TreeWAS – Variant ID: rs13008689

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

Hierarchical visualisation How to interpret this figure?

Click here to show this figure without filtering.

Click on a node to zoom (except terminal nodes).

Download this figure in format

Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
N12 Tubulo-interstitial nephritis, not specified as acute or chronic	0.089	0.911	0.000
M25.76 Osteophyte (Lower leg)	0.000	0.980	0.020
M79.09 Rheumatism, unspecified (Site unspecified)	0.018	0.982	0.000
N10-N16 Renal tubulo-interstitial diseases	0.016	0.984	0.000
M24.16 Other articular cartilage disorders (Lower leg)	0.000	0.985	0.015
N11 Chronic tubulo-interstitial nephritis	0.014	0.986	0.000
N11.9 Chronic tubulo-interstitial nephritis, unspecified	0.013	0.987	0.000
N14 Drug- and heavy-metal-induced tubulo-interstitial and tubular conditions	0.013	0.987	0.000
H71 Cholesteatoma of middle ear	0.000	0.988	0.012
Q66 Congenital deformities of feet	0.012	0.988	0.000
N16 Renal tubulo-interstitial disorders in diseases classified elsewhere	0.011	0.988	0.000
H92.0 Otalgia	0.000	0.989	0.011
Q66.6 Other congenital valgus deformities of feet	0.011	0.989	0.000
Q66.8 Other congenital deformities of feet	0.011	0.989	0.000
B97.7 Papillomavirus as the cause of diseases classified to other chapters	0.011	0.989	0.000
N14.1 Nephropathy induced by other drugs, medicaments and biological substances	0.011	0.989	0.000
N15 Other renal tubulo-interstitial diseases	0.011	0.989	0.000
Q66.3 Other congenital varus deformities of feet	0.010	0.990	0.000
Q66.2 Metatarsus varus	0.010	0.990	0.000
N11.0 Nonobstructive reflux-associated chronic pyelonephritis	0.010	0.990	0.000
N11.8 Other chronic tubulo-interstitial nephritis	0.010	0.990	0.000
M79.0 Rheumatism, unspecified	0.010	0.990	0.000
N14.4 Toxic nephropathy, not elsewhere classified	0.009	0.990	0.000
N14.3 Nephropathy induced by heavy metals	0.009	0.990	0.000
N14.2 Nephropathy induced by unspecified drug, medicament or biological substance	0.009	0.990	0.000
N14.0 Analgesic nephropathy	0.009	0.990	0.000
M24.1 Other articular cartilage disorders	0.000	0.991	0.009
Q66.7 Pes cavus	0.009	0.991	0.000
Q66.9 Congenital deformity of feet, unspecified	0.009	0.991	0.000
T93.3 Sequelae of dislocation, sprain and strain of lower limb	0.009	0.991	0.000
N11.1 Chronic obstructive pyelonephritis	0.009	0.991	0.000
Q66.5 Congenital pes planus	0.008	0.991	0.000
Q66.4 Talipes calcaneovalgus	0.008	0.991	0.000
Q66.1 Talipes calcaneovarus	0.008	0.991	0.000
M79.08 Rheumatism, unspecified (Other)	0.009	0.991	0.000
N16.8 Renal tubulo-interstitial disorders in other diseases classified elsewhere	0.008	0.991	0.000
N16.5 Renal tubulo-interstitial disorders in transplant rejection	0.008	0.991	0.000
N16.4 Renal tubulo-interstitial disorders in systemic connective tissue disorders	0.008	0.991	0.000
N16.3 Renal tubulo-interstitial disorders in metabolic diseases	0.008	0.991	0.000
N16.2 Renal tubulo-interstitial disorders in blood diseases and disorders involving the immune mechanism	0.008	0.991	0.000
N16.1 Renal tubulo-interstitial disorders in neoplastic diseases	0.008	0.991	0.000
N16.0 Renal tubulo-interstitial disorders in infectious and parasitic diseases classified elsewhere	0.008	0.991	0.000
H92 Otalgia and effusion of ear	0.000	0.991	0.009
Q66.0 Talipes equinovarus	0.008	0.992	0.000
H92.1 Otorrhoea	0.000	0.992	0.008
M24.11 Other articular cartilage disorders (Shoulder region)	0.000	0.992	0.008
M79.00 Rheumatism, unspecified (Multiple sites)	0.008	0.992	0.000
T98.3 Sequelae of complications of surgical and medical care, not elsewhere classified	0.008	0.992	0.000
N15.1 Renal and perinephric abscess	0.008	0.992	0.000
M24.17 Other articular cartilage disorders (Ankle and foot)	0.000	0.992	0.008
N15.8 Other specified renal tubulo-interstitial diseases	0.008	0.992	0.000
N15.0 Balkan nephropathy	0.008	0.992	0.000
Y51.7 Beta-Adrenoreceptor antagonists, not elsewhere classified	0.000	0.992	0.008
M79.07 Rheumatism, unspecified (Ankle and foot)	0.007	0.992	0.000
