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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs1419640
log Bayes Factor = 51.8795
Chromosome 6   position 29,350,854  (GRCh37) Explore rs1419640 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E83.1 Disorders of iron metabolism
0.000 0.000 1.000
K90.0 Coeliac disease
1.000 0.000 0.000
E05.9 Thyrotoxicosis, unspecified
0.998 0.002 0.000
E16.2 Hypoglycaemia, unspecified
0.996 0.004 0.000
E05 Thyrotoxicosis [hyperthyroidism]
0.995 0.005 0.000
E16 Other disorders of pancreatic internal secretion
0.993 0.007 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.989 0.011 0.000
E10 Insulin-dependent diabetes mellitus
0.987 0.013 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.987 0.013 0.000
E10-E14 Diabetes mellitus
0.987 0.013 0.000
E00-E07 Disorders of thyroid gland
0.984 0.016 0.000
E10.3 With ophthalmic complications
0.966 0.034 0.000
E10.9 Without complications
0.964 0.036 0.000
E05.0 Thyrotoxicosis with diffuse goitre
0.942 0.058 0.000
E10.2 With renal complications
0.913 0.087 0.000
E10.4 With neurological complications
0.903 0.097 0.000
E13 Other specified diabetes mellitus
0.841 0.159 0.000
E05.8 Other thyrotoxicosis
0.828 0.172 0.000
E16.1 Other hypoglycaemia
0.805 0.195 0.000
E10.1 With ketoacidosis
0.794 0.206 0.000
E40-E46 Malnutrition
0.761 0.239 0.000
E13.9 Without complications
0.733 0.267 0.000
E16.0 Drug-induced hypoglycaemia without coma
0.731 0.269 0.000
E14 Unspecified diabetes mellitus
0.729 0.271 0.000
E05.5 Thyroid crisis or storm
0.713 0.287 0.000
E05.4 Thyrotoxicosis factitia
0.713 0.287 0.000
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.713 0.287 0.000
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.713 0.287 0.000
E16.9 Disorder of pancreatic internal secretion, unspecified
0.712 0.288 0.000
E16.8 Other specified disorders of pancreatic internal secretion
0.712 0.288 0.000
E16.4 Abnormal secretion of gastrin
0.712 0.288 0.000
E16.3 Increased secretion of glucagon
0.712 0.288 0.000
E15 Nondiabetic hypoglycaemic coma
0.709 0.291 0.000
E12 Malnutrition-related diabetes mellitus
0.707 0.293 0.000
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.706 0.294 0.000
E00 Congenital iodine-deficiency syndrome
0.706 0.294 0.000
E10.6 With other specified complications
0.666 0.334 0.000
E10.7 With multiple complications
0.653 0.346 0.000
E10.0 With coma
0.638 0.362 0.000
E13.3 With ophthalmic complications
0.610 0.390 0.000
E14.6 With other specified complications
0.604 0.396 0.000
E13.8 With unspecified complications
0.603 0.397 0.000
E13.7 With multiple complications
0.603 0.397 0.000
E13.6 With other specified complications
0.603 0.397 0.000
E13.5 With peripheral circulatory complications
0.603 0.397 0.000
E13.4 With neurological complications
0.603 0.397 0.000
E13.2 With renal complications
0.603 0.397 0.000
E13.1 With ketoacidosis
0.603 0.397 0.000
E13.0 With coma
0.603 0.397 0.000
E02 Subclinical iodine-deficiency hypothyroidism
0.600 0.400 0.000
E46 Unspecified protein-energy malnutrition
0.599 0.401 0.000
E14.3 With ophthalmic complications
0.588 0.412 0.000
E14.1 With ketoacidosis
0.588 0.412 0.000
E14.8 With unspecified complications
0.552 0.448 0.000
E44 Protein-energy malnutrition of moderate and mild degree
0.545 0.454 0.000
E45 Retarded development following protein-energy malnutrition
0.545 0.454 0.000
E43 Unspecified severe protein-energy malnutrition
0.545 0.454 0.000
E42 Marasmic kwashiorkor
0.545 0.454 0.000
E41 Nutritional marasmus
0.545 0.454 0.000
E40 Kwashiorkor
0.545 0.454 0.000
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.537 0.462 0.000
E07 Other disorders of thyroid
0.535 0.465 0.000
E14.2 Withrenal complications
0.530 0.470 0.000
E14.7 With multiple complications
0.523 0.477 0.000
E14.0 With coma
0.523 0.477 0.000
E10.5 With peripheral circulatory complications
0.508 0.492 0.000
E12.9 Without complications
0.507 0.493 0.000
E12.8 With unspecified complications
0.507 0.493 0.000
E12.7 With multiple complications
0.507 0.493 0.000
E12.6 With other specified complications
0.507 0.493 0.000
E12.5 With peripheral circulatory complications
0.507 0.493 0.000
E12.4 With neurological complications
0.507 0.493 0.000
E12.3 With ophthalmic complications
0.507 0.493 0.000
E12.2 With renal complications
0.507 0.493 0.000
E12.1 With ketoacidosis
0.507 0.493 0.000
E12.0 With coma
0.507 0.493 0.000
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.506 0.494 0.000
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.506 0.494 0.000
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.506 0.494 0.000
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.506 0.494 0.000
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.506 0.494 0.000
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.506 0.494 0.000
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.506 0.494 0.000
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.506 0.494 0.000
E03 Other hypothyroidism
0.492 0.508 0.000
E14.4 With neurological complications
0.491 0.509 0.000
E11 Non-insulin-dependent diabetes mellitus
0.489 0.511 0.000
E14.5 With peripheral circulatory complications
0.487 0.512 0.000
E10.8 With unspecified complications
0.466 0.534 0.001
E11.6 With other specified complications
0.463 0.537 0.000
E06 Thyroiditis
0.454 0.544 0.001
K90 Intestinal malabsorption
0.440 0.560 0.000
E11.1 With ketoacidosis
0.408 0.592 0.000
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.399 0.601 0.000
I83.9 Varicose veins of lower extremities without ulcer or inflammation
0.000 0.601 0.399
E44.1 Mild protein-energy malnutrition
0.391 0.609 0.000
E44.0 Moderate protein-energy malnutrition
0.391 0.609 0.000
E07.8 Other specified disorders of thyroid
0.384 0.616 0.000
E07.1 Dyshormogenetic goitre
0.384 0.616 0.000
E07.0 Hypersecretion of calcitonin
0.384 0.616 0.000
E11.7 With multiple complications
0.367 0.633 0.000
E03.0 Congenital hypothyroidism with diffuse goitre
0.355 0.645 0.000
E11.0 With coma
0.354 0.646 0.000
E03.5 Myxoedema coma
0.352 0.647 0.000
E03.4 Atrophy of thyroid (acquired)
0.352 0.647 0.000
E03.3 Postinfectious hypothyroidism
0.352 0.647 0.000
E03.8 Other specified hypothyroidism
0.347 0.653 0.000
E50-E64 Other nutritional deficiencies
0.345 0.655 0.000
E03.1 Congenital hypothyroidism without goitre
0.342 0.657 0.000
E06.1 Subacute thyroiditis
0.341 0.658 0.001
E11.2 With renal complications
0.339 0.661 0.000
E11.8 With unspecified complications
0.337 0.662 0.000
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.335 0.665 0.000
E06.9 Thyroiditis, unspecified
0.326 0.673 0.001
E65-E68 Obesity and other hyperalimentation
0.327 0.673 0.000
E06.4 Drug-induced thyroiditis
0.326 0.673 0.001
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.326 0.673 0.001
E06.0 Acute thyroiditis
0.326 0.673 0.001
K90.9 Intestinal malabsorption, unspecified
0.326 0.674 0.000
E06.5 Other chronic thyroiditis
0.316 0.683 0.001
K90.3 Pancreatic steatorrhoea
0.316 0.684 0.000
K90.2 Blind loop syndrome, not elsewhere classified
0.316 0.684 0.000
K90.1 Tropical sprue
0.316 0.684 0.000
K90.8 Other intestinal malabsorption
0.283 0.717 0.000
E11.3 With ophthalmic complications
0.276 0.724 0.000
E54 Ascorbic acid deficiency
0.259 0.741 0.000
E51 Thiamine deficiency
0.256 0.744 0.000
E83 Disorders of mineral metabolism
0.000 0.744 0.256
E64 Sequelae of malnutrition and other nutritional deficiencies
0.247 0.753 0.000
E63 Other nutritional deficiencies
0.247 0.753 0.000
E50 Vitamin A deficiency
0.247 0.753 0.000
E60 Dietary zinc deficiency
0.247 0.753 0.000
E59 Dietary selenium deficiency
0.247 0.753 0.000
E52 Niacin deficiency [pellagra]
0.247 0.753 0.000
E56 Other vitamin deficiencies
0.235 0.765 0.000
E67 Other hyperalimentation
0.234 0.765 0.000
E68 Sequelae of hyperalimentation
0.234 0.765 0.000
E58 Dietary calcium deficiency
0.230 0.770 0.000
E83.3 Disorders of phosphorus metabolism
0.000 0.778 0.222
E07.9 Disorder of thyroid, unspecified
0.212 0.788 0.000
E11.5 With peripheral circulatory complications
0.206 0.794 0.000
E83.9 Disorder of mineral metabolism, unspecified
0.000 0.802 0.198
E61 Deficiency of other nutrient elements
0.196 0.804 0.000
E51.2 Wernicke's encephalopathy
0.193 0.807 0.000
E55 Vitamin D deficiency
0.185 0.815 0.000
E65 Localised adiposity
0.184 0.815 0.000
E51.9 Thiamine deficiency, unspecified
0.184 0.816 0.000
E51.8 Other manifestations of thiamine deficiency
0.184 0.816 0.000
E51.1 Beriberi
0.184 0.816 0.000
E83.8 Other disorders of mineral metabolism
0.000 0.816 0.183
E83.2 Disorders of zinc metabolism
0.000 0.816 0.183
E83.0 Disorders of copper metabolism
0.000 0.816 0.183
E50.9 Vitamin A deficiency, unspecified
0.177 0.822 0.000
E50.8 Other manifestations of vitamin A deficiency
0.177 0.822 0.000
E50.7 Other ocular manifestations of vitamin A deficiency
0.177 0.822 0.000
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.177 0.822 0.000
E50.5 Vitamin A deficiency with night blindness
0.177 0.822 0.000
E50.4 Vitamin A deficiency with keratomalacia
0.177 0.822 0.000
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.177 0.822 0.000
E50.2 Vitamin A deficiency with corneal xerosis
0.177 0.822 0.000
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.177 0.822 0.000
E50.0 Vitamin A deficiency with conjunctival xerosis
0.177 0.822 0.000
E63.9 Nutritional deficiency, unspecified
0.177 0.822 0.000
E63.8 Other specified nutritional deficiencies
0.177 0.822 0.000
E63.1 Imbalance of constituents of food intake
0.177 0.822 0.000
E63.0 Essential fatty acid [EFA] deficiency
0.177 0.822 0.000
E64.9 Sequelae of unspecified nutritional deficiency
0.177 0.822 0.000
E64.8 Sequelae of other nutritional deficiencies
0.177 0.822 0.000
E64.3 Sequelae of rickets
0.177 0.822 0.000
E64.2 Sequelae of vitamin C deficiency
0.177 0.822 0.000
E64.1 Sequelae of vitamin A deficiency
0.177 0.822 0.000
E64.0 Sequelae of protein-energy malnutrition
0.177 0.822 0.000
E11.4 With neurological complications
0.173 0.827 0.000
E53 Deficiency of other B group vitamins
0.171 0.829 0.000
E56.9 Vitamin deficiency, unspecified
0.169 0.831 0.000
E56.8 Deficiency of other vitamins
0.169 0.831 0.000
E56.0 Deficiency of vitamin E
0.169 0.831 0.000
E67.8 Other specified hyperalimentation
0.168 0.832 0.000
E67.3 Hypervitaminosis D
0.168 0.832 0.000
E67.2 Megavitamin-B6 syndrome
0.168 0.832 0.000
E67.1 Hypercarotenaemia
0.168 0.832 0.000
E67.0 Hypervitaminosis A
0.168 0.832 0.000
E56.1 Deficiency of vitamin K
0.156 0.843 0.000
E14.9 Without complications
0.149 0.851 0.000
E61.9 Deficiency of nutrient element, unspecified
0.141 0.859 0.000
E61.8 Deficiency of other specified nutrient elements
0.141 0.859 0.000
E61.7 Deficiency of multiple nutrient elements
0.141 0.859 0.000
E61.6 Vanadium deficiency
0.141 0.859 0.000
E61.5 Molybdenum deficiency
0.141 0.859 0.000
E61.4 Chromium deficiency
0.141 0.859 0.000
E61.3 Manganese deficiency
0.141 0.859 0.000
E61.0 Copper deficiency
0.141 0.859 0.000
E55.0 Rickets, active
0.132 0.867 0.000
E53.9 Vitamin B deficiency, unspecified
0.130 0.870 0.000
E61.2 Magnesium deficiency
0.126 0.874 0.000
E53.1 Pyridoxine deficiency
0.123 0.877 0.000
E53.0 Riboflavin deficiency
0.123 0.877 0.000
E83.4 Disorders of magnesium metabolism
0.000 0.879 0.121
E61.1 Iron deficiency
0.112 0.887 0.000
E04 Other non-toxic goitre
0.092 0.902 0.006
K51.9 Ulcerative colitis, unspecified
0.000 0.907 0.093
K51 Ulcerative colitis
0.000 0.910 0.090
K51.4 Pseudopolyposis of colon
0.000 0.914 0.086
K51.3 Ulcerative (chronic) rectosigmoiditis
0.000 0.919 0.081
K51.2 Ulcerative (chronic) proctitis
0.000 0.922 0.078
K51.1 Ulcerative (chronic) ileocolitis
0.000 0.925 0.075
E04.8 Other specified non-toxic goitre
0.066 0.930 0.004
E55.9 Vitamin D deficiency, unspecified
0.070 0.930 0.000
K51.8 Other ulcerative colitis
0.000 0.936 0.064
K51.0 Ulcerative (chronic) enterocolitis
0.000 0.937 0.063
E04.9 Non-toxic goitre, unspecified
0.060 0.939 0.001
C19 Malignant neoplasm of rectosigmoid junction
0.061 0.939 0.000
E06.3 Autoimmune thyroiditis
0.053 0.943 0.004
K51.5 Mucosal proctocolitis
0.000 0.944 0.056
I83 Varicose veins of lower extremities
0.000 0.945 0.055
E04.0 Non-toxic diffuse goitre
0.045 0.950 0.005
E11.9 Without complications
0.041 0.959 0.000
I83.0 Varicose veins of lower extremities with ulcer
0.000 0.962 0.038
I83.2 Varicose veins of lower extremities with both ulcer and inflammation
0.000 0.965 0.034
K90-K93 Other diseases of the digestive system
0.031 0.969 0.000
E83.5 Disorders of calcium metabolism
0.000 0.970 0.030
R31 Unspecified haematuria
0.000 0.971 0.029
E20-E35 Disorders of other endocrine glands
0.024 0.976 0.000
E53.8 Deficiency of other specified B group vitamins
0.024 0.976 0.000
K93 Disorders of other digestive organs in diseases classified elsewhere
0.023 0.977 0.000
E66 Obesity
0.019 0.980 0.000
E32 Diseases of thymus
0.019 0.981 0.000
E24 Cushing's syndrome
0.019 0.981 0.000
E25 Adrenogenital disorders
0.018 0.982 0.000
E20 Hypoparathyroidism
0.018 0.982 0.000
E35 Disorders of endocrine glands in diseases classified elsewhere
0.018 0.982 0.000
E30 Disorders of puberty, not elsewhere classified
0.018 0.982 0.000
E31 Polyglandular dysfunction
0.017 0.983 0.000
K93.8 Disorders of other specified digestive organs in diseases classified elsewhere
0.016 0.983 0.000
K93.1 Megacolon in Chagas' disease
0.016 0.983 0.000
K93.0 Tuberculous disorders of intestines, peritoneum and mesenteric glands
0.016 0.983 0.000
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.016 0.984 0.000
D45 Polycythaemia vera
0.000 0.984 0.016
E24.2 Drug-induced Cushing's syndrome
0.015 0.985 0.000
E32.9 Disease of thymus, unspecified
0.015 0.985 0.000
E24.0 Pituitary-dependent Cushing's disease
0.014 0.986 0.000
E66.1 Drug-induced obesity
0.014 0.986 0.000
E24.8 Other Cushing's syndrome
0.014 0.986 0.000
E21.3 Hyperparathyroidism, unspecified
0.014 0.986 0.000
E32.8 Other diseases of thymus
0.013 0.986 0.000
E32.1 Abscess of thymus
0.013 0.986 0.000
E32.0 Persistent hyperplasia of thymus
0.013 0.986 0.000
E26 Hyperaldosteronism
0.014 0.986 0.000
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.013 0.986 0.000
E24.3 Ectopic ACTH syndrome
0.013 0.986 0.000
E24.1 Nelson's syndrome
0.013 0.986 0.000
E21.4 Other specified disorders of parathyroid gland
0.013 0.987 0.000
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.013 0.987 0.000
E04.1 Non-toxic single thyroid nodule
0.007 0.987 0.006
E20.9 Hypoparathyroidism, unspecified
0.013 0.987 0.000
H40.2 Primary angle-closure glaucoma
0.000 0.987 0.013
E29 Testicular dysfunction
0.013 0.987 0.000
E22 Hyperfunction of pituitary gland
0.013 0.987 0.000
E25.9 Adrenogenital disorder, unspecified
0.013 0.987 0.000
E25.8 Other adrenogenital disorders
0.013 0.987 0.000
E20.8 Other hypoparathyroidism
0.013 0.987 0.000
E20.1 Pseudohypoparathyroidism
0.013 0.987 0.000
E20.0 Idiopathic hypoparathyroidism
0.013 0.987 0.000
E30.9 Disorder of puberty, unspecified
0.013 0.987 0.000
E30.8 Other disorders of puberty
0.013 0.987 0.000
E30.1 Precocious puberty
0.013 0.987 0.000
E30.0 Delayed puberty
0.013 0.987 0.000
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.013 0.987 0.000
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.013 0.987 0.000
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.013 0.987 0.000
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.012 0.988 0.000
E31.9 Polyglandular dysfunction, unspecified
0.012 0.988 0.000
E31.8 Other polyglandular dysfunction
0.012 0.988 0.000
E31.1 Polyglandular hyperfunction
0.012 0.988 0.000
H40.5 Glaucoma secondary to other eye disorders
0.000 0.988 0.012
K40.3 Unilateral or unspecified inguinal hernia, with obstruction, without gangrene
0.011 0.989 0.000
E31.0 Autoimmune polyglandular failure
0.011 0.989 0.000
E28 Ovarian dysfunction
0.011 0.989 0.000
E34 Other endocrine disorders
0.011 0.989 0.000
E04.2 Non-toxic multinodular goitre
0.002 0.989 0.009
E21.2 Other hyperparathyroidism
0.011 0.989 0.000
E24.9 Cushing's syndrome, unspecified
0.010 0.989 0.000
E66.2 Extreme obesity with alveolar hypoventilation
0.010 0.990 0.000
E26.8 Other hyperaldosteronism
0.010 0.990 0.000
E26.1 Secondary hyperaldosteronism
0.010 0.990 0.000
E26.9 Hyperaldosteronism, unspecified
0.010 0.990 0.000
E29.8 Other testicular dysfunction
0.009 0.990 0.000
E29.0 Testicular hyperfunction
0.009 0.990 0.000
E22.9 Hyperfunction of pituitary gland, unspecified
0.009 0.990 0.000
E22.8 Other hyperfunction of pituitary gland
0.009 0.990 0.000
E22.1 Hyperprolactinaemia
0.009 0.990 0.000
E29.9 Testicular dysfunction, unspecified
0.009 0.991 0.000
Z71.8 Other specified counselling
0.000 0.991 0.009
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.009 0.991 0.000
I83.1 Varicose veins of lower extremities with inflammation
0.000 0.991 0.009
K50-K52 Noninfective enteritis and colitis
0.000 0.991 0.009
E66.0 Obesity due to excess calories
0.008 0.991 0.001
E34.3 Short stature, not elsewhere classified
0.008 0.991 0.000
E21.5 Disorder of parathyroid gland, unspecified
0.008 0.991 0.000
E70-E90 Metabolic disorders
0.002 0.991 0.006
K14.8 Other diseases of tongue
0.008 0.992 0.000
E23 Hypofunction and other disorders of pituitary gland
0.008 0.992 0.000
E28.9 Ovarian dysfunction, unspecified
0.008 0.992 0.000
E28.8 Other ovarian dysfunction
0.008 0.992 0.000
E28.1 Androgen excess
0.008 0.992 0.000
E28.0 Oestrogen excess
0.008 0.992 0.000
E34.5 Androgen resistance syndrome
0.008 0.992 0.000
E34.4 Constitutional tall stature
0.008 0.992 0.000
E34.2 Ectopic hormone secretion, not elsewhere classified
0.008 0.992 0.000
E34.1 Other hypersecretion of intestinal hormones
0.008 0.992 0.000
H40 Glaucoma
0.000 0.992 0.008
C20 Malignant neoplasm of rectum
0.008 0.992 0.000
Z87.8 Personal history of other specified conditions
0.000 0.993 0.007
K91 Postprocedural disorders of digestive system, not elsewhere classified
0.007 0.993 0.000
E34.9 Endocrine disorder, unspecified
0.007 0.993 0.000
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.007 0.993 0.000
E26.0 Primary hyperaldosteronism
0.006 0.993 0.000
E84 Cystic fibrosis
0.001 0.993 0.005
E34.8 Other specified endocrine disorders
0.006 0.994 0.000
K91.0 Vomiting following gastro-intestinal surgery
0.006 0.994 0.000
E70 Disorders of aromatic amino-acid metabolism
0.002 0.994 0.005
E79 Disorders of purine and pyrimidine metabolism
0.002 0.994 0.005
E77 Disorders of glycoprotein metabolism
0.002 0.994 0.005
E76 Disorders of glycosaminoglycan metabolism
0.002 0.994 0.005
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.002 0.994 0.005
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.002 0.994 0.005
E72 Other disorders of amino-acid metabolism
0.002 0.994 0.005
E28.3 Primary ovarian failure
0.006 0.994 0.000
E23.1 Drug-induced hypopituitarism
0.006 0.994 0.000
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.002 0.994 0.005
E34.0 Carcinoid syndrome
0.006 0.994 0.000
E22.0 Acromegaly and pituitary gigantism
0.006 0.994 0.000
E85 Amyloidosis
0.001 0.994 0.005
K91.9 Postprocedural disorder of digestive system, unspecified
0.006 0.994 0.000
H40.4 Glaucoma secondary to eye inflammation
0.000 0.994 0.006
H40.6 Glaucoma secondary to drugs
0.000 0.994 0.006
K91.1 Postgastric surgery syndromes
0.006 0.994 0.000
C15-C26 Malignant neoplasms of digestive organs
0.006 0.994 0.000
L90.0 Lichen sclerosus et atrophicus
0.000 0.994 0.006
E23.2 Diabetes insipidus
0.006 0.994 0.000
E03.9 Hypothyroidism, unspecified
0.006 0.994 0.000
E74 Other disorders of carbohydrate metabolism
0.002 0.994 0.004
E73 Lactose intolerance
0.002 0.994 0.004
C15 Malignant neoplasm of oesophagus
0.006 0.994 0.000
H40.3 Glaucoma secondary to eye trauma
0.000 0.994 0.006
E29.1 Testicular hypofunction
0.005 0.994 0.000
E80 Disorders of porphyrin and bilirubin metabolism
0.001 0.994 0.005
C15.4 Middle third of oesophagus
0.005 0.994 0.000
E28.2 Polycystic ovarian syndrome
0.005 0.995 0.000
E23.7 Disorder of pituitary gland, unspecified
0.005 0.995 0.000
H40.8 Other glaucoma
0.000 0.995 0.005
E84.9 Cystic fibrosis, unspecified
0.001 0.995 0.004
E27 Other disorders of adrenal gland
0.005 0.995 0.000
C15.5 Lower third of oesophagus
0.005 0.995 0.000
E85.9 Amyloidosis, unspecified
0.001 0.995 0.005
K91.2 Postsurgical malabsorption, not elsewhere classified
0.005 0.995 0.000
E84.8 Cystic fibrosis with other manifestations
0.001 0.995 0.004
E84.1 Cystic fibrosis with intestinal manifestations
0.001 0.995 0.004
E84.0 Cystic fibrosis with pulmonary manifestations
0.001 0.995 0.004
C24 Malignant neoplasm of other and unspecified parts of biliary tract
0.005 0.995 0.000
C24.0 Extrahepatic bile duct
0.005 0.995 0.000
E75.2 Other sphingolipidosis
0.001 0.995 0.004
E70.3 Albinism
0.001 0.995 0.004
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.001 0.995 0.004
E70.8 Other disorders of aromatic amino-acid metabolism
0.001 0.995 0.004
E70.2 Disorders of tyrosine metabolism
0.001 0.995 0.004
E70.1 Other hyperphenylalaninaemias
0.001 0.995 0.004
E70.0 Classical phenylketonuria
0.001 0.995 0.004
E71.3 Disorders of fatty-acid metabolism
0.001 0.995 0.003
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.001 0.995 0.003
E71.1 Other disorders of branched-chain amino-acid metabolism
0.001 0.995 0.003
E71.0 Maple-syrup-urine disease
0.001 0.995 0.003
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.001 0.995 0.003
E76.8 Other disorders of glucosaminoglycan metabolism
0.001 0.995 0.003
E76.3 Mucopolysaccharidosis, unspecified
0.001 0.995 0.003
E76.2 Other mucopolysaccharidoses
0.001 0.995 0.003
E76.1 Mucopolysaccharidosis, type II
0.001 0.995 0.003
E76.0 Mucopolysaccharidosis, type I
0.001 0.995 0.003
E77.9 Disorder of glycoprotein metabolism, unspecified
0.001 0.995 0.003
E77.8 Other disorders of glycoprotein metabolism
0.001 0.995 0.003
E77.1 Defects in glycoprotein degradation
0.001 0.995 0.003
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.001 0.995 0.003
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.001 0.995 0.004
E79.8 Other disorders of purine and pyrimidine metabolism
0.001 0.995 0.004
E79.1 Lesch-Nyhan syndrome
0.001 0.995 0.004
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.001 0.995 0.004
E72.9 Disorder of amino-acid metabolism, unspecified
0.001 0.995 0.003
E72.8 Other specified disorders of amino-acid metabolism
0.001 0.995 0.003
E72.5 Disorders of glycine metabolism
0.001 0.995 0.003
E72.4 Disorders of ornithine metabolism
0.001 0.995 0.003
E72.3 Disorders of lysine and hydroxylysine metabolism
0.001 0.995 0.003
E72.2 Disorders of urea cycle metabolism
0.001 0.995 0.003
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.001 0.995 0.003
E72.0 Disorders of amino-acid transport
0.001 0.995 0.003
E75.6 Lipid storage disorder, unspecified
0.001 0.995 0.003
E75.4 Neuronal ceroid lipofuscinosis
0.001 0.995 0.003
E75.3 Sphingolipidosis, unspecified
0.001 0.995 0.003
E75.1 Other gangliosidosis
0.001 0.995 0.003
E75.0 GM2 gangliosidosis
0.001 0.995 0.003
E85.2 Heredofamilial amyloidosis, unspecified
0.001 0.995 0.004
E85.1 Neuropathic heredofamilial amyloidosis
0.001 0.995 0.004
E85.0 Nonneuropathic heredofamilial amyloidosis
0.001 0.995 0.004
E85.3 Secondary systemic amyloidosis
0.001 0.995 0.004
E23.6 Other disorders of pituitary gland
0.004 0.995 0.000
E88 Other metabolic disorders
0.001 0.995 0.003
E75.5 Other lipid storage disorders
0.001 0.995 0.003
E80.6 Other disorders of bilirubin metabolism
0.001 0.995 0.004
E80.1 Porphyria cutanea tarda
0.001 0.995 0.004
E74.9 Disorder of carbohydrate metabolism, unspecified
0.001 0.996 0.003
E74.8 Other specified disorders of carbohydrate metabolism
0.001 0.996 0.003
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.001 0.996 0.003
E74.2 Disorders of galactose metabolism
0.001 0.996 0.003
E74.1 Disorders of fructose metabolism
0.001 0.996 0.003
E85.8 Other amyloidosis
0.001 0.996 0.003
K04.6 Periapical abscess with sinus
0.004 0.996 0.000
E73.8 Other lactose intolerance
0.001 0.996 0.003
E73.1 Secondary lactase deficiency
0.001 0.996 0.003
E73.0 Congenital lactase deficiency
0.001 0.996 0.003
C15.8 Overlapping lesion of oesophagus
0.004 0.996 0.000
C15.2 Abdominal part of oesophagus
0.004 0.996 0.000
C15.9 Oesophagus, unspecified
0.004 0.996 0.000
E27.1 Primary adrenocortical insufficiency
0.004 0.996 0.000
H40.0 Glaucoma suspect
0.000 0.996 0.004
H66.3 Other chronic suppurative otitis media
0.000 0.996 0.004
E74.0 Glycogen storage disease
0.001 0.996 0.003
E80.5 Crigler-Najjar syndrome
0.001 0.996 0.003
E80.3 Defects of catalase and peroxydase
0.001 0.996 0.003
E80.0 Hereditary erythropoietic porphyria
0.001 0.996 0.003
C25 Malignant neoplasm of pancreas
0.004 0.996 0.000
C15.0 Cervical part of oesophagus
0.004 0.996 0.000
C15.1 Thoracic part of oesophagus
0.004 0.996 0.000
S02.00 Fracture of vault of skull (closed)
0.004 0.996 0.000
E74.3 Other disorders of intestinal carbohydrate absorption
0.001 0.996 0.003
E27.5 Adrenomedullary hyperfunction
0.004 0.996 0.000
E27.0 Other adrenocortical overactivity
0.004 0.996 0.000
C24.9 Biliary tract, unspecified
0.004 0.996 0.000
S02.40 Fracture of malar and maxillary bones (closed)
0.004 0.996 0.000
E80.7 Disorder of bilirubin metabolism, unspecified
0.001 0.996 0.003
K91.3 Postoperative intestinal obstruction
0.004 0.996 0.000
E85.4 Organ-limited amyloidosis
0.001 0.996 0.003
C24.8 Overlapping lesion of biliary tract
0.004 0.996 0.000
C25.1 Body of pancreas
0.004 0.996 0.000
K50 Crohn's disease [regional enteritis]
0.000 0.996 0.004
M24.16 Other articular cartilage disorders (Lower leg)
0.004 0.996 0.000
S62.30 Fracture of other metacarpal bone (closed)
0.004 0.996 0.000
E80.2 Other porphyria
0.001 0.996 0.003
C15.3 Upper third of oesophagus
0.004 0.996 0.000
E73.9 Lactose intolerance, unspecified
0.001 0.996 0.003
K50.8 Other Crohn's disease
0.000 0.996 0.004
C25.3 Pancreatic duct
0.004 0.996 0.000
C25.8 Overlapping lesion of pancreas
0.004 0.996 0.000
E88.3 Tumour lysis syndrome
0.001 0.996 0.003
M70.65 Trochanteric bursitis-Pelvic/Thigh
0.004 0.996 0.000
K91.5 Postcholecystectomy syndrome
0.003 0.996 0.000
L03.3 Cellulitis of trunk
0.000 0.996 0.004
K14 Diseases of tongue
0.004 0.996 0.000
E80.4 Gilbert's syndrome
0.000 0.996 0.003
E27.3 Drug-induced adrenocortical insufficiency
0.003 0.996 0.000
F23.9 Acute and transient psychotic disorder, unspecified
0.004 0.996 0.000
E88.8 Other specified metabolic disorders
0.001 0.996 0.003
C25.4 Endocrine pancreas
0.003 0.997 0.000
E88.1 Lipodystrophy, not elsewhere classified
0.001 0.997 0.002
H40-H42 Glaucoma
0.000 0.997 0.003
C17 Malignant neoplasm of small intestine
0.003 0.997 0.000
S02.0 Fracture of vault of skull
0.003 0.997 0.000
K14.6 Glossodynia
0.003 0.997 0.000
C25.2 Tail of pancreas
0.003 0.997 0.000
N60.2 Fibroadenosis of breast
0.000 0.997 0.003
E27.2 Addisonian crisis
0.003 0.997 0.000
E88.2 Lipomatosis, not elsewhere classified
0.001 0.997 0.002
F50.0 Anorexia nervosa
0.003 0.997 0.000
C26 Malignant neoplasm of other and ill-defined digestive organs
0.003 0.997 0.000
E88.9 Metabolic disorder, unspecified
0.002 0.997 0.002
I97.2 Postmastectomy lymphoedema syndrome
0.003 0.997 0.000
E27.4 Other and unspecified adrenocortical insufficiency
0.003 0.997 0.000
S02.4 Fracture of malar and maxillary bones
0.003 0.997 0.000
E23.0 Hypopituitarism
0.003 0.997 0.000
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.001 0.997 0.003
K14.3 Hypertrophy of tongue papillae
0.003 0.997 0.000
C25.7 Other parts of pancreas
0.003 0.997 0.000
T93.3 Sequelae of dislocation, sprain and strain of lower limb
0.000 0.997 0.003
F50.2 Bulimia nervosa
0.003 0.997 0.000
R47.0 Dysphasia and aphasia
0.003 0.997 0.000
M45.X9 Ankylosing spondylitis (Site unspecified)
0.000 0.997 0.003
L40.0 Psoriasis vulgaris
0.003 0.997 0.000
F50 Eating disorders
0.003 0.997 0.000
H53.2 Diplopia
0.003 0.997 0.000
K14.5 Plicated tongue
0.003 0.997 0.000
K14.4 Atrophy of tongue papillae
0.003 0.997 0.000
K14.2 Median rhomboid glossitis
0.003 0.997 0.000
K14.1 Geographic tongue
0.003 0.997 0.000
S27.20 Traumatic haemopneumothorax (without open wound into thoracic cavity)
0.003 0.997 0.000
J93.8 Other pneumothorax
0.003 0.997 0.000
C17.1 Jejunum
0.003 0.997 0.000
E27.9 Disorder of adrenal gland, unspecified
0.002 0.997 0.000
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.997 0.002
H42 Glaucoma in diseases classified elsewhere
0.000 0.997 0.003
C17.0 Duodenum
0.003 0.997 0.000
C23 Malignant neoplasm of gallbladder
0.002 0.997 0.000
S02.01 Fracture of vault of skull (open)
0.002 0.997 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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