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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs1573649
log Bayes Factor = 104.51
Chromosome 6   position 32,731,258  (GRCh37) Explore rs1573649 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E10.9 Without complications
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.000 1.000
K90.0 Coeliac disease
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
G35 Multiple sclerosis
0.000 0.000 1.000
E10.1 With ketoacidosis
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.000 1.000
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.001 0.999
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.001 0.999
E16.2 Hypoglycaemia, unspecified
0.000 0.001 0.999
E16 Other disorders of pancreatic internal secretion
0.000 0.001 0.999
L40.9 Psoriasis, unspecified
0.998 0.002 0.000
E05.9 Thyrotoxicosis, unspecified
0.000 0.003 0.997
E10.2 With renal complications
0.000 0.006 0.994
E10.4 With neurological complications
0.000 0.046 0.954
E10.5 With peripheral circulatory complications
0.000 0.052 0.948
E50-E64 Other nutritional deficiencies
0.000 0.053 0.947
G35-G37 Demyelinating diseases of the central nervous system
0.000 0.061 0.939
L40 Psoriasis
0.934 0.066 0.000
G37 Other demyelinating diseases of central nervous system
0.000 0.083 0.917
D86.9 Sarcoidosis, unspecified
0.000 0.091 0.909
E55 Vitamin D deficiency
0.000 0.093 0.907
D86 Sarcoidosis
0.000 0.099 0.901
E14 Unspecified diabetes mellitus
0.000 0.100 0.900
E55.9 Vitamin D deficiency, unspecified
0.000 0.122 0.878
D86.0 Sarcoidosis of lung
0.000 0.123 0.877
G37.9 Demyelinating disease of central nervous system, unspecified
0.000 0.145 0.855
L40.5 Arthropathic psoriasis
0.847 0.153 0.000
L40.0 Psoriasis vulgaris
0.826 0.174 0.000
M06.9 Rheumatoid arthritis, unspecified
0.825 0.175 0.000
M06 Other rheumatoid arthritis
0.819 0.181 0.000
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.815 0.185 0.000
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.191 0.809
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.000 0.206 0.794
E10.7 With multiple complications
0.000 0.212 0.788
E14.8 With unspecified complications
0.000 0.212 0.788
D86.8 Sarcoidosis of other and combined sites
0.000 0.217 0.783
E40-E46 Malnutrition
0.000 0.217 0.783
G37.8 Other specified demyelinating diseases of central nervous system
0.000 0.222 0.778
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.777 0.223 0.000
M06.3 Rheumatoid nodule
0.776 0.224 0.000
E14.3 With ophthalmic complications
0.000 0.225 0.775
D80-D89 Certain disorders involving the immune mechanism
0.000 0.230 0.770
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.762 0.238 0.000
E10.0 With coma
0.000 0.240 0.760
E14.6 With other specified complications
0.000 0.248 0.752
M06.0 Seronegative rheumatoid arthritis
0.748 0.252 0.000
M05.9 Seropositive rheumatoid arthritis, unspecified
0.744 0.256 0.000
M05 Seropositive rheumatoid arthritis
0.743 0.257 0.000
M05-M14 Inflammatory polyarthropathies
0.743 0.257 0.000
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.262 0.738
D89 Other disorders involving the immune mechanism, not elsewhere classified
0.000 0.266 0.734
E10.8 With unspecified complications
0.000 0.274 0.726
D86.1 Sarcoidosis of lymph nodes
0.000 0.278 0.722
E10.6 With other specified complications
0.000 0.278 0.722
E05.5 Thyroid crisis or storm
0.000 0.283 0.717
E05.4 Thyrotoxicosis factitia
0.000 0.283 0.717
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.716
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.716
E15 Nondiabetic hypoglycaemic coma
0.000 0.284 0.716
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.284 0.716
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.284 0.716
E16.4 Abnormal secretion of gastrin
0.000 0.284 0.716
E16.3 Increased secretion of glucagon
0.000 0.284 0.716
M05.99 Seropositive rheumatoid arthritis, unspecified (Site unspecified)
0.713 0.287 0.000
E53 Deficiency of other B group vitamins
0.000 0.289 0.711
G36 Other acute disseminated demyelination
0.000 0.296 0.704
E51 Thiamine deficiency
0.000 0.299 0.701
E14.2 Withrenal complications
0.000 0.304 0.696
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.310 0.690
L40.1 Generalised pustular psoriasis
0.689 0.310 0.000
E61 Deficiency of other nutrient elements
0.000 0.313 0.687
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.314 0.686
D89.2 Hypergammaglobulinaemia, unspecified
0.000 0.314 0.686
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.684 0.316 0.000
L40.4 Guttate psoriasis
0.683 0.316 0.000
L40.3 Pustulosis palmaris et plantaris
0.682 0.317 0.000
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.321 0.679
E63 Other nutritional deficiencies
0.000 0.321 0.679
E50 Vitamin A deficiency
0.000 0.321 0.679
E60 Dietary zinc deficiency
0.000 0.321 0.679
E59 Dietary selenium deficiency
0.000 0.321 0.679
E54 Ascorbic acid deficiency
0.000 0.321 0.679
E52 Niacin deficiency [pellagra]
0.000 0.321 0.679
M06.98 Rheumatoid arthritis, unspecified (Other)
0.677 0.322 0.000
E13 Other specified diabetes mellitus
0.000 0.329 0.671
L40.2 Acrodermatitis continua
0.670 0.330 0.000
E56 Other vitamin deficiencies
0.000 0.331 0.669
K90 Intestinal malabsorption
0.000 0.334 0.666
M06.32 Rheumatoid nodule (Upper arm)
0.665 0.335 0.000
M06.34 Rheumatoid nodule (Hand)
0.663 0.337 0.000
G37.5 Concentric sclerosis [Balo]
0.000 0.342 0.658
G37.4 Subacute necrotising myelitis
0.000 0.342 0.658
G37.2 Central pontine myelinolysis
0.000 0.342 0.658
G37.1 Central demyelination of corpus callosum
0.000 0.342 0.658
G37.0 Diffuse sclerosis
0.000 0.342 0.658
D89.9 Disorder involving the immune mechanism, unspecified
0.000 0.347 0.653
E55.0 Rickets, active
0.000 0.350 0.650
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.649 0.351 0.000
M05.90 Seropositive rheumatoid arthritis, unspecified (Multiple sites)
0.648 0.352 0.000
E14.7 With multiple complications
0.000 0.354 0.645
E14.0 With coma
0.000 0.354 0.645
E20-E35 Disorders of other endocrine glands
0.000 0.364 0.636
E58 Dietary calcium deficiency
0.000 0.366 0.633
E27 Other disorders of adrenal gland
0.000 0.370 0.630
E27.1 Primary adrenocortical insufficiency
0.000 0.371 0.629
E46 Unspecified protein-energy malnutrition
0.000 0.372 0.628
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes
0.000 0.373 0.627
M06.33 Rheumatoid nodule (Forearm)
0.625 0.375 0.000
E14.5 With peripheral circulatory complications
0.000 0.378 0.622
L40-L45 Papulosquamous disorders
0.589 0.379 0.032
M06.07 Seronegative rheumatoid arthritis (Ankle and foot)
0.619 0.381 0.000
L40.8 Other psoriasis
0.602 0.398 0.000
K90.9 Intestinal malabsorption, unspecified
0.000 0.400 0.600
M06.36 Rheumatoid nodule (Lower leg)
0.600 0.400 0.000
M05.95 Seropositive rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.599 0.401 0.000
E04 Other non-toxic goitre
0.000 0.401 0.599
D82 Immunodeficiency associated with other major defects
0.000 0.404 0.596
E14.9 Without complications
0.000 0.406 0.594
M06.00 Seronegative rheumatoid arthritis (Multiple sites)
0.593 0.407 0.000
M06.1 Adult-onset Still's disease
0.590 0.410 0.000
M05.96 Seropositive rheumatoid arthritis, unspecified (Lower leg)
0.588 0.412 0.000
M06.2 Rheumatoid bursitis
0.587 0.413 0.000
M06.06 Seronegative rheumatoid arthritis (Lower leg)
0.586 0.414 0.000
M14 Arthropathies in other diseases classified elsewhere
0.586 0.414 0.000
M05.94 Seropositive rheumatoid arthritis, unspecified (Hand)
0.585 0.414 0.000
M05.1 Rheumatoid lung disease
0.583 0.417 0.000
M06.01 Seronegative rheumatoid arthritis (Shoulder region)
0.583 0.417 0.000
E61.2 Magnesium deficiency
0.000 0.418 0.582
M05.93 Seropositive rheumatoid arthritis, unspecified (Forearm)
0.581 0.419 0.000
M06.4 Inflammatory polyarthropathy
0.580 0.419 0.000
M05.91 Seropositive rheumatoid arthritis, unspecified (Shoulder region)
0.579 0.421 0.000
E14.1 With ketoacidosis
0.000 0.421 0.578
M05.8 Other seropositive rheumatoid arthritis
0.569 0.431 0.000
M05.97 Seropositive rheumatoid arthritis, unspecified (Ankle and foot)
0.569 0.431 0.000
D89.0 Polyclonal hypergammaglobulinaemia
0.000 0.435 0.565
M06.30 Rheumatoid nodule (Multiple sites)
0.565 0.435 0.000
M05.92 Seropositive rheumatoid arthritis, unspecified (Upper arm)
0.565 0.435 0.000
E53.9 Vitamin B deficiency, unspecified
0.000 0.437 0.563
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.438 0.561
E45 Retarded development following protein-energy malnutrition
0.000 0.438 0.561
E43 Unspecified severe protein-energy malnutrition
0.000 0.438 0.561
E42 Marasmic kwashiorkor
0.000 0.438 0.561
E41 Nutritional marasmus
0.000 0.438 0.561
E40 Kwashiorkor
0.000 0.438 0.561
E06 Thyroiditis
0.000 0.439 0.560
M08 Juvenile arthritis
0.559 0.441 0.000
M06.39 Rheumatoid nodule (Site unspecified)
0.556 0.444 0.000
M06.38 Rheumatoid nodule (Other)
0.556 0.444 0.000
M06.35 Rheumatoid nodule (Pelvic region and thigh)
0.556 0.444 0.000
M06.31 Rheumatoid nodule (Shoulder region)
0.556 0.444 0.000
M06.09 Seronegative rheumatoid arthritis (Site unspecified)
0.555 0.445 0.000
M06.37 Rheumatoid nodule (Ankle and foot)
0.553 0.447 0.000
D81 Combined immunodeficiencies
0.000 0.448 0.552
E07 Other disorders of thyroid
0.000 0.451 0.549
D86.3 Sarcoidosis of skin
0.000 0.451 0.548
M06.05 Seronegative rheumatoid arthritis (Pelvic region and thigh)
0.541 0.459 0.000
M06.08 Seronegative rheumatoid arthritis (Other)
0.537 0.463 0.000
M06.04 Seronegative rheumatoid arthritis (Hand)
0.537 0.463 0.000
M06.03 Seronegative rheumatoid arthritis (Forearm)
0.537 0.463 0.000
M06.02 Seronegative rheumatoid arthritis (Upper arm)
0.537 0.463 0.000
G36.0 Neuromyelitis optica [Devic]
0.000 0.464 0.536
M05.98 Seropositive rheumatoid arthritis, unspecified (Other)
0.533 0.467 0.000
M05.3 Rheumatoid arthritis with involvement of other organs and systems
0.533 0.467 0.000
M05.0 Felty's syndrome
0.533 0.467 0.000
M09 Juvenile arthritis in diseases classified elsewhere
0.533 0.467 0.000
M06.8 Other specified rheumatoid arthritis
0.533 0.467 0.000
E05.8 Other thyrotoxicosis
0.000 0.468 0.531
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.531 0.469 0.000
D80 Immunodeficiency with predominantly antibody defects
0.000 0.473 0.527
D89.3 Immune reconstitution syndrome
0.000 0.474 0.526
E51.2 Wernicke's encephalopathy
0.000 0.475 0.525
M11 Other crystal arthropathies
0.525 0.475 0.000
E27.2 Addisonian crisis
0.000 0.477 0.523
D83 Common variable immunodeficiency
0.000 0.483 0.517
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.486 0.514
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.486 0.514
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.486 0.514
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.486 0.514
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.486 0.514
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.486 0.514
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.486 0.514
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.486 0.514
L42 Pityriasis rosea
0.495 0.489 0.015
E04.2 Non-toxic multinodular goitre
0.000 0.490 0.510
E53.1 Pyridoxine deficiency
0.000 0.490 0.510
E53.0 Riboflavin deficiency
0.000 0.490 0.510
M05.2 Rheumatoid vasculitis
0.508 0.492 0.000
G36.9 Acute disseminated demyelination, unspecified
