TreeWAS – Variant ID: rs12460584

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
M19.96 Arthrosis, unspecified-Lower leg	0.105	0.895	0.000
M21.37 Wrist or foot drop (acquired) (Ankle and foot)	0.000	0.942	0.058
M21.3 Wrist or foot drop (acquired)	0.000	0.946	0.054
M21 Other acquired deformities of limbs	0.000	0.948	0.052
M21.2 Flexion deformity	0.000	0.951	0.049
M21.1 Varus deformity, not elsewhere classified	0.000	0.952	0.048
M21.0 Valgus deformity, not elsewhere classified	0.000	0.956	0.044
M21.27 Flexion deformity (Ankle and foot)	0.000	0.957	0.043
M21.5 Acquired clawhand, clubhand, clawfoot and clubfoot	0.000	0.958	0.042
M21.16 Varus deformity, not elsewhere classified (Lower leg)	0.000	0.959	0.041
M21.7 Unequal limb length (acquired)	0.000	0.959	0.041
M21.17 Varus deformity, not elsewhere classified (Ankle and foot)	0.000	0.960	0.040
M21.39 Wrist or foot drop (acquired)-Site unspec	0.000	0.961	0.039
M21.38 Wrist or foot drop (acquired)-Other	0.000	0.961	0.039
M21.36 Wrist or foot drop (acquired)-Lower leg	0.000	0.961	0.039
M21.35 Wrist or foot drop (acquired)-Pelvic/thigh	0.000	0.961	0.039
M21.34 Wrist or foot drop (acquired) (Hand)	0.000	0.961	0.039
M21.32 Wrist or foot drop (acquired)-Upper arm	0.000	0.961	0.039
M21.31 Wrist or foot drop (acquired)-Shldr region	0.000	0.961	0.039
M21.30 Wrist or foot drop (acquired) (Multiple sites)	0.000	0.961	0.039
M21.9 Acquired deformity of limb, unspecified	0.000	0.961	0.039
M21.25 Flexion deformity (Pelvic region and thigh)	0.000	0.961	0.039
M21.6 Other acquired deformities of ankle and foot	0.000	0.961	0.039
M21.26 Flexion deformity (Lower leg)	0.000	0.962	0.038
M21.8 Other specified acquired deformities of limbs	0.000	0.962	0.038
M21.33 Wrist or foot drop (acquired) (Forearm)	0.000	0.962	0.038
M21.57 Acquired clawhand, clubhand, clawfoot and clubfoot (Ankle and foot)	0.000	0.963	0.037
M21.24 Flexion deformity (Hand)	0.000	0.963	0.037
M21.07 Valgus deformity, not elsewhere classified (Ankle and foot)	0.000	0.963	0.037
M21.29 Flexion deformity (Site unspecified)	0.000	0.965	0.035
M21.28 Flexion deformity (Other)	0.000	0.965	0.035
M21.23 Flexion deformity (Forearm)	0.000	0.965	0.035
M21.22 Flexion deformity (Upper arm)	0.000	0.965	0.035
M21.21 Flexion deformity (Shoulder region)	0.000	0.965	0.035
M21.20 Flexion deformity (Multiple sites)	0.000	0.965	0.035
M21.19 Varus deformity, not elsewhere classified (Site unspecified)	0.000	0.966	0.034
M21.18 Varus deformity, not elsewhere classified (Other)	0.000	0.966	0.034
M21.15 Varus deformity, not elsewhere classified (Pelvic region and thigh)	0.000	0.966	0.034
M21.14 Varus deformity, not elsewhere classified (Hand)	0.000	0.966	0.034
M21.13 Varus deformity, not elsewhere classified (Forearm)	0.000	0.966	0.034
M21.12 Varus deformity, not elsewhere classified (Upper arm)	0.000	0.966	0.034
M21.11 Varus deformity, not elsewhere classified (Shoulder region)	0.000	0.966	0.034
M21.10 Varus deformity, not elsewhere classified (Multiple sites)	0.000	0.966	0.034
M21.06 Valgus deformity, not elsewhere classified (Lower leg)	0.000	0.967	0.033
M21.75 Unequal limb length (acquired) (Pelvic region and thigh)	0.000	0.968	0.032
M21.09 Valgus deformity, not elsewhere classified (Site unspecified)	0.000	0.968	0.031
M21.08 Valgus deformity, not elsewhere classified (Other)	0.000	0.968	0.031
M21.05 Valgus deformity, not elsewhere classified (Pelvic region and thigh)	0.000	0.968	0.031
M21.04 Valgus deformity, not elsewhere classified (Hand)	0.000	0.968	0.031
M21.03 Valgus deformity, not elsewhere classified (Forearm)	0.000	0.968	0.031
M21.02 Valgus deformity, not elsewhere classified (Upper arm)	0.000	0.968	0.031
M21.01 Valgus deformity, not elsewhere classified (Shoulder region)	0.000	0.968	0.031
M21.00 Valgus deformity, not elsewhere classified (Multiple sites)	0.000	0.968	0.031
M21.76 Unequal limb length (acquired) (Lower leg)	0.000	0.969	0.031
M21.59 Acquired clawhand, clubhand, clawfoot and clubfoot-Site uns	0.000	0.969	0.030
M21.58 Acquired clawhand, clubhand, clawfoot and clubfoot-Other	0.000	0.969	0.030
M21.56 Acquired clawhand, clubhand, clawfoot and clubfoot-Lower le	0.000	0.969	0.030
M21.55 Acquired clawhand, clubhand, clawfoot and clubfoot-Pelvic/t	0.000	0.969	0.030
M21.53 Acquired clawhand, clubhand, clawfoot and clubfoot-Forearm	0.000	0.969	0.030
M21.52 Acquired clawhand, clubhand, clawfoot and clubfoot-Upper ar	0.000	0.969	0.030
M21.51 Acquired clawhand, clubhand, clawfoot and clubfoot-Shldr re	0.000	0.969	0.030
M21.50 Acquired clawhand, clubhand, clawfoot and clubfoot (Multiple sites)	0.000	0.969	0.030
M21.73 Unequal limb length (acquired) (Forearm)	0.000	0.970	0.030
M21.79 Unequal limb length (acquired) (Site unspecified)	0.000	0.970	0.030
M21.78 Unequal limb length (acquired)-Other	0.000	0.970	0.030
M21.77 Unequal limb length (acquired) (Ankle and foot)	0.000	0.970	0.030
M21.74 Unequal limb length (acquired) (Hand)	0.000	0.970	0.030
M21.72 Unequal limb length (acquired) (Upper arm)	0.000	0.970	0.030
M21.71 Unequal limb length (acquired)-Shldr region	0.000	0.970	0.030
M21.70 Unequal limb length (acquired) (Multiple sites)	0.000	0.970	0.030
M21.4 Flat foot [pes planus] (acquired)	0.000	0.971	0.029
M21.94 Acquired deformity of limb, unspecified (Hand)	0.000	0.971	0.029
M21.67 Other acquired deformities of ankle and foot-Ankle/foot	0.000	0.971	0.029
M21.97 Acquired deformity of limb, unspecified (Ankle and foot)	0.000	0.971	0.029
M21.87 Other specified acquired deformities of limbs (Ankle and foot)	0.000	0.971	0.029
M21.85 Other specified acquired deformities of limbs (Pelvic region and thigh)	0.000	0.972	0.028
M21.99 Acquired deformity of limb, unspecified (Site unspecified)	0.000	0.972	0.028
M21.98 Acquired deformity of limb, unspecified-Other	0.000	0.972	0.028
M21.96 Acquired deformity of limb, unspecified (Lower leg)	0.000	0.972	0.028
M21.95 Acquired deformity of limb, unspecified (Pelvic region and thigh)	0.000	0.972	0.028
M21.93 Acquired deformity of limb, unspecified (Forearm)	0.000	0.972	0.028
M21.92 Acquired deformity of limb, unspecified (Upper arm)	0.000	0.972	0.028
M21.91 Acquired deformity of limb, unspecified (Shoulder region)	0.000	0.972	0.028
M21.90 Acquired deformity of limb, unspecified (Multiple sites)	0.000	0.972	0.028
M21.69 Other acquired deformities of ankle and foot-Site unspec	0.000	0.972	0.028
M21.68 Other acquired deformities of ankle and foot-Other	0.000	0.972	0.028
M21.66 Other acquired deformities of ankle and foot-Lower leg	0.000	0.972	0.028
M21.65 Other acquired deformities of ankle and foot-Pelvic/thigh	0.000	0.972	0.028
M21.64 Other acquired deformities of ankle and foot-Hand	0.000	0.972	0.028
M21.63 Other acquired deformities of ankle and foot-Forearm	0.000	0.972	0.028
M21.62 Other acquired deformities of ankle and foot-Upper arm	0.000	0.972	0.028
M21.61 Other acquired deformities of ankle and foot-Shldr region	0.000	0.972	0.028
M21.60 Other acquired deformities of ankle and foot-Mult sites	0.000	0.972	0.028
M21.89 Other specified acquired deformities of limbs (Site unspecified)	0.000	0.972	0.027
M21.88 Other specified acquired deformities of limbs-Other	0.000	0.972	0.027
M21.86 Other specified acquired deformities of limbs (Lower leg)	0.000	0.972	0.027
M21.84 Other specified acquired deformities of limbs (Hand)	0.000	0.972	0.027
M21.82 Other specified acquired deformities of limbs (Upper arm)	0.000	0.972	0.027
M21.81 Other specified acquired deformities of limbs (Shoulder region)	0.000	0.972	0.027
M21.80 Other specified acquired deformities of limbs (Multiple sites)	0.000	0.972	0.027
M21.54 Acquired clawhand, clubhand, clawfoot and clubfoot (Hand)	0.000	0.974	0.025
M21.83 Other specified acquired deformities of limbs (Forearm)	0.000	0.975	0.025
M21.49 Flat foot [pes planus] (acquired)-Site unspec	0.000	0.979	0.021
M21.48 Flat foot [pes planus] (acquired)-Other	0.000	0.979	0.021
M21.46 Flat foot [pes planus] (acquired)-Lower leg	0.000	0.979	0.021
M21.45 Flat foot [pes planus] (acquired)-Pelvic/thigh	0.000	0.979	0.021
M21.44 Flat foot [pes planus] (acquired)-Hand	0.000	0.979	0.021
M21.43 Flat foot [pes planus] (acquired)-Forearm	0.000	0.979	0.021
M21.42 Flat foot [pes planus] (acquired)-Upper arm	0.000	0.979	0.021
M21.41 Flat foot [pes planus] (acquired)-Shldr region	0.000	0.979	0.021
M21.40 Flat foot [pes planus] (acquired)-Mult sites	0.000	0.979	0.021
Y85.0 Sequelae of motor-vehicle accident	0.000	0.983	0.017
Y85 Sequelae of transport accidents	0.000	0.987	0.013
M21.47 Flat foot [pes planus] (acquired)-Ankle/foot	0.001	0.987	0.012
T44.7 Beta-Adrenoreceeptor antagonists, not elsewhere classified	0.013	0.987	0.000
Y85.9 Sequelae of other and unspecified transport accidents	0.000	0.988	0.012
N84.2 Polyp of vagina	0.011	0.989	0.000
M11.26 Other chondrocalcinosis (Lower leg)	0.009	0.991	0.000
K04.7 Periapical abscess without sinus	0.009	0.991	0.000
Y86 Sequelae of other accidents	0.000	0.992	0.008
Y85-Y89 Sequelae of external causes of morbidity and mortality	0.000	0.992	0.008
T44 Poisoning by drugs primarily affecting the autonomic nervous system	0.008	0.992	0.000
Z73.9 Problem related to life-management difficulty, unspecified	0.008	0.992	0.000
N99.4 Postprocedural pelvic peritoneal adhesions	0.008	0.992	0.000
T39.0 Salicylates	0.007	0.993	0.000
T44.6 Alpha-Adrenoreceeptor antagonists, not elsewhere classified	0.007	0.993	0.000
T44.9 Other and unspecified drugs primarily affecting the nervous system	0.007	0.993	0.000
Y87 Sequelae of intentional self-harm, assault and events of undetermined intent	0.000	0.993	0.007
H73.8 Other specified disorders of tympanic membrane	0.000	0.994	0.006
T44.8 Centrally acting and afrenergic-neuron-blocking agents, not elsewhere classified	0.006	0.994	0.000
T44.5 Predominantly Beta-adrenoreceptor agonists, not elsewhere classified	0.006	0.994	0.000
T44.4 Predominantly Alpha-adrenoreceptor agonists, not elsewhere classified	0.006	0.994	0.000
T44.2 Ganglionic blocking drugs, not elsewhere classified	0.006	0.994	0.000
T44.1 Other parasympathomimetics [cholinergics]	0.006	0.994	0.000
T44.0 Anticholinesterase agents	0.006	0.994	0.000
M11.2 Other chondrocalcinosis	0.006	0.994	0.000
Y87.1 Sequelae of assault	0.000	0.994	0.006
Y89 Sequelae of other external causes	0.000	0.995	0.005
T44.3 Other parasympatholytics [anticholinergics and antimuscarines] and spasmolytics, not elsewhere classified	0.005	0.995	0.000
Y87.0 Sequelae of intentional self-harm	0.000	0.995	0.005
Y87.2 Sequelae of events of undetermined intent	0.000	0.995	0.005
M11.21 Other chondrocalcinosis (Shoulder region)	0.005	0.995	0.000
Z73 Problems related to life-management difficulty	0.005	0.995	0.000
L43.9 Lichen planus, unspecified	0.005	0.995	0.000
Y88 Sequelae of surgical and medical care as external cause	0.000	0.995	0.005
M11.29 Other chondrocalcinosis (Site unspecified)	0.004	0.995	0.000
M11.28 Other chondrocalcinosis (Other)	0.004	0.995	0.000
M11.27 Other chondrocalcinosis (Ankle and foot)	0.004	0.995	0.000
M11.25 Other chondrocalcinosis (Pelvic region and thigh)	0.004	0.995	0.000
M11.24 Other chondrocalcinosis (Hand)	0.004	0.995	0.000
M11.23 Other chondrocalcinosis (Forearm)	0.004	0.995	0.000
M11.22 Other chondrocalcinosis (Upper arm)	0.004	0.995	0.000
M11.20 Other chondrocalcinosis (Multiple sites)	0.004	0.995	0.000
T90.2 Sequelae of fracture of skull and facial bones	0.000	0.995	0.005
Z73.3 Stress, not elsewhere classified	0.004	0.996	0.000
Y89.1 Sequelae of war operations	0.000	0.996	0.004
Y89.0 Sequelae of legal intervention	0.000	0.996	0.004
Z73.8 Other problems related to life-management difficulty	0.004	0.996	0.000
I20.1 Angina pectoris with documented spasm	0.000	0.996	0.004
T46.4 Angiotensin-converting-enzyme inhibitors	0.004	0.996	0.000
T90.5 Sequelae of intracranial injury	0.000	0.996	0.004
Y88.1 Sequelae of misadventures to patients during surgical and medical procedures	0.000	0.996	0.004
Z73.5 Social role conflict, not elsewhere classified	0.004	0.996	0.000
Z73.4 Inadequate social skills, not elsewhere classified	0.004	0.996	0.000
Z73.2 Lack of relaxation and leisure	0.004	0.996	0.000
Z73.1 Accentuation of personality traits	0.004	0.996	0.000
Z73.0 Burn-out	0.004	0.996	0.000
U80.8 Agent resistant to other penicillin-related antibiotic	0.000	0.996	0.004
M79.62 Pain in limb (Upper arm)	0.004	0.996	0.000
Y88.2 Sequelae of adverse incidents associated with medical devices in diagnostic and therapeutic use	0.000	0.996	0.003
Y88.0 Sequelae of adverse effects caused by drugs, medicaments and biological substances in therapeutic use	0.000	0.996	0.003
Y89.9 Sequelae of unspecified external cause	0.000	0.997	0.003
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics	0.003	0.997	0.000
T36-T50 Poisoning by drugs, medicaments and biological substances	0.003	0.997	0.000
T90 Sequelae of injuries of head	0.000	0.997	0.003
I49.3 Ventricular premature depolarisation	0.000	0.997	0.003
K07.6 Temporomandibular joint disorders	0.003	0.997	0.000
T46 Poisoning by agents primarily affecting the cardiovascular system	0.003	0.997	0.000
S72.30 Fracture of shaft of femur (closed)	0.003	0.997	0.000
Z12.8 Special screening examination for neoplasm of other sites	0.003	0.997	0.000
Z73.6 Limitation of activities due to disability	0.003	0.997	0.000
T39.9 Nonopioid analgesic, antipyretic and antirheumatic, unspecified	0.003	0.997	0.000
Z50.2 Alcohol rehabilitation	0.000	0.997	0.003
Z52.4 Kidney donor	0.003	0.997	0.000
N99 Postprocedural disorders of genito-urinary system, not elsewhere classified	0.003	0.997	0.000
T37 Poisoning by other systemic anti-infectives and antiparasitics	0.003	0.997	0.000
T90.8 Sequelae of other specified injuries of head	0.000	0.997	0.003
T43 Poisoning by psychotropic drugs, not elsewhere classified	0.003	0.997	0.000
S69.9 Unspecified injury of wrist and hand	0.003	0.997	0.000
T39.4 Antirheumatics, not elsewhere classified	0.003	0.997	0.000
T39.2 Pyrazolone derivatives	0.003	0.997	0.000
T79.8 Other early complications of trauma	0.003	0.997	0.000
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs	0.003	0.997	0.000
T41 Poisoning by anaesthetics and therapeutic gases	0.003	0.997	0.000
S92.51 Fracture of other toe (open)	0.003	0.997	0.000
I49.4 Other and unspecified premature depolarisation	0.000	0.997	0.003
T90.0 Sequelae of superficial injury of head	0.000	0.997	0.003
T93.2 Sequelae of other fractures of lower limb	0.000	0.997	0.003
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system	0.003	0.997	0.000
T43.6 Psychostimulants with abuse potential	0.003	0.997	0.000
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified	0.003	0.997	0.000
T47 Poisoning by agents primarily affecting gastro-intestinal system	0.003	0.997	0.000
L43 Lichen planus	0.003	0.997	0.000
S63.6 Sprain and strain of finger(s)	0.003	0.997	0.000
T39.8 Other nonopioid analgesics and antipyretics, not elsewhere classified	0.003	0.997	0.000
N99.1 Postprocedural urethral stricture	0.003	0.997	0.000
M82.10 Osteoporosis in endocrine disorders (Multiple sites)	0.000	0.997	0.003
T43.5 Other and unspecified antipsychotics and neuroleptics	0.003	0.997	0.000
T43.1 Monoamine-oxidase-inhibitor antidepressants	0.003	0.997	0.000
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]	0.003	0.997	0.000
C14.0 Pharynx, unspecified	0.003	0.997	0.000
N76.4 Abscess of vulva	0.000	0.997	0.003
M11 Other crystal arthropathies	0.002	0.997	0.000
T46.9 Other and unspecified agents primarily affecting the cardiovascular system	0.002	0.997	0.000
T46.8 Antivaricose drugs, including sclerosing agents	0.002	0.997	0.000
T46.7 Peripheral vasodilators	0.002	0.997	0.000
T46.2 Other antidysrhythmic drugs, not elsewhere classified	0.002	0.997	0.000
T46.0 Cardiac-stimulant glycosides and drugs of similar action	0.002	0.997	0.000
N99.9 Postprocedural disorder of genito-urinary system, unspecified	0.002	0.997	0.000
T90.3 Sequelae of injury of cranial nerves	0.000	0.997	0.002
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances	0.002	0.997	0.000
H11.1 Conjunctival degenerations and deposits	0.002	0.998	0.000
T46.6 Antihyperlipidaemic and antiarteriosclerotic drugs	0.002	0.998	0.000
T90.4 Sequelae of injury of eye and orbit	0.000	0.998	0.002
T90.1 Sequelae of open wound of head	0.000	0.998	0.002
O36.0 Maternal care for rhesus isoimmunisation	0.000	0.998	0.002
T47.2 Stimulant laxatives	0.002	0.998	0.000
H73 Other disorders of tympanic membrane	0.000	0.998	0.002
T36 Poisoning by systemic antibiotics	0.002	0.998	0.000
N99.5 Malfunction of external stoma of urinary tract	0.002	0.998	0.000
T40.6 Other and unspecified narcotics	0.002	0.998	0.000
T37.8 Other specified systemic anti-infectives and antiparasitics	0.002	0.998	0.000
L43.8 Other lichen planus	0.002	0.998	0.000
C01 Malignant neoplasm of base of tongue	0.002	0.998	0.000
I49.0 Ventricular fibrillation and flutter	0.000	0.998	0.002
T47.4 Other laxatives	0.002	0.998	0.000
T38.0 Glucocorticoids and synthetic analogues	0.002	0.998	0.000
T46.3 Coronary vasodilators, not elsewhere classified	0.002	0.998	0.000
M82.11 Osteoporosis in endocrine disorders (Shoulder region)	0.000	0.998	0.002
T38.1 Thyroid hormones and substitutes	0.002	0.998	0.000
H16.0 Corneal ulcer	0.000	0.998	0.002
J98.8 Other specified respiratory disorders	0.002	0.998	0.000
T37.9 Systemic anti-infective and antiparasitic, unspecified	0.002	0.998	0.000
T37.5 Antiviral drugs	0.002	0.998	0.000
T37.4 Anthelminthics	0.002	0.998	0.000
T37.3 Other antiprotozoal drugs	0.002	0.998	0.000
T37.2 Antimalarials and drugs acting on other blood protozoa	0.002	0.998	0.000
T37.1 Antimycobacterial drugs	0.002	0.998	0.000
T37.0 Sulphonamides	0.002	0.998	0.000
T38.6 Antigonadotrophins. antioestrogens, antiandrogens, not elsewhere classified	0.002	0.998	0.000
T90.9 Sequelae of unspecified injury of head	0.000	0.998	0.002
T50.4 Drugs affecting uric acid metabolism	0.002	0.998	0.000
T40.3 Methadone	0.002	0.998	0.000
T43.9 Psychotropic drug, unspecified	0.002	0.998	0.000
T43.8 Other psychotropic drugs, not elsewhere classified	0.002	0.998	0.000
T49.0 Local antifungal, anti-infective and anti-inflammatory drugs, not elsewhere classified	0.002	0.998	0.000
N99.2 Postprocedural adhesions of vagina	0.002	0.998	0.000
T41.5 Therapeutic gases	0.002	0.998	0.000
T41.4 Anaesthetic, unspecified	0.002	0.998	0.000
T41.3 Local anaesthetics	0.002	0.998	0.000
T41.2 Other and unspecified general anaesthetics	0.002	0.998	0.000
T41.1 Intravenous anaesthetics	0.002	0.998	0.000
T41.0 Inhaled anaesthetics	0.002	0.998	0.000
T49.9 Topical agent, unspecified	0.002	0.998	0.000
T49.8 Other topical agents	0.002	0.998	0.000
T49.7 Dental drugs, topically applied	0.002	0.998	0.000
T49.6 Otorhinolaryngological drugs and preparations	0.002	0.998	0.000
T49.5 Ophthalmological drugs and preparations	0.002	0.998	0.000
T49.4 Keratolytics, keratoplastics and other hair treatment drugs and preparations	0.002	0.998	0.000
T49.3 Emollients, demulcents and protectants	0.002	0.998	0.000
T49.2 Local astringents and local detergents	0.002	0.998	0.000
T49.1 Antipruritics	0.002	0.998	0.000
T46.5 Other antihypertensive drugs, not elsewhere classified	0.002	0.998	0.000
C14 Malignant neoplasm of other and ill-defined sites in the lip, oral cavity and pharynx	0.002	0.998	0.000
T38.9 Other and unspecified hormone antagonists	0.002	0.998	0.000
T38.7 Androgens and anabolic congeners	0.002	0.998	0.000
T38.5 Other oestrogens and progestogens	0.002	0.998	0.000
T38.4 Oral contraceptives	0.002	0.998	0.000
T38.2 Antithyroid drugs	0.002	0.998	0.000
T48.7 Other and unspecified agents primarily acting on the respiratory system	0.002	0.998	0.000
T48.5 Anti-common-cold drugs	0.002	0.998	0.000
T48.4 Expectorants	0.002	0.998	0.000
T48.3 Antitussives	0.002	0.998	0.000
T48.2 Other and unspecified agents primarily acting on muscles	0.002	0.998	0.000
T48.1 Skeletal muscle relaxants [neuromuscular blocking agents]	0.002	0.998	0.000
T48.0 Oxytocic drugs	0.002	0.998	0.000
H18 Other disorders of cornea	0.000	0.998	0.002
T43.4 Butyrophenone and thioxanthene neuroleptics	0.002	0.998	0.000
T47.9 Agent primarily affecting the gastro-intestinal system, unspecified	0.002	0.998	0.000
T47.8 Other agents primarily affecting the gastro-intestinal system	0.002	0.998	0.000
T47.7 Emetics	0.002	0.998	0.000
T47.6 Antidiarrhoeal drugs	0.002	0.998	0.000
T47.5 Digestants	0.002	0.998	0.000
T47.3 Saline and osmotic laxatives	0.002	0.998	0.000
I49 Other cardiac arrhythmias	0.000	0.998	0.002
H18.9 Disorder of cornea, unspecified	0.000	0.998	0.002
L43.3 Subacute (active) lichen planus	0.002	0.998	0.000
L43.2 Lichenoid drug reaction	0.002	0.998	0.000
L43.1 Bullous lichen planus	0.002	0.998	0.000
L43.0 Hypertrophic lichen planus	0.002	0.998	0.000
O34.2 Maternal care due to uterine scar from previous surgery	0.002	0.998	0.000
T48.6 Antiasthmatics, not elsewhere classified	0.002	0.998	0.000
C02 Malignant neoplasm of other and unspecified parts of tongue	0.002	0.998	0.000
M82.1 Osteoporosis in endocrine disorders	0.000	0.998	0.002
S92.5 Fracture of other toe	0.002	0.998	0.000
C02.1 Border of tongue	0.002	0.998	0.000
H74.0 Tympanosclerosis	0.000	0.998	0.002
T40.9 Other and unspecified psychodysleptics [hallucinogens]	0.002	0.998	0.000
T40.8 Lysergide [LSD]	0.002	0.998	0.000
T40.7 Cannabis (derivatives)	0.002	0.998	0.000
T40.1 Heroin	0.002	0.998	0.000
T40.0 Opium	0.002	0.998	0.000
T36.3 Macrolides	0.002	0.998	0.000
T50.2 Carbonic-anhydrase inhibitors, benzothiadiazides and other diuretics	0.002	0.998	0.000
Z52.0 Blood donor	0.002	0.998	0.000
S92.50 Fracture of other toe (closed)	0.002	0.998	0.000
M11.1 Familial chondrocalcinosis	0.002	0.998	0.000
M11.0 Hydroxyapatite deposition disease	0.002	0.998	0.000
M11.9 Crystal arthropathy, unspecified	0.002	0.998	0.000
T82.8 Other complications of cardiac and vascular prosthetic devices, implants and grafts	0.000	0.998	0.002
E83.3 Disorders of phosphorus metabolism	0.000	0.998	0.002
H18.8 Other specified disorders of cornea	0.000	0.998	0.002
H18.6 Keratoconus	0.000	0.998	0.002
H18.3 Changes in corneal membranes	0.000	0.998	0.002
T38.8 Other and unspecified hormones and their synthetic substitutes	0.002	0.998	0.000
T50.7 Analeptics and opioid receptor antagonists	0.002	0.998	0.000
T50.5 Appetite depressants	0.002	0.998	0.000
T50.3 Electrolytic, caloric and water-balance agents	0.002	0.998	0.000
T50.1 Loop [high-ceiling] diuretics	0.002	0.998	0.000
T50.0 Mineralocorticoids and their antagonists	0.002	0.998	0.000
K73.9 Chronic hepatitis, unspecified	0.002	0.998	0.000
T40.4 Other synthetic narcotics	0.002	0.998	0.000
T50.8 Diagnostic agents	0.002	0.998	0.000
C02.9 Tongue, unspecified	0.002	0.998	0.000
H73.1 Chronic myringitis	0.000	0.998	0.002
T36.9 Systemic antibiotic, unspecified	0.002	0.998	0.000
T36.8 Other systemic antibiotics	0.002	0.998	0.000
T36.7 Antifungal antibiotics, systemically used	0.002	0.998	0.000
T36.6 Rifamycins	0.002	0.998	0.000
T36.5 Aminoglycosides	0.002	0.998	0.000
T36.4 Tetracyclines	0.002	0.998	0.000
T36.2 Chloramphenicol group	0.002	0.998	0.000
T36.1 Cefalosporins and other Beta-lactam antibiotics	0.002	0.998	0.000
T40.5 Cocaine	0.002	0.998	0.000
Z52 Donors of organs and tissues	0.002	0.998	0.000
H18.2 Other corneal oedema	0.000	0.998	0.002
T47.0 Histamine H(2)-receptor antagonists	0.002	0.998	0.000
T93.8 Sequelae of other specified injuries of lower limb	0.000	0.998	0.002
I49.1 Atrial premature depolarisation	0.000	0.998	0.002
T43.3 Phenothiazine antipsychotics and neuroleptics	0.002	0.998	0.000
M11.8 Other specified crystal arthropathies	0.002	0.998	0.000
C06 Malignant neoplasm of other and unspecified parts of mouth	0.002	0.998	0.000
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx	0.002	0.998	0.000
C02.2 Ventral surface of tongue	0.002	0.998	0.000
C06.2 Retromolar area	0.002	0.998	0.000
H73.9 Disorder of tympanic membrane, unspecified	0.000	0.998	0.002
N99.8 Other postprocedural disorders of genito-urinary system	0.002	0.998	0.000
T50.6 Antidotes and chelating agents, not elsewhere classified	0.002	0.998	0.000
W10.4 Street and highway	0.002	0.998	0.000
S72.3 Fracture of shaft of femur	0.002	0.998	0.000
C06.0 Cheek mucosa	0.002	0.998	0.000
T42.6 Other antiepileptic and sedative-hypnotic drugs	0.002	0.998	0.000
Z52.3 Bone marrow donor	0.002	0.998	0.000
C03.1 Lower gum	0.002	0.998	0.000
H18.4 Corneal degeneration	0.000	0.998	0.002
C03 Malignant neoplasm of gum	0.002	0.998	0.000
R53 Malaise and fatigue	0.000	0.998	0.002
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified	0.001	0.998	0.001
C14.8 Overlapping lesion of lip, oral cavity and pharynx	0.002	0.998	0.000
C14.2 Waldeyer's ring	0.002	0.998	0.000
D30.3 Bladder	0.002	0.998	0.000
N80.9 Endometriosis, unspecified	0.000	0.998	0.002
T93.5 Sequelae of injury of muscle and tendon of lower limb	0.000	0.998	0.002
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs	0.002	0.998	0.000
H18.7 Other corneal deformities	0.000	0.998	0.002
H18.0 Corneal pigmentations and deposits	0.000	0.998	0.002
T98.3 Sequelae of complications of surgical and medical care, not elsewhere classified	0.000	0.998	0.002
H73.0 Acute myringitis	0.000	0.998	0.002
I49.2 Junctional premature depolarisation	0.000	0.998	0.002
C02.8 Overlapping lesion of tongue	0.002	0.998	0.000
C02.3 Anterior two-thirds of tongue, part unspecified	0.002	0.998	0.000
C02.0 Dorsal surface of tongue	0.002	0.998	0.000
C26.0 Intestinal tract, part unspecified	0.000	0.998	0.002
M82.19 Osteoporosis in endocrine disorders (Site unspecified)	0.000	0.998	0.002
M82.18 Osteoporosis in endocrine disorders (Other)	0.000	0.998	0.002
M82.17 Osteoporosis in endocrine disorders (Ankle and foot)	0.000	0.998	0.002
M82.16 Osteoporosis in endocrine disorders (Lower leg)	0.000	0.998	0.002
M82.15 Osteoporosis in endocrine disorders (Pelvic region and thigh)	0.000	0.998	0.002
M82.14 Osteoporosis in endocrine disorders (Hand)	0.000	0.998	0.002
M82.13 Osteoporosis in endocrine disorders (Forearm)	0.000	0.998	0.002
M82.12 Osteoporosis in endocrine disorders (Upper arm)	0.000	0.998	0.002
H74.9 Disorder of middle ear and mastoid, unspecified	0.000	0.998	0.002
T45.5 Anticoagulants	0.000	0.998	0.001
T46.1 Calcium-channel blockers	0.001	0.998	0.000
M11.09 Hydroxyapatite deposition disease (Site unspecified)	0.002	0.998	0.000
M11.08 Hydroxyapatite deposition disease (Other)	0.002	0.998	0.000
M11.07 Hydroxyapatite deposition disease (Ankle and foot)	0.002	0.998	0.000
M11.06 Hydroxyapatite deposition disease (Lower leg)	0.002	0.998	0.000
M11.05 Hydroxyapatite deposition disease (Pelvic region and thigh)	0.002	0.998	0.000
M11.04 Hydroxyapatite deposition disease (Hand)	0.002	0.998	0.000
M11.03 Hydroxyapatite deposition disease (Forearm)	0.002	0.998	0.000
M11.02 Hydroxyapatite deposition disease (Upper arm)	0.002	0.998	0.000
M11.01 Hydroxyapatite deposition disease (Shoulder region)	0.002	0.998	0.000
M11.00 Hydroxyapatite deposition disease (Multiple sites)	0.002	0.998	0.000
M11.19 Familial chondrocalcinosis (Site unspecified)	0.002	0.998	0.000
M11.18 Familial chondrocalcinosis (Other)	0.002	0.998	0.000
M11.17 Familial chondrocalcinosis (Ankle and foot)	0.002	0.998	0.000
M11.16 Familial chondrocalcinosis (Lower leg)	0.002	0.998	0.000
M11.15 Familial chondrocalcinosis (Pelvic region and thigh)	0.002	0.998	0.000
M11.14 Familial chondrocalcinosis (Hand)	0.002	0.998	0.000
M11.13 Familial chondrocalcinosis (Forearm)	0.002	0.998	0.000
M11.12 Familial chondrocalcinosis (Upper arm)	0.002	0.998	0.000
M11.11 Familial chondrocalcinosis (Shoulder region)	0.002	0.998	0.000
M11.10 Familial chondrocalcinosis (Multiple sites)	0.002	0.998	0.000
M11.99 Crystal arthropathy, unspecified (Site unspecified)	0.002	0.998	0.000
M11.98 Crystal arthropathy, unspecified (Other)	0.002	0.998	0.000
M11.97 Crystal arthropathy, unspecified (Ankle and foot)	0.002	0.998	0.000
M11.95 Crystal arthropathy, unspecified (Pelvic region and thigh)	0.002	0.998	0.000
M11.94 Crystal arthropathy, unspecified (Hand)	0.002	0.998	0.000
M11.93 Crystal arthropathy, unspecified (Forearm)	0.002	0.998	0.000
M11.92 Crystal arthropathy, unspecified (Upper arm)	0.002	0.998	0.000
M11.91 Crystal arthropathy, unspecified (Shoulder region)	0.002	0.998	0.000
M11.90 Crystal arthropathy, unspecified (Multiple sites)	0.002	0.998	0.000
T47.1 Other antacids and anti-gastric-secretion drugs	0.002	0.998	0.000
Y88.3 Sequelae of surgical and medical procedures as the cause of abnormal reaction of the patient or of later complication, without mention of misadventure at the time of the procedure	0.000	0.998	0.001
C02.4 Lingual tonsil	0.002	0.998	0.000
N99.0 Postprocedural renal failure	0.002	0.998	0.000
T38.3 Insulin and oral hypoglycaemic [antidiabetic] drugs	0.002	0.998	0.000
T93 Sequelae of injuries of lower limb	0.000	0.998	0.002
M11.96 Crystal arthropathy, unspecified (Lower leg)	0.002	0.998	0.000
S72.31 Fracture of shaft of femur (open)	0.002	0.998	0.000
G25.8 Other specified extrapyramidal and movement disorders	0.000	0.998	0.002
K07.1 Anomalies of jaw-cranial base relationship	0.002	0.998	0.000
C04 Malignant neoplasm of floor of mouth	0.002	0.998	0.000
H16 Keratitis	0.000	0.998	0.002
K07 Dentofacial anomalies [including malocclusion]	0.002	0.998	0.000
T98 Sequelae of other and unspecified effects of external causes	0.000	0.998	0.002
Z52.9 Donor of unspecified organ or tissue	0.002	0.998	0.000
Z52.7 Heart donor	0.002	0.998	0.000
Z52.6 Liver donor	0.002	0.998	0.000
Z52.5 Cornea donor	0.002	0.998	0.000
Z52.1 Skin donor	0.002	0.998	0.000
C00 Malignant neoplasm of lip	0.002	0.998	0.000
H74 Other disorders of middle ear and mastoid	0.000	0.998	0.002
H20.8 Other iridocyclitis	0.000	0.998	0.002
T42.1 Iminostilbenes	0.002	0.998	0.000
R14 Flatulence and related conditions	0.000	0.998	0.002
M11.89 Other specified crystal arthropathies (Site unspecified)	0.001	0.998	0.000
M11.88 Other specified crystal arthropathies (Other)	0.001	0.998	0.000
M11.87 Other specified crystal arthropathies (Ankle and foot)	0.001	0.998	0.000
M11.85 Other specified crystal arthropathies (Pelvic region and thigh)	0.001	0.998	0.000
M11.84 Other specified crystal arthropathies (Hand)	0.001	0.998	0.000
M11.83 Other specified crystal arthropathies (Forearm)	0.001	0.998	0.000
M11.82 Other specified crystal arthropathies (Upper arm)	0.001	0.998	0.000
M11.81 Other specified crystal arthropathies (Shoulder region)	0.001	0.998	0.000
M11.80 Other specified crystal arthropathies (Multiple sites)	0.001	0.998	0.000
C06.8 Overlapping lesion of other and unspecified parts of mouth	0.002	0.998	0.000
C06.1 Vestibule of mouth	0.002	0.998	0.000
H17.9 Corneal scar and opacity, unspecified	0.000	0.998	0.002
Z52.2 Bone donor	0.002	0.998	0.000
C13 Malignant neoplasm of hypopharynx	0.002	0.998	0.000
C09 Malignant neoplasm of tonsil	0.002	0.998	0.000
D62 Acute posthaemorrhagic anaemia	0.000	0.998	0.002
H18.1 Bullous keratopathy	0.000	0.998	0.002
W08.0 Home	0.000	0.998	0.002
C10 Malignant neoplasm of oropharynx	0.002	0.998	0.000
M19.09 Primary arthrosis of other joints (Site unspecified)	0.000	0.998	0.002
D41.4 Bladder	0.002	0.998	0.000
K52.0 Gastro-enteritis and colitis due to radiation	0.000	0.998	0.002
H74.8 Other specified disorders of middle ear and mastoid	0.000	0.998	0.002
T42.8 Anti-Parkinsonism drugs and other central muscle-tone depressants	0.002	0.998	0.000
C00.9 Lip, unspecified	0.002	0.998	0.000
C03.9 Gum, unspecified	0.001	0.998	0.000
H16.3 Interstitial and deep keratitis	0.000	0.998	0.002
T42.5 Mixed antiepileptics, not elsewhere classified	0.001	0.998	0.000
T42.3 Barbiturates	0.001	0.998	0.000
T42.2 Succinimides and oxazolidinediones	0.001	0.998	0.000
T45.9 Primarily systemic and haematological agent, unspecified	0.001	0.998	0.001
T45.8 Other primarily systemic and haematological agents	0.001	0.998	0.001
T45.7 Anticoagulant antagonists, vitamin K and other coagulants	0.001	0.998	0.001
T45.6 Fibrinolysis-affecting drugs	0.001	0.998	0.001
T45.4 Iron and its compounds	0.001	0.998	0.001
T45.3 Enzymes, not elsewhere classified	0.001	0.998	0.001
Z52.8 Donor of other organs and tissues	0.002	0.998	0.000
Z72.1 Alcohol use	0.002	0.998	0.000
C03.0 Upper gum	0.001	0.998	0.000
H05.2 Exophthalmic conditions	0.000	0.998	0.002
H74.2 Discontinuity and dislocation of ear ossicles	0.000	0.998	0.002
H17 Corneal scars and opacities	0.000	0.998	0.002
T36.0 Penicillins	0.001	0.998	0.000
T98.1 Sequelae of other and unspecified effects of external causes	0.000	0.998	0.002
M89.03 Algoneurodystrophy (Forearm)	0.000	0.998	0.002
C18.1 Appendix	0.000	0.998	0.002
X63.0 Home	0.002	0.998	0.000
C08 Malignant neoplasm of other and unspecified major salivary glands	0.001	0.998	0.000
M11.86 Other specified crystal arthropathies (Lower leg)	0.001	0.998	0.000
H16.4 Corneal neovascularisation	0.000	0.998	0.001
K07.3 Anomalies of tooth position	0.002	0.998	0.000
M34.1 CR(E)ST syndrome	0.000	0.998	0.002
C04.9 Floor of mouth, unspecified	0.001	0.998	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations