TreeWAS – Variant ID: rs12533251

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
O46.9 Antepartum haemorrhage, unspecified	0.189	0.811	0.000
O46 Antepartum haemorrhage, not elsewhere classified	0.181	0.819	0.000
O36 Maternal care for other known or suspected foetal problems	0.178	0.822	0.000
O36.8 Maternal care for other specified foetal problems	0.177	0.823	0.000
O30-O48 Maternal care related to the fetus and amniotic cavity and possible delivery problems	0.175	0.825	0.000
O30 Multiple gestation	0.158	0.842	0.000
O36.9 Maternal care for foetal problem, unspecified	0.152	0.848	0.000
J44.0 Chronic obstructive pulmonary disease with acute lower respiratory infection	0.000	0.850	0.150
O48 Prolonged pregnancy	0.146	0.854	0.000
O30.0 Twin pregnancy	0.146	0.854	0.000
O34 Maternal care for known or suspected abnormality of pelvic organs	0.144	0.856	0.000
O44 Placenta praevia	0.141	0.859	0.000
J44 Other chronic obstructive pulmonary disease	0.000	0.866	0.134
O36.6 Maternal care for excessive foetal growth	0.133	0.867	0.000
J44.1 Chronic obstructive pulmonary disease with acute exacerbation, unspecified	0.000	0.868	0.132
O36.3 Maternal care for signs of foetal hypoxia	0.130	0.870	0.000
O46.8 Other antepartum haemorrhage	0.130	0.870	0.000
O46.0 Antepartum haemorrhage with coagulation defect	0.130	0.870	0.000
O36.5 Maternal care for poor foetal growth	0.130	0.870	0.000
O45 Premature separation of placenta [abruptio placentae]	0.128	0.872	0.000
O36.7 Maternal care for viable foetus in abdominal pregnancy	0.127	0.872	0.000
O36.2 Maternal care for hydrops foetalis	0.127	0.872	0.000
O36.1 Maternal care for other isoimmunisation	0.127	0.872	0.000
O33 Maternal care for known or suspected disproportion	0.127	0.872	0.000
O35 Maternal care for known or suspected foetal abnormality and damage	0.127	0.873	0.000
O36.0 Maternal care for rhesus isoimmunisation	0.127	0.873	0.000
O31 Complications specific to multiple gestation	0.126	0.874	0.000
O42 Premature rupture of membranes	0.125	0.875	0.000
O36.4 Maternal care for intra-uterine death	0.122	0.878	0.000
O34.2 Maternal care due to uterine scar from previous surgery	0.116	0.884	0.000
O34.1 Maternal care for tumour of corpus uteri	0.115	0.885	0.000
O30.9 Multiple gestation, unspecified	0.113	0.886	0.000
O30.8 Other multiple gestation	0.113	0.886	0.000
O30.2 Quadruplet pregnancy	0.113	0.886	0.000
O30.1 Triplet pregnancy	0.113	0.886	0.000
O44.0 Placenta praevia specified as without haemorrhage	0.113	0.887	0.000
O34.8 Maternal care for other abnormalities of pelvic organs	0.113	0.887	0.000
O41 Other disorders of amniotic fluid and membranes	0.109	0.891	0.000
O40 Polyhydramnios	0.107	0.893	0.000
O44.1 Placenta praevia with haemorrhage	0.105	0.895	0.000
O32 Maternal care for known or suspected malpresentation of foetus	0.104	0.895	0.000
O34.9 Maternal care for abnormality of pelvic organ, unspecified	0.103	0.897	0.000
O34.6 Maternal care for abnormality of vagina	0.103	0.897	0.000
O34.5 Maternal care for other abnormalities of gravid uterus	0.103	0.897	0.000
O34.3 Maternal care for cervical incompetence	0.103	0.897	0.000
O34.0 Maternal care for congenital malformation of uterus	0.103	0.897	0.000
O35.9 Maternal care for (suspected) foetal abnormality and damage, unspecified	0.099	0.901	0.000
O34.4 Maternal care for other abnormalities of cervix	0.098	0.902	0.000
O42.1 Premature rupture of membranes, onset of labour after 24 hours	0.097	0.903	0.000
O45.9 Premature separation of placenta, unspecified	0.094	0.906	0.000
J44.9 Chronic obstructive pulmonary disease, unspecified	0.000	0.907	0.093
O33.9 Maternal care for disproportion, unspecified	0.093	0.907	0.000
O45.8 Other premature separation of placenta	0.092	0.908	0.000
O45.0 Premature separation of placenta with coagulation defect	0.092	0.908	0.000
O33.8 Maternal care for disproportion of other origin	0.091	0.908	0.000
O33.7 Maternal care for disproportion due to other foetal deformities	0.091	0.908	0.000
O33.6 Maternal care for disproportion due to hydrocephalic foetus	0.091	0.908	0.000
O33.5 Maternal care for disproportion due to unusually large foetus	0.091	0.908	0.000
O33.4 Maternal care for disproportion of mixed maternal and foetal origin	0.091	0.908	0.000
O33.3 Maternal care for disproportion due to outlet contraction of pelvis	0.091	0.908	0.000
