TreeWAS – Variant ID: rs12196597

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
K90.0 Coeliac disease	0.000	0.000	1.000
L40.9 Psoriasis, unspecified	1.000	0.000	0.000
L40.5 Arthropathic psoriasis	1.000	0.000	0.000
L40 Psoriasis	1.000	0.000	0.000
L40.8 Other psoriasis	0.849	0.151	0.000
L40.0 Psoriasis vulgaris	0.842	0.158	0.000
E10.9 Without complications	0.000	0.189	0.811
E10 Insulin-dependent diabetes mellitus	0.000	0.192	0.808
E10.3 With ophthalmic complications	0.000	0.212	0.788
K90 Intestinal malabsorption	0.000	0.227	0.773
J47 Bronchiectasis	0.000	0.242	0.758
J45.9 Asthma, unspecified	0.000	0.254	0.746
J45 Asthma	0.000	0.265	0.735
J40-J47 Chronic lower respiratory diseases	0.000	0.271	0.729
E05 Thyrotoxicosis [hyperthyroidism]	0.000	0.273	0.727
E05.9 Thyrotoxicosis, unspecified	0.000	0.275	0.725
K90.9 Intestinal malabsorption, unspecified	0.000	0.279	0.721
E00-E07 Disorders of thyroid gland	0.000	0.280	0.720
L40.4 Guttate psoriasis	0.717	0.283	0.000
L40.3 Pustulosis palmaris et plantaris	0.717	0.283	0.000
L40.2 Acrodermatitis continua	0.717	0.283	0.000
L40.1 Generalised pustular psoriasis	0.717	0.283	0.000
E10-E14 Diabetes mellitus	0.000	0.293	0.707
E10.1 With ketoacidosis	0.000	0.297	0.703
E05.0 Thyrotoxicosis with diffuse goitre	0.000	0.299	0.701
Chapter IV Endocrine, nutritional and metabolic diseases	0.000	0.301	0.699
E03 Other hypothyroidism	0.000	0.304	0.696
E03.9 Hypothyroidism, unspecified	0.000	0.315	0.685
E10.4 With neurological complications	0.000	0.349	0.651
E10.0 With coma	0.000	0.388	0.612
E10.5 With peripheral circulatory complications	0.000	0.396	0.604
E40-E46 Malnutrition	0.000	0.405	0.595
E10.7 With multiple complications	0.000	0.421	0.579
E10.6 With other specified complications	0.000	0.421	0.579
K90.4 Malabsorption due to intolerance, not elsewhere classified	0.000	0.430	0.570
J42 Unspecified chronic bronchitis	0.000	0.433	0.567
E10.8 With unspecified complications	0.000	0.443	0.557
K90.8 Other intestinal malabsorption	0.000	0.445	0.555
K90.3 Pancreatic steatorrhoea	0.000	0.445	0.555
K90.2 Blind loop syndrome, not elsewhere classified	0.000	0.445	0.555
K90.1 Tropical sprue	0.000	0.445	0.555
E07 Other disorders of thyroid	0.000	0.446	0.554
E65-E68 Obesity and other hyperalimentation	0.000	0.452	0.548
J43 Emphysema	0.000	0.468	0.532
J45.8 Mixed asthma	0.000	0.473	0.527
J45.1 Nonallergic asthma	0.000	0.473	0.527
J41 Simple and mucopurulent chronic bronchitis	0.000	0.477	0.523
E05.8 Other thyrotoxicosis	0.000	0.479	0.521
E05.5 Thyroid crisis or storm	0.000	0.479	0.521
E05.4 Thyrotoxicosis factitia	0.000	0.479	0.521
E05.3 Thyrotoxicosis from ectopic thyroid tissue	0.000	0.479	0.521
E05.1 Thyrotoxicosis with toxic single thyroid nodule	0.000	0.479	0.521
E46 Unspecified protein-energy malnutrition	0.000	0.480	0.520
L40-L45 Papulosquamous disorders	0.519	0.481	0.000
E01 Iodine-deficiency-related thyroid disorders and allied conditions	0.000	0.484	0.516
E00 Congenital iodine-deficiency syndrome	0.000	0.484	0.516
E02 Subclinical iodine-deficiency hypothyroidism	0.000	0.484	0.516
E03.8 Other specified hypothyroidism	0.000	0.488	0.512
J46 Status asthmaticus	0.000	0.491	0.509
E12 Malnutrition-related diabetes mellitus	0.000	0.493	0.507
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion	0.000	0.496	0.504
E03.5 Myxoedema coma	0.000	0.501	0.499
E03.4 Atrophy of thyroid (acquired)	0.000	0.501	0.499
E03.3 Postinfectious hypothyroidism	0.000	0.501	0.499
E03.1 Congenital hypothyroidism without goitre	0.000	0.501	0.499
E03.0 Congenital hypothyroidism with diffuse goitre	0.000	0.501	0.499
J45.0 Predominantly allergic asthma	0.000	0.528	0.472
E10.2 With renal complications	0.000	0.534	0.466
E65 Localised adiposity	0.000	0.535	0.465
E07.9 Disorder of thyroid, unspecified	0.000	0.544	0.456
E13 Other specified diabetes mellitus	0.000	0.570	0.430
E50-E64 Other nutritional deficiencies	0.000	0.571	0.429
E44 Protein-energy malnutrition of moderate and mild degree	0.000	0.573	0.426
E45 Retarded development following protein-energy malnutrition	0.000	0.573	0.426
E43 Unspecified severe protein-energy malnutrition	0.000	0.573	0.426
E42 Marasmic kwashiorkor	0.000	0.573	0.426
E41 Nutritional marasmus	0.000	0.573	0.426
E40 Kwashiorkor	0.000	0.573	0.426
L43 Lichen planus	0.415	0.585	0.000
J43.9 Emphysema, unspecified	0.000	0.587	0.413
E06 Thyroiditis	0.000	0.595	0.405
E07.1 Dyshormogenetic goitre	0.000	0.603	0.397
E07.0 Hypersecretion of calcitonin	0.000	0.603	0.397
E67 Other hyperalimentation	0.000	0.607	0.393
E68 Sequelae of hyperalimentation	0.000	0.607	0.393
E05.2 Thyrotoxicosis with toxic multinodular goitre	0.000	0.610	0.390
E03.2 Hypothyroidism due to medicaments and other exogenous substances	0.000	0.610	0.389
E14 Unspecified diabetes mellitus	0.000	0.611	0.389
J43.8 Other emphysema	0.000	0.619	0.381
J43.1 Panlobular emphysema	0.000	0.619	0.381
J43.0 MacLeod's syndrome	0.000	0.619	0.381
J41.8 Mixed simple and mucopurulent chronic bronchitis	0.000	0.625	0.375
J41.1 Mucopurulent chronic bronchitis	0.000	0.625	0.375
J41.0 Simple chronic bronchitis	0.000	0.625	0.375
L44 Other papulosquamous disorders	0.372	0.628	0.000
L41 Parapsoriasis	0.372	0.628	0.000
L45 Papulosquamous disorders in diseases classified elsewhere	0.372	0.628	0.000
L42 Pityriasis rosea	0.372	0.628	0.000
E00.9 Congenital iodine-deficiency syndrome, unspecified	0.000	0.630	0.370
E00.2 Congenital iodine-deficiency syndrome, mixed type	0.000	0.630	0.370
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type	0.000	0.630	0.370
E00.0 Congenital iodine-deficiency syndrome, neurological type	0.000	0.630	0.370
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions	0.000	0.630	0.370
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified	0.000	0.630	0.370
E01.1 Iodine-deficiency-related multinodular (endemic) goitre	0.000	0.630	0.370
E01.0 Iodine-deficiency-related diffuse (endemic) goitre	0.000	0.630	0.370
E12.9 Without complications	0.000	0.636	0.364
E12.8 With unspecified complications	0.000	0.636	0.364
E12.7 With multiple complications	0.000	0.636	0.364
E12.6 With other specified complications	0.000	0.636	0.364
E12.5 With peripheral circulatory complications	0.000	0.636	0.364
E12.4 With neurological complications	0.000	0.636	0.364
E12.3 With ophthalmic complications	0.000	0.636	0.364
E12.2 With renal complications	0.000	0.636	0.364
E12.1 With ketoacidosis	0.000	0.636	0.364
E12.0 With coma	0.000	0.636	0.364
E16 Other disorders of pancreatic internal secretion	0.000	0.636	0.364
E07.8 Other specified disorders of thyroid	0.000	0.637	0.363
E15 Nondiabetic hypoglycaemic coma	0.000	0.638	0.361
L43.9 Lichen planus, unspecified	0.355	0.645	0.000
J43.2 Centrilobular emphysema	0.000	0.648	0.351
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs	0.350	0.650	0.000
E66 Obesity	0.000	0.656	0.344
E20-E35 Disorders of other endocrine glands	0.000	0.660	0.340
T42.4 Benzodiazepines	0.339	0.661	0.000
T42.6 Other antiepileptic and sedative-hypnotic drugs	0.338	0.662	0.000
T36-T50 Poisoning by drugs, medicaments and biological substances	0.337	0.663	0.000
E04 Other non-toxic goitre	0.000	0.672	0.328
J40 Bronchitis, not specified as acute or chronic	0.000	0.675	0.325
T43 Poisoning by psychotropic drugs, not elsewhere classified	0.324	0.676	0.000
E66.8 Other obesity	0.000	0.682	0.318
E14.3 With ophthalmic complications	0.000	0.683	0.317
E21 Hyperparathyroidism and other disorders of parathyroid gland	0.000	0.684	0.316
E55 Vitamin D deficiency	0.000	0.685	0.315
E13.8 With unspecified complications	0.000	0.692	0.308
E13.7 With multiple complications	0.000	0.692	0.308
E13.6 With other specified complications	0.000	0.692	0.308
E13.5 With peripheral circulatory complications	0.000	0.692	0.308
E13.4 With neurological complications	0.000	0.692	0.308
E13.3 With ophthalmic complications	0.000	0.692	0.308
E13.2 With renal complications	0.000	0.692	0.308
E13.1 With ketoacidosis	0.000	0.692	0.308
E13.0 With coma	0.000	0.692	0.308
E64 Sequelae of malnutrition and other nutritional deficiencies	0.000	0.692	0.308
E63 Other nutritional deficiencies	0.000	0.692	0.308
E56 Other vitamin deficiencies	0.000	0.692	0.308
E51 Thiamine deficiency	0.000	0.692	0.308
E50 Vitamin A deficiency	0.000	0.692	0.308
E60 Dietary zinc deficiency	0.000	0.692	0.308
E59 Dietary selenium deficiency	0.000	0.692	0.308
E58 Dietary calcium deficiency	0.000	0.692	0.308
E54 Ascorbic acid deficiency	0.000	0.692	0.308
E52 Niacin deficiency [pellagra]	0.000	0.692	0.308
E44.1 Mild protein-energy malnutrition	0.000	0.694	0.306
E44.0 Moderate protein-energy malnutrition	0.000	0.694	0.306
T43.3 Phenothiazine antipsychotics and neuroleptics	0.302	0.698	0.000
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified	0.299	0.701	0.000
L43.3 Subacute (active) lichen planus	0.298	0.702	0.000
L43.2 Lichenoid drug reaction	0.298	0.702	0.000
L43.1 Bullous lichen planus	0.298	0.702	0.000
L43.0 Hypertrophic lichen planus	0.298	0.702	0.000
E06.5 Other chronic thyroiditis	0.000	0.709	0.290
E06.4 Drug-induced thyroiditis	0.000	0.709	0.290
E06.2 Chronic thyroiditis with transient thyrotoxicosis	0.000	0.709	0.290
E06.1 Subacute thyroiditis	0.000	0.709	0.290
E06.0 Acute thyroiditis	0.000	0.709	0.290
E21.3 Hyperparathyroidism, unspecified	0.000	0.712	0.288
T42.1 Iminostilbenes	0.283	0.717	0.000
E16.2 Hypoglycaemia, unspecified	0.000	0.718	0.282
E67.8 Other specified hyperalimentation	0.000	0.718	0.282
E67.3 Hypervitaminosis D	0.000	0.718	0.282
E67.2 Megavitamin-B6 syndrome	0.000	0.718	0.282
E67.1 Hypercarotenaemia	0.000	0.718	0.282
E67.0 Hypervitaminosis A	0.000	0.718	0.282
E14.8 With unspecified complications	0.000	0.721	0.279
E14.7 With multiple complications	0.000	0.721	0.279
E14.6 With other specified complications	0.000	0.721	0.279
E14.5 With peripheral circulatory complications	0.000	0.721	0.279
E14.4 With neurological complications	0.000	0.721	0.279
E14.2 Withrenal complications	0.000	0.721	0.279
E14.1 With ketoacidosis	0.000	0.721	0.279
E14.0 With coma	0.000	0.721	0.279
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified	0.279	0.721	0.000
T43.5 Other and unspecified antipsychotics and neuroleptics	0.277	0.723	0.000
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances	0.275	0.725	0.000
T42.7 Antiepileptic and sedative-hypnotic drugs, unspecified	0.274	0.726	0.000
E61 Deficiency of other nutrient elements	0.000	0.728	0.272
E53 Deficiency of other B group vitamins	0.000	0.730	0.270
L43.8 Other lichen planus	0.269	0.730	0.000
L41.9 Parapsoriasis, unspecified	0.267	0.733	0.000
L41.8 Other parapsoriasis	0.267	0.733	0.000
L41.5 Retiform parapsoriasis	0.267	0.733	0.000
L41.4 Large plaque parapsoriasis	0.267	0.733	0.000
L41.3 Small plaque parapsoriasis	0.267	0.733	0.000
L41.2 Lymphomatoid papulosis	0.267	0.733	0.000
L41.1 Pityriasis lichenoides chronica	0.267	0.733	0.000
L41.0 Pityriasis lichenoides et varioliformis acuta	0.267	0.733	0.000
L44.9 Papulosquamous disorder, unspecified	0.267	0.733	0.000
L44.8 Other specified papulosquamous disorders	0.267	0.733	0.000
L44.4 Infantile papular acrodermatitis [Giannotti-Crosti]	0.267	0.733	0.000
L44.3 Lichen ruber moniliformis	0.267	0.733	0.000
L44.2 Lichen striatus	0.267	0.733	0.000
L44.1 Lichen nitidus	0.267	0.733	0.000
L44.0 Pityriasis rubra pilaris	0.267	0.733	0.000
E04.2 Non-toxic multinodular goitre	0.000	0.734	0.266
T43.4 Butyrophenone and thioxanthene neuroleptics	0.266	0.734	0.000
T46 Poisoning by agents primarily affecting the cardiovascular system	0.265	0.735	0.000
E06.9 Thyroiditis, unspecified	0.000	0.737	0.263
T47 Poisoning by agents primarily affecting gastro-intestinal system	0.261	0.739	0.000
E16.9 Disorder of pancreatic internal secretion, unspecified	0.000	0.739	0.261
E16.8 Other specified disorders of pancreatic internal secretion	0.000	0.739	0.261
E16.4 Abnormal secretion of gastrin	0.000	0.739	0.261
E16.3 Increased secretion of glucagon	0.000	0.739	0.261
E16.0 Drug-induced hypoglycaemia without coma	0.000	0.739	0.261
T42.0 Hydantoin derivatives	0.258	0.742	0.000
T38.3 Insulin and oral hypoglycaemic [antidiabetic] drugs	0.256	0.744	0.000
T42.8 Anti-Parkinsonism drugs and other central muscle-tone depressants	0.251	0.749	0.000
T42.5 Mixed antiepileptics, not elsewhere classified	0.251	0.749	0.000
T42.3 Barbiturates	0.251	0.749	0.000
T42.2 Succinimides and oxazolidinediones	0.251	0.749	0.000
E21.1 Secondary hyperparathyroidism, not elsewhere classified	0.000	0.752	0.248
E21.0 Primary hyperparathyroidism	0.000	0.752	0.248
E66.1 Drug-induced obesity	0.000	0.753	0.247
E26 Hyperaldosteronism	0.000	0.754	0.246
T38.1 Thyroid hormones and substitutes	0.245	0.755	0.000
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics	0.244	0.756	0.000
E35 Disorders of endocrine glands in diseases classified elsewhere	0.000	0.756	0.244
E32 Diseases of thymus	0.000	0.756	0.244
E31 Polyglandular dysfunction	0.000	0.756	0.244
E30 Disorders of puberty, not elsewhere classified	0.000	0.756	0.244
T36 Poisoning by systemic antibiotics	0.243	0.757	0.000
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs	0.242	0.758	0.000
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system	0.242	0.758	0.000
T41 Poisoning by anaesthetics and therapeutic gases	0.242	0.758	0.000
T37 Poisoning by other systemic anti-infectives and antiparasitics	0.242	0.758	0.000
T43.2 Other and unspecified antidepressants	0.241	0.759	0.000
E16.1 Other hypoglycaemia	0.000	0.762	0.238
E22 Hyperfunction of pituitary gland	0.000	0.762	0.238
E27 Other disorders of adrenal gland	0.000	0.763	0.236
E04.8 Other specified non-toxic goitre	0.000	0.764	0.235
E66.2 Extreme obesity with alveolar hypoventilation	0.000	0.765	0.235
T43.6 Psychostimulants with abuse potential	0.233	0.766	0.000
E55.9 Vitamin D deficiency, unspecified	0.000	0.767	0.233
T43.9 Psychotropic drug, unspecified	0.232	0.768	0.000
T43.8 Other psychotropic drugs, not elsewhere classified	0.232	0.768	0.000
T43.1 Monoamine-oxidase-inhibitor antidepressants	0.232	0.768	0.000
E28 Ovarian dysfunction	0.000	0.769	0.231
E13.9 Without complications	0.000	0.769	0.230
T50.9 Other and unspecified drugs, medicaments and biological substances	0.230	0.769	0.000
E34 Other endocrine disorders	0.000	0.772	0.228
E21.5 Disorder of parathyroid gland, unspecified	0.000	0.773	0.227
E21.4 Other specified disorders of parathyroid gland	0.000	0.773	0.227
E21.2 Other hyperparathyroidism	0.000	0.773	0.227
E55.0 Rickets, active	0.000	0.774	0.226
T45.0 Antiallergic and antiemetic drugs	0.225	0.775	0.000
T44 Poisoning by drugs primarily affecting the autonomic nervous system	0.225	0.775	0.000
E29 Testicular dysfunction	0.000	0.776	0.224
E06.3 Autoimmune thyroiditis	0.000	0.777	0.223
J44 Other chronic obstructive pulmonary disease	0.000	0.778	0.222
E50.9 Vitamin A deficiency, unspecified	0.000	0.779	0.221
E50.8 Other manifestations of vitamin A deficiency	0.000	0.779	0.221
E50.7 Other ocular manifestations of vitamin A deficiency	0.000	0.779	0.221
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea	0.000	0.779	0.221
E50.5 Vitamin A deficiency with night blindness	0.000	0.779	0.221
E50.4 Vitamin A deficiency with keratomalacia	0.000	0.779	0.221
E50.3 Vitamin A deficiency with corneal ulceration and xerosis	0.000	0.779	0.221
E50.2 Vitamin A deficiency with corneal xerosis	0.000	0.779	0.221
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis	0.000	0.779	0.221
E50.0 Vitamin A deficiency with conjunctival xerosis	0.000	0.779	0.221
E51.9 Thiamine deficiency, unspecified	0.000	0.779	0.221
E51.8 Other manifestations of thiamine deficiency	0.000	0.779	0.221
E51.2 Wernicke's encephalopathy	0.000	0.779	0.221
E51.1 Beriberi	0.000	0.779	0.221
E56.9 Vitamin deficiency, unspecified	0.000	0.779	0.221
E56.8 Deficiency of other vitamins	0.000	0.779	0.221
E56.1 Deficiency of vitamin K	0.000	0.779	0.221
E56.0 Deficiency of vitamin E	0.000	0.779	0.221
E63.9 Nutritional deficiency, unspecified	0.000	0.779	0.221
E63.8 Other specified nutritional deficiencies	0.000	0.779	0.221
E63.1 Imbalance of constituents of food intake	0.000	0.779	0.221
E63.0 Essential fatty acid [EFA] deficiency	0.000	0.779	0.221
E64.9 Sequelae of unspecified nutritional deficiency	0.000	0.779	0.221
E64.8 Sequelae of other nutritional deficiencies	0.000	0.779	0.221
E64.3 Sequelae of rickets	0.000	0.779	0.221
E64.2 Sequelae of vitamin C deficiency	0.000	0.779	0.221
E64.1 Sequelae of vitamin A deficiency	0.000	0.779	0.221
E64.0 Sequelae of protein-energy malnutrition	0.000	0.779	0.221
T46.5 Other antihypertensive drugs, not elsewhere classified	0.217	0.783	0.000
T45.1 Antineoplastic and immunosuppressive drugs	0.216	0.784	0.000
T38.9 Other and unspecified hormone antagonists	0.215	0.785	0.000
T38.8 Other and unspecified hormones and their synthetic substitutes	0.215	0.785	0.000
T38.7 Androgens and anabolic congeners	0.215	0.785	0.000
T38.6 Antigonadotrophins. antioestrogens, antiandrogens, not elsewhere classified	0.215	0.785	0.000
T38.5 Other oestrogens and progestogens	0.215	0.785	0.000
T38.4 Oral contraceptives	0.215	0.785	0.000
T38.2 Antithyroid drugs	0.215	0.785	0.000
T38.0 Glucocorticoids and synthetic analogues	0.215	0.785	0.000
E20 Hypoparathyroidism	0.000	0.786	0.213
E25 Adrenogenital disorders	0.000	0.788	0.211
E66.0 Obesity due to excess calories	0.000	0.791	0.209
T47.1 Other antacids and anti-gastric-secretion drugs	0.207	0.793	0.000
E04.1 Non-toxic single thyroid nodule	0.000	0.793	0.207
E27.1 Primary adrenocortical insufficiency	0.000	0.794	0.206
T39.1 4-Aminophenol derivatives	0.204	0.796	0.000
T45.5 Anticoagulants	0.202	0.797	0.000
E27.9 Disorder of adrenal gland, unspecified	0.000	0.799	0.201
E24 Cushing's syndrome	0.000	0.800	0.200
T45.9 Primarily systemic and haematological agent, unspecified	0.200	0.800	0.000
T45.8 Other primarily systemic and haematological agents	0.200	0.800	0.000
T45.7 Anticoagulant antagonists, vitamin K and other coagulants	0.200	0.800	0.000
T45.6 Fibrinolysis-affecting drugs	0.200	0.800	0.000
T45.4 Iron and its compounds	0.200	0.800	0.000
T45.3 Enzymes, not elsewhere classified	0.200	0.800	0.000
T45.2 Vitamins, not elsewhere classified	0.200	0.800	0.000
T46.6 Antihyperlipidaemic and antiarteriosclerotic drugs	0.197	0.802	0.000
T50.8 Diagnostic agents	0.197	0.803	0.000
T50.7 Analeptics and opioid receptor antagonists	0.197	0.803	0.000
T50.6 Antidotes and chelating agents, not elsewhere classified	0.197	0.803	0.000
T50.5 Appetite depressants	0.197	0.803	0.000
T50.4 Drugs affecting uric acid metabolism	0.197	0.803	0.000
T50.3 Electrolytic, caloric and water-balance agents	0.197	0.803	0.000
T50.2 Carbonic-anhydrase inhibitors, benzothiadiazides and other diuretics	0.197	0.803	0.000
T50.1 Loop [high-ceiling] diuretics	0.197	0.803	0.000
T50.0 Mineralocorticoids and their antagonists	0.197	0.803	0.000
E61.9 Deficiency of nutrient element, unspecified	0.000	0.805	0.195
E61.8 Deficiency of other specified nutrient elements	0.000	0.805	0.195
E61.7 Deficiency of multiple nutrient elements	0.000	0.805	0.195
E61.6 Vanadium deficiency	0.000	0.805	0.195
E61.5 Molybdenum deficiency	0.000	0.805	0.195
E61.4 Chromium deficiency	0.000	0.805	0.195
E61.3 Manganese deficiency	0.000	0.805	0.195
E61.2 Magnesium deficiency	0.000	0.805	0.195
E61.0 Copper deficiency	0.000	0.805	0.195
E53.9 Vitamin B deficiency, unspecified	0.000	0.806	0.194
E53.1 Pyridoxine deficiency	0.000	0.806	0.194
E53.0 Riboflavin deficiency	0.000	0.806	0.194
T46.9 Other and unspecified agents primarily affecting the cardiovascular system	0.190	0.810	0.000
T46.8 Antivaricose drugs, including sclerosing agents	0.190	0.810	0.000
T46.7 Peripheral vasodilators	0.190	0.810	0.000
T46.3 Coronary vasodilators, not elsewhere classified	0.190	0.810	0.000
T46.2 Other antidysrhythmic drugs, not elsewhere classified	0.190	0.810	0.000
T46.0 Cardiac-stimulant glycosides and drugs of similar action	0.190	0.810	0.000
T47.9 Agent primarily affecting the gastro-intestinal system, unspecified	0.187	0.812	0.000
T47.8 Other agents primarily affecting the gastro-intestinal system	0.187	0.812	0.000
T47.7 Emetics	0.187	0.812	0.000
T47.6 Antidiarrhoeal drugs	0.187	0.812	0.000
T47.5 Digestants	0.187	0.812	0.000
T47.4 Other laxatives	0.187	0.812	0.000
T47.3 Saline and osmotic laxatives	0.187	0.812	0.000
T47.2 Stimulant laxatives	0.187	0.812	0.000
T47.0 Histamine H(2)-receptor antagonists	0.187	0.812	0.000
T46.1 Calcium-channel blockers	0.186	0.814	0.000
T46.4 Angiotensin-converting-enzyme inhibitors	0.180	0.819	0.000
E22.1 Hyperprolactinaemia	0.000	0.820	0.180
E26.0 Primary hyperaldosteronism	0.000	0.821	0.179
T43.0 Tricyclic and tetracyclic antidepressants	0.178	0.822	0.000
E26.9 Hyperaldosteronism, unspecified	0.000	0.823	0.176
E26.8 Other hyperaldosteronism	0.000	0.823	0.176
E26.1 Secondary hyperaldosteronism	0.000	0.823	0.176
T39.9 Nonopioid analgesic, antipyretic and antirheumatic, unspecified	0.176	0.824	0.000
T39.0 Salicylates	0.176	0.824	0.000
T36.0 Penicillins	0.176	0.824	0.000
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]	0.176	0.824	0.000
T39.4 Antirheumatics, not elsewhere classified	0.175	0.825	0.000
T39.2 Pyrazolone derivatives	0.175	0.825	0.000
E30.9 Disorder of puberty, unspecified	0.000	0.825	0.175
E30.8 Other disorders of puberty	0.000	0.825	0.175
E30.1 Precocious puberty	0.000	0.825	0.175
E30.0 Delayed puberty	0.000	0.825	0.175
E31.9 Polyglandular dysfunction, unspecified	0.000	0.825	0.175
E31.8 Other polyglandular dysfunction	0.000	0.825	0.175
E31.1 Polyglandular hyperfunction	0.000	0.825	0.175
E31.0 Autoimmune polyglandular failure	0.000	0.825	0.175
E32.9 Disease of thymus, unspecified	0.000	0.825	0.175
E32.8 Other diseases of thymus	0.000	0.825	0.175
E32.1 Abscess of thymus	0.000	0.825	0.175
E32.0 Persistent hyperplasia of thymus	0.000	0.825	0.175
E35.8 Disorders of other endocrine glands in diseases classified elsewhere	0.000	0.825	0.175
E35.1 Disorders of adrenal glands in diseases classified elsewhere	0.000	0.825	0.175
E35.0 Disorders of thyroid gland in diseases classified elsewhere	0.000	0.825	0.175
T36.9 Systemic antibiotic, unspecified	0.174	0.825	0.000
T36.8 Other systemic antibiotics	0.174	0.825	0.000
T36.7 Antifungal antibiotics, systemically used	0.174	0.825	0.000
T36.6 Rifamycins	0.174	0.825	0.000
T36.5 Aminoglycosides	0.174	0.825	0.000
T36.4 Tetracyclines	0.174	0.825	0.000
T36.3 Macrolides	0.174	0.825	0.000
T36.2 Chloramphenicol group	0.174	0.825	0.000
T36.1 Cefalosporins and other Beta-lactam antibiotics	0.174	0.825	0.000
T37.9 Systemic anti-infective and antiparasitic, unspecified	0.174	0.826	0.000
T37.8 Other specified systemic anti-infectives and antiparasitics	0.174	0.826	0.000
T37.5 Antiviral drugs	0.174	0.826	0.000
T37.4 Anthelminthics	0.174	0.826	0.000
T37.3 Other antiprotozoal drugs	0.174	0.826	0.000
T37.2 Antimalarials and drugs acting on other blood protozoa	0.174	0.826	0.000
T37.1 Antimycobacterial drugs	0.174	0.826	0.000
T37.0 Sulphonamides	0.174	0.826	0.000
T41.5 Therapeutic gases	0.174	0.826	0.000
T41.4 Anaesthetic, unspecified	0.174	0.826	0.000
T41.3 Local anaesthetics	0.174	0.826	0.000
T41.2 Other and unspecified general anaesthetics	0.174	0.826	0.000
T41.1 Intravenous anaesthetics	0.174	0.826	0.000
T41.0 Inhaled anaesthetics	0.174	0.826	0.000
T48.7 Other and unspecified agents primarily acting on the respiratory system	0.174	0.826	0.000
T48.6 Antiasthmatics, not elsewhere classified	0.174	0.826	0.000
T48.5 Anti-common-cold drugs	0.174	0.826	0.000
T48.4 Expectorants	0.174	0.826	0.000
T48.3 Antitussives	0.174	0.826	0.000
T48.2 Other and unspecified agents primarily acting on muscles	0.174	0.826	0.000
T48.1 Skeletal muscle relaxants [neuromuscular blocking agents]	0.174	0.826	0.000
T48.0 Oxytocic drugs	0.174	0.826	0.000
T49.9 Topical agent, unspecified	0.174	0.826	0.000
T49.8 Other topical agents	0.174	0.826	0.000
T49.7 Dental drugs, topically applied	0.174	0.826	0.000
T49.6 Otorhinolaryngological drugs and preparations	0.174	0.826	0.000
T49.5 Ophthalmological drugs and preparations	0.174	0.826	0.000
T49.4 Keratolytics, keratoplastics and other hair treatment drugs and preparations	0.174	0.826	0.000
T49.3 Emollients, demulcents and protectants	0.174	0.826	0.000
T49.2 Local astringents and local detergents	0.174	0.826	0.000
T49.1 Antipruritics	0.174	0.826	0.000
T49.0 Local antifungal, anti-infective and anti-inflammatory drugs, not elsewhere classified	0.174	0.826	0.000
J44.8 Other specified chronic obstructive pulmonary disease	0.000	0.828	0.172
E22.9 Hyperfunction of pituitary gland, unspecified	0.000	0.829	0.170
E22.8 Other hyperfunction of pituitary gland	0.000	0.829	0.170
E27.5 Adrenomedullary hyperfunction	0.000	0.830	0.170
E27.0 Other adrenocortical overactivity	0.000	0.830	0.170
E22.0 Acromegaly and pituitary gigantism	0.000	0.830	0.169
E28.9 Ovarian dysfunction, unspecified	0.000	0.834	0.165
E28.8 Other ovarian dysfunction	0.000	0.834	0.165
E28.1 Androgen excess	0.000	0.834	0.165
E28.0 Oestrogen excess	0.000	0.834	0.165
E28.3 Primary ovarian failure	0.000	0.835	0.165
E34.8 Other specified endocrine disorders	0.000	0.836	0.164
E34.5 Androgen resistance syndrome	0.000	0.836	0.164
E34.4 Constitutional tall stature	0.000	0.836	0.164
E34.3 Short stature, not elsewhere classified	0.000	0.836	0.164
E34.2 Ectopic hormone secretion, not elsewhere classified	0.000	0.836	0.164
E34.1 Other hypersecretion of intestinal hormones	0.000	0.836	0.164
E34.0 Carcinoid syndrome	0.000	0.836	0.164
T44.3 Other parasympatholytics [anticholinergics and antimuscarines] and spasmolytics, not elsewhere classified	0.163	0.837	0.000
T44.9 Other and unspecified drugs primarily affecting the nervous system	0.161	0.839	0.000
T44.8 Centrally acting and afrenergic-neuron-blocking agents, not elsewhere classified	0.161	0.839	0.000
T44.6 Alpha-Adrenoreceeptor antagonists, not elsewhere classified	0.161	0.839	0.000
T44.5 Predominantly Beta-adrenoreceptor agonists, not elsewhere classified	0.161	0.839	0.000
T44.4 Predominantly Alpha-adrenoreceptor agonists, not elsewhere classified	0.161	0.839	0.000
T44.2 Ganglionic blocking drugs, not elsewhere classified	0.161	0.839	0.000
T44.1 Other parasympathomimetics [cholinergics]	0.161	0.839	0.000
T44.0 Anticholinesterase agents	0.161	0.839	0.000
E29.9 Testicular dysfunction, unspecified	0.000	0.839	0.161
E29.8 Other testicular dysfunction	0.000	0.839	0.161
E29.0 Testicular hyperfunction	0.000	0.839	0.161
E61.1 Iron deficiency	0.000	0.840	0.160
T39.8 Other nonopioid analgesics and antipyretics, not elsewhere classified	0.158	0.842	0.000
E27.8 Other specified disorders of adrenal gland	0.000	0.842	0.158
E53.8 Deficiency of other specified B group vitamins	0.000	0.844	0.156
E04.9 Non-toxic goitre, unspecified	0.000	0.844	0.156
E04.0 Non-toxic diffuse goitre	0.001	0.845	0.155
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone	0.000	0.846	0.153
E28.2 Polycystic ovarian syndrome	0.000	0.847	0.153
E20.8 Other hypoparathyroidism	0.000	0.847	0.153
E20.1 Pseudohypoparathyroidism	0.000	0.847	0.153
E20.0 Idiopathic hypoparathyroidism	0.000	0.847	0.153
E25.9 Adrenogenital disorder, unspecified	0.000	0.848	0.152
E25.8 Other adrenogenital disorders	0.000	0.848	0.152
E27.3 Drug-induced adrenocortical insufficiency	0.000	0.849	0.151
T39.3 Other nonsteroidal anti-inflammatory drugs [NSAID]	0.150	0.850	0.000
E34.9 Endocrine disorder, unspecified	0.000	0.852	0.148
E24.8 Other Cushing's syndrome	0.000	0.856	0.143
E24.4 Alcohol-induced pseudo-Cushing's syndrome	0.000	0.856	0.143
E24.3 Ectopic ACTH syndrome	0.000	0.856	0.143
E24.1 Nelson's syndrome	0.000	0.856	0.143
E24.0 Pituitary-dependent Cushing's disease	0.000	0.856	0.143
T44.7 Beta-Adrenoreceeptor antagonists, not elsewhere classified	0.142	0.858	0.000
E29.1 Testicular hypofunction	0.000	0.858	0.141
J44.0 Chronic obstructive pulmonary disease with acute lower respiratory infection	0.000	0.862	0.138
T40.6 Other and unspecified narcotics	0.133	0.867	0.000
E27.4 Other and unspecified adrenocortical insufficiency	0.000	0.870	0.130
E24.9 Cushing's syndrome, unspecified	0.000	0.873	0.126
T40.9 Other and unspecified psychodysleptics [hallucinogens]	0.126	0.874	0.000
T40.8 Lysergide [LSD]	0.126	0.874	0.000
T40.7 Cannabis (derivatives)	0.126	0.874	0.000
T40.5 Cocaine	0.126	0.874	0.000
T40.3 Methadone	0.126	0.874	0.000
T40.1 Heroin	0.126	0.874	0.000
T40.0 Opium	0.126	0.874	0.000
E24.2 Drug-induced Cushing's syndrome	0.000	0.876	0.123
E20.9 Hypoparathyroidism, unspecified	0.000	0.877	0.123
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency	0.001	0.880	0.119
E27.2 Addisonian crisis	0.001	0.892	0.107
E23 Hypofunction and other disorders of pituitary gland	0.001	0.894	0.105
J44.1 Chronic obstructive pulmonary disease with acute exacerbation, unspecified	0.000	0.902	0.098
T40.2 Other opioids	0.098	0.902	0.000
T40.4 Other synthetic narcotics	0.091	0.909	0.000
M07.39 Other psoriatic arthropathies (Site unspecified)	0.084	0.916	0.000
M07.3 Other psoriatic arthropathies	0.083	0.917	0.000
M07.30 Other psoriatic arthropathies (Multiple sites)	0.081	0.919	0.000
E23.3 Hypothalamic dysfunction, not elsewhere classified	0.001	0.924	0.076
E23.1 Drug-induced hypopituitarism	0.001	0.924	0.076
E23.7 Disorder of pituitary gland, unspecified	0.001	0.927	0.072
M07.36 Other psoriatic arthropathies (Lower leg)	0.070	0.930	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations