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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs1383264
log Bayes Factor = 264.795
Chromosome 6   position 32,739,967  (GRCh37) Explore rs1383264 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E10.9 Without complications
1.000 0.000 0.000
E10.3 With ophthalmic complications
1.000 0.000 0.000
E10.1 With ketoacidosis
1.000 0.000 0.000
E16.2 Hypoglycaemia, unspecified
1.000 0.000 0.000
K90.0 Coeliac disease
1.000 0.000 0.000
L40.9 Psoriasis, unspecified
0.000 0.000 1.000
L40.5 Arthropathic psoriasis
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
1.000 0.000 0.000
G35 Multiple sclerosis
1.000 0.000 0.000
E10-E14 Diabetes mellitus
1.000 0.000 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
1.000 0.000 0.000
E05.0 Thyrotoxicosis with diffuse goitre
1.000 0.000 0.000
L40 Psoriasis
0.000 0.000 1.000
E14 Unspecified diabetes mellitus
1.000 0.000 0.000
E05 Thyrotoxicosis [hyperthyroidism]
1.000 0.000 0.000
E16 Other disorders of pancreatic internal secretion
1.000 0.000 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
1.000 0.000 0.000
G35-G37 Demyelinating diseases of the central nervous system
1.000 0.000 0.000
H36.0 Diabetic retinopathy
1.000 0.000 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
1.000 0.000 0.000
# Top node
0.999 0.001 0.000
Chapter VI Diseases of the nervous system
0.999 0.001 0.000
E00-E07 Disorders of thyroid gland
0.999 0.001 0.000
D50-D53 Nutritional anaemias
0.997 0.003 0.000
E10.4 With neurological complications
0.997 0.003 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.996 0.004 0.000
E14.9 Without complications
0.996 0.004 0.000
H36 Retinal disorders in diseases classified elsewhere
0.996 0.004 0.000
D51 Vitamin B12 deficiency anaemia
0.995 0.005 0.000
H30-H36 Disorders of choroid and retina
0.993 0.007 0.000
Chapter VII Diseases of the eye and adnexa
0.993 0.007 0.000
M07.3 Other psoriatic arthropathies
0.000 0.008 0.992
E10.2 With renal complications
0.991 0.009 0.000
M05-M14 Inflammatory polyarthropathies
0.001 0.009 0.991
E05.9 Thyrotoxicosis, unspecified
0.991 0.009 0.000
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.009 0.991
M07 Psoriatic and enteropathic arthropathies
0.000 0.009 0.991
M06 Other rheumatoid arthritis
0.000 0.009 0.991
M06.9 Rheumatoid arthritis, unspecified
0.000 0.010 0.990
D80-D89 Certain disorders involving the immune mechanism
0.989 0.011 0.000
E14.3 With ophthalmic complications
0.988 0.012 0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.986 0.014 0.000
E50-E64 Other nutritional deficiencies
0.985 0.015 0.000
D51.0 Vitamin B12 deficiency anaemia due to intrinsic factor deficiency
0.985 0.015 0.000
M07.39 Other psoriatic arthropathies (Site unspecified)
0.000 0.016 0.984
G04 Encephalitis, myelitis and encephalomyelitis
0.981 0.019 0.000
M05 Seropositive rheumatoid arthritis
0.000 0.019 0.980
K90 Intestinal malabsorption
0.975 0.025 0.000
D86 Sarcoidosis
0.975 0.025 0.000
M05.9 Seropositive rheumatoid arthritis, unspecified
0.000 0.027 0.973
D86.9 Sarcoidosis, unspecified
0.969 0.031 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.969 0.031 0.000
G04.9 Encephalitis, myelitis and encephalomyelitis, unspecified
0.965 0.035 0.000
C44.7 Skin of lower limb, including hip
0.000 0.035 0.965
K90.9 Intestinal malabsorption, unspecified
0.949 0.051 0.000
E40-E46 Malnutrition
0.948 0.052 0.000
M05.99 Seropositive rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.054 0.946
M07.30 Other psoriatic arthropathies (Multiple sites)
0.000 0.058 0.942
D69 Purpura and other haemorrhagic conditions
0.938 0.062 0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.938 0.062 0.000
E55 Vitamin D deficiency
0.936 0.064 0.000
D51.9 Vitamin B12 deficiency anaemia, unspecified
0.929 0.071 0.000
G37 Other demyelinating diseases of central nervous system
0.929 0.071 0.000
H46-H48 Disorders of optic nerve and visual pathways
0.925 0.075 0.000
H31 Other disorders of choroid
0.917 0.083 0.000
G00 Bacterial meningitis, not elsewhere classified
0.912 0.088 0.000
E46 Unspecified protein-energy malnutrition
0.910 0.090 0.000
E10.8 With unspecified complications
0.909 0.091 0.000
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.905 0.095 0.000
Q38-Q45 Other congenital malformations of the digestive system
0.904 0.096 0.000
E55.9 Vitamin D deficiency, unspecified
0.901 0.099 0.000
E14.8 With unspecified complications
0.893 0.107 0.000
M35.0 Sicca syndrome [Sjogren]
0.891 0.109 0.000
Q44 Congenital malformations of gallbladder, bile ducts and liver
0.885 0.115 0.000
G08 Intracranial and intraspinal phlebitis and thrombophlebitis
0.881 0.119 0.000
C44 Other malignant neoplasms of skin
0.000 0.120 0.880
M35 Other systemic involvement of connective tissue
0.880 0.120 0.000
D80 Immunodeficiency with predominantly antibody defects
0.878 0.122 0.000
E53 Deficiency of other B group vitamins
0.878 0.122 0.000
Q44.6 Cystic disease of liver
0.865 0.135 0.000
C44.3 Skin of other and unspecified parts of face
0.000 0.137 0.863
D67 Hereditary factor IX deficiency
0.862 0.138 0.000
H47 Other disorders of optic [2nd] nerve and visual pathways
0.856 0.144 0.000
D69.3 Idiopathic thrombocytopenic purpura
0.856 0.144 0.000
H25-H28 Disorders of lens
0.855 0.145 0.000
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.147 0.853
M07.34 Other psoriatic arthropathies (Hand)
0.000 0.150 0.850
E14.2 Withrenal complications
0.850 0.150 0.000
M05.90 Seropositive rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.155 0.845
D65 Disseminated intravascular coagulation [defibrination syndrome]
0.844 0.156 0.000
M07.36 Other psoriatic arthropathies (Lower leg)
0.000 0.163 0.837
M20-M25 Other joint disorders
0.830 0.170 0.000
L40.1 Generalised pustular psoriasis
0.000 0.174 0.826
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.824 0.176 0.000
H26 Other cataract
0.819 0.181 0.000
H31.0 Chorioretinal scars
0.817 0.182 0.000
M06.3 Rheumatoid nodule
0.000 0.184 0.816
H47.3 Other disorders of optic disk
0.815 0.185 0.000
G05 Encephalitis, myelitis and encephalomyelitis in diseases classified elsewhere
0.815 0.185 0.000
E10.6 With other specified complications
0.814 0.186 0.000
E10.0 With coma
0.813 0.187 0.000
Q74 Other congenital malformations of limb(s)
0.813 0.187 0.000
G36 Other acute disseminated demyelination
0.810 0.190 0.000
M07.37 Other psoriatic arthropathies (Ankle and foot)
0.000 0.192 0.808
G00.9 Bacterial meningitis, unspecified
0.807 0.193 0.000
E10.5 With peripheral circulatory complications
0.806 0.194 0.000
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.196 0.804
L40.8 Other psoriasis
0.000 0.196 0.804
D53 Other nutritional anaemias
0.803 0.197 0.000
E10.7 With multiple complications
0.802 0.198 0.000
M24 Other specific joint derangements
0.800 0.200 0.000
E16.0 Drug-induced hypoglycaemia without coma
0.796 0.204 0.000
H31.8 Other specified disorders of choroid
0.794 0.206 0.000
E16.1 Other hypoglycaemia
0.793 0.207 0.000
E54 Ascorbic acid deficiency
0.792 0.208 0.000
G37.9 Demyelinating disease of central nervous system, unspecified
0.791 0.209 0.000
M05.94 Seropositive rheumatoid arthritis, unspecified (Hand)
0.000 0.215 0.785
H26.4 After-cataract
0.782 0.218 0.000
D52 Folate deficiency anaemia
0.782 0.218 0.000
Q66 Congenital deformities of feet
0.782 0.218 0.000
G37.8 Other specified demyelinating diseases of central nervous system
0.781 0.219 0.000
E14.6 With other specified complications
0.779 0.221 0.000
D69.8 Other specified haemorrhagic conditions
0.778 0.222 0.000
M35.1 Other overlap syndromes
0.776 0.224 0.000
Q79 Congenital malformations of musculoskeletal system, not elsewhere classified
0.776 0.224 0.000
M05.92 Seropositive rheumatoid arthritis, unspecified (Upper arm)
0.000 0.225 0.775
D51.8 Other vitamin B12 deficiency anaemias
0.773 0.227 0.000
E53.8 Deficiency of other specified B group vitamins
0.773 0.227 0.000
E58 Dietary calcium deficiency
0.772 0.228 0.000
H26.2 Complicated cataract
0.772 0.228 0.000
E63 Other nutritional deficiencies
0.770 0.230 0.000
D69.5 Secondary thrombocytopenia
0.770 0.230 0.000
G01 Meningitis in bacterial diseases classified elsewhere
0.767 0.233 0.000
Q30-Q34 Congenital malformations of the respiratory system
0.766 0.234 0.000
M35.3 Polymyalgia rheumatica
0.765 0.235 0.000
M06.0 Seronegative rheumatoid arthritis
0.000 0.237 0.763
D82 Immunodeficiency associated with other major defects
0.762 0.238 0.000
M86-M90 Other osteopathies
0.762 0.238 0.000
G04.0 Acute disseminated encephalitis
0.761 0.239 0.000
Chapter XII Diseases of the skin and subcutaneous tissue
0.686 0.240 0.074
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.759 0.241 0.000
C44.5 Skin of trunk
0.000 0.241 0.759
G04.8 Other encephalitis, myelitis and encephalomyelitis
0.758 0.242 0.000
M24.1 Other articular cartilage disorders
0.754 0.246 0.000
C44.4 Skin of scalp and neck
0.000 0.248 0.752
M07.35 Other psoriatic arthropathies (Pelvic region and thigh)
0.000 0.250 0.750
Q20-Q28 Congenital malformations of the circulatory system
0.750 0.250 0.000
M06.4 Inflammatory polyarthropathy
0.000 0.251 0.749
M05.95 Seropositive rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.253 0.747
E14.0 With coma
0.746 0.253 0.000
H48 Disorders of optic [2nd] nerve and visual pathways in diseases classified elsewhere
0.746 0.254 0.000
H30 Chorioretinal inflammation
0.745 0.255 0.000
Q35-Q37 Cleft lip and cleft palate
0.745 0.255 0.000
D69.2 Other nonthrombocytopenic purpura
0.745 0.255 0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.745 0.255 0.000
Q78 Other osteochondrodysplasias
0.742 0.258 0.000
L40.4 Guttate psoriasis
0.000 0.259 0.740
M60-M63 Disorders of muscles
0.736 0.264 0.000
Q90-Q99 Chromosomal abnormalities, not elsewhere classified
0.734 0.265 0.000
E14.5 With peripheral circulatory complications
0.733 0.267 0.000
E07 Other disorders of thyroid
0.732 0.268 0.000
Chapter XXII Codes for special purposes
0.732 0.268 0.000
Q65 Congenital deformities of hip
0.732 0.268 0.000
D68 Other coagulation defects
0.732 0.268 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.731 0.269 0.000
E20-E35 Disorders of other endocrine glands
0.729 0.271 0.000
M11 Other crystal arthropathies
0.000 0.271 0.729
E27.1 Primary adrenocortical insufficiency
0.729 0.271 0.000
M21 Other acquired deformities of limbs
0.729 0.271 0.000
D80.6 Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinaemia
0.728 0.272 0.000
Q67 Congenital musculoskeletal deformities of head, face, spine and chest
0.725 0.275 0.000
M05.91 Seropositive rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.275 0.725
M24.0 Loose body in joint
0.725 0.275 0.000
M05.1 Rheumatoid lung disease
0.000 0.276 0.723
E27 Other disorders of adrenal gland
0.723 0.277 0.000
G00.1 Pneumococcal meningitis
0.723 0.277 0.000
D86.8 Sarcoidosis of other and combined sites
0.720 0.280 0.000
Q00-Q07 Congenital malformations of the nervous system
0.719 0.281 0.000
M24.16 Other articular cartilage disorders (Lower leg)
0.718 0.282 0.000
E12 Malnutrition-related diabetes mellitus
0.717 0.283 0.000
L40.2 Acrodermatitis continua
0.000 0.283 0.717
E14.7 With multiple complications
0.717 0.283 0.000
E05.5 Thyroid crisis or storm
0.717 0.283 0.000
E05.4 Thyrotoxicosis factitia
0.717 0.283 0.000
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.717 0.283 0.000
E16.9 Disorder of pancreatic internal secretion, unspecified
0.717 0.283 0.000
E16.8 Other specified disorders of pancreatic internal secretion
0.717 0.283 0.000
E16.4 Abnormal secretion of gastrin
0.717 0.283 0.000
E16.3 Increased secretion of glucagon
0.717 0.283 0.000