M79.05 Rheumatism, unspecified (Pelvic region and thigh)	0.007	0.992	0.000
M79.04 Rheumatism, unspecified (Hand)	0.007	0.992	0.000
M79.03 Rheumatism, unspecified (Forearm)	0.007	0.992	0.000
M79.02 Rheumatism, unspecified (Upper arm)	0.007	0.992	0.000
M79.06 Rheumatism, unspecified (Lower leg)	0.007	0.993	0.000
Y88.3 Sequelae of surgical and medical procedures as the cause of abnormal reaction of the patient or of later complication, without mention of misadventure at the time of the procedure	0.007	0.993	0.000
M24.15 Other articular cartilage disorders (Pelvic region and thigh)	0.000	0.993	0.007
T93 Sequelae of injuries of lower limb	0.007	0.993	0.000
M24.19 Other articular cartilage disorders (Site unspecified)	0.000	0.993	0.007
M24.18 Other articular cartilage disorders (Other)	0.000	0.993	0.007
M24.14 Other articular cartilage disorders (Hand)	0.000	0.993	0.007
M24.12 Other articular cartilage disorders (Upper arm)	0.000	0.993	0.007
M24.10 Other articular cartilage disorders (Multiple sites)	0.000	0.993	0.007
T98 Sequelae of other and unspecified effects of external causes	0.007	0.993	0.000
N10 Acute tubulo-interstitial nephritis	0.007	0.993	0.000
T93.1 Sequelae of fracture of femur	0.007	0.993	0.000
M79.01 Rheumatism, unspecified (Shoulder region)	0.006	0.993	0.000
L57.8 Other skin changes due to chronic exposure to nonionising radiation	0.007	0.993	0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes	0.007	0.993	0.000
N15.9 Renal tubulo-interstitial disease, unspecified	0.006	0.994	0.000
T91 Sequelae of injuries of neck and trunk	0.006	0.994	0.000
H92.2 Otorrhagia	0.000	0.994	0.006
I69.4 Sequelae of stroke, not specified as haemorrhage or infarction	0.000	0.994	0.006
T91.8 Sequelae of other specified injuries of neck and trunk	0.006	0.994	0.000
I49.9 Cardiac arrhythmia, unspecified	0.000	0.994	0.006
T91.3 Sequelae of injury of spinal cord	0.006	0.994	0.000
T95 Sequelae of burns, corrosions and frostbite	0.006	0.994	0.000
T93.9 Sequelae of unspecified injury of lower limb	0.005	0.994	0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system	0.005	0.995	0.000
T93.6 Sequelae of crushing injury and traumatic amputation of lower limb	0.005	0.995	0.000
T93.4 Sequelae of injury of nerve of lower limb	0.005	0.995	0.000
Y88 Sequelae of surgical and medical care as external cause	0.005	0.995	0.000
T93.2 Sequelae of other fractures of lower limb	0.005	0.995	0.000
T84.6 Infection and inflammatory reaction due to internal fixation device [any site]	0.000	0.995	0.005
T98.2 Sequelae of certain early complications of trauma	0.005	0.995	0.000
T98.0 Sequelae of effects of foreign body entering through natural orifice	0.005	0.995	0.000
M24.13 Other articular cartilage disorders (Forearm)	0.000	0.995	0.005
T97 Sequelae of toxic effects of substances chiefly nonmedicinal as to source	0.005	0.995	0.000
T96 Sequelae of poisoning by drugs, medicaments and biological substances	0.005	0.995	0.000
T94 Sequelae of injuries involving multiple and unspecified body regions	0.005	0.995	0.000
T95.1 Sequelae of burn, corrosion and frostbite of trunk	0.005	0.995	0.000
T90 Sequelae of injuries of head	0.005	0.995	0.000
T91.5 Sequelae of injury of intra-abdominal and pelvic organs	0.005	0.995	0.000
T91.4 Sequelae of injury of intrathoracic organs	0.005	0.995	0.000
T91.0 Sequelae of superficial injury and open wound of neck and trunk	0.005	0.995	0.000
T95.2 Sequelae of burn, corrosion and frostbite of upper limb	0.005	0.995	0.000
T90.5 Sequelae of intracranial injury	0.005	0.995	0.000
T90.1 Sequelae of open wound of head	0.005	0.995	0.000
Q78 Other osteochondrodysplasias	0.005	0.995	0.000
T91.1 Sequelae of fracture of spine	0.004	0.995	0.000
Z40.0 Prophylactic surgery for risk-factors related to malignant neoplasms	0.000	0.996	0.004
T95.8 Sequelae of other specified burn, corrosion and frostbite	0.004	0.996	0.000
Q77 Osteochondrodysplasia with defects of growth of tubular bones and spine	0.004	0.996	0.000
T91.9 Sequelae of unspecified injury of neck and trunk	0.004	0.996	0.000
T95.9 Sequelae of unspecified burn, corrosion and frostbite	0.004	0.996	0.000
T95.4 Sequelae of burn and corrosion classifiable only according to extent of body surface involved	0.004	0.996	0.000
T95.3 Sequelae of burn, corrosion and frostbite of lower limb	0.004	0.996	0.000
T95.0 Sequelae of burn, corrosion and frostbite of head and neck	0.004	0.996	0.000
I69.0 Sequelae of subarachnoid haemorrhage	0.000	0.996	0.004
T90.8 Sequelae of other specified injuries of head	0.004	0.996	0.000
T98.1 Sequelae of other and unspecified effects of external causes	0.004	0.996	0.000
C32.0 Glottis	0.000	0.996	0.004
T93.5 Sequelae of injury of muscle and tendon of lower limb	0.004	0.996	0.000
Y88.0 Sequelae of adverse effects caused by drugs, medicaments and biological substances in therapeutic use	0.004	0.996	0.000
Q68 Other congenital musculoskeletal deformities	0.004	0.996	0.000
Q75 Other congenital malformations of skull and face bones	0.004	0.996	0.000
Q73 Reduction defects of unspecified limb	0.004	0.996	0.000
Q72 Reduction defects of lower limb	0.004	0.996	0.000
Q71 Reduction defects of upper limb	0.004	0.996	0.000
Q70 Syndactyly	0.004	0.996	0.000
Q69 Polydactyly	0.004	0.996	0.000
T93.0 Sequelae of open wound of lower limb	0.004	0.996	0.000
Q76 Congenital malformations of spine and bony thorax	0.004	0.996	0.000
T93.8 Sequelae of other specified injuries of lower limb	0.004	0.996	0.000
Y88.2 Sequelae of adverse incidents associated with medical devices in diagnostic and therapeutic use	0.004	0.996	0.000
T94.0 Sequelae of injuries involving multiple body regions	0.004	0.996	0.000
Q78.0 Osteogenesis imperfecta	0.004	0.996	0.000
I69 Sequelae of cerebrovascular disease	0.000	0.996	0.004
Y88.1 Sequelae of misadventures to patients during surgical and medical procedures	0.004	0.996	0.000
Q79 Congenital malformations of musculoskeletal system, not elsewhere classified	0.004	0.996	0.000
Y85-Y89 Sequelae of external causes of morbidity and mortality	0.004	0.996	0.000
Y51 Drugs primarily affecting the autonomic nervous system	0.000	0.996	0.004
Q65 Congenital deformities of hip	0.004	0.996	0.000
Y85.0 Sequelae of motor-vehicle accident	0.004	0.996	0.000
Q74 Other congenital malformations of limb(s)	0.004	0.996	0.000
I05.2 Mitral stenosis with insufficiency	0.004	0.996	0.000
B97 Viral agents as the cause of diseases classified to other chapters	0.004	0.996	0.000
Q07 Other congenital malformations of nervous system	0.004	0.996	0.000
T90.3 Sequelae of injury of cranial nerves	0.004	0.996	0.000
Q07.0 Arnold-Chiari syndrome	0.004	0.996	0.000
Q77.4 Achondroplasia	0.004	0.996	0.000
Y89 Sequelae of other external causes	0.004	0.996	0.000
Y87.1 Sequelae of assault	0.004	0.996	0.000
I27.8 Other specified pulmonary heart diseases	0.000	0.996	0.004
Y89.9 Sequelae of unspecified external cause	0.004	0.996	0.000
Q00-Q07 Congenital malformations of the nervous system	0.004	0.996	0.000
M81.90 Osteoporosis, unspecified (Multiple sites)	0.004	0.996	0.000
Q78.9 Osteochondrodysplasia, unspecified	0.003	0.996	0.000
Q78.8 Other specified osteochondrodysplasias	0.003	0.996	0.000
Q78.6 Multiple congenital exostoses	0.003	0.996	0.000
Q78.5 Metaphyseal dysplasia	0.003	0.996	0.000
Q78.4 Enchondromatosis	0.003	0.996	0.000
Q78.3 Progressive diaphyseal dysplasia	0.003	0.996	0.000
Q78.2 Osteopetrosis	0.003	0.996	0.000
Q78.1 Polyostotic fibrous dysplasia	0.003	0.996	0.000
Y85 Sequelae of transport accidents	0.003	0.997	0.000
B97.4 Respiratory synctial virus as the cause of diseases classified to other chapters	0.003	0.997	0.000
T94.1 Sequelae of injuries, not specified by body region	0.003	0.997	0.000
Y87 Sequelae of intentional self-harm, assault and events of undetermined intent	0.003	0.997	0.000
Q77.9 Osteochondrodysplasia with defects of growth of tubular bones and spine, unspecified	0.003	0.997	0.000
Q77.8 Other osteochondrodysplasia with defects of growth of tubular bones and spine	0.003	0.997	0.000
Q77.7 Spondyloepiphyseal dysplasia	0.003	0.997	0.000
Q77.6 Chondroectodermal dysplasia	0.003	0.997	0.000
Q77.5 Diastrophic dysplasia	0.003	0.997	0.000
Q77.3 Chondrodysplasia punctata	0.003	0.997	0.000
Q77.2 Short rib syndrome	0.003	0.997	0.000
Q77.1 Thanatophoric short stature	0.003	0.997	0.000
Q77.0 Achondrogenesis	0.003	0.997	0.000
Y51.3 Other parasympatholytics [anticholinergics and antimuscarinics] and spasmolytics, not elsewhere classified	0.000	0.997	0.003
Q76.4 Other congenital malformations of spine, not associated with scoliosis	0.003	0.997	0.000
Q61 Cystic kidney disease	0.003	0.997	0.000
M54.36 Sciatica (Lumbar region)	0.003	0.997	0.000
Y51.9 Other and unspecified drugs primarily affecting the autonomic nervous system	0.000	0.997	0.003
I27.2 Other secondary pulmonary hypertension	0.000	0.997	0.003
Q68.8 Other specified congenital musculoskeletal deformities	0.003	0.997	0.000
Q61.2 Polycystic kidney, adult type	0.003	0.997	0.000
Q68.5 Congenital bowing of long bones of leg, unspecified	0.003	0.997	0.000
Q68.4 Congenital bowing of tibia and fibula	0.003	0.997	0.000
Q68.3 Congenital bowing of femur	0.003	0.997	0.000
Q68.2 Congenital deformity of knee	0.003	0.997	0.000
Q68.1 Congenital deformity of hand	0.003	0.997	0.000
Q68.0 Congenital deformity of sternocleidomastoid muscle	0.003	0.997	0.000
I27.0 Primary pulmonary hypertension	0.000	0.997	0.003
I69.1 Sequelae of intracerebral haemorrhage	0.000	0.997	0.003
T91.2 Sequelae of other fracture of thorax and pelvis	0.003	0.997	0.000
Q69.9 Polydactyly, unspecified	0.003	0.997	0.000
Q69.2 Accessory toe(s)	0.003	0.997	0.000
Q69.1 Accessory thumb(s)	0.003	0.997	0.000
Q69.0 Accessory finger(s)	0.003	0.997	0.000
Q70.9 Syndactyly, unspecified	0.003	0.997	0.000
Q70.4 Polysyndactyly	0.003	0.997	0.000
Q70.3 Webbed toes	0.003	0.997	0.000
Q70.2 Fused toes	0.003	0.997	0.000
Q70.1 Webbed fingers	0.003	0.997	0.000
Q70.0 Fused fingers	0.003	0.997	0.000
Q71.9 Reduction defect of upper limb, unspecified	0.003	0.997	0.000
Q71.8 Other reduction defects of upper limb(s)	0.003	0.997	0.000
Q71.6 Lobster-claw hand	0.003	0.997	0.000
Q71.5 Longitudinal reduction defect of ulna	0.003	0.997	0.000
Q71.4 Longitudinal reduction defect of radius	0.003	0.997	0.000
Q71.3 Congenital absence of hand and finger(s)	0.003	0.997	0.000
Q71.2 Congenital absence of both forearm and hand	0.003	0.997	0.000
Q71.1 Congenital absence of upper arm and forearm with hand present	0.003	0.997	0.000
Q71.0 Congenital complete absence of upper limb(s)	0.003	0.997	0.000
Q72.9 Reduction defect of lower limb, unspecified	0.003	0.997	0.000
Q72.8 Other reduction defects of lower limb(s)	0.003	0.997	0.000
Q72.7 Split foot	0.003	0.997	0.000
Q72.6 Longitudinal reduction defect of fibula	0.003	0.997	0.000
Q72.5 Longitudinal reduction defect of tibia	0.003	0.997	0.000
Q72.4 Longitudinal reduction defect of femur	0.003	0.997	0.000
Q72.3 Congenital absence of foot and toe(s)	0.003	0.997	0.000
Q72.2 Congenital absence of both lower leg and foot	0.003	0.997	0.000
Q72.1 Congenital absence of thigh and lower leg with foot present	0.003	0.997	0.000
Q72.0 Congenital complete absence of lower limb(s)	0.003	0.997	0.000
Q73.8 Other reduction defects of unspecified limb(s)	0.003	0.997	0.000
Q73.1 Phocomelia, unspecified limb(s)	0.003	0.997	0.000
Q73.0 Congenital absence of unspecified limb(s)	0.003	0.997	0.000
Q75.9 Congenital malformation of skull and face bones, unspecified	0.003	0.997	0.000
Q75.8 Other specified congenital malformations of skull and face bones	0.003	0.997	0.000
Q75.5 Oculomandibular dysostosis	0.003	0.997	0.000
Q75.4 Mandibulofacial dysostosis	0.003	0.997	0.000
Q75.3 Macrocephaly	0.003	0.997	0.000
Q75.2 Hypertelorism	0.003	0.997	0.000
Q75.1 Craniofacial dysostosis	0.003	0.997	0.000
Q75.0 Craniosynostosis	0.003	0.997	0.000
Q05 Spina bifida	0.003	0.997	0.000
Q67 Congenital musculoskeletal deformities of head, face, spine and chest	0.003	0.997	0.000
Q76.9 Congenital malformation of bony thorax, unspecified	0.003	0.997	0.000
Q76.8 Other congenital malformations of bony thorax	0.003	0.997	0.000
Q76.7 Congenital malformation of sternum	0.003	0.997	0.000
Q76.6 Other congenital malformations of ribs	0.003	0.997	0.000
Q76.5 Cervical rib	0.003	0.997	0.000
Q76.3 Congenital scoliosis due to congenital bony malformation	0.003	0.997	0.000
Q76.2 Congenital spondylolisthesis	0.003	0.997	0.000
Q07.8 Other specified congenital malformations of nervous system	0.003	0.997	0.000
Q61.5 Medullary cystic kidney	0.003	0.997	0.000
Q76.1 Klippel-Feil syndrome	0.003	0.997	0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities	0.003	0.997	0.000
Q74.1 Congenital malformation of knee	0.003	0.997	0.000
T92.9 Sequelae of unspecified injury of upper limb	0.003	0.997	0.000
C32.9 Larynx, unspecified	0.000	0.997	0.003
I69.8 Sequelae of other and unspecified cerebrovascular diseases	0.000	0.997	0.003
I27 Other pulmonary heart diseases	0.000	0.997	0.003
Q61.0 Congenital single renal cyst	0.003	0.997	0.000
Q79.9 Congenital malformation of musculoskeletal system, unspecified	0.003	0.997	0.000
Q79.5 Other congenital malformations of abdominal wall	0.003	0.997	0.000
Q79.4 Prune belly syndrome	0.003	0.997	0.000
Q79.3 Gastroschisis	0.003	0.997	0.000
Q79.2 Exomphalos	0.003	0.997	0.000
Q79.1 Other congenital malformations of diaphragm	0.003	0.997	0.000
Q79.0 Congenital diaphragmatic hernia	0.003	0.997	0.000
Q85.0 Neurofibromatosis (nonmalignant)	0.003	0.997	0.000
Q06 Other congenital malformations of spinal cord	0.003	0.997	0.000
T92 Sequelae of injuries of upper limb	0.003	0.997	0.000
B97.1 Enterovirus as the cause of diseases classified to other chapters	0.003	0.997	0.000
Y51.8 Centrally acting and adrenergic-neuron-blocking agents, not elsewhere classified	0.000	0.997	0.003
Y51.4 Predominantly Alpha-adrenoreceptor agonists, not elsewhere classified	0.000	0.997	0.003
Y51.2 Ganglionic blocking drugs, not elsewhere classified	0.000	0.997	0.003
Y51.1 Other parasympathomimetics [cholinergics]	0.000	0.997	0.003
Y51.0 Anticholinesterase agents	0.000	0.997	0.003
Q65.9 Congenital deformity of hip, unspecified	0.003	0.997	0.000
Q65.6 Unstable hip	0.003	0.997	0.000
Q65.5 Congenital subluxation of hip, unspecified	0.003	0.997	0.000
Q65.4 Congenital subluxation of hip, bilateral	0.003	0.997	0.000
Q65.3 Congenital subluxation of hip, unilateral	0.003	0.997	0.000
Q65.1 Congenital dislocation of hip, bilateral	0.003	0.997	0.000
Q65.0 Congenital dislocation of hip, unilateral	0.003	0.997	0.000
T90.9 Sequelae of unspecified injury of head	0.003	0.997	0.000
Q74.9 Unspecified congenital malformation of limb(s)	0.003	0.997	0.000
Q74.8 Other specified congenital malformations of limb(s)	0.003	0.997	0.000
Q74.3 Arthrogryposis multiplex congenita	0.003	0.997	0.000
C32 Malignant neoplasm of larynx	0.000	0.997	0.003
Q65.2 Congenital dislocation of hip, unspecified	0.003	0.997	0.000
M46.99 Inflammatory spondylopathy, unspecified (Site unspecified)	0.000	0.997	0.003
B97.6 Parvovirus as the cause of diseases classified to other chapters	0.003	0.997	0.000
B97.5 Reovirus as the cause of diseases classified to other chapters	0.003	0.997	0.000
B97.3 Retrovirus as the cause of diseases classified to other chapters	0.003	0.997	0.000
B97.2 Coronavirus as the cause of diseases classified to other chapters	0.003	0.997	0.000
B97.0 Adenovirus as the cause of diseases classified to other chapters	0.003	0.997	0.000
Q05.9 Spina bifida, unspecified	0.003	0.997	0.000
Q07.9 Congenital malformation of nervous system, unspecified	0.003	0.997	0.000
Q79.6 Ehlers-Danlos syndrome	0.003	0.997	0.000
Q60-Q64 Congenital malformations of the urinary system	0.003	0.997	0.000
Q76.0 Spina bifida occulta	0.003	0.997	0.000
Y89.1 Sequelae of war operations	0.003	0.997	0.000
Y89.0 Sequelae of legal intervention	0.003	0.997	0.000
Q90-Q99 Chromosomal abnormalities, not elsewhere classified	0.003	0.997	0.000
Q03 Congenital hydrocephalus	0.003	0.997	0.000
Q01 Encephalocele	0.003	0.997	0.000
Q00 Anencephaly and similar malformations	0.003	0.997	0.000
Q02 Microcephaly	0.003	0.997	0.000
T90.4 Sequelae of injury of eye and orbit	0.003	0.997	0.000
I51.7 Cardiomegaly	0.000	0.997	0.003
Q79.8 Other congenital malformations of musculoskeletal system	0.003	0.997	0.000
M25.74 Osteophyte (Hand)	0.003	0.997	0.000
Q04 Other congenital malformations of brain	0.003	0.997	0.000
Q05.4 Unspecified spina bifida with hydrocephalus	0.003	0.997	0.000
T90.0 Sequelae of superficial injury of head	0.002	0.997	0.000
Q85 Phakomatoses, not elsewhere classified	0.003	0.997	0.000
Q61.4 Renal dysplasia	0.003	0.997	0.000
Q74.0 Other congenital malformations of upper limb(s), including shoulder girdle	0.002	0.997	0.000
M66.24 Spontaneous rupture of extensor tendons (Hand)	0.003	0.997	0.000
Q61.8 Other cystic kidney diseases	0.003	0.997	0.000
Q61.1 Polycystic kidney, infantile type	0.003	0.997	0.000
Y51.5 Predominantly Beta-adrenoreceptor agonists, not elsewhere classified	0.000	0.997	0.003
Q05.7 Lumbar spina bifida without hydrocephalus	0.003	0.997	0.000
Q06.8 Other specified congenital malformations of spinal cord	0.003	0.997	0.000
Y51.6 @-Adrenoreceptor antagonists, not elsewhere classified	0.000	0.997	0.002
Q35-Q37 Cleft lip and cleft palate	0.003	0.997	0.000
Q05.8 Sacral spina bifida without hydrocephalus	0.002	0.997	0.000
Q05.6 Thoracic spina bifida without hydrocephalus	0.002	0.997	0.000
Q05.5 Cervical spina bifida without hydrocephalus	0.002	0.997	0.000
Q05.3 Sacral spina bifida with hydrocephalus	0.002	0.997	0.000
Q05.2 Lumbar spina bifida with hydrocephalus	0.002	0.997	0.000
Q05.1 Thoracic spina bifida with hydrocephalus	0.002	0.997	0.000
Q05.0 Cervical spina bifida with hydrocephalus	0.002	0.997	0.000
Q74.2 Other congenital malformations of lower limb(s), including pelvic girdle	0.002	0.997	0.000
Q67.8 Other congenital deformities of chest	0.002	0.997	0.000
Q67.7 Pectus carinatum	0.002	0.997	0.000
Q67.4 Other congenital deformities of skull, face and jaw	0.002	0.997	0.000
Q67.3 Plagiocephaly	0.002	0.997	0.000
Q67.2 Dolichocephaly	0.002	0.997	0.000
Q67.1 Compression facies	0.002	0.997	0.000
Q67.0 Facial asymmetry	0.002	0.997	0.000
D50.0 Iron deficiency anaemia secondary to blood loss (chronic)	0.003	0.997	0.000
Q65.8 Other congenital deformities of hip	0.002	0.997	0.000
Q61.9 Cystic kidney disease, unspecified	0.002	0.997	0.000
Q99 Other chromosome abnormalities, not elsewhere classified	0.002	0.997	0.000
Q80-Q89 Other congenital malformations	0.003	0.997	0.000
Q61.3 Polycystic kidney, unspecified	0.003	0.997	0.000
Q85.8 Other phakomatoses, not elsewhere classified	0.002	0.997	0.000
Q30-Q34 Congenital malformations of the respiratory system	0.002	0.997	0.000
Y87.2 Sequelae of events of undetermined intent	0.002	0.997	0.000
Q90 Down's syndrome	0.002	0.997	0.000
I27.1 Kyphoscoliotic heart disease	0.000	0.997	0.002
T92.0 Sequelae of open wound of upper limb	0.002	0.997	0.000
Q06.9 Congenital malformation of spinal cord, unspecified	0.002	0.998	0.000
Q06.4 Hydromyelia	0.002	0.998	0.000
Q06.3 Other congenital cauda equina malformations	0.002	0.998	0.000
Q06.2 Diastematomyelia	0.002	0.998	0.000
Q06.1 Hypoplasia and dysplasia of spinal cord	0.002	0.998	0.000
Q06.0 Amyelia	0.002	0.998	0.000
Z40 Prophylactic surgery	0.000	0.998	0.002
I05.9 Mitral valve disease, unspecified	0.002	0.998	0.000
N84.3 Polyp of vulva	0.002	0.998	0.000
I69.2 Sequelae of other nontraumatic intracranial haemorrhage	0.000	0.998	0.002
T92.4 Sequelae of injury of nerve of upper limb	0.002	0.998	0.000
Y87.0 Sequelae of intentional self-harm	0.002	0.998	0.000
Q96 Turner's syndrome	0.002	0.998	0.000
C32.8 Overlapping lesion of larynx	0.000	0.998	0.002
C32.3 Laryngeal cartilage	0.000	0.998	0.002
C32.2 Subglottis	0.000	0.998	0.002
R50.8 Other specified fever	0.002	0.998	0.000
C32.1 Supraglottis	0.000	0.998	0.002
I69.3 Sequelae of cerebral infarction	0.000	0.998	0.002
Q99.8 Other specified chromosome abnormalities	0.002	0.998	0.000
R79.0 Abnormal level of blood mineral	0.002	0.998	0.000
T92.2 Sequelae of fracture at wrist and hand level	0.002	0.998	0.000
Q97 Other sex chromosome abnormalities, female phenotype, not elsewhere classified	0.002	0.998	0.000
Q95 Balanced rearrangements and structural markers, not elsewhere classified	0.002	0.998	0.000
Q93 Monosomies and deletions from the autosomes, not elsewhere classified	0.002	0.998	0.000
Q92 Other trisomies and partial trisomies of the autosomes, not elsewhere classified	0.002	0.998	0.000
Q91 Edwards' syndrome and Patau's syndrome	0.002	0.998	0.000
Q00.2 Iniencephaly	0.002	0.998	0.000
Q00.1 Craniorachischisis	0.002	0.998	0.000
Q00.0 Anencephaly	0.002	0.998	0.000
Q01.9 Encephalocele, unspecified	0.002	0.998	0.000
Q01.8 Encephalocele of other sites	0.002	0.998	0.000
Q01.2 Occipital encephalocele	0.002	0.998	0.000
Q01.1 Nasofrontal encephalocele	0.002	0.998	0.000
Q01.0 Frontal encephalocele	0.002	0.998	0.000
Q03.9 Congenital hydrocephalus, unspecified	0.002	0.998	0.000
Q03.8 Other congenital hydrocephalus	0.002	0.998	0.000
Q03.1 Atresia of foramina of Magendie and Luschka	0.002	0.998	0.000
Q03.0 Malformations of aqueduct of Sylvius	0.002	0.998	0.000
Q67.6 Pectus excavatum	0.002	0.998	0.000
H65-H75 Diseases of middle ear and mastoid	0.000	0.998	0.002
Q37 Cleft palate with cleft lip	0.002	0.998	0.000
Q04.9 Congenital malformation of brain, unspecified	0.002	0.998	0.000
Q04.8 Other specified congenital malformations of brain	0.002	0.998	0.000
Q04.5 Megalencephaly	0.002	0.998	0.000
Q04.4 Septo-optic dysplasia	0.002	0.998	0.000
Q04.3 Other reduction deformities of brain	0.002	0.998	0.000
Q04.2 Holoprosencephaly	0.002	0.998	0.000
Q04.1 Arhinencephaly	0.002	0.998	0.000
Q04.0 Congenital malformations of corpus callosum	0.002	0.998	0.000
I05 Rheumatic mitral valve diseases	0.002	0.998	0.000
Q98 Other sex chromosome abnormalities, male phenotype, not elsewhere classified	0.002	0.998	0.000
T92.8 Sequelae of other specified injuries of upper limb	0.002	0.998	0.000
Q64 Other congenital malformations of urinary system	0.002	0.998	0.000
Y86 Sequelae of other accidents	0.002	0.998	0.000
Q90.9 Down's syndrome, unspecified	0.002	0.998	0.000
Q62 Congenital obstructive defects of renal pelvis and congenital malformations of ureter	0.002	0.998	0.000
B02.3 Zoster ocular disease	0.000	0.998	0.002
N88.2 Stricture and stenosis of cervix uteri	0.002	0.998	0.000
Q85.1 Tuberous sclerosis	0.002	0.998	0.000
Z40.9 Prophylactic surgery, unspecified	0.000	0.998	0.002
Q04.6 Congenital cerebral cysts	0.002	0.998	0.000
Q63 Other congenital malformations of kidney	0.002	0.998	0.000
Q36 Cleft lip	0.002	0.998	0.000
Q35 Cleft palate	0.002	0.998	0.000
R10.0 Acute abdomen	0.002	0.998	0.000
Z40.8 Other prophylactic surgery	0.000	0.998	0.002
H02.3 Blepharochalasis	0.000	0.998	0.002
H70.9 Mastoiditis, unspecified	0.000	0.998	0.002
H91.1 Presbycusis	0.000	0.998	0.002
H70 Mastoiditis and related conditions	0.000	0.998	0.002
H69.9 Eustachian tube disorder, unspecified	0.000	0.998	0.002
Q67.5 Congenital deformity of spine	0.002	0.998	0.001
Q99.9 Chromosomal abnormality, unspecified	0.002	0.998	0.000
Q99.2 Fragile X chromosome	0.002	0.998	0.000
Q99.1 46,XX true hermaphrodite	0.002	0.998	0.000
Q99.0 Chimera 46,XX/46,XY	0.002	0.998	0.000
Q86 Congenital malformation syndromes due to known exogenous causes, not elsewhere classified	0.002	0.998	0.000
Q84 Other congenital malformations of integument	0.002	0.998	0.000
Q81 Epidermolysis bullosa	0.002	0.998	0.000
Q80 Congenital ichthyosis	0.002	0.998	0.000
Q96.9 Turner's syndrome, unspecified	0.002	0.998	0.000
Q34 Other congenital malformations of respiratory system	0.002	0.998	0.000
Q33 Congenital malformations of lung	0.002	0.998	0.000
Q32 Congenital malformations of trachea and bronchus	0.002	0.998	0.000
Q31 Congenital malformations of larynx	0.002	0.998	0.000
Q30 Congenital malformations of nose	0.002	0.998	0.000
Q37.9 Unspecified cleft palate with unilateral cleft lip	0.002	0.998	0.000
Q90.2 Trisomy 21, translocation	0.002	0.998	0.000
Q90.1 Trisomy 21, mosaicism (mitotic nondisjunction)	0.002	0.998	0.000
Q90.0 Trisomy 21, meiotic nondisjunction	0.002	0.998	0.000
H69 Other disorders of Eustachian tube	0.000	0.998	0.002
Q87 Other specified congenital malformation syndromes affecting multiple systems	0.002	0.998	0.000
Q63.9 Congenital malformation of kidney, unspecified	0.002	0.998	0.000
Q96.8 Other variants of Turner's syndrome	0.002	0.998	0.000
Q96.4 Mosaicism, 45,X/other cell line(s) with abnormal sex chromosome	0.002	0.998	0.000
Q96.3 Mosaicism, 45,X/46,XX or XY	0.002	0.998	0.000
Q96.2 Karyotype 46,X with abnormal sex chromosome, except iso (Xq)	0.002	0.998	0.000
Q96.1 Karyotype 46,X iso (Xq)	0.002	0.998	0.000
Q96.0 Karyotype 45,X	0.002	0.998	0.000
Q60 Renal agenesis and other reduction defects of kidney	0.002	0.998	0.000
Q83 Congenital malformations of breast	0.002	0.998	0.000
D44.6 Carotid body	0.002	0.998	0.000
D44.1 Adrenal gland	0.002	0.998	0.000
Q62.1 Atresia and stenosis of ureter	0.002	0.998	0.000
Q87.8 Other specified congenital malformation syndromes, not elsewhere classified	0.002	0.998	0.000
Q91.7 Patau's syndrome, unspecified	0.002	0.998	0.000
Q91.6 Trisomy 13, translocation	0.002	0.998	0.000
Q91.5 Trisomy 13, mosaicism (mitotic nondisjunction)	0.002	0.998	0.000
Q91.4 Trisomy 13, meiotic nondisjunction	0.002	0.998	0.000
Q91.3 Edwards' syndrome, unspecified	0.002	0.998	0.000
Q91.2 Trisomy 18, translocation	0.002	0.998	0.000
Q91.1 Trisomy 18, mosaicism (mitotic nondisjunction)	0.002	0.998	0.000
Q91.0 Trisomy 18, meiotic nondisjunction	0.002	0.998	0.000
Q92.9 Trisomy and partial trisomy of autosomes, unspecified	0.002	0.998	0.000
Q92.8 Other specified trisomies and partial trisomies of autosomes	0.002	0.998	0.000
Q92.7 Triploidy and polyploidy	0.002	0.998	0.000
Q92.6 Extra marker chromosomes	0.002	0.998	0.000
Q92.5 Duplications with other complex rearrangements	0.002	0.998	0.000
Q92.4 Duplications seen only at prometaphase	0.002	0.998	0.000
Q92.3 Minor partial trisomy	0.002	0.998	0.000
Q92.2 Major partial trisomy	0.002	0.998	0.000
Q92.1 Whole chromosome trisomy, mosaicism (mitotic nondisjunction)	0.002	0.998	0.000
Q92.0 Whole chromosome trisomy, meiotic nondisjunction	0.002	0.998	0.000
Q93.9 Deletion from autosomes, unspecified	0.002	0.998	0.000
Q93.8 Other deletions from the autosomes	0.002	0.998	0.000
Q93.7 Deletions with other complex rearrangements	0.002	0.998	0.000
Q93.6 Deletions seen only at prometaphase	0.002	0.998	0.000
Q93.5 Other deletions of part of a chromosome	0.002	0.998	0.000
Q93.4 Deletion of short arm of chromosome 5	0.002	0.998	0.000
Q93.3 Deletion of short arm of chromosome 4	0.002	0.998	0.000
Q93.2 Chromosome replaced with ring or dicentric	0.002	0.998	0.000
Q93.1 Whole chromosome monosomy, mosaicism (mitotic nondisjunction)	0.002	0.998	0.000
Q93.0 Whole chromosome monosomy, meiotic nondisjunction	0.002	0.998	0.000
Q95.9 Balanced rearrangement and structural marker, unspecified	0.002	0.998	0.000
Q95.8 Other balanced rearrangements and structural markers	0.002	0.998	0.000
Q95.5 Individuals with autosomal fragile site	0.002	0.998	0.000
Q95.4 Individuals with marker heterochromatin	0.002	0.998	0.000
Q95.3 Balanced sex/autosomal rearrangement in abnormal individual	0.002	0.998	0.000
Q95.2 Balanced autosomal rearrangement in abnormal individual	0.002	0.998	0.000
Q95.1 Chromosome inversion in normal individual	0.002	0.998	0.000
Q95.0 Balanced translocation and insertion in normal individual	0.002	0.998	0.000
Q97.9 Sex chromosome abnormality, female phenotype, unspecified	0.002	0.998	0.000
Q97.8 Other specified sex chromosome abnormalities, female phenotype	0.002	0.998	0.000
Q97.3 Female with 46,XY karyotype	0.002	0.998	0.000
Q97.2 Mosaicism, lines with various numbers of X chromosomes	0.002	0.998	0.000
Q97.1 Female with more than three X chromosomes	0.002	0.998	0.000
Q97.0 Karyotype 47,XXX	0.002	0.998	0.000
R30.9 Painful micturition, unspecified	0.002	0.998	0.000
T92.1 Sequelae of fracture of arm	0.002	0.998	0.000
Q37.8 Unspecified cleft palate with bilateral cleft lip	0.002	0.998	0.000
Q37.5 Cleft hard and soft palate with unilateral cleft lip	0.002	0.998	0.000
Q37.4 Cleft hard and soft palate with bilateral cleft lip	0.002	0.998	0.000
Q37.3 Cleft soft palate with unilateral cleft lip	0.002	0.998	0.000
Q37.2 Cleft soft palate with bilateral cleft lip	0.002	0.998	0.000
Q37.1 Cleft hard palate with unilateral cleft lip	0.002	0.998	0.000
Q37.0 Cleft hard palate with bilateral cleft lip	0.002	0.998	0.000
H75 Other disorders of middle ear and mastoid in diseases classified elsewhere	0.000	0.998	0.002
H68 Eustachian salpingitis and obstruction	0.000	0.998	0.002
H67 Otitis media in diseases classified elsewhere	0.000	0.998	0.002

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations