Spinal instabilities	0.448	0.551	0.002
M53.1 Cervicobrachial syndrome	0.448	0.551	0.002
M53.0 Cervicocranial syndrome	0.448	0.551	0.002
M21.0 Valgus deformity, not elsewhere classified	0.449	0.551	0.000
M21.4 Flat foot [pes planus] (acquired)	0.448	0.551	0.000
M18.5 Other secondary arthrosis of first carpometacarpal joint	0.446	0.553	0.000
M18.4 Other secondary arthrosis of first carpometacarpal joints, bilateral	0.446	0.553	0.000
M18.3 Other posttraumatic arthrosis of first carpometacarpal joint	0.446	0.553	0.000
M18.2 Posttraumatic arthrosis of first carpometacarpal joints, bilateral	0.446	0.553	0.000
M79.19 Myalgia (Site unspecified)	0.446	0.554	0.000
M87.9 Osteonecrosis, unspecified	0.443	0.554	0.004
M94 Other disorders of cartilage	0.439	0.554	0.007
M79.17 Myalgia (Ankle and foot)	0.444	0.556	0.000
M79.16 Myalgia (Lower leg)	0.444	0.556	0.000
M79.15 Myalgia (Pelvic region and thigh)	0.444	0.556	0.000
M79.14 Myalgia (Hand)	0.444	0.556	0.000
M79.13 Myalgia (Forearm)	0.444	0.556	0.000
M79.12 Myalgia (Upper arm)	0.444	0.556	0.000
M79.11 Myalgia (Shoulder region)	0.444	0.556	0.000
M79.10 Myalgia (Multiple sites)	0.444	0.556	0.000
M08.9 Juvenile arthritis, unspecified	0.364	0.556	0.079
M08.8 Other juvenile arthritis	0.364	0.556	0.079
M08.4 Pauciarticular juvenile arthritis	0.364	0.556	0.079
M08.3 Juvenile polyarthritis (seronegative)	0.364	0.556	0.079
M08.2 Juvenile arthritis with systemic onset	0.364	0.556	0.079

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations