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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs12529049
log Bayes Factor = 71.2415
Chromosome 6   position 32,357,715  (GRCh37) Explore rs12529049 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
C44.3 Skin of other and unspecified parts of face
1.000 0.000 0.000
E10.9 Without complications
0.000 0.000 1.000
K51.9 Ulcerative colitis, unspecified
1.000 0.000 0.000
K90.0 Coeliac disease
0.000 0.000 1.000
C44 Other malignant neoplasms of skin
1.000 0.000 0.000
K51 Ulcerative colitis
1.000 0.000 0.000
J45.9 Asthma, unspecified
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
C44.7 Skin of lower limb, including hip
0.999 0.001 0.000
K50-K52 Noninfective enteritis and colitis
0.999 0.001 0.000
K50.1 Crohn's disease of large intestine
0.999 0.001 0.000
K50 Crohn's disease [regional enteritis]
0.999 0.001 0.000
Z93.2 Ileostomy status
0.996 0.004 0.000
K51.4 Pseudopolyposis of colon
0.993 0.007 0.000
C44.4 Skin of scalp and neck
0.991 0.009 0.000
E10.1 With ketoacidosis
0.000 0.012 0.988
E10.3 With ophthalmic complications
0.000 0.013 0.987
C44.2 Skin of ear and external auricular canal
0.987 0.013 0.000
C82.9 Follicular non-Hodgkin's lymphoma, unspecified
0.982 0.018 0.000
C82 Follicular [nodular] non-Hodgkin's lymphoma
0.976 0.024 0.000
C44.5 Skin of trunk
0.975 0.025 0.000
C44.6 Skin of upper limb, including shoulder
0.969 0.031 0.000
K51.8 Other ulcerative colitis
0.958 0.042 0.000
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue
0.947 0.053 0.000
K51.2 Ulcerative (chronic) proctitis
0.946 0.054 0.000
C44.0 Skin of lip
0.939 0.061 0.000
C83 Diffuse non-Hodgkin's lymphoma
0.938 0.062 0.000
C83.3 Large cell (diffuse)
0.936 0.064 0.000
D86.9 Sarcoidosis, unspecified
0.000 0.067 0.933
D86 Sarcoidosis
0.000 0.073 0.927
D86.0 Sarcoidosis of lung
0.000 0.081 0.919
C85 Other and unspecified types of non-Hodgkin's lymphoma
0.914 0.086 0.000
K50.9 Crohn's disease, unspecified
0.900 0.100 0.000
C85.9 Non-Hodgkin's lymphoma, unspecified type
0.891 0.109 0.000
C82.0 Small cleaved cell, follicular
0.888 0.112 0.000
E10-E14 Diabetes mellitus
0.000 0.153 0.847
E10.8 With unspecified complications
0.000 0.165 0.835
K52 Other non-infective gastro-enteritis and colitis
0.832 0.168 0.000
K51.5 Mucosal proctocolitis
0.830 0.170 0.000
C82.7 Other types of follicular non-Hodgkin's lymphoma
0.807 0.193 0.000
D51 Vitamin B12 deficiency anaemia
0.000 0.202 0.798
D51.0 Vitamin B12 deficiency anaemia due to intrinsic factor deficiency
0.000 0.203 0.797
D50-D53 Nutritional anaemias
0.000 0.208 0.792
C82.3 Follicular lymphoma grade IIIa
0.791 0.209 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.212 0.788
E16 Other disorders of pancreatic internal secretion
0.000 0.214 0.786
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.214 0.786
E16.2 Hypoglycaemia, unspecified
0.000 0.215 0.785
C44.9 Malignant neoplasm of skin, unspecified
0.784 0.216 0.000
D80-D89 Certain disorders involving the immune mechanism
0.000 0.216 0.784
C44.1 Skin of eyelid, including canthus
0.775 0.225 0.000
E10.0 With coma
0.000 0.233 0.767
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.000 0.239 0.761
E20-E35 Disorders of other endocrine glands
0.000 0.247 0.753
D50 Iron deficiency anaemia
0.000 0.248 0.752
D50.9 Iron deficiency anaemia, unspecified
0.000 0.253 0.747
E10.4 With neurological complications
0.000 0.253 0.747
E10.6 With other specified complications
0.000 0.253 0.747
E27 Other disorders of adrenal gland
0.000 0.256 0.744
D51.9 Vitamin B12 deficiency anaemia, unspecified
0.000 0.257 0.743
K90 Intestinal malabsorption
0.000 0.257 0.743
K52.1 Toxic gastro-enteritis and colitis
0.741 0.259 0.000
E27.1 Primary adrenocortical insufficiency
0.000 0.260 0.740
C83.1 Small cleaved cell (diffuse)
0.727 0.273 0.000
K51.3 Ulcerative (chronic) rectosigmoiditis
0.724 0.276 0.000
K50.8 Other Crohn's disease
0.723 0.277 0.000
C44.8 Overlapping lesion of skin
0.717 0.283 0.000
E10.7 With multiple complications
0.000 0.283 0.717
K51.0 Ulcerative (chronic) enterocolitis
0.714 0.286 0.000
K52.8 Other specified non-infective gastro-enteritis and colitis
0.714 0.286 0.000
C85.1 B-cell lymphoma, unspecified
0.707 0.293 0.000
C43-C44 Melanoma and other malignant neoplasms of skin
0.702 0.298 0.000
C82.6 Cutaneous follicle centre lymphoma
0.700 0.300 0.000
C82.5 Diffuse follicle centre lymphoma
0.700 0.300 0.000
C82.4 Follicular lymphoma grade IIIb
0.700 0.300 0.000
E10.2 With renal complications
0.000 0.303 0.697
C83.9 Diffuse non-Hodgkin's lymphoma, unspecified
0.690 0.310 0.000
E22 Hyperfunction of pituitary gland
0.000 0.311 0.689
K52.3 Indeterminate colitis
0.685 0.315 0.000
C82.2 Large cell, follicular
0.682 0.318 0.000
C81 Hodgkin's disease
0.680 0.320 0.000
C96 Other and unspecified malignant neoplasms of lymphoid, haematopoietic and related tissue
0.679 0.321 0.000
C94 Other leukaemias of specified cell type
0.679 0.321 0.000
C93 Monocytic leukaemia
0.679 0.321 0.000
C86 Other specified types of T/NK-cell lymphoma
0.679 0.321 0.000
C83.6 Undifferentiated (diffuse)
0.672 0.327 0.000
C83.5 Lymphoblastic (diffuse)
0.672 0.327 0.000
C83.4 Immunoblastic (diffuse)
0.672 0.327 0.000
C83.2 Mixed small and large cell (diffuse)
0.672 0.327 0.000
C82.1 Mixed small cleaved and large cell, follicular
0.670 0.330 0.000
D86.8 Sarcoidosis of other and combined sites
0.000 0.335 0.664
D86.3 Sarcoidosis of skin
0.000 0.335 0.664
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes
0.000 0.335 0.664
D86.1 Sarcoidosis of lymph nodes
0.000 0.335 0.664
E13 Other specified diabetes mellitus
0.000 0.338 0.662
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.343 0.657
C85.2 Mediastinal (thymic) large B-cell lymphoma
0.655 0.345 0.000
C85.0 Lymphosarcoma
0.655 0.345 0.000
C83.7 Burkitt's tumour
0.652 0.348 0.000
K51.1 Ulcerative (chronic) ileocolitis
0.647 0.353 0.000
E16.1 Other hypoglycaemia
0.000 0.371 0.629
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.371 0.629
C95 Leukaemia of unspecified cell type
0.626 0.374 0.000
E14 Unspecified diabetes mellitus
0.000 0.378 0.622
E10.5 With peripheral circulatory complications
0.000 0.378 0.622
C84 Peripheral and cutaneous T-cell lymphomas
0.616 0.383 0.000
K52.2 Allergic and dietetic gastro-enteritis and colitis
0.613 0.387 0.000
E12 Malnutrition-related diabetes mellitus
0.000 0.393 0.607
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.396 0.604
C88 Malignant immunoproliferative diseases
0.601 0.398 0.000
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.399 0.601
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.400 0.600
D52 Folate deficiency anaemia
0.000 0.401 0.599
K90.9 Intestinal malabsorption, unspecified
0.000 0.414 0.586
C83.8 Other types of diffuse non-Hodgkin's lymphoma
0.585 0.415 0.000
E27.2 Addisonian crisis
0.000 0.421 0.579
E24 Cushing's syndrome
0.000 0.422 0.578
D51.8 Other vitamin B12 deficiency anaemias
0.000 0.428 0.572
D51.3 Other dietary vitamin B12 deficiency anaemia
0.000 0.428 0.572
D51.2 Transcobalamin II deficiency
0.000 0.428 0.572
D51.1 Vitamin B12 deficiency anaemia due to selective vitamin B12 malabsorption with proteinuria
0.000 0.428 0.572
C85.7 Other specified types of non-Hodgkin's lymphoma
0.568 0.431 0.000
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.436 0.564
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.436 0.564
E16.4 Abnormal secretion of gastrin
0.000 0.436 0.564
E16.3 Increased secretion of glucagon
0.000 0.436 0.564
E15 Nondiabetic hypoglycaemic coma
0.000 0.436 0.564
D82 Immunodeficiency associated with other major defects
0.000 0.438 0.562
D81 Combined immunodeficiencies
0.000 0.438 0.562
K90.8 Other intestinal malabsorption
0.000 0.442 0.558
Chapter II Neoplasms
0.549 0.450 0.000
C73-C75 Malignant neoplasms of thyroid and other endocrine glands
0.547 0.452 0.000
C73 Malignant neoplasm of thyroid gland
0.547 0.453 0.000
D53 Other nutritional anaemias
0.000 0.456 0.544
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.460 0.540
E32 Diseases of thymus
0.000 0.460 0.540
E31 Polyglandular dysfunction
0.000 0.460 0.540
E30 Disorders of puberty, not elsewhere classified
0.000 0.460 0.540
E25 Adrenogenital disorders
0.000 0.460 0.540
D50.1 Sideropenic dysphagia
0.000 0.461 0.539
E20 Hypoparathyroidism
0.000 0.461 0.538
D55-D59 Haemolytic anaemias
0.000 0.463 0.537
E22.0 Acromegaly and pituitary gigantism
0.000 0.464 0.536
E27.5 Adrenomedullary hyperfunction
0.000 0.466 0.533
E27.0 Other adrenocortical overactivity
0.000 0.466 0.533
K90.3 Pancreatic steatorrhoea
0.000 0.467 0.532
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.467 0.532
K90.1 Tropical sprue
0.000 0.467 0.532
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.469 0.531
C81.1 Nodular sclerosis
0.530 0.470 0.000
E13.9 Without complications
0.000 0.470 0.530
E34 Other endocrine disorders
0.000 0.473 0.527
C90 Multiple myeloma and malignant plasma cell neoplasms
0.526 0.474 0.000
E40-E46 Malnutrition
0.000 0.479 0.521
C81.2 Mixed cellularity
0.520 0.479 0.000
C81.0 Lymphocytic predominance
0.516 0.483 0.000
E14.9 Without complications
0.000 0.484 0.516
E21.0 Primary hyperparathyroidism
0.000 0.485 0.515
D83 Common variable immunodeficiency
0.000 0.486 0.514
E65-E68 Obesity and other hyperalimentation
0.000 0.488 0.512
E27.8 Other specified disorders of adrenal gland
0.000 0.496 0.503
E22.1 Hyperprolactinaemia
0.000 0.502 0.498
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.506 0.494
E22.8 Other hyperfunction of pituitary gland
0.000 0.506 0.494
C81.7 Other Hodgkin's disease
0.488 0.512 0.000
C81.4 Lymphocyte-rich classical Hodgkin lymphoma
0.488 0.512 0.000
C81.3 Lymphocytic depletion
0.488 0.512 0.000
C86.6 Primary cutaneous CD30-positive T-cell proliferations
0.487 0.513 0.000
C86.5 Angioimmunoblastic T-cell lymphoma
0.487 0.513 0.000
C86.4 Blastic NK-cell lymphoma
0.487 0.513 0.000
C86.3 Subcutaneous panniculitis-like T-cell lymphoma
0.487 0.513 0.000
C86.2 Enteropathy-type (intestinal) T-cell lymphoma
0.487 0.513 0.000
C86.1 Hepatosplenic T-cell lymphoma
0.487 0.513 0.000
C86.0 Extranodal NK/T-cell lymphoma, nasal type
0.487 0.513 0.000
C93.9 Monocytic leukaemia, unspecified
0.487 0.513 0.000
C93.7 Other monocytic leukaemia
0.487 0.513 0.000
C93.3 Juvenile myelomonocytic leukaemia
0.487 0.513 0.000
C93.2 Subacute monocytic leukaemia
0.487 0.513 0.000
C93.1 Chronic monocytic leukaemia
0.487 0.513 0.000
C93.0 Acute monocytic leukaemia
0.487 0.513 0.000
C94.7 Other specified leukaemias
0.487 0.513 0.000
C94.6 Myelodysplastic and myeloproliferative disease, not elsewhere classified
0.487 0.513 0.000
C94.5 Acute myelofibrosis
0.487 0.513 0.000
C94.4 Acute panmyelosis
0.487 0.513 0.000
C94.3 Mast cell leukaemia
0.487 0.513 0.000
C94.2 Acute megakaryoblastic leukaemia
0.487 0.513 0.000
C94.1 Chronic erythraemia
0.487 0.513 0.000
C94.0 Acute erythraemia and erythroleukaemia
0.487 0.513 0.000
C96.9 Malignant neoplasms of lymphoid, haematopoietic and related tissue, unspecified
0.487 0.513 0.000
C96.8 Histiocytic sarcoma
0.487 0.513 0.000
C96.7 Other specified malignant neoplasms of lymphoid, haematopoietic and related tissue
0.487 0.513 0.000
C96.6 Unifocal Langerhans-cell histiocytosis
0.487 0.513 0.000
C96.5 Multifocal and unisystemic Langerhans-cell histiocytosis
0.487 0.513 0.000
C96.4 Sarcoma of dendritic cells (accessory cells)
0.487 0.513 0.000
C96.3 True histiocytic lymphoma
0.487 0.513 0.000
C96.2 Malignant mast cell tumour
0.487 0.513 0.000
C96.1 Malignant histiocytosis
0.487 0.513 0.000
C96.0 Letterer-Siwe disease
0.487 0.513 0.000
M06.9 Rheumatoid arthritis, unspecified
0.487 0.513 0.000
M06 Other rheumatoid arthritis
0.482 0.518 0.000
M06.0 Seronegative rheumatoid arthritis
0.481 0.519 0.000
E13.8 With unspecified complications
0.000 0.525 0.475
E13.7 With multiple complications
0.000 0.525 0.475
E13.6 With other specified complications
0.000 0.525 0.475
E13.5 With peripheral circulatory complications
0.000 0.525 0.475
E13.4 With neurological complications
0.000 0.525 0.475
E13.3 With ophthalmic complications
0.000 0.525 0.475
E13.2 With renal complications
0.000 0.525 0.475
E13.1 With ketoacidosis
0.000 0.525 0.475
E13.0 With coma
0.000 0.525 0.475
M06.00 Seronegative rheumatoid arthritis (Multiple sites)
0.474 0.526 0.000
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx
0.471 0.529 0.000
D80 Immunodeficiency with predominantly antibody defects
0.000 0.530 0.470
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.468 0.532 0.000
C91 Lymphoid leukaemia
0.466 0.533 0.001
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.463 0.537 0.000
E29 Testicular dysfunction
0.000 0.539 0.461
D59 Acquired haemolytic anaemia
0.000 0.539 0.461
D52.9 Folate deficiency anaemia, unspecified
0.000 0.539 0.461
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.541 0.459
E14.3 With ophthalmic complications
0.000 0.546 0.454
E24.9 Cushing's syndrome, unspecified
0.000 0.548 0.452
D84 Other immunodeficiencies
0.001 0.548 0.452
C95.7 Other leukaemia of unspecified cell type
0.449 0.551 0.000
C95.2 Subacute leukaemia of unspecified cell type
0.449 0.551 0.000
C95.1 Chronic leukaemia of unspecified cell type
0.449 0.551 0.000
C95.0 Acute leukaemia of unspecified cell type
0.449 0.551 0.000
E14.8 With unspecified complications
0.000 0.554 0.446
E14.7 With multiple complications
0.000 0.554 0.446
E14.2 Withrenal complications
0.000 0.554 0.446
E14.1 With ketoacidosis
0.000 0.554 0.446
E14.0 With coma
0.000 0.554 0.446
K52.0 Gastro-enteritis and colitis due to radiation
0.445 0.555 0.000
C84.9 Mature T/NK-cell lymphoma, unspecified
0.442 0.558 0.000
C84.8 Cutaneous T-cell lymphoma, unspecified
0.442 0.558 0.000
C84.7 Anaplastic large cell lymphoma, ALK-negative
0.442 0.558 0.000
C84.6 Anaplastic large cell lymphoma, ALK-positive
0.442 0.558 0.000
C84.3 Lymphoepithelioid lymphoma
0.442 0.558 0.000
C84.2 T-zone lymphoma
0.442 0.558 0.000
C84.1 Sezary's diease
0.442 0.558 0.000
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.441 0.559 0.000
C02 Malignant neoplasm of other and unspecified parts of tongue
0.440 0.560 0.000
C84.0 Mycosis fungoides
0.440 0.560 0.000
E34.0 Carcinoid syndrome
0.000 0.564 0.436
E12.9 Without complications
0.000 0.564 0.435
E12.8 With unspecified complications
0.000 0.564 0.435
E12.7 With multiple complications
0.000 0.564 0.435
E12.6 With other specified complications
0.000 0.564 0.435
E12.5 With peripheral circulatory complications
0.000 0.564 0.435
E12.4 With neurological complications
0.000 0.564 0.435
E12.3 With ophthalmic complications
0.000 0.564 0.435
E12.2 With renal complications
0.000 0.564 0.435
E12.1 With ketoacidosis
0.000 0.564 0.435
E12.0 With coma
0.000 0.564 0.435
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.567 0.433
E21.4 Other specified disorders of parathyroid gland
0.000 0.567 0.433
E21.2 Other hyperparathyroidism
0.000 0.567 0.433
C88.9 Malignant immunoproliferative disease, unspecified
0.431 0.569 0.000
C88.7 Other malignant immunoproliferative diseases
0.431 0.569 0.000
C88.4 Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue [MALT-lymphoma]
0.431 0.569 0.000
C88.3 Immunoproliferative small intestinal disease
0.431 0.569 0.000
C88.2 Gamma heavy chain disease
0.431 0.569 0.000
C88.1 Alpha heavy chain disease
0.431 0.569 0.000
D52.8 Other folate deficiency anaemias
0.000 0.570 0.429
D52.1 Drug-induced folate deficiency anaemia
0.000 0.570 0.429
D52.0 Dietary folate deficiency anaemia
0.000 0.570 0.429
E14.6 With other specified complications
0.000 0.571 0.429
E14.5 With peripheral circulatory complications
0.000 0.575 0.425
C43 Malignant melanoma of skin
0.423 0.577 0.000
C74 Malignant neoplasm of adrenal gland
0.419 0.581 0.000
M06.09 Seronegative rheumatoid arthritis (Site unspecified)
0.418 0.582 0.000
C84.4 Peripheral T-cell lymphoma
0.416 0.584 0.000
E24.8 Other Cushing's syndrome
0.000 0.585 0.414
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.585 0.414
E24.3 Ectopic ACTH syndrome
0.000 0.585 0.414
E24.2 Drug-induced Cushing's syndrome
0.000 0.585 0.414
E24.1 Nelson's syndrome
0.000 0.585 0.414
E24.0 Pituitary-dependent Cushing's disease
0.000 0.585 0.414
C84.5 Other and unspecified T-cell lymphomas
0.412 0.587 0.000
M06.98 Rheumatoid arthritis, unspecified (Other)
0.408 0.592 0.000
D81.9 Combined immunodeficiency, unspecified
0.000 0.597 0.403
D81.8 Other combined immunodeficiencies
0.000 0.597 0.403
D81.7 Major histocompatibility complex class II deficiency
0.000 0.597 0.403
D81.6 Major histocompatibility complex class I deficiency
0.000 0.597 0.403
D81.5 Purine nucleoside phosphorylase [PNP] deficiency
0.000 0.597 0.403
D81.4 Nezelof's syndrome
0.000 0.597 0.403
D81.3 Adenosine deaminase [ADA] deficiency
0.000 0.597 0.403
D81.2 Severe combined immunodeficiency [SCID] with low or normal B-cell numbers
0.000 0.597 0.403
D81.1 Severe combined immunodeficiency [SCID] with low T- and B-cell numbers
0.000 0.597 0.403
D81.0 Severe combined immunodeficiency [SCID] with reticular dysgenesis
0.000 0.597 0.403
D82.9 Immunodeficiency associated with major defect, unspecified
0.000 0.597 0.403
D82.8 Immunodeficiency associated with other specified major defects
0.000 0.597 0.403
D82.4 Hyperimmunoglobulin E [IgE] syndrome
0.000 0.597 0.403
D82.3 Immunodeficiency following hereditary defective response to Epstein-Barr virus
0.000 0.597 0.403
D82.2 Immunodeficiency with short-limbed stature
0.000 0.597 0.403
D82.1 Di George's syndrome
0.000 0.597 0.403
D82.0 Wiskott-Aldrich syndrome
0.000 0.597 0.403
D59.1 Other autoimmune haemolytic anaemias
0.000 0.597 0.403
D89 Other disorders involving the immune mechanism, not elsewhere classified
0.000 0.598 0.402
C02.1 Border of tongue
0.401 0.598 0.000
C91.5 Adult T-cell leukaemia
0.400 0.599 0.001
E00-E07 Disorders of thyroid gland
0.000 0.601 0.399
C83.0 Small cell (diffuse)
0.398 0.601 0.001
C95.9 Leukaemia, unspecified
0.395 0.605 0.000
E14.4 With neurological complications
0.000 0.606 0.394
C75 Malignant neoplasm of other endocrine glands and related structures
0.393 0.607 0.000
C40-C41 Malignant neoplasms of bone and articular cartilage
0.391 0.608 0.000
E66 Obesity
0.000 0.608 0.391
C06 Malignant neoplasm of other and unspecified parts of mouth
0.391 0.609 0.000
D53.8 Other specified nutritional anaemias
0.000 0.610 0.390
D53.2 Scorbutic anaemia
0.000 0.610 0.390
D53.1 Other megaloblastic anaemias, not elsewhere classified
0.000 0.610 0.390
D53.0 Protein deficiency anaemia
0.000 0.610 0.390
E25.9 Adrenogenital disorder, unspecified
0.000 0.612 0.387
E25.8 Other adrenogenital disorders
0.000 0.612 0.387
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.612 0.387
E30.9 Disorder of puberty, unspecified
0.000 0.612 0.387
E30.8 Other disorders of puberty
0.000 0.612 0.387
E30.1 Precocious puberty
0.000 0.612 0.387
E30.0 Delayed puberty
0.000 0.612 0.387
E31.9 Polyglandular dysfunction, unspecified
0.000 0.612 0.387
E31.8 Other polyglandular dysfunction
0.000 0.612 0.387
E31.1 Polyglandular hyperfunction
0.000 0.612 0.387
E31.0 Autoimmune polyglandular failure
0.000 0.612 0.387
E32.9 Disease of thymus, unspecified
0.000 0.612 0.387
E32.8 Other diseases of thymus
0.000 0.612 0.387
E32.1 Abscess of thymus
0.000 0.612 0.387
E32.0 Persistent hyperplasia of thymus
0.000 0.612 0.387
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.612 0.387
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.612 0.387
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.612 0.387
E20.8 Other hypoparathyroidism
0.000 0.614 0.386
E20.1 Pseudohypoparathyroidism
0.000 0.614 0.386
E20.0 Idiopathic hypoparathyroidism
0.000 0.614 0.386
D57 Sickle-cell disorders
0.000 0.615 0.385
D55 Anaemia due to enzyme disorders
0.000 0.615 0.385
E20.9 Hypoparathyroidism, unspecified
0.000 0.616 0.384
C05 Malignant neoplasm of palate
0.382 0.617 0.000
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.381 0.619 0.000
E34.5 Androgen resistance syndrome
0.000 0.622 0.378
E34.4 Constitutional tall stature
0.000 0.622 0.378
E34.3 Short stature, not elsewhere classified
0.000 0.622 0.378
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.622 0.378
E34.1 Other hypersecretion of intestinal hormones
0.000 0.622 0.378
C97-C97 Malignant neoplasms of independent (primary) multiple sites
0.378 0.622 0.000
C90.3 Solitary plasmacytoma
0.377 0.623 0.000
C90.1 Plasma cell leukaemia
0.377 0.623 0.000
C91.9 Lymphoid leukaemia, unspecified
0.376 0.623 0.001
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.374 0.626 0.000
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.626 0.374
E45 Retarded development following protein-energy malnutrition
0.000 0.626 0.374
E43 Unspecified severe protein-energy malnutrition
0.000 0.626 0.374
E42 Marasmic kwashiorkor
0.000 0.626 0.374
E41 Nutritional marasmus
0.000 0.626 0.374
E40 Kwashiorkor
0.000 0.626 0.374
C43.6 Malignant melanoma of upper limb, including shoulder
0.371 0.629 0.000
D83.8 Other common variable immunodeficiencies
0.000 0.631 0.368
D83.2 Common variable immunodeficiency with autoantibodies to B- or T-cells
0.000 0.631 0.368
D83.1 Common variable immunodeficiency with predominant immunoregulatory T-cell disorders
0.000 0.631 0.368
D83.0 Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
0.000 0.631 0.368
E67 Other hyperalimentation
0.000 0.632 0.367
E68 Sequelae of hyperalimentation
0.000 0.632 0.367
D53.9 Nutritional anaemia, unspecified
0.000 0.634 0.366
C92 Myeloid leukaemia
0.365 0.634 0.000
M06.06 Seronegative rheumatoid arthritis (Lower leg)
0.365 0.635 0.000
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.365 0.635 0.000
C43.4 Malignant melanoma of scalp and neck
0.365 0.635 0.000
J45 Asthma
0.000 0.637 0.363
C03 Malignant neoplasm of gum
0.361 0.639 0.000
E21.3 Hyperparathyroidism, unspecified
0.000 0.639 0.361
C88.0 Waldenstrom's macroglobulinaemia
0.353 0.646 0.000
C10 Malignant neoplasm of oropharynx
0.352 0.647 0.000
E34.8 Other specified endocrine disorders
0.000 0.652 0.348
C02.9 Tongue, unspecified
0.347 0.653 0.000
E03 Other hypothyroidism
0.000 0.653 0.347
M06.8 Other specified rheumatoid arthritis
0.345 0.654 0.000
M06.2 Rheumatoid bursitis
0.345 0.654 0.000
M06.1 Adult-onset Still's disease
0.345 0.654 0.000
E28 Ovarian dysfunction
0.000 0.655 0.345
D50.0 Iron deficiency anaemia secondary to blood loss (chronic)
0.000 0.655 0.345
M06.08 Seronegative rheumatoid arthritis (Other)
0.345 0.655 0.000
M06.07 Seronegative rheumatoid arthritis (Ankle and foot)
0.345 0.655 0.000
M06.05 Seronegative rheumatoid arthritis (Pelvic region and thigh)
0.345 0.655 0.000
M06.04 Seronegative rheumatoid arthritis (Hand)
0.345 0.655 0.000
M06.03 Seronegative rheumatoid arthritis (Forearm)
0.345 0.655 0.000
M06.02 Seronegative rheumatoid arthritis (Upper arm)
0.345 0.655 0.000
M06.01 Seronegative rheumatoid arthritis (Shoulder region)
0.345 0.655 0.000
C02.2 Ventral surface of tongue
0.344 0.655 0.000
C69-C72 Malignant neoplasms of eye, brain and other parts of central nervous system
0.343 0.657 0.000
C00 Malignant neoplasm of lip
0.342 0.658 0.000
M06.3 Rheumatoid nodule
0.340 0.660 0.000
M05-M14 Inflammatory polyarthropathies
0.339 0.661 0.000
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.662 0.338
D59.9 Acquired haemolytic anaemia, unspecified
0.000 0.662 0.338
C13 Malignant neoplasm of hypopharynx
0.338 0.662 0.000
C08 Malignant neoplasm of other and unspecified major salivary glands
0.338 0.662 0.000
D80.9 Immunodeficiency with predominantly antibody defects, unspecified
0.000 0.663 0.337
D80.8 Other immunodeficiencies with predominantly antibody defects
0.000 0.663 0.337
D80.7 Transient hypogammaglobulinaemia of infancy
0.000 0.663 0.337
D80.6 Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinaemia
0.000 0.663 0.337
D80.5 Immunodeficiency with increased immunoglobulin M [IgM]
0.000 0.663 0.337
D80.4 Selective deficiency of immunoglobulin M [IgM]
0.000 0.663 0.337
D80.3 Selective deficiency of immunoglobulin G [IgG] subclasses
0.000 0.663 0.337
D80.0 Hereditary hypogammaglobulinaemia
0.000 0.663 0.337
E50-E64 Other nutritional deficiencies
0.000 0.664 0.336
C91.8 Mature B-cell leukaemia Burkitt-type
0.334 0.665 0.001
C91.7 Other lymphoid leukaemia
0.334 0.665 0.001
C91.6 Prolymphocytic leukaemia of T-cell type
0.334 0.665 0.001
C91.3 Prolymphocytic leukaemia
0.334 0.665 0.001
C91.2 Subacute lymphocytic leukaemia
0.334 0.665 0.001
C81.9 Hodgkin's disease, unspecified
0.332 0.667 0.000
E29.9 Testicular dysfunction, unspecified
0.000 0.669 0.331
E29.8 Other testicular dysfunction
0.000 0.669 0.331
E29.0 Testicular hyperfunction
0.000 0.669 0.331
M06.4 Inflammatory polyarthropathy
0.331 0.669 0.000
C12 Malignant neoplasm of pyriform sinus
0.330 0.669 0.000
D59.8 Other acquired haemolytic anaemias
0.000 0.669 0.330
D59.6 Haemoglobinuria due to haemolysis from other external causes
0.000 0.669 0.330
D59.5 Paroxysmal nocturnal haemoglobinuria [Marchiafava-Micheli]
0.000 0.669 0.330
D59.4 Other nonautoimmune haemolytic anaemias
0.000 0.669 0.330
D59.3 Haemolytic-uraemic syndrome
0.000 0.669 0.330
D59.2 Drug-induced nonautoimmune haemolytic anaemia
0.000 0.669 0.330
D59.0 Drug-induced autoimmune haemolytic anaemia
0.000 0.669 0.330
E46 Unspecified protein-energy malnutrition
0.000 0.670 0.330
C14 Malignant neoplasm of other and ill-defined sites in the lip, oral cavity and pharynx
0.329 0.671 0.000
C74.9 Adrenal gland, unspecified
0.326 0.674 0.000
D56 Thalassaemia
0.000 0.674 0.326
E27.9 Disorder of adrenal gland, unspecified
0.001 0.674 0.325
C90.0 Multiple myeloma
0.325 0.675 0.000
D84.8 Other specified immunodeficiencies
0.001 0.676 0.324
D84.1 Defects in the complement system
0.001 0.676 0.324
D84.0 Lymphocyte function antigen-1 [LFA-1] defect
0.001 0.676 0.324
C11 Malignant neoplasm of nasopharynx
0.324 0.676 0.000
C06.0 Cheek mucosa
0.323 0.677 0.000
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.679 0.321
D83.9 Common variable immunodeficiency, unspecified
0.000 0.680 0.320
E26 Hyperaldosteronism
0.002 0.684 0.314
C02.8 Overlapping lesion of tongue
0.316 0.684 0.000
C02.4 Lingual tonsil
0.316 0.684 0.000
C02.3 Anterior two-thirds of tongue, part unspecified
0.316 0.684 0.000
C02.0 Dorsal surface of tongue
0.316 0.684 0.000
E03.9 Hypothyroidism, unspecified
0.000 0.685 0.315
M07 Psoriatic and enteropathic arthropathies
0.311 0.689 0.000
D58 Other hereditary haemolytic anaemias
0.000 0.692 0.307
E34.9 Endocrine disorder, unspecified
0.000 0.693 0.307
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.306 0.694 0.000
E66.8 Other obesity
0.000 0.694 0.306
M05 Seropositive rheumatoid arthritis
0.305 0.695 0.000
D80.1 Nonfamilial hypogammaglobulinaemia
0.000 0.695 0.305
C05.1 Soft palate
0.304 0.696 0.000
C43.8 Overlapping malignant melanoma of skin
0.303 0.697 0.000
C43.1 Malignant melanoma of eyelid, including canthus
0.303 0.697 0.000
C43.0 Malignant melanoma of lip
0.303 0.697 0.000
E66.9 Obesity, unspecified
0.000 0.697 0.303
C90.2 Plasmacytoma, extramedullary
0.302 0.698 0.000
C74.1 Medulla of adrenal gland
0.300 0.700 0.000
C74.0 Cortex of adrenal gland
0.300 0.700 0.000
C43.2 Malignant melanoma of ear and external auricular canal
0.296 0.703 0.000
C05.0 Hard palate
0.295 0.705 0.000
C06.2 Retromolar area
0.294 0.706 0.000
M07.3 Other psoriatic arthropathies
0.292 0.708 0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.000 0.709 0.291
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.290 0.710 0.000
C04 Malignant neoplasm of floor of mouth
0.289 0.710 0.000
E66.2 Extreme obesity with alveolar hypoventilation
0.000 0.711 0.289
D80.2 Selective deficiency of immunoglobulin A [IgA]
0.000 0.711 0.288
D89.9 Disorder involving the immune mechanism, unspecified
0.000 0.712 0.288
D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified
0.000 0.712 0.288
D89.3 Immune reconstitution syndrome
0.000 0.712 0.288
D89.0 Polyclonal hypergammaglobulinaemia
0.000 0.712 0.288
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.714 0.286
E00 Congenital iodine-deficiency syndrome
0.000 0.714 0.286
C06.9 Mouth, unspecified
0.285 0.714 0.000
C01 Malignant neoplasm of base of tongue
0.284 0.716 0.000
C03.1 Lower gum
0.282 0.717 0.000
C75.9 Endocrine gland, unspecified
0.282 0.718 0.000
C75.8 Pluriglandular involvement, unspecified
0.282 0.718 0.000
C75.5 Aortic body and other paraganglia
0.282 0.718 0.000
C75.4 Carotid body
0.282 0.718 0.000
C75.3 Pineal gland
0.282 0.718 0.000
C75.2 Craniopharyngeal duct
0.282 0.718 0.000
C75.1 Pituitary gland
0.282 0.718 0.000
C75.0 Parathyroid gland
0.282 0.718 0.000
M05.9 Seropositive rheumatoid arthritis, unspecified
0.281 0.719 0.000
C42 hematopoietic and reticuloendothelial systems (ICD-O-3 specific)
0.281 0.719 0.000
C40 Malignant neoplasm of bone and articular cartilage of limbs
0.281 0.719 0.000
E66.1 Drug-induced obesity
0.000 0.719 0.281
C06.8 Overlapping lesion of other and unspecified parts of mouth
0.280 0.719 0.000
C06.1 Vestibule of mouth
0.280 0.719 0.000
C41 Malignant neoplasm of bone and articular cartilage of other and unspecified sites
0.278 0.722 0.000
D55.9 Anaemia due to enzyme disorder, unspecified
0.000 0.724 0.276
D55.8 Other anaemias due to enzyme disorders
0.000 0.724 0.276
D55.3 Anaemia due to disorders of nucleotide metabolism
0.000 0.724 0.276
D55.2 Anaemia due to disorders of glycolytic enzymes
0.000 0.724 0.276
D55.1 Anaemia due to other disorders of glutathione metabolism
0.000 0.724 0.276
D55.0 Anaemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiency
0.000 0.724 0.276
D57.8 Other sickle-cell disorders
0.000 0.724 0.276
D57.3 Sickle-cell trait
0.000 0.724 0.276
D57.2 Double heterozygous sickling disorders
0.000 0.724 0.276
D57.1 Sickle-cell anaemia without crisis
0.000 0.724 0.276

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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