0.000 0.495 0.505
G36.8 Other specified acute disseminated demyelination
0.000 0.495 0.505
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.000 0.495 0.505
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.497 0.503
E51.9 Thiamine deficiency, unspecified
0.000 0.497 0.503
E51.8 Other manifestations of thiamine deficiency
0.000 0.497 0.503
E51.1 Beriberi
0.000 0.497 0.503
E20 Hypoparathyroidism
0.000 0.503 0.497
E27.8 Other specified disorders of adrenal gland
0.000 0.505 0.495
E61.9 Deficiency of nutrient element, unspecified
0.000 0.508 0.492
E61.8 Deficiency of other specified nutrient elements
0.000 0.508 0.492
E61.7 Deficiency of multiple nutrient elements
0.000 0.508 0.492
E61.6 Vanadium deficiency
0.000 0.508 0.492
E61.5 Molybdenum deficiency
0.000 0.508 0.492
E61.4 Chromium deficiency
0.000 0.508 0.492
E61.3 Manganese deficiency
0.000 0.508 0.492
E61.0 Copper deficiency
0.000 0.508 0.492
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.492 0.508 0.000
M14.6 Neuropathic arthropathy
0.489 0.511 0.000
E50.9 Vitamin A deficiency, unspecified
0.000 0.513 0.487
E50.8 Other manifestations of vitamin A deficiency
0.000 0.513 0.487
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.513 0.487
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.513 0.487
E50.5 Vitamin A deficiency with night blindness
0.000 0.513 0.487
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.513 0.487
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.513 0.487
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.513 0.487
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.513 0.487
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.513 0.487
E63.9 Nutritional deficiency, unspecified
0.000 0.513 0.487
E63.8 Other specified nutritional deficiencies
0.000 0.513 0.487
E63.1 Imbalance of constituents of food intake
0.000 0.513 0.487
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.513 0.487
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.513 0.487
E64.8 Sequelae of other nutritional deficiencies
0.000 0.513 0.487
E64.3 Sequelae of rickets
0.000 0.513 0.487
E64.2 Sequelae of vitamin C deficiency
0.000 0.513 0.487
E64.1 Sequelae of vitamin A deficiency
0.000 0.513 0.487
E64.0 Sequelae of protein-energy malnutrition
0.000 0.513 0.487
D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified
0.000 0.516 0.484
E53.8 Deficiency of other specified B group vitamins
0.000 0.518 0.482
E13.8 With unspecified complications
0.000 0.519 0.481
E13.7 With multiple complications
0.000 0.519 0.481
E13.6 With other specified complications
0.000 0.519 0.481
E13.5 With peripheral circulatory complications
0.000 0.519 0.481
E13.4 With neurological complications
0.000 0.519 0.481
E13.2 With renal complications
0.000 0.519 0.481
E13.1 With ketoacidosis
0.000 0.519 0.481
E13.0 With coma
0.000 0.519 0.481
E13.9 Without complications
0.000 0.519 0.481
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.480 0.520 0.000
E56.9 Vitamin deficiency, unspecified
0.000 0.520 0.480
E56.8 Deficiency of other vitamins
0.000 0.520 0.480
E56.0 Deficiency of vitamin E
0.000 0.520 0.480
K90.3 Pancreatic steatorrhoea
0.000 0.522 0.478
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.522 0.478
K90.1 Tropical sprue
0.000 0.522 0.478
E14.4 With neurological complications
0.000 0.523 0.477
E34 Other endocrine disorders
0.000 0.527 0.473
L44 Other papulosquamous disorders
0.451 0.528 0.021
D82.1 Di George's syndrome
0.000 0.529 0.471
E56.1 Deficiency of vitamin K
0.000 0.530 0.470
M05.19 Rheumatoid lung disease (Site unspecified)
0.469 0.531 0.000
E31 Polyglandular dysfunction
0.000 0.534 0.466
H36.0 Diabetic retinopathy
0.000 0.540 0.460
E04.0 Non-toxic diffuse goitre
0.000 0.543 0.457
E16.1 Other hypoglycaemia
0.001 0.543 0.456
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.544 0.456
E32 Diseases of thymus
0.000 0.544 0.456
E30 Disorders of puberty, not elsewhere classified
0.000 0.544 0.456
M07 Psoriatic and enteropathic arthropathies
0.455 0.545 0.000
E27.5 Adrenomedullary hyperfunction
0.000 0.548 0.452
E27.0 Other adrenocortical overactivity
0.000 0.548 0.452
D84 Other immunodeficiencies
0.000 0.550 0.450
M12 Other specific arthropathies
0.448 0.551 0.000
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.554 0.446
L41 Parapsoriasis
0.422 0.555 0.023
L45 Papulosquamous disorders in diseases classified elsewhere
0.422 0.555 0.023
M05.80 Other seropositive rheumatoid arthritis (Multiple sites)
0.443 0.556 0.000
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.439 0.561 0.000
D89.1 Cryoglobulinaemia
0.000 0.562 0.438
M06.46 Inflammatory polyarthropathy (Lower leg)
0.438 0.562 0.000
E28 Ovarian dysfunction
0.000 0.563 0.437
E13.3 With ophthalmic complications
0.000 0.565 0.435
M06.49 Inflammatory polyarthropathy (Site unspecified)
0.435 0.565 0.000
E04.8 Other specified non-toxic goitre
0.000 0.571 0.429
D82.9 Immunodeficiency associated with major defect, unspecified
0.000 0.573 0.427
D82.8 Immunodeficiency associated with other specified major defects
0.000 0.573 0.427
D82.4 Hyperimmunoglobulin E [IgE] syndrome
0.000 0.573 0.427
D82.3 Immunodeficiency following hereditary defective response to Epstein-Barr virus
0.000 0.573 0.427
D82.2 Immunodeficiency with short-limbed stature
0.000 0.573 0.427
D82.0 Wiskott-Aldrich syndrome
0.000 0.573 0.427
M08.0 Juvenile rheumatoid arthritis
0.427 0.573 0.000
M06.10 Adult-onset Still's disease (Multiple sites)
0.427 0.573 0.000
D80.1 Nonfamilial hypogammaglobulinaemia
0.000 0.573 0.427
E06.5 Other chronic thyroiditis
0.000 0.575 0.425
M06.19 Adult-onset Still's disease (Site unspecified)
0.423 0.577 0.000
M06.18 Adult-onset Still's disease (Other)
0.423 0.577 0.000
M06.17 Adult-onset Still's disease (Ankle and foot)
0.423 0.577 0.000
M06.16 Adult-onset Still's disease (Lower leg)
0.423 0.577 0.000
M06.15 Adult-onset Still's disease (Pelvic region and thigh)
0.423 0.577 0.000
M06.14 Adult-onset Still's disease (Hand)
0.423 0.577 0.000
M06.13 Adult-onset Still's disease (Forearm)
0.423 0.577 0.000
M06.12 Adult-onset Still's disease (Upper arm)
0.423 0.577 0.000
M06.11 Adult-onset Still's disease (Shoulder region)
0.423 0.577 0.000
M06.29 Rheumatoid bursitis (Site unspecified)
0.421 0.579 0.000
M06.28 Rheumatoid bursitis (Other)
0.421 0.579 0.000
M06.27 Rheumatoid bursitis (Ankle and foot)
0.421 0.579 0.000
M06.26 Rheumatoid bursitis (Lower leg)
0.421 0.579 0.000
M06.25 Rheumatoid bursitis (Pelvic region and thigh)
0.421 0.579 0.000
M06.24 Rheumatoid bursitis (Hand)
0.421 0.579 0.000
M06.23 Rheumatoid bursitis (Forearm)
0.421 0.579 0.000
M06.22 Rheumatoid bursitis (Upper arm)
0.421 0.579 0.000
M06.21 Rheumatoid bursitis (Shoulder region)
0.421 0.579 0.000
M06.20 Rheumatoid bursitis (Multiple sites)
0.421 0.579 0.000
M14.8 Arthropathies in other specified diseases classified elsewhere
0.420 0.580 0.000
M14.5 Arthropathies in other endocrine, nutritional and metabolic disorders
0.420 0.580 0.000
M14.4 Arthropathy in amyloidosis
0.420 0.580 0.000
M14.3 Lipoid dermatoarthritis
0.420 0.580 0.000
M14.1 Crystal arthropathy in other metabolic disorders
0.420 0.580 0.000
M14.0 Gouty arthropathy due to enzyme defects and other inherited disorders
0.420 0.580 0.000
H36 Retinal disorders in diseases classified elsewhere
0.000 0.581 0.419
K90.8 Other intestinal malabsorption
0.000 0.581 0.418
M05.18 Rheumatoid lung disease (Other)
0.418 0.581 0.000
M05.17 Rheumatoid lung disease (Ankle and foot)
0.418 0.581 0.000
M05.16 Rheumatoid lung disease (Lower leg)
0.418 0.581 0.000
M05.15 Rheumatoid lung disease (Pelvic region and thigh)
0.418 0.581 0.000
M05.14 Rheumatoid lung disease (Hand)
0.418 0.581 0.000
M05.13 Rheumatoid lung disease (Forearm)
0.418 0.581 0.000
M05.12 Rheumatoid lung disease (Upper arm)
0.418 0.581 0.000
M05.11 Rheumatoid lung disease (Shoulder region)
0.418 0.581 0.000
M05.10 Rheumatoid lung disease (Multiple sites)
0.418 0.581 0.000
M06.48 Inflammatory polyarthropathy (Other)
0.416 0.584 0.000
M06.47 Inflammatory polyarthropathy (Ankle and foot)
0.416 0.584 0.000
M06.45 Inflammatory polyarthropathy (Pelvic region and thigh)
0.416 0.584 0.000
M06.44 Inflammatory polyarthropathy (Hand)
0.416 0.584 0.000
M06.43 Inflammatory polyarthropathy (Forearm)
0.416 0.584 0.000
M06.42 Inflammatory polyarthropathy (Upper arm)
0.416 0.584 0.000
M06.41 Inflammatory polyarthropathy (Shoulder region)
0.416 0.584 0.000
M11.9 Crystal arthropathy, unspecified
0.412 0.588 0.000
E34.8 Other specified endocrine disorders
0.000 0.590 0.410
M05.89 Other seropositive rheumatoid arthritis (Site unspecified)
0.410 0.590 0.000
M05.88 Other seropositive rheumatoid arthritis (Other)
0.408 0.592 0.000
M05.87 Other seropositive rheumatoid arthritis (Ankle and foot)
0.408 0.592 0.000
M05.86 Other seropositive rheumatoid arthritis (Lower leg)
0.408 0.592 0.000
M05.85 Other seropositive rheumatoid arthritis (Pelvic region and thigh)
0.408 0.592 0.000
M05.84 Other seropositive rheumatoid arthritis (Hand)
0.408 0.592 0.000
M05.83 Other seropositive rheumatoid arthritis (Forearm)
0.408 0.592 0.000
M05.82 Other seropositive rheumatoid arthritis (Upper arm)
0.408 0.592 0.000
M05.81 Other seropositive rheumatoid arthritis (Shoulder region)
0.408 0.592 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.000 0.595 0.405
C21.0 Anus, unspecified
0.404 0.596 0.000
E44.1 Mild protein-energy malnutrition
0.000 0.597 0.403
E44.0 Moderate protein-energy malnutrition
0.000 0.597 0.403
E06.4 Drug-induced thyroiditis
0.000 0.598 0.402
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.598 0.402
E06.0 Acute thyroiditis
0.000 0.598 0.402
M08.9 Juvenile arthritis, unspecified
0.401 0.599 0.000
M08.8 Other juvenile arthritis
0.401 0.599 0.000
M08.4 Pauciarticular juvenile arthritis
0.401 0.599 0.000
M08.3 Juvenile polyarthritis (seronegative)
0.401 0.599 0.000
M08.2 Juvenile arthritis with systemic onset
0.401 0.599 0.000
M08.1 Juvenile ankylosing spondylitis
0.401 0.599 0.000
L43 Lichen planus
0.388 0.599 0.012
E06.1 Subacute thyroiditis
0.000 0.600 0.399
E20.9 Hypoparathyroidism, unspecified
0.000 0.603 0.397
D81.9 Combined immunodeficiency, unspecified
0.000 0.604 0.396
D81.8 Other combined immunodeficiencies
0.000 0.604 0.396
D81.7 Major histocompatibility complex class II deficiency
0.000 0.604 0.396
D81.6 Major histocompatibility complex class I deficiency
0.000 0.604 0.396
D81.5 Purine nucleoside phosphorylase [PNP] deficiency
0.000 0.604 0.396
D81.4 Nezelof's syndrome
0.000 0.604 0.396
D81.3 Adenosine deaminase [ADA] deficiency
0.000 0.604 0.396
D81.2 Severe combined immunodeficiency [SCID] with low or normal B-cell numbers
0.000 0.604 0.396
D81.1 Severe combined immunodeficiency [SCID] with low T- and B-cell numbers
0.000 0.604 0.396
D81.0 Severe combined immunodeficiency [SCID] with reticular dysgenesis
0.000 0.604 0.396
C21.1 Anal canal
0.396 0.604 0.000
M14.2 Diabetic arthropathy
0.394 0.606 0.000
C21 Malignant neoplasm of anus and anal canal
0.394 0.606 0.000
E07.1 Dyshormogenetic goitre
0.000 0.606 0.394
E07.0 Hypersecretion of calcitonin
0.000 0.606 0.394
H04 Disorders of lachrymal system
0.000 0.608 0.392
H00-H06 Disorders of eyelid, lacrimal system and orbit
0.000 0.610 0.390
H30-H36 Disorders of choroid and retina
0.000 0.610 0.390
E06.9 Thyroiditis, unspecified
0.000 0.611 0.389
M06.89 Other specified rheumatoid arthritis (Site unspecified)
0.386 0.613 0.000
D80.2 Selective deficiency of immunoglobulin A [IgA]
0.000 0.613 0.386
M13 Other arthritis
0.384 0.616 0.000
M05.09 Felty's syndrome (Site unspecified)
0.382 0.618 0.000
M05.08 Felty's syndrome (Other)
0.382 0.618 0.000
M05.07 Felty's syndrome (Ankle and foot)
0.382 0.618 0.000
M05.06 Felty's syndrome (Lower leg)
0.382 0.618 0.000
M05.05 Felty's syndrome (Pelvic region and thigh)
0.382 0.618 0.000
M05.04 Felty's syndrome (Hand)
0.382 0.618 0.000
M05.03 Felty's syndrome (Forearm)
0.382 0.618 0.000
M05.02 Felty's syndrome (Upper arm)
0.382 0.618 0.000
M05.01 Felty's syndrome (Shoulder region)
0.382 0.618 0.000
M05.00 Felty's syndrome (Multiple sites)
0.382 0.618 0.000
M05.39 Rheumatoid arthritis with involvement of other organs and systems (Site unspecified)
0.382 0.618 0.000
M05.38 Rheumatoid arthritis with involvement of other organs and systems (Other)
0.382 0.618 0.000
M05.37 Rheumatoid arthritis with involvement of other organs and systems (Ankle and foot)
0.382 0.618 0.000
M05.36 Rheumatoid arthritis with involvement of other organs and systems (Lower leg)
0.382 0.618 0.000
M05.35 Rheumatoid arthritis with involvement of other organs and systems (Pelvic region and thigh)
0.382 0.618 0.000
M05.34 Rheumatoid arthritis with involvement of other organs and systems (Hand)
0.382 0.618 0.000
M05.33 Rheumatoid arthritis with involvement of other organs and systems (Forearm)
0.382 0.618 0.000
M05.32 Rheumatoid arthritis with involvement of other organs and systems (Upper arm)
0.382 0.618 0.000
M05.31 Rheumatoid arthritis with involvement of other organs and systems (Shoulder region)
0.382 0.618 0.000
M05.30 Rheumatoid arthritis with involvement of other organs and systems (Multiple sites)
0.382 0.618 0.000
M09.8 Juvenile arthritis in other diseases classified elsewhere
0.382 0.618 0.000
M09.2 Juvenile arthritis in ulcerative colitis
0.382 0.618 0.000
M09.1 Juvenile arthritis in Crohn's disease [regional enteritis]
0.382 0.618 0.000
M09.0 Juvenile arthritis in psoriasis
0.382 0.618 0.000
M06.88 Other specified rheumatoid arthritis (Other)
0.382 0.618 0.000
M06.87 Other specified rheumatoid arthritis (Ankle and foot)
0.382 0.618 0.000
M06.86 Other specified rheumatoid arthritis (Lower leg)
0.382 0.618 0.000
M06.85 Other specified rheumatoid arthritis (Pelvic region and thigh)
0.382 0.618 0.000
M06.84 Other specified rheumatoid arthritis (Hand)
0.382 0.618 0.000
M06.83 Other specified rheumatoid arthritis (Forearm)
0.382 0.618 0.000
M06.82 Other specified rheumatoid arthritis (Upper arm)
0.382 0.618 0.000
M06.81 Other specified rheumatoid arthritis (Shoulder region)
0.382 0.618 0.000
E25 Adrenogenital disorders
0.000 0.618 0.381
E26 Hyperaldosteronism
0.000 0.621 0.379
D80.8 Other immunodeficiencies with predominantly antibody defects
0.000 0.622 0.378
D80.7 Transient hypogammaglobulinaemia of infancy
0.000 0.622 0.378
D80.6 Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinaemia
0.000 0.622 0.378
D80.5 Immunodeficiency with increased immunoglobulin M [IgM]
0.000 0.622 0.378
D80.0 Hereditary hypogammaglobulinaemia
0.000 0.622 0.378
D80.3 Selective deficiency of immunoglobulin G [IgG] subclasses
0.000 0.622 0.378
H04.8 Other disorders of lachrymal system
0.000 0.623 0.377
M11.1 Familial chondrocalcinosis
0.376 0.624 0.000
M11.0 Hydroxyapatite deposition disease
0.376 0.624 0.000
Chapter VII Diseases of the eye and adnexa
0.000 0.626 0.374
D83.8 Other common variable immunodeficiencies
0.000 0.629 0.371
D83.2 Common variable immunodeficiency with autoantibodies to B- or T-cells
0.000 0.629 0.371
D83.1 Common variable immunodeficiency with predominant immunoregulatory T-cell disorders
0.000 0.629 0.371
D83.0 Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
0.000 0.629 0.371
E27.9 Disorder of adrenal gland, unspecified
0.000 0.634 0.366
E07.8 Other specified disorders of thyroid
0.000 0.634 0.366
H33 Retinal detachments and breaks
0.000 0.634 0.366
E24 Cushing's syndrome
0.000 0.634 0.366
L44.0 Pityriasis rubra pilaris
0.352 0.635 0.013
M05.28 Rheumatoid vasculitis (Other)
0.364 0.636 0.000
M05.27 Rheumatoid vasculitis (Ankle and foot)
0.364 0.636 0.000
M05.26 Rheumatoid vasculitis (Lower leg)
0.364 0.636 0.000
M05.25 Rheumatoid vasculitis (Pelvic region and thigh)
0.364 0.636 0.000
M05.24 Rheumatoid vasculitis (Hand)
0.364 0.636 0.000
M05.23 Rheumatoid vasculitis (Forearm)
0.364 0.636 0.000
M05.22 Rheumatoid vasculitis (Upper arm)
0.364 0.636 0.000
M05.21 Rheumatoid vasculitis (Shoulder region)
0.364 0.636 0.000
H06 Disorders of lachrymal system and orbit in diseases classified elsewhere
0.000 0.637 0.363
H04.1 Other disorders of lachrymal gland
0.000 0.640 0.360
M06.40 Inflammatory polyarthropathy (Multiple sites)
0.359 0.641 0.000
M11.8 Other specified crystal arthropathies
0.359 0.641 0.000
# Top node
0.000 0.641 0.359
Chapter XII Diseases of the skin and subcutaneous tissue
0.000 0.642 0.358
H04.3 Acute and unspecified inflammation of lachrymal passages
0.000 0.643 0.357
E20.8 Other hypoparathyroidism
0.000 0.644 0.356
E20.1 Pseudohypoparathyroidism
0.000 0.644 0.356
E20.0 Idiopathic hypoparathyroidism
0.000 0.644 0.356
E04.9 Non-toxic goitre, unspecified
0.000 0.644 0.356
H33.3 Retinal breaks without detachment
0.000 0.646 0.354
E23 Hypofunction and other disorders of pituitary gland
0.000 0.648 0.352
M05.29 Rheumatoid vasculitis (Site unspecified)
0.352 0.648 0.000
M05.20 Rheumatoid vasculitis (Multiple sites)
0.351 0.648 0.000
Chapter VI Diseases of the nervous system
0.000 0.651 0.349
E28.3 Primary ovarian failure
0.000 0.653 0.347
E31.0 Autoimmune polyglandular failure
0.000 0.656 0.344
H06.2 Dysthyroid exophthalmos
0.000 0.656 0.344
D80.4 Selective deficiency of immunoglobulin M [IgM]
0.000 0.657 0.343
L20-L30 Dermatitis and eczema
0.000 0.657 0.343
H02 Other disorders of eyelid
0.000 0.658 0.342
E61.1 Iron deficiency
0.000 0.658 0.341
M11.2 Other chondrocalcinosis
0.340 0.660 0.000
E34.5 Androgen resistance syndrome
0.000 0.661 0.339
E34.4 Constitutional tall stature
0.000 0.661 0.339
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.661 0.339
E34.1 Other hypersecretion of intestinal hormones
0.000 0.661 0.339
L60-L75 Disorders of skin appendages
0.000 0.661 0.339
L44.9 Papulosquamous disorder, unspecified
0.323 0.661 0.015
L44.8 Other specified papulosquamous disorders
0.323 0.661 0.015
L44.4 Infantile papular acrodermatitis [Giannotti-Crosti]
0.323 0.661 0.015
L44.3 Lichen ruber moniliformis
0.323 0.661 0.015
L44.2 Lichen striatus
0.323 0.661 0.015
L44.1 Lichen nitidus
0.323 0.661 0.015
D83.9 Common variable immunodeficiency, unspecified
0.000 0.665 0.335
E31.9 Polyglandular dysfunction, unspecified
0.000 0.666 0.334
E31.8 Other polyglandular dysfunction
0.000 0.666 0.334
E31.1 Polyglandular hyperfunction
0.000 0.666 0.334
M08.00 Juvenile rheumatoid arthritis (Multiple sites)
0.332 0.668 0.000
H46-H48 Disorders of optic nerve and visual pathways
0.000 0.669 0.331
M11.96 Crystal arthropathy, unspecified (Lower leg)
0.331 0.669 0.000
H05 Disorders of orbit
0.000 0.669 0.331
L50-L54 Urticaria and erythema
0.000 0.671 0.329
E34.0 Carcinoid syndrome
0.000 0.671 0.328
E30.9 Disorder of puberty, unspecified
0.000 0.673 0.327
E30.8 Other disorders of puberty
0.000 0.673 0.327
E30.1 Precocious puberty
0.000 0.673 0.327

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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