E15 Nondiabetic hypoglycaemic coma
0.717 0.283 0.000
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.716 0.284 0.000
E00 Congenital iodine-deficiency syndrome
0.716 0.284 0.000
H15-H22 Disorders of sclera, cornea, iris and ciliary body
0.716 0.284 0.000
G09 Sequelae of inflammatory diseases of central nervous system
0.715 0.285 0.000
L40.0 Psoriasis vulgaris
0.000 0.286 0.714
G07 Intracranial and intraspinal abscess and granuloma in diseases classified elsewhere
0.714 0.286 0.000
H36.8 Other retinal disorders in diseases classified elsewhere
0.714 0.286 0.000
M05.8 Other seropositive rheumatoid arthritis
0.000 0.286 0.713
E51 Thiamine deficiency
0.713 0.286 0.000
L10-L14 Bullous disorders
0.661 0.287 0.052
D51.2 Transcobalamin II deficiency
0.713 0.287 0.000
D51.1 Vitamin B12 deficiency anaemia due to selective vitamin B12 malabsorption with proteinuria
0.713 0.287 0.000
H32 Chorioretinal disorders in diseases classified elsewhere
0.712 0.288 0.000
H00-H06 Disorders of eyelid, lacrimal system and orbit
0.712 0.288 0.000
M07.33 Other psoriatic arthropathies (Forearm)
0.000 0.289 0.711
M07.32 Other psoriatic arthropathies (Upper arm)
0.000 0.289 0.711
M07.31 Other psoriatic arthropathies (Shoulder region)
0.000 0.289 0.711
G00.2 Streptococcal meningitis
0.711 0.289 0.000
M09 Juvenile arthritis in diseases classified elsewhere
0.001 0.289 0.710
M07.5 Arthropathy in ulcerative colitis
0.000 0.289 0.710
M07.4 Arthropathy in Crohn's disease [regional enteritis]
0.000 0.289 0.710
M07.2 Psoriatic spondylitis
0.000 0.289 0.710
M07.1 Arthritis mutilans
0.000 0.289 0.710
M07.0 Distal interphalangeal psoriatic arthropathy
0.000 0.289 0.710
M33 Dermatopolymyositis
0.711 0.289 0.000
Q74.0 Other congenital malformations of upper limb(s), including shoulder girdle
0.710 0.290 0.000
M06.2 Rheumatoid bursitis
0.000 0.290 0.710
M06.1 Adult-onset Still's disease
0.000 0.290 0.710
D81 Combined immunodeficiencies
0.709 0.291 0.000
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.293 0.707
E64 Sequelae of malnutrition and other nutritional deficiencies
0.707 0.293 0.000
E50 Vitamin A deficiency
0.707 0.293 0.000
E60 Dietary zinc deficiency
0.707 0.293 0.000
E59 Dietary selenium deficiency
0.707 0.293 0.000
E52 Niacin deficiency [pellagra]
0.707 0.293 0.000
J45.9 Asthma, unspecified
0.706 0.294 0.000
Q10-Q18 Congenital malformations of eye, ear, face and neck
0.705 0.295 0.000
M06.8 Other specified rheumatoid arthritis
0.000 0.296 0.704
G04.2 Bacterial meningoencephalitis and meningomyelitis, not elsewhere classified
0.704 0.296 0.000
G04.1 Tropical spastic paraplegia
0.704 0.296 0.000
D66 Hereditary factor VIII deficiency
0.704 0.296 0.000
M05.3 Rheumatoid arthritis with involvement of other organs and systems
0.000 0.297 0.703
M05.0 Felty's syndrome
0.000 0.297 0.703
M32 Systemic lupus erythematosus
0.702 0.298 0.000
H06 Disorders of lachrymal system and orbit in diseases classified elsewhere
0.701 0.299 0.000
K90.3 Pancreatic steatorrhoea
0.699 0.301 0.000
K90.2 Blind loop syndrome, not elsewhere classified
0.699 0.301 0.000
K90.1 Tropical sprue
0.699 0.301 0.000
R31 Unspecified haematuria
0.000 0.301 0.699
G70-G73 Diseases of myoneural junction and muscle
0.699 0.301 0.000
M35.7 Hypermobility syndrome
0.698 0.302 0.000
M24.11 Other articular cartilage disorders (Shoulder region)
0.698 0.302 0.000
M05.98 Seropositive rheumatoid arthritis, unspecified (Other)
0.000 0.302 0.698
M05.93 Seropositive rheumatoid arthritis, unspecified (Forearm)
0.000 0.302 0.698
D80.2 Selective deficiency of immunoglobulin A [IgA]
0.698 0.302 0.000
E53.9 Vitamin B deficiency, unspecified
0.698 0.302 0.000
H26.3 Drug-induced cataract
0.697 0.303 0.000
M05.96 Seropositive rheumatoid arthritis, unspecified (Lower leg)
0.000 0.303 0.697
D51.3 Other dietary vitamin B12 deficiency anaemia
0.696 0.304 0.000
M08 Juvenile arthritis
0.001 0.304 0.696
M89 Other disorders of bone
0.696 0.304 0.000
H06.2 Dysthyroid exophthalmos
0.694 0.306 0.000
G02 Meningitis in other infectious and parasitic diseases classified elsewhere
0.693 0.307 0.000
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.000 0.307 0.693
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.693 0.307 0.000
L40-L45 Papulosquamous disorders
0.120 0.309 0.570
C44.2 Skin of ear and external auricular canal
0.000 0.310 0.690
Q79.6 Ehlers-Danlos syndrome
0.690 0.310 0.000
K90.8 Other intestinal malabsorption
0.690 0.310 0.000
M07.6 Other enteropathic arthropathies
0.000 0.311 0.689
D80.3 Selective deficiency of immunoglobulin G [IgG] subclasses
0.688 0.311 0.000
H31.9 Disorder of choroid, unspecified
0.688 0.312 0.000
Q44.4 Choledochal cyst
0.687 0.313 0.000
G05.1 Encephalitis, myelitis and encephalomyelitis in viral diseases classified elsewhere
0.684 0.316 0.000
E05.8 Other thyrotoxicosis
0.683 0.317 0.000
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes
0.683 0.317 0.000
D69.9 Haemorrhagic condition, unspecified
0.682 0.318 0.000
D80.1 Nonfamilial hypogammaglobulinaemia
0.681 0.319 0.000
Q66.8 Other congenital deformities of feet
0.681 0.319 0.000
Q68 Other congenital musculoskeletal deformities
0.680 0.320 0.000
E44 Protein-energy malnutrition of moderate and mild degree
0.679 0.320 0.000
E45 Retarded development following protein-energy malnutrition
0.679 0.320 0.000
E43 Unspecified severe protein-energy malnutrition
0.679 0.320 0.000
E42 Marasmic kwashiorkor
0.679 0.320 0.000
E41 Nutritional marasmus
0.679 0.320 0.000
E40 Kwashiorkor
0.679 0.320 0.000
M05.97 Seropositive rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.321 0.679
L13 Other bullous disorders
0.655 0.321 0.024
M89.9 Disorder of bone, unspecified
0.678 0.322 0.000
Q77 Osteochondrodysplasia with defects of growth of tubular bones and spine
0.677 0.322 0.000
L40.3 Pustulosis palmaris et plantaris
0.000 0.324 0.675
D89 Other disorders involving the immune mechanism, not elsewhere classified
0.675 0.325 0.000
H47.2 Optic atrophy
0.675 0.325 0.000
D69.0 Allergic purpura
0.674 0.325 0.000
L20-L30 Dermatitis and eczema
0.673 0.326 0.001
G36.0 Neuromyelitis optica [Devic]
0.673 0.326 0.000
E56 Other vitamin deficiencies
0.673 0.327 0.000
Q75 Other congenital malformations of skull and face bones
0.672 0.328 0.000
Q73 Reduction defects of unspecified limb
0.672 0.328 0.000
Q72 Reduction defects of lower limb
0.672 0.328 0.000
Q71 Reduction defects of upper limb
0.672 0.328 0.000
Q70 Syndactyly
0.672 0.328 0.000
Q69 Polydactyly
0.672 0.328 0.000
D50 Iron deficiency anaemia
0.672 0.328 0.000
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.672 0.328 0.000
E55.0 Rickets, active
0.671 0.329 0.000
M35.8 Other specified systemic involvement of connective tissue
0.670 0.329 0.000
M24.02 Loose body in joint (Upper arm)
0.670 0.330 0.000
M06.32 Rheumatoid nodule (Upper arm)
0.000 0.330 0.670
Q23 Congenital malformations of aortic and mitral valves
0.667 0.333 0.000
H26.1 Traumatic cataract
0.667 0.333 0.000
M06.98 Rheumatoid arthritis, unspecified (Other)
0.000 0.333 0.667
Q44.5 Other congenital malformations of bile ducts
0.667 0.333 0.000
G37.5 Concentric sclerosis [Balo]
0.666 0.334 0.000
G37.4 Subacute necrotising myelitis
0.666 0.334 0.000
G37.2 Central pontine myelinolysis
0.666 0.334 0.000
G37.1 Central demyelination of corpus callosum
0.666 0.334 0.000
G37.0 Diffuse sclerosis
0.666 0.334 0.000
D83 Common variable immunodeficiency
0.666 0.334 0.000
D80.9 Immunodeficiency with predominantly antibody defects, unspecified
0.665 0.335 0.000
M60 Myositis
0.664 0.336 0.000
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.000 0.337 0.663
M05.2 Rheumatoid vasculitis
0.000 0.337 0.663
Q22 Congenital malformations of pulmonary and tricuspid valves
0.662 0.338 0.000
L27 Dermatitis due to substances taken internally
0.658 0.342 0.000
H31.4 Choroidal detachment
0.658 0.342 0.000
H31.2 Hereditary choroidal dystrophy
0.658 0.342 0.000
D68.3 Haemorrhagic disorder due to circulating anticoagulants
0.655 0.345 0.000
L13.0 Dermatitis herpetiformis
0.651 0.345 0.004
M21.1 Varus deformity, not elsewhere classified
0.655 0.345 0.000
Q45 Other congenital malformations of digestive system
0.655 0.345 0.000
G00.8 Other bacterial meningitis
0.654 0.346 0.000
G00.3 Staphylococcal meningitis
0.654 0.346 0.000
G00.0 Haemophilus meningitis
0.654 0.346 0.000
M07.38 Other psoriatic arthropathies (Other)
0.000 0.346 0.654
U82-U85 Resistance to antimicrobial and antineoplastic drugs
0.654 0.346 0.000
D86.1 Sarcoidosis of lymph nodes
0.654 0.346 0.000
H28 Cataract and other disorders of lens in diseases classified elsewhere
0.653 0.347 0.000
D69.1 Qualitative platelet defects
0.651 0.349 0.000
H46 Optic neuritis
0.651 0.349 0.000
Q66.0 Talipes equinovarus
0.650 0.350 0.000
D84 Other immunodeficiencies
0.650 0.350 0.000
H10-H13 Disorders of conjunctiva
0.649 0.351 0.000
Q42 Congenital absence, atresia and stenosis of large intestine
0.648 0.351 0.000
Q41 Congenital absence, atresia and stenosis of small intestine
0.648 0.351 0.000
M21.0 Valgus deformity, not elsewhere classified
0.645 0.355 0.000
E61 Deficiency of other nutrient elements
0.644 0.356 0.000
Q74.2 Other congenital malformations of lower limb(s), including pelvic girdle
0.639 0.361 0.000
M06.37 Rheumatoid nodule (Ankle and foot)
0.000 0.364 0.636
Q44.7 Other congenital malformations of liver
0.634 0.365 0.000
Q44.3 Congenital stenosis and stricture of bile ducts
0.634 0.365 0.000
Q44.2 Atresia of bile ducts
0.634 0.365 0.000
Q44.1 Other congenital malformations of gallbladder
0.634 0.365 0.000
Q44.0 Agenesis, aplasia and hypoplasia of gallbladder
0.634 0.365 0.000
G03 Meningitis due to other and unspecified causes
0.632 0.367 0.000
Q76 Congenital malformations of spine and bony thorax
0.632 0.368 0.000
D69.6 Thrombocytopenia, unspecified
0.631 0.369 0.000
C44.8 Overlapping lesion of skin
0.000 0.369 0.631
M35.9 Systemic involvement of connective tissue, unspecified
0.631 0.369 0.000
M35.6 Relapsing panniculitis [Weber-Christian]
0.631 0.369 0.000
M35.5 Multifocal fibrosclerosis
0.631 0.369 0.000
M35.4 Diffuse (eosinophilic) fasciitis
0.631 0.369 0.000
D80.8 Other immunodeficiencies with predominantly antibody defects
0.630 0.370 0.000
D80.7 Transient hypogammaglobulinaemia of infancy
0.630 0.370 0.000
D80.5 Immunodeficiency with increased immunoglobulin M [IgM]
0.630 0.370 0.000
D80.0 Hereditary hypogammaglobulinaemia
0.630 0.370 0.000
E53.1 Pyridoxine deficiency
0.630 0.370 0.000
E53.0 Riboflavin deficiency
0.630 0.370 0.000
D86.0 Sarcoidosis of lung
0.628 0.372 0.000
D52.9 Folate deficiency anaemia, unspecified
0.627 0.373 0.000
D53.1 Other megaloblastic anaemias, not elsewhere classified
0.627 0.373 0.000
L27.1 Localised skin eruption due to drugs and medicaments
0.626 0.374 0.000
H31.1 Choroidal degeneration
0.625 0.375 0.000
D53.9 Nutritional anaemia, unspecified
0.624 0.376 0.000
M24.07 Loose body in joint (Ankle and foot)
0.623 0.377 0.000
Q31 Congenital malformations of larynx
0.621 0.379 0.000
M86 Osteomyelitis
0.619 0.381 0.000
H48.1 Retrobulbar neuritis in diseases classified elsewhere
0.619 0.381 0.000
H27 Other disorders of lens
0.618 0.382 0.000
M34 Systemic sclerosis
0.617 0.382 0.000
Q35 Cleft palate
0.616 0.383 0.000
E63.9 Nutritional deficiency, unspecified
0.616 0.384 0.000
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system
0.616 0.384 0.000
Q23.1 Congenital insufficiency of aortic valve
0.616 0.384 0.000
E02 Subclinical iodine-deficiency hypothyroidism
0.615 0.385 0.000
H31.3 Choroidal haemorrhage and rupture
0.615 0.385 0.000
H47.7 Disorder of visual pathways, unspecified
0.614 0.386 0.000
H47.6 Disorders of visual cortex
0.614 0.386 0.000
H47.5 Disorders of other visual pathways
0.614 0.386 0.000
H47.4 Disorders of optic chiasm
0.614 0.386 0.000
D69.4 Other primary thrombocytopenia
0.613 0.386 0.000
M33.1 Other dermatomyositis
0.613 0.386 0.000
M21.06 Valgus deformity, not elsewhere classified (Lower leg)
0.612 0.388 0.000
H19 Disorders of sclera and cornea in diseases classified elsewhere
0.611 0.389 0.000
H18 Other disorders of cornea
0.611 0.389 0.000
M00-M03 Infectious arthropathies
0.610 0.390 0.000
Q38 Other congenital malformations of tongue, mouth and pharynx
0.610 0.390 0.000
E14.1 With ketoacidosis
0.610 0.390 0.000
E34 Other endocrine disorders
0.609 0.391 0.000
Q27 Other congenital malformations of peripheral vascular system
0.608 0.392 0.000
M89.98 Disorder of bone, unspecified (Other)
0.608 0.392 0.000
M89.96 Disorder of bone, unspecified (Lower leg)
0.607 0.393 0.000
D68.8 Other specified coagulation defects
0.606 0.394 0.000
U88 Agent resistant to multiple antibiotics
0.605 0.395 0.000
M24.2 Disorder of ligament
0.604 0.396 0.000
M24.3 Pathological dislocation and subluxation of joint, not elsewhere classified
0.604 0.396 0.000
M32.1 Systemic lupus erythematosus with organ or system involvement
0.603 0.397 0.000
Q67.6 Pectus excavatum
0.602 0.397 0.000
Q78.0 Osteogenesis imperfecta
0.601 0.399 0.000
D86.3 Sarcoidosis of skin
0.600 0.400 0.000
Q40 Other congenital malformations of upper alimentary tract
0.600 0.400 0.000
D82.1 Di George's syndrome
0.599 0.401 0.000
M60.9 Myositis, unspecified
0.597 0.403 0.000
Q66.3 Other congenital varus deformities of feet
0.596 0.404 0.000
Q66.7 Pes cavus
0.594 0.406 0.000
Q39 Congenital malformations of oesophagus
0.594 0.406 0.000
Q60-Q64 Congenital malformations of the urinary system
0.593 0.407 0.000
D89.9 Disorder involving the immune mechanism, unspecified
0.593 0.407 0.000
L27.0 Generalised skin eruption due to drugs and medicaments
0.593 0.407 0.000
M90 Osteopathies in diseases classified elsewhere
0.590 0.410 0.000
E27.2 Addisonian crisis
0.590 0.410 0.000
Q65.8 Other congenital deformities of hip
0.589 0.411 0.000
Q22.5 Ebstein's anomaly
0.588 0.412 0.000
M06.00 Seronegative rheumatoid arthritis (Multiple sites)
0.000 0.413 0.587
M06.39 Rheumatoid nodule (Site unspecified)
0.000 0.415 0.585
M06.38 Rheumatoid nodule (Other)
0.000 0.415 0.585
M06.36 Rheumatoid nodule (Lower leg)
0.000 0.415 0.585
M06.35 Rheumatoid nodule (Pelvic region and thigh)
0.000 0.415 0.585
M06.33 Rheumatoid nodule (Forearm)
0.000 0.415 0.585
M06.31 Rheumatoid nodule (Shoulder region)
0.000 0.415 0.585
G05.8 Encephalitis, myelitis and encephalomyelitis in other diseases classified elsewhere
0.584 0.416 0.000
G05.2 Encephalitis, myelitis and encephalomyelitis in other infectious and parasitic diseases classified elsewhere
0.584 0.416 0.000
G05.0 Encephalitis, myelitis and encephalomyelitis in bacterial diseases classified elsewhere
0.584 0.416 0.000
M21.6 Other acquired deformities of ankle and foot
0.584 0.416 0.000
Q74.9 Unspecified congenital malformation of limb(s)
0.583 0.417 0.000
Q74.8 Other specified congenital malformations of limb(s)
0.583 0.417 0.000
Q74.3 Arthrogryposis multiplex congenita
0.583 0.417 0.000
G11 Hereditary ataxia
0.582 0.418 0.000
D50.9 Iron deficiency anaemia, unspecified
0.582 0.418 0.000
G14 Postpolio syndrome
0.581 0.419 0.000
G36.9 Acute disseminated demyelination, unspecified
0.580 0.419 0.000
G36.8 Other specified acute disseminated demyelination
0.580 0.419 0.000
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.580 0.419 0.000
Q99 Other chromosome abnormalities, not elsewhere classified
0.580 0.419 0.000
M14 Arthropathies in other diseases classified elsewhere
0.001 0.420 0.579
M06.46 Inflammatory polyarthropathy (Lower leg)
0.000 0.420 0.579
M24.8 Other specific joint derangements, not elsewhere classified
0.579 0.421 0.000
M06.07 Seronegative rheumatoid arthritis (Ankle and foot)
0.000 0.421 0.579
Q04 Other congenital malformations of brain
0.578 0.422 0.000
H10 Conjunctivitis
0.578 0.422 0.000
E22 Hyperfunction of pituitary gland
0.577 0.423 0.000
G63 Polyneuropathy in diseases classified elsewhere
0.577 0.423 0.000
D53.8 Other specified nutritional anaemias
0.576 0.424 0.000
D53.2 Scorbutic anaemia
0.576 0.424 0.000
D53.0 Protein deficiency anaemia
0.576 0.424 0.000
M06.34 Rheumatoid nodule (Hand)
0.000 0.424 0.576
M24.9 Joint derangement, unspecified
0.574 0.426 0.000
H04 Disorders of lachrymal system
0.573 0.427 0.000
M06.30 Rheumatoid nodule (Multiple sites)
0.000 0.427 0.573
M21.16 Varus deformity, not elsewhere classified (Lower leg)
0.573 0.427 0.000
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.000 0.428 0.572
L26 Exfoliative dermatitis
0.571 0.428 0.001
M89.95 Disorder of bone, unspecified (Pelvic region and thigh)
0.570 0.429 0.000
M11.9 Crystal arthropathy, unspecified
0.000 0.430 0.569
M33.9 Dermatopolymyositis, unspecified
0.569 0.431 0.000
H47.1 Papilloedema, unspecified
0.569 0.431 0.000
Q17 Other congenital malformations of ear
0.567 0.432 0.000
H30.9 Chorioretinal inflammation, unspecified
0.567 0.433 0.000
D68.2 Hereditary deficiency of other clotting factors
0.567 0.433 0.000
Q98 Other sex chromosome abnormalities, male phenotype, not elsewhere classified
0.564 0.436 0.000
D52.8 Other folate deficiency anaemias
0.560 0.439 0.000
D52.1 Drug-induced folate deficiency anaemia
0.560 0.439 0.000
D52.0 Dietary folate deficiency anaemia
0.560 0.439 0.000
Q66.5 Congenital pes planus
0.560 0.439 0.000
Q66.4 Talipes calcaneovalgus
0.560 0.439 0.000
Q66.1 Talipes calcaneovarus
0.560 0.439 0.000
D68.6 Other Thrombophilia
0.560 0.440 0.000
M89.5 Osteolysis
0.559 0.441 0.000
M24.15 Other articular cartilage disorders (Pelvic region and thigh)
0.558 0.442 0.000
M06.09 Seronegative rheumatoid arthritis (Site unspecified)
0.000 0.443 0.557
E31 Polyglandular dysfunction
0.556 0.443 0.000
Q79.9 Congenital malformation of musculoskeletal system, unspecified
0.556 0.444 0.000
Q79.5 Other congenital malformations of abdominal wall
0.556 0.444 0.000
Q79.4 Prune belly syndrome
0.556 0.444 0.000
Q79.3 Gastroschisis
0.556 0.444 0.000
Q79.2 Exomphalos
0.556 0.444 0.000
Q79.1 Other congenital malformations of diaphragm
0.556 0.444 0.000
Q79.0 Congenital diaphragmatic hernia
0.556 0.444 0.000
M12 Other specific arthropathies
0.001 0.444 0.555
M21.5 Acquired clawhand, clubhand, clawfoot and clubfoot
0.556 0.444 0.000
M62 Other disorders of muscle
0.556 0.444 0.000
M89.97 Disorder of bone, unspecified (Ankle and foot)
0.555 0.445 0.000
G06 Intracranial and intraspinal abscess and granuloma
0.554 0.446 0.000
H33 Retinal detachments and breaks
0.554 0.446 0.000
H03 Disorders of eyelid in diseases classified elsewhere
0.554 0.446 0.000
E14.4 With neurological complications
0.552 0.447 0.000
E63.8 Other specified nutritional deficiencies
0.552 0.447 0.000
E63.1 Imbalance of constituents of food intake
0.552 0.447 0.000
E63.0 Essential fatty acid [EFA] deficiency
0.552 0.447 0.000
Q66.6 Other congenital valgus deformities of feet
0.552 0.448 0.000
Q65.1 Congenital dislocation of hip, bilateral
0.551 0.448 0.000
H04.1 Other disorders of lachrymal gland
0.552 0.448 0.000
M24.4 Recurrent dislocation and subluxation of joint
0.550 0.450 0.000
M06.05 Seronegative rheumatoid arthritis (Pelvic region and thigh)
0.000 0.450 0.549
Q34 Other congenital malformations of respiratory system
0.549 0.451 0.000
Q33 Congenital malformations of lung
0.549 0.451 0.000
Q32 Congenital malformations of trachea and bronchus
0.549 0.451 0.000
Q30 Congenital malformations of nose
0.549 0.451 0.000
M24.7 Protrusio acetabuli
0.549 0.451 0.000
G63.2 Diabetic polyneuropathy
0.549 0.451 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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