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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs1475865
log Bayes Factor = 169.543
Chromosome 6   position 31,657,413  (GRCh37) Explore rs1475865 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.000 1.000
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.000 1.000
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
E10.9 Without complications
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.000 1.000
E10.1 With ketoacidosis
0.000 0.000 1.000
H36.0 Diabetic retinopathy
0.000 0.000 1.000
K90.0 Coeliac disease
0.000 0.000 1.000
L40.9 Psoriasis, unspecified
0.000 0.000 1.000
L40.5 Arthropathic psoriasis
0.000 0.000 1.000
M06.9 Rheumatoid arthritis, unspecified
0.000 0.000 1.000
E11 Non-insulin-dependent diabetes mellitus
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
G35 Multiple sclerosis
1.000 0.000 0.000
I25 Chronic ischaemic heart disease
0.000 0.000 1.000
L40 Psoriasis
0.000 0.000 1.000
M06 Other rheumatoid arthritis
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
I20-I25 Ischaemic heart diseases
0.000 0.000 1.000
M05-M14 Inflammatory polyarthropathies
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
E14 Unspecified diabetes mellitus
0.000 0.000 1.000
L40-L45 Papulosquamous disorders
0.000 0.000 1.000
E11.9 Without complications
0.000 0.000 1.000
# Top node
0.000 0.000 1.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.000 0.000 1.000
E10.4 With neurological complications
0.000 0.000 1.000
I25.1 Atherosclerotic heart disease
0.000 0.000 1.000
H36 Retinal disorders in diseases classified elsewhere
0.000 0.000 1.000
H30-H36 Disorders of choroid and retina
0.000 0.000 1.000
E03 Other hypothyroidism
0.000 0.000 1.000
M05 Seropositive rheumatoid arthritis
0.000 0.000 1.000
M05.9 Seropositive rheumatoid arthritis, unspecified
0.000 0.000 1.000
I20 Angina pectoris
0.000 0.000 1.000
D64.9 Anaemia, unspecified
0.000 0.000 1.000
I20.9 Angina pectoris, unspecified
0.000 0.000 1.000
L43 Lichen planus
0.000 0.001 0.999
M45 Ankylosing spondylitis
0.000 0.001 0.999
M45.X9 Ankylosing spondylitis (Site unspecified)
0.000 0.001 0.999
E83.1 Disorders of iron metabolism
0.999 0.001 0.000
M07 Psoriatic and enteropathic arthropathies
0.000 0.001 0.999
Chapter VII Diseases of the eye and adnexa
0.000 0.001 0.999
I22 Subsequent myocardial infarction
0.000 0.001 0.999
L43.9 Lichen planus, unspecified
0.000 0.001 0.999
E11.3 With ophthalmic complications
0.000 0.001 0.999
M07.3 Other psoriatic arthropathies
0.000 0.001 0.999
E14.9 Without complications
0.000 0.002 0.998
E14.3 With ophthalmic complications
0.000 0.002 0.998
M45-M49 Spondylopathies
0.000 0.002 0.998
M05.90 Seropositive rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.003 0.997
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.003 0.997
Chapter IX Diseases of the circulatory system
0.000 0.005 0.995
Chapter XII Diseases of the skin and subcutaneous tissue
0.000 0.006 0.994
G35-G37 Demyelinating diseases of the central nervous system
0.991 0.006 0.003
M07.39 Other psoriatic arthropathies (Site unspecified)
0.000 0.007 0.993
E10.5 With peripheral circulatory complications
0.000 0.007 0.993
I22.1 Subsequent myocardial infarction of inferior wall
0.000 0.008 0.992
I21 Acute myocardial infarction
0.000 0.009 0.991
M05.99 Seropositive rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.010 0.990
G37 Other demyelinating diseases of central nervous system
0.988 0.011 0.001
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.000 0.011 0.989
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.000 0.013 0.987
E78.0 Pure hypercholesterolaemia
0.000 0.014 0.986
G37.9 Demyelinating disease of central nervous system, unspecified
0.986 0.014 0.000
D64 Other anaemias
0.000 0.014 0.986
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.014 0.986
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.015 0.985
E70-E90 Metabolic disorders
0.000 0.017 0.983
H43-H45 Disorders of vitreous body and globe
0.000 0.017 0.983
D60-D64 Aplastic and other anaemias
0.000 0.020 0.980
I21.2 Acute transmural myocardial infarction of other sites
0.000 0.021 0.979
I25.8 Other forms of chronic ischaemic heart disease
0.000 0.021 0.979
H43 Disorders of vitreous body
0.000 0.021 0.979
M06.0 Seronegative rheumatoid arthritis
0.000 0.022 0.978
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.000 0.023 0.977
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.024 0.976
E16 Other disorders of pancreatic internal secretion
0.000 0.025 0.975
I21.9 Acute myocardial infarction, unspecified
0.000 0.025 0.975
E06 Thyroiditis
0.000 0.026 0.974
I20.0 Unstable angina
0.000 0.028 0.972
M35.3 Polymyalgia rheumatica
0.000 0.029 0.971
E05.9 Thyrotoxicosis, unspecified
0.000 0.032 0.968
E16.2 Hypoglycaemia, unspecified
0.000 0.032 0.968
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.000 0.033 0.967
M35 Other systemic involvement of connective tissue
0.000 0.035 0.965
M07.30 Other psoriatic arthropathies (Multiple sites)
0.000 0.036 0.964
I25.5 Ischaemic cardiomyopathy
0.000 0.037 0.963
I10-I15 Hypertensive diseases
0.000 0.037 0.963
I22.9 Subsequent myocardial infarction of unspecified site
0.000 0.039 0.961
E10.2 With renal complications
0.000 0.040 0.960
M20-M25 Other joint disorders
0.000 0.041 0.959
H34 Retinal vascular occlusions
0.000 0.042 0.958
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.045 0.955
I24 Other acute ischaemic heart diseases
0.000 0.045 0.955
E11.5 With peripheral circulatory complications
0.000 0.045 0.955
M06.09 Seronegative rheumatoid arthritis (Site unspecified)
0.000 0.048 0.952
E06.3 Autoimmune thyroiditis
0.000 0.048 0.952
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.056 0.944
H43.8 Other disorders of vitreous body
0.000 0.064 0.936
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.000 0.068 0.932
L40.0 Psoriasis vulgaris
0.000 0.068 0.932
I12 Hypertensive renal disease
0.000 0.070 0.930
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.073 0.927
E78.2 Mixed hyperlipidaemia
0.000 0.076 0.924
M06.3 Rheumatoid nodule
0.000 0.078 0.922
E10.0 With coma
0.000 0.081 0.919
E10.8 With unspecified complications
0.000 0.087 0.913
E10.6 With other specified complications
0.000 0.090 0.910
I12.9 Hypertensive renal disease without renal failure
0.000 0.090 0.910
E11.1 With ketoacidosis
0.000 0.090 0.910
H34.8 Other retinal vascular occlusions
0.000 0.095 0.905
I24.0 Coronary thrombosis not resulting in myocardial infarction
0.000 0.103 0.897
M06.00 Seronegative rheumatoid arthritis (Multiple sites)
0.000 0.107 0.893
I83.9 Varicose veins of lower extremities without ulcer or inflammation
0.883 0.117 0.000
M45.X2 Ankylosing spondylitis (Cervical region)
0.000 0.130 0.870
L43.8 Other lichen planus
0.000 0.138 0.862
I24.9 Acute ischaemic heart disease, unspecified
0.000 0.141 0.859
H43.3 Other vitreous opacities
0.000 0.144 0.856
L40.8 Other psoriasis
0.000 0.145 0.855
H30 Chorioretinal inflammation
0.000 0.146 0.854
E78.8 Other disorders of lipoprotein metabolism
0.000 0.152 0.848
M34 Systemic sclerosis
0.000 0.154 0.846
I15 Secondary hypertension
0.000 0.157 0.843
H15-H22 Disorders of sclera, cornea, iris and ciliary body
0.000 0.159 0.841
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.159 0.841
H43.1 Vitreous haemorrhage
0.000 0.170 0.830
M35.7 Hypermobility syndrome
0.000 0.171 0.829
H35 Other retinal disorders
0.000 0.171 0.829
H43.2 Crystalline deposits in vitreous body
0.000 0.172 0.828
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.000 0.172 0.828
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.173 0.827
G37.8 Other specified demyelinating diseases of central nervous system
0.815 0.185 0.000
I22.0 Subsequent myocardial infarction of anterior wall
0.000 0.185 0.815
H43.9 Disorder of vitreous body, unspecified
0.000 0.188 0.812
H33 Retinal detachments and breaks
0.000 0.191 0.809
M07.36 Other psoriatic arthropathies (Lower leg)
0.000 0.196 0.804
E14.6 With other specified complications
0.000 0.200 0.800
M05.96 Seropositive rheumatoid arthritis, unspecified (Lower leg)
0.000 0.201 0.799
H35.8 Other specified retinal disorders
0.000 0.202 0.798
H20 Iridocyclitis
0.000 0.205 0.795
M06.34 Rheumatoid nodule (Hand)
0.000 0.207 0.793
E11.2 With renal complications
0.000 0.209 0.791
E78.4 Other hyperlipidaemia
0.000 0.211 0.789
M34.1 CR(E)ST syndrome
0.000 0.211 0.789
E74 Other disorders of carbohydrate metabolism
0.000 0.212 0.788
H33.2 Serous retinal detachment
0.000 0.214 0.786
M07.34 Other psoriatic arthropathies (Hand)
0.000 0.216 0.784
E14.5 With peripheral circulatory complications
0.000 0.217 0.783
M06.32 Rheumatoid nodule (Upper arm)
0.000 0.220 0.780
I05-I09 Chronic rheumatic heart diseases
0.000 0.223 0.777
E11.0 With coma
0.000 0.224 0.776
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.224 0.776
M05.97 Seropositive rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.225 0.775
H34.2 Other retinal artery occlusions
0.000 0.230 0.770
I25.3 Aneurysm of heart
0.000 0.231 0.768
H35.4 Peripheral retinal degeneration
0.000 0.232 0.768
M35.1 Other overlap syndromes
0.000 0.242 0.758
M14 Arthropathies in other diseases classified elsewhere
0.000 0.244 0.756
M06.98 Rheumatoid arthritis, unspecified (Other)
0.000 0.245 0.754
K90 Intestinal malabsorption
0.000 0.248 0.752
H30.9 Chorioretinal inflammation, unspecified
0.000 0.250 0.750
E14.1 With ketoacidosis
0.000 0.252 0.748
M65-M68 Disorders of synovium and tendon
0.000 0.253 0.747
M07.37 Other psoriatic arthropathies (Ankle and foot)
0.000 0.255 0.745
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.256 0.744
E11.4 With neurological complications
0.000 0.257 0.743
M49 Spondylopathies in diseases classified elsewhere
0.000 0.257 0.743
I15.1 Hypertension secondary to other renal disorders
0.000 0.268 0.732
Chapter VI Diseases of the nervous system
0.076 0.269 0.655
I25.9 Chronic ischaemic heart disease, unspecified
0.000 0.270 0.730
I10 Essential (primary) hypertension
0.000 0.274 0.726
M12 Other specific arthropathies
0.000 0.274 0.726
I00-I02 Acute rheumatic fever
0.000 0.278 0.722
E06.5 Other chronic thyroiditis
0.000 0.278 0.722
M30 Polyarteritis nodosa and related conditions
0.000 0.282 0.718
E10.7 With multiple complications
0.000 0.283 0.717
E11.7 With multiple complications
0.000 0.283 0.717
E14.8 With unspecified complications
0.000 0.283 0.717
E14.7 With multiple complications
0.000 0.283 0.717
E14.0 With coma
0.000 0.283 0.717
I25.6 Silent myocardial ischaemia
0.000 0.283 0.717
L40.4 Guttate psoriasis
0.000 0.283 0.717
L40.2 Acrodermatitis continua
0.000 0.283 0.717
L40.1 Generalised pustular psoriasis
0.000 0.283 0.717
M06.8 Other specified rheumatoid arthritis
0.000 0.283 0.717
M06.2 Rheumatoid bursitis
0.000 0.283 0.717
M06.1 Adult-onset Still's disease
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
M09 Juvenile arthritis in diseases classified elsewhere
0.000 0.283 0.717
M08 Juvenile arthritis
0.000 0.283 0.717
L44 Other papulosquamous disorders
0.000 0.283 0.717
L41 Parapsoriasis
0.000 0.283 0.717
L45 Papulosquamous disorders in diseases classified elsewhere
0.000 0.283 0.717
Chapter XVI Certain conditions originating in the perinatal period
0.000 0.283 0.717
M06.37 Rheumatoid nodule (Ankle and foot)
0.000 0.283 0.717
H36.8 Other retinal disorders in diseases classified elsewhere
0.000 0.283 0.717
M05.8 Other seropositive rheumatoid arthritis
0.000 0.283 0.717
M05.3 Rheumatoid arthritis with involvement of other organs and systems
0.000 0.283 0.717
M05.2 Rheumatoid vasculitis
0.000 0.283 0.717
M05.1 Rheumatoid lung disease
0.000 0.283 0.717
M05.0 Felty's syndrome
0.000 0.283 0.717
H32 Chorioretinal disorders in diseases classified elsewhere
0.000 0.283 0.717
M05.98 Seropositive rheumatoid arthritis, unspecified (Other)
0.000 0.283 0.717
M05.95 Seropositive rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.283 0.717
M05.94 Seropositive rheumatoid arthritis, unspecified (Hand)
0.000 0.283 0.717
M05.93 Seropositive rheumatoid arthritis, unspecified (Forearm)
0.000 0.283 0.717
M05.92 Seropositive rheumatoid arthritis, unspecified (Upper arm)
0.000 0.283 0.717
M05.91 Seropositive rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.283 0.717
E03.5 Myxoedema coma
0.000 0.283 0.717
E03.4 Atrophy of thyroid (acquired)
0.000 0.283 0.717
E03.3 Postinfectious hypothyroidism
0.000 0.283 0.717
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.283 0.717
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)
0.000 0.283 0.717
M45.X7 Ankylosing spondylitis (Lumbosacral region)
0.000 0.283 0.717
M45.X6 Ankylosing spondylitis (Lumbar region)
0.000 0.283 0.717
M45.X5 Ankylosing spondylitis (Thoracolumbar region)
0.000 0.283 0.717
M45.X4 Ankylosing spondylitis (Thoracic region)
0.000 0.283 0.717
M45.X3 Ankylosing spondylitis (Cervicothoracic region)
0.000 0.283 0.717
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)
0.000 0.283 0.717
L43.3 Subacute (active) lichen planus
0.000 0.283 0.717
L43.2 Lichenoid drug reaction
0.000 0.283 0.717
L43.1 Bullous lichen planus
0.000 0.283 0.717
L43.0 Hypertrophic lichen planus
0.000 0.283 0.717
M07.6 Other enteropathic arthropathies
0.000 0.284 0.716
M07.5 Arthropathy in ulcerative colitis
0.000 0.284 0.716
M07.4 Arthropathy in Crohn's disease [regional enteritis]
0.000 0.284 0.716
M07.2 Psoriatic spondylitis
0.000 0.284 0.716
M07.1 Arthritis mutilans
0.000 0.284 0.716
M07.0 Distal interphalangeal psoriatic arthropathy
0.000 0.284 0.716
H34.9 Retinal vascular occlusion, unspecified
0.000 0.284 0.716
M07.38 Other psoriatic arthropathies (Other)
0.000 0.284 0.716
M07.33 Other psoriatic arthropathies (Forearm)
0.000 0.284 0.716
M07.32 Other psoriatic arthropathies (Upper arm)
0.000 0.284 0.716
M06.4 Inflammatory polyarthropathy
0.000 0.284 0.715
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.285 0.715
E05.5 Thyroid crisis or storm
0.000 0.285 0.715
E05.4 Thyrotoxicosis factitia
0.000 0.285 0.715
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.285 0.715
M65 Synovitis and tenosynovitis
0.000 0.286 0.714
M25 Other joint disorders, not elsewhere classified
0.000 0.286 0.714
E06.9 Thyroiditis, unspecified
0.000 0.286 0.714
G36 Other acute disseminated demyelination
0.710 0.288 0.002
H34.1 Central retinal artery occlusion
0.000 0.288 0.712
H20.9 Iridocyclitis, unspecified
0.000 0.288 0.712
E13 Other specified diabetes mellitus
0.000 0.289 0.711
I21.X Presumed acute myicardial infaction (unconfirmed)
0.000 0.290 0.710
E11.6 With other specified complications
0.000 0.290 0.710
G37.5 Concentric sclerosis [Balo]
0.709 0.291 0.001
G37.4 Subacute necrotising myelitis
0.709 0.291 0.001
G37.2 Central pontine myelinolysis
0.709 0.291 0.001
G37.1 Central demyelination of corpus callosum
0.709 0.291 0.001
G37.0 Diffuse sclerosis
0.709 0.291 0.001
E78.6 Lipoprotein deficiency
0.000 0.292 0.708
I23 Certain current complications following acute myocardial infarction
0.000 0.292 0.708
D64.4 Congenital dyserythropoietic anaemia
0.000 0.293 0.707
D64.3 Other sideroblastic anaemias
0.000 0.293 0.707
D64.2 Secondary sideroblastic anaemia due to drugs and toxins
0.000 0.293 0.707
D64.1 Secondary sideroblastic anaemia due to disease
0.000 0.293 0.707
D64.0 Hereditary sideroblastic anaemia
0.000 0.293 0.707
E15 Nondiabetic hypoglycaemic coma
0.000 0.293 0.707
E40-E46 Malnutrition
0.000 0.294 0.706
E78.3 Hyperchylomicronaemia
0.000 0.294 0.706
E77 Disorders of glycoprotein metabolism
0.000 0.295 0.705
E76 Disorders of glycosaminoglycan metabolism
0.000 0.295 0.705
E72 Other disorders of amino-acid metabolism
0.000 0.295 0.705
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.295 0.705
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.295 0.705
H45 Disorders of vitreous body and globe in diseases classified elsewhere
0.000 0.295 0.705
E79 Disorders of purine and pyrimidine metabolism
0.000 0.296 0.704
D60 Acquired pure red cell aplasia [erythroblastopenia]
0.000 0.297 0.702
E70 Disorders of aromatic amino-acid metabolism
0.000 0.298 0.702
M06.08 Seronegative rheumatoid arthritis (Other)
0.000 0.299 0.701
M06.05 Seronegative rheumatoid arthritis (Pelvic region and thigh)
0.000 0.299 0.701
M06.04 Seronegative rheumatoid arthritis (Hand)
0.000 0.299 0.701
M06.03 Seronegative rheumatoid arthritis (Forearm)
0.000 0.299 0.701
M06.02 Seronegative rheumatoid arthritis (Upper arm)
0.000 0.299 0.701
M06.01 Seronegative rheumatoid arthritis (Shoulder region)
0.000 0.299 0.701
M25.4 Effusion of joint
0.000 0.300 0.700
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.301 0.699
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.301 0.699
E16.4 Abnormal secretion of gastrin
0.000 0.301 0.699
E16.3 Increased secretion of glucagon
0.000 0.301 0.699
E06.4 Drug-induced thyroiditis
0.000 0.302 0.698
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.302 0.698
E06.1 Subacute thyroiditis
0.000 0.302 0.698
E06.0 Acute thyroiditis
0.000 0.302 0.698
K90-K93 Other diseases of the digestive system
0.000 0.302 0.698
H15 Disorders of sclera
0.000 0.302 0.698
M35.2 Behcet's disease
0.000 0.303 0.697
L55-L59 Radiation-related disorders of the skin and subcutaneous tissue
0.000 0.305 0.695
K70-K77 Diseases of liver
0.000 0.306 0.694
Chapter XI Diseases of the digestive system
0.000 0.307 0.693
M35.9 Systemic involvement of connective tissue, unspecified
0.000 0.308 0.692
M35.6 Relapsing panniculitis [Weber-Christian]
0.000 0.308 0.692
M35.5 Multifocal fibrosclerosis
0.000 0.308 0.692
M35.4 Diffuse (eosinophilic) fasciitis
0.000 0.308 0.692
D62 Acute posthaemorrhagic anaemia
0.000 0.309 0.691
M25.46 Effusion of joint (Lower leg)
0.000 0.310 0.690
E89.3 Postprocedural hypopituitarism
0.000 0.311 0.689
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.000 0.312 0.688
H34.0 Transient retinal artery occlusion
0.000 0.313 0.687
H46-H48 Disorders of optic nerve and visual pathways
0.000 0.313 0.687
M33 Dermatopolymyositis
0.000 0.314 0.686
K75 Other inflammatory liver diseases
0.000 0.314 0.686
I25.0 Atherosclerotic cardiovascular disease, so described
0.000 0.314 0.686
K75.4 Autoimmune hepatitis
0.000 0.316 0.684
H43.0 Vitreous prolapse
0.000 0.323 0.677
M65.4 Radial styloid tenosynovitis [de Quervain]
0.000 0.325 0.675
M80-M85 Disorders of bone density and structure
0.000 0.326 0.674
K74 Fibrosis and cirrhosis of liver
0.000 0.327 0.673
E14.2 Withrenal complications
0.000 0.328 0.672
H20.0 Acute and subacute iridocyclitis
0.000 0.328 0.672
D61 Other aplastic anaemias
0.000 0.329 0.671
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.670 0.330 0.001
L10-L14 Bullous disorders
0.000 0.330 0.670
H19 Disorders of sclera and cornea in diseases classified elsewhere
0.000 0.331 0.669
E14.4 With neurological complications
0.000 0.332 0.667
D50-D53 Nutritional anaemias
0.000 0.335 0.665
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.338 0.661
M06.39 Rheumatoid nodule (Site unspecified)
0.000 0.339 0.661
M06.38 Rheumatoid nodule (Other)
0.000 0.339 0.661
M06.36 Rheumatoid nodule (Lower leg)
0.000 0.339 0.661
M06.35 Rheumatoid nodule (Pelvic region and thigh)
0.000 0.339 0.661
M06.33 Rheumatoid nodule (Forearm)
0.000 0.339 0.661
M06.31 Rheumatoid nodule (Shoulder region)
0.000 0.339 0.661
K74.3 Primary biliary cirrhosis
0.000 0.341 0.659
H33.0 Retinal detachment with retinal break
0.000 0.342 0.658
I15.9 Seconday hypertension, unspecified
0.000 0.343 0.657
M06.30 Rheumatoid nodule (Multiple sites)
0.000 0.344 0.656
L42 Pityriasis rosea
0.000 0.345 0.655
E78.1 Pure hyperglyceridaemia
0.000 0.346 0.654
M07.31 Other psoriatic arthropathies (Shoulder region)
0.000 0.349 0.651
M07.35 Other psoriatic arthropathies (Pelvic region and thigh)
0.000 0.351 0.648
H35.2 Other proliferative retinopathy
0.000 0.352 0.648
E74.3 Other disorders of intestinal carbohydrate absorption
0.000 0.353 0.647
I13 Hypertensive heart and renal disease
0.000 0.353 0.646
M14.6 Neuropathic arthropathy
0.000 0.354 0.646
I09 Other rheumatic heart diseases
0.000 0.355 0.645
M25.6 Stiffness of joint, not elsewhere classified
0.000 0.355 0.645
H21 Other disorders of iris and ciliary body
0.000 0.355 0.645
G50-G59 Nerve, nerve root and plexus disorders
0.008 0.356 0.636
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.356 0.644
I25.2 Old myocardial infarction
0.000 0.357 0.643
I08 Multiple valve diseases
0.000 0.357 0.643
I22.8 Subsequent myocardial infarction of other sites
0.000 0.358 0.642
E11.8 With unspecified complications
0.000 0.359 0.641
H22 Disorders of iris and ciliary body in diseases classified elsewhere
0.000 0.361 0.639
E83 Disorders of mineral metabolism
0.556 0.362 0.081
E84 Cystic fibrosis
0.000 0.363 0.637
E07 Other disorders of thyroid
0.000 0.364 0.636
G70-G73 Diseases of myoneural junction and muscle
0.017 0.364 0.619
G59 Mononeuropathy in diseases classified elsewhere
0.004 0.365 0.631
H20.8 Other iridocyclitis
0.000 0.365 0.634
H55-H59 Other disorders of eye and adnexa
0.000 0.366 0.634
I24.8 Other forms of acute ischaemic heart disease
0.000 0.368 0.632
G56.0 Carpal tunnel syndrome
0.000 0.369 0.631
G56 Mononeuropathies of upper limb
0.001 0.369 0.630
I12.0 Hypertensive renal disease with renal failure
0.000 0.371 0.629
G59.0 Diabetic mononeuropathy
0.000 0.371 0.629
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.371 0.629
M82 Osteoporosis in diseases classified elsewhere
0.000 0.373 0.627
I21.3 Acute transmural myocardial infarction of unspecified site
0.000 0.374 0.626
M80 Osteoporosis with pathological fracture
0.000 0.376 0.624
E89.4 Postprocedural ovarian failure
0.000 0.377 0.623
I25.4 Coronary artery aneurysm
0.000 0.378 0.622
E88 Other metabolic disorders
0.000 0.379 0.621
K74.5 Biliary cirrhosis, unspecified
0.000 0.380 0.620
K72 Hepatic failure, not elsewhere classified
0.000 0.380 0.620
L56 Other acute skin changes due to ultraviolet radiation
0.000 0.381 0.619
H33.4 Traction detachment of retina
0.000 0.381 0.619
D55-D59 Haemolytic anaemias
0.000 0.381 0.619
E73 Lactose intolerance
0.000 0.383 0.617
L20-L30 Dermatitis and eczema
0.000 0.387 0.613
E86 Volume depletion
0.000 0.387 0.613
E89.2 Postprocedural hypoparathyroidism
0.000 0.387 0.613
M65.43 Radial styloid tenosynovitis [de Quervain] (Forearm)
0.000 0.387 0.613
E89.0 Postprocedural hypothyroidism
0.000 0.387 0.613
H30.8 Other chorioretinal inflammations
0.000 0.387 0.612
H30.2 Posterior cyclitis
0.000 0.387 0.612
H30.1 Disseminated chorioretinal inflammation
0.000 0.387 0.612
H30.0 Focal chorioretinal inflammation
0.000 0.387 0.612
E03.8 Other specified hypothyroidism
0.000 0.389 0.610
D63 Anaemia in chronic diseases classified elsewhere
0.000 0.390 0.610
E16.1 Other hypoglycaemia
0.000 0.391 0.609
M25.66 Stiffness of joint, not elsewhere classified (Lower leg)
0.000 0.392 0.608
M34.2 Systemic sclerosis induced by drugs and chemicals
0.000 0.394 0.606
M65.8 Other synovitis and tenosynovitis
0.000 0.394 0.606
M80.9 Unspecified osteoporosis with pathological fracture
0.000 0.394 0.606
M06.40 Inflammatory polyarthropathy (Multiple sites)
0.000 0.394 0.606
M06.07 Seronegative rheumatoid arthritis (Ankle and foot)
0.000 0.395 0.605
I15.8 Other secondary hypertension
0.000 0.396 0.604
I15.2 Hypertension secondary to endocrine disorders
0.000 0.396 0.604
I15.0 Renovascular hypertension
0.000 0.396 0.604
M00-M03 Infectious arthropathies
0.000 0.396 0.604
I24.1 Dressler's syndrome
0.000 0.399 0.601
H40-H42 Glaucoma
0.000 0.399 0.601
I83 Varicose veins of lower extremities
0.600 0.399 0.000
M24 Other specific joint derangements
0.000 0.401 0.599
H35.1 Retinopathy of prematurity
0.000 0.405 0.595
M82.1 Osteoporosis in endocrine disorders
0.000 0.406 0.594
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.407 0.593
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.407 0.593
E89.5 Postprocedural testicular hypofunction
0.000 0.407 0.593
E89.1 Postprocedural hypoinsulinaemia
0.000 0.407 0.593
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system
0.009 0.407 0.584
G90-G99 Other disorders of the nervous system
0.010 0.408 0.582
H35.6 Retinal haemorrhage
0.000 0.411 0.588
K73 Chronic hepatitis, not elsewhere classified
0.000 0.411 0.588
E03.1 Congenital hypothyroidism without goitre
0.000 0.412 0.588
M35.8 Other specified systemic involvement of connective tissue
0.000 0.413 0.587
M25.40 Effusion of joint (Multiple sites)
0.000 0.414 0.586
M65.44 Radial styloid tenosynovitis [de Quervain] (Hand)
0.000 0.414 0.586
M32 Systemic lupus erythematosus
0.000 0.415 0.585
M34.0 Progressive systemic sclerosis
0.000 0.415 0.584
M34.9 Systemic sclerosis, unspecified
0.000 0.417 0.583
L40.3 Pustulosis palmaris et plantaris
0.000 0.424 0.576
M91-M94 Chondropathies
0.000 0.424 0.576
I21.0 Acute transmural myocardial infarction of anterior wall
0.000 0.425 0.575
I07 Rheumatic tricuspid valve diseases
0.000 0.425 0.575
H20.2 Lens-induced iridocyclitis
0.000 0.430 0.570
M80.90 Unspecified osteoporosis with pathological fracture (Multiple sites)
0.000 0.430 0.570
L28 Lichen simplex chronicus and prurigo
0.000 0.431 0.569
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.431 0.568
M12.3 Palindromic rheumatism
0.000 0.432 0.567
H15.1 Episcleritis
0.000 0.433 0.567
H35.7 Separation of retinal layers
0.000 0.433 0.567
H20.1 Chronic iridocyclitis
0.000 0.434 0.566
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.435 0.565
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.435 0.565
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.435 0.565
E74.2 Disorders of galactose metabolism
0.000 0.435 0.565
E74.1 Disorders of fructose metabolism
0.000 0.435 0.565
E74.0 Glycogen storage disease
0.000 0.435 0.565
M60-M63 Disorders of muscles
0.000 0.436 0.564
K72.9 Hepatic failure, unspecified
0.000 0.436 0.564
M80.98 Unspecified osteoporosis with pathological fracture (Other)
0.000 0.437 0.563
G91 Hydrocephalus
0.004 0.438 0.558
L50-L54 Urticaria and erythema
0.000 0.439 0.561
M65.84 Other synovitis and tenosynovitis (Hand)
0.000 0.440 0.560
M49.5 Collapsed vertebra in diseases classified elsewhere
0.000 0.440 0.560
E50-E64 Other nutritional deficiencies
0.000 0.440 0.560
H15.8 Other disorders of sclera
0.000 0.442 0.558
M11 Other crystal arthropathies
0.000 0.443 0.557
M34.8 Other forms of systemic sclerosis
0.000 0.443 0.557
M06.06 Seronegative rheumatoid arthritis (Lower leg)
0.000 0.448 0.552
D61.1 Drug-induced aplastic anaemia
0.000 0.449 0.551
G91.9 Hydrocephalus, unspecified
0.000 0.449 0.551
M13 Other arthritis
0.000 0.449 0.551
I09.9 Rheumatic heart disease, unspecified
0.000 0.449 0.551
M82.11 Osteoporosis in endocrine disorders (Shoulder region)
0.000 0.451 0.549
G72 Other myopathies
0.005 0.452 0.543
D51 Vitamin B12 deficiency anaemia
0.000 0.453 0.547
K75.9 Inflammatory liver disease, unspecified
0.000 0.455 0.545
M25.3 Other instability of joint
0.000 0.455 0.545
H21.0 Hyphaema
0.000 0.457 0.543
I08.3 Combined disorders of mitral, aortic and tricuspid valves
0.000 0.457 0.543
M14.5 Arthropathies in other endocrine, nutritional and metabolic disorders
0.000 0.458 0.542
M14.4 Arthropathy in amyloidosis
0.000 0.458 0.542
M14.3 Lipoid dermatoarthritis
0.000 0.458 0.542
M14.1 Crystal arthropathy in other metabolic disorders
0.000 0.458 0.542
M14.0 Gouty arthropathy due to enzyme defects and other inherited disorders
0.000 0.458 0.542
M30.0 Polyarteritis nodosa
0.000 0.459 0.541
K90.3 Pancreatic steatorrhoea
0.000 0.460 0.539
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.460 0.539
K90.1 Tropical sprue
0.000 0.460 0.539
I83.0 Varicose veins of lower extremities with ulcer
0.539 0.460 0.000
D64.8 Other specified anaemias
0.000 0.463 0.537
I08.0 Disorders of both mitral and aortic valves
0.000 0.464 0.536
M68 Disorders of synovium and tendon in diseases classified elsewhere
0.000 0.464 0.536
H35.5 Hereditary retinal dystrophy
0.000 0.466 0.533
M25.47 Effusion of joint (Ankle and foot)
0.000 0.466 0.533
L28.0 Lichen simplex chronicus
0.000 0.467 0.533
M49.8 Spondylopathy in other diseases classified elsewhere
0.000 0.467 0.532
M49.4 Neuropathic spondylopathy
0.000 0.467 0.532
M49.3 Spondylopathy in other infectious and parasitic diseases classified elsewhere
0.000 0.467 0.532
M49.2 Enterobacterial spondylitis
0.000 0.467 0.532
M49.1 Brucella spondylitis
0.000 0.467 0.532
M49.0 Tuberculosis of spine
0.000 0.467 0.532
H59 Postprocedural disorders of eye and adnexa, not elsewhere classified
0.000 0.469 0.531
H19.1 Herpesviral keratitis and keratoconjunctivitis
0.000 0.469 0.531
I11 Hypertensive heart disease
0.000 0.471 0.529
G70 Myasthenia gravis and other myoneural disorders
0.007 0.473 0.520
L56.8 Other specified acute skin changes due to ultraviolet radiation
0.000 0.473 0.527
I00 Rheumatic fever without mention of heart involvement
0.000 0.473 0.526
M25.43 Effusion of joint (Forearm)
0.000 0.475 0.525
M35.0 Sicca syndrome [Sjogren]
0.000 0.475 0.525
E80.6 Other disorders of bilirubin metabolism
0.000 0.476 0.524
H17 Corneal scars and opacities
0.000 0.477 0.523
G71 Primary disorders of muscles
0.008 0.478 0.515
E80.2 Other porphyria
0.000 0.478 0.522
K75.3 Granulomatous hepatitis, not elsewhere classified
0.000 0.479 0.521
M12.8 Other specific arthropathies, not elsewhere classified
0.000 0.479 0.521
M12.5 Traumatic arthropathy
0.000 0.479 0.521
M12.4 Intermittent hydrarthrosis
0.000 0.479 0.521
M12.1 Kaschin-Beck disease
0.000 0.479 0.521
M12.0 Chronic postrheumatic arthropathy [Jaccoud]
0.000 0.479 0.521
M65.1 Other infective (teno)synovitis
0.000 0.479 0.520

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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