TreeWAS – Variant ID: rs12459943

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
# Top node	1.000	0.000	0.000
Chapter IX Diseases of the circulatory system	0.997	0.003	0.000
Chapter V Mental and behavioural disorders	0.992	0.008	0.000
I20-I25 Ischaemic heart diseases	0.989	0.011	0.000
F10-F19 Mental and behavioural disorders due to psychoactive substance use	0.982	0.018	0.000
Chapter II Neoplasms	0.974	0.026	0.000
F10 Mental and behavioural disorders due to use of alcohol	0.972	0.028	0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue	0.971	0.029	0.000
I20 Angina pectoris	0.945	0.055	0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes	0.944	0.056	0.000
I80-I89 Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified	0.944	0.056	0.000
Chapter VII Diseases of the eye and adnexa	0.934	0.066	0.000
I25 Chronic ischaemic heart disease	0.922	0.078	0.000
F10.1 Harmful use	0.909	0.091	0.000
I84 Haemorrhoids	0.905	0.095	0.000
D10-D36 Benign neoplasms	0.895	0.105	0.000
Chapter XV Pregnancy, childbirth and the puerperium	0.894	0.106	0.000
I20.9 Angina pectoris, unspecified	0.880	0.120	0.000
Chapter XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	0.879	0.121	0.000
M45-M49 Spondylopathies	0.870	0.130	0.000
F30-F39 Mood [affective] disorders	0.870	0.130	0.000
I25.2 Old myocardial infarction	0.854	0.146	0.000
F10.2 Dependence syndrome	0.854	0.146	0.000
Chapter XIV Diseases of the genitourinary system	0.851	0.149	0.000
I24 Other acute ischaemic heart diseases	0.850	0.150	0.000
I30-I52 Other forms of heart disease	0.848	0.152	0.000
F10.0 Acute intoxication	0.846	0.154	0.000
I84.9 Unspecified haemorrhoids without complication	0.844	0.156	0.000
C43-C44 Melanoma and other malignant neoplasms of skin	0.842	0.158	0.000
S00-S09 Injuries to the head	0.841	0.159	0.000
M20-M25 Other joint disorders	0.839	0.161	0.000
H30-H36 Disorders of choroid and retina	0.836	0.164	0.000
M50-M54 Other dorsopathies	0.824	0.176	0.000
T36-T50 Poisoning by drugs, medicaments and biological substances	0.818	0.182	0.000
I84.8 Unspecified haemorrhoids with other complications	0.818	0.182	0.000
I20.0 Unstable angina	0.816	0.184	0.000
F17 Mental and behavioural disorders due to use of tobacco	0.805	0.195	0.000
M47 Spondylosis	0.798	0.202	0.000
F10.3 Withdrawal state	0.797	0.203	0.000
I25.8 Other forms of chronic ischaemic heart disease	0.796	0.204	0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source	0.790	0.210	0.000
M15-M19 Arthrosis	0.784	0.216	0.000
Chapter IV Endocrine, nutritional and metabolic diseases	0.778	0.222	0.000
C60-C63 Malignant neoplasms of male genital organs	0.771	0.229	0.000
Chapter VI Diseases of the nervous system	0.763	0.237	0.000
N80-N98 Noninflammatory disorders of female genital tract	0.758	0.242	0.000
R20-R23 Symptoms and signs involving the skin and subcutaneous tissue	0.753	0.247	0.000
R00-R09 Symptoms and signs involving the circulatory and respiratory systems	0.748	0.252	0.000
C64-C68 Malignant neoplasms of urinary tract	0.744	0.256	0.000
H49-H52 Disorders of ocular muscles, binocular movement, accommodation and refraction	0.743	0.257	0.000
D25 Leiomyoma of uterus	0.743	0.257	0.000
H53-H54 Visual disturbances and blindness	0.742	0.258	0.000
M20 Acquired deformities of fingers and toes	0.742	0.258	0.000
H35 Other retinal disorders	0.741	0.259	0.000
F32 Depressive episode	0.740	0.260	0.000
C50-C50 Malignant neoplasm of breast	0.733	0.267	0.000
M54 Dorsalgia	0.729	0.271	0.000
S01 Open wound of head	0.729	0.271	0.000
O30-O48 Maternal care related to the fetus and amniotic cavity and possible delivery problems	0.728	0.272	0.000
Chapter XII Diseases of the skin and subcutaneous tissue	0.723	0.277	0.000
Chapter I Certain infectious and parasitic diseases	0.723	0.277	0.000
D22 Melanocytic naevi	0.723	0.277	0.000
N20-N23 Urolithiasis	0.721	0.279	0.000
Chapter XXII Codes for special purposes	0.717	0.283	0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities	0.717	0.283	0.000
Chapter XVI Certain conditions originating in the perinatal period	0.717	0.283	0.000
I24.9 Acute ischaemic heart disease, unspecified	0.716	0.284	0.000
I05-I09 Chronic rheumatic heart diseases	0.715	0.285	0.000
I00-I02 Acute rheumatic fever	0.715	0.285	0.000
I83 Varicose veins of lower extremities	0.715	0.285	0.000
D12 Benign neoplasm of colon, rectum, anus and anal canal	0.715	0.285	0.000
M70-M79 Other soft tissue disorders	0.713	0.287	0.000
F99-F99 Unspecified mental disorder	0.711	0.289	0.000
F90-F98 Behavioural and emotional disorders with onset usually occurring in childhood and adolescence	0.711	0.289	0.000
F80-F89 Disorders of psychological development	0.711	0.289	0.000
F70-F79 Mental retardation	0.711	0.289	0.000
F60-F69 Disorders of adult personality and behaviour	0.711	0.289	0.000
F50-F59 Behavioural syndromes associated with physiological disturbances and physical factors	0.711	0.289	0.000
F20-F29 Schizophrenia, schizotypal and delusional disorders	0.711	0.289	0.000
F00-F09 Organic, including symptomatic, mental disorders	0.711	0.289	0.000
C15-C26 Malignant neoplasms of digestive organs	0.711	0.289	0.000
O10-O16 Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium	0.709	0.290	0.000
I23 Certain current complications following acute myocardial infarction	0.709	0.291	0.000
I22 Subsequent myocardial infarction	0.709	0.291	0.000
I84.2 Internal haemorrhoids without complication	0.709	0.291	0.000
C51-C58 Malignant neoplasms of female genital organs	0.709	0.291	0.000
M47.8 Other spondylosis	0.708	0.292	0.000
C76-C80 Malignant neoplasms of ill-defined, secondary and unspecified sites	0.707	0.293	0.000
F19 Mental and behavioural disorders due to multiple drug use and use of other psychoactive substances	0.704	0.296	0.000
F18 Mental and behavioural disorders due to use of volatile solvents	0.704	0.296	0.000
F16 Mental and behavioural disorders due to use of hallucinogens	0.704	0.296	0.000
F15 Mental and behavioural disorders due to use of other stimulants, including caffeine	0.704	0.296	0.000
F14 Mental and behavioural disorders due to use of cocaine	0.704	0.296	0.000
F13 Mental and behavioural disorders due to use of sedatives or hypnotics	0.704	0.296	0.000
F12 Mental and behavioural disorders due to use of cannabinoids	0.704	0.296	0.000
F11 Mental and behavioural disorders due to use of opioids	0.704	0.296	0.000
F31 Bipolar affective disorder	0.704	0.296	0.000
R50-R69 General symptoms and signs	0.702	0.298	0.000
S00 Superficial injury of head	0.700	0.299	0.000
D37-D48 Neoplasms of uncertain or unknown behaviour	0.699	0.301	0.000
D00-D09 In situ neoplasms	0.699	0.301	0.000
C97-C97 Malignant neoplasms of independent (primary) multiple sites	0.699	0.301	0.000
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue	0.699	0.301	0.000
C73-C75 Malignant neoplasms of thyroid and other endocrine glands	0.699	0.301	0.000
C69-C72 Malignant neoplasms of eye, brain and other parts of central nervous system	0.699	0.301	0.000
C45-C49 Malignant neoplasms of mesothelial and soft tissue	0.699	0.301	0.000
C40-C41 Malignant neoplasms of bone and articular cartilage	0.699	0.301	0.000
C30-C39 Malignant neoplasms of respiratory and intrathoracic organs	0.699	0.301	0.000
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx	0.699	0.301	0.000
F10.9 Unspecified mental and behavioural disorder	0.697	0.303	0.000
F10.8 Other mental and behavioural disorders	0.697	0.303	0.000
F10.7 Residual and late-onset psychotic disorder	0.697	0.303	0.000
F10.6 Amnesic syndrome	0.697	0.303	0.000
F10.5 Psychotic disorder	0.697	0.303	0.000
F10.4 Withdrawal state with delirium	0.697	0.303	0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue	0.696	0.303	0.000
M91-M94 Chondropathies	0.696	0.303	0.000
M86-M90 Other osteopathies	0.696	0.303	0.000
M65-M68 Disorders of synovium and tendon	0.696	0.303	0.000
M60-M63 Disorders of muscles	0.696	0.303	0.000
M40-M43 Deforming dorsopathies	0.696	0.303	0.000
M00-M03 Infectious arthropathies	0.696	0.303	0.000
C44 Other malignant neoplasms of skin	0.696	0.304	0.000
Chapter VIII Diseases of the ear and mastoid process	0.692	0.307	0.000
I95-I99 Other and unspecified disorders of the circulatory system	0.691	0.309	0.000
S70-S79 Injuries to the hip and thigh	0.691	0.309	0.000
C43 Malignant melanoma of skin	0.688	0.312	0.000
I21 Acute myocardial infarction	0.686	0.314	0.000
H00-H06 Disorders of eyelid, lacrimal system and orbit	0.686	0.314	0.000
I60-I69 Cerebrovascular diseases	0.686	0.314	0.000
O20-O29 Other maternal disorders predominantly related to pregnancy	0.682	0.317	0.000
H25-H28 Disorders of lens	0.681	0.319	0.000
O60-O75 Complications of labour and delivery	0.681	0.319	0.000
T51 Toxic effect of alcohol	0.680	0.320	0.000
D18 Haemangioma and lymphangioma, any site	0.680	0.320	0.000
F17.1 Harmful use	0.679	0.321	0.000
I20.8 Other forms of angina pectoris	0.678	0.322	0.000
I20.1 Angina pectoris with documented spasm	0.678	0.322	0.000
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics	0.677	0.323	0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes	0.677	0.323	0.000
T79-T79 Certain early complications of trauma	0.677	0.323	0.000
T66-T78 Other and unspecified effects of external causes	0.677	0.323	0.000
T33-T35 Frostbite	0.677	0.323	0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions	0.677	0.323	0.000
T26-T28 Burns and corrosions confined to eye and internal organs	0.677	0.323	0.000
T20-T25 Burns and corrosions of external body surface, specified by site	0.677	0.323	0.000
T15-T19 Effects of foreign body entering through natural orifice	0.677	0.323	0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region	0.677	0.323	0.000
T00-T07 Injuries involving multiple body regions	0.677	0.323	0.000
S90-S99 Injuries to the ankle and foot	0.677	0.323	0.000
S40-S49 Injuries to the shoulder and upper arm	0.677	0.323	0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis	0.677	0.323	0.000
S20-S29 Injuries to the thorax	0.677	0.323	0.000
S10-S19 Injuries to the neck	0.677	0.323	0.000
I89 Other non-infective disorders of lymphatic vessels and lymph nodes	0.676	0.323	0.000
I88 Nonspecific lymphadenitis	0.676	0.323	0.000
I87 Other disorders of veins	0.676	0.323	0.000
I86 Varicose veins of other sites	0.676	0.323	0.000
I85 Oesophageal varices	0.676	0.323	0.000
I82 Other venous embolism and thrombosis	0.676	0.323	0.000
I81 Portal vein thrombosis	0.676	0.323	0.000
I49 Other cardiac arrhythmias	0.676	0.324	0.000
M80-M85 Disorders of bone density and structure	0.675	0.325	0.000
D23 Other benign neoplasms of skin	0.672	0.328	0.000
O00-O08 Pregnancy with abortive outcome	0.672	0.328	0.000
T43 Poisoning by psychotropic drugs, not elsewhere classified	0.671	0.329	0.000
I24.8 Other forms of acute ischaemic heart disease	0.671	0.329	0.000
H55-H59 Other disorders of eye and adnexa	0.669	0.331	0.000
H46-H48 Disorders of optic nerve and visual pathways	0.669	0.331	0.000
H43-H45 Disorders of vitreous body and globe	0.669	0.331	0.000
H15-H22 Disorders of sclera, cornea, iris and ciliary body	0.669	0.331	0.000
H10-H13 Disorders of conjunctiva	0.669	0.331	0.000
R47-R49 Symptoms and signs involving speech and voice	0.669	0.331	0.000
M47.9 Spondylosis, unspecified	0.668	0.332	0.000
S80-S89 Injuries to the knee and lower leg	0.664	0.336	0.000
I31 Other diseases of pericardium	0.662	0.338	0.000
M05-M14 Inflammatory polyarthropathies	0.662	0.338	0.000
M25 Other joint disorders, not elsewhere classified	0.662	0.338	0.000
I25.6 Silent myocardial ischaemia	0.661	0.339	0.000
I25.5 Ischaemic cardiomyopathy	0.661	0.339	0.000
I25.4 Coronary artery aneurysm	0.661	0.339	0.000
I25.3 Aneurysm of heart	0.661	0.339	0.000
I25.0 Atherosclerotic cardiovascular disease, so described	0.661	0.339	0.000
H33 Retinal detachments and breaks	0.661	0.339	0.000
H40-H42 Glaucoma	0.659	0.341	0.000
I70-I79 Diseases of arteries, arterioles and capillaries	0.658	0.341	0.000
S50-S59 Injuries to the elbow and forearm	0.658	0.342	0.000
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation	0.657	0.343	0.000
H35.3 Degeneration of macula and posterior pole	0.654	0.346	0.000
S60-S69 Injuries to the wrist and hand	0.654	0.346	0.000
R90-R94 Abnormal findings on diagnostic imaging and in function studies, without diagnosis	0.652	0.348	0.000
I34 Nonrheumatic mitral valve disorders	0.651	0.349	0.000
M54.5 Low back pain	0.650	0.350	0.000
I84.7 Unspecified thrombosed haemorrhoids	0.649	0.351	0.000
I84.5 External haemorrhoids without complication	0.649	0.351	0.000
I84.4 External haemorrhoids with other complications	0.649	0.351	0.000
I84.3 External thrombosed haemorrhoids	0.649	0.351	0.000
I84.0 Internal thrombosed haemorrhoids	0.649	0.351	0.000
R55 Syncope and collapse	0.649	0.351	0.000
I51 Complications and ill-defined descriptions of heart disease	0.649	0.351	0.000
M20.1 Hallux valgus (acquired)	0.649	0.351	0.000
N81 Female genital prolapse	0.647	0.353	0.000
F32.9 Depressive episode, unspecified	0.646	0.354	0.000
N10-N16 Renal tubulo-interstitial diseases	0.645	0.355	0.000
R20 Disturbances of skin sensation	0.645	0.355	0.000
D36 Benign neoplasm of other and unspecified sites	0.641	0.358	0.000
D35 Benign neoplasm of other and unspecified endocrine glands	0.641	0.358	0.000
D33 Benign neoplasm of brain and other parts of central nervous system	0.641	0.358	0.000
D32 Benign neoplasm of meninges	0.641	0.358	0.000
D31 Benign neoplasm of eye and adnexa	0.641	0.358	0.000
D30 Benign neoplasm of urinary organs	0.641	0.358	0.000
D29 Benign neoplasm of male genital organs	0.641	0.358	0.000
D28 Benign neoplasm of other and unspecified female genital organs	0.641	0.358	0.000
D26 Other benign neoplasms of uterus	0.641	0.358	0.000
D21 Other benign neoplasms of connective and other soft tissue	0.641	0.358	0.000
D20 Benign neoplasm of soft tissue of retroperitoneum and peritoneum	0.641	0.358	0.000
D19 Benign neoplasm of mesothelial tissue	0.641	0.358	0.000
D16 Benign neoplasm of bone and articular cartilage	0.641	0.358	0.000
D15 Benign neoplasm of other and unspecified intrathoracic organs	0.641	0.358	0.000
D14 Benign neoplasm of middle ear and respiratory system	0.641	0.358	0.000
D13 Benign neoplasm of other and ill-defined parts of digestive system	0.641	0.358	0.000
D11 Benign neoplasm of major salivary glands	0.641	0.358	0.000
D10 Benign neoplasm of mouth and pharynx	0.641	0.358	0.000
D34 Benign neoplasm of thyroid gland	0.641	0.358	0.000
D27 Benign neoplasm of ovary	0.641	0.358	0.000
D24 Benign neoplasm of breast	0.641	0.358	0.000
O94-O99 Other obstetric conditions, not elsewhere classified	0.641	0.359	0.000
O85-O92 Complications predominantly related to the puerperium	0.641	0.359	0.000
O80-O84 Delivery	0.641	0.359	0.000
N25-N29 Other disorders of kidney and ureter	0.640	0.360	0.000
I25.1 Atherosclerotic heart disease	0.639	0.361	0.000
Chapter XI Diseases of the digestive system	0.637	0.363	0.000
I10-I15 Hypertensive diseases	0.636	0.364	0.000
E70-E90 Metabolic disorders	0.633	0.367	0.000
R83-R89 Abnormal findings on examination of other body fluids, substances and tissues, without diagnosis	0.632	0.368	0.000
D17 Benign lipomatous neoplasm	0.631	0.369	0.000
R95-R99 Ill-defined and unknown causes of mortality	0.630	0.370	0.000
R80-R82 Abnormal findings on examination of urine, without diagnosis	0.630	0.370	0.000
I80 Phlebitis and thrombophlebitis	0.630	0.370	0.000
R70-R79 Abnormal findings on examination of blood, without diagnosis	0.630	0.370	0.000
R06 Abnormalities of breathing	0.630	0.370	0.000
R07 Pain in throat and chest	0.629	0.371	0.000
M47.82 Other spondylosis (Cervical region)	0.629	0.371	0.000
R40-R46 Symptoms and signs involving cognition, perception, emotional state and behaviour	0.627	0.373	0.000
C61 Malignant neoplasm of prostate	0.625	0.375	0.000
Chapter XX External causes of morbidity and mortality	0.625	0.375	0.000
N84 Polyp of female genital tract	0.624	0.376	0.000
M49 Spondylopathies in diseases classified elsewhere	0.624	0.376	0.000
M46 Other inflammatory spondylopathies	0.624	0.376	0.000
M45 Ankylosing spondylitis	0.624	0.376	0.000
M48 Other spondylopathies	0.624	0.376	0.000
F38 Other mood [affective] disorders	0.624	0.376	0.000
F34 Persistent mood [affective] disorders	0.624	0.376	0.000
F33 Recurrent depressive disorder	0.624	0.376	0.000
F30 Manic episode	0.624	0.376	0.000
F39 Unspecified mood [affective] disorder	0.624	0.376	0.000
N70-N77 Inflammatory diseases of female pelvic organs	0.624	0.376	0.000
F40-F48 Neurotic, stress-related and somatoform disorders	0.623	0.377	0.000
R25-R29 Symptoms and signs involving the nervous and musculoskeletal systems	0.619	0.381	0.000
M35 Other systemic involvement of connective tissue	0.616	0.384	0.000
N20 Calculus of kidney and ureter	0.615	0.385	0.000
N99-N99 Other disorders of the genitourinary system	0.610	0.389	0.000
N60-N64 Disorders of breast	0.610	0.389	0.000
N00-N08 Glomerular diseases	0.610	0.389	0.000
I24.1 Dressler's syndrome	0.609	0.390	0.000
I24.0 Coronary thrombosis not resulting in myocardial infarction	0.609	0.390	0.000
Chapter XXI Factors influencing health status and contact with health services	0.609	0.391	0.000
I52 Other heart disorders in diseases classified elsewhere	0.608	0.392	0.000
I48 Atrial fibrillation and flutter	0.608	0.392	0.000
I46 Cardiac arrest	0.608	0.392	0.000
I45 Other conduction disorders	0.608	0.392	0.000
I43 Cardiomyopathy in diseases classified elsewhere	0.608	0.392	0.000
I42 Cardiomyopathy	0.608	0.392	0.000
I41 Myocarditis in diseases classified elsewhere	0.608	0.392	0.000
I40 Acute myocarditis	0.608	0.392	0.000
I39 Endocarditis and heart valve disorders in diseases classified elsewhere	0.608	0.392	0.000
I37 Pulmonary valve disorders	0.608	0.392	0.000
I36 Nonrheumatic tricuspid valve disorders	0.608	0.392	0.000
I35 Nonrheumatic aortic valve disorders	0.608	0.392	0.000
I33 Acute and subacute endocarditis	0.608	0.392	0.000
I32 Pericarditis in diseases classified elsewhere	0.608	0.392	0.000
I30 Acute pericarditis	0.608	0.392	0.000
I38 Endocarditis, valve unspecified	0.608	0.392	0.000
S01.0 Open wound of scalp	0.607	0.393	0.000
D25.9 Leiomyoma of uterus, unspecified	0.607	0.393	0.000
H50 Other strabismus	0.607	0.393	0.000
I84.6 Residual haemorrhoidal skin tags	0.607	0.393	0.000
T80-T88 Complications of surgical and medical care, not elsewhere classified	0.606	0.394	0.000
H53 Visual disturbances	0.605	0.395	0.000
M19 Other arthrosis	0.604	0.396	0.000
S08 Traumatic amputation of part of head	0.603	0.397	0.000
S07 Crushing injury of head	0.603	0.397	0.000
S06 Intracranial injury	0.603	0.397	0.000
S05 Injury of eye and orbit	0.603	0.397	0.000
S04 Injury of cranial nerves	0.603	0.397	0.000
S03 Dislocation, sprain and strain of joints and ligaments of head	0.603	0.397	0.000
S02 Fracture of skull and facial bones	0.603	0.397	0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere	0.601	0.399	0.000
M34 Systemic sclerosis	0.601	0.399	0.000
M33 Dermatopolymyositis	0.601	0.399	0.000
M32 Systemic lupus erythematosus	0.601	0.399	0.000
M31 Other necrotising vasculopathies	0.601	0.399	0.000
M30 Polyarteritis nodosa and related conditions	0.601	0.399	0.000
M24 Other specific joint derangements	0.601	0.399	0.000
M22 Disorders of patella	0.601	0.399	0.000
M21 Other acquired deformities of limbs	0.601	0.399	0.000
T51.0 Ethanol	0.601	0.399	0.000
N17-N19 Renal failure	0.601	0.399	0.000
M17 Gonarthrosis [arthrosis of knee]	0.600	0.400	0.000
S00.8 Superficial injury of other parts of head	0.600	0.400	0.000
H36 Retinal disorders in diseases classified elsewhere	0.599	0.401	0.000
H34 Retinal vascular occlusions	0.599	0.401	0.000
H32 Chorioretinal disorders in diseases classified elsewhere	0.599	0.401	0.000
H31 Other disorders of choroid	0.599	0.401	0.000
H30 Chorioretinal inflammation	0.599	0.401	0.000
I50 Heart failure	0.598	0.402	0.000
G40-G47 Episodic and paroxysmal disorders	0.598	0.402	0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion	0.595	0.404	0.000
I47 Paroxysmal tachycardia	0.594	0.406	0.000
S01.8 Open wound of other parts of head	0.594	0.406	0.000
R30-R39 Symptoms and signs involving the urinary system	0.594	0.406	0.000
M20.5 Other deformities of toe(s) (acquired)	0.593	0.407	0.000
N94 Pain and other conditions associated with female genital organs and menstrual cycle	0.592	0.408	0.000
I44 Atrioventricular and left bundle-branch block	0.591	0.409	0.000
M53 Other dorsopathies, not elsewhere classified	0.590	0.409	0.000
M50 Cervical disk disorders	0.590	0.409	0.000
R56 Convulsions, not elsewhere classified	0.590	0.410	0.000
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances	0.587	0.413	0.000
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs	0.587	0.413	0.000
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system	0.587	0.413	0.000
T47 Poisoning by agents primarily affecting gastro-intestinal system	0.587	0.413	0.000
T46 Poisoning by agents primarily affecting the cardiovascular system	0.587	0.413	0.000
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified	0.587	0.413	0.000
T44 Poisoning by drugs primarily affecting the autonomic nervous system	0.587	0.413	0.000
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs	0.587	0.413	0.000
T41 Poisoning by anaesthetics and therapeutic gases	0.587	0.413	0.000
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]	0.587	0.413	0.000
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified	0.587	0.413	0.000
T37 Poisoning by other systemic anti-infectives and antiparasitics	0.587	0.413	0.000
T36 Poisoning by systemic antibiotics	0.587	0.413	0.000
F31.9 Bipolar affective disorder, unspecified	0.586	0.414	0.000
M16 Coxarthrosis [arthrosis of hip]	0.585	0.415	0.000
L80-L99 Other disorders of the skin and subcutaneous tissue	0.584	0.416	0.000
B35-B49 Mycoses	0.581	0.419	0.000
D22.3 Melanocytic naevi of other and unspecified parts of face	0.579	0.421	0.000
C67 Malignant neoplasm of bladder	0.579	0.421	0.000
C43.6 Malignant melanoma of upper limb, including shoulder	0.578	0.422	0.000
F17.9 Unspecified mental and behavioural disorder	0.577	0.422	0.000
F17.8 Other mental and behavioural disorders	0.577	0.422	0.000
F17.7 Residual and late-onset psychotic disorder	0.577	0.422	0.000
F17.6 Amnesic syndrome	0.577	0.422	0.000
F17.5 Psychotic disorder	0.577	0.422	0.000
F17.4 Withdrawal state with delirium	0.577	0.422	0.000
F17.3 Withdrawal state	0.577	0.422	0.000
F17.2 Dependence syndrome	0.577	0.422	0.000
F17.0 Acute intoxication	0.577	0.422	0.000
O16 Unspecified maternal hypertension	0.577	0.423	0.000
R21 Rash and other nonspecific skin eruption	0.576	0.424	0.000
H35.8 Other specified retinal disorders	0.576	0.424	0.000
N80 Endometriosis	0.575	0.425	0.000
R51 Headache	0.575	0.425	0.000
S09 Other and unspecified injuries of head	0.575	0.425	0.000
D25.1 Intramural leiomyoma of uterus	0.574	0.426	0.000
M47.96 Spondylosis, unspecified (Lumbar region)	0.574	0.426	0.000
O32 Maternal care for known or suspected malpresentation of foetus	0.573	0.427	0.000
M47.2 Other spondylosis with radiculopathy	0.572	0.428	0.000
M47.1 Other spondylosis with myelopathy	0.572	0.428	0.000
M47.0 Anterior spinal and vertebral artery compression syndromes	0.572	0.428	0.000
R06.5 Mouth breathing	0.570	0.430	0.000
M75 Shoulder lesions	0.570	0.430	0.000
N92 Excessive, frequent and irregular menstruation	0.570	0.430	0.000
M54.56 Low back pain (Lumbar region)	0.568	0.431	0.000
O48 Prolonged pregnancy	0.568	0.432	0.000
T65 Toxic effect of other and unspecified substances	0.566	0.433	0.000
T63 Toxic effect of contact with venomous animals	0.566	0.433	0.000
T62 Toxic effect of other noxious substances eaten as food	0.566	0.433	0.000
T61 Toxic effect of noxious substances eaten as seafood	0.566	0.433	0.000
T60 Toxic effect of pesticides	0.566	0.433	0.000
T59 Toxic effect of other gases, fumes and vapours	0.566	0.433	0.000
T57 Toxic effect of other inorganic substances	0.566	0.433	0.000
T56 Toxic effect of metals	0.566	0.433	0.000
T54 Toxic effect of corrosive substances	0.566	0.433	0.000
T53 Toxic effect of halogen derivatives of aliphatic and aromatic hydrocarbone	0.566	0.433	0.000
T52 Toxic effect of organic solvents	0.566	0.433	0.000
T64 Toxic effect of aflatoxin and other mycotoxin food contaminants	0.566	0.433	0.000
T58 Toxic effect of carbon monoxide	0.566	0.433	0.000
T55 Toxic effect of soaps and detergents	0.566	0.433	0.000
T43.2 Other and unspecified antidepressants	0.565	0.435	0.000
I25.9 Chronic ischaemic heart disease, unspecified	0.565	0.435	0.000
H25 Senile cataract	0.564	0.436	0.000
E65-E68 Obesity and other hyperalimentation	0.563	0.437	0.000
M18 Arthrosis of first carpometacarpal joint	0.562	0.438	0.000
M15 Polyarthrosis	0.562	0.438	0.000
M51 Other intervertebral disk disorders	0.561	0.438	0.000
C50 Malignant neoplasm of breast	0.560	0.439	0.000
E50-E64 Other nutritional deficiencies	0.558	0.442	0.000
E40-E46 Malnutrition	0.558	0.442	0.000
E20-E35 Disorders of other endocrine glands	0.558	0.442	0.000
T39.3 Other nonsteroidal anti-inflammatory drugs [NSAID]	0.556	0.444	0.000
K50-K52 Noninfective enteritis and colitis	0.554	0.446	0.000
M54.9 Dorsalgia, unspecified	0.554	0.446	0.000
I49.9 Cardiac arrhythmia, unspecified	0.553	0.447	0.000
C63 Malignant neoplasm of other and unspecified male genital organs	0.553	0.447	0.000
C62 Malignant neoplasm of testis	0.553	0.447	0.000
C60 Malignant neoplasm of penis	0.553	0.447	0.000
R20.8 Other and unspecified disturbances of skin sensation	0.552	0.448	0.000
D12.5 Sigmoid colon	0.552	0.448	0.000
I83.9 Varicose veins of lower extremities without ulcer or inflammation	0.551	0.449	0.000
G50-G59 Nerve, nerve root and plexus disorders	0.549	0.451	0.000
R04 Haemorrhage from respiratory passages	0.548	0.452	0.000
C44.3 Skin of other and unspecified parts of face	0.548	0.452	0.000
D22.5 Melanocytic naevi of trunk	0.547	0.452	0.000
G90-G99 Other disorders of the nervous system	0.547	0.453	0.000
G70-G73 Diseases of myoneural junction and muscle	0.547	0.453	0.000
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system	0.547	0.453	0.000
G35-G37 Demyelinating diseases of the central nervous system	0.547	0.453	0.000
G30-G32 Other degenerative diseases of the nervous system	0.547	0.453	0.000
G20-G26 Extrapyramidal and movement disorders	0.547	0.453	0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system	0.547	0.453	0.000
G00-G09 Inflammatory diseases of the central nervous system	0.547	0.453	0.000
M47.86 Other spondylosis (Lumbar region)	0.545	0.455	0.000
C77 Secondary and unspecified malignant neoplasm of lymph nodes	0.545	0.455	0.000
C44.2 Skin of ear and external auricular canal	0.544	0.456	0.000
N98 Complications associated with artificial fertilisation	0.544	0.456	0.000
N97 Female infertility	0.544	0.456	0.000
N91 Absent, scanty and rare menstruation	0.544	0.456	0.000
N90 Other noninflammatory disorders of vulva and perineum	0.544	0.456	0.000
N89 Other noninflammatory disorders of vagina	0.544	0.456	0.000
N88 Other noninflammatory disorders of cervix uteri	0.544	0.456	0.000
N87 Dysplasia of cervix uteri	0.544	0.456	0.000
N82 Fistulae involving female genital tract	0.544	0.456	0.000
N96 Habitual aborter	0.544	0.456	0.000
N86 Erosion and ectropion of cervix uteri	0.544	0.456	0.000
N23 Unspecified renal colic	0.540	0.460	0.000
R23 Other skin changes	0.540	0.460	0.000
R22 Localised swelling, mass and lump of skin and subcutaneous tissue	0.540	0.460	0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	0.540	0.460	0.001
G80-G83 Cerebral palsy and other paralytic syndromes	0.538	0.462	0.000
R09 Other symptoms and signs involving the circulatory and respiratory systems	0.536	0.463	0.000
R01 Cardiac murmurs and other cardiac sounds	0.536	0.463	0.000
R02 Gangrene, not elsewhere classified	0.536	0.463	0.000
C18 Malignant neoplasm of colon	0.536	0.464	0.000
N93 Other abnormal uterine and vaginal bleeding	0.536	0.464	0.000
I21.0 Acute transmural myocardial infarction of anterior wall	0.535	0.464	0.000
K55-K64 Other diseases of intestines	0.535	0.465	0.000
C68 Malignant neoplasm of other and unspecified urinary organs	0.533	0.466	0.000
C66 Malignant neoplasm of ureter	0.533	0.466	0.000
C65 Malignant neoplasm of renal pelvis	0.533	0.466	0.000
C64 Malignant neoplasm of kidney, except renal pelvis	0.533	0.466	0.000
D12.2 Ascending colon	0.533	0.466	0.000
L55-L59 Radiation-related disorders of the skin and subcutaneous tissue	0.533	0.467	0.000
H52 Disorders of refraction and accommodation	0.533	0.467	0.000
H51 Other disorders of binocular movement	0.533	0.467	0.000
H49 Paralytic strabismus	0.533	0.467	0.000
D25.2 Subserosal leiomyoma of uterus	0.533	0.467	0.000
D25.0 Submucous leiomyoma of uterus	0.533	0.467	0.000
M20.2 Hallux rigidus	0.532	0.467	0.000
H54 Blindness and low vision	0.532	0.468	0.000
M20.6 Acquired deformity of toe(s), unspecified	0.532	0.468	0.000
M20.3 Other deformity of hallux (acquired)	0.532	0.468	0.000
M20.0 Deformity of finger(s)	0.532	0.468	0.000
H35.9 Retinal disorder, unspecified	0.531	0.469	0.000
H35.7 Separation of retinal layers	0.531	0.469	0.000
H35.6 Retinal haemorrhage	0.531	0.469	0.000
H35.5 Hereditary retinal dystrophy	0.531	0.469	0.000
H35.4 Peripheral retinal degeneration	0.531	0.469	0.000
H35.2 Other proliferative retinopathy	0.531	0.469	0.000
H35.1 Retinopathy of prematurity	0.531	0.469	0.000
H35.0 Background retinopathy and retinal vascular changes	0.531	0.469	0.000
O26 Maternal care for other conditions predominantly related to pregnancy	0.531	0.469	0.000
H02 Other disorders of eyelid	0.530	0.470	0.000
F32.8 Other depressive episodes	0.530	0.470	0.000
F32.3 Severe depressive episode with psychotic symptoms	0.530	0.470	0.000
F32.2 Severe depressive episode without psychotic symptoms	0.530	0.470	0.000
F32.1 Moderate depressive episode	0.530	0.470	0.000
F32.0 Mild depressive episode	0.530	0.470	0.000
N81.2 Incomplete uterovaginal prolapse	0.530	0.470	0.000
I31.3 Pericardial effusion (noninflammatory)	0.529	0.471	0.000
D12.8 Rectum	0.528	0.471	0.000
N81.4 Uterovaginal prolapse, unspecified	0.528	0.471	0.000
I84.1 Internal haemorrhoids with other complications	0.528	0.472	0.000
I21.4 Acute subendocardial myocardial infarction	0.528	0.472	0.000
A00-A09 Intestinal infectious diseases	0.527	0.473	0.000
D18.0 Haemangioma, any site	0.525	0.474	0.000
E10-E14 Diabetes mellitus	0.525	0.475	0.000
R03 Abnormal blood-pressure reading, without diagnosis	0.524	0.476	0.000
N83 Noninflammatory disorders of ovary, Fallopian tube and broad ligament	0.523	0.477	0.000
M54.8 Other dorsalgia	0.523	0.477	0.000
M54.6 Pain in thoracic spine	0.523	0.477	0.000
M54.4 Lumbago with sciatica	0.523	0.477	0.000
M54.3 Sciatica	0.523	0.477	0.000
M54.2 Cervicalgia	0.523	0.477	0.000
M54.1 Radiculopathy	0.523	0.477	0.000
M54.0 Panniculitis affecting regions of neck and back	0.523	0.477	0.000
S01.9 Open wound of head, part unspecified	0.523	0.477	0.000
S01.7 Multiple open wounds of head	0.523	0.477	0.000
S01.5 Open wound of lip and oral cavity	0.523	0.477	0.000
S01.4 Open wound of cheek and temporomandibular area	0.523	0.477	0.000
S01.3 Open wound of ear	0.523	0.477	0.000
S01.2 Open wound of nose	0.523	0.477	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations