TreeWAS – Variant ID: rs1524976

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
K76.6 Portal hypertension	0.000	0.887	0.113
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs	0.000	0.896	0.104
T42.6 Other antiepileptic and sedative-hypnotic drugs	0.000	0.897	0.103
K76.9 Liver disease, unspecified	0.000	0.898	0.102
K76 Other diseases of liver	0.000	0.898	0.102
T36-T50 Poisoning by drugs, medicaments and biological substances	0.000	0.900	0.100
T42.4 Benzodiazepines	0.000	0.903	0.097
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]	0.000	0.905	0.095
T43 Poisoning by psychotropic drugs, not elsewhere classified	0.000	0.905	0.095
T40.2 Other opioids	0.000	0.907	0.093
K70-K77 Diseases of liver	0.000	0.912	0.088
T46 Poisoning by agents primarily affecting the cardiovascular system	0.000	0.915	0.085
K74 Fibrosis and cirrhosis of liver	0.000	0.916	0.084
K70 Alcoholic liver disease	0.000	0.918	0.082
T43.2 Other and unspecified antidepressants	0.000	0.918	0.082
K74.6 Other and unspecified cirrhosis of liver	0.000	0.919	0.081
K70.3 Alcoholic cirrhosis of liver	0.000	0.919	0.081
T42.7 Antiepileptic and sedative-hypnotic drugs, unspecified	0.000	0.919	0.081
T47 Poisoning by agents primarily affecting gastro-intestinal system	0.000	0.919	0.081
T44 Poisoning by drugs primarily affecting the autonomic nervous system	0.000	0.919	0.081
T42.0 Hydantoin derivatives	0.000	0.921	0.079
T40.5 Cocaine	0.000	0.921	0.079
T43.6 Psychostimulants with abuse potential	0.000	0.922	0.078
T36 Poisoning by systemic antibiotics	0.000	0.923	0.077
K76.1 Chronic passive congestion of liver	0.000	0.924	0.076
T43.3 Phenothiazine antipsychotics and neuroleptics	0.000	0.924	0.076
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs	0.000	0.924	0.076
T42.8 Anti-Parkinsonism drugs and other central muscle-tone depressants	0.000	0.924	0.075
T43.9 Psychotropic drug, unspecified	0.000	0.925	0.075
T43.4 Butyrophenone and thioxanthene neuroleptics	0.000	0.925	0.075
T42.5 Mixed antiepileptics, not elsewhere classified	0.000	0.925	0.075
T42.2 Succinimides and oxazolidinediones	0.000	0.925	0.075
T46.4 Angiotensin-converting-enzyme inhibitors	0.000	0.926	0.074
T40.3 Methadone	0.000	0.927	0.073
K76.5 Hepatic veno-occlusive disease	0.000	0.927	0.073
K76.4 Peliosis hepatis	0.000	0.927	0.073
K76.2 Central haemorrhagic necrosis of liver	0.000	0.927	0.073
Z03.4 Observation for suspected myocardial infarction	0.072	0.928	0.000
T41 Poisoning by anaesthetics and therapeutic gases	0.000	0.928	0.072
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system	0.000	0.930	0.070
K74.5 Biliary cirrhosis, unspecified	0.000	0.930	0.070
K76.3 Infarction of liver	0.000	0.930	0.070
T47.1 Other antacids and anti-gastric-secretion drugs	0.000	0.931	0.069
T40.1 Heroin	0.000	0.931	0.069
T43.0 Tricyclic and tetracyclic antidepressants	0.000	0.931	0.069
T40.9 Other and unspecified psychodysleptics [hallucinogens]	0.000	0.932	0.068
T40.8 Lysergide [LSD]	0.000	0.932	0.068
T40.7 Cannabis (derivatives)	0.000	0.932	0.068
T40.0 Opium	0.000	0.932	0.068
T43.8 Other psychotropic drugs, not elsewhere classified	0.000	0.932	0.068
T37 Poisoning by other systemic anti-infectives and antiparasitics	0.000	0.932	0.068
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances	0.000	0.933	0.067
T46.0 Cardiac-stimulant glycosides and drugs of similar action	0.000	0.933	0.067
T43.1 Monoamine-oxidase-inhibitor antidepressants	0.000	0.934	0.066
T42.3 Barbiturates	0.000	0.934	0.066
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified	0.000	0.935	0.065
T46.9 Other and unspecified agents primarily affecting the cardiovascular system	0.000	0.935	0.065
T44.7 Beta-Adrenoreceeptor antagonists, not elsewhere classified	0.000	0.935	0.065
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified	0.000	0.935	0.065
T43.5 Other and unspecified antipsychotics and neuroleptics	0.000	0.935	0.065
T44.3 Other parasympatholytics [anticholinergics and antimuscarines] and spasmolytics, not elsewhere classified	0.000	0.936	0.064
K71 Toxic liver disease	0.000	0.936	0.064
K72 Hepatic failure, not elsewhere classified	0.000	0.936	0.064
T46.1 Calcium-channel blockers	0.000	0.936	0.063
K77 Liver disorders in diseases classified elsewhere	0.000	0.937	0.063
T42.1 Iminostilbenes	0.000	0.937	0.063
T47.4 Other laxatives	0.000	0.938	0.062
K74.3 Primary biliary cirrhosis	0.000	0.938	0.062
K76.7 Hepatorenal syndrome	0.000	0.938	0.062
T46.8 Antivaricose drugs, including sclerosing agents	0.000	0.939	0.061
T46.7 Peripheral vasodilators	0.000	0.939	0.061
K74.4 Secondary biliary cirrhosis	0.000	0.939	0.061
K74.2 Hepatic fibrosis with hepatic sclerosis	0.000	0.939	0.061
K70.2 Alcoholic fibrosis and sclerosis of liver	0.000	0.940	0.060
T36.0 Penicillins	0.000	0.940	0.059
T36.3 Macrolides	0.000	0.941	0.059
K70.9 Alcoholic liver disease, unspecified	0.000	0.941	0.059
T40.4 Other synthetic narcotics	0.000	0.941	0.059
T46.2 Other antidysrhythmic drugs, not elsewhere classified	0.000	0.941	0.059
K74.1 Hepatic sclerosis	0.000	0.941	0.059
T49.0 Local antifungal, anti-infective and anti-inflammatory drugs, not elsewhere classified	0.000	0.941	0.058
T47.9 Agent primarily affecting the gastro-intestinal system, unspecified	0.000	0.942	0.058
T47.8 Other agents primarily affecting the gastro-intestinal system	0.000	0.942	0.058
T47.7 Emetics	0.000	0.942	0.058
T47.5 Digestants	0.000	0.942	0.058
T47.3 Saline and osmotic laxatives	0.000	0.942	0.058
T44.8 Centrally acting and afrenergic-neuron-blocking agents, not elsewhere classified	0.000	0.942	0.058
T44.5 Predominantly Beta-adrenoreceptor agonists, not elsewhere classified	0.000	0.942	0.058
T44.4 Predominantly Alpha-adrenoreceptor agonists, not elsewhere classified	0.000	0.942	0.058
T44.2 Ganglionic blocking drugs, not elsewhere classified	0.000	0.942	0.058
T44.1 Other parasympathomimetics [cholinergics]	0.000	0.942	0.058
T44.0 Anticholinesterase agents	0.000	0.942	0.058
T47.2 Stimulant laxatives	0.000	0.942	0.058
T47.6 Antidiarrhoeal drugs	0.000	0.943	0.057
K70.1 Alcoholic hepatitis	0.000	0.943	0.057
T44.9 Other and unspecified drugs primarily affecting the nervous system	0.000	0.944	0.056
T46.5 Other antihypertensive drugs, not elsewhere classified	0.000	0.944	0.056
T46.6 Antihyperlipidaemic and antiarteriosclerotic drugs	0.000	0.944	0.056
K70.0 Alcoholic fatty liver	0.000	0.944	0.056
T36.4 Tetracyclines	0.000	0.944	0.056
T44.6 Alpha-Adrenoreceeptor antagonists, not elsewhere classified	0.000	0.944	0.055
K74.0 Hepatic fibrosis	0.000	0.945	0.055
T45.0 Antiallergic and antiemetic drugs	0.000	0.945	0.055
T46.3 Coronary vasodilators, not elsewhere classified	0.000	0.945	0.055
T36.9 Systemic antibiotic, unspecified	0.000	0.945	0.055
T36.7 Antifungal antibiotics, systemically used	0.000	0.945	0.055
T36.6 Rifamycins	0.000	0.945	0.055
T36.5 Aminoglycosides	0.000	0.945	0.055
T36.2 Chloramphenicol group	0.000	0.945	0.055
T36.8 Other systemic antibiotics	0.000	0.945	0.055
T49.9 Topical agent, unspecified	0.000	0.945	0.054
T49.8 Other topical agents	0.000	0.945	0.054
T49.7 Dental drugs, topically applied	0.000	0.945	0.054
T49.6 Otorhinolaryngological drugs and preparations	0.000	0.945	0.054
T49.5 Ophthalmological drugs and preparations	0.000	0.945	0.054
T49.4 Keratolytics, keratoplastics and other hair treatment drugs and preparations	0.000	0.945	0.054
T49.3 Emollients, demulcents and protectants	0.000	0.945	0.054
T49.2 Local astringents and local detergents	0.000	0.945	0.054
T49.1 Antipruritics	0.000	0.945	0.054
K70.4 Alcoholic hepatic failure	0.000	0.946	0.053
K73 Chronic hepatitis, not elsewhere classified	0.000	0.947	0.053
T50.9 Other and unspecified drugs, medicaments and biological substances	0.000	0.947	0.053
T41.2 Other and unspecified general anaesthetics	0.000	0.948	0.052
T41.5 Therapeutic gases	0.000	0.948	0.052
T41.4 Anaesthetic, unspecified	0.000	0.948	0.052
T41.3 Local anaesthetics	0.000	0.948	0.052
T41.1 Intravenous anaesthetics	0.000	0.948	0.052
T41.0 Inhaled anaesthetics	0.000	0.948	0.052
K72.1 Chronic hepatic failure	0.000	0.948	0.052
T48.5 Anti-common-cold drugs	0.000	0.949	0.051
T36.1 Cefalosporins and other Beta-lactam antibiotics	0.000	0.949	0.051
T38.1 Thyroid hormones and substitutes	0.000	0.949	0.051
T48.7 Other and unspecified agents primarily acting on the respiratory system	0.000	0.949	0.050
T48.4 Expectorants	0.000	0.949	0.050
T48.3 Antitussives	0.000	0.949	0.050
T48.2 Other and unspecified agents primarily acting on muscles	0.000	0.949	0.050
T48.1 Skeletal muscle relaxants [neuromuscular blocking agents]	0.000	0.949	0.050
T48.0 Oxytocic drugs	0.000	0.949	0.050
T50.1 Loop [high-ceiling] diuretics	0.000	0.950	0.050
T47.0 Histamine H(2)-receptor antagonists	0.000	0.950	0.050
T37.9 Systemic anti-infective and antiparasitic, unspecified	0.000	0.951	0.049
T37.5 Antiviral drugs	0.000	0.951	0.049
T37.4 Anthelminthics	0.000	0.951	0.049
T37.3 Other antiprotozoal drugs	0.000	0.951	0.049
T37.1 Antimycobacterial drugs	0.000	0.951	0.049
T37.0 Sulphonamides	0.000	0.951	0.049
K71.9 Toxic liver disease, unspecified	0.000	0.951	0.049
T38.8 Other and unspecified hormones and their synthetic substitutes	0.000	0.952	0.048
T48.6 Antiasthmatics, not elsewhere classified	0.000	0.952	0.048
T50.7 Analeptics and opioid receptor antagonists	0.000	0.952	0.048
T50.5 Appetite depressants	0.000	0.952	0.048
T50.3 Electrolytic, caloric and water-balance agents	0.000	0.952	0.048
T50.0 Mineralocorticoids and their antagonists	0.000	0.952	0.048
T37.8 Other specified systemic anti-infectives and antiparasitics	0.000	0.952	0.048
T50.2 Carbonic-anhydrase inhibitors, benzothiadiazides and other diuretics	0.000	0.952	0.048
T45.9 Primarily systemic and haematological agent, unspecified	0.000	0.953	0.047
T45.8 Other primarily systemic and haematological agents	0.000	0.953	0.047
T45.7 Anticoagulant antagonists, vitamin K and other coagulants	0.000	0.953	0.047
T45.6 Fibrinolysis-affecting drugs	0.000	0.953	0.047
T45.3 Enzymes, not elsewhere classified	0.000	0.953	0.047
T40.6 Other and unspecified narcotics	0.000	0.953	0.046
T38.9 Other and unspecified hormone antagonists	0.000	0.953	0.047
T38.7 Androgens and anabolic congeners	0.000	0.953	0.047
T38.4 Oral contraceptives	0.000	0.953	0.047
T38.2 Antithyroid drugs	0.000	0.953	0.047
T37.2 Antimalarials and drugs acting on other blood protozoa	0.000	0.953	0.047
T50.6 Antidotes and chelating agents, not elsewhere classified	0.000	0.954	0.046
K71.8 Toxic liver disease with other disorders of liver	0.000	0.954	0.046
K71.7 Toxic liver disease with fibrosis and cirrhosis of liver	0.000	0.954	0.046
K71.5 Toxic liver disease with chronic active hepatitis	0.000	0.954	0.046
K71.4 Toxic liver disease with chronic lobular hepatitis	0.000	0.954	0.046
K71.3 Toxic liver disease with chronic persistent hepatitis	0.000	0.954	0.046
K71.2 Toxic liver disease with acute hepatitis	0.000	0.954	0.046
K71.6 Toxic liver disease with hepatitis, not elsewhere classified	0.000	0.954	0.046
K77.0 Liver disorders in infectious and parasitic diseases classified elsewhere	0.000	0.954	0.046
K71.1 Toxic liver disease with hepatic necrosis	0.000	0.954	0.045
K77.8 Liver disorders in other diseases classified elsewhere	0.000	0.955	0.045
K76.8 Other specified diseases of liver	0.000	0.955	0.045
T38.3 Insulin and oral hypoglycaemic [antidiabetic] drugs	0.000	0.955	0.045
T45.5 Anticoagulants	0.000	0.955	0.045
T50.8 Diagnostic agents	0.000	0.955	0.044
T38.0 Glucocorticoids and synthetic analogues	0.000	0.955	0.044
K71.0 Toxic liver disease with cholestasis	0.000	0.956	0.044
T45.2 Vitamins, not elsewhere classified	0.000	0.956	0.044
T45.4 Iron and its compounds	0.000	0.956	0.043
T38.5 Other oestrogens and progestogens	0.000	0.957	0.043
K72.9 Hepatic failure, unspecified	0.000	0.957	0.043
K75 Other inflammatory liver diseases	0.000	0.957	0.043
T50.4 Drugs affecting uric acid metabolism	0.000	0.958	0.042
K72.0 Acute and subacute hepatic failure	0.000	0.958	0.042
T38.6 Antigonadotrophins. antioestrogens, antiandrogens, not elsewhere classified	0.000	0.958	0.041
K73.8 Other chronic hepatitis, not elsewhere classified	0.000	0.961	0.039
K73.1 Chronic lobular hepatitis, not elsewhere classified	0.000	0.962	0.038
K73.0 Chronic persistent hepatitis, not elsewhere classified	0.000	0.962	0.038
T45.1 Antineoplastic and immunosuppressive drugs	0.000	0.962	0.038
K73.2 Chronic active hepatitis, not elsewhere classified	0.000	0.962	0.038
K75.2 Nonspecific reactive hepatitis	0.000	0.969	0.031
K75.1 Phlebitis of portal vein	0.000	0.969	0.031
K75.0 Abscess of liver	0.000	0.970	0.030
K75.8 Other specified inflammatory liver diseases	0.000	0.971	0.029
K73.9 Chronic hepatitis, unspecified	0.000	0.972	0.028
K75.3 Granulomatous hepatitis, not elsewhere classified	0.000	0.972	0.027
K75.9 Inflammatory liver disease, unspecified	0.000	0.973	0.027
K75.4 Autoimmune hepatitis	0.000	0.974	0.026
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics	0.000	0.980	0.020
T39.9 Nonopioid analgesic, antipyretic and antirheumatic, unspecified	0.000	0.983	0.016
T39.4 Antirheumatics, not elsewhere classified	0.000	0.985	0.015
T39.2 Pyrazolone derivatives	0.000	0.985	0.015
T39.8 Other nonopioid analgesics and antipyretics, not elsewhere classified	0.000	0.988	0.012
N13.6 Pyonephrosis	0.000	0.991	0.009
N13.5 Kinking and stricture of ureter without hydronephrosis	0.000	0.991	0.009
N13 Obstructive and reflux uropathy	0.000	0.991	0.009
T39.3 Other nonsteroidal anti-inflammatory drugs [NSAID]	0.000	0.991	0.009
N50.8 Other specified disorders of male genital organs	0.008	0.992	0.000
N13.0 Hydronephrosis with ureteropelvic junction obstruction	0.000	0.992	0.008
K13.7 Other and unspecified lesions of oral mucosa	0.000	0.992	0.008
T39.0 Salicylates	0.000	0.992	0.008
K13.0 Diseases of lips	0.000	0.992	0.008
N13.8 Other obstructive and reflux uropathy	0.000	0.992	0.008
N13.3 Other and unspecified hydronephrosis	0.000	0.992	0.008
K76.0 Fatty (change of) liver, not elsewhere classified	0.000	0.993	0.007
N13.7 Vesicoureteral-reflux-associated uropathy	0.000	0.993	0.007
N13.1 Hydronephrosis with ureteral stricture, not elsewhere classified	0.000	0.993	0.007
K13 Other diseases of lip and oral mucosa	0.000	0.994	0.006
T39.1 4-Aminophenol derivatives	0.000	0.994	0.006
N13.2 Hydronephrosis with renal and ureteral calculous obstruction	0.000	0.994	0.006
C43.7 Malignant melanoma of lower limb, including hip	0.000	0.994	0.006
C77.3 Axillary and upper limb lymph nodes	0.005	0.995	0.000
N13.9 Obstructive and reflux uropathy, unspecified	0.000	0.995	0.005
X41.9 Unspecified place	0.000	0.995	0.005
N13.4 Hydroureter	0.000	0.995	0.005
K13.5 Oral submucous fibrosis	0.000	0.995	0.005
K13.2 Leukoplakia and other disturbances of oral epithelium, including tongue	0.000	0.995	0.005
K13.3 Hairy leukoplakia	0.000	0.995	0.005
N90.4 Leukoplakia of vulva	0.005	0.995	0.000
N64.1 Fat necrosis of breast	0.000	0.995	0.005
N90.6 Hypertrophy of vulva	0.004	0.996	0.000
E27.1 Primary adrenocortical insufficiency	0.000	0.996	0.004
K13.1 Cheek and lip biting	0.000	0.996	0.004
K92.2 Gastro-intestinal haemorrhage, unspecified	0.000	0.996	0.004
N90 Other noninflammatory disorders of vulva and perineum	0.004	0.996	0.000
N90.8 Other specified noninflammatory disorders of vulva and perineum	0.004	0.996	0.000
E27 Other disorders of adrenal gland	0.000	0.996	0.004
J98.1 Pulmonary collapse	0.000	0.996	0.004
C67 Malignant neoplasm of bladder	0.004	0.996	0.000
S92.30 Fracture of metatarsal bone (closed)	0.004	0.996	0.000
C67.6 Ureteric orifice	0.004	0.996	0.000
C67.5 Bladder neck	0.004	0.996	0.000
E27.4 Other and unspecified adrenocortical insufficiency	0.000	0.996	0.004
K13.6 Irritative hyperplasia of oral mucosa	0.000	0.996	0.004
N90.1 Moderate vulvar dysplasia	0.004	0.996	0.000
K13.29 Other disturbances of oral epithelium, including tongue	0.000	0.996	0.003
N90.3 Dysplasia of vulva, unspecified	0.004	0.996	0.000
E34.8 Other specified endocrine disorders	0.000	0.996	0.004
E27.8 Other specified disorders of adrenal gland	0.000	0.996	0.004
E20-E35 Disorders of other endocrine glands	0.000	0.996	0.004
N81.3 Complete uterovaginal prolapse	0.000	0.996	0.004
C67.1 Dome of bladder	0.003	0.996	0.000
E34 Other endocrine disorders	0.000	0.996	0.003
C67.3 Anterior wall of bladder	0.003	0.996	0.000
E22.0 Acromegaly and pituitary gigantism	0.000	0.996	0.003
K13.4 Granuloma and granuloma-like lesions of oral mucosa	0.000	0.996	0.003
C67.9 Bladder, unspecified	0.003	0.997	0.000
E24 Cushing's syndrome	0.000	0.997	0.003
E24.9 Cushing's syndrome, unspecified	0.000	0.997	0.003
N90.9 Noninflammatory disorder of vulva and perineum, unspecified	0.003	0.997	0.000
N90.0 Mild vulvar dysplasia	0.003	0.997	0.000
E21 Hyperparathyroidism and other disorders of parathyroid gland	0.000	0.997	0.003
N90.2 Severe vulvar dysplasia, not elsewhere classified	0.003	0.997	0.000
E22 Hyperfunction of pituitary gland	0.000	0.997	0.003
E27.5 Adrenomedullary hyperfunction	0.000	0.997	0.003
E27.0 Other adrenocortical overactivity	0.000	0.997	0.003
N50 Other disorders of male genital organs	0.003	0.997	0.000
C67.4 Posterior wall of bladder	0.003	0.997	0.000
E27.2 Addisonian crisis	0.000	0.997	0.003
C67.0 Trigone of bladder	0.003	0.997	0.000
K56.4 Other impaction of intestine	0.003	0.997	0.000
C67.7 Urachus	0.003	0.997	0.000
E21.1 Secondary hyperparathyroidism, not elsewhere classified	0.000	0.997	0.003
H50.0 Convergent concomitant strabismus	0.003	0.997	0.000
X41 Accidental poisoning by and exposure to antiepileptic, sedative-hypnotic, anti-Parkinsonism and psychotropic drugs, not elsewhere classified	0.000	0.997	0.003
E21.3 Hyperparathyroidism, unspecified	0.000	0.997	0.003
F33.2 Recurrent depressive disorder, current episode severe without psychotic symptoms	0.000	0.997	0.003
E26 Hyperaldosteronism	0.000	0.997	0.003
N99.3 Prolapse of vaginal vault after hysterectomy	0.003	0.997	0.000
C67.8 Overlapping lesion of bladder	0.003	0.997	0.000
N50.9 Disorder of male genital organs, unspecified	0.003	0.997	0.000
E23.2 Diabetes insipidus	0.000	0.997	0.003
E27.9 Disorder of adrenal gland, unspecified	0.000	0.997	0.003
E23 Hypofunction and other disorders of pituitary gland	0.000	0.997	0.003
E27.3 Drug-induced adrenocortical insufficiency	0.000	0.997	0.003
R59.9 Enlarged lymph nodes, unspecified	0.000	0.997	0.003
E34.0 Carcinoid syndrome	0.000	0.997	0.003
E35 Disorders of endocrine glands in diseases classified elsewhere	0.000	0.997	0.003
E32 Diseases of thymus	0.000	0.997	0.003
E30 Disorders of puberty, not elsewhere classified	0.000	0.997	0.003
E31 Polyglandular dysfunction	0.000	0.997	0.003
E24.2 Drug-induced Cushing's syndrome	0.000	0.997	0.003
E21.5 Disorder of parathyroid gland, unspecified	0.000	0.997	0.003
E34.5 Androgen resistance syndrome	0.000	0.997	0.003
E34.4 Constitutional tall stature	0.000	0.997	0.003
E34.2 Ectopic hormone secretion, not elsewhere classified	0.000	0.997	0.003
E34.1 Other hypersecretion of intestinal hormones	0.000	0.997	0.003
N90.7 Vulvar cyst	0.003	0.997	0.000
E25 Adrenogenital disorders	0.000	0.997	0.003
E24.0 Pituitary-dependent Cushing's disease	0.000	0.997	0.003
E21.4 Other specified disorders of parathyroid gland	0.000	0.997	0.003
L72.1 Trichilemmal cyst	0.003	0.997	0.000
E24.4 Alcohol-induced pseudo-Cushing's syndrome	0.000	0.997	0.003
E24.3 Ectopic ACTH syndrome	0.000	0.997	0.003
E24.1 Nelson's syndrome	0.000	0.997	0.003
E34.9 Endocrine disorder, unspecified	0.000	0.997	0.003
E34.3 Short stature, not elsewhere classified	0.000	0.997	0.003
N50.0 Atrophy of testis	0.003	0.997	0.000
E26.9 Hyperaldosteronism, unspecified	0.000	0.997	0.003
E24.8 Other Cushing's syndrome	0.000	0.997	0.002
C67.2 Lateral wall of bladder	0.003	0.997	0.000
E22.8 Other hyperfunction of pituitary gland	0.000	0.997	0.002
E22.9 Hyperfunction of pituitary gland, unspecified	0.000	0.997	0.002
X41.2 School, other institution and public administrative area	0.000	0.997	0.002
N10-N16 Renal tubulo-interstitial diseases	0.000	0.997	0.003
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone	0.000	0.997	0.003
E20 Hypoparathyroidism	0.000	0.997	0.002
M84.16 Nonunion of fracture [pseudarthrosis] (Lower leg)	0.003	0.997	0.000
E26.0 Primary hyperaldosteronism	0.000	0.997	0.002
E21.2 Other hyperparathyroidism	0.000	0.997	0.002
X41.0 Home	0.000	0.997	0.002
X41.8 Other specified place	0.000	0.997	0.002
X41.7 Farm	0.000	0.997	0.002
X41.6 Industrial and construction area	0.000	0.997	0.002
X41.5 Trade and service area	0.000	0.997	0.002
X41.4 Street and highway	0.000	0.997	0.002
X41.3 Sports and athletics area	0.000	0.997	0.002
X41.1 Residential institution	0.000	0.997	0.002
E26.8 Other hyperaldosteronism	0.000	0.997	0.002
E26.1 Secondary hyperaldosteronism	0.000	0.997	0.002
E29 Testicular dysfunction	0.000	0.997	0.002
Q43.0 Meckel's diverticulum	0.002	0.998	0.000
N11 Chronic tubulo-interstitial nephritis	0.000	0.998	0.002
H50.5 Heterophoria	0.002	0.998	0.000
Z85.6 Personal history of leukaemia	0.000	0.998	0.002
O34.4 Maternal care for other abnormalities of cervix	0.002	0.998	0.000
E23.3 Hypothalamic dysfunction, not elsewhere classified	0.000	0.998	0.002
E23.1 Drug-induced hypopituitarism	0.000	0.998	0.002
N11.9 Chronic tubulo-interstitial nephritis, unspecified	0.000	0.998	0.002
H50 Other strabismus	0.002	0.998	0.000
E30.9 Disorder of puberty, unspecified	0.000	0.998	0.002
E30.8 Other disorders of puberty	0.000	0.998	0.002
E30.1 Precocious puberty	0.000	0.998	0.002
E30.0 Delayed puberty	0.000	0.998	0.002
E31.9 Polyglandular dysfunction, unspecified	0.000	0.998	0.002
E31.8 Other polyglandular dysfunction	0.000	0.998	0.002
E31.1 Polyglandular hyperfunction	0.000	0.998	0.002
E32.9 Disease of thymus, unspecified	0.000	0.998	0.002
E32.8 Other diseases of thymus	0.000	0.998	0.002
E32.1 Abscess of thymus	0.000	0.998	0.002
E32.0 Persistent hyperplasia of thymus	0.000	0.998	0.002
E35.8 Disorders of other endocrine glands in diseases classified elsewhere	0.000	0.998	0.002
E35.1 Disorders of adrenal glands in diseases classified elsewhere	0.000	0.998	0.002
E35.0 Disorders of thyroid gland in diseases classified elsewhere	0.000	0.998	0.002
E31.0 Autoimmune polyglandular failure	0.000	0.998	0.002
K11.2 Sialoadenitis	0.000	0.998	0.002
Z35.5 Supervision of elderly primigravida	0.002	0.998	0.000
E25.9 Adrenogenital disorder, unspecified	0.000	0.998	0.002
E25.8 Other adrenogenital disorders	0.000	0.998	0.002
R22.4 Localised swelling, mass and lump, lower limb	0.002	0.998	0.000
M84.1 Nonunion of fracture [pseudarthrosis]	0.002	0.998	0.000
M84.03 Malunion of fracture (Forearm)	0.002	0.998	0.000
E23.7 Disorder of pituitary gland, unspecified	0.000	0.998	0.002
C49.5 Connective and soft tissue of pelvis	0.000	0.998	0.002
N99 Postprocedural disorders of genito-urinary system, not elsewhere classified	0.002	0.998	0.000
M84.18 Nonunion of fracture [pseudarthrosis] (Other)	0.002	0.998	0.000
M84.13 Nonunion of fracture [pseudarthrosis] (Forearm)	0.002	0.998	0.000
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency	0.000	0.998	0.002
C49.1 Connective and soft tissue of upper limb, including shoulder	0.000	0.998	0.002
E22.1 Hyperprolactinaemia	0.000	0.998	0.002
M84.0 Malunion of fracture	0.002	0.998	0.000
N99.0 Postprocedural renal failure	0.002	0.998	0.000
N16 Renal tubulo-interstitial disorders in diseases classified elsewhere	0.000	0.998	0.002
N14 Drug- and heavy-metal-induced tubulo-interstitial and tubular conditions	0.000	0.998	0.002
M84.02 Malunion of fracture (Upper arm)	0.002	0.998	0.000
O34.7 Maternal care for abnormality of vulva and perineum	0.002	0.998	0.000
H90.3 Sensorineural hearing loss, bilateral	0.002	0.998	0.000
D14.0 Middle ear, nasal cavity and accessory sinuses	0.000	0.998	0.002
E23.6 Other disorders of pituitary gland	0.000	0.998	0.002
H50.9 Strabismus, unspecified	0.002	0.998	0.000
L03.9 Cellulitis, unspecified	0.000	0.998	0.002
N99.2 Postprocedural adhesions of vagina	0.002	0.998	0.000
S92.3 Fracture of metatarsal bone	0.002	0.998	0.000
O34 Maternal care for known or suspected abnormality of pelvic organs	0.002	0.998	0.000
E20.1 Pseudohypoparathyroidism	0.000	0.998	0.002
E20.0 Idiopathic hypoparathyroidism	0.000	0.998	0.002
N64.4 Mastodynia	0.000	0.998	0.002
M25.84 Other specified joint disorders (Hand)	0.000	0.998	0.002
C49.3 Connective and soft tissue of thorax	0.000	0.998	0.002
E21.0 Primary hyperparathyroidism	0.000	0.998	0.002
I85.0 Oesophageal varices with bleeding	0.000	0.998	0.002
M84.14 Nonunion of fracture [pseudarthrosis] (Hand)	0.002	0.998	0.000
X41.08 Accidental poisoning by and exposure to antiepileptic, sedative-hypnotic, antiparkinsonism and psychotropic drugs, not elsewhere classified , Home ,While engaged in other specified activities	0.000	0.998	0.002
N99.1 Postprocedural urethral stricture	0.002	0.998	0.000
E29.8 Other testicular dysfunction	0.000	0.998	0.002
E29.0 Testicular hyperfunction	0.000	0.998	0.002
N64 Other disorders of breast	0.000	0.998	0.002
N11.0 Nonobstructive reflux-associated chronic pyelonephritis	0.000	0.998	0.002
N90.5 Atrophy of vulva	0.002	0.998	0.000
O42.9 Premature rupture of membranes, unspecified	0.002	0.998	0.000
C65 Malignant neoplasm of renal pelvis	0.002	0.998	0.000
N11.8 Other chronic tubulo-interstitial nephritis	0.000	0.998	0.002
C49 Malignant neoplasm of other connective and soft tissue	0.000	0.998	0.002
M84.05 Malunion of fracture (Pelvic region and thigh)	0.002	0.998	0.000
N64.5 Other signs and symptoms in breast	0.000	0.998	0.002
M84.01 Malunion of fracture (Shoulder region)	0.002	0.998	0.000
E20.8 Other hypoparathyroidism	0.000	0.998	0.002
N15 Other renal tubulo-interstitial diseases	0.000	0.998	0.002
N11.1 Chronic obstructive pyelonephritis	0.000	0.998	0.002
Q43 Other congenital malformations of intestine	0.002	0.998	0.000
C64-C68 Malignant neoplasms of urinary tract	0.002	0.998	0.000
M84.04 Malunion of fracture (Hand)	0.002	0.998	0.000
E20.9 Hypoparathyroidism, unspecified	0.000	0.998	0.002
E29.9 Testicular dysfunction, unspecified	0.000	0.998	0.002
H50.4 Other and unspecified heterotropia	0.002	0.998	0.000
O40 Polyhydramnios	0.002	0.998	0.000
E23.0 Hypopituitarism	0.000	0.998	0.002
H50.6 Mechanical strabismus	0.002	0.998	0.000
O34.5 Maternal care for other abnormalities of gravid uterus	0.002	0.998	0.000
O34.3 Maternal care for cervical incompetence	0.002	0.998	0.000
E28 Ovarian dysfunction	0.000	0.998	0.002
C49.6 Connective and soft tissue of trunk, unspecified	0.000	0.998	0.002
N16.5 Renal tubulo-interstitial disorders in transplant rejection	0.000	0.998	0.002
O34.1 Maternal care for tumour of corpus uteri	0.002	0.998	0.000
H04.9 Disorder of lachrymal system, unspecified	0.000	0.998	0.002
K35.3 Acute appendicitis with localized peritonitis	0.000	0.998	0.002
M84.19 Nonunion of fracture [pseudarthrosis] (Site unspecified)	0.002	0.998	0.000
M84.10 Nonunion of fracture [pseudarthrosis] (Multiple sites)	0.002	0.998	0.000
H50.8 Other specified strabismus	0.002	0.998	0.000
N14.1 Nephropathy induced by other drugs, medicaments and biological substances	0.000	0.998	0.002
C66 Malignant neoplasm of ureter	0.002	0.998	0.000
O46.9 Antepartum haemorrhage, unspecified	0.002	0.998	0.000
M84.09 Malunion of fracture (Site unspecified)	0.002	0.998	0.000
M84.00 Malunion of fracture (Multiple sites)	0.002	0.998	0.000
H25.0 Senile incipient cataract	0.002	0.998	0.000
N14.4 Toxic nephropathy, not elsewhere classified	0.000	0.998	0.002
N14.3 Nephropathy induced by heavy metals	0.000	0.998	0.002
N14.2 Nephropathy induced by unspecified drug, medicament or biological substance	0.000	0.998	0.002
N14.0 Analgesic nephropathy	0.000	0.998	0.002
N16.8 Renal tubulo-interstitial disorders in other diseases classified elsewhere	0.000	0.998	0.002
N16.4 Renal tubulo-interstitial disorders in systemic connective tissue disorders	0.000	0.998	0.002
N16.3 Renal tubulo-interstitial disorders in metabolic diseases	0.000	0.998	0.002
N16.2 Renal tubulo-interstitial disorders in blood diseases and disorders involving the immune mechanism	0.000	0.998	0.002
N16.1 Renal tubulo-interstitial disorders in neoplastic diseases	0.000	0.998	0.002
M84 Disorders of continuity of bone	0.002	0.998	0.000
S52.10 Fracture of upper end of radius (closed)	0.000	0.998	0.002
H90.6 Mixed conductive and sensorineural hearing loss, bilateral	0.002	0.998	0.000
N16.0 Renal tubulo-interstitial disorders in infectious and parasitic diseases classified elsewhere	0.000	0.998	0.002
O99.0 Anaemia complicating pregnancy, childbirth and the puerperium	0.002	0.998	0.000
M84.08 Malunion of fracture (Other)	0.002	0.998	0.000
S92.31 Fracture of metatarsal bone (open)	0.002	0.998	0.000
H50.1 Divergent concomitant strabismus	0.002	0.998	0.000
N12 Tubulo-interstitial nephritis, not specified as acute or chronic	0.000	0.998	0.002
H47.3 Other disorders of optic disk	0.000	0.998	0.002
H50.3 Intermittent heterotropia	0.002	0.998	0.000
H90.1 Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side	0.002	0.998	0.000
N99.9 Postprocedural disorder of genito-urinary system, unspecified	0.002	0.998	0.000
C49.2 Connective and soft tissue of lower limb, including hip	0.000	0.998	0.002
E29.1 Testicular hypofunction	0.000	0.998	0.002
N64.2 Atrophy of breast	0.000	0.998	0.002
Q43.3 Congenital malformations of intestinal fixation	0.002	0.998	0.000
O46 Antepartum haemorrhage, not elsewhere classified	0.002	0.998	0.000
M84.11 Nonunion of fracture [pseudarthrosis] (Shoulder region)	0.002	0.998	0.000
C02.9 Tongue, unspecified	0.000	0.998	0.002
C49.4 Connective and soft tissue of abdomen	0.000	0.998	0.002
N99.5 Malfunction of external stoma of urinary tract	0.002	0.998	0.000
O34.9 Maternal care for abnormality of pelvic organ, unspecified	0.002	0.998	0.000
O34.0 Maternal care for congenital malformation of uterus	0.002	0.998	0.000
M88.90 Paget's disease of bone, unspecified (Multiple sites)	0.002	0.998	0.000
H50.2 Vertical strabismus	0.002	0.998	0.000
N64.0 Fissure and fistula of nipple	0.000	0.998	0.002
O34.8 Maternal care for other abnormalities of pelvic organs	0.002	0.998	0.000
Z99.2 Dependence on renal dialysis	0.000	0.998	0.002
C49.8 Overlapping lesion of connective and soft tissue	0.000	0.998	0.002
F31.9 Bipolar affective disorder, unspecified	0.000	0.998	0.002
O34.6 Maternal care for abnormality of vagina	0.002	0.998	0.000
Q43.8 Other specified congenital malformations of intestine	0.002	0.998	0.000
B35.1 Tinea unguium	0.002	0.998	0.000
C44.1 Skin of eyelid, including canthus	0.000	0.998	0.002
O42 Premature rupture of membranes	0.002	0.998	0.000
H54.7 Unspecified visual loss	0.002	0.998	0.000
N15.8 Other specified renal tubulo-interstitial diseases	0.000	0.998	0.001
N15.1 Renal and perinephric abscess	0.000	0.998	0.001
N15.0 Balkan nephropathy	0.000	0.998	0.001
Q43.1 Hirschsprung's disease	0.002	0.998	0.000
Z49.0 Preparatory care for dialysis	0.000	0.998	0.002
C68 Malignant neoplasm of other and unspecified urinary organs	0.002	0.998	0.000
M84.17 Nonunion of fracture [pseudarthrosis] (Ankle and foot)	0.002	0.998	0.000
H54.9 Unspecified visual impairment (binocular)	0.002	0.998	0.000
Q43.9 Congenital malformation of intestine, unspecified	0.002	0.998	0.000
Q43.7 Persistent cloaca	0.002	0.998	0.000
Q43.6 Congenital fistula of rectum and anus	0.002	0.998	0.000
Q43.5 Ectopic anus	0.002	0.998	0.000
Q43.4 Duplication of intestine	0.002	0.998	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations