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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs15574
log Bayes Factor = 25.0908
Chromosome 6   position 31,686,497  (GRCh37) Explore rs15574 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E10.9 Without complications
1.000 0.000 0.000
K90.0 Coeliac disease
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
1.000 0.000 0.000
E10.3 With ophthalmic complications
0.995 0.005 0.000
E10.4 With neurological complications
0.993 0.007 0.000
J45.9 Asthma, unspecified
0.000 0.060 0.940
E10.1 With ketoacidosis
0.937 0.063 0.000
E10.2 With renal complications
0.928 0.072 0.000
E10.5 With peripheral circulatory complications
0.896 0.104 0.000
E10.0 With coma
0.887 0.113 0.000
E10.6 With other specified complications
0.725 0.275 0.000
E10.7 With multiple complications
0.717 0.283 0.000
E10.8 With unspecified complications
0.660 0.339 0.000
K50 Crohn's disease [regional enteritis]
0.656 0.344 0.000
K50.1 Crohn's disease of large intestine
0.646 0.354 0.000
K50-K52 Noninfective enteritis and colitis
0.634 0.366 0.000
K50.9 Crohn's disease, unspecified
0.632 0.368 0.000
D69.6 Thrombocytopenia, unspecified
0.000 0.392 0.608
K52 Other non-infective gastro-enteritis and colitis
0.607 0.393 0.000
K51 Ulcerative colitis
0.602 0.398 0.000
E10-E14 Diabetes mellitus
0.595 0.405 0.000
K52.8 Other specified non-infective gastro-enteritis and colitis
0.587 0.413 0.000
L43.9 Lichen planus, unspecified
0.582 0.418 0.000
K51.9 Ulcerative colitis, unspecified
0.572 0.428 0.000
L43 Lichen planus
0.568 0.432 0.000
K50.8 Other Crohn's disease
0.567 0.433 0.000
L40 Psoriasis
0.562 0.438 0.000
L40.5 Arthropathic psoriasis
0.561 0.439 0.000
K50.0 Crohn's disease of small intestine
0.561 0.439 0.000
L40-L45 Papulosquamous disorders
0.559 0.441 0.000
D69 Purpura and other haemorrhagic conditions
0.000 0.458 0.542
K52.3 Indeterminate colitis
0.520 0.480 0.000
D69.3 Idiopathic thrombocytopenic purpura
0.000 0.487 0.513
J45 Asthma
0.000 0.490 0.510
K52.0 Gastro-enteritis and colitis due to radiation
0.504 0.496 0.000
K51.2 Ulcerative (chronic) proctitis
0.492 0.508 0.000
E13 Other specified diabetes mellitus
0.491 0.509 0.000
K51.3 Ulcerative (chronic) rectosigmoiditis
0.490 0.510 0.000
E11 Non-insulin-dependent diabetes mellitus
0.485 0.515 0.000
K51.0 Ulcerative (chronic) enterocolitis
0.474 0.526 0.000
L40.9 Psoriasis, unspecified
0.472 0.528 0.000
E11.4 With neurological complications
0.462 0.538 0.000
K52.1 Toxic gastro-enteritis and colitis
0.461 0.539 0.000
K51.4 Pseudopolyposis of colon
0.456 0.544 0.000
L40.1 Generalised pustular psoriasis
0.447 0.553 0.000
L40.8 Other psoriasis
0.440 0.560 0.000
E11.0 With coma
0.440 0.560 0.000
J45.0 Predominantly allergic asthma
0.000 0.561 0.439
K52.2 Allergic and dietetic gastro-enteritis and colitis
0.435 0.564 0.000
D69.0 Allergic purpura
0.000 0.567 0.433
K51.1 Ulcerative (chronic) ileocolitis
0.432 0.568 0.000
E12 Malnutrition-related diabetes mellitus
0.426 0.574 0.000
L42 Pityriasis rosea
0.423 0.577 0.000
E13.9 Without complications
0.417 0.583 0.000
D69.5 Secondary thrombocytopenia
0.000 0.583 0.417
D69.4 Other primary thrombocytopenia
0.000 0.587 0.413
L43.8 Other lichen planus
0.410 0.590 0.000
L43.3 Subacute (active) lichen planus
0.408 0.592 0.000
L43.2 Lichenoid drug reaction
0.408 0.592 0.000
L43.1 Bullous lichen planus
0.408 0.592 0.000
L43.0 Hypertrophic lichen planus
0.408 0.592 0.000
L40.4 Guttate psoriasis
0.403 0.597 0.000
L40.3 Pustulosis palmaris et plantaris
0.403 0.597 0.000
L40.2 Acrodermatitis continua
0.403 0.597 0.000
E11.5 With peripheral circulatory complications
0.402 0.598 0.000
L44 Other papulosquamous disorders
0.401 0.599 0.000
L41 Parapsoriasis
0.401 0.599 0.000
L45 Papulosquamous disorders in diseases classified elsewhere
0.401 0.599 0.000
K51.5 Mucosal proctocolitis
0.392 0.608 0.000
D69.8 Other specified haemorrhagic conditions
0.000 0.611 0.388
D69.2 Other nonthrombocytopenic purpura
0.000 0.611 0.388
E14 Unspecified diabetes mellitus
0.386 0.614 0.000
E11.6 With other specified complications
0.384 0.616 0.000
D69.9 Haemorrhagic condition, unspecified
0.000 0.629 0.370
J45.1 Nonallergic asthma
0.000 0.634 0.366
L40.0 Psoriasis vulgaris
0.353 0.647 0.000
E13.8 With unspecified complications
0.352 0.648 0.000
E13.7 With multiple complications
0.352 0.648 0.000
E13.6 With other specified complications
0.352 0.648 0.000
E13.5 With peripheral circulatory complications
0.352 0.648 0.000
E13.4 With neurological complications
0.352 0.648 0.000
E13.3 With ophthalmic complications
0.352 0.648 0.000
E13.2 With renal complications
0.352 0.648 0.000
E13.1 With ketoacidosis
0.352 0.648 0.000
E13.0 With coma
0.352 0.648 0.000
E11.7 With multiple complications
0.348 0.652 0.000
J45.8 Mixed asthma
0.000 0.668 0.332
D69.1 Qualitative platelet defects
0.000 0.670 0.330
E11.1 With ketoacidosis
0.327 0.673 0.000
E14.8 With unspecified complications
0.327 0.673 0.000
E11.2 With renal complications
0.324 0.676 0.000
K90 Intestinal malabsorption
0.000 0.686 0.314
E12.9 Without complications
0.306 0.694 0.000
E12.8 With unspecified complications
0.306 0.694 0.000
E12.7 With multiple complications
0.306 0.694 0.000
E12.6 With other specified complications
0.306 0.694 0.000
E12.5 With peripheral circulatory complications
0.306 0.694 0.000
E12.4 With neurological complications
0.306 0.694 0.000
E12.3 With ophthalmic complications
0.306 0.694 0.000
E12.2 With renal complications
0.306 0.694 0.000
E12.1 With ketoacidosis
0.306 0.694 0.000
E12.0 With coma
0.306 0.694 0.000
E14.6 With other specified complications
0.303 0.697 0.000
E14.4 With neurological complications
0.301 0.699 0.000
L41.9 Parapsoriasis, unspecified
0.288 0.712 0.000
L41.8 Other parapsoriasis
0.288 0.712 0.000
L41.5 Retiform parapsoriasis
0.288 0.712 0.000
L41.4 Large plaque parapsoriasis
0.288 0.712 0.000
L41.3 Small plaque parapsoriasis
0.288 0.712 0.000
L41.2 Lymphomatoid papulosis
0.288 0.712 0.000
L41.1 Pityriasis lichenoides chronica
0.288 0.712 0.000
L41.0 Pityriasis lichenoides et varioliformis acuta
0.288 0.712 0.000
L44.9 Papulosquamous disorder, unspecified
0.288 0.712 0.000
L44.8 Other specified papulosquamous disorders
0.288 0.712 0.000
L44.4 Infantile papular acrodermatitis [Giannotti-Crosti]
0.288 0.712 0.000
L44.3 Lichen ruber moniliformis
0.288 0.712 0.000
L44.2 Lichen striatus
0.288 0.712 0.000
L44.1 Lichen nitidus
0.288 0.712 0.000
L44.0 Pityriasis rubra pilaris
0.288 0.712 0.000
E14.5 With peripheral circulatory complications
0.284 0.716 0.000
E14.2 Withrenal complications
0.284 0.716 0.000
E14.1 With ketoacidosis
0.284 0.716 0.000
E14.7 With multiple complications
0.277 0.723 0.000
E14.0 With coma
0.277 0.723 0.000
E11.8 With unspecified complications
0.267 0.733 0.000
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.744 0.255
E03.9 Hypothyroidism, unspecified
0.000 0.765 0.235
K51.8 Other ulcerative colitis
0.226 0.774 0.000
K90.3 Pancreatic steatorrhoea
0.000 0.774 0.225
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.774 0.225
K90.1 Tropical sprue
0.000 0.774 0.225
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.000 0.794 0.205
E14.3 With ophthalmic complications
0.205 0.795 0.000
K90.8 Other intestinal malabsorption
0.000 0.807 0.193
D80-D89 Certain disorders involving the immune mechanism
0.000 0.835 0.165
D86 Sarcoidosis
0.000 0.836 0.164
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.000 0.842 0.158
D65 Disseminated intravascular coagulation [defibrination syndrome]
0.000 0.844 0.156
D86.9 Sarcoidosis, unspecified
0.000 0.844 0.156
D80 Immunodeficiency with predominantly antibody defects
0.000 0.846 0.154
K90.9 Intestinal malabsorption, unspecified
0.000 0.850 0.150
D67 Hereditary factor IX deficiency
0.000 0.852 0.147
D86.0 Sarcoidosis of lung
0.000 0.854 0.146
D80.1 Nonfamilial hypogammaglobulinaemia
0.000 0.857 0.143
E03 Other hypothyroidism
0.001 0.863 0.136
D84 Other immunodeficiencies
0.000 0.867 0.133
D86.3 Sarcoidosis of skin
0.000 0.871 0.129
D86.1 Sarcoidosis of lymph nodes
0.000 0.873 0.127
D80.2 Selective deficiency of immunoglobulin A [IgA]
0.000 0.879 0.120
D83 Common variable immunodeficiency
0.000 0.880 0.119
D82 Immunodeficiency associated with other major defects
0.000 0.881 0.119
D81 Combined immunodeficiencies
0.000 0.881 0.119
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes
0.000 0.882 0.118
D89 Other disorders involving the immune mechanism, not elsewhere classified
0.000 0.885 0.115
D70-D77 Other diseases of blood and blood-forming organs
0.000 0.886 0.114
D80.9 Immunodeficiency with predominantly antibody defects, unspecified
0.000 0.889 0.110
D80.8 Other immunodeficiencies with predominantly antibody defects
0.000 0.889 0.110
D80.7 Transient hypogammaglobulinaemia of infancy
0.000 0.889 0.110
D80.6 Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinaemia
0.000 0.889 0.110
D80.5 Immunodeficiency with increased immunoglobulin M [IgM]
0.000 0.889 0.110
D80.4 Selective deficiency of immunoglobulin M [IgM]
0.000 0.889 0.110
D80.3 Selective deficiency of immunoglobulin G [IgG] subclasses
0.000 0.889 0.110
D80.0 Hereditary hypogammaglobulinaemia
0.000 0.889 0.110
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.001 0.890 0.110
D84.9 Immunodeficiency, unspecified
0.000 0.891 0.109
D86.8 Sarcoidosis of other and combined sites
0.000 0.892 0.108
D66 Hereditary factor VIII deficiency
0.000 0.895 0.105
E03.8 Other specified hypothyroidism
0.001 0.896 0.104
D73 Diseases of spleen
0.000 0.896 0.104
E03.5 Myxoedema coma
0.001 0.901 0.098
E03.4 Atrophy of thyroid (acquired)
0.001 0.901 0.098
E03.3 Postinfectious hypothyroidism
0.001 0.901 0.098
E03.1 Congenital hypothyroidism without goitre
0.001 0.901 0.098
E03.0 Congenital hypothyroidism with diffuse goitre
0.001 0.901 0.098
D84.8 Other specified immunodeficiencies
0.000 0.905 0.095
D84.1 Defects in the complement system
0.000 0.905 0.095
D84.0 Lymphocyte function antigen-1 [LFA-1] defect
0.000 0.905 0.095
E11.3 With ophthalmic complications
0.089 0.911 0.000
D73.0 Hyposplenism
0.000 0.913 0.087
D83.9 Common variable immunodeficiency, unspecified
0.000 0.913 0.087
D73.8 Other diseases of spleen
0.000 0.913 0.087
D83.8 Other common variable immunodeficiencies
0.000 0.914 0.086
D83.2 Common variable immunodeficiency with autoantibodies to B- or T-cells
0.000 0.914 0.086
D83.1 Common variable immunodeficiency with predominant immunoregulatory T-cell disorders
0.000 0.914 0.086
D83.0 Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
0.000 0.914 0.086
D81.9 Combined immunodeficiency, unspecified
0.000 0.915 0.085
D81.8 Other combined immunodeficiencies
0.000 0.915 0.085
D81.7 Major histocompatibility complex class II deficiency
0.000 0.915 0.085
D81.6 Major histocompatibility complex class I deficiency
0.000 0.915 0.085
D81.5 Purine nucleoside phosphorylase [PNP] deficiency
0.000 0.915 0.085
D81.4 Nezelof's syndrome
0.000 0.915 0.085
D81.3 Adenosine deaminase [ADA] deficiency
0.000 0.915 0.085
D81.2 Severe combined immunodeficiency [SCID] with low or normal B-cell numbers
0.000 0.915 0.085
D81.1 Severe combined immunodeficiency [SCID] with low T- and B-cell numbers
0.000 0.915 0.085
D81.0 Severe combined immunodeficiency [SCID] with reticular dysgenesis
0.000 0.915 0.085
D82.9 Immunodeficiency associated with major defect, unspecified
0.000 0.915 0.085
D82.8 Immunodeficiency associated with other specified major defects
0.000 0.915 0.085
D82.4 Hyperimmunoglobulin E [IgE] syndrome
0.000 0.915 0.085
D82.3 Immunodeficiency following hereditary defective response to Epstein-Barr virus
0.000 0.915 0.085
D82.2 Immunodeficiency with short-limbed stature
0.000 0.915 0.085
D82.1 Di George's syndrome
0.000 0.915 0.085
D82.0 Wiskott-Aldrich syndrome
0.000 0.915 0.085
D55-D59 Haemolytic anaemias
0.000 0.915 0.085
D73.5 Infarction of spleen
0.000 0.916 0.084
D89.0 Polyclonal hypergammaglobulinaemia
0.000 0.916 0.084
D89.9 Disorder involving the immune mechanism, unspecified
0.000 0.917 0.083
D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified
0.000 0.917 0.083
D89.3 Immune reconstitution syndrome
0.000 0.917 0.083
D89.1 Cryoglobulinaemia
0.000 0.917 0.083
D74 Methaemoglobinaemia
0.000 0.918 0.082
D77 Other disorders of blood and blood-forming organs in diseases classified elsewhere
0.000 0.918 0.082
D71 Functional disorders of polymorphonuclear neutrophils
0.000 0.918 0.082
D76 Certain diseases involving lymphoreticular tissue and reticulohistiocytic system
0.000 0.919 0.080
D89.2 Hypergammaglobulinaemia, unspecified
0.000 0.922 0.078
D75 Other diseases of blood and blood-forming organs
0.000 0.924 0.076
D72 Other disorders of white blood cells
0.000 0.924 0.076
D73.9 Disease of spleen, unspecified
0.000 0.925 0.074
D73.3 Abscess of spleen
0.000 0.925 0.074
D73.2 Chronic congestive splenomegaly
0.000 0.925 0.074
D73.1 Hypersplenism
0.000 0.925 0.074
D73.4 Cyst of spleen
0.000 0.930 0.069
D75.9 Disease of blood and blood-forming organs, unspecified
0.000 0.932 0.068
D57 Sickle-cell disorders
0.000 0.939 0.061
D55 Anaemia due to enzyme disorders
0.000 0.939 0.061
D59 Acquired haemolytic anaemia
0.000 0.940 0.060
D56 Thalassaemia
0.000 0.940 0.060
D74.9 Methaemoglobinaemia, unspecified
0.000 0.941 0.059
D74.8 Other methaemoglobinaemias
0.000 0.941 0.059
D74.0 Congenital methaemoglobinaemia
0.000 0.941 0.059
D75.2 Essential thrombocytosis
0.000 0.941 0.059
D76.2 Haemophagocytic syndrome, infection-associated
0.000 0.942 0.058
D76.1 Haemophagocytic lymphohistiocytosis
0.000 0.942 0.058
D76.0 Langerhans' cell histiocytosis, not elsewhere classified
0.000 0.942 0.058
D76.3 Other histiocytosis syndromes
0.000 0.943 0.056
D72.9 Disorder of white blood cells, unspecified
0.000 0.945 0.055
D72.0 Genetic anomalies of leukocytes
0.000 0.945 0.055
D72.8 Other specified disorders of white blood cells
0.000 0.948 0.052
D72.1 Eosinophilia
0.000 0.948 0.052
D70 Agranulocytosis
0.000 0.952 0.048
D75.8 Other specified diseases of blood and blood-forming organs
0.000 0.952 0.048
E14.9 Without complications
0.046 0.954 0.000
D50-D53 Nutritional anaemias
0.000 0.955 0.045
D55.9 Anaemia due to enzyme disorder, unspecified
0.000 0.956 0.044
D55.8 Other anaemias due to enzyme disorders
0.000 0.956 0.044
D55.3 Anaemia due to disorders of nucleotide metabolism
0.000 0.956 0.044
D55.2 Anaemia due to disorders of glycolytic enzymes
0.000 0.956 0.044
D55.1 Anaemia due to other disorders of glutathione metabolism
0.000 0.956 0.044
D55.0 Anaemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiency
0.000 0.956 0.044
D57.8 Other sickle-cell disorders
0.000 0.956 0.044
D57.3 Sickle-cell trait
0.000 0.956 0.044
D57.2 Double heterozygous sickling disorders
0.000 0.956 0.044
D57.1 Sickle-cell anaemia without crisis
0.000 0.956 0.044
D57.0 Sickle-cell anaemia with crisis
0.000 0.956 0.044
D59.1 Other autoimmune haemolytic anaemias
0.000 0.956 0.044
D75.0 Familial erythrocytosis
0.000 0.956 0.044
D59.8 Other acquired haemolytic anaemias
0.000 0.957 0.043
D59.6 Haemoglobinuria due to haemolysis from other external causes
0.000 0.957 0.043
D59.5 Paroxysmal nocturnal haemoglobinuria [Marchiafava-Micheli]
0.000 0.957 0.043
D59.4 Other nonautoimmune haemolytic anaemias
0.000 0.957 0.043
D59.3 Haemolytic-uraemic syndrome
0.000 0.957 0.043
D59.2 Drug-induced nonautoimmune haemolytic anaemia
0.000 0.957 0.043
D59.0 Drug-induced autoimmune haemolytic anaemia
0.000 0.957 0.043
D56.9 Thalassaemia, unspecified
0.000 0.957 0.043
D56.8 Other thalassaemias
0.000 0.957 0.043
D56.4 Hereditary persistence of foetal haemoglobin [HPFH]
0.000 0.957 0.043
D56.2 Delta-beta thalassaemia
0.000 0.957 0.043
D56.1 Beta thalassaemia
0.000 0.957 0.043
D56.0 Alpha thalassaemia
0.000 0.957 0.043
D56.3 Thalassaemia trait
0.000 0.958 0.042
D59.9 Acquired haemolytic anaemia, unspecified
0.000 0.959 0.041
D60-D64 Aplastic and other anaemias
0.000 0.960 0.040
D58 Other hereditary haemolytic anaemias
0.001 0.963 0.037
D75.1 Secondary polycythaemia
0.000 0.963 0.037
D53 Other nutritional anaemias
0.000 0.966 0.033
G35 Multiple sclerosis
0.000 0.969 0.031
D60 Acquired pure red cell aplasia [erythroblastopenia]
0.000 0.971 0.029
D52 Folate deficiency anaemia
0.000 0.972 0.028
D62 Acute posthaemorrhagic anaemia
0.000 0.973 0.027
D58.8 Other specified hereditary haemolytic anaemias
0.001 0.973 0.026
D58.1 Hereditary elliptocytosis
0.001 0.973 0.026
D58.2 Other haemoglobinopathies
0.001 0.974 0.025
D53.9 Nutritional anaemia, unspecified
0.000 0.975 0.025
D53.8 Other specified nutritional anaemias
0.000 0.976 0.024
D53.2 Scorbutic anaemia
0.000 0.976 0.024
D53.1 Other megaloblastic anaemias, not elsewhere classified
0.000 0.976 0.024
D53.0 Protein deficiency anaemia
0.000 0.976 0.024
Q61 Cystic kidney disease
0.024 0.976 0.000
Q61.0 Congenital single renal cyst
0.023 0.977 0.000
Q61.2 Polycystic kidney, adult type
0.022 0.978 0.000
T78.4 Allergy, unspecified
0.022 0.978 0.000
Q61.3 Polycystic kidney, unspecified
0.022 0.978 0.000
D63 Anaemia in chronic diseases classified elsewhere
0.000 0.978 0.022
D51 Vitamin B12 deficiency anaemia
0.000 0.978 0.022
T78 Adverse effects, not elsewhere classified
0.021 0.979 0.000
D60.9 Acquired pure red cell aplasia, unspecified
0.000 0.979 0.021
D60.8 Other acquired pure red cell aplasias
0.000 0.979 0.021
D60.1 Transient acquired pure red cell aplasia
0.000 0.979 0.021
D60.0 Chronic acquired pure red cell aplasia
0.000 0.979 0.021
T78.3 Angioneurotic oedema
0.021 0.979 0.000
D52.8 Other folate deficiency anaemias
0.000 0.980 0.020
D52.1 Drug-induced folate deficiency anaemia
0.000 0.980 0.020
D52.0 Dietary folate deficiency anaemia
0.000 0.980 0.020
D58.0 Hereditary spherocytosis
0.001 0.980 0.019
T78.0 Anaphylactic shock due to adverse food reaction
0.020 0.980 0.000
K90-K93 Other diseases of the digestive system
0.000 0.980 0.019
D58.9 Hereditary haemolytic anaemia, unspecified
0.001 0.981 0.018
Q61.4 Renal dysplasia
0.018 0.981 0.000
Q61.5 Medullary cystic kidney
0.018 0.982 0.000
E00-E07 Disorders of thyroid gland
0.004 0.982 0.014
D64 Other anaemias
0.000 0.983 0.017
Q61.8 Other cystic kidney diseases
0.017 0.983 0.000
Q61.1 Polycystic kidney, infantile type
0.017 0.983 0.000
D61 Other aplastic anaemias
0.000 0.983 0.017
T78.8 Other adverse effects, not elsewhere classified
0.016 0.984 0.000
Q61.9 Cystic kidney disease, unspecified
0.016 0.984 0.000
D63.0 Anaemia in neoplastic disease
0.000 0.984 0.016
D52.9 Folate deficiency anaemia, unspecified
0.000 0.984 0.016
D63.1 Anaemia in other chronic diseases classified elsewhere
0.000 0.984 0.016
D51.8 Other vitamin B12 deficiency anaemias
0.000 0.984 0.016
D51.3 Other dietary vitamin B12 deficiency anaemia
0.000 0.984 0.016
D51.2 Transcobalamin II deficiency
0.000 0.984 0.016
D51.1 Vitamin B12 deficiency anaemia due to selective vitamin B12 malabsorption with proteinuria
0.000 0.984 0.016
Q60-Q64 Congenital malformations of the urinary system
0.016 0.984 0.000
Q38.7 Pharyngeal pouch
0.016 0.984 0.000
T78.9 Adverse effect, unspecified
0.015 0.984 0.000
T78.1 Other adverse food reactions, not elsewhere classified
0.015 0.985 0.000
N21.0 Calculus in bladder
0.015 0.985 0.000
G63.2 Diabetic polyneuropathy
0.015 0.985 0.000
T78.2 Anaphylactic shock, unspecified
0.015 0.985 0.000
K93 Disorders of other digestive organs in diseases classified elsewhere
0.000 0.986 0.014
G61.0 Guillain-Barre syndrome
0.014 0.986 0.000
Q38 Other congenital malformations of tongue, mouth and pharynx
0.014 0.986 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.014 0.986 0.000
Q38-Q45 Other congenital malformations of the digestive system
0.013 0.986 0.000
D51.9 Vitamin B12 deficiency anaemia, unspecified
0.000 0.987 0.013
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.003 0.987 0.010
E00 Congenital iodine-deficiency syndrome
0.003 0.987 0.010
D64.8 Other specified anaemias
0.000 0.987 0.013
G61 Inflammatory polyneuropathy
0.013 0.987 0.000
E02 Subclinical iodine-deficiency hypothyroidism
0.003 0.987 0.010
D64.4 Congenital dyserythropoietic anaemia
0.000 0.987 0.013
D64.3 Other sideroblastic anaemias
0.000 0.987 0.013
D64.2 Secondary sideroblastic anaemia due to drugs and toxins
0.000 0.987 0.013
D64.1 Secondary sideroblastic anaemia due to disease
0.000 0.987 0.013
D64.0 Hereditary sideroblastic anaemia
0.000 0.987 0.013
D61.0 Constitutional aplastic anaemia
0.000 0.987 0.012
D61.8 Other specified aplastic anaemias
0.000 0.987 0.012
D61.3 Idiopathic aplastic anaemia
0.000 0.987 0.012
D61.2 Aplastic anaemia due to other external agents
0.000 0.987 0.012
Q20-Q28 Congenital malformations of the circulatory system
0.012 0.988 0.000
G63 Polyneuropathy in diseases classified elsewhere
0.012 0.988 0.000
Q80-Q89 Other congenital malformations
0.012 0.988 0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.012 0.988 0.000
E07 Other disorders of thyroid
0.005 0.989 0.007
Q35-Q37 Cleft lip and cleft palate
0.011 0.989 0.000
Q63 Other congenital malformations of kidney
0.011 0.989 0.000
Q85 Phakomatoses, not elsewhere classified
0.011 0.989 0.000
Q40 Other congenital malformations of upper alimentary tract
0.011 0.989 0.000
Q65 Congenital deformities of hip
0.011 0.989 0.000
G61.9 Inflammatory polyneuropathy, unspecified
0.011 0.989 0.000
K93.8 Disorders of other specified digestive organs in diseases classified elsewhere
0.000 0.989 0.010
K93.1 Megacolon in Chagas' disease
0.000 0.989 0.010
K93.0 Tuberculous disorders of intestines, peritoneum and mesenteric glands
0.000 0.989 0.010
Q27 Other congenital malformations of peripheral vascular system
0.011 0.989 0.000
Q38.8 Other congenital malformations of pharynx
0.010 0.989 0.000
Q38.6 Other congenital malformations of mouth
0.010 0.989 0.000
Q38.5 Congenital malformations of palate, not elsewhere classified
0.010 0.989 0.000
Q38.4 Congenital malformations of salivary glands and ducts
0.010 0.989 0.000
Q38.3 Other congenital malformations of tongue
0.010 0.989 0.000
Q38.2 Macroglossia
0.010 0.989 0.000
Q38.1 Ankyloglossia
0.010 0.989 0.000
Q38.0 Congenital malformations of lips, not elsewhere classified
0.010 0.989 0.000
Q83 Congenital malformations of breast
0.010 0.989 0.000
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system
0.010 0.989 0.000
D50 Iron deficiency anaemia
0.000 0.989 0.011
Q28 Other congenital malformations of circulatory system
0.010 0.989 0.000
M16.1 Other primary coxarthrosis
0.011 0.989 0.000
Q39 Congenital malformations of oesophagus
0.010 0.990 0.000
Q10-Q18 Congenital malformations of eye, ear, face and neck
0.010 0.990 0.000
D61.1 Drug-induced aplastic anaemia
0.000 0.990 0.010
Q30-Q34 Congenital malformations of the respiratory system
0.010 0.990 0.000
Q62 Congenital obstructive defects of renal pelvis and congenital malformations of ureter
0.010 0.990 0.000
Q64 Other congenital malformations of urinary system
0.010 0.990 0.000
G35-G37 Demyelinating diseases of the central nervous system
0.000 0.990 0.010
Q90-Q99 Chromosomal abnormalities, not elsewhere classified
0.010 0.990 0.000
Q45 Other congenital malformations of digestive system
0.010 0.990 0.000
Q42 Congenital absence, atresia and stenosis of large intestine
0.010 0.990 0.000
Q41 Congenital absence, atresia and stenosis of small intestine
0.010 0.990 0.000
Q85.0 Neurofibromatosis (nonmalignant)
0.010 0.990 0.000
E05 Thyrotoxicosis [hyperthyroidism]
0.001 0.990 0.009
J15.7 Pneumonia due to Mycoplasma pneumoniae
0.010 0.990 0.000
Q25 Congenital malformations of great arteries
0.010 0.990 0.000
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.002 0.990 0.007
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.002 0.990 0.007
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.002 0.990 0.007
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.002 0.990 0.007
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.002 0.990 0.007
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.002 0.990 0.007
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.002 0.990 0.007
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.002 0.990 0.007
G61.8 Other inflammatory polyneuropathies
0.010 0.990 0.000
Q65.2 Congenital dislocation of hip, unspecified
0.010 0.990 0.000
G61.1 Serum neuropathy
0.009 0.991 0.000
E04 Other non-toxic goitre
0.000 0.991 0.009
D51.0 Vitamin B12 deficiency anaemia due to intrinsic factor deficiency
0.000 0.991 0.009
N21 Calculus of lower urinary tract
0.009 0.991 0.000
Q65.8 Other congenital deformities of hip
0.009 0.991 0.000
Q27.3 Peripheral arteriovenous malformation
0.009 0.991 0.000
Q26 Congenital malformations of great veins
0.009 0.991 0.000
Q22 Congenital malformations of pulmonary and tricuspid valves
0.009 0.991 0.000
Q20 Congenital malformations of cardiac chambers and connexions
0.009 0.991 0.000
G63.8 Polyneuropathy in other diseases classified elsewhere
0.009 0.991 0.000
G63.6 Polyneuropathy in other musculoskeletal disorders
0.009 0.991 0.000
G63.5 Polyneuropathy in systemic connective tissue disorders
0.009 0.991 0.000
G63.4 Polyneuropathy in nutritional deficiency
0.009 0.991 0.000
G63.3 Polyneuropathy in other endocrine and metabolic diseases
0.009 0.991 0.000
G63.1 Polyneuropathy in neoplastic disease
0.009 0.991 0.000
G63.0 Polyneuropathy in infectious and parasitic diseases classified elsewhere
0.009 0.991 0.000
Q24 Other congenital malformations of heart
0.009 0.991 0.000
Q63.2 Ectopic kidney
0.009 0.991 0.000
Q40.3 Congenital malformation of stomach, unspecified
0.009 0.991 0.000
Q86 Congenital malformation syndromes due to known exogenous causes, not elsewhere classified
0.009 0.991 0.000
Q84 Other congenital malformations of integument
0.009 0.991 0.000
Q81 Epidermolysis bullosa
0.009 0.991 0.000
Q80 Congenital ichthyosis
0.009 0.991 0.000
Q60 Renal agenesis and other reduction defects of kidney
0.009 0.991 0.000
E06 Thyroiditis
0.004 0.991 0.005
Q37 Cleft palate with cleft lip
0.009 0.991 0.000
Q89 Other congenital malformations, not elsewhere classified
0.009 0.991 0.000
Q67 Congenital musculoskeletal deformities of head, face, spine and chest
0.009 0.991 0.000
Q00-Q07 Congenital malformations of the nervous system
0.009 0.991 0.000
Q23 Congenital malformations of aortic and mitral valves
0.009 0.991 0.000
Q85.8 Other phakomatoses, not elsewhere classified
0.009 0.991 0.000
T66-T78 Other and unspecified effects of external causes
0.009 0.991 0.000
Q28.3 Other malformations of cerebral vessels
0.009 0.991 0.000
Q83.3 Accessory nipple
0.009 0.991 0.000
Q77 Osteochondrodysplasia with defects of growth of tubular bones and spine
0.008 0.991 0.000
Q75 Other congenital malformations of skull and face bones
0.008 0.991 0.000
Q73 Reduction defects of unspecified limb
0.008 0.991 0.000
Q72 Reduction defects of lower limb
0.008 0.991 0.000
Q71 Reduction defects of upper limb
0.008 0.991 0.000
Q70 Syndactyly
0.008 0.991 0.000
Q69 Polydactyly
0.008 0.991 0.000
Q68 Other congenital musculoskeletal deformities
0.008 0.991 0.000
Q63.1 Lobulated, fused and horseshoe kidney
0.008 0.991 0.000
Q39.9 Congenital malformation of oesophagus, unspecified
0.008 0.991 0.000
Q83.1 Accessory breast
0.008 0.991 0.000
Q35 Cleft palate
0.008 0.991 0.000
Q74 Other congenital malformations of limb(s)
0.008 0.991 0.000
E07.1 Dyshormogenetic goitre
0.004 0.991 0.005
E07.0 Hypersecretion of calcitonin
0.004 0.991 0.005
Q66 Congenital deformities of feet
0.008 0.992 0.000
Q87 Other specified congenital malformation syndromes affecting multiple systems
0.008 0.992 0.000
Q10 Congenital malformations of eyelid, lachrymal apparatus and orbit
0.008 0.992 0.000
Q44 Congenital malformations of gallbladder, bile ducts and liver
0.008 0.992 0.000
Q78 Other osteochondrodysplasias
0.008 0.992 0.000
Q21 Congenital malformations of cardiac septa
0.008 0.992 0.000
Q36 Cleft lip
0.008 0.992 0.000
Q63.9 Congenital malformation of kidney, unspecified
0.008 0.992 0.000
Q63.8 Other specified congenital malformations of kidney
0.008 0.992 0.000
Q63.3 Hyperplastic and giant kidney
0.008 0.992 0.000
Q85.1 Tuberous sclerosis
0.008 0.992 0.000
Q28.0 Arteriovenous malformation of precerebral vessels
0.008 0.992 0.000
Q85.9 Phakomatosis, unspecified
0.008 0.992 0.000
Q11 Anophthalmos, microphthalmos and macrophthalmos
0.008 0.992 0.000
E07.8 Other specified disorders of thyroid
0.003 0.992 0.005
Q79 Congenital malformations of musculoskeletal system, not elsewhere classified
0.008 0.992 0.000
D50.0 Iron deficiency anaemia secondary to blood loss (chronic)
0.000 0.992 0.008
Q40.9 Congenital malformation of upper alimentary tract, unspecified
0.008 0.992 0.000
Q40.8 Other specified congenital malformations of upper alimentary tract
0.008 0.992 0.000
Q40.1 Congenital hiatus hernia
0.008 0.992 0.000
Q40.0 Congenital hypertrophic pyloric stenosis
0.008 0.992 0.000
Q17 Other congenital malformations of ear
0.008 0.992 0.000
Q28.2 Arteriovenous malformation of cerebral vessels
0.008 0.992 0.000
N21.1 Calculus in urethra
0.008 0.992 0.000
Q65.9 Congenital deformity of hip, unspecified
0.008 0.992 0.000
Q65.6 Unstable hip
0.008 0.992 0.000
Q65.5 Congenital subluxation of hip, unspecified
0.008 0.992 0.000
Q65.4 Congenital subluxation of hip, bilateral
0.008 0.992 0.000
Q65.3 Congenital subluxation of hip, unilateral
0.008 0.992 0.000
Q65.1 Congenital dislocation of hip, bilateral
0.008 0.992 0.000
Q65.0 Congenital dislocation of hip, unilateral
0.008 0.992 0.000
Q27.8 Other specified congenital malformations of peripheral vascular system
0.008 0.992 0.000
Q83.8 Other congenital malformations of breast
0.008 0.992 0.000
Q40.2 Other specified congenital malformations of stomach
0.008 0.992 0.000
Q25.6 Stenosis of pulmonary artery
0.008 0.992 0.000
Q64.7 Other congenital malformations of bladder and urethra
0.008 0.992 0.000
E04.9 Non-toxic goitre, unspecified
0.000 0.992 0.008
Q27.9 Congenital malformation of peripheral vascular system, unspecified
0.008 0.992 0.000
Q27.4 Congenital phlebectasia
0.008 0.992 0.000
Q27.2 Other congenital malformations of renal artery
0.008 0.992 0.000
Q27.1 Congenital renal artery stenosis
0.008 0.992 0.000
Q27.0 Congenital absence and hypoplasia of umbilical artery
0.008 0.992 0.000
G64 Other disorders of peripheral nervous system
0.008 0.992 0.000
E04.0 Non-toxic diffuse goitre
0.000 0.992 0.008
Q83.9 Congenital malformation of breast, unspecified
0.008 0.992 0.000
Q83.2 Absent nipple
0.008 0.992 0.000
Q83.0 Congenital absence of breast with absent nipple
0.008 0.992 0.000
D50.1 Sideropenic dysphagia
0.000 0.992 0.008
Q28.9 Congenital malformation of circulatory system, unspecified
0.008 0.992 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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