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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs1476016
log Bayes Factor = 53.3483
Chromosome 6   position 28,922,719  (GRCh37) Explore rs1476016 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E83.1 Disorders of iron metabolism
1.000 0.000 0.000
K90.0 Coeliac disease
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
E10.9 Without complications
0.000 0.001 0.999
E05.9 Thyrotoxicosis, unspecified
0.000 0.001 0.999
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.002 0.998
E16.2 Hypoglycaemia, unspecified
0.000 0.003 0.997
E10-E14 Diabetes mellitus
0.000 0.003 0.997
E16 Other disorders of pancreatic internal secretion
0.000 0.004 0.996
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.004 0.996
E10.3 With ophthalmic complications
0.000 0.004 0.996
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.004 0.996
E00-E07 Disorders of thyroid gland
0.000 0.007 0.993
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.045 0.955
E10.2 With renal complications
0.000 0.055 0.945
E10.1 With ketoacidosis
0.000 0.084 0.916
E10.4 With neurological complications
0.000 0.099 0.901
E05.8 Other thyrotoxicosis
0.000 0.186 0.814
I83.9 Varicose veins of lower extremities without ulcer or inflammation
0.813 0.187 0.000
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.209 0.791
E13 Other specified diabetes mellitus
0.000 0.210 0.790
E16.1 Other hypoglycaemia
0.000 0.221 0.779
E10.7 With multiple complications
0.000 0.251 0.749
E10.0 With coma
0.000 0.278 0.722
E05.5 Thyroid crisis or storm
0.000 0.285 0.715
E05.4 Thyrotoxicosis factitia
0.000 0.285 0.715
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.285 0.715
E12 Malnutrition-related diabetes mellitus
0.000 0.285 0.715
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.285 0.714
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.285 0.714
E16.4 Abnormal secretion of gastrin
0.000 0.285 0.714
E16.3 Increased secretion of glucagon
0.000 0.285 0.714
E15 Nondiabetic hypoglycaemic coma
0.000 0.286 0.714
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.288 0.712
E00 Congenital iodine-deficiency syndrome
0.000 0.288 0.712
E14 Unspecified diabetes mellitus
0.000 0.320 0.680
E10.5 With peripheral circulatory complications
0.000 0.324 0.676
E40-E46 Malnutrition
0.000 0.325 0.675
E10.6 With other specified complications
0.000 0.331 0.669
E13.9 Without complications
0.000 0.361 0.639
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.363 0.637
E06 Thyroiditis
0.000 0.412 0.588
E07 Other disorders of thyroid
0.000 0.413 0.587
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.426 0.574
E13.3 With ophthalmic complications
0.000 0.429 0.571
E14.3 With ophthalmic complications
0.000 0.432 0.568
E13.8 With unspecified complications
0.000 0.433 0.566
E13.7 With multiple complications
0.000 0.433 0.566
E13.6 With other specified complications
0.000 0.433 0.566
E13.5 With peripheral circulatory complications
0.000 0.433 0.566
E13.4 With neurological complications
0.000 0.433 0.566
E13.2 With renal complications
0.000 0.433 0.566
E13.1 With ketoacidosis
0.000 0.433 0.566
E13.0 With coma
0.000 0.433 0.566
E14.1 With ketoacidosis
0.000 0.451 0.549
E14.6 With other specified complications
0.000 0.483 0.517
E12.9 Without complications
0.000 0.487 0.512
E12.8 With unspecified complications
0.000 0.487 0.512
E12.7 With multiple complications
0.000 0.487 0.512
E12.6 With other specified complications
0.000 0.487 0.512
E12.5 With peripheral circulatory complications
0.000 0.487 0.512
E12.4 With neurological complications
0.000 0.487 0.512
E12.3 With ophthalmic complications
0.000 0.487 0.512
E12.2 With renal complications
0.000 0.487 0.512
E12.1 With ketoacidosis
0.000 0.487 0.512
E12.0 With coma
0.000 0.487 0.512
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.489 0.511
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.489 0.511
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.489 0.511
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.489 0.511
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.489 0.511
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.489 0.511
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.489 0.511
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.489 0.511
E10.8 With unspecified complications
0.000 0.491 0.509
E14.4 With neurological complications
0.000 0.493 0.507
E14.8 With unspecified complications
0.000 0.506 0.494
E14.7 With multiple complications
0.000 0.512 0.488
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.516 0.484
E45 Retarded development following protein-energy malnutrition
0.000 0.516 0.484
E43 Unspecified severe protein-energy malnutrition
0.000 0.516 0.484
E42 Marasmic kwashiorkor
0.000 0.516 0.484
E41 Nutritional marasmus
0.000 0.516 0.484
E40 Kwashiorkor
0.000 0.516 0.484
E06.9 Thyroiditis, unspecified
0.000 0.524 0.476
E14.2 Withrenal complications
0.000 0.534 0.466
E14.5 With peripheral circulatory complications
0.000 0.539 0.461
E14.0 With coma
0.000 0.543 0.457
E07.8 Other specified disorders of thyroid
0.000 0.548 0.452
E46 Unspecified protein-energy malnutrition
0.000 0.555 0.445
E06.1 Subacute thyroiditis
0.000 0.558 0.442
E03 Other hypothyroidism
0.000 0.558 0.442
E06.4 Drug-induced thyroiditis
0.000 0.578 0.421
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.578 0.421
E06.0 Acute thyroiditis
0.000 0.578 0.421
E07.1 Dyshormogenetic goitre
0.000 0.579 0.421
E07.0 Hypersecretion of calcitonin
0.000 0.579 0.421
K90 Intestinal malabsorption
0.000 0.590 0.410
E06.5 Other chronic thyroiditis
0.000 0.595 0.404
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.001 0.613 0.387
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.650 0.350
E44.1 Mild protein-energy malnutrition
0.000 0.653 0.347
E44.0 Moderate protein-energy malnutrition
0.000 0.653 0.347
E65-E68 Obesity and other hyperalimentation
0.000 0.661 0.339
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.669 0.331
E11 Non-insulin-dependent diabetes mellitus
0.000 0.674 0.326
E50-E64 Other nutritional deficiencies
0.000 0.676 0.324
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.683 0.317
E03.5 Myxoedema coma
0.000 0.683 0.317
E03.4 Atrophy of thyroid (acquired)
0.000 0.683 0.317
E03.3 Postinfectious hypothyroidism
0.000 0.683 0.317
E03.1 Congenital hypothyroidism without goitre
0.000 0.695 0.305
E11.6 With other specified complications
0.000 0.703 0.297
K90.3 Pancreatic steatorrhoea
0.000 0.706 0.294
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.706 0.294
K90.1 Tropical sprue
0.000 0.706 0.294
K90.8 Other intestinal malabsorption
0.000 0.719 0.281
E11.1 With ketoacidosis
0.000 0.719 0.281
E11.0 With coma
0.000 0.729 0.271
E03.8 Other specified hypothyroidism
0.000 0.730 0.270
E11.2 With renal complications
0.000 0.754 0.246
E67 Other hyperalimentation
0.000 0.757 0.243
E68 Sequelae of hyperalimentation
0.000 0.757 0.243
E54 Ascorbic acid deficiency
0.000 0.764 0.236
E11.7 With multiple complications
0.000 0.766 0.234
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.768 0.232
E63 Other nutritional deficiencies
0.000 0.768 0.232
E50 Vitamin A deficiency
0.000 0.768 0.232
E60 Dietary zinc deficiency
0.000 0.768 0.232
E59 Dietary selenium deficiency
0.000 0.768 0.232
E52 Niacin deficiency [pellagra]
0.000 0.768 0.232
E51 Thiamine deficiency
0.000 0.769 0.231
E07.9 Disorder of thyroid, unspecified
0.000 0.770 0.230
M45.X9 Ankylosing spondylitis (Site unspecified)
0.221 0.779 0.000
E56 Other vitamin deficiencies
0.000 0.781 0.219
E55 Vitamin D deficiency
0.000 0.793 0.207
E58 Dietary calcium deficiency
0.000 0.798 0.202
E65 Localised adiposity
0.000 0.807 0.193
E11.8 With unspecified complications
0.000 0.807 0.193
K90.9 Intestinal malabsorption, unspecified
0.000 0.808 0.192
E20-E35 Disorders of other endocrine glands
0.000 0.812 0.188
E61 Deficiency of other nutrient elements
0.000 0.815 0.184
I83 Varicose veins of lower extremities
0.176 0.824 0.000
E67.8 Other specified hyperalimentation
0.000 0.825 0.174
E67.3 Hypervitaminosis D
0.000 0.825 0.174
E67.2 Megavitamin-B6 syndrome
0.000 0.825 0.174
E67.1 Hypercarotenaemia
0.000 0.825 0.174
E67.0 Hypervitaminosis A
0.000 0.825 0.174
E24 Cushing's syndrome
0.000 0.829 0.171
E50.9 Vitamin A deficiency, unspecified
0.000 0.833 0.167
E50.8 Other manifestations of vitamin A deficiency
0.000 0.833 0.167
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.833 0.167
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.833 0.167
E50.5 Vitamin A deficiency with night blindness
0.000 0.833 0.167
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.833 0.167
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.833 0.167
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.833 0.167
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.833 0.167
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.833 0.167
E63.9 Nutritional deficiency, unspecified
0.000 0.833 0.167
E63.8 Other specified nutritional deficiencies
0.000 0.833 0.167
E63.1 Imbalance of constituents of food intake
0.000 0.833 0.167
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.833 0.167
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.833 0.167
E64.8 Sequelae of other nutritional deficiencies
0.000 0.833 0.167
E64.3 Sequelae of rickets
0.000 0.833 0.167
E64.2 Sequelae of vitamin C deficiency
0.000 0.833 0.167
E64.1 Sequelae of vitamin A deficiency
0.000 0.833 0.167
E64.0 Sequelae of protein-energy malnutrition
0.000 0.833 0.167
E51.9 Thiamine deficiency, unspecified
0.000 0.834 0.166
E51.8 Other manifestations of thiamine deficiency
0.000 0.834 0.166
E51.1 Beriberi
0.000 0.834 0.166
E51.2 Wernicke's encephalopathy
0.000 0.836 0.164
E83 Disorders of mineral metabolism
0.150 0.836 0.014
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.842 0.158
E56.9 Vitamin deficiency, unspecified
0.000 0.842 0.157
E56.8 Deficiency of other vitamins
0.000 0.842 0.157
E56.0 Deficiency of vitamin E
0.000 0.842 0.157
E53 Deficiency of other B group vitamins
0.000 0.844 0.156
E14.9 Without complications
0.000 0.844 0.156
E21.3 Hyperparathyroidism, unspecified
0.000 0.849 0.151
E55.0 Rickets, active
0.000 0.851 0.149
E11.5 With peripheral circulatory complications
0.000 0.851 0.149
E24.9 Cushing's syndrome, unspecified
0.000 0.853 0.147
E03.9 Hypothyroidism, unspecified
0.000 0.855 0.145
E56.1 Deficiency of vitamin K
0.000 0.855 0.144
E06.3 Autoimmune thyroiditis
0.001 0.858 0.142
E24.0 Pituitary-dependent Cushing's disease
0.000 0.858 0.142
E20 Hypoparathyroidism
0.000 0.859 0.141
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.865 0.135
E32 Diseases of thymus
0.000 0.865 0.135
E30 Disorders of puberty, not elsewhere classified
0.000 0.865 0.135
E25 Adrenogenital disorders
0.000 0.865 0.135
E28 Ovarian dysfunction
0.000 0.867 0.133
E31 Polyglandular dysfunction
0.000 0.867 0.133
E61.9 Deficiency of nutrient element, unspecified
0.000 0.867 0.132
E61.8 Deficiency of other specified nutrient elements
0.000 0.867 0.132
E61.7 Deficiency of multiple nutrient elements
0.000 0.867 0.132
E61.6 Vanadium deficiency
0.000 0.867 0.132
E61.5 Molybdenum deficiency
0.000 0.867 0.132
E61.4 Chromium deficiency
0.000 0.867 0.132
E61.3 Manganese deficiency
0.000 0.867 0.132
E61.0 Copper deficiency
0.000 0.867 0.132
E83.3 Disorders of phosphorus metabolism
0.125 0.871 0.004
E24.2 Drug-induced Cushing's syndrome
0.000 0.871 0.129
E55.9 Vitamin D deficiency, unspecified
0.000 0.876 0.124
I83.0 Varicose veins of lower extremities with ulcer
0.124 0.876 0.000
E24.8 Other Cushing's syndrome
0.000 0.877 0.123
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.877 0.123
E24.3 Ectopic ACTH syndrome
0.000 0.877 0.123
E24.1 Nelson's syndrome
0.000 0.877 0.123
E83.8 Other disorders of mineral metabolism
0.107 0.882 0.010
E83.2 Disorders of zinc metabolism
0.107 0.882 0.010
E83.0 Disorders of copper metabolism
0.107 0.882 0.010
E83.9 Disorder of mineral metabolism, unspecified
0.107 0.883 0.010
E61.2 Magnesium deficiency
0.000 0.883 0.117
E29 Testicular dysfunction
0.000 0.883 0.117
C19 Malignant neoplasm of rectosigmoid junction
0.000 0.884 0.116
E53.9 Vitamin B deficiency, unspecified
0.000 0.885 0.115
I83.2 Varicose veins of lower extremities with both ulcer and inflammation
0.114 0.885 0.000
E21.2 Other hyperparathyroidism
0.000 0.886 0.114
E21.4 Other specified disorders of parathyroid gland
0.000 0.886 0.114
E53.1 Pyridoxine deficiency
0.000 0.888 0.112
E53.0 Riboflavin deficiency
0.000 0.888 0.112
M45 Ankylosing spondylitis
0.112 0.888 0.000
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.889 0.111
E61.1 Iron deficiency
0.000 0.892 0.107
E20.9 Hypoparathyroidism, unspecified
0.000 0.893 0.107
E34 Other endocrine disorders
0.000 0.897 0.103
E20.8 Other hypoparathyroidism
0.000 0.898 0.101
E20.1 Pseudohypoparathyroidism
0.000 0.898 0.101
E20.0 Idiopathic hypoparathyroidism
0.000 0.898 0.101
E28.2 Polycystic ovarian syndrome
0.000 0.902 0.098
E30.9 Disorder of puberty, unspecified
0.000 0.903 0.097
E30.8 Other disorders of puberty
0.000 0.903 0.097
E30.1 Precocious puberty
0.000 0.903 0.097
E30.0 Delayed puberty
0.000 0.903 0.097
E32.9 Disease of thymus, unspecified
0.000 0.903 0.097
E32.8 Other diseases of thymus
0.000 0.903 0.097
E32.1 Abscess of thymus
0.000 0.903 0.097
E32.0 Persistent hyperplasia of thymus
0.000 0.903 0.097
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.903 0.097
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.903 0.097
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.903 0.097
E25.9 Adrenogenital disorder, unspecified
0.000 0.903 0.097
E25.8 Other adrenogenital disorders
0.000 0.903 0.097
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.904 0.096
E28.9 Ovarian dysfunction, unspecified
0.000 0.904 0.095
E28.8 Other ovarian dysfunction
0.000 0.904 0.095
E28.1 Androgen excess
0.000 0.904 0.095
E28.0 Oestrogen excess
0.000 0.904 0.095
E31.9 Polyglandular dysfunction, unspecified
0.000 0.904 0.095
E31.8 Other polyglandular dysfunction
0.000 0.904 0.095
E31.1 Polyglandular hyperfunction
0.000 0.904 0.095
E11.3 With ophthalmic complications
0.000 0.907 0.093
E31.0 Autoimmune polyglandular failure
0.000 0.907 0.093
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.907 0.092
E28.3 Primary ovarian failure
0.000 0.910 0.090
E26 Hyperaldosteronism
0.000 0.911 0.088
M45.X2 Ankylosing spondylitis (Cervical region)
0.089 0.911 0.000
M45.X6 Ankylosing spondylitis (Lumbar region)
0.086 0.914 0.000
E29.9 Testicular dysfunction, unspecified
0.000 0.915 0.085
E21.0 Primary hyperparathyroidism
0.000 0.916 0.084
E29.8 Other testicular dysfunction
0.000 0.916 0.084
E29.0 Testicular hyperfunction
0.000 0.916 0.084
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)
0.080 0.920 0.000
M45.X7 Ankylosing spondylitis (Lumbosacral region)
0.080 0.920 0.000
M45.X5 Ankylosing spondylitis (Thoracolumbar region)
0.080 0.920 0.000
M45.X4 Ankylosing spondylitis (Thoracic region)
0.080 0.920 0.000
M45.X3 Ankylosing spondylitis (Cervicothoracic region)
0.080 0.920 0.000
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)
0.080 0.920 0.000
E22 Hyperfunction of pituitary gland
0.000 0.924 0.076
E34.3 Short stature, not elsewhere classified
0.000 0.925 0.075
E34.5 Androgen resistance syndrome
0.000 0.926 0.074
E34.4 Constitutional tall stature
0.000 0.926 0.074
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.926 0.074
E34.1 Other hypersecretion of intestinal hormones
0.000 0.926 0.074
E11.4 With neurological complications
0.000 0.926 0.074
E70-E90 Metabolic disorders
0.002 0.928 0.070
E23 Hypofunction and other disorders of pituitary gland
0.000 0.929 0.070
E34.8 Other specified endocrine disorders
0.000 0.931 0.069
E34.9 Endocrine disorder, unspecified
0.000 0.932 0.068
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.933 0.067
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.066 0.934 0.000
E78.2 Mixed hyperlipidaemia
0.000 0.934 0.066
C15 Malignant neoplasm of oesophagus
0.000 0.935 0.065
E26.8 Other hyperaldosteronism
0.000 0.936 0.063
E26.1 Secondary hyperaldosteronism
0.000 0.936 0.063
C15-C26 Malignant neoplasms of digestive organs
0.000 0.937 0.063
E29.1 Testicular hypofunction
0.000 0.937 0.063
I83.1 Varicose veins of lower extremities with inflammation
0.063 0.937 0.000
C20 Malignant neoplasm of rectum
0.000 0.938 0.062
E23.7 Disorder of pituitary gland, unspecified
0.000 0.939 0.061
C15.4 Middle third of oesophagus
0.000 0.941 0.059
E78.1 Pure hyperglyceridaemia
0.000 0.941 0.059
E83.4 Disorders of magnesium metabolism
0.053 0.941 0.006
C15.5 Lower third of oesophagus
0.000 0.941 0.059
E34.0 Carcinoid syndrome
0.000 0.942 0.058
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.001 0.944 0.055
E26.9 Hyperaldosteronism, unspecified
0.001 0.944 0.056
E74 Other disorders of carbohydrate metabolism
0.001 0.945 0.054
E22.8 Other hyperfunction of pituitary gland
0.000 0.945 0.055
E88 Other metabolic disorders
0.001 0.945 0.054
C15.9 Oesophagus, unspecified
0.000 0.946 0.054
E78.6 Lipoprotein deficiency
0.000 0.946 0.054
E78.5 Hyperlipidaemia, unspecified
0.000 0.947 0.053
E22.1 Hyperprolactinaemia
0.000 0.948 0.052
E77 Disorders of glycoprotein metabolism
0.001 0.948 0.051
E76 Disorders of glycosaminoglycan metabolism
0.001 0.948 0.051
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.001 0.948 0.051
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.001 0.948 0.051
C25 Malignant neoplasm of pancreas
0.000 0.948 0.052
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.948 0.051
E73 Lactose intolerance
0.001 0.949 0.050
E78.3 Hyperchylomicronaemia
0.000 0.949 0.051
E84 Cystic fibrosis
0.001 0.949 0.050
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.949 0.051
E23.1 Drug-induced hypopituitarism
0.000 0.949 0.051
C15.0 Cervical part of oesophagus
0.000 0.950 0.050
E70 Disorders of aromatic amino-acid metabolism
0.001 0.951 0.048
C15.3 Upper third of oesophagus
0.000 0.951 0.049
E79 Disorders of purine and pyrimidine metabolism
0.001 0.951 0.047
E85 Amyloidosis
0.001 0.952 0.047
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.952 0.047
E72 Other disorders of amino-acid metabolism
0.001 0.953 0.046
C15.1 Thoracic part of oesophagus
0.000 0.953 0.047
C15.8 Overlapping lesion of oesophagus
0.000 0.953 0.047
C15.2 Abdominal part of oesophagus
0.000 0.953 0.047
C17 Malignant neoplasm of small intestine
0.000 0.953 0.046
E88.9 Metabolic disorder, unspecified
0.000 0.954 0.046
E04 Other non-toxic goitre
0.001 0.955 0.044
E75.5 Other lipid storage disorders
0.001 0.955 0.044
C17.0 Duodenum
0.000 0.955 0.045
C24 Malignant neoplasm of other and unspecified parts of biliary tract
0.000 0.956 0.044
E74.3 Other disorders of intestinal carbohydrate absorption
0.001 0.956 0.043
E78.4 Other hyperlipidaemia
0.000 0.957 0.043
E88.2 Lipomatosis, not elsewhere classified
0.000 0.957 0.043
C25.3 Pancreatic duct
0.000 0.957 0.043
C25.2 Tail of pancreas
0.000 0.957 0.043
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.957 0.043
C25.1 Body of pancreas
0.000 0.958 0.042
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.958 0.042
I77 Other disorders of arteries and arterioles
0.000 0.959 0.041
E75.2 Other sphingolipidosis
0.001 0.959 0.040
I73.9 Peripheral vascular disease, unspecified
0.000 0.959 0.041
I73 Other peripheral vascular diseases
0.000 0.959 0.041
E75.6 Lipid storage disorder, unspecified
0.001 0.959 0.040
E75.4 Neuronal ceroid lipofuscinosis
0.001 0.959 0.040
E75.3 Sphingolipidosis, unspecified
0.001 0.959 0.040
E75.1 Other gangliosidosis
0.001 0.959 0.040
E75.0 GM2 gangliosidosis
0.001 0.959 0.040
C25.8 Overlapping lesion of pancreas
0.000 0.959 0.040
C25.4 Endocrine pancreas
0.000 0.960 0.040
I70-I79 Diseases of arteries, arterioles and capillaries
0.000 0.960 0.040
E74.9 Disorder of carbohydrate metabolism, unspecified
0.001 0.960 0.039
E74.8 Other specified disorders of carbohydrate metabolism
0.001 0.960 0.039
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.001 0.960 0.039
E74.2 Disorders of galactose metabolism
0.001 0.960 0.039
E74.1 Disorders of fructose metabolism
0.001 0.960 0.039
I77.6 Arteritis, unspecified
0.000 0.961 0.039
C24.0 Extrahepatic bile duct
0.000 0.961 0.039
C21 Malignant neoplasm of anus and anal canal
0.000 0.961 0.039
E74.0 Glycogen storage disease
0.001 0.961 0.038
I77.9 Disorder of arteries and arterioles, unspecified
0.000 0.961 0.039
E85.4 Organ-limited amyloidosis
0.001 0.962 0.038
I74 Arterial embolism and thrombosis
0.000 0.962 0.038
E84.0 Cystic fibrosis with pulmonary manifestations
0.001 0.962 0.037
E71.3 Disorders of fatty-acid metabolism
0.001 0.962 0.036
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.001 0.962 0.036
E71.1 Other disorders of branched-chain amino-acid metabolism
0.001 0.962 0.036
E71.0 Maple-syrup-urine disease
0.001 0.962 0.036
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.001 0.962 0.036
E76.8 Other disorders of glucosaminoglycan metabolism
0.001 0.962 0.036
E76.3 Mucopolysaccharidosis, unspecified
0.001 0.962 0.036
E76.2 Other mucopolysaccharidoses
0.001 0.962 0.036
E76.1 Mucopolysaccharidosis, type II
0.001 0.962 0.036
E76.0 Mucopolysaccharidosis, type I
0.001 0.962 0.036
E77.9 Disorder of glycoprotein metabolism, unspecified
0.001 0.962 0.036
E77.8 Other disorders of glycoprotein metabolism
0.001 0.962 0.036
E77.1 Defects in glycoprotein degradation
0.001 0.962 0.036
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.001 0.962 0.036
E88.8 Other specified metabolic disorders
0.001 0.963 0.037
E22.0 Acromegaly and pituitary gigantism
0.000 0.963 0.037
E73.8 Other lactose intolerance
0.001 0.963 0.036
E73.1 Secondary lactase deficiency
0.001 0.963 0.036
E73.0 Congenital lactase deficiency
0.001 0.963 0.036
E84.8 Cystic fibrosis with other manifestations
0.001 0.963 0.036
E84.1 Cystic fibrosis with intestinal manifestations
0.001 0.963 0.036
E73.9 Lactose intolerance, unspecified
0.001 0.964 0.036
I74.5 Embolism and thrombosis of iliac artery
0.000 0.964 0.036
I74.3 Embolism and thrombosis of arteries of the lower extremities
0.000 0.964 0.036
I72 Other aneurysm
0.000 0.964 0.036
I77.8 Other specified disorders of arteries and arterioles
0.000 0.964 0.036
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.001 0.964 0.035
E70.8 Other disorders of aromatic amino-acid metabolism
0.001 0.964 0.035
E70.2 Disorders of tyrosine metabolism
0.001 0.964 0.035
E70.1 Other hyperphenylalaninaemias
0.001 0.964 0.035
E70.0 Classical phenylketonuria
0.001 0.964 0.035
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.001 0.965 0.034
E79.8 Other disorders of purine and pyrimidine metabolism
0.001 0.965 0.034
E79.1 Lesch-Nyhan syndrome
0.001 0.965 0.034
E84.9 Cystic fibrosis, unspecified
0.001 0.965 0.034
E85.8 Other amyloidosis
0.001 0.965 0.034
E85.3 Secondary systemic amyloidosis
0.001 0.965 0.034
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.965 0.035
E85.2 Heredofamilial amyloidosis, unspecified
0.001 0.965 0.034
E85.1 Neuropathic heredofamilial amyloidosis
0.001 0.965 0.034
E85.0 Nonneuropathic heredofamilial amyloidosis
0.001 0.965 0.034
I73.0 Raynaud's syndrome
0.000 0.965 0.035
C25.9 Pancreas, unspecified
0.000 0.966 0.034
E72.9 Disorder of amino-acid metabolism, unspecified
0.001 0.966 0.033
E72.8 Other specified disorders of amino-acid metabolism
0.001 0.966 0.033
E72.5 Disorders of glycine metabolism
0.001 0.966 0.033
E72.4 Disorders of ornithine metabolism
0.001 0.966 0.033
E72.3 Disorders of lysine and hydroxylysine metabolism
0.001 0.966 0.033
E72.2 Disorders of urea cycle metabolism
0.001 0.966 0.033
E23.6 Other disorders of pituitary gland
0.000 0.966 0.034
E26.0 Primary hyperaldosteronism
0.001 0.966 0.033
C25.7 Other parts of pancreas
0.000 0.966 0.034
C17.8 Overlapping lesion of small intestine
0.000 0.966 0.033
C17.3 Meckel's diverticulum
0.000 0.966 0.033
E72.0 Disorders of amino-acid transport
0.001 0.967 0.032
E23.2 Diabetes insipidus
0.000 0.967 0.033
E70.3 Albinism
0.001 0.967 0.032
E88.3 Tumour lysis syndrome
0.001 0.967 0.032
E04.8 Other specified non-toxic goitre
0.001 0.967 0.032
I74.4 Embolism and thrombosis of arteries of extremities, unspecified
0.000 0.967 0.033
C24.8 Overlapping lesion of biliary tract
0.000 0.968 0.032
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.001 0.968 0.031
I73.8 Other specified peripheral vascular diseases
0.000 0.968 0.031
I77.3 Arterial fibromuscular dysplasia
0.000 0.969 0.031
I72.4 Aneurysm of artery of lower extremity
0.000 0.969 0.031
E78.8 Other disorders of lipoprotein metabolism
0.000 0.969 0.031
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.001 0.969 0.030
I70 Atherosclerosis
0.000 0.969 0.031
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.000 0.969 0.030
C21.8 Overlapping lesion of rectum, anus and anal canal
0.000 0.970 0.030
I77.1 Stricture of artery
0.000 0.970 0.030
C24.9 Biliary tract, unspecified
0.000 0.970 0.030
I77.2 Rupture of artery
0.000 0.970 0.030
I72.3 Aneurysm of iliac artery
0.000 0.970 0.030
C17.1 Jejunum
0.000 0.970 0.030
I77.5 Necrosis of artery
0.000 0.970 0.030
I77.4 Coeliac artery compression syndrome
0.000 0.970 0.030
E78.0 Pure hypercholesterolaemia
0.000 0.970 0.030
I74.2 Embolism and thrombosis of arteries of the upper extremities
0.000 0.971 0.029
E66 Obesity
0.000 0.971 0.029
C26 Malignant neoplasm of other and ill-defined digestive organs
0.000 0.971 0.028
E80 Disorders of porphyrin and bilirubin metabolism
0.001 0.972 0.027
C21.2 Cloacogenic zone
0.000 0.972 0.028
E53.8 Deficiency of other specified B group vitamins
0.000 0.972 0.028
I72.1 Aneurysm of artery of upper extremity
0.000 0.972 0.028
C23 Malignant neoplasm of gallbladder
0.000 0.972 0.028
E27 Other disorders of adrenal gland
0.000 0.972 0.027
I74.0 Embolism and thrombosis of abdominal aorta
0.000 0.972 0.027
I72.0 Aneurysm of carotid artery
0.000 0.973 0.027
I73.1 Thromboangiitis obliterans [Buerger]
0.000 0.973 0.027
Z72.0 Tobacco use
0.026 0.974 0.000
I72.6 Aneurysm and dissection of vertebral artery
0.000 0.974 0.026
I72.5 Aneurysm and dissection of other precerebral arteries
0.000 0.974 0.026
I72.9 Aneurysm of unspecified site
0.000 0.974 0.025
C22 Malignant neoplasm of liver and intrahepatic bile ducts
0.000 0.974 0.025
K90-K93 Other diseases of the digestive system
0.000 0.975 0.025
C21.0 Anus, unspecified
0.000 0.976 0.024
I72.2 Aneurysm of renal artery
0.000 0.976 0.024
R31 Unspecified haematuria
0.024 0.976 0.000
I70.2 Atherosclerosis of arteries of the extremities
0.000 0.976 0.024
I70.8 Atherosclerosis of other arteries
0.000 0.977 0.023
I70.1 Atherosclerosis of renal artery
0.000 0.977 0.023
I79.8 Other disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.000 0.977 0.023
E04.0 Non-toxic diffuse goitre
0.001 0.977 0.022
I72.8 Aneurysm of other specified arteries
0.000 0.977 0.023
C21.1 Anal canal
0.000 0.977 0.023
I79.2 Peripheral angiopathy in diseases classified elsewhere
0.000 0.977 0.023
M45-M49 Spondylopathies
0.023 0.977 0.000
I74.1 Embolism and thrombosis of other and unspecified parts of aorta
0.000 0.978 0.022
E85.9 Amyloidosis, unspecified
0.001 0.978 0.021
C17.9 Small intestine, unspecified
0.000 0.978 0.022
I80-I89 Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified
0.022 0.978 0.000
C17.2 Ileum
0.000 0.978 0.022
I79.1 Aortitis in diseases classified elsewhere
0.000 0.978 0.022
I79.0 Aneurysm of aorta in diseases classified elsewhere
0.000 0.978 0.022
E80.2 Other porphyria
0.001 0.978 0.021
I70.9 Generalised and unspecified atherosclerosis
0.000 0.978 0.021
E11.9 Without complications
0.000 0.979 0.021
E66.1 Drug-induced obesity
0.000 0.979 0.021
C26.8 Overlapping lesion of digestive system
0.000 0.979 0.020
C26.1 Spleen
0.000 0.979 0.020
I70.0 Atherosclerosis of aorta
0.000 0.979 0.021
E80.7 Disorder of bilirubin metabolism, unspecified
0.001 0.979 0.020
E80.5 Crigler-Najjar syndrome
0.001 0.979 0.020
E80.3 Defects of catalase and peroxydase
0.001 0.979 0.020
E80.0 Hereditary erythropoietic porphyria
0.001 0.979 0.020
E23.0 Hypopituitarism
0.000 0.980 0.020
I89 Other non-infective disorders of lymphatic vessels and lymph nodes
0.020 0.980 0.000
E27.5 Adrenomedullary hyperfunction
0.000 0.980 0.020
E27.0 Other adrenocortical overactivity
0.000 0.980 0.020
I70.21 Atherosclerosis of arteries of extremities (with gangrene)
0.000 0.981 0.019
I86 Varicose veins of other sites
0.019 0.981 0.000
E27.1 Primary adrenocortical insufficiency
0.000 0.981 0.019

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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