O33.2 Maternal care for disproportion due to inlet contraction of pelvis	0.091	0.908	0.000
O33.1 Maternal care for disproportion due to generally contracted pelvis	0.091	0.908	0.000
O33.0 Maternal care for disproportion due to deformity of maternal pelvic bones	0.091	0.908	0.000
O43 Placental disorders	0.091	0.908	0.000
J44.8 Other specified chronic obstructive pulmonary disease	0.000	0.908	0.092
O35.7 Maternal care for (suspected) damage to foetus by other medical procedures	0.091	0.909	0.000
O35.6 Maternal care for (suspected) damage to foetus by radiation	0.091	0.909	0.000
O35.5 Maternal care for (suspected) damage to foetus by drugs	0.091	0.909	0.000
O35.4 Maternal care for (suspected) damage to foetus from alcohol	0.091	0.909	0.000
O35.3 Maternal care for (suspected) damage to foetus from viral disease in mother	0.091	0.909	0.000
O35.2 Maternal care for (suspected) hereditary disease in foetus	0.091	0.909	0.000
O35.0 Maternal care for (suspected) central nervous system malformation in foetus	0.091	0.909	0.000
O31.8 Other complications specific to multiple gestation	0.090	0.909	0.000
O31.2 Continuing pregnancy after intra-uterine death of one foetus or more	0.090	0.909	0.000
O31.1 Continuing pregnancy after abortion of one foetus or more	0.090	0.909	0.000
O31.0 Papyraceous foetus	0.090	0.909	0.000
O34.7 Maternal care for abnormality of vulva and perineum	0.090	0.910	0.000
O42.2 Premature rupture of membranes, labour delayed by therapy	0.090	0.910	0.000
O42.9 Premature rupture of membranes, unspecified	0.090	0.910	0.000
O35.8 Maternal care for other (suspected) foetal abnormality and damage	0.087	0.913	0.000
O35.1 Maternal care for (suspected) chromosomal abnormality in foetus	0.087	0.913	0.000
O32.4 Maternal care for high head at term	0.084	0.916	0.000
O32.0 Maternal care for unstable lie	0.082	0.917	0.000
O42.0 Premature rupture of membranes, onset of labour within 24 hours	0.081	0.919	0.000
O32.5 Maternal care for multiple gestation with malpresentation of one foetus or more	0.080	0.919	0.000
O32.8 Maternal care for other malpresentation of foetus	0.080	0.920	0.000
O41.0 Oligohydramnios	0.079	0.921	0.000
O41.9 Disorder of amniotic fluid and membranes, unspecified	0.078	0.921	0.000
O41.1 Infection of amniotic sac and membranes	0.078	0.921	0.000
O32.9 Maternal care for malpresentation of foetus, unspecified	0.075	0.925	0.000
O32.6 Maternal care for compound presentation	0.075	0.925	0.000
O32.3 Maternal care for face, brow and chin presentation	0.075	0.925	0.000
O43.9 Placental disorder, unspecified	0.066	0.934	0.000
O43.2 Morbidly adherent placenta	0.066	0.934	0.000
O43.0 Placental transfusion syndromes	0.066	0.934	0.000
O41.8 Other specified disorders of amniotic fluid and membranes	0.062	0.938	0.000
O47 False labour	0.059	0.941	0.000
O43.8 Other placental disorders	0.058	0.942	0.000
O32.2 Maternal care for transverse and oblique lie	0.056	0.943	0.000
D69.6 Thrombocytopenia, unspecified	0.054	0.946	0.000
D69 Purpura and other haemorrhagic conditions	0.052	0.948	0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions	0.049	0.951	0.000
D68 Other coagulation defects	0.049	0.951	0.000
O43.1 Malformation of placenta	0.045	0.955	0.001
D68.8 Other specified coagulation defects	0.044	0.956	0.000
D69.3 Idiopathic thrombocytopenic purpura	0.044	0.956	0.000
D68.5 Primary Thrombophilia	0.043	0.957	0.000
D69.5 Secondary thrombocytopenia	0.042	0.958	0.000
D68.2 Hereditary deficiency of other clotting factors	0.041	0.959	0.000
O47.9 False labour, unspecified	0.040	0.960	0.000
D68.6 Other Thrombophilia	0.040	0.960	0.000
D69.4 Other primary thrombocytopenia	0.039	0.961	0.000
D69.8 Other specified haemorrhagic conditions	0.038	0.962	0.000
D69.2 Other nonthrombocytopenic purpura	0.038	0.962	0.000
D69.1 Qualitative platelet defects	0.038	0.962	0.000
D69.9 Haemorrhagic condition, unspecified	0.037	0.963	0.000
Chapter XV Pregnancy, childbirth and the puerperium	0.036	0.964	0.000
D68.3 Haemorrhagic disorder due to circulating anticoagulants	0.035	0.964	0.000
D68.0 Von Willebrand's disease	0.035	0.965	0.000
D67 Hereditary factor IX deficiency	0.035	0.965	0.000
D65 Disseminated intravascular coagulation [defibrination syndrome]	0.035	0.965	0.000
D68.4 Acquired coagulation factor deficiency	0.035	0.965	0.000
D68.1 Hereditary factor XI deficiency	0.035	0.965	0.000
D69.0 Allergic purpura	0.034	0.966	0.000
O85-O92 Complications predominantly related to the puerperium	0.033	0.966	0.000
D63.0 Anaemia in neoplastic disease	0.033	0.967	0.000
D63 Anaemia in chronic diseases classified elsewhere	0.032	0.968	0.000
I21.4 Acute subendocardial myocardial infarction	0.000	0.968	0.032
O80-O84 Delivery	0.032	0.968	0.000
O86 Other puerperal infections	0.031	0.969	0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	0.031	0.969	0.000
D66 Hereditary factor VIII deficiency	0.029	0.971	0.000
D60-D64 Aplastic and other anaemias	0.029	0.971	0.000
D63.8 Anaemia in other chronic diseases classified elsewhere	0.029	0.971	0.000
O86.0 Infection of obstetric surgical wound	0.028	0.972	0.000
O82 Single delivery by Caesarean section	0.028	0.972	0.000
D68.9 Coagulation defect, unspecified	0.027	0.973	0.000
D55-D59 Haemolytic anaemias	0.027	0.973	0.000
O90 Complications of the puerperium, not elsewhere classified	0.026	0.974	0.000
J40-J47 Chronic lower respiratory diseases	0.000	0.974	0.026
O92 Other disorders of breast and lactation associated with childbirth	0.025	0.975	0.000
O86.1 Other infection of genital tract following delivery	0.025	0.975	0.000
O86.4 Pyrexia of unknown origin following delivery	0.025	0.975	0.000
O47.0 False labour before 37 completed weeks of gestation	0.024	0.975	0.001
O91 Infections of breast associated with childbirth	0.024	0.976	0.000
O89 Complications of anaesthesia during the puerperium	0.024	0.976	0.000
O88 Obstetric embolism	0.024	0.976	0.000
O82.0 Delivery by elective Caesarean section	0.024	0.976	0.000
O60-O75 Complications of labour and delivery	0.024	0.976	0.000
O47.1 False labour at or after 37 completed weeks of gestation	0.024	0.976	0.000
O80 Single spontaneous delivery	0.024	0.976	0.000
O81 Single delivery by forceps and vacuum extractor	0.024	0.976	0.000
O85 Puerperal sepsis	0.024	0.976	0.000
D63.1 Anaemia in other chronic diseases classified elsewhere	0.023	0.977	0.000
O84 Multiple delivery	0.023	0.977	0.000
O83 Other assisted single delivery	0.023	0.977	0.000
O87 Venous complications in the puerperium	0.023	0.977	0.000
O86.8 Other specified puerperal infections	0.023	0.977	0.000
O86.3 Other genito-urinary tract infections following delivery	0.023	0.977	0.000
O86.2 Urinary tract infection following delivery	0.023	0.977	0.000
D58 Other hereditary haemolytic anaemias	0.023	0.977	0.000
O94-O99 Other obstetric conditions, not elsewhere classified	0.023	0.977	0.000
D70-D77 Other diseases of blood and blood-forming organs	0.022	0.978	0.000
J42 Unspecified chronic bronchitis	0.000	0.978	0.022
D56 Thalassaemia	0.021	0.978	0.000
O82.1 Delivery by emergency Caesarean section	0.021	0.979	0.000
D60 Acquired pure red cell aplasia [erythroblastopenia]	0.021	0.979	0.000
D59 Acquired haemolytic anaemia	0.021	0.979	0.000
J43 Emphysema	0.000	0.979	0.021
D61 Other aplastic anaemias	0.021	0.979	0.000
D75 Other diseases of blood and blood-forming organs	0.021	0.979	0.000
O90.8 Other complications of the puerperium, not elsewhere classified	0.020	0.980	0.000
O82.9 Delivery by Caesarean section, unspecified	0.020	0.980	0.000
O66 Other obstructed labour	0.020	0.980	0.000
O80.8 Other single spontaneous delivery	0.020	0.980	0.000
O82.8 Other single delivery by Caesarean section	0.020	0.980	0.000
O82.2 Delivery by Caesarean hysterectomy	0.020	0.980	0.000
D75.2 Essential thrombocytosis	0.020	0.980	0.000
O70 Perineal laceration during delivery	0.020	0.980	0.000
J46 Status asthmaticus	0.000	0.980	0.020
O73 Retained placenta and membranes, without haemorrhage	0.020	0.980	0.000
D57 Sickle-cell disorders	0.019	0.980	0.000
D55 Anaemia due to enzyme disorders	0.019	0.980	0.000
O92.1 Cracked nipple associated with childbirth	0.019	0.981	0.000
D72 Other disorders of white blood cells	0.019	0.981	0.000
O63 Long labour	0.019	0.981	0.000
D75.9 Disease of blood and blood-forming organs, unspecified	0.019	0.981	0.000
O64 Obstructed labour due to malposition and malpresentation of foetus	0.019	0.981	0.000
O90.9 Complication of the puerperium, unspecified	0.019	0.981	0.000
O90.5 Postpartum thyroiditis	0.019	0.981	0.000
O90.4 Postpartum acute renal failure	0.019	0.981	0.000
O90.3 Cardiomyopathy in the puerperium	0.019	0.981	0.000
O90.2 Haematoma of obstetric wound	0.019	0.981	0.000
O90.1 Disruption of perineal obstetric wound	0.019	0.981	0.000
O90.0 Disruption of Caesarean section wound	0.019	0.981	0.000
O80.9 Single spontaneous delivery, unspecified	0.019	0.981	0.000
J43.9 Emphysema, unspecified	0.000	0.981	0.019
J41 Simple and mucopurulent chronic bronchitis	0.000	0.981	0.019
D58.9 Hereditary haemolytic anaemia, unspecified	0.018	0.981	0.000
D72.8 Other specified disorders of white blood cells	0.018	0.982	0.000
O92.7 Other and unspecified disorders of lactation	0.018	0.982	0.000
O92.6 Galactorrhoea	0.018	0.982	0.000
O92.5 Suppressed lactation	0.018	0.982	0.000
O92.4 Hypogalactia	0.018	0.982	0.000
O92.3 Agalactia	0.018	0.982	0.000
O92.2 Other and unspecified disorders of breast associated with childbirth	0.018	0.982	0.000
O92.0 Retracted nipple associated with childbirth	0.018	0.982	0.000
O81.4 Vacuum extractor delivery	0.018	0.982	0.000
D58.0 Hereditary spherocytosis	0.018	0.982	0.000
O66.5 Failed application of vacuum extractor and forceps, unspecified	0.018	0.982	0.000
O32.1 Maternal care for breech presentation	0.017	0.982	0.001
D80-D89 Certain disorders involving the immune mechanism	0.018	0.982	0.000
D56.3 Thalassaemia trait	0.018	0.982	0.000
O88.8 Other obstetric embolism	0.017	0.982	0.000
O88.3 Obstetric pyaemic and septic embolism	0.017	0.982	0.000
O88.2 Obstetric blood-clot embolism	0.017	0.982	0.000
O88.1 Amniotic fluid embolism	0.017	0.982	0.000
O88.0 Obstetric air embolism	0.017	0.982	0.000
O89.9 Complication of anaesthesia during the puerperium, unspecified	0.017	0.982	0.000
O89.8 Other complications of anaesthesia during the puerperium	0.017	0.982	0.000
O89.6 Failed or difficult intubation during the puerperium	0.017	0.982	0.000
O89.5 Other complications of spinal and epidural anaesthesia during the puerperium	0.017	0.982	0.000
O89.4 Spinal and epidural anaesthesia-induced headache during the puerperium	0.017	0.982	0.000
O89.3 Toxic reaction to local anaesthesia during the puerperium	0.017	0.982	0.000
O89.2 Central nervous system complications of anaesthesia during the puerperium	0.017	0.982	0.000
O89.1 Cardiac complications of anaesthesia during the puerperium	0.017	0.982	0.000
O89.0 Pulmonary complications of anaesthesia during the puerperium	0.017	0.982	0.000
O91.2 Nonpurulent mastitis associated with childbirth	0.017	0.982	0.000
O91.1 Abscess of breast associated with childbirth	0.017	0.982	0.000
O91.0 Infection of nipple associated with childbirth	0.017	0.982	0.000
O74 Complications of anaesthesia during labour and delivery	0.017	0.983	0.000
O65 Obstructed labour due to maternal pelvic abnormality	0.017	0.983	0.000
O60 Preterm delivery	0.017	0.983	0.000
O80.1 Spontaneous breech delivery	0.017	0.983	0.000
O61 Failed induction of labour	0.017	0.983	0.000
O81.5 Delivery by combination of forceps and vacuum extractor	0.017	0.983	0.000
O81.3 Other and unspecified forceps delivery	0.017	0.983	0.000
O81.2 Mid-cavity forceps with rotation	0.017	0.983	0.000
O81.1 Mid-cavity forceps delivery	0.017	0.983	0.000
O81.0 Low forceps delivery	0.017	0.983	0.000
O70.1 Second degree perineal laceration during delivery	0.017	0.983	0.000
O63.1 Prolonged second stage (of labour)	0.017	0.983	0.000
O73.0 Retained placenta, without haemorrhage	0.017	0.983	0.000
O75 Other complications of labour and delivery, not elsewhere classified	0.017	0.983	0.000
R13 Dysphagia	0.000	0.983	0.017
O83.9 Assisted single delivery, unspecified	0.017	0.983	0.000
O83.8 Other specified assisted single delivery	0.017	0.983	0.000
O83.4 Destructive operation for delivery	0.017	0.983	0.000
O83.3 Delivery of viable foetus in abdominal pregnancy	0.017	0.983	0.000
O83.2 Other manipulation-assisted delivery	0.017	0.983	0.000
O83.1 Other assisted breech delivery	0.017	0.983	0.000
O83.0 Breech extraction	0.017	0.983	0.000
O84.9 Multiple delivery, unspecified	0.017	0.983	0.000
O84.8 Other multiple delivery	0.017	0.983	0.000
O84.2 Multiple delivery, all by Caesarean section	0.017	0.983	0.000
O84.1 Multiple delivery, all by forceps and vacuum extractor	0.017	0.983	0.000
O84.0 Multiple delivery, all spontaneous	0.017	0.983	0.000
O87.9 Venous complication in the puerperium, unspecified	0.016	0.983	0.000
O87.8 Other venous complications in the puerperium	0.016	0.983	0.000
O87.3 Cerebral venous thrombosis in the puerperium	0.016	0.983	0.000
O87.1 Deep phlebothrombosis in the puerperium	0.016	0.983	0.000
O87.0 Superficial thrombophlebitis in the puerperium	0.016	0.983	0.000
O70.9 Perineal laceration during delivery, unspecified	0.017	0.983	0.000
D58.8 Other specified hereditary haemolytic anaemias	0.016	0.983	0.000
D58.2 Other haemoglobinopathies	0.016	0.983	0.000
D58.1 Hereditary elliptocytosis	0.016	0.983	0.000
O98 Maternal infectious and parasitic diseases classifiable elsewhere but complicating pregnancy, childbirth and the puerperium	0.016	0.983	0.000
O97 Death from sequelae of direct obstetric causes	0.016	0.983	0.000
O96 Death from any obstetric cause occurring more than 42 days but less than one year after delivery	0.016	0.983	0.000
O95 Obstetric death of unspecified cause	0.016	0.983	0.000
O94 Sequelae of complication of pregnancy, childbirth and the puerperium	0.016	0.983	0.000
O70.2 Third degree perineal laceration during delivery	0.016	0.984	0.000
D74 Methaemoglobinaemia	0.016	0.984	0.000
D77 Other disorders of blood and blood-forming organs in diseases classified elsewhere	0.016	0.984	0.000
D71 Functional disorders of polymorphonuclear neutrophils	0.016	0.984	0.000
O20-O29 Other maternal disorders predominantly related to pregnancy	0.016	0.984	0.000
D61.1 Drug-induced aplastic anaemia	0.016	0.984	0.000
D59.1 Other autoimmune haemolytic anaemias	0.016	0.984	0.000
D25.0 Submucous leiomyoma of uterus	0.000	0.984	0.016
D56.9 Thalassaemia, unspecified	0.016	0.984	0.000
D56.8 Other thalassaemias	0.016	0.984	0.000
D56.4 Hereditary persistence of foetal haemoglobin [HPFH]	0.016	0.984	0.000
D56.2 Delta-beta thalassaemia	0.016	0.984	0.000
D56.1 Beta thalassaemia	0.016	0.984	0.000
D56.0 Alpha thalassaemia	0.016	0.984	0.000
D59.9 Acquired haemolytic anaemia, unspecified	0.015	0.984	0.000
O67 Labour and delivery complicated by intrapartum haemorrhage, not elsewhere classified	0.015	0.984	0.000
O64.1 Obstructed labour due to breech presentation	0.015	0.984	0.000
O71 Other obstetric trauma	0.015	0.984	0.000
O87.2 Haemorrhoids in the puerperium	0.015	0.985	0.000
D60.9 Acquired pure red cell aplasia, unspecified	0.015	0.985	0.000
D60.8 Other acquired pure red cell aplasias	0.015	0.985	0.000
D60.1 Transient acquired pure red cell aplasia	0.015	0.985	0.000
D60.0 Chronic acquired pure red cell aplasia	0.015	0.985	0.000
O72 Postpartum haemorrhage	0.015	0.985	0.000
D59.8 Other acquired haemolytic anaemias	0.015	0.985	0.000
D59.6 Haemoglobinuria due to haemolysis from other external causes	0.015	0.985	0.000
D59.5 Paroxysmal nocturnal haemoglobinuria [Marchiafava-Micheli]	0.015	0.985	0.000
D59.4 Other nonautoimmune haemolytic anaemias	0.015	0.985	0.000
D59.3 Haemolytic-uraemic syndrome	0.015	0.985	0.000
D59.2 Drug-induced nonautoimmune haemolytic anaemia	0.015	0.985	0.000
D59.0 Drug-induced autoimmune haemolytic anaemia	0.015	0.985	0.000
J43.8 Other emphysema	0.000	0.985	0.015
J43.1 Panlobular emphysema	0.000	0.985	0.015
J43.0 MacLeod's syndrome	0.000	0.985	0.015
D61.8 Other specified aplastic anaemias	0.015	0.985	0.000
D61.3 Idiopathic aplastic anaemia	0.015	0.985	0.000
D61.2 Aplastic anaemia due to other external agents	0.015	0.985	0.000
D61.0 Constitutional aplastic anaemia	0.015	0.985	0.000
D75.0 Familial erythrocytosis	0.015	0.985	0.000
O63.9 Long labour, unspecified	0.015	0.985	0.000
O66.9 Obstructed labour, unspecified	0.015	0.985	0.000
O66.8 Other specified obstructed labour	0.015	0.985	0.000
O66.4 Failed trial of labour, unspecified	0.015	0.985	0.000
O66.3 Obstructed labour due to other abnormalities of foetus	0.015	0.985	0.000
O66.2 Obstructed labour due to unusually large foetus	0.015	0.985	0.000
O66.1 Obstructed labour due to locked twins	0.015	0.985	0.000
O70.3 Fourth degree perineal laceration during delivery	0.014	0.985	0.000
O68 Labour and delivery complicated by foetal stress [distress]	0.015	0.985	0.000
D89 Other disorders involving the immune mechanism, not elsewhere classified	0.014	0.986	0.000
D55.9 Anaemia due to enzyme disorder, unspecified	0.014	0.986	0.000
D55.8 Other anaemias due to enzyme disorders	0.014	0.986	0.000
D55.3 Anaemia due to disorders of nucleotide metabolism	0.014	0.986	0.000
D55.2 Anaemia due to disorders of glycolytic enzymes	0.014	0.986	0.000
D55.1 Anaemia due to other disorders of glutathione metabolism	0.014	0.986	0.000
D55.0 Anaemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiency	0.014	0.986	0.000
D57.8 Other sickle-cell disorders	0.014	0.986	0.000
D57.3 Sickle-cell trait	0.014	0.986	0.000
D57.2 Double heterozygous sickling disorders	0.014	0.986	0.000
D57.1 Sickle-cell anaemia without crisis	0.014	0.986	0.000
D57.0 Sickle-cell anaemia with crisis	0.014	0.986	0.000
D72.9 Disorder of white blood cells, unspecified	0.014	0.986	0.000
D72.0 Genetic anomalies of leukocytes	0.014	0.986	0.000
O63.2 Delayed delivery of second twin, triplet, etc.	0.014	0.986	0.000
O75.7 Vaginal delivery following previous Caesarean section	0.014	0.986	0.000
O64.0 Obstructed labour due to incomplete rotation of foetal head	0.014	0.986	0.000
D76 Certain diseases involving lymphoreticular tissue and reticulohistiocytic system	0.014	0.986	0.000
O64.9 Obstructed labour due to malposition and malpresentation, unspecified	0.014	0.986	0.000
O64.8 Obstructed labour due to other malposition and malpresentation	0.014	0.986	0.000
O64.5 Obstructed labour due to compound presentation	0.014	0.986	0.000
O64.4 Obstructed labour due to shoulder presentation	0.014	0.986	0.000
O64.3 Obstructed labour due to brow presentation	0.014	0.986	0.000
O64.2 Obstructed labour due to face presentation	0.014	0.986	0.000
J40 Bronchitis, not specified as acute or chronic	0.000	0.986	0.014
O66.0 Obstructed labour due to shoulder dystocia	0.014	0.986	0.000
J41.8 Mixed simple and mucopurulent chronic bronchitis	0.000	0.986	0.013
J41.1 Mucopurulent chronic bronchitis	0.000	0.986	0.013
J41.0 Simple chronic bronchitis	0.000	0.986	0.013
D61.9 Aplastic anaemia, unspecified	0.014	0.986	0.000
O73.1 Retained portions of placenta and membranes, without haemorrhage	0.013	0.986	0.000
O10-O16 Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium	0.013	0.987	0.000
O68.2 Labour and delivery complicated by foetal heart rate anomaly with meconium in amniotic fluid	0.013	0.987	0.000
D83 Common variable immunodeficiency	0.013	0.987	0.000
D82 Immunodeficiency associated with other major defects	0.013	0.987	0.000
D81 Combined immunodeficiencies	0.013	0.987	0.000
D64 Other anaemias	0.013	0.987	0.000
O69 Labour and delivery complicated by umbilical cord complications	0.013	0.987	0.000
D89.9 Disorder involving the immune mechanism, unspecified	0.013	0.987	0.000
O23 Infections of genito-urinary tract in pregnancy	0.013	0.987	0.000
D73 Diseases of spleen	0.013	0.987	0.000
O60.3 Preterm delivery without spontaneous labour	0.013	0.987	0.000
O60.2 Preterm spontaneous labour with term delivery	0.013	0.987	0.000
O60.1 Preterm spontaneous labour with preterm delivery	0.013	0.987	0.000
O60.0 Preterm labour without delivery	0.013	0.987	0.000
O65.9 Obstructed labour due to maternal pelvic abnormality, unspecified	0.013	0.987	0.000
O65.8 Obstructed labour due to other maternal pelvic abnormalities	0.013	0.987	0.000
O65.5 Obstructed labour due to abnormality of maternal pelvic organs	0.013	0.987	0.000
O65.4 Obstructed labour due to foetopelvic disproportion, unspecified	0.013	0.987	0.000
O65.3 Obstructed labour due to pelvic outlet and midcavity contraction	0.013	0.987	0.000
O65.2 Obstructed labour due to pelvic inlet contraction	0.013	0.987	0.000
O65.1 Obstructed labour due to generally contracted pelvis	0.013	0.987	0.000
O65.0 Obstructed labour due to deformed pelvis	0.013	0.987	0.000
O74.9 Complication of anaesthesia during labour and delivery, unspecified	0.013	0.987	0.000
O74.8 Other complications of anaesthesia during labour and delivery	0.013	0.987	0.000
O74.7 Failed or difficult intubation during labour and delivery	0.013	0.987	0.000
O74.6 Other complications of spinal and epidural anaesthesia during labour and delivery	0.013	0.987	0.000
O74.5 Spinal and epidural anaesthesia-induced headache during labour and delivery	0.013	0.987	0.000
O74.4 Toxic reaction to local anaesthesia during labour and delivery	0.013	0.987	0.000
O74.3 Central nervous system complications of anaesthesia during labour and delivery	0.013	0.987	0.000
O74.2 Cardiac complications of anaesthesia during labour and delivery	0.013	0.987	0.000
O74.1 Other pulmonary complications of anaesthesia during labour and delivery	0.013	0.987	0.000
O74.0 Aspiration pneumonitis due to anaesthesia during labour and delivery	0.013	0.987	0.000
O99 Other maternal diseases classifiable elsewhere but complicating pregnancy, childbirth and the puerperium	0.013	0.987	0.000
O61.9 Failed induction of labour, unspecified	0.013	0.987	0.000
O61.8 Other failed induction of labour	0.013	0.987	0.000
O61.1 Failed instrumental induction of labour	0.013	0.987	0.000
D84 Other immunodeficiencies	0.012	0.987	0.000
O61.0 Failed medical induction of labour	0.012	0.987	0.000
O22 Venous complications in pregnancy	0.012	0.988	0.000
O75.9 Complication of labour and delivery, unspecified	0.012	0.988	0.000
O75.5 Delayed delivery after artificial rupture of membranes	0.012	0.988	0.000
O75.4 Other complications of obstetric surgery and procedures	0.012	0.988	0.000
O75.3 Other infection during labour	0.012	0.988	0.000
O75.1 Shock during or following labour and delivery	0.012	0.988	0.000
O68.8 Labour and delivery complicated by other evidence of foetal stress	0.012	0.988	0.000
O62 Abnormalities of forces of labour	0.012	0.988	0.000
O80.0 Spontaneous vertex delivery	0.012	0.988	0.000
O96.9 Death from unspecified obstetric cause	0.012	0.988	0.000
O96.1 Death from indirect obstetric cause	0.012	0.988	0.000
O96.0 Death from direct obstetric cause	0.012	0.988	0.000
O97.9 Death from sequelae of obstetric cause, unspecified	0.012	0.988	0.000
O97.1 Death from sequelae of indirect obstetric cause	0.012	0.988	0.000
O97.0 Death from sequelae of direct obstetric cause	0.012	0.988	0.000
O98.9 Unspecified maternal infectious or parasitic disease complicating pregnancy, childbirth and the puerperium	0.012	0.988	0.000
O98.8 Other maternal infectious and parasitic diseases complicating pregnancy, childbirth and the puerperium	0.012	0.988	0.000
O98.7 Human immunodeficiency [HIV] disease complicating pregnancy, childbirth and the puerperium	0.012	0.988	0.000
O98.6 Protozoal diseases complicating pregnancy, childbirth and the puerperium	0.012	0.988	0.000
O98.5 Other viral diseases complicating pregnancy, childbirth and the puerperium	0.012	0.988	0.000
O98.4 Viral hepatitis complicating pregnancy, childbirth and the puerperium	0.012	0.988	0.000
O98.3 Other infections with a predominantly sexual mode of transmission complicating pregnancy, childbirth and the puerperium	0.012	0.988	0.000
O98.2 Gonorrhoea complicating pregnancy, childbirth and the puerperium	0.012	0.988	0.000
O98.1 Syphilis complicating pregnancy, childbirth and the puerperium	0.012	0.988	0.000
O98.0 Tuberculosis complicating pregnancy, childbirth and the puerperium	0.012	0.988	0.000
D80 Immunodeficiency with predominantly antibody defects	0.012	0.988	0.000
J43.2 Centrilobular emphysema	0.000	0.988	0.012
O75.2 Pyrexia during labour, not elsewhere classified	0.012	0.988	0.000
D74.9 Methaemoglobinaemia, unspecified	0.012	0.988	0.000
D74.8 Other methaemoglobinaemias	0.012	0.988	0.000
D74.0 Congenital methaemoglobinaemia	0.012	0.988	0.000
D50-D53 Nutritional anaemias	0.012	0.988	0.000
O72.1 Other immediate postpartum haemorrhage	0.012	0.988	0.000
O29 Complications of anaesthesia during pregnancy	0.012	0.988	0.000
O25 Malnutrition in pregnancy	0.012	0.988	0.000
O00-O08 Pregnancy with abortive outcome	0.012	0.988	0.000
O75.8 Other specified complications of labour and delivery	0.012	0.988	0.000
O75.6 Delayed delivery after spontaneous or unspecified rupture of membranes	0.012	0.988	0.000
J45 Asthma	0.000	0.988	0.012
O24 Diabetes mellitus in pregnancy	0.011	0.988	0.000
O67.8 Other intrapartum haemorrhage	0.011	0.989	0.000
O67.0 Intrapartum haemorrhage with coagulation defect	0.011	0.989	0.000
O71.9 Obstetric trauma, unspecified	0.011	0.989	0.000
O71.7 Obstetric haematoma of pelvis	0.011	0.989	0.000
O71.6 Obstetric damage to pelvic joints and ligaments	0.011	0.989	0.000
O71.5 Other obstetric injury to pelvic organs	0.011	0.989	0.000
O71.3 Obstetric laceration of cervix	0.011	0.989	0.000
O71.2 Postpartum inversion of uterus	0.011	0.989	0.000
O71.1 Rupture of uterus during labour	0.011	0.989	0.000
O71.0 Rupture of uterus before onset of labour	0.011	0.989	0.000
O72.3 Postpartum coagulation defects	0.011	0.989	0.000
O28 Abnormal findings on antenatal screening of mother	0.011	0.989	0.000
O75.0 Maternal distress during labour and delivery	0.011	0.989	0.000
O99.1 Other diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism complicating pregnancy, childbirth and the puerperium	0.011	0.989	0.000
O12 Gestational [pregnancy-induced] oedema and proteinuria without hypertension	0.011	0.989	0.000
O26 Maternal care for other conditions predominantly related to pregnancy	0.011	0.989	0.000
O71.8 Other specified obstetric trauma	0.011	0.989	0.000
D62 Acute posthaemorrhagic anaemia	0.010	0.989	0.000
D72.1 Eosinophilia	0.010	0.989	0.000
O68.3 Labour and delivery complicated by biochemical evidence of foetal stress	0.011	0.989	0.000
D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified	0.010	0.989	0.000
D89.3 Immune reconstitution syndrome	0.010	0.989	0.000
D89.1 Cryoglobulinaemia	0.010	0.989	0.000
D89.0 Polyclonal hypergammaglobulinaemia	0.010	0.989	0.000
D75.8 Other specified diseases of blood and blood-forming organs	0.010	0.989	0.000
O69.9 Labour and delivery complicated by cord complication, unspecified	0.010	0.989	0.000
O69.8 Labour and delivery complicated by other cord complications	0.010	0.990	0.000
D76.2 Haemophagocytic syndrome, infection-associated	0.010	0.990	0.000
D76.1 Haemophagocytic lymphohistiocytosis	0.010	0.990	0.000
D76.0 Langerhans' cell histiocytosis, not elsewhere classified	0.010	0.990	0.000
O72.0 Third-stage haemorrhage	0.010	0.990	0.000
O10 Pre-existing hypertension complicating pregnancy, childbirth and the puerperium	0.010	0.990	0.000
D75.1 Secondary polycythaemia	0.010	0.990	0.000
O63.0 Prolonged first stage (of labour)	0.010	0.990	0.000
O23.5 Infections of the genital tract in pregnancy	0.010	0.990	0.000
O71.4 Obstetric high vaginal laceration alone	0.010	0.990	0.000
O23.4 Unspecified infection of urinary tract in pregnancy	0.010	0.990	0.000
O15 Eclampsia	0.010	0.990	0.000
O11 Pre-existing hypertensive disorder with superimposed proteinuria	0.010	0.990	0.000
O26.2 Pregnancy care of habitual aborter	0.010	0.990	0.000
D64.8 Other specified anaemias	0.010	0.990	0.000
O99.5 Diseases of the respiratory system complicating pregnancy, childbirth and the puerperium	0.010	0.990	0.000
O22.4 Haemorrhoids in pregnancy	0.010	0.990	0.000
S66.3 Injury of extensor muscle and tendon of other finger at wrist and hand level	0.010	0.990	0.000
D81.9 Combined immunodeficiency, unspecified	0.009	0.990	0.000
D81.8 Other combined immunodeficiencies	0.009	0.990	0.000
D81.7 Major histocompatibility complex class II deficiency	0.009	0.990	0.000
D81.6 Major histocompatibility complex class I deficiency	0.009	0.990	0.000
D81.5 Purine nucleoside phosphorylase [PNP] deficiency	0.009	0.990	0.000
D81.4 Nezelof's syndrome	0.009	0.990	0.000
D81.3 Adenosine deaminase [ADA] deficiency	0.009	0.990	0.000
D81.2 Severe combined immunodeficiency [SCID] with low or normal B-cell numbers	0.009	0.990	0.000
D81.1 Severe combined immunodeficiency [SCID] with low T- and B-cell numbers	0.009	0.990	0.000
D81.0 Severe combined immunodeficiency [SCID] with reticular dysgenesis	0.009	0.990	0.000
D82.9 Immunodeficiency associated with major defect, unspecified	0.009	0.990	0.000
D82.8 Immunodeficiency associated with other specified major defects	0.009	0.990	0.000
D82.4 Hyperimmunoglobulin E [IgE] syndrome	0.009	0.990	0.000
D82.3 Immunodeficiency following hereditary defective response to Epstein-Barr virus	0.009	0.990	0.000
D82.2 Immunodeficiency with short-limbed stature	0.009	0.990	0.000
D82.1 Di George's syndrome	0.009	0.990	0.000
D82.0 Wiskott-Aldrich syndrome	0.009	0.990	0.000
D83.9 Common variable immunodeficiency, unspecified	0.009	0.990	0.000
D83.8 Other common variable immunodeficiencies	0.009	0.990	0.000
D83.2 Common variable immunodeficiency with autoantibodies to B- or T-cells	0.009	0.990	0.000
D83.1 Common variable immunodeficiency with predominant immunoregulatory T-cell disorders	0.009	0.990	0.000
D83.0 Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function	0.009	0.990	0.000
D64.4 Congenital dyserythropoietic anaemia	0.009	0.990	0.000
D64.3 Other sideroblastic anaemias	0.009	0.990	0.000
D64.2 Secondary sideroblastic anaemia due to drugs and toxins	0.009	0.990	0.000
D64.1 Secondary sideroblastic anaemia due to disease	0.009	0.990	0.000
D64.0 Hereditary sideroblastic anaemia	0.009	0.990	0.000
D73.5 Infarction of spleen	0.009	0.990	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations