TreeWAS – Variant ID: rs12188351

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
O70 Perineal laceration during delivery	0.000	0.193	0.807
O70.0 First degree perineal laceration during delivery	0.000	0.201	0.799
O70.1 Second degree perineal laceration during delivery	0.000	0.203	0.797
O60-O75 Complications of labour and delivery	0.000	0.215	0.785
O63 Long labour	0.000	0.252	0.748
O69 Labour and delivery complicated by umbilical cord complications	0.000	0.306	0.694
O63.0 Prolonged first stage (of labour)	0.000	0.312	0.688
O70.2 Third degree perineal laceration during delivery	0.000	0.323	0.677
O72 Postpartum haemorrhage	0.000	0.324	0.676
O63.1 Prolonged second stage (of labour)	0.000	0.345	0.655
O62 Abnormalities of forces of labour	0.000	0.357	0.643
O69.1 Labour and delivery complicated by cord around neck, with compression	0.000	0.374	0.626
O64 Obstructed labour due to malposition and malpresentation of foetus	0.000	0.381	0.619
O75 Other complications of labour and delivery, not elsewhere classified	0.000	0.391	0.609
O61 Failed induction of labour	0.000	0.399	0.601
O70.3 Fourth degree perineal laceration during delivery	0.000	0.421	0.578
O69.2 Labour and delivery complicated by other cord entanglement	0.000	0.430	0.570
O74 Complications of anaesthesia during labour and delivery	0.000	0.437	0.563
O65 Obstructed labour due to maternal pelvic abnormality	0.000	0.437	0.563
O60 Preterm delivery	0.000	0.437	0.563
O62.2 Other uterine inertia	0.000	0.440	0.560
O72.2 Delayed and secondary postpartum haemorrhage	0.000	0.449	0.551
O66 Other obstructed labour	0.000	0.460	0.540
O64.0 Obstructed labour due to incomplete rotation of foetal head	0.000	0.463	0.537
O63.2 Delayed delivery of second twin, triplet, etc.	0.000	0.464	0.536
O70.9 Perineal laceration during delivery, unspecified	0.000	0.464	0.536
O68 Labour and delivery complicated by foetal stress [distress]	0.000	0.465	0.535
O72.1 Other immediate postpartum haemorrhage	0.000	0.466	0.534
O63.9 Long labour, unspecified	0.000	0.468	0.532
O73 Retained placenta and membranes, without haemorrhage	0.000	0.470	0.530
O72.0 Third-stage haemorrhage	0.000	0.486	0.514
O75.2 Pyrexia during labour, not elsewhere classified	0.000	0.499	0.501
O71 Other obstetric trauma	0.000	0.501	0.499
O67 Labour and delivery complicated by intrapartum haemorrhage, not elsewhere classified	0.000	0.501	0.498
O69.9 Labour and delivery complicated by cord complication, unspecified	0.000	0.503	0.497
O69.5 Labour and delivery complicated by vascular lesion of cord	0.000	0.503	0.497
O69.4 Labour and delivery complicated by vasa praevia	0.000	0.503	0.497
O69.3 Labour and delivery complicated by short cord	0.000	0.503	0.497
O69.0 Labour and delivery complicated by prolapse of cord	0.000	0.503	0.497
O72.3 Postpartum coagulation defects	0.000	0.515	0.484
O75.7 Vaginal delivery following previous Caesarean section	0.000	0.525	0.474
O61.0 Failed medical induction of labour	0.000	0.531	0.469
O62.9 Abnormality of forces of labour, unspecified	0.000	0.539	0.461
O62.8 Other abnormalities of forces of labour	0.000	0.539	0.461
O62.4 Hypertonic, incoordinate and prolonged uterine contractions	0.000	0.539	0.461
O62.3 Precipitate labour	0.000	0.539	0.461
O62.1 Secondary uterine inertia	0.000	0.539	0.461
O68.0 Labour and delivery complicated by foetal heart rate anomaly	0.000	0.544	0.456
O64.9 Obstructed labour due to malposition and malpresentation, unspecified	0.000	0.556	0.444
O64.8 Obstructed labour due to other malposition and malpresentation	0.000	0.556	0.444
O64.5 Obstructed labour due to compound presentation	0.000	0.556	0.444
O64.4 Obstructed labour due to shoulder presentation	0.000	0.556	0.444
O64.3 Obstructed labour due to brow presentation	0.000	0.556	0.444
O64.2 Obstructed labour due to face presentation	0.000	0.556	0.444
O75.8 Other specified complications of labour and delivery	0.000	0.561	0.439
O75.9 Complication of labour and delivery, unspecified	0.000	0.563	0.437
O75.5 Delayed delivery after artificial rupture of membranes	0.000	0.563	0.437
O75.4 Other complications of obstetric surgery and procedures	0.000	0.563	0.437
O75.3 Other infection during labour	0.000	0.563	0.437
O75.1 Shock during or following labour and delivery	0.000	0.563	0.437
O61.9 Failed induction of labour, unspecified	0.000	0.569	0.431
O61.8 Other failed induction of labour	0.000	0.569	0.431
O61.1 Failed instrumental induction of labour	0.000	0.569	0.431
O62.0 Primary inadequate contractions	0.000	0.581	0.419
O60.3 Preterm delivery without spontaneous labour	0.000	0.596	0.403
O60.2 Preterm spontaneous labour with term delivery	0.000	0.596	0.403
O60.1 Preterm spontaneous labour with preterm delivery	0.000	0.596	0.403
O60.0 Preterm labour without delivery	0.000	0.596	0.403
O65.9 Obstructed labour due to maternal pelvic abnormality, unspecified	0.000	0.596	0.403
O65.8 Obstructed labour due to other maternal pelvic abnormalities	0.000	0.596	0.403
O65.5 Obstructed labour due to abnormality of maternal pelvic organs	0.000	0.596	0.403
O65.4 Obstructed labour due to foetopelvic disproportion, unspecified	0.000	0.596	0.403
O65.3 Obstructed labour due to pelvic outlet and midcavity contraction	0.000	0.596	0.403
O65.2 Obstructed labour due to pelvic inlet contraction	0.000	0.596	0.403
O65.1 Obstructed labour due to generally contracted pelvis	0.000	0.596	0.403
O65.0 Obstructed labour due to deformed pelvis	0.000	0.596	0.403
O74.9 Complication of anaesthesia during labour and delivery, unspecified	0.000	0.596	0.403
O74.8 Other complications of anaesthesia during labour and delivery	0.000	0.596	0.403
O74.7 Failed or difficult intubation during labour and delivery	0.000	0.596	0.403
O74.6 Other complications of spinal and epidural anaesthesia during labour and delivery	0.000	0.596	0.403
O74.5 Spinal and epidural anaesthesia-induced headache during labour and delivery	0.000	0.596	0.403
O74.4 Toxic reaction to local anaesthesia during labour and delivery	0.000	0.596	0.403
O74.3 Central nervous system complications of anaesthesia during labour and delivery	0.000	0.596	0.403
O74.2 Cardiac complications of anaesthesia during labour and delivery	0.000	0.596	0.403
O74.1 Other pulmonary complications of anaesthesia during labour and delivery	0.000	0.596	0.403
O74.0 Aspiration pneumonitis due to anaesthesia during labour and delivery	0.000	0.596	0.403
O75.6 Delayed delivery after spontaneous or unspecified rupture of membranes	0.000	0.599	0.401
O68.2 Labour and delivery complicated by foetal heart rate anomaly with meconium in amniotic fluid	0.000	0.604	0.396
O69.8 Labour and delivery complicated by other cord complications	0.000	0.606	0.393
O75.0 Maternal distress during labour and delivery	0.000	0.607	0.393
O73.0 Retained placenta, without haemorrhage	0.000	0.609	0.391
O66.9 Obstructed labour, unspecified	0.000	0.613	0.387
O66.8 Other specified obstructed labour	0.000	0.613	0.387
O66.4 Failed trial of labour, unspecified	0.000	0.613	0.387
O66.3 Obstructed labour due to other abnormalities of foetus	0.000	0.613	0.387
O66.2 Obstructed labour due to unusually large foetus	0.000	0.613	0.387
O66.1 Obstructed labour due to locked twins	0.000	0.613	0.387
O66.0 Obstructed labour due to shoulder dystocia	0.000	0.613	0.387
O68.3 Labour and delivery complicated by biochemical evidence of foetal stress	0.000	0.616	0.384
O68.9 Labour and delivery complicated by foetal stress, unspecified	0.000	0.634	0.366
O64.1 Obstructed labour due to breech presentation	0.000	0.635	0.365
O66.5 Failed application of vacuum extractor and forceps, unspecified	0.000	0.636	0.364
O71.9 Obstetric trauma, unspecified	0.000	0.642	0.358
O71.8 Other specified obstetric trauma	0.000	0.642	0.358
O71.7 Obstetric haematoma of pelvis	0.000	0.642	0.358
O71.6 Obstetric damage to pelvic joints and ligaments	0.000	0.642	0.358
O71.5 Other obstetric injury to pelvic organs	0.000	0.642	0.358
O71.3 Obstetric laceration of cervix	0.000	0.642	0.358
O71.2 Postpartum inversion of uterus	0.000	0.642	0.358
O71.1 Rupture of uterus during labour	0.000	0.642	0.358
O71.0 Rupture of uterus before onset of labour	0.000	0.642	0.358
O67.8 Other intrapartum haemorrhage	0.000	0.642	0.357
O67.0 Intrapartum haemorrhage with coagulation defect	0.000	0.642	0.357
O73.1 Retained portions of placenta and membranes, without haemorrhage	0.000	0.668	0.332
O68.1 Labour and delivery complicated by meconium in amniotic fluid	0.000	0.683	0.317
O68.8 Labour and delivery complicated by other evidence of foetal stress	0.000	0.696	0.304
O71.4 Obstetric high vaginal laceration alone	0.000	0.706	0.294
O67.9 Intrapartum haemorrhage, unspecified	0.000	0.707	0.293
I27 Other pulmonary heart diseases	0.291	0.709	0.000
I20-I25 Ischaemic heart diseases	0.290	0.710	0.000
I25 Chronic ischaemic heart disease	0.290	0.710	0.000
Chapter IX Diseases of the circulatory system	0.289	0.711	0.000
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation	0.289	0.711	0.000
I05-I09 Chronic rheumatic heart diseases	0.288	0.712	0.000
I25.2 Old myocardial infarction	0.286	0.714	0.000
I27.0 Primary pulmonary hypertension	0.284	0.716	0.000
I20 Angina pectoris	0.279	0.721	0.000
I20.8 Other forms of angina pectoris	0.273	0.727	0.000
I08 Multiple valve diseases	0.269	0.731	0.000
I25.9 Chronic ischaemic heart disease, unspecified	0.268	0.732	0.000
I60-I69 Cerebrovascular diseases	0.266	0.734	0.000
I05 Rheumatic mitral valve diseases	0.258	0.742	0.000
I27.2 Other secondary pulmonary hypertension	0.254	0.746	0.000
I07 Rheumatic tricuspid valve diseases	0.253	0.747	0.000
I63 Cerebral infarction	0.248	0.752	0.000
I27.9 Pulmonary heart disease, unspecified	0.244	0.756	0.000
I62 Other nontraumatic intracranial haemorrhage	0.234	0.766	0.000
I20.9 Angina pectoris, unspecified	0.233	0.767	0.000
I05.9 Mitral valve disease, unspecified	0.233	0.767	0.000
I08.3 Combined disorders of mitral, aortic and tricuspid valves	0.231	0.769	0.000
I25.8 Other forms of chronic ischaemic heart disease	0.230	0.770	0.000
I07.1 Tricuspid insufficiency	0.228	0.772	0.000
I65 Occlusion and stenosis of precerebral arteries, not resulting in cerebral infarction	0.223	0.777	0.000
I27.8 Other specified pulmonary heart diseases	0.222	0.777	0.000
I08.2 Disorders of both aortic and tricuspid valves	0.221	0.779	0.000
I08.8 Other multiple valve diseases	0.219	0.781	0.000
I26 Pulmonary embolism	0.212	0.788	0.000
I08.0 Disorders of both mitral and aortic valves	0.210	0.790	0.000
I27.1 Kyphoscoliotic heart disease	0.209	0.791	0.000
I23 Certain current complications following acute myocardial infarction	0.208	0.792	0.000
I25.6 Silent myocardial ischaemia	0.208	0.792	0.000
I25.4 Coronary artery aneurysm	0.208	0.792	0.000
I25.0 Atherosclerotic cardiovascular disease, so described	0.208	0.792	0.000
I69 Sequelae of cerebrovascular disease	0.208	0.792	0.000
I00-I02 Acute rheumatic fever	0.208	0.792	0.000
I28 Other diseases of pulmonary vessels	0.207	0.792	0.000
I63.9 Cerebral infarction, unspecified	0.207	0.793	0.000
I09 Other rheumatic heart diseases	0.206	0.793	0.000
I06 Rheumatic aortic valve diseases	0.206	0.793	0.000
I05.1 Rheumatic mitral insufficiency	0.205	0.795	0.000
I61 Intracerebral haemorrhage	0.202	0.798	0.000
I25.5 Ischaemic cardiomyopathy	0.201	0.799	0.000
I63.8 Other cerebral infarction	0.200	0.800	0.000
I63.5 Cerebral infarction due to unspecified occlusion or stenosis of cerebral arteries	0.199	0.801	0.000
I63.2 Cerebral infarction due to unspecified occlusion or stenosis of precerebral arteries	0.196	0.804	0.000
I62.0 Subdural haemorrhage (acute) (nontraumatic)	0.195	0.804	0.000
I62.9 Intracranial haemorrhage (nontraumatic), unspecified	0.194	0.806	0.000
I08.9 Multiple valve disease, unspecified	0.193	0.807	0.000
I68 Cerebrovascular disorders in diseases classified elsewhere	0.191	0.809	0.000
I66 Occlusion and stenosis of cerebral arteries, not resulting in cerebral infarction	0.191	0.809	0.000
I22 Subsequent myocardial infarction	0.190	0.810	0.000
I95-I99 Other and unspecified disorders of the circulatory system	0.190	0.810	0.000
I08.1 Disorders of both mitral and tricuspid valves	0.189	0.811	0.000
I05.2 Mitral stenosis with insufficiency	0.188	0.811	0.000
I25.1 Atherosclerotic heart disease	0.188	0.812	0.000
I63.3 Cerebral infarction due to thrombosis of cerebral arteries	0.188	0.812	0.000
I10-I15 Hypertensive diseases	0.187	0.813	0.000
I05.8 Other mitral valve diseases	0.185	0.815	0.000
I70-I79 Diseases of arteries, arterioles and capillaries	0.183	0.817	0.000
I07.9 Tricuspid valve disease, unspecified	0.181	0.819	0.000
I07.8 Other tricuspid valve diseases	0.181	0.819	0.000
I07.2 Tricuspid stenosis with insufficiency	0.181	0.819	0.000
I07.0 Tricuspid stenosis	0.181	0.819	0.000
I65.2 Occlusion and stenosis of carotid artery	0.179	0.821	0.000
I63.6 Cerebral infarction due to cerebral venous thrombosis, nonpyogenic	0.178	0.822	0.000
I63.1 Cerebral infarction due to embolism of precerebral arteries	0.178	0.822	0.000
I63.0 Cerebral infarction due to thrombosis of precerebral arteries	0.178	0.822	0.000
I65.0 Occlusion and stenosis of vertebral artery	0.178	0.822	0.000
I26.0 Pulmonary embolism with mention of acute cor pulmonale	0.178	0.822	0.000
I63.4 Cerebral infarction due to embolism of cerebral arteries	0.174	0.825	0.000
I69.8 Sequelae of other and unspecified cerebrovascular diseases	0.172	0.828	0.000
I24 Other acute ischaemic heart diseases	0.172	0.828	0.000
I05.0 Mitral stenosis	0.171	0.829	0.000
I69.4 Sequelae of stroke, not specified as haemorrhage or infarction	0.169	0.831	0.000
I62.1 Nontraumatic extradural haemorrhage	0.168	0.832	0.000
I12 Hypertensive renal disease	0.167	0.833	0.000
I61.8 Other intracerebral haemorrhage	0.163	0.837	0.000
I20.0 Unstable angina	0.163	0.837	0.000
I25.3 Aneurysm of heart	0.163	0.837	0.000
I20.1 Angina pectoris with documented spasm	0.160	0.839	0.000
I65.9 Occlusion and stenosis of unspecified precerebral artery	0.160	0.840	0.000
I65.8 Occlusion and stenosis of other precerebral artery	0.160	0.840	0.000
I65.3 Occlusion and stenosis of multiple and bilateral precerebral arteries	0.160	0.840	0.000
I65.1 Occlusion and stenosis of basilar artery	0.160	0.840	0.000
I60 Subarachnoid haemorrhage	0.159	0.841	0.000
I72 Other aneurysm	0.158	0.842	0.000
I22.0 Subsequent myocardial infarction of anterior wall	0.156	0.844	0.000
I98 Other disorders of circulatory system in diseases classified elsewhere	0.156	0.844	0.000
I61.4 Intracerebral haemorrhage in cerebellum	0.153	0.847	0.000
I71 Aortic aneurysm and dissection	0.153	0.847	0.000
I67 Other cerebrovascular diseases	0.151	0.849	0.000
I23.8 Other current complications following acute myocardial infarction	0.149	0.850	0.000
I23.6 Thrombosis of atrium, auricular appendage and ventricle as current complications following acute myocardial infarction	0.149	0.850	0.000
I23.5 Rupture of papillary muscle as current complication following acute myocardial infarction	0.149	0.850	0.000
I23.4 Rupture of chordae tendineae as current complication following acute myocardial infarction	0.149	0.850	0.000
I23.3 Rupture of cardiac wall without haemopericardium as current complication following acute myocardial infarction	0.149	0.850	0.000
I23.2 Ventricular septal defect as current complication following acute myocardial infarction	0.149	0.850	0.000
I23.1 Atrial septal defect as current complication following acute myocardial infarction	0.149	0.850	0.000
I23.0 Haemopericardium as current complication following acute myocardial infarction	0.149	0.850	0.000
I69.2 Sequelae of other nontraumatic intracranial haemorrhage	0.149	0.851	0.000
I02 Rheumatic chorea	0.149	0.851	0.000
I01 Rheumatic fever with heart involvement	0.149	0.851	0.000
I00 Rheumatic fever without mention of heart involvement	0.149	0.851	0.000
I12.0 Hypertensive renal disease with renal failure	0.149	0.851	0.000
I28.9 Disease of pulmonary vessels, unspecified	0.149	0.851	0.000
I28.8 Other specified diseases of pulmonary vessels	0.149	0.851	0.000
I28.1 Aneurysm of pulmonary artery	0.149	0.851	0.000
I28.0 Arteriovenous fistula of pulmonary vessels	0.149	0.851	0.000
I69.1 Sequelae of intracerebral haemorrhage	0.149	0.851	0.000
I61.1 Intracerebral haemorrhage in hemisphere, cortical	0.148	0.851	0.000
I06.9 Rheumatic aortic valve disease, unspecified	0.148	0.852	0.000
I06.8 Other rheumatic aortic valve diseases	0.148	0.852	0.000
I06.2 Rheumatic aortic stenosis with insufficiency	0.148	0.852	0.000
I06.1 Rheumatic aortic insufficiency	0.148	0.852	0.000
I06.0 Rheumatic aortic stenosis	0.148	0.852	0.000
I09.9 Rheumatic heart disease, unspecified	0.148	0.852	0.000
I09.8 Other specified rheumatic heart diseases	0.148	0.852	0.000
I09.2 Chronic rheumatic pericarditis	0.148	0.852	0.000
I09.1 Rheumatic diseases of endocardium, valve unspecified	0.148	0.852	0.000
I09.0 Rheumatic myocarditis	0.148	0.852	0.000
Chapter XV Pregnancy, childbirth and the puerperium	0.000	0.852	0.148
I71.2 Thoracic aortic aneurysm, without mention of rupture	0.148	0.852	0.000
I61.6 Intracerebral haemorrhage, multiple localised	0.145	0.855	0.000
I61.5 Intracerebral haemorrhage, intraventricular	0.145	0.855	0.000
I61.3 Intracerebral haemorrhage in brain stem	0.145	0.855	0.000
I61.2 Intracerebral haemorrhage in hemisphere, unspecified	0.145	0.855	0.000
I61.0 Intracerebral haemorrhage in hemisphere, subcortical	0.145	0.855	0.000
I74 Arterial embolism and thrombosis	0.145	0.855	0.000
I99 Other and unspecified disorders of circulatory system	0.143	0.857	0.000
I69.0 Sequelae of subarachnoid haemorrhage	0.141	0.858	0.000
I72.4 Aneurysm of artery of lower extremity	0.141	0.859	0.000
I66.9 Occlusion and stenosis of unspecified cerebral artery	0.137	0.863	0.000
I66.8 Occlusion and stenosis of other cerebral artery	0.137	0.863	0.000
I66.4 Occlusion and stenosis of multiple and bilateral cerebral arteries	0.137	0.863	0.000
I66.3 Occlusion and stenosis of cerebellar arteries	0.137	0.863	0.000
I66.2 Occlusion and stenosis of posterior cerebral artery	0.137	0.863	0.000
I66.1 Occlusion and stenosis of anterior cerebral artery	0.137	0.863	0.000
I66.0 Occlusion and stenosis of middle cerebral artery	0.137	0.863	0.000
I68.8 Other cerebrovascular disorders in diseases classified elsewhere	0.137	0.863	0.000
I68.2 Cerebral arteritis in other diseases classified elsewhere	0.137	0.863	0.000
I68.1 Cerebral arteritis in infectious and parasitic diseases classified elsewhere	0.137	0.863	0.000
I68.0 Cerebral amyloid angiopathy	0.137	0.863	0.000
O94-O99 Other obstetric conditions, not elsewhere classified	0.000	0.864	0.136
I13 Hypertensive heart and renal disease	0.134	0.866	0.000
I74.2 Embolism and thrombosis of arteries of the upper extremities	0.132	0.868	0.000
I67.9 Cerebrovascular disease, unspecified	0.132	0.868	0.000
I12.9 Hypertensive renal disease without renal failure	0.132	0.868	0.000
I98.2 Oesophageal varices in diseases classified elsewhere	0.132	0.868	0.000
I11 Hypertensive heart disease	0.131	0.869	0.000
I97 Postprocedural disorders of circulatory system, not elsewhere classified	0.130	0.870	0.000
I24.0 Coronary thrombosis not resulting in myocardial infarction	0.129	0.871	0.000
I72.9 Aneurysm of unspecified site	0.129	0.871	0.000
I22.8 Subsequent myocardial infarction of other sites	0.128	0.871	0.000
O99 Other maternal diseases classifiable elsewhere but complicating pregnancy, childbirth and the puerperium	0.000	0.873	0.127
I60.2 Subarachnoid haemorrhage from anterior communicating artery	0.126	0.874	0.000
I15 Secondary hypertension	0.125	0.875	0.000
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere	0.124	0.876	0.000
I24.1 Dressler's syndrome	0.123	0.877	0.000
I78 Diseases of capillaries	0.122	0.878	0.000
I61.9 Intracerebral haemorrhage, unspecified	0.120	0.880	0.000
I70 Atherosclerosis	0.120	0.880	0.000
I72.0 Aneurysm of carotid artery	0.118	0.882	0.000
I22.1 Subsequent myocardial infarction of inferior wall	0.118	0.882	0.000
I69.3 Sequelae of cerebral infarction	0.118	0.882	0.000
I22.9 Subsequent myocardial infarction of unspecified site	0.117	0.883	0.000
O99.0 Anaemia complicating pregnancy, childbirth and the puerperium	0.000	0.885	0.115
I60.7 Subarachnoid haemorrhage from intracranial artery, unspecified	0.114	0.886	0.000
I60.6 Subarachnoid haemorrhage from other intracranial arteries	0.114	0.886	0.000
I60.5 Subarachnoid haemorrhage from vertebral artery	0.114	0.886	0.000
I60.4 Subarachnoid haemorrhage from basilar artery	0.114	0.886	0.000
I60.3 Subarachnoid haemorrhage from posterior communicating artery	0.114	0.886	0.000
I60.1 Subarachnoid haemorrhage from middle cerebral artery	0.114	0.886	0.000
I60.0 Subarachnoid haemorrhage from carotid siphon and bifurcation	0.114	0.886	0.000
I26.9 Pulmonary embolism without mention of acute cor pulmonale	0.114	0.886	0.000
O10-O16 Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium	0.000	0.886	0.114
I72.6 Aneurysm and dissection of vertebral artery	0.114	0.886	0.000
I72.5 Aneurysm and dissection of other precerebral arteries	0.114	0.886	0.000
I72.2 Aneurysm of renal artery	0.114	0.886	0.000
I72.1 Aneurysm of artery of upper extremity	0.114	0.886	0.000
I98.8 Other specified disorders of circulatory system in diseases classified elsewhere	0.112	0.888	0.000
I98.3 Oesophageal varices with bleeding in diseases classified elsewhere	0.112	0.888	0.000
I98.1 Cardiovascular disorders in other infectious and parasitic diseases classified elsewhere	0.112	0.888	0.000
I98.0 Cardiovascular syphilis	0.112	0.888	0.000
I71.8 Aortic aneurysm of unspecified site, ruptured	0.110	0.890	0.000
I71.6 Thoracoabdominal aortic aneurysm, without mention of rupture	0.110	0.890	0.000
I71.5 Thoracoabdominal aortic aneurysm, ruptured	0.110	0.890	0.000
I71.3 Abdominal aortic aneurysm, ruptured	0.110	0.890	0.000
I71.1 Thoracic aortic aneurysm, ruptured	0.110	0.890	0.000
I67.7 Cerebral arteritis, not elsewhere classified	0.109	0.891	0.000
I67.6 Nonpyogenic thrombosis of intracranial venous system	0.109	0.891	0.000
I67.5 Moyamoya disease	0.109	0.891	0.000
I67.4 Hypertensive encephalopathy	0.109	0.891	0.000
I67.3 Progressive vascular leukoencephalopathy	0.109	0.891	0.000
I67.0 Dissection of cerebral arteries, nonruptured	0.108	0.891	0.000
I60.8 Other subarachnoid haemorrhage	0.108	0.892	0.000
I01.9 Acute rheumatic heart disease, unspecified	0.107	0.893	0.000
I01.8 Other acute rheumatic heart disease	0.107	0.893	0.000
I01.2 Acute rheumatic myocarditis	0.107	0.893	0.000
I01.1 Acute rheumatic endocarditis	0.107	0.893	0.000
I01.0 Acute rheumatic pericarditis	0.107	0.893	0.000
I02.9 Rheumatic chorea without heart involvement	0.107	0.893	0.000
I02.0 Rheumatic chorea with heart involvement	0.107	0.893	0.000
I72.3 Aneurysm of iliac artery	0.105	0.895	0.000
I24.9 Acute ischaemic heart disease, unspecified	0.104	0.895	0.000
I74.9 Embolism and thrombosis of unspecified artery	0.104	0.896	0.000
I74.8 Embolism and thrombosis of other arteries	0.104	0.896	0.000
I74.4 Embolism and thrombosis of arteries of extremities, unspecified	0.104	0.896	0.000
I74.1 Embolism and thrombosis of other and unspecified parts of aorta	0.104	0.896	0.000
I74.0 Embolism and thrombosis of abdominal aorta	0.104	0.896	0.000
I71.0 Dissection of aorta [any part]	0.102	0.897	0.000
I24.8 Other forms of acute ischaemic heart disease	0.102	0.898	0.000
O85-O92 Complications predominantly related to the puerperium	0.000	0.898	0.102
I67.2 Cerebral atherosclerosis	0.102	0.898	0.000
O13 Gestational [pregnancy-induced] hypertension without significant proteinuria	0.000	0.900	0.100
O99.8 Other specified diseases and conditions complicating pregnancy, childbirth and the puerperium	0.000	0.900	0.100
I21 Acute myocardial infarction	0.100	0.900	0.000
O99.2 Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium	0.000	0.902	0.098
O98 Maternal infectious and parasitic diseases classifiable elsewhere but complicating pregnancy, childbirth and the puerperium	0.000	0.902	0.098
O97 Death from sequelae of direct obstetric causes	0.000	0.902	0.098
O96 Death from any obstetric cause occurring more than 42 days but less than one year after delivery	0.000	0.902	0.098
O95 Obstetric death of unspecified cause	0.000	0.902	0.098
O94 Sequelae of complication of pregnancy, childbirth and the puerperium	0.000	0.902	0.098
O99.6 Diseases of the digestive system complicating pregnancy, childbirth and the puerperium	0.000	0.903	0.097
I74.5 Embolism and thrombosis of iliac artery	0.097	0.903	0.000
I13.9 Hypertensive heart and renal disease, unspecified	0.096	0.904	0.000
I13.2 Hypertensive heart and renal disease with both (congestive) heart failure and renal failure	0.096	0.904	0.000
I13.1 Hypertensive heart and renal disease with renal failure	0.096	0.904	0.000
I13.0 Hypertensive heart and renal disease with (congestive) heart failure	0.096	0.904	0.000
O16 Unspecified maternal hypertension	0.000	0.904	0.096
I97.8 Other postprocedural disorders of circulatory system, not elsewhere classified	0.095	0.905	0.000
I72.8 Aneurysm of other specified arteries	0.094	0.906	0.000
I11.0 Hypertensive heart disease with (congestive) heart failure	0.094	0.906	0.000
I97.9 Postprocedural disorder of circulatory system, unspecified	0.093	0.906	0.000
I97.0 Postcardiotomy syndrome	0.093	0.906	0.000
I71.9 Aortic aneurysm of unspecified site, without mention of rupture	0.092	0.908	0.000
O99.7 Diseases of the skin and subcutaneous tissue complicating pregnancy, childbirth and the puerperium	0.000	0.908	0.091
O99.5 Diseases of the respiratory system complicating pregnancy, childbirth and the puerperium	0.000	0.908	0.091
O99.4 Diseases of the circulatory system complicating pregnancy, childbirth and the puerperium	0.000	0.908	0.091
O99.3 Mental disorders and diseases of the nervous system complicating pregnancy, childbirth and the puerperium	0.000	0.908	0.091
O99.1 Other diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism complicating pregnancy, childbirth and the puerperium	0.000	0.908	0.091
I97.2 Postmastectomy lymphoedema syndrome	0.091	0.909	0.000
I11.9 Hypertensive heart disease without (congestive) heart failure	0.091	0.909	0.000
I15.9 Seconday hypertension, unspecified	0.090	0.910	0.000
I15.8 Other secondary hypertension	0.090	0.910	0.000
I15.2 Hypertension secondary to endocrine disorders	0.090	0.910	0.000
I15.0 Renovascular hypertension	0.090	0.910	0.000
I73 Other peripheral vascular diseases	0.090	0.910	0.000
I79.8 Other disorders of arteries, arterioles and capillaries in diseases classified elsewhere	0.089	0.910	0.000
I79.1 Aortitis in diseases classified elsewhere	0.089	0.910	0.000
I79.0 Aneurysm of aorta in diseases classified elsewhere	0.089	0.910	0.000
I97.1 Other functional disturbances following cardiac surgery	0.089	0.911	0.000
I21.9 Acute myocardial infarction, unspecified	0.088	0.912	0.000
I78.0 Hereditary haemorrhagic telangiectasia	0.087	0.912	0.000
I78.9 Disease of capillaries, unspecified	0.087	0.912	0.000
I78.8 Other diseases of capillaries	0.087	0.912	0.000
I80-I89 Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified	0.087	0.913	0.000
I70.9 Generalised and unspecified atherosclerosis	0.086	0.914	0.000
I70.8 Atherosclerosis of other arteries	0.086	0.914	0.000
I70.1 Atherosclerosis of renal artery	0.086	0.914	0.000
Z92.1 Personal history of long-term (current) use of anticoagulants	0.086	0.914	0.000
I67.1 Cerebral aneurysm, nonruptured	0.085	0.914	0.000
O80-O84 Delivery	0.000	0.916	0.084
O20-O29 Other maternal disorders predominantly related to pregnancy	0.000	0.917	0.083
I79.2 Peripheral angiopathy in diseases classified elsewhere	0.082	0.918	0.000
O15 Eclampsia	0.000	0.918	0.082
O10 Pre-existing hypertension complicating pregnancy, childbirth and the puerperium	0.000	0.918	0.082
O11 Pre-existing hypertensive disorder with superimposed proteinuria	0.000	0.918	0.082
I70.0 Atherosclerosis of aorta	0.081	0.918	0.000
I15.1 Hypertension secondary to other renal disorders	0.080	0.919	0.000
I70.2 Atherosclerosis of arteries of the extremities	0.080	0.919	0.000
I64 Stroke, not specified as haemorrhage or infarction	0.080	0.920	0.000
I78.1 Naevus, nonneoplastic	0.077	0.922	0.000
O90 Complications of the puerperium, not elsewhere classified	0.000	0.922	0.077
I95 Hypotension	0.075	0.925	0.000
I82 Other venous embolism and thrombosis	0.073	0.927	0.000
O92 Other disorders of breast and lactation associated with childbirth	0.000	0.927	0.073
O91 Infections of breast associated with childbirth	0.000	0.927	0.073
O89 Complications of anaesthesia during the puerperium	0.000	0.927	0.073
O88 Obstetric embolism	0.000	0.927	0.073
O87 Venous complications in the puerperium	0.000	0.927	0.073
O00-O08 Pregnancy with abortive outcome	0.000	0.928	0.072
I21.X Presumed acute myicardial infaction (unconfirmed)	0.072	0.928	0.000
I21.3 Acute transmural myocardial infarction of unspecified site	0.072	0.928	0.000
O86 Other puerperal infections	0.000	0.929	0.071
O96.9 Death from unspecified obstetric cause	0.000	0.930	0.070
O96.1 Death from indirect obstetric cause	0.000	0.930	0.070
O96.0 Death from direct obstetric cause	0.000	0.930	0.070
O97.9 Death from sequelae of obstetric cause, unspecified	0.000	0.930	0.070
O97.1 Death from sequelae of indirect obstetric cause	0.000	0.930	0.070
O97.0 Death from sequelae of direct obstetric cause	0.000	0.930	0.070
O98.9 Unspecified maternal infectious or parasitic disease complicating pregnancy, childbirth and the puerperium	0.000	0.930	0.070
O98.8 Other maternal infectious and parasitic diseases complicating pregnancy, childbirth and the puerperium	0.000	0.930	0.070
O98.7 Human immunodeficiency [HIV] disease complicating pregnancy, childbirth and the puerperium	0.000	0.930	0.070
O98.6 Protozoal diseases complicating pregnancy, childbirth and the puerperium	0.000	0.930	0.070
O98.5 Other viral diseases complicating pregnancy, childbirth and the puerperium	0.000	0.930	0.070
O98.4 Viral hepatitis complicating pregnancy, childbirth and the puerperium	0.000	0.930	0.070
O98.3 Other infections with a predominantly sexual mode of transmission complicating pregnancy, childbirth and the puerperium	0.000	0.930	0.070
O98.2 Gonorrhoea complicating pregnancy, childbirth and the puerperium	0.000	0.930	0.070
O98.1 Syphilis complicating pregnancy, childbirth and the puerperium	0.000	0.930	0.070
O98.0 Tuberculosis complicating pregnancy, childbirth and the puerperium	0.000	0.930	0.070
I73.8 Other specified peripheral vascular diseases	0.070	0.930	0.000
I81 Portal vein thrombosis	0.069	0.931	0.000
I74.3 Embolism and thrombosis of arteries of the lower extremities	0.069	0.931	0.000
I60.9 Subarachnoid haemorrhage, unspecified	0.067	0.933	0.000
O23 Infections of genito-urinary tract in pregnancy	0.000	0.935	0.065
O85 Puerperal sepsis	0.000	0.935	0.064
I73.1 Thromboangiitis obliterans [Buerger]	0.064	0.936	0.000
O81 Single delivery by forceps and vacuum extractor	0.000	0.936	0.064
I85 Oesophageal varices	0.064	0.936	0.000
I95.2 Hypotension due to drugs	0.063	0.937	0.000
I77 Other disorders of arteries and arterioles	0.063	0.937	0.000
I88 Nonspecific lymphadenitis	0.062	0.937	0.000
I70.11 Atherosclerosis of renal artery (with gangrene)	0.062	0.938	0.000
I70.10 Atherosclerosis of renal artery (without gangrene)	0.062	0.938	0.000
I70.81 Atherosclerosis of other arteries (with gangrene)	0.062	0.938	0.000
I70.80 Atherosclerosis of other arteries (without gangrene)	0.062	0.938	0.000
I70.91 Generalized and unspecified atherosclerosis (with gangrene)	0.062	0.938	0.000
I70.90 Generalized and unspecified atherosclerosis (without gangrene)	0.062	0.938	0.000
I83 Varicose veins of lower extremities	0.062	0.938	0.000
O84 Multiple delivery	0.000	0.940	0.060
O83 Other assisted single delivery	0.000	0.940	0.060
O24 Diabetes mellitus in pregnancy	0.000	0.940	0.060
O90.8 Other complications of the puerperium, not elsewhere classified	0.000	0.940	0.060
I82.9 Embolism and thrombosis of unspecified vein	0.060	0.940	0.000
I89 Other non-infective disorders of lymphatic vessels and lymph nodes	0.060	0.940	0.000
O12 Gestational [pregnancy-induced] oedema and proteinuria without hypertension	0.000	0.940	0.059
O29 Complications of anaesthesia during pregnancy	0.000	0.940	0.060
O28 Abnormal findings on antenatal screening of mother	0.000	0.940	0.060
O22 Venous complications in pregnancy	0.000	0.940	0.060
O25 Malnutrition in pregnancy	0.000	0.940	0.060
I21.2 Acute transmural myocardial infarction of other sites	0.059	0.941	0.000
O10.9 Unspecified pre-existing hypertension complicating pregnancy, childbirth and the puerperium	0.000	0.941	0.059
O10.4 Pre-existing secondary hypertension complicating pregnancy, childbirth and the puerperium	0.000	0.941	0.059
O10.3 Pre-existing hypertensive heart and renal disease complicating pregnancy, childbirth and the puerperium	0.000	0.941	0.059
O10.2 Pre-existing hypertensive renal disease complicating pregnancy, childbirth and the puerperium	0.000	0.941	0.059
O10.1 Pre-existing hypertensive heart disease complicating pregnancy, childbirth and the puerperium	0.000	0.941	0.059
O10.0 Pre-existing essential hypertension complicating pregnancy, childbirth and the puerperium	0.000	0.941	0.059
O15.9 Eclampsia, unspecified as to time period	0.000	0.941	0.059
O15.2 Eclampsia in the puerperium	0.000	0.941	0.059
O15.1 Eclampsia in labour	0.000	0.941	0.059
O15.0 Eclampsia in pregnancy	0.000	0.941	0.059
O26 Maternal care for other conditions predominantly related to pregnancy	0.000	0.941	0.059
I70.01 Atherosclerosis of aorta (with gangrene)	0.059	0.941	0.000
I21.0 Acute transmural myocardial infarction of anterior wall	0.058	0.942	0.000
I70.21 Atherosclerosis of arteries of extremities (with gangrene)	0.058	0.942	0.000
I73.0 Raynaud's syndrome	0.058	0.942	0.000
O14 Gestational [pregnancy-induced] hypertension with significant proteinuria	0.000	0.943	0.057
O00 Ectopic pregnancy	0.000	0.943	0.057
O90.9 Complication of the puerperium, unspecified	0.000	0.944	0.056
O90.5 Postpartum thyroiditis	0.000	0.944	0.056
O90.4 Postpartum acute renal failure	0.000	0.944	0.056
O90.3 Cardiomyopathy in the puerperium	0.000	0.944	0.056
O90.2 Haematoma of obstetric wound	0.000	0.944	0.056
O90.1 Disruption of perineal obstetric wound	0.000	0.944	0.056
O90.0 Disruption of Caesarean section wound	0.000	0.944	0.056
I82.2 Embolism and thrombosis of vena cava	0.055	0.944	0.000
I82.8 Embolism and thrombosis of other specified veins	0.055	0.945	0.000
I71.4 Abdominal aortic aneurysm, without mention of rupture	0.055	0.945	0.000
I87 Other disorders of veins	0.055	0.945	0.000
I86 Varicose veins of other sites	0.054	0.946	0.000
I70.00 Atherosclerosis of aorta (without gangrene)	0.054	0.946	0.000
I95.8 Other hypotension	0.054	0.946	0.000
I95.0 Idiopathic hypotension	0.054	0.946	0.000
O23.4 Unspecified infection of urinary tract in pregnancy	0.000	0.947	0.053
I83.1 Varicose veins of lower extremities with inflammation	0.053	0.947	0.000
I82.3 Embolism and thrombosis of renal vein	0.053	0.947	0.000
I82.1 Thrombophlebitis migrans	0.053	0.947	0.000
I82.0 Budd-Chiari syndrome	0.053	0.947	0.000
O87.9 Venous complication in the puerperium, unspecified	0.000	0.947	0.052
O87.8 Other venous complications in the puerperium	0.000	0.947	0.052
O87.3 Cerebral venous thrombosis in the puerperium	0.000	0.947	0.052
O87.2 Haemorrhoids in the puerperium	0.000	0.947	0.052
O87.1 Deep phlebothrombosis in the puerperium	0.000	0.947	0.052
O87.0 Superficial thrombophlebitis in the puerperium	0.000	0.947	0.052
O88.8 Other obstetric embolism	0.000	0.947	0.052
O88.3 Obstetric pyaemic and septic embolism	0.000	0.947	0.052
O88.2 Obstetric blood-clot embolism	0.000	0.947	0.052
O88.1 Amniotic fluid embolism	0.000	0.947	0.052
O88.0 Obstetric air embolism	0.000	0.947	0.052
O89.9 Complication of anaesthesia during the puerperium, unspecified	0.000	0.947	0.052

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations