TreeWAS – Variant ID: rs1573646

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
E10.9 Without complications	0.000	0.000	1.000
E10.3 With ophthalmic complications	0.000	0.000	1.000
K90.0 Coeliac disease	0.000	0.000	1.000
E10 Insulin-dependent diabetes mellitus	0.000	0.000	1.000
G35 Multiple sclerosis	0.000	0.000	1.000
E10.1 With ketoacidosis	0.000	0.000	1.000
E05 Thyrotoxicosis [hyperthyroidism]	0.000	0.000	1.000
Chapter IV Endocrine, nutritional and metabolic diseases	0.000	0.000	1.000
E05.0 Thyrotoxicosis with diffuse goitre	0.000	0.000	1.000
E10-E14 Diabetes mellitus	0.000	0.000	1.000
E00-E07 Disorders of thyroid gland	0.000	0.001	0.999
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion	0.000	0.001	0.999
E16.2 Hypoglycaemia, unspecified	0.000	0.001	0.999
E16 Other disorders of pancreatic internal secretion	0.000	0.001	0.999
L40.9 Psoriasis, unspecified	0.998	0.002	0.000
E05.9 Thyrotoxicosis, unspecified	0.000	0.002	0.998
E10.2 With renal complications	0.000	0.006	0.994
E50-E64 Other nutritional deficiencies	0.000	0.038	0.962
E10.4 With neurological complications	0.000	0.045	0.955
E10.5 With peripheral circulatory complications	0.000	0.052	0.948
L40 Psoriasis	0.935	0.065	0.000
G35-G37 Demyelinating diseases of the central nervous system	0.000	0.067	0.933
E55 Vitamin D deficiency	0.000	0.078	0.922
G37 Other demyelinating diseases of central nervous system	0.000	0.088	0.912
D86.9 Sarcoidosis, unspecified	0.000	0.091	0.909
D86 Sarcoidosis	0.000	0.099	0.901
E14 Unspecified diabetes mellitus	0.000	0.102	0.898
E55.9 Vitamin D deficiency, unspecified	0.000	0.106	0.894
D86.0 Sarcoidosis of lung	0.000	0.123	0.877
M06.9 Rheumatoid arthritis, unspecified	0.860	0.140	0.000
L40.5 Arthropathic psoriasis	0.853	0.147	0.000
M06 Other rheumatoid arthritis	0.853	0.147	0.000
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)	0.851	0.149	0.000
G37.9 Demyelinating disease of central nervous system, unspecified	0.000	0.150	0.850
L40.0 Psoriasis vulgaris	0.825	0.174	0.000
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)	0.810	0.190	0.000
E16.0 Drug-induced hypoglycaemia without coma	0.000	0.191	0.809
M06.3 Rheumatoid nodule	0.808	0.192	0.000
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)	0.802	0.198	0.000
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system	0.000	0.210	0.790
E10.7 With multiple complications	0.000	0.212	0.788
E14.8 With unspecified complications	0.000	0.214	0.786
E40-E46 Malnutrition	0.000	0.215	0.785
D86.8 Sarcoidosis of other and combined sites	0.000	0.216	0.784
M05-M14 Inflammatory polyarthropathies	0.781	0.219	0.000
M05 Seropositive rheumatoid arthritis	0.781	0.219	0.000
M05.9 Seropositive rheumatoid arthritis, unspecified	0.781	0.219	0.000
M06.0 Seronegative rheumatoid arthritis	0.778	0.222	0.000
E14.3 With ophthalmic complications	0.000	0.225	0.775
G37.8 Other specified demyelinating diseases of central nervous system	0.000	0.226	0.774
E53 Deficiency of other B group vitamins	0.000	0.232	0.768
E10.0 With coma	0.000	0.240	0.760
D80-D89 Certain disorders involving the immune mechanism	0.000	0.240	0.760
E14.6 With other specified complications	0.000	0.249	0.751
M05.99 Seropositive rheumatoid arthritis, unspecified (Site unspecified)	0.748	0.252	0.000
E02 Subclinical iodine-deficiency hypothyroidism	0.000	0.261	0.739
E51 Thiamine deficiency	0.000	0.265	0.735
E10.8 With unspecified complications	0.000	0.273	0.727
D89 Other disorders involving the immune mechanism, not elsewhere classified	0.000	0.275	0.725
D86.1 Sarcoidosis of lymph nodes	0.000	0.277	0.723
E10.6 With other specified complications	0.000	0.277	0.722
E05.5 Thyroid crisis or storm	0.000	0.283	0.717
E05.4 Thyrotoxicosis factitia	0.000	0.283	0.717
E05.3 Thyrotoxicosis from ectopic thyroid tissue	0.000	0.283	0.717
E12 Malnutrition-related diabetes mellitus	0.000	0.283	0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions	0.000	0.283	0.716
E00 Congenital iodine-deficiency syndrome	0.000	0.283	0.716
E15 Nondiabetic hypoglycaemic coma	0.000	0.284	0.716
E16.9 Disorder of pancreatic internal secretion, unspecified	0.000	0.284	0.716
E16.8 Other specified disorders of pancreatic internal secretion	0.000	0.284	0.716
E16.4 Abnormal secretion of gastrin	0.000	0.284	0.716
E16.3 Increased secretion of glucagon	0.000	0.284	0.716
M06.93 Rheumatoid arthritis, unspecified (Forearm)	0.712	0.288	0.000
M06.98 Rheumatoid arthritis, unspecified (Other)	0.706	0.294	0.000
G36 Other acute disseminated demyelination	0.000	0.300	0.700
E61 Deficiency of other nutrient elements	0.000	0.301	0.699
E14.2 Withrenal complications	0.000	0.305	0.695
M06.32 Rheumatoid nodule (Upper arm)	0.692	0.308	0.000
E05.1 Thyrotoxicosis with toxic single thyroid nodule	0.000	0.310	0.690
L40.1 Generalised pustular psoriasis	0.690	0.310	0.000
E64 Sequelae of malnutrition and other nutritional deficiencies	0.000	0.310	0.690
E63 Other nutritional deficiencies	0.000	0.310	0.690
E50 Vitamin A deficiency	0.000	0.310	0.690
E60 Dietary zinc deficiency	0.000	0.310	0.690
E59 Dietary selenium deficiency	0.000	0.310	0.690
E54 Ascorbic acid deficiency	0.000	0.310	0.690
E52 Niacin deficiency [pellagra]	0.000	0.310	0.690
M05.90 Seropositive rheumatoid arthritis, unspecified (Multiple sites)	0.689	0.311	0.000
M06.34 Rheumatoid nodule (Hand)	0.689	0.311	0.000
E05.2 Thyrotoxicosis with toxic multinodular goitre	0.000	0.312	0.688
L40.4 Guttate psoriasis	0.684	0.316	0.000
L40.3 Pustulosis palmaris et plantaris	0.683	0.317	0.000
E56 Other vitamin deficiencies	0.000	0.320	0.680
D89.2 Hypergammaglobulinaemia, unspecified	0.000	0.321	0.679
M06.94 Rheumatoid arthritis, unspecified (Hand)	0.674	0.326	0.000
E13 Other specified diabetes mellitus	0.000	0.327	0.673
L40.2 Acrodermatitis continua	0.670	0.330	0.000
E55.0 Rickets, active	0.000	0.339	0.661
G37.5 Concentric sclerosis [Balo]	0.000	0.346	0.654
G37.4 Subacute necrotising myelitis	0.000	0.346	0.654
G37.2 Central pontine myelinolysis	0.000	0.346	0.654
G37.1 Central demyelination of corpus callosum	0.000	0.346	0.654
G37.0 Diffuse sclerosis	0.000	0.346	0.654
K90 Intestinal malabsorption	0.000	0.346	0.654
M06.33 Rheumatoid nodule (Forearm)	0.650	0.350	0.000
D89.9 Disorder involving the immune mechanism, unspecified	0.000	0.355	0.645
E14.7 With multiple complications	0.000	0.356	0.644
E14.0 With coma	0.000	0.356	0.644
E58 Dietary calcium deficiency	0.000	0.356	0.644
M06.07 Seronegative rheumatoid arthritis (Ankle and foot)	0.643	0.357	0.000
E04 Other non-toxic goitre	0.000	0.367	0.633
E46 Unspecified protein-energy malnutrition	0.000	0.370	0.630
M05.95 Seropositive rheumatoid arthritis, unspecified (Pelvic region and thigh)	0.629	0.371	0.000
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes	0.000	0.373	0.627
M06.36 Rheumatoid nodule (Lower leg)	0.625	0.375	0.000
E53.9 Vitamin B deficiency, unspecified	0.000	0.375	0.625
E14.5 With peripheral circulatory complications	0.000	0.379	0.621
M05.96 Seropositive rheumatoid arthritis, unspecified (Lower leg)	0.617	0.383	0.000
M14 Arthropathies in other diseases classified elsewhere	0.615	0.385	0.000
M06.00 Seronegative rheumatoid arthritis (Multiple sites)	0.615	0.385	0.000
M06.1 Adult-onset Still's disease	0.615	0.385	0.000
M05.94 Seropositive rheumatoid arthritis, unspecified (Hand)	0.614	0.385	0.000
M05.1 Rheumatoid lung disease	0.612	0.387	0.000
M06.2 Rheumatoid bursitis	0.611	0.388	0.000
M05.93 Seropositive rheumatoid arthritis, unspecified (Forearm)	0.609	0.390	0.000
M06.06 Seronegative rheumatoid arthritis (Lower leg)	0.609	0.391	0.000
L40-L45 Papulosquamous disorders	0.583	0.392	0.025
M05.91 Seropositive rheumatoid arthritis, unspecified (Shoulder region)	0.607	0.393	0.000
M06.01 Seronegative rheumatoid arthritis (Shoulder region)	0.606	0.394	0.000
E20-E35 Disorders of other endocrine glands	0.000	0.396	0.604
L40.8 Other psoriasis	0.602	0.398	0.000
M05.8 Other seropositive rheumatoid arthritis	0.598	0.402	0.000
M05.97 Seropositive rheumatoid arthritis, unspecified (Ankle and foot)	0.597	0.403	0.000
E27 Other disorders of adrenal gland	0.000	0.404	0.596
E27.1 Primary adrenocortical insufficiency	0.000	0.405	0.595
M05.92 Seropositive rheumatoid arthritis, unspecified (Upper arm)	0.593	0.407	0.000
E61.2 Magnesium deficiency	0.000	0.408	0.592
K90.9 Intestinal malabsorption, unspecified	0.000	0.410	0.590
D82 Immunodeficiency associated with other major defects	0.000	0.412	0.588
M06.30 Rheumatoid nodule (Multiple sites)	0.588	0.412	0.000
M08 Juvenile arthritis	0.587	0.413	0.000
M06.4 Inflammatory polyarthropathy	0.584	0.416	0.000
M06.39 Rheumatoid nodule (Site unspecified)	0.579	0.421	0.000
M06.38 Rheumatoid nodule (Other)	0.579	0.421	0.000
M06.35 Rheumatoid nodule (Pelvic region and thigh)	0.579	0.421	0.000
M06.31 Rheumatoid nodule (Shoulder region)	0.579	0.421	0.000
E14.9 Without complications	0.000	0.421	0.579
E14.1 With ketoacidosis	0.000	0.422	0.577
M06.09 Seronegative rheumatoid arthritis (Site unspecified)	0.576	0.424	0.000
M06.37 Rheumatoid nodule (Ankle and foot)	0.575	0.425	0.000
E06 Thyroiditis	0.000	0.425	0.575
E51.2 Wernicke's encephalopathy	0.000	0.428	0.572
M06.05 Seronegative rheumatoid arthritis (Pelvic region and thigh)	0.563	0.437	0.000
E44 Protein-energy malnutrition of moderate and mild degree	0.000	0.437	0.563
E45 Retarded development following protein-energy malnutrition	0.000	0.437	0.563
E43 Unspecified severe protein-energy malnutrition	0.000	0.437	0.563
E42 Marasmic kwashiorkor	0.000	0.437	0.563
E41 Nutritional marasmus	0.000	0.437	0.563
E40 Kwashiorkor	0.000	0.437	0.563
M09 Juvenile arthritis in diseases classified elsewhere	0.560	0.440	0.000
M05.3 Rheumatoid arthritis with involvement of other organs and systems	0.560	0.440	0.000
M05.0 Felty's syndrome	0.560	0.440	0.000
M05.98 Seropositive rheumatoid arthritis, unspecified (Other)	0.560	0.440	0.000
D89.0 Polyclonal hypergammaglobulinaemia	0.000	0.442	0.558
M06.08 Seronegative rheumatoid arthritis (Other)	0.558	0.442	0.000
M06.04 Seronegative rheumatoid arthritis (Hand)	0.558	0.442	0.000
M06.03 Seronegative rheumatoid arthritis (Forearm)	0.558	0.442	0.000
M06.02 Seronegative rheumatoid arthritis (Upper arm)	0.558	0.442	0.000
E53.8 Deficiency of other specified B group vitamins	0.000	0.443	0.557
M11 Other crystal arthropathies	0.556	0.444	0.000
M06.8 Other specified rheumatoid arthritis	0.555	0.445	0.000
E07 Other disorders of thyroid	0.000	0.447	0.553
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)	0.552	0.448	0.000
E04.2 Non-toxic multinodular goitre	0.000	0.448	0.552
E53.1 Pyridoxine deficiency	0.000	0.449	0.550
E53.0 Riboflavin deficiency	0.000	0.449	0.550
D86.3 Sarcoidosis of skin	0.000	0.451	0.548
D81 Combined immunodeficiencies	0.000	0.455	0.545
M05.2 Rheumatoid vasculitis	0.533	0.467	0.000
G36.0 Neuromyelitis optica [Devic]	0.000	0.467	0.533
E05.8 Other thyrotoxicosis	0.000	0.468	0.532
E51.9 Thiamine deficiency, unspecified	0.000	0.473	0.527
E51.8 Other manifestations of thiamine deficiency	0.000	0.473	0.527
E51.1 Beriberi	0.000	0.473	0.527
D80 Immunodeficiency with predominantly antibody defects	0.000	0.478	0.522
D89.3 Immune reconstitution syndrome	0.000	0.480	0.520
E12.9 Without complications	0.000	0.486	0.514
E12.8 With unspecified complications	0.000	0.486	0.514
E12.7 With multiple complications	0.000	0.486	0.514
E12.6 With other specified complications	0.000	0.486	0.514
E12.5 With peripheral circulatory complications	0.000	0.486	0.514
E12.4 With neurological complications	0.000	0.486	0.514
E12.3 With ophthalmic complications	0.000	0.486	0.514
E12.2 With renal complications	0.000	0.486	0.514
E12.1 With ketoacidosis	0.000	0.486	0.514
E12.0 With coma	0.000	0.486	0.514
E00.9 Congenital iodine-deficiency syndrome, unspecified	0.000	0.486	0.514
E00.2 Congenital iodine-deficiency syndrome, mixed type	0.000	0.486	0.514
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type	0.000	0.486	0.514
E00.0 Congenital iodine-deficiency syndrome, neurological type	0.000	0.486	0.514
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions	0.000	0.486	0.514
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified	0.000	0.486	0.514
E01.1 Iodine-deficiency-related multinodular (endemic) goitre	0.000	0.486	0.514
E01.0 Iodine-deficiency-related diffuse (endemic) goitre	0.000	0.486	0.514
M14.6 Neuropathic arthropathy	0.513	0.487	0.000
D83 Common variable immunodeficiency	0.000	0.490	0.510
M06.96 Rheumatoid arthritis, unspecified (Lower leg)	0.510	0.490	0.000
L42 Pityriasis rosea	0.490	0.498	0.012
G36.9 Acute disseminated demyelination, unspecified	0.000	0.498	0.502
G36.8 Other specified acute disseminated demyelination	0.000	0.498	0.502
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]	0.000	0.498	0.502
E61.9 Deficiency of nutrient element, unspecified	0.000	0.499	0.501
E61.8 Deficiency of other specified nutrient elements	0.000	0.499	0.501
E61.7 Deficiency of multiple nutrient elements	0.000	0.499	0.501
E61.6 Vanadium deficiency	0.000	0.499	0.501
E61.5 Molybdenum deficiency	0.000	0.499	0.501
E61.4 Chromium deficiency	0.000	0.499	0.501
E61.3 Manganese deficiency	0.000	0.499	0.501
E61.0 Copper deficiency	0.000	0.499	0.501
M06.92 Rheumatoid arthritis, unspecified (Upper arm)	0.500	0.500	0.000
E50.9 Vitamin A deficiency, unspecified	0.000	0.505	0.494
E50.8 Other manifestations of vitamin A deficiency	0.000	0.505	0.494
E50.7 Other ocular manifestations of vitamin A deficiency	0.000	0.505	0.494
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea	0.000	0.505	0.494
E50.5 Vitamin A deficiency with night blindness	0.000	0.505	0.494
E50.4 Vitamin A deficiency with keratomalacia	0.000	0.505	0.494
E50.3 Vitamin A deficiency with corneal ulceration and xerosis	0.000	0.505	0.494
E50.2 Vitamin A deficiency with corneal xerosis	0.000	0.505	0.494
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis	0.000	0.505	0.494
E50.0 Vitamin A deficiency with conjunctival xerosis	0.000	0.505	0.494
E63.9 Nutritional deficiency, unspecified	0.000	0.505	0.494
E63.8 Other specified nutritional deficiencies	0.000	0.505	0.494
E63.1 Imbalance of constituents of food intake	0.000	0.505	0.494
E63.0 Essential fatty acid [EFA] deficiency	0.000	0.505	0.494
E64.9 Sequelae of unspecified nutritional deficiency	0.000	0.505	0.494
E64.8 Sequelae of other nutritional deficiencies	0.000	0.505	0.494
E64.3 Sequelae of rickets	0.000	0.505	0.494
E64.2 Sequelae of vitamin C deficiency	0.000	0.505	0.494
E64.1 Sequelae of vitamin A deficiency	0.000	0.505	0.494
E64.0 Sequelae of protein-energy malnutrition	0.000	0.505	0.494
K90.4 Malabsorption due to intolerance, not elsewhere classified	0.000	0.505	0.494
M05.19 Rheumatoid lung disease (Site unspecified)	0.492	0.508	0.000
E56.9 Vitamin deficiency, unspecified	0.000	0.512	0.487
E56.8 Deficiency of other vitamins	0.000	0.512	0.487
E56.0 Deficiency of vitamin E	0.000	0.512	0.487
M07 Psoriatic and enteropathic arthropathies	0.484	0.516	0.000
E04.0 Non-toxic diffuse goitre	0.000	0.516	0.484
E27.2 Addisonian crisis	0.000	0.516	0.484
E13.9 Without complications	0.000	0.516	0.484
E13.8 With unspecified complications	0.000	0.518	0.482
E13.7 With multiple complications	0.000	0.518	0.482
E13.6 With other specified complications	0.000	0.518	0.482
E13.5 With peripheral circulatory complications	0.000	0.518	0.482
E13.4 With neurological complications	0.000	0.518	0.482
E13.2 With renal complications	0.000	0.518	0.482
E13.1 With ketoacidosis	0.000	0.518	0.482
E13.0 With coma	0.000	0.518	0.482
D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified	0.000	0.521	0.478
E56.1 Deficiency of vitamin K	0.000	0.522	0.477
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)	0.477	0.522	0.000
E14.4 With neurological complications	0.000	0.524	0.476
E20 Hypoparathyroidism	0.000	0.528	0.472
M12 Other specific arthropathies	0.470	0.529	0.000
E27.8 Other specified disorders of adrenal gland	0.000	0.531	0.469
K90.3 Pancreatic steatorrhoea	0.000	0.531	0.469
K90.2 Blind loop syndrome, not elsewhere classified	0.000	0.531	0.469
K90.1 Tropical sprue	0.000	0.531	0.469
M05.80 Other seropositive rheumatoid arthritis (Multiple sites)	0.465	0.535	0.000
D82.1 Di George's syndrome	0.000	0.535	0.465
L44 Other papulosquamous disorders	0.446	0.537	0.017
E16.1 Other hypoglycaemia	0.001	0.543	0.457
E04.8 Other specified non-toxic goitre	0.000	0.546	0.454
E34 Other endocrine disorders	0.000	0.549	0.451
M08.0 Juvenile rheumatoid arthritis	0.448	0.552	0.000
D84 Other immunodeficiencies	0.000	0.555	0.445
M06.10 Adult-onset Still's disease (Multiple sites)	0.444	0.556	0.000
E31 Polyglandular dysfunction	0.000	0.557	0.443
M14.8 Arthropathies in other specified diseases classified elsewhere	0.441	0.559	0.000
M14.5 Arthropathies in other endocrine, nutritional and metabolic disorders	0.441	0.559	0.000
M14.4 Arthropathy in amyloidosis	0.441	0.559	0.000
M14.3 Lipoid dermatoarthritis	0.441	0.559	0.000
M14.1 Crystal arthropathy in other metabolic disorders	0.441	0.559	0.000
M14.0 Gouty arthropathy due to enzyme defects and other inherited disorders	0.441	0.559	0.000
M06.19 Adult-onset Still's disease (Site unspecified)	0.441	0.559	0.000
M06.18 Adult-onset Still's disease (Other)	0.441	0.559	0.000
M06.17 Adult-onset Still's disease (Ankle and foot)	0.441	0.559	0.000
M06.16 Adult-onset Still's disease (Lower leg)	0.441	0.559	0.000
M06.15 Adult-onset Still's disease (Pelvic region and thigh)	0.441	0.559	0.000
M06.14 Adult-onset Still's disease (Hand)	0.441	0.559	0.000
M06.13 Adult-onset Still's disease (Forearm)	0.441	0.559	0.000
M06.12 Adult-onset Still's disease (Upper arm)	0.441	0.559	0.000
M06.11 Adult-onset Still's disease (Shoulder region)	0.441	0.559	0.000
M06.46 Inflammatory polyarthropathy (Lower leg)	0.440	0.560	0.000
M05.18 Rheumatoid lung disease (Other)	0.439	0.561	0.000
M05.17 Rheumatoid lung disease (Ankle and foot)	0.439	0.561	0.000
M05.16 Rheumatoid lung disease (Lower leg)	0.439	0.561	0.000
M05.15 Rheumatoid lung disease (Pelvic region and thigh)	0.439	0.561	0.000
M05.14 Rheumatoid lung disease (Hand)	0.439	0.561	0.000
M05.13 Rheumatoid lung disease (Forearm)	0.439	0.561	0.000
M05.12 Rheumatoid lung disease (Upper arm)	0.439	0.561	0.000
M05.11 Rheumatoid lung disease (Shoulder region)	0.439	0.561	0.000
M05.10 Rheumatoid lung disease (Multiple sites)	0.439	0.561	0.000
M06.29 Rheumatoid bursitis (Site unspecified)	0.438	0.561	0.000
M06.28 Rheumatoid bursitis (Other)	0.438	0.561	0.000
M06.27 Rheumatoid bursitis (Ankle and foot)	0.438	0.561	0.000
M06.26 Rheumatoid bursitis (Lower leg)	0.438	0.561	0.000
M06.25 Rheumatoid bursitis (Pelvic region and thigh)	0.438	0.561	0.000
M06.24 Rheumatoid bursitis (Hand)	0.438	0.561	0.000
M06.23 Rheumatoid bursitis (Forearm)	0.438	0.561	0.000
M06.22 Rheumatoid bursitis (Upper arm)	0.438	0.561	0.000
M06.21 Rheumatoid bursitis (Shoulder region)	0.438	0.561	0.000
M06.20 Rheumatoid bursitis (Multiple sites)	0.438	0.561	0.000
E13.3 With ophthalmic complications	0.000	0.564	0.436
M11.9 Crystal arthropathy, unspecified	0.436	0.564	0.000
L41 Parapsoriasis	0.418	0.564	0.018
L45 Papulosquamous disorders in diseases classified elsewhere	0.418	0.564	0.018
E06.5 Other chronic thyroiditis	0.000	0.564	0.436
E35 Disorders of endocrine glands in diseases classified elsewhere	0.000	0.567	0.433
E32 Diseases of thymus	0.000	0.567	0.433
E30 Disorders of puberty, not elsewhere classified	0.000	0.567	0.433
D89.1 Cryoglobulinaemia	0.000	0.567	0.433
M05.89 Other seropositive rheumatoid arthritis (Site unspecified)	0.430	0.570	0.000
M05.88 Other seropositive rheumatoid arthritis (Other)	0.429	0.571	0.000
M05.87 Other seropositive rheumatoid arthritis (Ankle and foot)	0.429	0.571	0.000
M05.86 Other seropositive rheumatoid arthritis (Lower leg)	0.429	0.571	0.000
M05.85 Other seropositive rheumatoid arthritis (Pelvic region and thigh)	0.429	0.571	0.000
M05.84 Other seropositive rheumatoid arthritis (Hand)	0.429	0.571	0.000
M05.83 Other seropositive rheumatoid arthritis (Forearm)	0.429	0.571	0.000
M05.82 Other seropositive rheumatoid arthritis (Upper arm)	0.429	0.571	0.000
M05.81 Other seropositive rheumatoid arthritis (Shoulder region)	0.429	0.571	0.000
E27.5 Adrenomedullary hyperfunction	0.000	0.572	0.428
E27.0 Other adrenocortical overactivity	0.000	0.572	0.428
D80.1 Nonfamilial hypogammaglobulinaemia	0.000	0.577	0.423
E27.3 Drug-induced adrenocortical insufficiency	0.000	0.578	0.422
D82.9 Immunodeficiency associated with major defect, unspecified	0.000	0.578	0.422
D82.8 Immunodeficiency associated with other specified major defects	0.000	0.578	0.422
D82.4 Hyperimmunoglobulin E [IgE] syndrome	0.000	0.578	0.422
D82.3 Immunodeficiency following hereditary defective response to Epstein-Barr virus	0.000	0.578	0.422
D82.2 Immunodeficiency with short-limbed stature	0.000	0.578	0.422
D82.0 Wiskott-Aldrich syndrome	0.000	0.578	0.422
M08.9 Juvenile arthritis, unspecified	0.421	0.579	0.000
M08.8 Other juvenile arthritis	0.421	0.579	0.000
M08.4 Pauciarticular juvenile arthritis	0.421	0.579	0.000
M08.3 Juvenile polyarthritis (seronegative)	0.421	0.579	0.000
M08.2 Juvenile arthritis with systemic onset	0.421	0.579	0.000
M08.1 Juvenile ankylosing spondylitis	0.421	0.579	0.000
M06.49 Inflammatory polyarthropathy (Site unspecified)	0.420	0.579	0.000
M06.48 Inflammatory polyarthropathy (Other)	0.419	0.581	0.000
M06.47 Inflammatory polyarthropathy (Ankle and foot)	0.419	0.581	0.000
M06.45 Inflammatory polyarthropathy (Pelvic region and thigh)	0.419	0.581	0.000
M06.44 Inflammatory polyarthropathy (Hand)	0.419	0.581	0.000
M06.43 Inflammatory polyarthropathy (Forearm)	0.419	0.581	0.000
M06.42 Inflammatory polyarthropathy (Upper arm)	0.419	0.581	0.000
M06.41 Inflammatory polyarthropathy (Shoulder region)	0.419	0.581	0.000
E28 Ovarian dysfunction	0.000	0.584	0.415
M14.2 Diabetic arthropathy	0.413	0.586	0.000
E06.4 Drug-induced thyroiditis	0.000	0.588	0.412
E06.2 Chronic thyroiditis with transient thyrotoxicosis	0.000	0.588	0.412
E06.0 Acute thyroiditis	0.000	0.588	0.412
E06.1 Subacute thyroiditis	0.000	0.590	0.410
E44.1 Mild protein-energy malnutrition	0.000	0.596	0.403
E44.0 Moderate protein-energy malnutrition	0.000	0.596	0.403
M06.89 Other specified rheumatoid arthritis (Site unspecified)	0.402	0.598	0.000
M09.8 Juvenile arthritis in other diseases classified elsewhere	0.401	0.598	0.000
M09.2 Juvenile arthritis in ulcerative colitis	0.401	0.598	0.000
M09.1 Juvenile arthritis in Crohn's disease [regional enteritis]	0.401	0.598	0.000
M09.0 Juvenile arthritis in psoriasis	0.401	0.598	0.000
M05.09 Felty's syndrome (Site unspecified)	0.401	0.598	0.000
M05.08 Felty's syndrome (Other)	0.401	0.598	0.000
M05.07 Felty's syndrome (Ankle and foot)	0.401	0.598	0.000
M05.06 Felty's syndrome (Lower leg)	0.401	0.598	0.000
M05.05 Felty's syndrome (Pelvic region and thigh)	0.401	0.598	0.000
M05.04 Felty's syndrome (Hand)	0.401	0.598	0.000
M05.03 Felty's syndrome (Forearm)	0.401	0.598	0.000
M05.02 Felty's syndrome (Upper arm)	0.401	0.598	0.000
M05.01 Felty's syndrome (Shoulder region)	0.401	0.598	0.000
M05.00 Felty's syndrome (Multiple sites)	0.401	0.598	0.000
M05.39 Rheumatoid arthritis with involvement of other organs and systems (Site unspecified)	0.401	0.598	0.000
M05.38 Rheumatoid arthritis with involvement of other organs and systems (Other)	0.401	0.598	0.000
M05.37 Rheumatoid arthritis with involvement of other organs and systems (Ankle and foot)	0.401	0.598	0.000
M05.36 Rheumatoid arthritis with involvement of other organs and systems (Lower leg)	0.401	0.598	0.000
M05.35 Rheumatoid arthritis with involvement of other organs and systems (Pelvic region and thigh)	0.401	0.598	0.000
M05.34 Rheumatoid arthritis with involvement of other organs and systems (Hand)	0.401	0.598	0.000
M05.33 Rheumatoid arthritis with involvement of other organs and systems (Forearm)	0.401	0.598	0.000
M05.32 Rheumatoid arthritis with involvement of other organs and systems (Upper arm)	0.401	0.598	0.000
M05.31 Rheumatoid arthritis with involvement of other organs and systems (Shoulder region)	0.401	0.598	0.000
M05.30 Rheumatoid arthritis with involvement of other organs and systems (Multiple sites)	0.401	0.598	0.000
E06.9 Thyroiditis, unspecified	0.000	0.600	0.400
L43 Lichen planus	0.390	0.600	0.010
M11.1 Familial chondrocalcinosis	0.399	0.601	0.000
M11.0 Hydroxyapatite deposition disease	0.399	0.601	0.000
M13 Other arthritis	0.398	0.602	0.000
M06.88 Other specified rheumatoid arthritis (Other)	0.398	0.602	0.000
M06.87 Other specified rheumatoid arthritis (Ankle and foot)	0.398	0.602	0.000
M06.86 Other specified rheumatoid arthritis (Lower leg)	0.398	0.602	0.000
M06.85 Other specified rheumatoid arthritis (Pelvic region and thigh)	0.398	0.602	0.000
M06.84 Other specified rheumatoid arthritis (Hand)	0.398	0.602	0.000
M06.83 Other specified rheumatoid arthritis (Forearm)	0.398	0.602	0.000
M06.82 Other specified rheumatoid arthritis (Upper arm)	0.398	0.602	0.000
M06.81 Other specified rheumatoid arthritis (Shoulder region)	0.398	0.602	0.000
C21.0 Anus, unspecified	0.397	0.603	0.000
E07.1 Dyshormogenetic goitre	0.000	0.603	0.397
E07.0 Hypersecretion of calcitonin	0.000	0.603	0.397
H36.0 Diabetic retinopathy	0.000	0.607	0.393
K90.8 Other intestinal malabsorption	0.000	0.607	0.393
D81.9 Combined immunodeficiency, unspecified	0.000	0.609	0.391
D81.8 Other combined immunodeficiencies	0.000	0.609	0.391
D81.7 Major histocompatibility complex class II deficiency	0.000	0.609	0.391
D81.6 Major histocompatibility complex class I deficiency	0.000	0.609	0.391
D81.5 Purine nucleoside phosphorylase [PNP] deficiency	0.000	0.609	0.391
D81.4 Nezelof's syndrome	0.000	0.609	0.391
D81.3 Adenosine deaminase [ADA] deficiency	0.000	0.609	0.391
D81.2 Severe combined immunodeficiency [SCID] with low or normal B-cell numbers	0.000	0.609	0.391
D81.1 Severe combined immunodeficiency [SCID] with low T- and B-cell numbers	0.000	0.609	0.391
D81.0 Severe combined immunodeficiency [SCID] with reticular dysgenesis	0.000	0.609	0.391
E34.8 Other specified endocrine disorders	0.000	0.609	0.391
C21.1 Anal canal	0.389	0.611	0.000
C21 Malignant neoplasm of anus and anal canal	0.387	0.613	0.000
D80.2 Selective deficiency of immunoglobulin A [IgA]	0.000	0.617	0.383
M05.28 Rheumatoid vasculitis (Other)	0.382	0.618	0.000
M05.27 Rheumatoid vasculitis (Ankle and foot)	0.382	0.618	0.000
M05.26 Rheumatoid vasculitis (Lower leg)	0.382	0.618	0.000
M05.25 Rheumatoid vasculitis (Pelvic region and thigh)	0.382	0.618	0.000
M05.24 Rheumatoid vasculitis (Hand)	0.382	0.618	0.000
M05.23 Rheumatoid vasculitis (Forearm)	0.382	0.618	0.000
M05.22 Rheumatoid vasculitis (Upper arm)	0.382	0.618	0.000
M05.21 Rheumatoid vasculitis (Shoulder region)	0.382	0.618	0.000
E04.9 Non-toxic goitre, unspecified	0.000	0.618	0.382
M11.8 Other specified crystal arthropathies	0.380	0.619	0.000
E20.9 Hypoparathyroidism, unspecified	0.000	0.622	0.378
D80.3 Selective deficiency of immunoglobulin G [IgG] subclasses	0.000	0.625	0.374
D80.8 Other immunodeficiencies with predominantly antibody defects	0.000	0.626	0.374
D80.7 Transient hypogammaglobulinaemia of infancy	0.000	0.626	0.374
D80.6 Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinaemia	0.000	0.626	0.374
D80.5 Immunodeficiency with increased immunoglobulin M [IgM]	0.000	0.626	0.374
D80.0 Hereditary hypogammaglobulinaemia	0.000	0.626	0.374
M05.29 Rheumatoid vasculitis (Site unspecified)	0.369	0.630	0.000
E07.8 Other specified disorders of thyroid	0.000	0.631	0.369
M05.20 Rheumatoid vasculitis (Multiple sites)	0.369	0.631	0.000
M11.2 Other chondrocalcinosis	0.366	0.634	0.000
D83.8 Other common variable immunodeficiencies	0.000	0.634	0.366
D83.2 Common variable immunodeficiency with autoantibodies to B- or T-cells	0.000	0.634	0.366
D83.1 Common variable immunodeficiency with predominant immunoregulatory T-cell disorders	0.000	0.634	0.366
D83.0 Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function	0.000	0.634	0.366
E25 Adrenogenital disorders	0.000	0.637	0.362
M06.40 Inflammatory polyarthropathy (Multiple sites)	0.361	0.639	0.000
E26 Hyperaldosteronism	0.000	0.640	0.360
L44.0 Pityriasis rubra pilaris	0.349	0.641	0.010
E23 Hypofunction and other disorders of pituitary gland	0.000	0.644	0.356
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	0.000	0.645	0.355
M11.96 Crystal arthropathy, unspecified (Lower leg)	0.350	0.650	0.000
E61.1 Iron deficiency	0.000	0.650	0.350
E24 Cushing's syndrome	0.000	0.651	0.349
M08.00 Juvenile rheumatoid arthritis (Multiple sites)	0.349	0.651	0.000
H36 Retinal disorders in diseases classified elsewhere	0.000	0.651	0.349
E27.9 Disorder of adrenal gland, unspecified	0.000	0.653	0.347
M07.5 Arthropathy in ulcerative colitis	0.347	0.653	0.000
M07.4 Arthropathy in Crohn's disease [regional enteritis]	0.347	0.653	0.000
M07.2 Psoriatic spondylitis	0.347	0.653	0.000
M07.1 Arthritis mutilans	0.347	0.653	0.000
M07.0 Distal interphalangeal psoriatic arthropathy	0.347	0.653	0.000
D80.4 Selective deficiency of immunoglobulin M [IgM]	0.000	0.660	0.339
E20.8 Other hypoparathyroidism	0.000	0.661	0.339
E20.1 Pseudohypoparathyroidism	0.000	0.661	0.339
E20.0 Idiopathic hypoparathyroidism	0.000	0.661	0.339
M12.4 Intermittent hydrarthrosis	0.337	0.662	0.000
M12.1 Kaschin-Beck disease	0.337	0.662	0.000
M12.0 Chronic postrheumatic arthropathy [Jaccoud]	0.337	0.662	0.000
M06.80 Other specified rheumatoid arthritis (Multiple sites)	0.335	0.665	0.000
L44.9 Papulosquamous disorder, unspecified	0.320	0.668	0.012
L44.8 Other specified papulosquamous disorders	0.320	0.668	0.012
L44.4 Infantile papular acrodermatitis [Giannotti-Crosti]	0.320	0.668	0.012
L44.3 Lichen ruber moniliformis	0.320	0.668	0.012
L44.2 Lichen striatus	0.320	0.668	0.012
L44.1 Lichen nitidus	0.320	0.668	0.012
M12.5 Traumatic arthropathy	0.332	0.668	0.000
M07.6 Other enteropathic arthropathies	0.331	0.668	0.000
D83.9 Common variable immunodeficiency, unspecified	0.000	0.669	0.331
E28.3 Primary ovarian failure	0.000	0.670	0.330
E31.0 Autoimmune polyglandular failure	0.000	0.673	0.327
M13.8 Other specified arthritis	0.323	0.677	0.000
E34.5 Androgen resistance syndrome	0.000	0.677	0.323
E34.4 Constitutional tall stature	0.000	0.677	0.323
E34.2 Ectopic hormone secretion, not elsewhere classified	0.000	0.677	0.323
E34.1 Other hypersecretion of intestinal hormones	0.000	0.677	0.323
M08.09 Juvenile rheumatoid arthritis (Site unspecified)	0.321	0.678	0.000
M08.08 Juvenile rheumatoid arthritis (Other)	0.321	0.678	0.000
M08.07 Juvenile rheumatoid arthritis (Ankle and foot)	0.321	0.678	0.000
M08.06 Juvenile rheumatoid arthritis (Lower leg)	0.321	0.678	0.000
M08.05 Juvenile rheumatoid arthritis (Pelvic region and thigh)	0.321	0.678	0.000
M08.04 Juvenile rheumatoid arthritis (Hand)	0.321	0.678	0.000
M08.03 Juvenile rheumatoid arthritis (Forearm)	0.321	0.678	0.000
M08.02 Juvenile rheumatoid arthritis (Upper arm)	0.321	0.678	0.000
M08.01 Juvenile rheumatoid arthritis (Shoulder region)	0.321	0.678	0.000
E65-E68 Obesity and other hyperalimentation	0.000	0.679	0.321
M12.8 Other specific arthropathies, not elsewhere classified	0.320	0.679	0.000
D84.0 Lymphocyte function antigen-1 [LFA-1] defect	0.000	0.681	0.319
E31.9 Polyglandular dysfunction, unspecified	0.000	0.682	0.317
E31.8 Other polyglandular dysfunction	0.000	0.682	0.317
E31.1 Polyglandular hyperfunction	0.000	0.682	0.317

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations