TreeWAS – Variant ID: rs12117978

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
D68.2 Hereditary deficiency of other clotting factors	1.000	0.000	0.000
D68 Other coagulation defects	0.980	0.020	0.000
Z86.7 Personal history of diseases of the circulatory system	0.980	0.020	0.000
I80.2 Phlebitis and thrombophlebitis of other deep vessels of lower extremities	0.959	0.041	0.000
D68.5 Primary Thrombophilia	0.920	0.080	0.000
I80 Phlebitis and thrombophlebitis	0.876	0.124	0.000
D68.9 Coagulation defect, unspecified	0.827	0.173	0.000
D68.3 Haemorrhagic disorder due to circulating anticoagulants	0.800	0.199	0.000
D68.8 Other specified coagulation defects	0.798	0.202	0.000
I80.3 Phlebitis and thrombophlebitis of lower extremities, unspecified	0.790	0.210	0.000
I80.1 Phlebitis and thrombophlebitis of femoral vein	0.775	0.225	0.000
D68.6 Other Thrombophilia	0.773	0.227	0.000
I80.9 Phlebitis and thrombophlebitis of unspecified site	0.735	0.265	0.000
D68.0 Von Willebrand's disease	0.728	0.272	0.000
I80.0 Phlebitis and thrombophlebitis of superficial vessels of lower extremities	0.715	0.285	0.000
D68.4 Acquired coagulation factor deficiency	0.703	0.297	0.000
D68.1 Hereditary factor XI deficiency	0.703	0.297	0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions	0.570	0.430	0.000
I80.8 Phlebitis and thrombophlebitis of other sites	0.520	0.480	0.000
D67 Hereditary factor IX deficiency	0.408	0.591	0.000
D65 Disseminated intravascular coagulation [defibrination syndrome]	0.408	0.591	0.000
D69 Purpura and other haemorrhagic conditions	0.403	0.597	0.000
D66 Hereditary factor VIII deficiency	0.399	0.601	0.000
D69.3 Idiopathic thrombocytopenic purpura	0.314	0.686	0.000
D69.9 Haemorrhagic condition, unspecified	0.305	0.695	0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	0.300	0.700	0.000
D69.5 Secondary thrombocytopenia	0.293	0.707	0.000
D69.8 Other specified haemorrhagic conditions	0.289	0.711	0.000
D69.4 Other primary thrombocytopenia	0.289	0.711	0.000
D69.2 Other nonthrombocytopenic purpura	0.289	0.711	0.000
D69.1 Qualitative platelet defects	0.289	0.711	0.000
D69.0 Allergic purpura	0.289	0.711	0.000
D80-D89 Certain disorders involving the immune mechanism	0.284	0.716	0.000
D86 Sarcoidosis	0.256	0.744	0.000
D70-D77 Other diseases of blood and blood-forming organs	0.233	0.767	0.000
D55-D59 Haemolytic anaemias	0.230	0.769	0.000
D84 Other immunodeficiencies	0.228	0.772	0.000
D69.6 Thrombocytopenia, unspecified	0.221	0.779	0.000
D80 Immunodeficiency with predominantly antibody defects	0.220	0.780	0.000
D89 Other disorders involving the immune mechanism, not elsewhere classified	0.220	0.780	0.000
D86.1 Sarcoidosis of lymph nodes	0.219	0.781	0.000
D86.9 Sarcoidosis, unspecified	0.212	0.788	0.000
D83 Common variable immunodeficiency	0.204	0.796	0.000
D82 Immunodeficiency associated with other major defects	0.204	0.796	0.000
D81 Combined immunodeficiencies	0.204	0.796	0.000
D86.8 Sarcoidosis of other and combined sites	0.194	0.805	0.000
D84.9 Immunodeficiency, unspecified	0.189	0.811	0.000
D76 Certain diseases involving lymphoreticular tissue and reticulohistiocytic system	0.185	0.815	0.000
D58 Other hereditary haemolytic anaemias	0.184	0.816	0.000
D86.3 Sarcoidosis of skin	0.184	0.816	0.000
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes	0.184	0.816	0.000
D73 Diseases of spleen	0.184	0.816	0.000
D75 Other diseases of blood and blood-forming organs	0.181	0.819	0.000
D86.0 Sarcoidosis of lung	0.181	0.819	0.000
D72 Other disorders of white blood cells	0.178	0.822	0.000
D80.1 Nonfamilial hypogammaglobulinaemia	0.175	0.825	0.000
D89.2 Hypergammaglobulinaemia, unspecified	0.175	0.825	0.000
D74 Methaemoglobinaemia	0.167	0.833	0.000
D77 Other disorders of blood and blood-forming organs in diseases classified elsewhere	0.167	0.833	0.000
D71 Functional disorders of polymorphonuclear neutrophils	0.167	0.833	0.000
D57 Sickle-cell disorders	0.165	0.834	0.000
D56 Thalassaemia	0.165	0.834	0.000
D55 Anaemia due to enzyme disorders	0.165	0.834	0.000
D84.8 Other specified immunodeficiencies	0.164	0.836	0.000
D84.1 Defects in the complement system	0.164	0.836	0.000
D84.0 Lymphocyte function antigen-1 [LFA-1] defect	0.164	0.836	0.000
D59 Acquired haemolytic anaemia	0.160	0.840	0.000
D80.9 Immunodeficiency with predominantly antibody defects, unspecified	0.158	0.842	0.000
D80.8 Other immunodeficiencies with predominantly antibody defects	0.158	0.842	0.000
D80.7 Transient hypogammaglobulinaemia of infancy	0.158	0.842	0.000
D80.6 Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinaemia	0.158	0.842	0.000
D80.5 Immunodeficiency with increased immunoglobulin M [IgM]	0.158	0.842	0.000
D80.4 Selective deficiency of immunoglobulin M [IgM]	0.158	0.842	0.000
D80.3 Selective deficiency of immunoglobulin G [IgG] subclasses	0.158	0.842	0.000
D80.2 Selective deficiency of immunoglobulin A [IgA]	0.158	0.842	0.000
D80.0 Hereditary hypogammaglobulinaemia	0.158	0.842	0.000
D89.9 Disorder involving the immune mechanism, unspecified	0.158	0.842	0.000
D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified	0.158	0.842	0.000
D89.3 Immune reconstitution syndrome	0.158	0.842	0.000
D89.1 Cryoglobulinaemia	0.158	0.842	0.000
D89.0 Polyclonal hypergammaglobulinaemia	0.158	0.842	0.000
D58.0 Hereditary spherocytosis	0.151	0.849	0.000
D76.3 Other histiocytosis syndromes	0.150	0.850	0.000
D73.0 Hyposplenism	0.149	0.851	0.000
D81.9 Combined immunodeficiency, unspecified	0.146	0.854	0.000
D81.8 Other combined immunodeficiencies	0.146	0.854	0.000
D81.7 Major histocompatibility complex class II deficiency	0.146	0.854	0.000
D81.6 Major histocompatibility complex class I deficiency	0.146	0.854	0.000
D81.5 Purine nucleoside phosphorylase [PNP] deficiency	0.146	0.854	0.000
D81.4 Nezelof's syndrome	0.146	0.854	0.000
D81.3 Adenosine deaminase [ADA] deficiency	0.146	0.854	0.000
D81.2 Severe combined immunodeficiency [SCID] with low or normal B-cell numbers	0.146	0.854	0.000
D81.1 Severe combined immunodeficiency [SCID] with low T- and B-cell numbers	0.146	0.854	0.000
D81.0 Severe combined immunodeficiency [SCID] with reticular dysgenesis	0.146	0.854	0.000
D82.9 Immunodeficiency associated with major defect, unspecified	0.146	0.854	0.000
D82.8 Immunodeficiency associated with other specified major defects	0.146	0.854	0.000
D82.4 Hyperimmunoglobulin E [IgE] syndrome	0.146	0.854	0.000
D82.3 Immunodeficiency following hereditary defective response to Epstein-Barr virus	0.146	0.854	0.000
D82.2 Immunodeficiency with short-limbed stature	0.146	0.854	0.000
D82.1 Di George's syndrome	0.146	0.854	0.000
D82.0 Wiskott-Aldrich syndrome	0.146	0.854	0.000
D83.9 Common variable immunodeficiency, unspecified	0.146	0.854	0.000
D83.8 Other common variable immunodeficiencies	0.146	0.854	0.000
D83.2 Common variable immunodeficiency with autoantibodies to B- or T-cells	0.146	0.854	0.000
D83.1 Common variable immunodeficiency with predominant immunoregulatory T-cell disorders	0.146	0.854	0.000
D83.0 Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function	0.146	0.854	0.000
D75.8 Other specified diseases of blood and blood-forming organs	0.140	0.860	0.000
D72.8 Other specified disorders of white blood cells	0.139	0.861	0.000
D75.1 Secondary polycythaemia	0.135	0.865	0.000
D75.9 Disease of blood and blood-forming organs, unspecified	0.134	0.866	0.000
D76.2 Haemophagocytic syndrome, infection-associated	0.132	0.867	0.000
D76.1 Haemophagocytic lymphohistiocytosis	0.132	0.867	0.000
D76.0 Langerhans' cell histiocytosis, not elsewhere classified	0.132	0.867	0.000
D58.9 Hereditary haemolytic anaemia, unspecified	0.132	0.868	0.000
D58.8 Other specified hereditary haemolytic anaemias	0.132	0.868	0.000
D58.2 Other haemoglobinopathies	0.132	0.868	0.000
D58.1 Hereditary elliptocytosis	0.132	0.868	0.000
D73.9 Disease of spleen, unspecified	0.132	0.868	0.000
D73.8 Other diseases of spleen	0.132	0.868	0.000
D73.5 Infarction of spleen	0.132	0.868	0.000
D73.4 Cyst of spleen	0.132	0.868	0.000
D73.3 Abscess of spleen	0.132	0.868	0.000
D73.2 Chronic congestive splenomegaly	0.132	0.868	0.000
D73.1 Hypersplenism	0.132	0.868	0.000
D75.0 Familial erythrocytosis	0.130	0.870	0.000
D60-D64 Aplastic and other anaemias	0.128	0.872	0.000
D72.1 Eosinophilia	0.128	0.872	0.000
D72.9 Disorder of white blood cells, unspecified	0.128	0.872	0.000
D72.0 Genetic anomalies of leukocytes	0.128	0.872	0.000
D75.2 Essential thrombocytosis	0.126	0.873	0.000
D74.9 Methaemoglobinaemia, unspecified	0.120	0.880	0.000
D74.8 Other methaemoglobinaemias	0.120	0.880	0.000
D74.0 Congenital methaemoglobinaemia	0.120	0.880	0.000
D55.9 Anaemia due to enzyme disorder, unspecified	0.119	0.881	0.000
D55.8 Other anaemias due to enzyme disorders	0.119	0.881	0.000
D55.3 Anaemia due to disorders of nucleotide metabolism	0.119	0.881	0.000
D55.2 Anaemia due to disorders of glycolytic enzymes	0.119	0.881	0.000
D55.1 Anaemia due to other disorders of glutathione metabolism	0.119	0.881	0.000
D55.0 Anaemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiency	0.119	0.881	0.000
D56.9 Thalassaemia, unspecified	0.119	0.881	0.000
D56.8 Other thalassaemias	0.119	0.881	0.000
D56.4 Hereditary persistence of foetal haemoglobin [HPFH]	0.119	0.881	0.000
D56.3 Thalassaemia trait	0.119	0.881	0.000
D56.2 Delta-beta thalassaemia	0.119	0.881	0.000
D56.1 Beta thalassaemia	0.119	0.881	0.000
D56.0 Alpha thalassaemia	0.119	0.881	0.000
D57.8 Other sickle-cell disorders	0.119	0.881	0.000
D57.3 Sickle-cell trait	0.119	0.881	0.000
D57.2 Double heterozygous sickling disorders	0.119	0.881	0.000
D57.1 Sickle-cell anaemia without crisis	0.119	0.881	0.000
D57.0 Sickle-cell anaemia with crisis	0.119	0.881	0.000
Z86 Personal history of certain other diseases	0.116	0.884	0.000
D59.9 Acquired haemolytic anaemia, unspecified	0.115	0.885	0.000
D59.8 Other acquired haemolytic anaemias	0.115	0.885	0.000
D59.6 Haemoglobinuria due to haemolysis from other external causes	0.115	0.885	0.000
D59.5 Paroxysmal nocturnal haemoglobinuria [Marchiafava-Micheli]	0.115	0.885	0.000
D59.4 Other nonautoimmune haemolytic anaemias	0.115	0.885	0.000
D59.3 Haemolytic-uraemic syndrome	0.115	0.885	0.000
D59.2 Drug-induced nonautoimmune haemolytic anaemia	0.115	0.885	0.000
D59.0 Drug-induced autoimmune haemolytic anaemia	0.115	0.885	0.000
D59.1 Other autoimmune haemolytic anaemias	0.110	0.890	0.000
D61 Other aplastic anaemias	0.106	0.894	0.000
Z86.5 Personal history of other mental and behavioural disorders	0.103	0.897	0.000
D50-D53 Nutritional anaemias	0.097	0.902	0.001
D70 Agranulocytosis	0.096	0.904	0.000
D60 Acquired pure red cell aplasia [erythroblastopenia]	0.092	0.908	0.000
D61.9 Aplastic anaemia, unspecified	0.090	0.910	0.000
Z86.0 Personal history of other neoplasms	0.088	0.912	0.000
Z86.2 Personal history of diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	0.082	0.918	0.000
Z86.3 Personal history of endocrine, nutritional and metabolic diseases	0.079	0.921	0.000
D61.8 Other specified aplastic anaemias	0.076	0.924	0.000
D61.3 Idiopathic aplastic anaemia	0.076	0.924	0.000
D61.2 Aplastic anaemia due to other external agents	0.076	0.924	0.000
D61.1 Drug-induced aplastic anaemia	0.076	0.924	0.000
D61.0 Constitutional aplastic anaemia	0.076	0.924	0.000
D62 Acute posthaemorrhagic anaemia	0.074	0.926	0.000
D53 Other nutritional anaemias	0.070	0.929	0.001
D52 Folate deficiency anaemia	0.069	0.930	0.001
I80-I89 Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified	0.068	0.932	0.000
D60.9 Acquired pure red cell aplasia, unspecified	0.066	0.934	0.000
D60.8 Other acquired pure red cell aplasias	0.066	0.934	0.000
D60.1 Transient acquired pure red cell aplasia	0.066	0.934	0.000
D60.0 Chronic acquired pure red cell aplasia	0.066	0.934	0.000
D63 Anaemia in chronic diseases classified elsewhere	0.063	0.937	0.000
I83 Varicose veins of lower extremities	0.056	0.944	0.000
Z86.1 Personal history of infectious and parasitic diseases	0.056	0.944	0.000
D64 Other anaemias	0.054	0.946	0.000
D51 Vitamin B12 deficiency anaemia	0.052	0.947	0.001
Z86.6 Personal history of diseases of the nervous system and sense organs	0.052	0.948	0.000
I83.0 Varicose veins of lower extremities with ulcer	0.052	0.948	0.000
D53.9 Nutritional anaemia, unspecified	0.050	0.949	0.001
D53.8 Other specified nutritional anaemias	0.050	0.949	0.001
D53.2 Scorbutic anaemia	0.050	0.949	0.001
D53.1 Other megaloblastic anaemias, not elsewhere classified	0.050	0.949	0.001
D53.0 Protein deficiency anaemia	0.050	0.949	0.001
D52.8 Other folate deficiency anaemias	0.050	0.949	0.001
D52.1 Drug-induced folate deficiency anaemia	0.050	0.949	0.001
D52.0 Dietary folate deficiency anaemia	0.050	0.949	0.001
D52.9 Folate deficiency anaemia, unspecified	0.050	0.950	0.001
I81 Portal vein thrombosis	0.050	0.950	0.000
I88 Nonspecific lymphadenitis	0.049	0.951	0.000
I83.1 Varicose veins of lower extremities with inflammation	0.047	0.953	0.000
I87 Other disorders of veins	0.047	0.953	0.000
I82 Other venous embolism and thrombosis	0.046	0.954	0.000
D63.1 Anaemia in other chronic diseases classified elsewhere	0.045	0.955	0.000
I86 Varicose veins of other sites	0.042	0.958	0.000
I89 Other non-infective disorders of lymphatic vessels and lymph nodes	0.040	0.959	0.000
I83.2 Varicose veins of lower extremities with both ulcer and inflammation	0.040	0.959	0.000
D51.9 Vitamin B12 deficiency anaemia, unspecified	0.039	0.960	0.001
D64.8 Other specified anaemias	0.039	0.961	0.000
D64.4 Congenital dyserythropoietic anaemia	0.039	0.961	0.000
D64.3 Other sideroblastic anaemias	0.039	0.961	0.000
D64.2 Secondary sideroblastic anaemia due to drugs and toxins	0.039	0.961	0.000
D64.1 Secondary sideroblastic anaemia due to disease	0.039	0.961	0.000
D64.0 Hereditary sideroblastic anaemia	0.039	0.961	0.000
D63.0 Anaemia in neoplastic disease	0.038	0.961	0.000
D51.8 Other vitamin B12 deficiency anaemias	0.037	0.962	0.001
D51.3 Other dietary vitamin B12 deficiency anaemia	0.037	0.962	0.001
D51.2 Transcobalamin II deficiency	0.037	0.962	0.001
D51.1 Vitamin B12 deficiency anaemia due to selective vitamin B12 malabsorption with proteinuria	0.037	0.962	0.001
I87.8 Other specified disorders of veins	0.038	0.962	0.000
I85 Oesophageal varices	0.038	0.962	0.000
I88.9 Nonspecific lymphadenitis, unspecified	0.035	0.965	0.000
I88.8 Other nonspecific lymphadenitis	0.035	0.965	0.000
I88.1 Chronic lymphadenitis, except mesenteric	0.035	0.965	0.000
I88.0 Nonspecific mesenteric lymphadenitis	0.035	0.965	0.000
I82.2 Embolism and thrombosis of vena cava	0.035	0.965	0.000
I87.9 Disorder of vein, unspecified	0.034	0.966	0.000
I87.0 Postphlebitic syndrome	0.034	0.966	0.000
I82.8 Embolism and thrombosis of other specified veins	0.033	0.967	0.000
I82.3 Embolism and thrombosis of renal vein	0.033	0.967	0.000
I82.1 Thrombophlebitis migrans	0.033	0.967	0.000
I82.0 Budd-Chiari syndrome	0.033	0.967	0.000
I89.9 Non-infective disorder of lymphatic vessels and lymph nodes, unspecified	0.032	0.967	0.000
I87.2 Venous insufficiency (chronic) (peripheral)	0.032	0.967	0.000
I86.8 Varicose veins of other specified sites	0.031	0.968	0.000
I86.3 Vulval varices	0.030	0.970	0.000
I86.2 Pelvic varices	0.030	0.970	0.000
I86.0 Sublingual varices	0.030	0.970	0.000
D63.8 Anaemia in other chronic diseases classified elsewhere	0.028	0.971	0.001
I85.0 Oesophageal varices with bleeding	0.027	0.973	0.000
I89.8 Other specified non-infective disorders of lymphatic vessels and lymph nodes	0.027	0.973	0.000
I86.1 Scrotal varices	0.027	0.973	0.000
I82.9 Embolism and thrombosis of unspecified vein	0.026	0.974	0.000
I87.1 Compression of vein	0.026	0.974	0.000
I86.4 Gastric varices	0.026	0.974	0.000
I89.1 Lymphangitis	0.026	0.974	0.000
I89.0 Lymphoedema, not elsewhere classified	0.022	0.977	0.000
D51.0 Vitamin B12 deficiency anaemia due to intrinsic factor deficiency	0.016	0.983	0.001
I85.9 Oesophageal varices without bleeding	0.016	0.984	0.000
H40.1 Primary open-angle glaucoma	0.013	0.987	0.000
R14 Flatulence and related conditions	0.000	0.987	0.013
H40 Glaucoma	0.013	0.987	0.000
H40.8 Other glaucoma	0.012	0.988	0.000
H40.2 Primary angle-closure glaucoma	0.011	0.989	0.000
H40.0 Glaucoma suspect	0.011	0.989	0.000
H40.9 Glaucoma, unspecified	0.011	0.989	0.000
I83.9 Varicose veins of lower extremities without ulcer or inflammation	0.011	0.989	0.000
D50 Iron deficiency anaemia	0.008	0.989	0.003
R27.0 Ataxia, unspecified	0.011	0.989	0.000
R26.8 Other and unspecified abnormalities of gait and mobility	0.010	0.990	0.000
R27 Other lack of coordination	0.010	0.990	0.000
R26 Abnormalities of gait and mobility	0.010	0.990	0.000
R25-R29 Symptoms and signs involving the nervous and musculoskeletal systems	0.010	0.990	0.000
H40.6 Glaucoma secondary to drugs	0.009	0.991	0.000
H40.4 Glaucoma secondary to eye inflammation	0.009	0.991	0.000
H40.3 Glaucoma secondary to eye trauma	0.009	0.991	0.000
R26.0 Ataxic gait	0.009	0.991	0.000
R29 Other symptoms and signs involving the nervous and musculoskeletal systems	0.009	0.991	0.000
R29.6 Tendency to fall, not elsewhere classified	0.008	0.992	0.000
R27.8 Other and unspecified lack of coordination	0.008	0.992	0.000
H40.5 Glaucoma secondary to other eye disorders	0.008	0.992	0.000
D50.1 Sideropenic dysphagia	0.006	0.992	0.002
R29.8 Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems	0.008	0.992	0.000
R26.1 Paralytic gait	0.007	0.993	0.000
R25 Abnormal involuntary movements	0.007	0.993	0.000
R26.3 Immobility	0.007	0.993	0.000
R29.4 Clicking hip	0.007	0.993	0.000
R29.3 Abnormal posture	0.007	0.993	0.000
R29.2 Abnormal reflex	0.007	0.993	0.000
R29.1 Meningismus	0.007	0.993	0.000
R29.0 Tetany	0.007	0.993	0.000
R19.0 Intra-abdominal and pelvic swelling, mass and lump	0.000	0.993	0.007
H60 Otitis externa	0.006	0.994	0.000
H60.9 Otitis externa, unspecified	0.006	0.994	0.000
H60.5 Acute otitis externa, non-infective	0.006	0.994	0.000
R25.8 Other and unspecified abnormal involuntary movements	0.006	0.994	0.000
H40-H42 Glaucoma	0.006	0.994	0.000
R25.1 Tremor, unspecified	0.005	0.994	0.000
H60.3 Other infective otitis externa	0.005	0.995	0.000
R25.0 Abnormal head movements	0.005	0.995	0.000
H60.8 Other otitis externa	0.005	0.995	0.000
R25.3 Fasciculation	0.005	0.995	0.000
D50.0 Iron deficiency anaemia secondary to blood loss (chronic)	0.002	0.995	0.003
J84.1 Other interstitial pulmonary diseases with fibrosis	0.005	0.995	0.000
Z92.1 Personal history of long-term (current) use of anticoagulants	0.005	0.995	0.000
H60.1 Cellulitis of external ear	0.005	0.995	0.000
D17.2 Benign lipomatous neoplasm of skin and subcutaneous tissue of limbs	0.005	0.995	0.000
H60.4 Cholesteatoma of external ear	0.005	0.995	0.000
H60.2 Malignant otitis externa	0.005	0.995	0.000
H60.0 Abscess of external ear	0.005	0.995	0.000
R25.2 Cramp and spasm	0.005	0.995	0.000
R26.2 Difficulty in walking, not elsewhere classified	0.004	0.995	0.001
H60-H62 Diseases of external ear	0.004	0.996	0.000
H42 Glaucoma in diseases classified elsewhere	0.004	0.996	0.000
K66.0 Peritoneal adhesions	0.000	0.996	0.004
H61.0 Perichondritis of external ear	0.004	0.996	0.000
H61 Other disorders of external ear	0.004	0.996	0.000
J84 Other interstitial pulmonary diseases	0.004	0.996	0.000
R52.1 Chronic intractable pain	0.000	0.996	0.004
D50.8 Other iron deficiency anaemias	0.001	0.996	0.003
J84.9 Interstitial pulmonary disease, unspecified	0.004	0.996	0.000
R19 Other symptoms and signs involving the digestive system and abdomen	0.000	0.996	0.004
H62 Disorders of external ear in diseases classified elsewhere	0.003	0.997	0.000
H42.8 Glaucoma in other diseases classified elsewhere	0.003	0.997	0.000
H42.0 Glaucoma in endocrine, nutritional and metabolic diseases	0.003	0.997	0.000
M43.16 Spondylolisthesis (Lumbar region)	0.003	0.997	0.000
H61.1 Non-infective disorders of pinna	0.003	0.997	0.000
N20.1 Calculus of ureter	0.003	0.997	0.000
H61.9 Disorder of external ear, unspecified	0.003	0.997	0.000
H61.3 Acquired stenosis of external ear canal	0.003	0.997	0.000
R19.5 Other fecal abnormalities	0.000	0.997	0.003
M48.06 Spinal stenosis (Lumbar region)	0.003	0.997	0.000
J84.8 Other specified interstitial pulmonary diseases	0.003	0.997	0.000
J84.0 Alveolar and parietoalveolar conditions	0.003	0.997	0.000
E05.9 Thyrotoxicosis, unspecified	0.000	0.997	0.003
H61.2 Impacted cerumen	0.003	0.997	0.000
H61.8 Other specified disorders of external ear	0.003	0.997	0.000
N13.3 Other and unspecified hydronephrosis	0.000	0.997	0.003
R52.2 Other chronic pain	0.000	0.997	0.003
R52 Pain, not elsewhere classified	0.000	0.997	0.003
R19.6 Halitosis	0.000	0.997	0.003
R19.3 Abdominal rigidity	0.000	0.997	0.003
R19.2 Visible peristalsis	0.000	0.997	0.003
R19.1 Abnormal bowel sounds	0.000	0.997	0.003
K66 Other disorders of peritoneum	0.000	0.997	0.003
H62.8 Other disorders of external ear in diseases classified elsewhere	0.003	0.997	0.000
H62.4 Otitis externa in other diseases classified elsewhere	0.003	0.997	0.000
H62.3 Otitis externa in other infectious and parasitic diseases classified elsewhere	0.003	0.997	0.000
H62.2 Otitis externa in mycoses	0.003	0.997	0.000
H62.1 Otitis externa in viral diseases classified elsewhere	0.003	0.997	0.000
H62.0 Otitis externa in bacterial diseases classified elsewhere	0.003	0.997	0.000
R22.1 Localised swelling, mass and lump, neck	0.000	0.997	0.003
E05.0 Thyrotoxicosis with diffuse goitre	0.000	0.997	0.003
I26.9 Pulmonary embolism without mention of acute cor pulmonale	0.003	0.997	0.000
R52.9 Pain, unspecified	0.000	0.997	0.003
R19.8 Other specified symptoms and signs involving the digestive system and abdomen	0.000	0.997	0.003
R22.4 Localised swelling, mass and lump, lower limb	0.000	0.998	0.002
K66.8 Other specified disorders of peritoneum	0.000	0.998	0.002
R10-R19 Symptoms and signs involving the digestive system and abdomen	0.000	0.998	0.002
K66.9 Disorder of peritoneum, unspecified	0.000	0.998	0.002
K66.1 Haemoperitoneum	0.000	0.998	0.002
E05 Thyrotoxicosis [hyperthyroidism]	0.000	0.998	0.002
R11 Nausea and vomiting	0.000	0.998	0.002
H53.0 Amblyopia ex anopsia	0.002	0.998	0.000
R52.0 Acute pain	0.000	0.998	0.002
M23.83 Other internal derangements of knee (Medial collateral ligament or Other and unspecified medial meniscus)	0.002	0.998	0.000
R22.0 Localised swelling, mass and lump, head	0.000	0.998	0.002
S00.9 Superficial injury of head, part unspecified	0.002	0.998	0.000
N13 Obstructive and reflux uropathy	0.000	0.998	0.002
M23.81 Other internal derangements of knee (Anterior cruciate ligament or Anterior horn of medial meniscus)	0.002	0.998	0.000
R18 Ascites	0.000	0.998	0.002
I08.0 Disorders of both mitral and aortic valves	0.000	0.998	0.002
Z93.3 Colostomy status	0.000	0.998	0.002
K91.8 Other postprocedural disorders of digestive system, not elsewhere classified	0.000	0.998	0.002
Z92.6 Personal history of chemotherapy for neoplastic disease	0.002	0.998	0.000
Z92.4 Personal history of major surgery, not elsewhere classified	0.002	0.998	0.000
S00.8 Superficial injury of other parts of head	0.002	0.998	0.000
R22 Localised swelling, mass and lump of skin and subcutaneous tissue	0.000	0.998	0.002
S00 Superficial injury of head	0.002	0.998	0.000
M79.86 Other specified soft tissue disorders (Lower leg)	0.002	0.998	0.000
G55.1 Nerve root and plexus compressions in intervertebral disk disorders	0.002	0.998	0.000
I08.3 Combined disorders of mitral, aortic and tricuspid valves	0.000	0.998	0.002
I42.0 Dilated cardiomyopathy	0.002	0.998	0.000
N13.5 Kinking and stricture of ureter without hydronephrosis	0.000	0.998	0.002
L53.9 Erythematous condition, unspecified	0.002	0.998	0.000
H53.4 Visual field defects	0.002	0.998	0.000
J80-J84 Other respiratory diseases principally affecting the interstitium	0.002	0.998	0.000
M43.1 Spondylolisthesis	0.002	0.998	0.000
E05.8 Other thyrotoxicosis	0.000	0.998	0.002
E05.5 Thyroid crisis or storm	0.000	0.998	0.002
E05.4 Thyrotoxicosis factitia	0.000	0.998	0.002
E05.3 Thyrotoxicosis from ectopic thyroid tissue	0.000	0.998	0.002
E05.1 Thyrotoxicosis with toxic single thyroid nodule	0.000	0.998	0.002
N13.9 Obstructive and reflux uropathy, unspecified	0.000	0.998	0.002
M80.00 Postmenopausal osteoporosis with pathological fracture (Multiple sites)	0.002	0.998	0.000
S00.1 Contusion of eyelid and periocular area	0.002	0.998	0.000
I08 Multiple valve diseases	0.000	0.998	0.002
N13.2 Hydronephrosis with renal and ureteral calculous obstruction	0.000	0.998	0.002
S00.2 Other superficial injuries of eyelid and periocular area	0.002	0.998	0.000
R17 Unspecified jaundice	0.000	0.998	0.002
N13.7 Vesicoureteral-reflux-associated uropathy	0.000	0.998	0.002
N13.4 Hydroureter	0.000	0.998	0.002
D50.9 Iron deficiency anaemia, unspecified	0.000	0.998	0.001
I08.1 Disorders of both mitral and tricuspid valves	0.000	0.998	0.002
T40.2 Other opioids	0.000	0.998	0.002
K80.5 Calculus of bile duct without cholangitis or cholecystitis	0.000	0.998	0.002
S00.7 Multiple superficial injuries of head	0.002	0.998	0.000
Z01.8 Other specified special examinations	0.002	0.998	0.000
C78.2 Secondary malignant neoplasm of pleura	0.000	0.998	0.002
N13.1 Hydronephrosis with ureteral stricture, not elsewhere classified	0.000	0.998	0.002
Z92 Personal history of medical treatment	0.002	0.998	0.000
I21.9 Acute myocardial infarction, unspecified	0.000	0.998	0.002
M23.8 Other internal derangements of knee	0.002	0.998	0.000
S00.3 Superficial injury of nose	0.002	0.998	0.000
Z80.4 Family history of malignant neoplasm of genital organs	0.002	0.998	0.000
E05.2 Thyrotoxicosis with toxic multinodular goitre	0.000	0.998	0.002
R22.7 Localised swelling, mass and lump, multiple sites	0.000	0.998	0.002
R41.8 Other and unspecified symptoms and signs involving cognitive functions and awareness	0.002	0.998	0.000
N10 Acute tubulo-interstitial nephritis	0.000	0.998	0.002
S00.5 Superficial injury of lip and oral cavity	0.002	0.998	0.000
S00.4 Superficial injury of ear	0.002	0.998	0.000
J81 Pulmonary oedema	0.002	0.998	0.000
N13.8 Other obstructive and reflux uropathy	0.000	0.998	0.002
M23.86 Other internal derangements of knee (Other and unspecified lateral meniscus)	0.002	0.998	0.000
S00.0 Superficial injury of scalp	0.002	0.998	0.000
J80 Adult respiratory distress syndrome	0.002	0.998	0.000
M23.82 Other internal derangements of knee (Posterior cruciate ligament or Posterior horn of medial meniscus)	0.002	0.998	0.000
C78.8 Secondary malignant neoplasm of other and unspecified digestive organs	0.000	0.998	0.002
J82 Pulmonary eosinophilia, not elsewhere classified	0.002	0.998	0.000
H65-H75 Diseases of middle ear and mastoid	0.002	0.998	0.000
Chapter VIII Diseases of the ear and mastoid process	0.002	0.998	0.000
M43.19 Spondylolisthesis (Site unspecified)	0.001	0.998	0.000
M43.18 Spondylolisthesis (Sacral and sacrococcygeal region)	0.001	0.998	0.000
M43.15 Spondylolisthesis (Thoracolumbar region)	0.001	0.998	0.000
M43.14 Spondylolisthesis (Thoracic region)	0.001	0.998	0.000
M43.13 Spondylolisthesis (Cervicothoracic region)	0.001	0.998	0.000
M43.12 Spondylolisthesis (Cervical region)	0.001	0.998	0.000
M43.11 Spondylolisthesis (Occipito-atlanto-axial region)	0.001	0.998	0.000
M43.10 Spondylolisthesis (Multiple sites in spine)	0.001	0.998	0.000
F10.1 Harmful use	0.002	0.998	0.000
G37.9 Demyelinating disease of central nervous system, unspecified	0.002	0.998	0.000
N13.0 Hydronephrosis with ureteropelvic junction obstruction	0.000	0.998	0.002
R60.9 Oedema, unspecified	0.000	0.998	0.002
G35 Multiple sclerosis	0.002	0.998	0.000
M25.76 Osteophyte (Lower leg)	0.002	0.998	0.000
M96.0 Pseudarthrosis after fusion or arthrodesis	0.002	0.998	0.000
N13.6 Pyonephrosis	0.000	0.998	0.001
I26 Pulmonary embolism	0.002	0.998	0.000
I08.9 Multiple valve disease, unspecified	0.000	0.998	0.001
H53 Visual disturbances	0.002	0.998	0.000
R04.0 Epistaxis	0.000	0.998	0.002
R60.0 Localised oedema	0.000	0.998	0.002
N10-N16 Renal tubulo-interstitial diseases	0.000	0.998	0.002
I08.8 Other multiple valve diseases	0.000	0.998	0.001
N50.8 Other specified disorders of male genital organs	0.000	0.998	0.002
T50.9 Other and unspecified drugs, medicaments and biological substances	0.000	0.998	0.002
H65 Nonsuppurative otitis media	0.002	0.998	0.000
N12 Tubulo-interstitial nephritis, not specified as acute or chronic	0.000	0.998	0.002
H53.2 Diplopia	0.002	0.998	0.000
H65.9 Nonsuppurative otitis media, unspecified	0.002	0.998	0.000
I08.2 Disorders of both aortic and tricuspid valves	0.000	0.998	0.001
X62.9 Unspecified place	0.000	0.998	0.002
Z92.9 Personal history of medical treatment, unspecified	0.001	0.998	0.000
Z92.5 Personal history of rehabilitation measures	0.001	0.998	0.000
Z92.0 Personal history of contraception	0.001	0.998	0.000
H70 Mastoiditis and related conditions	0.001	0.998	0.000
H69 Other disorders of Eustachian tube	0.001	0.998	0.000
M23.87 Other internal derangements of knee (Capsular ligament)	0.001	0.998	0.000
M23.85 Other internal derangements of knee (Posterior horn of lateral meniscus)	0.001	0.998	0.000
M23.84 Other internal derangements of knee (Lateral collateral ligament or Anterior horn of lateral meniscus)	0.001	0.998	0.000
M23.80 Other internal derangements of knee (Multiple sites)	0.001	0.998	0.000
C78.7 Secondary malignant neoplasm of liver	0.000	0.998	0.002
H33.2 Serous retinal detachment	0.002	0.998	0.000
J32.9 Chronic sinusitis, unspecified	0.000	0.998	0.002
K51.2 Ulcerative (chronic) proctitis	0.000	0.998	0.002
K91.4 Colostomy and enterostomy malfunction	0.000	0.998	0.002
R22.2 Localised swelling, mass and lump, trunk	0.000	0.998	0.001
E23.0 Hypopituitarism	0.001	0.998	0.000
H74.0 Tympanosclerosis	0.001	0.998	0.000
K72.9 Hepatic failure, unspecified	0.000	0.998	0.001
C61 Malignant neoplasm of prostate	0.002	0.998	0.000
G37 Other demyelinating diseases of central nervous system	0.001	0.998	0.000
H73 Other disorders of tympanic membrane	0.001	0.998	0.000
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system	0.001	0.998	0.000
H70.9 Mastoiditis, unspecified	0.001	0.998	0.000
R22.9 Localised swelling, mass and lump, unspecified	0.000	0.998	0.001
H74 Other disorders of middle ear and mastoid	0.001	0.998	0.000
H69.9 Eustachian tube disorder, unspecified	0.001	0.998	0.000
H50.1 Divergent concomitant strabismus	0.001	0.999	0.000
K31.9 Disease of stomach and duodenum, unspecified	0.000	0.999	0.001
H75 Other disorders of middle ear and mastoid in diseases classified elsewhere	0.001	0.999	0.000
H68 Eustachian salpingitis and obstruction	0.001	0.999	0.000
H67 Otitis media in diseases classified elsewhere	0.001	0.999	0.000
I26.0 Pulmonary embolism with mention of acute cor pulmonale	0.001	0.999	0.000
K91.3 Postoperative intestinal obstruction	0.000	0.999	0.001
K65-K67 Diseases of peritoneum	0.000	0.999	0.001
H53.6 Night blindness	0.001	0.999	0.000
H53.5 Colour vision deficiencies	0.001	0.999	0.000
H53.3 Other disorders of binocular vision	0.001	0.999	0.000
H72.1 Attic perforation of tympanic membrane	0.001	0.999	0.000
I60.9 Subarachnoid haemorrhage, unspecified	0.000	0.999	0.001
K65.0 Acute peritonitis	0.000	0.999	0.001
Z93.6 Other artificial openings of urinary tract status	0.000	0.999	0.001
H65.3 Chronic mucoid otitis media	0.001	0.999	0.000
R22.3 Localised swelling, mass and lump, upper limb	0.000	0.999	0.001
T42.6 Other antiepileptic and sedative-hypnotic drugs	0.000	0.999	0.001
Z93.4 Other artificial openings of gastro-intestinal tract status	0.000	0.999	0.001
K91 Postprocedural disorders of digestive system, not elsewhere classified	0.000	0.999	0.001
H72 Perforation of tympanic membrane	0.001	0.999	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations