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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs1521
log Bayes Factor = 67.6085
Chromosome 6   position 31,350,704  (GRCh37) Explore rs1521 on Ensembl!
Variant rs1521 is listed in the   GWAS Catalog   ⇪

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.000 1.000
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
E10.9 Without complications
0.000 0.000 1.000
M06.9 Rheumatoid arthritis, unspecified
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
I20-I25 Ischaemic heart diseases
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.000 1.000
M45.X9 Ankylosing spondylitis (Site unspecified)
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.000 1.000
E03 Other hypothyroidism
0.000 0.000 1.000
E78.0 Pure hypercholesterolaemia
0.000 0.000 1.000
I25 Chronic ischaemic heart disease
0.000 0.000 1.000
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.000 1.000
E83.1 Disorders of iron metabolism
1.000 0.000 0.000
E11 Non-insulin-dependent diabetes mellitus
0.000 0.000 1.000
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.000 1.000
E14 Unspecified diabetes mellitus
0.000 0.000 1.000
M45 Ankylosing spondylitis
0.000 0.000 1.000
I25.1 Atherosclerotic heart disease
0.000 0.000 1.000
E11.9 Without complications
0.000 0.001 0.999
E14.9 Without complications
0.000 0.001 0.999
G35 Multiple sclerosis
0.999 0.001 0.000
M06 Other rheumatoid arthritis
0.000 0.001 0.999
I10-I15 Hypertensive diseases
0.000 0.001 0.999
Chapter IX Diseases of the circulatory system
0.000 0.002 0.998
E05.9 Thyrotoxicosis, unspecified
0.000 0.002 0.998
I10 Essential (primary) hypertension
0.000 0.002 0.998
M05-M14 Inflammatory polyarthropathies
0.000 0.003 0.997
E70-E90 Metabolic disorders
0.000 0.003 0.997
E10.1 With ketoacidosis
0.000 0.004 0.996
I21 Acute myocardial infarction
0.000 0.005 0.995
L40 Psoriasis
0.000 0.005 0.995
L40.5 Arthropathic psoriasis
0.000 0.006 0.994
I22 Subsequent myocardial infarction
0.000 0.007 0.993
I21.9 Acute myocardial infarction, unspecified
0.000 0.009 0.991
M45-M49 Spondylopathies
0.000 0.012 0.988
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.000 0.012 0.988
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.012 0.988
L40.9 Psoriasis, unspecified
0.000 0.013 0.987
L40-L45 Papulosquamous disorders
0.000 0.015 0.985
I22.1 Subsequent myocardial infarction of inferior wall
0.000 0.015 0.985
# Top node
0.000 0.019 0.981
I25.5 Ischaemic cardiomyopathy
0.000 0.021 0.979
M07 Psoriatic and enteropathic arthropathies
0.000 0.027 0.973
I12 Hypertensive renal disease
0.000 0.027 0.973
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.000 0.032 0.968
Chapter XII Diseases of the skin and subcutaneous tissue
0.000 0.033 0.967
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.000 0.035 0.965
M07.3 Other psoriatic arthropathies
0.000 0.041 0.959
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.000 0.042 0.958
E20-E35 Disorders of other endocrine glands
0.000 0.043 0.957
E10.4 With neurological complications
0.000 0.044 0.956
I12.9 Hypertensive renal disease without renal failure
0.000 0.045 0.955
M05 Seropositive rheumatoid arthritis
0.000 0.045 0.955
I21.2 Acute transmural myocardial infarction of other sites
0.000 0.052 0.948
E11.1 With ketoacidosis
0.000 0.060 0.940
M07.30 Other psoriatic arthropathies (Multiple sites)
0.000 0.064 0.936
M05.9 Seropositive rheumatoid arthritis, unspecified
0.000 0.066 0.934
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.069 0.931
M45.X2 Ankylosing spondylitis (Cervical region)
0.000 0.071 0.929
M06.3 Rheumatoid nodule
0.000 0.077 0.923
E78.2 Mixed hyperlipidaemia
0.000 0.094 0.906
I25.8 Other forms of chronic ischaemic heart disease
0.000 0.096 0.904
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.000 0.097 0.903
E06 Thyroiditis
0.000 0.100 0.900
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.101 0.899
I70-I79 Diseases of arteries, arterioles and capillaries
0.000 0.102 0.898
E10.2 With renal complications
0.000 0.108 0.892
M05.90 Seropositive rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.109 0.891
I24 Other acute ischaemic heart diseases
0.000 0.113 0.887
Chapter V Mental and behavioural disorders
0.000 0.114 0.886
F30-F39 Mood [affective] disorders
0.000 0.114 0.886
F31 Bipolar affective disorder
0.000 0.118 0.882
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.000 0.119 0.881
L43 Lichen planus
0.000 0.121 0.879
I70 Atherosclerosis
0.000 0.125 0.875
M07.36 Other psoriatic arthropathies (Lower leg)
0.000 0.128 0.872
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.128 0.872
E78.1 Pure hyperglyceridaemia
0.000 0.133 0.867
M05.99 Seropositive rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.137 0.863
F30 Manic episode
0.000 0.138 0.862
I70.2 Atherosclerosis of arteries of the extremities
0.000 0.139 0.861
L40.8 Other psoriasis
0.000 0.149 0.851
I70.20 Atherosclerosis of arteries of extremities (without gangrene)
0.000 0.156 0.844
E07 Other disorders of thyroid
0.000 0.157 0.843
E23 Hypofunction and other disorders of pituitary gland
0.000 0.158 0.842
I20 Angina pectoris
0.000 0.164 0.836
E28 Ovarian dysfunction
0.000 0.166 0.834
E78.8 Other disorders of lipoprotein metabolism
0.000 0.166 0.834
I25.2 Old myocardial infarction
0.000 0.167 0.833
E10.8 With unspecified complications
0.000 0.168 0.832
I23 Certain current complications following acute myocardial infarction
0.000 0.170 0.830
E10.5 With peripheral circulatory complications
0.000 0.171 0.829
I24.8 Other forms of acute ischaemic heart disease
0.000 0.174 0.826
E14.3 With ophthalmic complications
0.000 0.177 0.823
I22.8 Subsequent myocardial infarction of other sites
0.000 0.177 0.823
E11.0 With coma
0.000 0.177 0.823
I15 Secondary hypertension
0.000 0.178 0.822
Chapter VIII Diseases of the ear and mastoid process
0.000 0.179 0.821
E06.3 Autoimmune thyroiditis
0.000 0.183 0.817
E27 Other disorders of adrenal gland
0.000 0.184 0.816
F30.0 Hypomania
0.000 0.184 0.816
E78.6 Lipoprotein deficiency
0.000 0.185 0.815
E11.3 With ophthalmic complications
0.000 0.186 0.814
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.191 0.809
E74 Other disorders of carbohydrate metabolism
0.000 0.192 0.808
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.194 0.806
I22.9 Subsequent myocardial infarction of unspecified site
0.000 0.196 0.804
H60-H62 Diseases of external ear
0.000 0.197 0.803
F31.0 Bipolar affective disorder, current episode hypomanic
0.000 0.205 0.795
M06.32 Rheumatoid nodule (Upper arm)
0.000 0.207 0.793
E14.1 With ketoacidosis
0.000 0.208 0.792
F31.3 Bipolar affective disorder, current episode mild or moderate depression
0.000 0.211 0.789
F31.1 Bipolar affective disorder, current episode manic without psychotic symptoms
0.000 0.213 0.787
M70-M79 Other soft tissue disorders
0.000 0.220 0.780
I20.0 Unstable angina
0.000 0.222 0.778
L40.1 Generalised pustular psoriasis
0.000 0.222 0.777
H60 Otitis externa
0.000 0.223 0.777
E11.5 With peripheral circulatory complications
0.000 0.224 0.776
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.000 0.224 0.776
I21.4 Acute subendocardial myocardial infarction
0.000 0.224 0.776
E78.4 Other hyperlipidaemia
0.000 0.226 0.774
F80-F89 Disorders of psychological development
0.000 0.227 0.773
E85 Amyloidosis
0.000 0.227 0.772
E11.2 With renal complications
0.000 0.228 0.772
E10.0 With coma
0.000 0.228 0.772
M06.98 Rheumatoid arthritis, unspecified (Other)
0.000 0.229 0.771
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.230 0.770
M06.34 Rheumatoid nodule (Hand)
0.000 0.230 0.770
E21.3 Hyperparathyroidism, unspecified
0.000 0.230 0.770
E23.7 Disorder of pituitary gland, unspecified
0.000 0.232 0.768
M70 Soft tissue disorders related to use, overuse and pressure
0.000 0.234 0.766
M70.4 Prepatellar bursitis
0.000 0.242 0.758
E14.4 With neurological complications
0.000 0.245 0.755
M35 Other systemic involvement of connective tissue
0.000 0.246 0.754
M70.46 Prepatellar bursitis-Lower Leg
0.000 0.247 0.753
M49 Spondylopathies in diseases classified elsewhere
0.000 0.250 0.750
M35.3 Polymyalgia rheumatica
0.000 0.251 0.749
M20-M25 Other joint disorders
0.000 0.252 0.748
L43.8 Other lichen planus
0.000 0.252 0.748
E14.5 With peripheral circulatory complications
0.000 0.252 0.747
I73 Other peripheral vascular diseases
0.000 0.253 0.747
F30.9 Manic episode, unspecified
0.000 0.253 0.747
E27.1 Primary adrenocortical insufficiency
0.000 0.254 0.746
F31.6 Bipolar affective disorder, current episode mixed
0.000 0.258 0.742
E22 Hyperfunction of pituitary gland
0.000 0.258 0.742
F31.5 Bipolar affective disorder, current episode severe depression with psychotic symptoms
0.000 0.262 0.738
L43.9 Lichen planus, unspecified
0.000 0.265 0.735
M07.37 Other psoriatic arthropathies (Ankle and foot)
0.000 0.265 0.735
I74 Arterial embolism and thrombosis
0.000 0.266 0.734
M06.37 Rheumatoid nodule (Ankle and foot)
0.000 0.266 0.734
E79 Disorders of purine and pyrimidine metabolism
0.000 0.270 0.729
L42 Pityriasis rosea
0.000 0.271 0.729
E28.2 Polycystic ovarian syndrome
0.000 0.275 0.725
E84 Cystic fibrosis
0.000 0.281 0.719
H60.9 Otitis externa, unspecified
0.000 0.281 0.719
E10.7 With multiple complications
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
E03.5 Myxoedema coma
0.000 0.283 0.717
E03.4 Atrophy of thyroid (acquired)
0.000 0.283 0.717
E03.3 Postinfectious hypothyroidism
0.000 0.283 0.717
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.283 0.717
I25.6 Silent myocardial ischaemia
0.000 0.283 0.717
E05.5 Thyroid crisis or storm
0.000 0.283 0.717
E05.4 Thyrotoxicosis factitia
0.000 0.283 0.717
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.283 0.717
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.283 0.717
E11.7 With multiple complications
0.000 0.283 0.717
E78.3 Hyperchylomicronaemia
0.000 0.283 0.717
E14.8 With unspecified complications
0.000 0.283 0.717
E14.7 With multiple complications
0.000 0.283 0.717
E14.0 With coma
0.000 0.283 0.717
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)
0.000 0.283 0.717
M45.X7 Ankylosing spondylitis (Lumbosacral region)
0.000 0.283 0.717
M45.X6 Ankylosing spondylitis (Lumbar region)
0.000 0.283 0.717
M45.X5 Ankylosing spondylitis (Thoracolumbar region)
0.000 0.283 0.717
M45.X4 Ankylosing spondylitis (Thoracic region)
0.000 0.283 0.717
M45.X3 Ankylosing spondylitis (Cervicothoracic region)
0.000 0.283 0.717
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)
0.000 0.283 0.717
M06.8 Other specified rheumatoid arthritis
0.000 0.284 0.716
M06.2 Rheumatoid bursitis
0.000 0.284 0.716
M06.1 Adult-onset Still's disease
0.000 0.284 0.716
M09 Juvenile arthritis in diseases classified elsewhere
0.000 0.285 0.715
M08 Juvenile arthritis
0.000 0.285 0.715
E77 Disorders of glycoprotein metabolism
0.000 0.285 0.715
E76 Disorders of glycosaminoglycan metabolism
0.000 0.285 0.715
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.285 0.715
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.285 0.715
E74.3 Other disorders of intestinal carbohydrate absorption
0.000 0.285 0.715
I70.21 Atherosclerosis of arteries of extremities (with gangrene)
0.000 0.286 0.714
F31.9 Bipolar affective disorder, unspecified
0.000 0.286 0.714
I21.X Presumed acute myicardial infaction (unconfirmed)
0.000 0.287 0.713
L40.4 Guttate psoriasis
0.000 0.287 0.713
L40.2 Acrodermatitis continua
0.000 0.287 0.713
I20.9 Angina pectoris, unspecified
0.000 0.287 0.713
E14.6 With other specified complications
0.000 0.288 0.712
E07.9 Disorder of thyroid, unspecified
0.000 0.288 0.712
E70 Disorders of aromatic amino-acid metabolism
0.000 0.291 0.709
I15.9 Seconday hypertension, unspecified
0.000 0.292 0.708
I23.8 Other current complications following acute myocardial infarction
0.000 0.293 0.707
L44 Other papulosquamous disorders
0.000 0.293 0.706
L41 Parapsoriasis
0.000 0.293 0.706
L45 Papulosquamous disorders in diseases classified elsewhere
0.000 0.293 0.706
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.296 0.704
Chapter XVI Certain conditions originating in the perinatal period
0.000 0.296 0.703
G35-G37 Demyelinating diseases of the central nervous system
0.703 0.297 0.000
E27.9 Disorder of adrenal gland, unspecified
0.000 0.297 0.703
E73 Lactose intolerance
0.000 0.297 0.703
E10.6 With other specified complications
0.000 0.300 0.700
E23.6 Other disorders of pituitary gland
0.000 0.301 0.699
M07.5 Arthropathy in ulcerative colitis
0.000 0.302 0.698
M07.4 Arthropathy in Crohn's disease [regional enteritis]
0.000 0.302 0.698
M07.2 Psoriatic spondylitis
0.000 0.302 0.698
M07.1 Arthritis mutilans
0.000 0.302 0.698
M07.0 Distal interphalangeal psoriatic arthropathy
0.000 0.302 0.698
E29 Testicular dysfunction
0.000 0.305 0.695
I71 Aortic aneurysm and dissection
0.000 0.310 0.690
I79.2 Peripheral angiopathy in diseases classified elsewhere
0.000 0.312 0.688
M07.38 Other psoriatic arthropathies (Other)
0.000 0.312 0.688
M07.34 Other psoriatic arthropathies (Hand)
0.000 0.312 0.688
M07.33 Other psoriatic arthropathies (Forearm)
0.000 0.312 0.688
M07.32 Other psoriatic arthropathies (Upper arm)
0.000 0.312 0.688
M07.31 Other psoriatic arthropathies (Shoulder region)
0.000 0.312 0.688
M75 Shoulder lesions
0.000 0.313 0.687
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.314 0.686
E32 Diseases of thymus
0.000 0.314 0.686
E31 Polyglandular dysfunction
0.000 0.314 0.686
E30 Disorders of puberty, not elsewhere classified
0.000 0.314 0.686
E25 Adrenogenital disorders
0.000 0.314 0.686
M91-M94 Chondropathies
0.000 0.314 0.686
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.314 0.686
F34 Persistent mood [affective] disorders
0.000 0.315 0.685
M05.8 Other seropositive rheumatoid arthritis
0.000 0.315 0.685
M05.3 Rheumatoid arthritis with involvement of other organs and systems
0.000 0.315 0.685
M05.1 Rheumatoid lung disease
0.000 0.315 0.685
M05.0 Felty's syndrome
0.000 0.315 0.685
M46 Other inflammatory spondylopathies
0.000 0.316 0.684
H61 Other disorders of external ear
0.000 0.317 0.683
E06.9 Thyroiditis, unspecified
0.000 0.319 0.681
I05-I09 Chronic rheumatic heart diseases
0.000 0.321 0.679
M35.1 Other overlap syndromes
0.000 0.323 0.677
I12.0 Hypertensive renal disease with renal failure
0.000 0.324 0.676
I71.9 Aortic aneurysm of unspecified site, without mention of rupture
0.000 0.324 0.676
M34 Systemic sclerosis
0.000 0.325 0.675
F30.2 Mania with psychotic symptoms
0.000 0.329 0.671
M05.98 Seropositive rheumatoid arthritis, unspecified (Other)
0.000 0.331 0.669
M05.95 Seropositive rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.331 0.669
M05.94 Seropositive rheumatoid arthritis, unspecified (Hand)
0.000 0.331 0.669
M05.93 Seropositive rheumatoid arthritis, unspecified (Forearm)
0.000 0.331 0.669
M05.92 Seropositive rheumatoid arthritis, unspecified (Upper arm)
0.000 0.331 0.669
M05.91 Seropositive rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.331 0.669
E03.8 Other specified hypothyroidism
0.000 0.331 0.669
H60.3 Other infective otitis externa
0.000 0.331 0.669
M75.0 Adhesive capsulitis of shoulder
0.000 0.331 0.669
I74.3 Embolism and thrombosis of arteries of the lower extremities
0.000 0.332 0.668
M12 Other specific arthropathies
0.000 0.332 0.668
E16 Other disorders of pancreatic internal secretion
0.000 0.333 0.667
K90.0 Coeliac disease
0.000 0.333 0.667
M06.30 Rheumatoid nodule (Multiple sites)
0.000 0.333 0.667
E85.4 Organ-limited amyloidosis
0.000 0.333 0.667
E14.2 Withrenal complications
0.000 0.335 0.665
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.000 0.338 0.662
M06.39 Rheumatoid nodule (Site unspecified)
0.000 0.338 0.662
M06.38 Rheumatoid nodule (Other)
0.000 0.338 0.662
M06.36 Rheumatoid nodule (Lower leg)
0.000 0.338 0.662
M06.35 Rheumatoid nodule (Pelvic region and thigh)
0.000 0.338 0.662
M06.33 Rheumatoid nodule (Forearm)
0.000 0.338 0.662
M06.31 Rheumatoid nodule (Shoulder region)
0.000 0.338 0.662
G37 Other demyelinating diseases of central nervous system
0.650 0.350 0.000
L10-L14 Bullous disorders
0.000 0.350 0.650
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.352 0.648
I13 Hypertensive heart and renal disease
0.000 0.353 0.647
E28.3 Primary ovarian failure
0.000 0.354 0.646
E06.5 Other chronic thyroiditis
0.000 0.354 0.645
E06.4 Drug-induced thyroiditis
0.000 0.354 0.645
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.354 0.645
E06.1 Subacute thyroiditis
0.000 0.354 0.645
E06.0 Acute thyroiditis
0.000 0.354 0.645
E03.1 Congenital hypothyroidism without goitre
0.000 0.356 0.644
F80 Specific developmental disorders of speech and language
0.000 0.357 0.643
I00-I02 Acute rheumatic fever
0.000 0.358 0.642
E24 Cushing's syndrome
0.000 0.358 0.642
M07.6 Other enteropathic arthropathies
0.000 0.358 0.642
E26 Hyperaldosteronism
0.000 0.358 0.641
F31.7 Bipolar affective disorder, currently in remission
0.000 0.360 0.640
E40-E46 Malnutrition
0.000 0.361 0.639
M05.97 Seropositive rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.361 0.639
E07.8 Other specified disorders of thyroid
0.000 0.361 0.638
F90-F98 Behavioural and emotional disorders with onset usually occurring in childhood and adolescence
0.000 0.364 0.635
F38 Other mood [affective] disorders
0.000 0.365 0.635
M11 Other crystal arthropathies
0.000 0.365 0.635
F81 Specific developmental disorders of scholastic skills
0.000 0.365 0.635
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.367 0.633
I70.1 Atherosclerosis of renal artery
0.000 0.368 0.632
F31.8 Other bipolar affective disorders
0.000 0.368 0.632
H60.5 Acute otitis externa, non-infective
0.000 0.369 0.631
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.369 0.631
L43.3 Subacute (active) lichen planus
0.000 0.370 0.630
L43.2 Lichenoid drug reaction
0.000 0.370 0.630
L43.1 Bullous lichen planus
0.000 0.370 0.630
L43.0 Hypertrophic lichen planus
0.000 0.370 0.630
L40.3 Pustulosis palmaris et plantaris
0.000 0.371 0.629
H61.1 Non-infective disorders of pinna
0.000 0.371 0.629
I70.0 Atherosclerosis of aorta
0.000 0.372 0.628
I70.9 Generalised and unspecified atherosclerosis
0.000 0.372 0.627
I24.1 Dressler's syndrome
0.000 0.373 0.627
F31.2 Bipolar affective disorder, current episode manic with psychotic symptoms
0.000 0.378 0.622
M35.0 Sicca syndrome [Sjogren]
0.000 0.379 0.621
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.380 0.619
I11 Hypertensive heart disease
0.000 0.381 0.619
F30.8 Other manic episodes
0.000 0.382 0.618
F30.1 Mania without psychotic symptoms
0.000 0.382 0.618
M35.2 Behcet's disease
0.000 0.382 0.618
E23.2 Diabetes insipidus
0.000 0.383 0.617
M07.35 Other psoriatic arthropathies (Pelvic region and thigh)
0.000 0.383 0.617
G37.9 Demyelinating disease of central nervous system, unspecified
0.617 0.383 0.000
E72 Other disorders of amino-acid metabolism
0.000 0.385 0.615
I22.0 Subsequent myocardial infarction of anterior wall
0.000 0.386 0.614
E22.0 Acromegaly and pituitary gigantism
0.000 0.389 0.611
M05.96 Seropositive rheumatoid arthritis, unspecified (Lower leg)
0.000 0.390 0.610
I73.9 Peripheral vascular disease, unspecified
0.000 0.390 0.610
I24.9 Acute ischaemic heart disease, unspecified
0.000 0.390 0.610
L00-L08 Infections of the skin and subcutaneous tissue
0.000 0.391 0.609
M00-M03 Infectious arthropathies
0.000 0.393 0.606
H60.8 Other otitis externa
0.000 0.394 0.606
M32 Systemic lupus erythematosus
0.000 0.395 0.605
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.395 0.605
E07.1 Dyshormogenetic goitre
0.000 0.395 0.604
E07.0 Hypersecretion of calcitonin
0.000 0.395 0.604
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.396 0.604
E23.1 Drug-induced hypopituitarism
0.000 0.396 0.604
F99-F99 Unspecified mental disorder
0.000 0.396 0.604
F32 Depressive episode
0.000 0.396 0.604
M06.4 Inflammatory polyarthropathy
0.000 0.398 0.602
I08 Multiple valve diseases
0.000 0.399 0.601
M07.39 Other psoriatic arthropathies (Site unspecified)
0.000 0.400 0.600
E28.9 Ovarian dysfunction, unspecified
0.000 0.402 0.598
E28.8 Other ovarian dysfunction
0.000 0.402 0.598
E28.1 Androgen excess
0.000 0.402 0.598
E28.0 Oestrogen excess
0.000 0.402 0.598
I24.0 Coronary thrombosis not resulting in myocardial infarction
0.000 0.402 0.598
E85.9 Amyloidosis, unspecified
0.000 0.403 0.597
M46.9 Inflammatory spondylopathy, unspecified
0.000 0.403 0.597
E11.6 With other specified complications
0.000 0.404 0.596
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.404 0.596
M75.4 Impingement syndrome of shoulder
0.000 0.405 0.595
I23.6 Thrombosis of atrium, auricular appendage and ventricle as current complications following acute myocardial infarction
0.000 0.405 0.595
I23.5 Rupture of papillary muscle as current complication following acute myocardial infarction
0.000 0.405 0.595
I23.4 Rupture of chordae tendineae as current complication following acute myocardial infarction
0.000 0.405 0.595
I23.3 Rupture of cardiac wall without haemopericardium as current complication following acute myocardial infarction
0.000 0.405 0.595
I23.2 Ventricular septal defect as current complication following acute myocardial infarction
0.000 0.405 0.595
I23.1 Atrial septal defect as current complication following acute myocardial infarction
0.000 0.405 0.595
I23.0 Haemopericardium as current complication following acute myocardial infarction
0.000 0.405 0.595
M34.1 CR(E)ST syndrome
0.000 0.406 0.594
E65-E68 Obesity and other hyperalimentation
0.000 0.406 0.594
E20 Hypoparathyroidism
0.000 0.408 0.591
M70.6 Trochanteric bursitis
0.000 0.409 0.591
E89.3 Postprocedural hypopituitarism
0.000 0.410 0.590
E05.8 Other thyrotoxicosis
0.000 0.410 0.590
I15.8 Other secondary hypertension
0.000 0.410 0.590
I15.2 Hypertension secondary to endocrine disorders
0.000 0.410 0.590
I73.0 Raynaud's syndrome
0.000 0.410 0.590
H60.1 Cellulitis of external ear
0.000 0.411 0.589
E11.8 With unspecified complications
0.000 0.411 0.589
I15.1 Hypertension secondary to other renal disorders
0.000 0.413 0.587
I70.8 Atherosclerosis of other arteries
0.000 0.414 0.586
E27.5 Adrenomedullary hyperfunction
0.000 0.415 0.585
E27.0 Other adrenocortical overactivity
0.000 0.415 0.585
M35.7 Hypermobility syndrome
0.000 0.415 0.585
F60-F69 Disorders of adult personality and behaviour
0.000 0.415 0.584
E21.2 Other hyperparathyroidism
0.000 0.416 0.584
E21.4 Other specified disorders of parathyroid gland
0.000 0.420 0.580
H62 Disorders of external ear in diseases classified elsewhere
0.000 0.421 0.579
M05.2 Rheumatoid vasculitis
0.000 0.421 0.579
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.421 0.579
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.421 0.579
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.421 0.579
E74.2 Disorders of galactose metabolism
0.000 0.421 0.579
E74.1 Disorders of fructose metabolism
0.000 0.421 0.579
M49.5 Collapsed vertebra in diseases classified elsewhere
0.000 0.421 0.579
E15 Nondiabetic hypoglycaemic coma
0.000 0.422 0.578
F70-F79 Mental retardation
0.000 0.424 0.575
L55-L59 Radiation-related disorders of the skin and subcutaneous tissue
0.000 0.430 0.570
M70.5 Other bursitis of knee
0.000 0.431 0.569
I15.0 Renovascular hypertension
0.000 0.432 0.567
E13 Other specified diabetes mellitus
0.000 0.436 0.564
F84 Pervasive developmental disorders
0.000 0.440 0.560
M06.0 Seronegative rheumatoid arthritis
0.000 0.441 0.559
M73 Soft tissue disorders in diseases classified elsewhere
0.000 0.441 0.559
H61.3 Acquired stenosis of external ear canal
0.000 0.442 0.558
H60.2 Malignant otitis externa
0.000 0.443 0.557
I74.5 Embolism and thrombosis of iliac artery
0.000 0.443 0.557
I79.8 Other disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.000 0.444 0.556
I79.1 Aortitis in diseases classified elsewhere
0.000 0.444 0.556
I79.0 Aneurysm of aorta in diseases classified elsewhere
0.000 0.444 0.556
F89 Unspecified disorder of psychological development
0.000 0.445 0.554
F88 Other disorders of psychological development
0.000 0.445 0.554
F83 Mixed specific developmental disorders
0.000 0.445 0.554
F82 Specific developmental disorder of motor function
0.000 0.445 0.554
E50-E64 Other nutritional deficiencies
0.000 0.446 0.554
E85.2 Heredofamilial amyloidosis, unspecified
0.000 0.446 0.554
E85.1 Neuropathic heredofamilial amyloidosis
0.000 0.446 0.554
E85.0 Nonneuropathic heredofamilial amyloidosis
0.000 0.446 0.554
E34 Other endocrine disorders
0.000 0.448 0.552
I74.1 Embolism and thrombosis of other and unspecified parts of aorta
0.000 0.450 0.550
F80.1 Expressive language disorder
0.000 0.451 0.549
M70.9 Unspecified soft tissue disorder related to use, overuse and pressure
0.000 0.451 0.549
M70.8 Other soft tissue disorders related to use, overuse and pressure
0.000 0.451 0.549
M70.1 Bursitis of hand
0.000 0.451 0.549
M70.0 Chronic crepitant synovitis of hand and wrist
0.000 0.451 0.549
I74.9 Embolism and thrombosis of unspecified artery
0.000 0.451 0.549
F31.4 Bipolar affective disorder, current episode severe depression without psychotic symptoms
0.000 0.452 0.548
H65-H75 Diseases of middle ear and mastoid
0.000 0.452 0.548
F50-F59 Behavioural syndromes associated with physiological disturbances and physical factors
0.000 0.454 0.546
M70.49 Prepatellar bursitis-Site unspec
0.000 0.457 0.543
M70.48 Prepatellar bursitis-Other
0.000 0.457 0.543
M70.47 Prepatellar bursitis-Ankle/Foot
0.000 0.457 0.543
M70.45 Prepatellar bursitis-Pelvic/Thigh
0.000 0.457 0.543
M70.44 Prepatellar bursitis-Hand
0.000 0.457 0.543
M70.43 Prepatellar bursitis-Forearm
0.000 0.457 0.543
M70.42 Prepatellar bursitis-Upper arm
0.000 0.457 0.543
M70.41 Prepatellar bursitis-Shldr region
0.000 0.457 0.543
M70.40 Prepatellar bursitis-Mult sites
0.000 0.457 0.543
I08.1 Disorders of both mitral and tricuspid valves
0.000 0.457 0.543
M34.9 Systemic sclerosis, unspecified
0.000 0.458 0.542
F34.1 Dysthymia
0.000 0.458 0.542
M35.9 Systemic involvement of connective tissue, unspecified
0.000 0.459 0.541
M35.6 Relapsing panniculitis [Weber-Christian]
0.000 0.459 0.541
M35.5 Multifocal fibrosclerosis
0.000 0.459 0.541
M35.4 Diffuse (eosinophilic) fasciitis
0.000 0.459 0.541
M60-M63 Disorders of muscles
0.000 0.461 0.538
M46.92 Inflammatory spondylopathy, unspecified (Cervical region)
0.000 0.462 0.538
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.462 0.538
M14 Arthropathies in other diseases classified elsewhere
0.000 0.462 0.537
M49.8 Spondylopathy in other diseases classified elsewhere
0.000 0.462 0.538
M49.4 Neuropathic spondylopathy
0.000 0.462 0.538
M49.3 Spondylopathy in other infectious and parasitic diseases classified elsewhere
0.000 0.462 0.538
M49.2 Enterobacterial spondylitis
0.000 0.462 0.538
M49.1 Brucella spondylitis
0.000 0.462 0.538
M49.0 Tuberculosis of spine
0.000 0.462 0.538
I25.3 Aneurysm of heart
0.000 0.463 0.537
M70.2 Olecranon bursitis
0.000 0.463 0.537
M93 Other osteochondropathies
0.000 0.464 0.536
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.000 0.464 0.536
F81.9 Developmental disorder of scholastic skills, unspecified
0.000 0.465 0.535
E16.2 Hypoglycaemia, unspecified
0.000 0.466 0.534
M75.2 Bicipital tendinitis
0.000 0.466 0.534
M24 Other specific joint derangements
0.000 0.466 0.534
I21.0 Acute transmural myocardial infarction of anterior wall
0.000 0.467 0.533
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.468 0.532
E22.8 Other hyperfunction of pituitary gland
0.000 0.468 0.532
I73.8 Other specified peripheral vascular diseases
0.000 0.469 0.531
M33 Dermatopolymyositis
0.000 0.469 0.530
I08.0 Disorders of both mitral and aortic valves
0.000 0.469 0.531
I73.1 Thromboangiitis obliterans [Buerger]
0.000 0.472 0.528
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.474 0.526
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.477 0.523
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.477 0.523
E79.1 Lesch-Nyhan syndrome
0.000 0.477 0.523
I74.8 Embolism and thrombosis of other arteries
0.000 0.478 0.522
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.478 0.521
E16.1 Other hypoglycaemia
0.000 0.479 0.521
E83 Disorders of mineral metabolism
0.149 0.480 0.371
E84.9 Cystic fibrosis, unspecified
0.000 0.480 0.520
H60.4 Cholesteatoma of external ear
0.000 0.481 0.519
I09 Other rheumatic heart diseases
0.000 0.482 0.518
E84.8 Cystic fibrosis with other manifestations
0.000 0.484 0.516
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.484 0.516
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.484 0.516
M70.3 Other bursitis of elbow
0.000 0.485 0.515
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.486 0.514
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.486 0.514
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.486 0.514
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.486 0.514
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.486 0.514
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.486 0.514
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.486 0.514
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.486 0.514
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
M06.19 Adult-onset Still's disease (Site unspecified)
0.000 0.486 0.513
M06.18 Adult-onset Still's disease (Other)
0.000 0.486 0.513
M06.17 Adult-onset Still's disease (Ankle and foot)
0.000 0.486 0.513
M06.16 Adult-onset Still's disease (Lower leg)
0.000 0.486 0.513
M06.15 Adult-onset Still's disease (Pelvic region and thigh)
0.000 0.486 0.513
M06.14 Adult-onset Still's disease (Hand)
0.000 0.486 0.513
M06.13 Adult-onset Still's disease (Forearm)
0.000 0.486 0.513

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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