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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs12212418
log Bayes Factor = 37.1843
Chromosome 6   position 30,924,024  (GRCh37) Explore rs12212418 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
K90.0 Coeliac disease
0.000 0.000 1.000
L40.9 Psoriasis, unspecified
1.000 0.000 0.000
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
L40 Psoriasis
1.000 0.000 0.000
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
L40.5 Arthropathic psoriasis
1.000 0.000 0.000
E03 Other hypothyroidism
0.000 0.000 1.000
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.000 1.000
E05.9 Thyrotoxicosis, unspecified
0.000 0.001 0.999
L40.0 Psoriasis vulgaris
0.991 0.009 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.018 0.982
E50-E64 Other nutritional deficiencies
0.000 0.026 0.974
E10 Insulin-dependent diabetes mellitus
0.000 0.028 0.972
E10-E14 Diabetes mellitus
0.000 0.029 0.971
E53 Deficiency of other B group vitamins
0.000 0.032 0.968
E53.8 Deficiency of other specified B group vitamins
0.000 0.037 0.963
E10.9 Without complications
0.000 0.039 0.961
E10.5 With peripheral circulatory complications
0.000 0.060 0.940
E10.4 With neurological complications
0.000 0.116 0.884
E04 Other non-toxic goitre
0.000 0.135 0.865
E55 Vitamin D deficiency
0.000 0.177 0.823
L40.8 Other psoriasis
0.810 0.190 0.000
E07 Other disorders of thyroid
0.000 0.195 0.805
L40.4 Guttate psoriasis
0.799 0.201 0.000
L40.1 Generalised pustular psoriasis
0.787 0.213 0.000
E06 Thyroiditis
0.000 0.215 0.785
E53.9 Vitamin B deficiency, unspecified
0.000 0.234 0.766
E04.9 Non-toxic goitre, unspecified
0.000 0.248 0.752
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.253 0.747
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.263 0.737
E10.6 With other specified complications
0.000 0.266 0.734
E04.2 Non-toxic multinodular goitre
0.000 0.266 0.734
E10.0 With coma
0.000 0.275 0.724
E10.2 With renal complications
0.000 0.279 0.721
E04.0 Non-toxic diffuse goitre
0.000 0.280 0.720
E05.5 Thyroid crisis or storm
0.000 0.283 0.717
E05.4 Thyrotoxicosis factitia
0.000 0.283 0.717
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.283 0.717
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.283 0.717
L40.2 Acrodermatitis continua
0.717 0.283 0.000
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
E03.5 Myxoedema coma
0.000 0.283 0.717
E03.4 Atrophy of thyroid (acquired)
0.000 0.283 0.717
E03.3 Postinfectious hypothyroidism
0.000 0.283 0.717
E58 Dietary calcium deficiency
0.000 0.283 0.717
E55.9 Vitamin D deficiency, unspecified
0.000 0.285 0.715
L40.3 Pustulosis palmaris et plantaris
0.715 0.285 0.000
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.286 0.714
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.302 0.698
E63 Other nutritional deficiencies
0.000 0.302 0.698
E51 Thiamine deficiency
0.000 0.302 0.698
E50 Vitamin A deficiency
0.000 0.302 0.698
E60 Dietary zinc deficiency
0.000 0.302 0.698
E59 Dietary selenium deficiency
0.000 0.302 0.698
E54 Ascorbic acid deficiency
0.000 0.302 0.698
E52 Niacin deficiency [pellagra]
0.000 0.302 0.698
E10.7 With multiple complications
0.000 0.303 0.697
E12 Malnutrition-related diabetes mellitus
0.000 0.304 0.696
E53.1 Pyridoxine deficiency
0.000 0.306 0.694
E53.0 Riboflavin deficiency
0.000 0.306 0.694
E10.3 With ophthalmic complications
0.000 0.313 0.687
E03.1 Congenital hypothyroidism without goitre
0.000 0.325 0.675
E06.3 Autoimmune thyroiditis
0.000 0.326 0.674
E56 Other vitamin deficiencies
0.000 0.329 0.671
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.331 0.669
E07.9 Disorder of thyroid, unspecified
0.000 0.345 0.655
E03.8 Other specified hypothyroidism
0.000 0.377 0.623
E13 Other specified diabetes mellitus
0.000 0.377 0.623
E04.8 Other specified non-toxic goitre
0.000 0.379 0.620
E20-E35 Disorders of other endocrine glands
0.000 0.392 0.608
E10.1 With ketoacidosis
0.000 0.401 0.599
E10.8 With unspecified complications
0.000 0.403 0.596
E07.8 Other specified disorders of thyroid
0.000 0.409 0.591
E55.0 Rickets, active
0.000 0.410 0.590
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.415 0.584
E07.1 Dyshormogenetic goitre
0.000 0.423 0.577
E07.0 Hypersecretion of calcitonin
0.000 0.423 0.577
E06.4 Drug-induced thyroiditis
0.000 0.437 0.563
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.437 0.563
E06.0 Acute thyroiditis
0.000 0.437 0.563
E27 Other disorders of adrenal gland
0.000 0.438 0.562
E05.8 Other thyrotoxicosis
0.000 0.440 0.560
E06.9 Thyroiditis, unspecified
0.000 0.444 0.556
E27.1 Primary adrenocortical insufficiency
0.000 0.444 0.556
E06.5 Other chronic thyroiditis
0.000 0.446 0.554
E65-E68 Obesity and other hyperalimentation
0.000 0.456 0.544
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.470 0.530
E40-E46 Malnutrition
0.000 0.471 0.528
E61 Deficiency of other nutrient elements
0.000 0.478 0.522
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.486 0.514
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.486 0.514
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.486 0.514
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.486 0.514
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.486 0.514
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.486 0.514
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.486 0.514
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.486 0.514
E50.9 Vitamin A deficiency, unspecified
0.000 0.499 0.501
E50.8 Other manifestations of vitamin A deficiency
0.000 0.499 0.501
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.499 0.501
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.499 0.501
E50.5 Vitamin A deficiency with night blindness
0.000 0.499 0.501
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.499 0.501
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.499 0.501
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.499 0.501
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.499 0.501
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.499 0.501
E51.9 Thiamine deficiency, unspecified
0.000 0.499 0.501
E51.8 Other manifestations of thiamine deficiency
0.000 0.499 0.501
E51.2 Wernicke's encephalopathy
0.000 0.499 0.501
E51.1 Beriberi
0.000 0.499 0.501
E63.9 Nutritional deficiency, unspecified
0.000 0.499 0.501
E63.8 Other specified nutritional deficiencies
0.000 0.499 0.501
E63.1 Imbalance of constituents of food intake
0.000 0.499 0.501
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.499 0.501
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.499 0.501
E64.8 Sequelae of other nutritional deficiencies
0.000 0.499 0.501
E64.3 Sequelae of rickets
0.000 0.499 0.501
E64.2 Sequelae of vitamin C deficiency
0.000 0.499 0.501
E64.1 Sequelae of vitamin A deficiency
0.000 0.499 0.501
E64.0 Sequelae of protein-energy malnutrition
0.000 0.499 0.501
E12.9 Without complications
0.000 0.501 0.499
E12.8 With unspecified complications
0.000 0.501 0.499
E12.7 With multiple complications
0.000 0.501 0.499
E12.6 With other specified complications
0.000 0.501 0.499
E12.5 With peripheral circulatory complications
0.000 0.501 0.499
E12.4 With neurological complications
0.000 0.501 0.499
E12.3 With ophthalmic complications
0.000 0.501 0.499
E12.2 With renal complications
0.000 0.501 0.499
E12.1 With ketoacidosis
0.000 0.501 0.499
E12.0 With coma
0.000 0.501 0.499
E06.1 Subacute thyroiditis
0.000 0.505 0.495
E21.3 Hyperparathyroidism, unspecified
0.000 0.509 0.491
E56.9 Vitamin deficiency, unspecified
0.000 0.519 0.481
E56.8 Deficiency of other vitamins
0.000 0.519 0.481
E56.0 Deficiency of vitamin E
0.000 0.519 0.481
E15 Nondiabetic hypoglycaemic coma
0.000 0.520 0.480
E20 Hypoparathyroidism
0.000 0.540 0.460
K90 Intestinal malabsorption
0.000 0.543 0.457
E27.2 Addisonian crisis
0.000 0.545 0.455
E56.1 Deficiency of vitamin K
0.000 0.546 0.454
E21.0 Primary hyperparathyroidism
0.000 0.548 0.452
T43 Poisoning by psychotropic drugs, not elsewhere classified
0.452 0.548 0.000
T36-T50 Poisoning by drugs, medicaments and biological substances
0.449 0.551 0.000
E34 Other endocrine disorders
0.000 0.552 0.448
E13.8 With unspecified complications
0.000 0.553 0.446
E13.7 With multiple complications
0.000 0.553 0.446
E13.6 With other specified complications
0.000 0.553 0.446
E13.5 With peripheral circulatory complications
0.000 0.553 0.446
E13.4 With neurological complications
0.000 0.553 0.446
E13.3 With ophthalmic complications
0.000 0.553 0.446
E13.2 With renal complications
0.000 0.553 0.446
E13.1 With ketoacidosis
0.000 0.553 0.446
E13.0 With coma
0.000 0.553 0.446
E16 Other disorders of pancreatic internal secretion
0.000 0.555 0.445
T44 Poisoning by drugs primarily affecting the autonomic nervous system
0.441 0.559 0.000
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.564 0.436
E32 Diseases of thymus
0.000 0.564 0.436
E31 Polyglandular dysfunction
0.000 0.564 0.436
E30 Disorders of puberty, not elsewhere classified
0.000 0.564 0.436
T46 Poisoning by agents primarily affecting the cardiovascular system
0.430 0.570 0.000
T43.2 Other and unspecified antidepressants
0.423 0.577 0.000
T43.0 Tricyclic and tetracyclic antidepressants
0.420 0.580 0.000
E14 Unspecified diabetes mellitus
0.000 0.581 0.419
T44.7 Beta-Adrenoreceeptor antagonists, not elsewhere classified
0.417 0.583 0.000
E28 Ovarian dysfunction
0.000 0.587 0.413
T43.6 Psychostimulants with abuse potential
0.407 0.593 0.000
E27.5 Adrenomedullary hyperfunction
0.000 0.597 0.403
E27.0 Other adrenocortical overactivity
0.000 0.597 0.403
T44.3 Other parasympatholytics [anticholinergics and antimuscarines] and spasmolytics, not elsewhere classified
0.402 0.598 0.000
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.604 0.396
T46.4 Angiotensin-converting-enzyme inhibitors
0.393 0.607 0.000
T43.4 Butyrophenone and thioxanthene neuroleptics
0.393 0.607 0.000
E67 Other hyperalimentation
0.000 0.610 0.390
E68 Sequelae of hyperalimentation
0.000 0.610 0.390
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.610 0.390
T47 Poisoning by agents primarily affecting gastro-intestinal system
0.390 0.610 0.000
E26 Hyperaldosteronism
0.000 0.613 0.386
E22 Hyperfunction of pituitary gland
0.000 0.616 0.384
E21.2 Other hyperparathyroidism
0.000 0.620 0.380
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.621 0.379
E45 Retarded development following protein-energy malnutrition
0.000 0.621 0.379
E43 Unspecified severe protein-energy malnutrition
0.000 0.621 0.379
E42 Marasmic kwashiorkor
0.000 0.621 0.379
E41 Nutritional marasmus
0.000 0.621 0.379
E40 Kwashiorkor
0.000 0.621 0.379
E61.9 Deficiency of nutrient element, unspecified
0.000 0.626 0.374
E61.8 Deficiency of other specified nutrient elements
0.000 0.626 0.374
E61.7 Deficiency of multiple nutrient elements
0.000 0.626 0.374
E61.6 Vanadium deficiency
0.000 0.626 0.374
E61.5 Molybdenum deficiency
0.000 0.626 0.374
E61.4 Chromium deficiency
0.000 0.626 0.374
E61.3 Manganese deficiency
0.000 0.626 0.374
E61.0 Copper deficiency
0.000 0.626 0.374
E65 Localised adiposity
0.000 0.627 0.373
E13.9 Without complications
0.000 0.627 0.373
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances
0.372 0.628 0.000
E25 Adrenogenital disorders
0.000 0.635 0.365
T46.1 Calcium-channel blockers
0.361 0.638 0.000
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system
0.358 0.642 0.000
E20.9 Hypoparathyroidism, unspecified
0.000 0.646 0.354
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.648 0.352
E34.8 Other specified endocrine disorders
0.000 0.649 0.351
E29 Testicular dysfunction
0.000 0.651 0.349
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.652 0.348
T46.5 Other antihypertensive drugs, not elsewhere classified
0.346 0.654 0.000
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs
0.343 0.657 0.000
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.340 0.660 0.000
E28.3 Primary ovarian failure
0.000 0.661 0.339
T43.1 Monoamine-oxidase-inhibitor antidepressants
0.338 0.662 0.000
E34.9 Endocrine disorder, unspecified
0.000 0.663 0.337
E21.4 Other specified disorders of parathyroid gland
0.000 0.666 0.334
T47.4 Other laxatives
0.331 0.669 0.000
E20.8 Other hypoparathyroidism
0.000 0.670 0.330
E20.1 Pseudohypoparathyroidism
0.000 0.670 0.330
E20.0 Idiopathic hypoparathyroidism
0.000 0.670 0.330
T44.9 Other and unspecified drugs primarily affecting the nervous system
0.329 0.671 0.000
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified
0.329 0.671 0.000
K90.3 Pancreatic steatorrhoea
0.000 0.672 0.328
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.672 0.328
K90.1 Tropical sprue
0.000 0.672 0.328
E14.8 With unspecified complications
0.000 0.673 0.327
E27.8 Other specified disorders of adrenal gland
0.000 0.674 0.326
T43.9 Psychotropic drug, unspecified
0.324 0.676 0.000
T43.8 Other psychotropic drugs, not elsewhere classified
0.324 0.676 0.000
L40-L45 Papulosquamous disorders
0.322 0.678 0.000
T41 Poisoning by anaesthetics and therapeutic gases
0.322 0.678 0.000
T37 Poisoning by other systemic anti-infectives and antiparasitics
0.322 0.678 0.000
E34.5 Androgen resistance syndrome
0.000 0.678 0.322
E34.4 Constitutional tall stature
0.000 0.678 0.322
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.678 0.322
E34.1 Other hypersecretion of intestinal hormones
0.000 0.678 0.322
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.681 0.319
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.681 0.319
E16.4 Abnormal secretion of gastrin
0.000 0.681 0.319
E16.3 Increased secretion of glucagon
0.000 0.681 0.319
T44.6 Alpha-Adrenoreceeptor antagonists, not elsewhere classified
0.319 0.681 0.000
T46.6 Antihyperlipidaemic and antiarteriosclerotic drugs
0.316 0.684 0.000
T44.8 Centrally acting and afrenergic-neuron-blocking agents, not elsewhere classified
0.316 0.684 0.000
T44.5 Predominantly Beta-adrenoreceptor agonists, not elsewhere classified
0.316 0.684 0.000
T44.4 Predominantly Alpha-adrenoreceptor agonists, not elsewhere classified
0.316 0.684 0.000
T44.2 Ganglionic blocking drugs, not elsewhere classified
0.316 0.684 0.000
T44.1 Other parasympathomimetics [cholinergics]
0.316 0.684 0.000
T44.0 Anticholinesterase agents
0.316 0.684 0.000
E61.2 Magnesium deficiency
0.000 0.685 0.315
T50.9 Other and unspecified drugs, medicaments and biological substances
0.315 0.685 0.000
E14.5 With peripheral circulatory complications
0.000 0.686 0.314
E30.9 Disorder of puberty, unspecified
0.000 0.687 0.312
E30.8 Other disorders of puberty
0.000 0.687 0.312
E30.1 Precocious puberty
0.000 0.687 0.312
E30.0 Delayed puberty
0.000 0.687 0.312
E31.9 Polyglandular dysfunction, unspecified
0.000 0.687 0.312
E31.8 Other polyglandular dysfunction
0.000 0.687 0.312
E31.1 Polyglandular hyperfunction
0.000 0.687 0.312
E31.0 Autoimmune polyglandular failure
0.000 0.687 0.312
E32.9 Disease of thymus, unspecified
0.000 0.687 0.312
E32.8 Other diseases of thymus
0.000 0.687 0.312
E32.1 Abscess of thymus
0.000 0.687 0.312
E32.0 Persistent hyperplasia of thymus
0.000 0.687 0.312
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.687 0.312
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.687 0.312
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.687 0.312
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs
0.312 0.688 0.000
T36 Poisoning by systemic antibiotics
0.311 0.689 0.000
E14.1 With ketoacidosis
0.000 0.691 0.309
E14.6 With other specified complications
0.000 0.691 0.309
T46.9 Other and unspecified agents primarily affecting the cardiovascular system
0.308 0.692 0.000
T46.8 Antivaricose drugs, including sclerosing agents
0.308 0.692 0.000
T46.7 Peripheral vasodilators
0.308 0.692 0.000
T46.2 Other antidysrhythmic drugs, not elsewhere classified
0.308 0.692 0.000
T46.0 Cardiac-stimulant glycosides and drugs of similar action
0.308 0.692 0.000
E14.3 With ophthalmic complications
0.000 0.692 0.308
E16.2 Hypoglycaemia, unspecified
0.000 0.695 0.305
E34.3 Short stature, not elsewhere classified
0.000 0.697 0.303
E34.0 Carcinoid syndrome
0.000 0.698 0.302
T43.5 Other and unspecified antipsychotics and neuroleptics
0.301 0.699 0.000
E14.7 With multiple complications
0.000 0.700 0.300
E14.0 With coma
0.000 0.700 0.300
T47.1 Other antacids and anti-gastric-secretion drugs
0.299 0.701 0.000
T46.3 Coronary vasodilators, not elsewhere classified
0.298 0.702 0.000
E22.1 Hyperprolactinaemia
0.000 0.703 0.297
E28.9 Ovarian dysfunction, unspecified
0.000 0.704 0.296
E28.8 Other ovarian dysfunction
0.000 0.704 0.296
E28.1 Androgen excess
0.000 0.704 0.296
E28.0 Oestrogen excess
0.000 0.704 0.296
T45.0 Antiallergic and antiemetic drugs
0.293 0.707 0.000
T47.2 Stimulant laxatives
0.293 0.707 0.000
T48.5 Anti-common-cold drugs
0.293 0.707 0.000
T50.6 Antidotes and chelating agents, not elsewhere classified
0.291 0.709 0.000
E61.1 Iron deficiency
0.000 0.710 0.290
E23 Hypofunction and other disorders of pituitary gland
0.000 0.710 0.290
K90.9 Intestinal malabsorption, unspecified
0.000 0.715 0.285
T43.3 Phenothiazine antipsychotics and neuroleptics
0.285 0.715 0.000
E67.8 Other specified hyperalimentation
0.000 0.720 0.279
E67.3 Hypervitaminosis D
0.000 0.720 0.279
E67.2 Megavitamin-B6 syndrome
0.000 0.720 0.279
E67.1 Hypercarotenaemia
0.000 0.720 0.279
E67.0 Hypervitaminosis A
0.000 0.720 0.279
T47.9 Agent primarily affecting the gastro-intestinal system, unspecified
0.279 0.720 0.000
T47.8 Other agents primarily affecting the gastro-intestinal system
0.279 0.720 0.000
T47.7 Emetics
0.279 0.720 0.000
T47.6 Antidiarrhoeal drugs
0.279 0.720 0.000
T47.5 Digestants
0.279 0.720 0.000
T47.3 Saline and osmotic laxatives
0.279 0.720 0.000
T47.0 Histamine H(2)-receptor antagonists
0.279 0.720 0.000
E14.2 Withrenal complications
0.000 0.722 0.277
E26.8 Other hyperaldosteronism
0.000 0.723 0.277
E26.1 Secondary hyperaldosteronism
0.000 0.723 0.277
T50.2 Carbonic-anhydrase inhibitors, benzothiadiazides and other diuretics
0.276 0.724 0.000
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.725 0.275
E22.8 Other hyperfunction of pituitary gland
0.000 0.725 0.275
T38.3 Insulin and oral hypoglycaemic [antidiabetic] drugs
0.274 0.725 0.000
E44.1 Mild protein-energy malnutrition
0.000 0.728 0.272
E44.0 Moderate protein-energy malnutrition
0.000 0.728 0.272
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.730 0.270
K90.8 Other intestinal malabsorption
0.000 0.730 0.270
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.731 0.269
E26.9 Hyperaldosteronism, unspecified
0.000 0.732 0.268
T49.0 Local antifungal, anti-infective and anti-inflammatory drugs, not elsewhere classified
0.267 0.733 0.000
T50.7 Analeptics and opioid receptor antagonists
0.267 0.733 0.000
T50.5 Appetite depressants
0.267 0.733 0.000
T50.3 Electrolytic, caloric and water-balance agents
0.267 0.733 0.000
T50.1 Loop [high-ceiling] diuretics
0.267 0.733 0.000
T50.0 Mineralocorticoids and their antagonists
0.267 0.733 0.000
T42.7 Antiepileptic and sedative-hypnotic drugs, unspecified
0.266 0.734 0.000
T50.8 Diagnostic agents
0.265 0.735 0.000
E25.9 Adrenogenital disorder, unspecified
0.000 0.738 0.262
E25.8 Other adrenogenital disorders
0.000 0.738 0.262
E66 Obesity
0.000 0.740 0.260
L42 Pityriasis rosea
0.259 0.741 0.000
E16.1 Other hypoglycaemia
0.000 0.743 0.257
T42.8 Anti-Parkinsonism drugs and other central muscle-tone depressants
0.257 0.743 0.000
T48.7 Other and unspecified agents primarily acting on the respiratory system
0.257 0.743 0.000
T48.6 Antiasthmatics, not elsewhere classified
0.257 0.743 0.000
T48.4 Expectorants
0.257 0.743 0.000
T48.3 Antitussives
0.257 0.743 0.000
T48.2 Other and unspecified agents primarily acting on muscles
0.257 0.743 0.000
T48.1 Skeletal muscle relaxants [neuromuscular blocking agents]
0.257 0.743 0.000
T48.0 Oxytocic drugs
0.257 0.743 0.000
T45.1 Antineoplastic and immunosuppressive drugs
0.254 0.746 0.000
E29.9 Testicular dysfunction, unspecified
0.000 0.750 0.250
E29.8 Other testicular dysfunction
0.000 0.750 0.250
E29.0 Testicular hyperfunction
0.000 0.750 0.250
T49.9 Topical agent, unspecified
0.246 0.754 0.000
T49.8 Other topical agents
0.246 0.754 0.000
T49.7 Dental drugs, topically applied
0.246 0.754 0.000
T49.6 Otorhinolaryngological drugs and preparations
0.246 0.754 0.000
T49.5 Ophthalmological drugs and preparations
0.246 0.754 0.000
T49.4 Keratolytics, keratoplastics and other hair treatment drugs and preparations
0.246 0.754 0.000
T49.3 Emollients, demulcents and protectants
0.246 0.754 0.000
T49.2 Local astringents and local detergents
0.246 0.754 0.000
T49.1 Antipruritics
0.246 0.754 0.000
T38.9 Other and unspecified hormone antagonists
0.244 0.756 0.000
T38.8 Other and unspecified hormones and their synthetic substitutes
0.244 0.756 0.000
T38.7 Androgens and anabolic congeners
0.244 0.756 0.000
T38.6 Antigonadotrophins. antioestrogens, antiandrogens, not elsewhere classified
0.244 0.756 0.000
T38.5 Other oestrogens and progestogens
0.244 0.756 0.000
T38.4 Oral contraceptives
0.244 0.756 0.000
T38.2 Antithyroid drugs
0.244 0.756 0.000
T38.0 Glucocorticoids and synthetic analogues
0.244 0.756 0.000
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.758 0.242
E26.0 Primary hyperaldosteronism
0.000 0.759 0.241
T42.3 Barbiturates
0.239 0.761 0.000
T45.9 Primarily systemic and haematological agent, unspecified
0.236 0.764 0.000
T45.8 Other primarily systemic and haematological agents
0.236 0.764 0.000
T45.7 Anticoagulant antagonists, vitamin K and other coagulants
0.236 0.764 0.000
T45.6 Fibrinolysis-affecting drugs
0.236 0.764 0.000
T45.4 Iron and its compounds
0.236 0.764 0.000
T45.3 Enzymes, not elsewhere classified
0.236 0.764 0.000
E24 Cushing's syndrome
0.001 0.769 0.231
L44 Other papulosquamous disorders
0.231 0.769 0.000
L41 Parapsoriasis
0.231 0.769 0.000
L45 Papulosquamous disorders in diseases classified elsewhere
0.231 0.769 0.000
E22.0 Acromegaly and pituitary gigantism
0.000 0.769 0.231
T37.9 Systemic anti-infective and antiparasitic, unspecified
0.231 0.769 0.000
T37.8 Other specified systemic anti-infectives and antiparasitics
0.231 0.769 0.000
T37.5 Antiviral drugs
0.231 0.769 0.000
T37.4 Anthelminthics
0.231 0.769 0.000
T37.3 Other antiprotozoal drugs
0.231 0.769 0.000
T37.2 Antimalarials and drugs acting on other blood protozoa
0.231 0.769 0.000
T37.1 Antimycobacterial drugs
0.231 0.769 0.000
T37.0 Sulphonamides
0.231 0.769 0.000
T41.5 Therapeutic gases
0.231 0.769 0.000
T41.4 Anaesthetic, unspecified
0.231 0.769 0.000
T41.3 Local anaesthetics
0.231 0.769 0.000
T41.2 Other and unspecified general anaesthetics
0.231 0.769 0.000
T41.1 Intravenous anaesthetics
0.231 0.769 0.000
T41.0 Inhaled anaesthetics
0.231 0.769 0.000
T50.4 Drugs affecting uric acid metabolism
0.230 0.770 0.000
T38.1 Thyroid hormones and substitutes
0.227 0.773 0.000
E66.8 Other obesity
0.000 0.775 0.225
T42.5 Mixed antiepileptics, not elsewhere classified
0.223 0.776 0.000
T42.2 Succinimides and oxazolidinediones
0.223 0.776 0.000
E27.9 Disorder of adrenal gland, unspecified
0.001 0.777 0.223
T36.9 Systemic antibiotic, unspecified
0.223 0.777 0.000
T36.8 Other systemic antibiotics
0.223 0.777 0.000
T36.7 Antifungal antibiotics, systemically used
0.223 0.777 0.000
T36.6 Rifamycins
0.223 0.777 0.000
T36.5 Aminoglycosides
0.223 0.777 0.000
T36.4 Tetracyclines
0.223 0.777 0.000
T36.3 Macrolides
0.223 0.777 0.000
T36.2 Chloramphenicol group
0.223 0.777 0.000
T36.1 Cefalosporins and other Beta-lactam antibiotics
0.223 0.777 0.000
T36.0 Penicillins
0.212 0.788 0.000
T42.6 Other antiepileptic and sedative-hypnotic drugs
0.210 0.790 0.000
T45.2 Vitamins, not elsewhere classified
0.209 0.790 0.000
E14.4 With neurological complications
0.000 0.791 0.209
E04.1 Non-toxic single thyroid nodule
0.000 0.791 0.208
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.792 0.208
E23.1 Drug-induced hypopituitarism
0.000 0.792 0.208
E46 Unspecified protein-energy malnutrition
0.001 0.796 0.204
E23.7 Disorder of pituitary gland, unspecified
0.000 0.801 0.199
T42.1 Iminostilbenes
0.196 0.804 0.000
E28.2 Polycystic ovarian syndrome
0.000 0.806 0.193
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.001 0.808 0.191
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics
0.191 0.809 0.000
E66.1 Drug-induced obesity
0.000 0.813 0.187
E23.0 Hypopituitarism
0.000 0.821 0.179
E23.2 Diabetes insipidus
0.000 0.821 0.179
E23.6 Other disorders of pituitary gland
0.000 0.823 0.177
T42.0 Hydantoin derivatives
0.171 0.829 0.000
E24.8 Other Cushing's syndrome
0.001 0.834 0.165
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.001 0.834 0.165
E24.3 Ectopic ACTH syndrome
0.001 0.834 0.165
E24.1 Nelson's syndrome
0.001 0.834 0.165
L41.9 Parapsoriasis, unspecified
0.166 0.834 0.000
L41.8 Other parapsoriasis
0.166 0.834 0.000
L41.5 Retiform parapsoriasis
0.166 0.834 0.000
L41.4 Large plaque parapsoriasis
0.166 0.834 0.000
L41.3 Small plaque parapsoriasis
0.166 0.834 0.000
L41.2 Lymphomatoid papulosis
0.166 0.834 0.000
L41.1 Pityriasis lichenoides chronica
0.166 0.834 0.000
L41.0 Pityriasis lichenoides et varioliformis acuta
0.166 0.834 0.000
L44.9 Papulosquamous disorder, unspecified
0.166 0.834 0.000
L44.8 Other specified papulosquamous disorders
0.166 0.834 0.000
L44.4 Infantile papular acrodermatitis [Giannotti-Crosti]
0.166 0.834 0.000
L44.3 Lichen ruber moniliformis
0.166 0.834 0.000
L44.2 Lichen striatus
0.166 0.834 0.000
L44.1 Lichen nitidus
0.166 0.834 0.000
L44.0 Pityriasis rubra pilaris
0.166 0.834 0.000
E66.0 Obesity due to excess calories
0.000 0.836 0.164
E29.1 Testicular hypofunction
0.000 0.837 0.163
T39.0 Salicylates
0.163 0.837 0.000
T42.4 Benzodiazepines
0.158 0.842 0.000
T39.9 Nonopioid analgesic, antipyretic and antirheumatic, unspecified
0.155 0.845 0.000
M35.0 Sicca syndrome [Sjogren]
0.000 0.846 0.154
E66.2 Extreme obesity with alveolar hypoventilation
0.000 0.848 0.152
E24.2 Drug-induced Cushing's syndrome
0.001 0.856 0.143
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]
0.139 0.861 0.000
T39.4 Antirheumatics, not elsewhere classified
0.137 0.863 0.000
T39.2 Pyrazolone derivatives
0.137 0.863 0.000
L43 Lichen planus
0.124 0.876 0.000
E24.0 Pituitary-dependent Cushing's disease
0.001 0.878 0.122
M35 Other systemic involvement of connective tissue
0.000 0.880 0.120
T39.1 4-Aminophenol derivatives
0.117 0.883 0.000
T45.5 Anticoagulants
0.111 0.888 0.001
E24.9 Cushing's syndrome, unspecified
0.001 0.889 0.111
T40.5 Cocaine
0.107 0.892 0.000
M35.3 Polymyalgia rheumatica
0.000 0.893 0.107
M35.1 Other overlap syndromes
0.000 0.900 0.100
T40.9 Other and unspecified psychodysleptics [hallucinogens]
0.100 0.900 0.000
T40.8 Lysergide [LSD]
0.100 0.900 0.000
T40.7 Cannabis (derivatives)
0.100 0.900 0.000
T40.3 Methadone
0.100 0.900 0.000
T40.1 Heroin
0.100 0.900 0.000
T40.0 Opium
0.100 0.900 0.000
M35.7 Hypermobility syndrome
0.000 0.904 0.096
E70-E90 Metabolic disorders
0.000 0.905 0.095
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.906 0.094
M06.9 Rheumatoid arthritis, unspecified
0.000 0.909 0.091
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.910 0.089
L43.3 Subacute (active) lichen planus
0.089 0.911 0.000
L43.2 Lichenoid drug reaction
0.089 0.911 0.000
L43.1 Bullous lichen planus
0.089 0.911 0.000
L43.0 Hypertrophic lichen planus
0.089 0.911 0.000
M35.9 Systemic involvement of connective tissue, unspecified
0.000 0.914 0.086
M35.6 Relapsing panniculitis [Weber-Christian]
0.000 0.914 0.086
M35.5 Multifocal fibrosclerosis
0.000 0.914 0.086
M35.4 Diffuse (eosinophilic) fasciitis
0.000 0.914 0.086
M35.2 Behcet's disease
0.000 0.914 0.086
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.915 0.085
E89.0 Postprocedural hypothyroidism
0.000 0.916 0.084
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.000 0.917 0.083
M07.30 Other psoriatic arthropathies (Multiple sites)
0.082 0.918 0.000
E73 Lactose intolerance
0.000 0.918 0.082
E14.9 Without complications
0.000 0.919 0.081
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.920 0.080
M35.8 Other specified systemic involvement of connective tissue
0.000 0.920 0.080
M07.3 Other psoriatic arthropathies
0.080 0.920 0.000
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.921 0.079
T40.4 Other synthetic narcotics
0.078 0.922 0.000
L43.8 Other lichen planus
0.077 0.923 0.000
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.000 0.925 0.075
E88 Other metabolic disorders
0.000 0.926 0.074
T40.6 Other and unspecified narcotics
0.074 0.926 0.000
E73.9 Lactose intolerance, unspecified
0.000 0.927 0.073
M07.39 Other psoriatic arthropathies (Site unspecified)
0.072 0.928 0.000
E84 Cystic fibrosis
0.000 0.929 0.071

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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