TreeWAS – Variant ID: rs1632879

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
E83.1 Disorders of iron metabolism	1.000	0.000	0.000
G35 Multiple sclerosis	0.821	0.179	0.000
E83 Disorders of mineral metabolism	0.477	0.523	0.000
E89.0 Postprocedural hypothyroidism	0.456	0.544	0.000
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified	0.441	0.559	0.000
E70-E90 Metabolic disorders	0.410	0.590	0.000
E89.2 Postprocedural hypoparathyroidism	0.402	0.598	0.000
E89.6 Postprocedural adrenocortical(-medullary) hypofunction	0.354	0.646	0.000
E89.4 Postprocedural ovarian failure	0.351	0.649	0.000
E80 Disorders of porphyrin and bilirubin metabolism	0.347	0.653	0.000
E83.9 Disorder of mineral metabolism, unspecified	0.342	0.658	0.000
E83.8 Other disorders of mineral metabolism	0.342	0.658	0.000
E83.2 Disorders of zinc metabolism	0.342	0.658	0.000
E83.0 Disorders of copper metabolism	0.342	0.658	0.000
E84 Cystic fibrosis	0.333	0.667	0.000
E89.9 Postprocedural endocrine and metabolic disorder, unspecified	0.317	0.683	0.000
E89.8 Other postprocedural endocrine and metabolic disorders	0.317	0.683	0.000
E89.5 Postprocedural testicular hypofunction	0.317	0.683	0.000
E89.1 Postprocedural hypoinsulinaemia	0.317	0.683	0.000
E73 Lactose intolerance	0.298	0.701	0.000
E77 Disorders of glycoprotein metabolism	0.294	0.706	0.000
E76 Disorders of glycosaminoglycan metabolism	0.294	0.706	0.000
E75 Disorders of sphingolipid metabolism and other lipid storage disorders	0.294	0.706	0.000
E72 Other disorders of amino-acid metabolism	0.294	0.706	0.000
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism	0.294	0.706	0.000
E70 Disorders of aromatic amino-acid metabolism	0.294	0.706	0.000
E90 Nutritional and metabolic disorders in diseases classified elsewhere	0.294	0.706	0.000
E80.1 Porphyria cutanea tarda	0.293	0.707	0.000
E74 Other disorders of carbohydrate metabolism	0.290	0.710	0.000
E79 Disorders of purine and pyrimidine metabolism	0.287	0.713	0.000
E84.9 Cystic fibrosis, unspecified	0.278	0.722	0.000
E83.3 Disorders of phosphorus metabolism	0.278	0.722	0.000
E80.6 Other disorders of bilirubin metabolism	0.259	0.741	0.000
E83.5 Disorders of calcium metabolism	0.256	0.744	0.000
E80.4 Gilbert's syndrome	0.256	0.744	0.000
G35-G37 Demyelinating diseases of the central nervous system	0.250	0.750	0.000
E80.7 Disorder of bilirubin metabolism, unspecified	0.249	0.751	0.000
E80.5 Crigler-Najjar syndrome	0.249	0.751	0.000
E80.3 Defects of catalase and peroxydase	0.249	0.751	0.000
E80.2 Other porphyria	0.249	0.751	0.000
E80.0 Hereditary erythropoietic porphyria	0.249	0.751	0.000
E84.8 Cystic fibrosis with other manifestations	0.239	0.761	0.000
E84.1 Cystic fibrosis with intestinal manifestations	0.239	0.761	0.000
E84.0 Cystic fibrosis with pulmonary manifestations	0.239	0.761	0.000
E73.9 Lactose intolerance, unspecified	0.219	0.781	0.000
E88 Other metabolic disorders	0.218	0.782	0.000
E73.8 Other lactose intolerance	0.214	0.786	0.000
E73.1 Secondary lactase deficiency	0.214	0.786	0.000
E73.0 Congenital lactase deficiency	0.214	0.786	0.000
E70.9 Disorder of aromatic amino-acid metabolism, unspecified	0.211	0.789	0.000
E70.8 Other disorders of aromatic amino-acid metabolism	0.211	0.789	0.000
E70.3 Albinism	0.211	0.789	0.000
E70.2 Disorders of tyrosine metabolism	0.211	0.789	0.000
E70.1 Other hyperphenylalaninaemias	0.211	0.789	0.000
E70.0 Classical phenylketonuria	0.211	0.789	0.000
E71.3 Disorders of fatty-acid metabolism	0.211	0.789	0.000
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified	0.211	0.789	0.000
E71.1 Other disorders of branched-chain amino-acid metabolism	0.211	0.789	0.000
E71.0 Maple-syrup-urine disease	0.211	0.789	0.000
E72.9 Disorder of amino-acid metabolism, unspecified	0.211	0.789	0.000
E72.8 Other specified disorders of amino-acid metabolism	0.211	0.789	0.000
E72.5 Disorders of glycine metabolism	0.211	0.789	0.000
E72.4 Disorders of ornithine metabolism	0.211	0.789	0.000
E72.3 Disorders of lysine and hydroxylysine metabolism	0.211	0.789	0.000
E72.2 Disorders of urea cycle metabolism	0.211	0.789	0.000
E72.1 Disorders of sulphur-bearing amino-acid metabolism	0.211	0.789	0.000
E72.0 Disorders of amino-acid transport	0.211	0.789	0.000
E75.6 Lipid storage disorder, unspecified	0.211	0.789	0.000
E75.5 Other lipid storage disorders	0.211	0.789	0.000
E75.4 Neuronal ceroid lipofuscinosis	0.211	0.789	0.000
E75.3 Sphingolipidosis, unspecified	0.211	0.789	0.000
E75.2 Other sphingolipidosis	0.211	0.789	0.000
E75.1 Other gangliosidosis	0.211	0.789	0.000
E75.0 GM2 gangliosidosis	0.211	0.789	0.000
E76.9 Disorder of glucosaminoglycan metabolism, unspecified	0.211	0.789	0.000
E76.8 Other disorders of glucosaminoglycan metabolism	0.211	0.789	0.000
E76.3 Mucopolysaccharidosis, unspecified	0.211	0.789	0.000
E76.2 Other mucopolysaccharidoses	0.211	0.789	0.000
E76.1 Mucopolysaccharidosis, type II	0.211	0.789	0.000
E76.0 Mucopolysaccharidosis, type I	0.211	0.789	0.000
E77.9 Disorder of glycoprotein metabolism, unspecified	0.211	0.789	0.000
E77.8 Other disorders of glycoprotein metabolism	0.211	0.789	0.000
E77.1 Defects in glycoprotein degradation	0.211	0.789	0.000
E77.0 Defects in posttranslational modification of lysosomal enzymes	0.211	0.789	0.000
E74.9 Disorder of carbohydrate metabolism, unspecified	0.208	0.792	0.000
E74.8 Other specified disorders of carbohydrate metabolism	0.208	0.792	0.000
E74.4 Disorders of pyruvate metabolism and gluconeogenesis	0.208	0.792	0.000
E74.2 Disorders of galactose metabolism	0.208	0.792	0.000
E74.1 Disorders of fructose metabolism	0.208	0.792	0.000
E74.0 Glycogen storage disease	0.208	0.792	0.000
E79.9 Disorder of purine and pyrimidine metabolism, unspecified	0.206	0.794	0.000
E79.8 Other disorders of purine and pyrimidine metabolism	0.206	0.794	0.000
E79.1 Lesch-Nyhan syndrome	0.206	0.794	0.000
E74.3 Other disorders of intestinal carbohydrate absorption	0.204	0.796	0.000
E85 Amyloidosis	0.202	0.798	0.000
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease	0.199	0.801	0.000
G36 Other acute disseminated demyelination	0.179	0.820	0.000
E89.3 Postprocedural hypopituitarism	0.178	0.822	0.001
E83.4 Disorders of magnesium metabolism	0.169	0.831	0.000
E88.1 Lipodystrophy, not elsewhere classified	0.162	0.838	0.000
E88.8 Other specified metabolic disorders	0.157	0.842	0.000
E88.9 Metabolic disorder, unspecified	0.156	0.844	0.000
E88.3 Tumour lysis syndrome	0.156	0.844	0.000
E85.8 Other amyloidosis	0.145	0.855	0.000
E85.2 Heredofamilial amyloidosis, unspecified	0.145	0.855	0.000
E85.1 Neuropathic heredofamilial amyloidosis	0.145	0.855	0.000
E85.0 Nonneuropathic heredofamilial amyloidosis	0.145	0.855	0.000
E85.3 Secondary systemic amyloidosis	0.139	0.860	0.000
G37 Other demyelinating diseases of central nervous system	0.133	0.866	0.000
E88.2 Lipomatosis, not elsewhere classified	0.133	0.867	0.000
G36.9 Acute disseminated demyelination, unspecified	0.129	0.871	0.000
G36.8 Other specified acute disseminated demyelination	0.129	0.871	0.000
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]	0.129	0.871	0.000
G36.0 Neuromyelitis optica [Devic]	0.129	0.871	0.000
E85.9 Amyloidosis, unspecified	0.118	0.881	0.000
E85.4 Organ-limited amyloidosis	0.109	0.890	0.000
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified	0.105	0.895	0.000
G37.8 Other specified demyelinating diseases of central nervous system	0.096	0.903	0.000
G37.5 Concentric sclerosis [Balo]	0.096	0.904	0.000
G37.4 Subacute necrotising myelitis	0.096	0.904	0.000
G37.2 Central pontine myelinolysis	0.096	0.904	0.000
G37.1 Central demyelination of corpus callosum	0.096	0.904	0.000
G37.0 Diffuse sclerosis	0.096	0.904	0.000
Chapter IV Endocrine, nutritional and metabolic diseases	0.093	0.907	0.000
E00-E07 Disorders of thyroid gland	0.085	0.915	0.000
K70 Alcoholic liver disease	0.083	0.917	0.000
E03.9 Hypothyroidism, unspecified	0.083	0.917	0.000
E03 Other hypothyroidism	0.082	0.918	0.000
K70.3 Alcoholic cirrhosis of liver	0.082	0.918	0.000
G37.9 Demyelinating disease of central nervous system, unspecified	0.081	0.918	0.000
K70.2 Alcoholic fibrosis and sclerosis of liver	0.076	0.924	0.000
K70.9 Alcoholic liver disease, unspecified	0.076	0.924	0.000
E06 Thyroiditis	0.075	0.925	0.000
E65-E68 Obesity and other hyperalimentation	0.073	0.927	0.000
K70.4 Alcoholic hepatic failure	0.073	0.927	0.000
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system	0.072	0.928	0.000
E40-E46 Malnutrition	0.071	0.929	0.000
E50-E64 Other nutritional deficiencies	0.069	0.931	0.000
E06.3 Autoimmune thyroiditis	0.069	0.931	0.000
E65 Localised adiposity	0.067	0.933	0.000
K76 Other diseases of liver	0.066	0.934	0.000
K70-K77 Diseases of liver	0.066	0.934	0.000
K76.6 Portal hypertension	0.065	0.935	0.000
K70.0 Alcoholic fatty liver	0.063	0.937	0.000
E01 Iodine-deficiency-related thyroid disorders and allied conditions	0.061	0.939	0.000
E00 Congenital iodine-deficiency syndrome	0.061	0.939	0.000
E02 Subclinical iodine-deficiency hypothyroidism	0.061	0.939	0.000
E53 Deficiency of other B group vitamins	0.061	0.939	0.000
K75 Other inflammatory liver diseases	0.060	0.940	0.000
K76.0 Fatty (change of) liver, not elsewhere classified	0.059	0.941	0.000
E03.5 Myxoedema coma	0.059	0.941	0.000
E03.4 Atrophy of thyroid (acquired)	0.059	0.941	0.000
E03.3 Postinfectious hypothyroidism	0.059	0.941	0.000
E03.1 Congenital hypothyroidism without goitre	0.059	0.941	0.000
E03.0 Congenital hypothyroidism with diffuse goitre	0.059	0.941	0.000
E05 Thyrotoxicosis [hyperthyroidism]	0.056	0.944	0.000
E46 Unspecified protein-energy malnutrition	0.056	0.944	0.000
E53.8 Deficiency of other specified B group vitamins	0.056	0.944	0.000
I83.9 Varicose veins of lower extremities without ulcer or inflammation	0.055	0.945	0.000
K75.0 Abscess of liver	0.055	0.945	0.000
E04 Other non-toxic goitre	0.054	0.946	0.000
E06.5 Other chronic thyroiditis	0.054	0.946	0.000
E06.4 Drug-induced thyroiditis	0.054	0.946	0.000
E06.2 Chronic thyroiditis with transient thyrotoxicosis	0.054	0.946	0.000
E06.1 Subacute thyroiditis	0.054	0.946	0.000
E06.0 Acute thyroiditis	0.054	0.946	0.000
E58 Dietary calcium deficiency	0.053	0.946	0.000
E67 Other hyperalimentation	0.053	0.947	0.000
E68 Sequelae of hyperalimentation	0.053	0.947	0.000
E03.2 Hypothyroidism due to medicaments and other exogenous substances	0.052	0.948	0.000
K71 Toxic liver disease	0.052	0.948	0.000
E44 Protein-energy malnutrition of moderate and mild degree	0.051	0.949	0.000
E45 Retarded development following protein-energy malnutrition	0.051	0.949	0.000
E43 Unspecified severe protein-energy malnutrition	0.051	0.949	0.000
E42 Marasmic kwashiorkor	0.051	0.949	0.000
E41 Nutritional marasmus	0.051	0.949	0.000
E40 Kwashiorkor	0.051	0.949	0.000
K75.8 Other specified inflammatory liver diseases	0.051	0.949	0.000
L03.1 Cellulitis of other parts of limb	0.051	0.949	0.000
K76.7 Hepatorenal syndrome	0.051	0.949	0.000
E05.9 Thyrotoxicosis, unspecified	0.050	0.950	0.000
E06.9 Thyroiditis, unspecified	0.050	0.950	0.000
E64 Sequelae of malnutrition and other nutritional deficiencies	0.050	0.950	0.000
E63 Other nutritional deficiencies	0.050	0.950	0.000
E56 Other vitamin deficiencies	0.050	0.950	0.000
E51 Thiamine deficiency	0.050	0.950	0.000
E50 Vitamin A deficiency	0.050	0.950	0.000
E60 Dietary zinc deficiency	0.050	0.950	0.000
E59 Dietary selenium deficiency	0.050	0.950	0.000
E54 Ascorbic acid deficiency	0.050	0.950	0.000
E52 Niacin deficiency [pellagra]	0.050	0.950	0.000
E04.2 Non-toxic multinodular goitre	0.049	0.951	0.000
K76.8 Other specified diseases of liver	0.048	0.952	0.000
K76.5 Hepatic veno-occlusive disease	0.048	0.952	0.000
K76.4 Peliosis hepatis	0.048	0.952	0.000
K76.3 Infarction of liver	0.048	0.952	0.000
K76.2 Central haemorrhagic necrosis of liver	0.048	0.952	0.000
K76.1 Chronic passive congestion of liver	0.048	0.952	0.000
K77 Liver disorders in diseases classified elsewhere	0.047	0.952	0.000
E03.8 Other specified hypothyroidism	0.047	0.953	0.000
K75.3 Granulomatous hepatitis, not elsewhere classified	0.046	0.954	0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion	0.046	0.954	0.000
E00.9 Congenital iodine-deficiency syndrome, unspecified	0.044	0.956	0.000
E00.2 Congenital iodine-deficiency syndrome, mixed type	0.044	0.956	0.000
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type	0.044	0.956	0.000
E00.0 Congenital iodine-deficiency syndrome, neurological type	0.044	0.956	0.000
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions	0.044	0.956	0.000
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified	0.044	0.956	0.000
E01.1 Iodine-deficiency-related multinodular (endemic) goitre	0.044	0.956	0.000
E01.0 Iodine-deficiency-related diffuse (endemic) goitre	0.044	0.956	0.000
E53.1 Pyridoxine deficiency	0.044	0.956	0.000
E53.0 Riboflavin deficiency	0.044	0.956	0.000
E53.9 Vitamin B deficiency, unspecified	0.043	0.956	0.000
K73 Chronic hepatitis, not elsewhere classified	0.043	0.957	0.000
K75.2 Nonspecific reactive hepatitis	0.043	0.957	0.000
K75.1 Phlebitis of portal vein	0.043	0.957	0.000
K70.1 Alcoholic hepatitis	0.043	0.957	0.000
K71.1 Toxic liver disease with hepatic necrosis	0.042	0.958	0.000
K75.9 Inflammatory liver disease, unspecified	0.042	0.958	0.000
E05.5 Thyroid crisis or storm	0.040	0.959	0.000
E05.4 Thyrotoxicosis factitia	0.040	0.959	0.000
E05.3 Thyrotoxicosis from ectopic thyroid tissue	0.040	0.959	0.000
E05.1 Thyrotoxicosis with toxic single thyroid nodule	0.040	0.959	0.000
E55 Vitamin D deficiency	0.040	0.960	0.000
E04.8 Other specified non-toxic goitre	0.039	0.961	0.000
E67.8 Other specified hyperalimentation	0.038	0.962	0.000
E67.3 Hypervitaminosis D	0.038	0.962	0.000
E67.2 Megavitamin-B6 syndrome	0.038	0.962	0.000
E67.1 Hypercarotenaemia	0.038	0.962	0.000
E67.0 Hypervitaminosis A	0.038	0.962	0.000
K71.9 Toxic liver disease, unspecified	0.038	0.962	0.000
K71.8 Toxic liver disease with other disorders of liver	0.038	0.962	0.000
K71.7 Toxic liver disease with fibrosis and cirrhosis of liver	0.038	0.962	0.000
K71.6 Toxic liver disease with hepatitis, not elsewhere classified	0.038	0.962	0.000
K71.5 Toxic liver disease with chronic active hepatitis	0.038	0.962	0.000
K71.4 Toxic liver disease with chronic lobular hepatitis	0.038	0.962	0.000
K71.3 Toxic liver disease with chronic persistent hepatitis	0.038	0.962	0.000
K71.2 Toxic liver disease with acute hepatitis	0.038	0.962	0.000
K71.0 Toxic liver disease with cholestasis	0.038	0.962	0.000
E07 Other disorders of thyroid	0.038	0.962	0.000
E04.0 Non-toxic diffuse goitre	0.037	0.963	0.000
E44.1 Mild protein-energy malnutrition	0.037	0.963	0.000
E44.0 Moderate protein-energy malnutrition	0.037	0.963	0.000
E61 Deficiency of other nutrient elements	0.036	0.963	0.000
E50.9 Vitamin A deficiency, unspecified	0.036	0.964	0.000
E50.8 Other manifestations of vitamin A deficiency	0.036	0.964	0.000
E50.7 Other ocular manifestations of vitamin A deficiency	0.036	0.964	0.000
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea	0.036	0.964	0.000
E50.5 Vitamin A deficiency with night blindness	0.036	0.964	0.000
E50.4 Vitamin A deficiency with keratomalacia	0.036	0.964	0.000
E50.3 Vitamin A deficiency with corneal ulceration and xerosis	0.036	0.964	0.000
E50.2 Vitamin A deficiency with corneal xerosis	0.036	0.964	0.000
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis	0.036	0.964	0.000
E50.0 Vitamin A deficiency with conjunctival xerosis	0.036	0.964	0.000
E51.9 Thiamine deficiency, unspecified	0.036	0.964	0.000
E51.8 Other manifestations of thiamine deficiency	0.036	0.964	0.000
E51.2 Wernicke's encephalopathy	0.036	0.964	0.000
E51.1 Beriberi	0.036	0.964	0.000
E56.9 Vitamin deficiency, unspecified	0.036	0.964	0.000
E56.8 Deficiency of other vitamins	0.036	0.964	0.000
E56.1 Deficiency of vitamin K	0.036	0.964	0.000
E56.0 Deficiency of vitamin E	0.036	0.964	0.000
E63.9 Nutritional deficiency, unspecified	0.036	0.964	0.000
E63.8 Other specified nutritional deficiencies	0.036	0.964	0.000
E63.1 Imbalance of constituents of food intake	0.036	0.964	0.000
E63.0 Essential fatty acid [EFA] deficiency	0.036	0.964	0.000
E64.9 Sequelae of unspecified nutritional deficiency	0.036	0.964	0.000
E64.8 Sequelae of other nutritional deficiencies	0.036	0.964	0.000
E64.3 Sequelae of rickets	0.036	0.964	0.000
E64.2 Sequelae of vitamin C deficiency	0.036	0.964	0.000
E64.1 Sequelae of vitamin A deficiency	0.036	0.964	0.000
E64.0 Sequelae of protein-energy malnutrition	0.036	0.964	0.000
E05.8 Other thyrotoxicosis	0.035	0.965	0.000
E05.2 Thyrotoxicosis with toxic multinodular goitre	0.035	0.965	0.000
K77.8 Liver disorders in other diseases classified elsewhere	0.034	0.966	0.000
K77.0 Liver disorders in infectious and parasitic diseases classified elsewhere	0.034	0.966	0.000
K76.9 Liver disease, unspecified	0.034	0.966	0.000
E15 Nondiabetic hypoglycaemic coma	0.033	0.967	0.000
E66 Obesity	0.031	0.969	0.000
K73.8 Other chronic hepatitis, not elsewhere classified	0.031	0.969	0.000
K73.1 Chronic lobular hepatitis, not elsewhere classified	0.031	0.969	0.000
K73.0 Chronic persistent hepatitis, not elsewhere classified	0.031	0.969	0.000
K73.2 Chronic active hepatitis, not elsewhere classified	0.030	0.970	0.000
I83 Varicose veins of lower extremities	0.030	0.970	0.000
E20-E35 Disorders of other endocrine glands	0.029	0.970	0.000
M16.1 Other primary coxarthrosis	0.029	0.971	0.000
E87 Other disorders of fluid, electrolyte and acid-base balance	0.029	0.971	0.000
E55.0 Rickets, active	0.029	0.971	0.000
K73.9 Chronic hepatitis, unspecified	0.029	0.971	0.000
E04.9 Non-toxic goitre, unspecified	0.028	0.972	0.000
E66.2 Extreme obesity with alveolar hypoventilation	0.028	0.972	0.000
E05.0 Thyrotoxicosis with diffuse goitre	0.028	0.972	0.000
E61.2 Magnesium deficiency	0.027	0.972	0.000
K72 Hepatic failure, not elsewhere classified	0.028	0.972	0.000
E07.1 Dyshormogenetic goitre	0.027	0.973	0.000
E07.0 Hypersecretion of calcitonin	0.027	0.973	0.000
E87.5 Hyperkalaemia	0.027	0.973	0.000
F10.1 Harmful use	0.027	0.973	0.000
E61.9 Deficiency of nutrient element, unspecified	0.026	0.973	0.000
E61.8 Deficiency of other specified nutrient elements	0.026	0.973	0.000
E61.7 Deficiency of multiple nutrient elements	0.026	0.973	0.000
E61.6 Vanadium deficiency	0.026	0.973	0.000
E61.5 Molybdenum deficiency	0.026	0.973	0.000
E61.4 Chromium deficiency	0.026	0.973	0.000
E61.3 Manganese deficiency	0.026	0.973	0.000
E61.0 Copper deficiency	0.026	0.973	0.000
I83.0 Varicose veins of lower extremities with ulcer	0.026	0.974	0.000
E34 Other endocrine disorders	0.026	0.974	0.000
E27 Other disorders of adrenal gland	0.025	0.975	0.000
E25 Adrenogenital disorders	0.024	0.976	0.000
K75.4 Autoimmune hepatitis	0.023	0.977	0.000
I83.2 Varicose veins of lower extremities with both ulcer and inflammation	0.023	0.977	0.000
E26 Hyperaldosteronism	0.023	0.977	0.000
E66.1 Drug-induced obesity	0.023	0.977	0.000
T78.2 Anaphylactic shock, unspecified	0.023	0.977	0.000
E27.1 Primary adrenocortical insufficiency	0.022	0.978	0.000
E66.0 Obesity due to excess calories	0.022	0.978	0.000
E34.9 Endocrine disorder, unspecified	0.022	0.978	0.000
E07.8 Other specified disorders of thyroid	0.021	0.978	0.000
E35 Disorders of endocrine glands in diseases classified elsewhere	0.021	0.979	0.000
E32 Diseases of thymus	0.021	0.979	0.000
E31 Polyglandular dysfunction	0.021	0.979	0.000
E30 Disorders of puberty, not elsewhere classified	0.021	0.979	0.000
E34.0 Carcinoid syndrome	0.021	0.979	0.000
E20 Hypoparathyroidism	0.021	0.979	0.000
E87.4 Mixed disorder of acid-base balance	0.021	0.979	0.000
E27.8 Other specified disorders of adrenal gland	0.021	0.979	0.000
E86 Volume depletion	0.021	0.979	0.000
K72.1 Chronic hepatic failure	0.020	0.980	0.000
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency	0.019	0.980	0.000
E27.2 Addisonian crisis	0.019	0.981	0.000
E87.8 Other disorders of electrolyte and fluid balance, not elsewhere classified	0.019	0.981	0.000
E55.9 Vitamin D deficiency, unspecified	0.019	0.981	0.000
E34.5 Androgen resistance syndrome	0.019	0.981	0.000
E34.4 Constitutional tall stature	0.019	0.981	0.000
E34.3 Short stature, not elsewhere classified	0.019	0.981	0.000
E34.2 Ectopic hormone secretion, not elsewhere classified	0.019	0.981	0.000
E34.1 Other hypersecretion of intestinal hormones	0.019	0.981	0.000
E24 Cushing's syndrome	0.019	0.981	0.000
E04.1 Non-toxic single thyroid nodule	0.019	0.981	0.000
E27.3 Drug-induced adrenocortical insufficiency	0.019	0.981	0.000
E87.7 Fluid overload	0.019	0.981	0.000
E34.8 Other specified endocrine disorders	0.018	0.981	0.000
E28 Ovarian dysfunction	0.018	0.981	0.000
E27.5 Adrenomedullary hyperfunction	0.018	0.982	0.000
E27.0 Other adrenocortical overactivity	0.018	0.982	0.000
E26.0 Primary hyperaldosteronism	0.018	0.982	0.000
E87.3 Alkalosis	0.018	0.982	0.000
T78 Adverse effects, not elsewhere classified	0.018	0.982	0.000
E25.9 Adrenogenital disorder, unspecified	0.017	0.983	0.000
E25.8 Other adrenogenital disorders	0.017	0.983	0.000
E29 Testicular dysfunction	0.017	0.983	0.000
E26.9 Hyperaldosteronism, unspecified	0.017	0.983	0.000
E26.8 Other hyperaldosteronism	0.017	0.983	0.000
E26.1 Secondary hyperaldosteronism	0.017	0.983	0.000
T78.3 Angioneurotic oedema	0.016	0.984	0.000
E27.4 Other and unspecified adrenocortical insufficiency	0.016	0.984	0.000
E30.9 Disorder of puberty, unspecified	0.015	0.984	0.000
E30.8 Other disorders of puberty	0.015	0.984	0.000
E30.1 Precocious puberty	0.015	0.984	0.000
E30.0 Delayed puberty	0.015	0.984	0.000
E31.9 Polyglandular dysfunction, unspecified	0.015	0.984	0.000
E31.8 Other polyglandular dysfunction	0.015	0.984	0.000
E31.1 Polyglandular hyperfunction	0.015	0.984	0.000
E31.0 Autoimmune polyglandular failure	0.015	0.984	0.000
E32.9 Disease of thymus, unspecified	0.015	0.984	0.000
E32.8 Other diseases of thymus	0.015	0.984	0.000
E32.1 Abscess of thymus	0.015	0.984	0.000
E32.0 Persistent hyperplasia of thymus	0.015	0.984	0.000
E35.8 Disorders of other endocrine glands in diseases classified elsewhere	0.015	0.984	0.000
E35.1 Disorders of adrenal glands in diseases classified elsewhere	0.015	0.984	0.000
E35.0 Disorders of thyroid gland in diseases classified elsewhere	0.015	0.984	0.000
E20.8 Other hypoparathyroidism	0.015	0.984	0.000
E20.1 Pseudohypoparathyroidism	0.015	0.984	0.000
E20.0 Idiopathic hypoparathyroidism	0.015	0.984	0.000
E28.3 Primary ovarian failure	0.015	0.984	0.000
E07.9 Disorder of thyroid, unspecified	0.015	0.984	0.000
E20.9 Hypoparathyroidism, unspecified	0.015	0.985	0.000
T78.0 Anaphylactic shock due to adverse food reaction	0.015	0.985	0.000
F10 Mental and behavioural disorders due to use of alcohol	0.015	0.985	0.000
H52.2 Astigmatism	0.015	0.985	0.000
I71.4 Abdominal aortic aneurysm, without mention of rupture	0.014	0.986	0.000
E27.9 Disorder of adrenal gland, unspecified	0.014	0.986	0.000
F10.5 Psychotic disorder	0.014	0.986	0.000
E24.8 Other Cushing's syndrome	0.013	0.986	0.000
E24.4 Alcohol-induced pseudo-Cushing's syndrome	0.013	0.986	0.000
E24.3 Ectopic ACTH syndrome	0.013	0.986	0.000
E24.2 Drug-induced Cushing's syndrome	0.013	0.986	0.000
E24.1 Nelson's syndrome	0.013	0.986	0.000
E24.0 Pituitary-dependent Cushing's disease	0.013	0.986	0.000
M16 Coxarthrosis [arthrosis of hip]	0.014	0.986	0.000
E28.9 Ovarian dysfunction, unspecified	0.013	0.986	0.000
E28.8 Other ovarian dysfunction	0.013	0.986	0.000
E28.1 Androgen excess	0.013	0.986	0.000
E28.0 Oestrogen excess	0.013	0.986	0.000
K72.9 Hepatic failure, unspecified	0.013	0.987	0.000
K72.0 Acute and subacute hepatic failure	0.013	0.987	0.000
E87.0 Hyperosmolality and hypernatraemia	0.013	0.987	0.000
T78.9 Adverse effect, unspecified	0.013	0.987	0.000
M16.3 Other dysplastic coxarthrosis	0.013	0.987	0.000
E16 Other disorders of pancreatic internal secretion	0.012	0.987	0.000
K74 Fibrosis and cirrhosis of liver	0.012	0.987	0.000
T78.8 Other adverse effects, not elsewhere classified	0.013	0.987	0.000
F10.2 Dependence syndrome	0.013	0.987	0.000
E29.9 Testicular dysfunction, unspecified	0.012	0.988	0.000
E29.8 Other testicular dysfunction	0.012	0.988	0.000
E29.0 Testicular hyperfunction	0.012	0.988	0.000
M75.4 Impingement syndrome of shoulder	0.000	0.988	0.012
M16.5 Other posttraumatic coxarthrosis	0.012	0.988	0.000
T78.1 Other adverse food reactions, not elsewhere classified	0.012	0.988	0.000
E22 Hyperfunction of pituitary gland	0.011	0.988	0.000
F10.9 Unspecified mental and behavioural disorder	0.011	0.989	0.000
E24.9 Cushing's syndrome, unspecified	0.011	0.989	0.000
M75.1 Rotator cuff syndrome	0.000	0.989	0.011
T78.4 Allergy, unspecified	0.011	0.989	0.000
F10.8 Other mental and behavioural disorders	0.011	0.989	0.000
F10.7 Residual and late-onset psychotic disorder	0.011	0.989	0.000
I83.1 Varicose veins of lower extremities with inflammation	0.011	0.989	0.000
E23 Hypofunction and other disorders of pituitary gland	0.010	0.989	0.000
F10.4 Withdrawal state with delirium	0.010	0.989	0.000
M16.2 Coxarthrosis resulting from dysplasia, bilateral	0.010	0.990	0.000
M75 Shoulder lesions	0.000	0.990	0.010
M16.6 Other secondary coxarthrosis, bilateral	0.010	0.990	0.000
M16.4 Posttraumatic coxarthrosis, bilateral	0.010	0.990	0.000
M16.7 Other secondary coxarthrosis	0.010	0.990	0.000
E61.1 Iron deficiency	0.009	0.990	0.001
F10.6 Amnesic syndrome	0.010	0.990	0.000
I71 Aortic aneurysm and dissection	0.010	0.990	0.000
E78 Disorders of lipoprotein metabolism and other lipidaemias	0.010	0.990	0.000
E16.9 Disorder of pancreatic internal secretion, unspecified	0.009	0.991	0.000
E16.8 Other specified disorders of pancreatic internal secretion	0.009	0.991	0.000
E16.4 Abnormal secretion of gastrin	0.009	0.991	0.000
E16.3 Increased secretion of glucagon	0.009	0.991	0.000
K74.4 Secondary biliary cirrhosis	0.009	0.991	0.000
K74.2 Hepatic fibrosis with hepatic sclerosis	0.009	0.991	0.000
K74.1 Hepatic sclerosis	0.009	0.991	0.000
M75.0 Adhesive capsulitis of shoulder	0.000	0.991	0.009
I77.1 Stricture of artery	0.009	0.991	0.000
T66-T78 Other and unspecified effects of external causes	0.009	0.991	0.000
K74.0 Hepatic fibrosis	0.009	0.991	0.000
E22.9 Hyperfunction of pituitary gland, unspecified	0.008	0.991	0.000
E22.8 Other hyperfunction of pituitary gland	0.008	0.991	0.000
E21 Hyperparathyroidism and other disorders of parathyroid gland	0.008	0.991	0.000
E87.2 Acidosis	0.009	0.991	0.000
M75.3 Calcific tendinitis of shoulder	0.000	0.991	0.009
Z87.8 Personal history of other specified conditions	0.008	0.992	0.000
C18.7 Sigmoid colon	0.000	0.992	0.008
I80-I89 Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified	0.008	0.992	0.000
E16.1 Other hypoglycaemia	0.008	0.992	0.000
I77 Other disorders of arteries and arterioles	0.008	0.992	0.000
E29.1 Testicular hypofunction	0.008	0.992	0.000
Z42.1 Follow-up care involving plastic surgery of breast	0.000	0.992	0.008
I71.3 Abdominal aortic aneurysm, ruptured	0.008	0.992	0.000
E23.3 Hypothalamic dysfunction, not elsewhere classified	0.008	0.992	0.000
E23.1 Drug-induced hypopituitarism	0.008	0.992	0.000
E23.7 Disorder of pituitary gland, unspecified	0.008	0.992	0.000
E22.0 Acromegaly and pituitary gigantism	0.007	0.992	0.000
I77.9 Disorder of arteries and arterioles, unspecified	0.008	0.992	0.000
E23.6 Other disorders of pituitary gland	0.007	0.992	0.000
M75.8 Other shoulder lesions	0.000	0.992	0.008
T66 Unspecified effects of radiation	0.008	0.992	0.000
I70-I79 Diseases of arteries, arterioles and capillaries	0.008	0.992	0.000
I88 Nonspecific lymphadenitis	0.007	0.992	0.000
O99.0 Anaemia complicating pregnancy, childbirth and the puerperium	0.000	0.992	0.008
E78.6 Lipoprotein deficiency	0.007	0.993	0.000
E66.8 Other obesity	0.007	0.993	0.000
E78.8 Other disorders of lipoprotein metabolism	0.007	0.993	0.000
I87 Other disorders of veins	0.007	0.993	0.000
F10-F19 Mental and behavioural disorders due to psychoactive substance use	0.007	0.993	0.000
I71.8 Aortic aneurysm of unspecified site, ruptured	0.007	0.993	0.000
I71.6 Thoracoabdominal aortic aneurysm, without mention of rupture	0.007	0.993	0.000
I71.5 Thoracoabdominal aortic aneurysm, ruptured	0.007	0.993	0.000
I71.1 Thoracic aortic aneurysm, ruptured	0.007	0.993	0.000
M16.0 Primary coxarthrosis, bilateral	0.007	0.993	0.000
E78.3 Hyperchylomicronaemia	0.007	0.993	0.000
I71.2 Thoracic aortic aneurysm, without mention of rupture	0.007	0.993	0.000
T75 Effects of other external causes	0.007	0.993	0.000
I87.8 Other specified disorders of veins	0.007	0.993	0.000
T68 Hypothermia	0.007	0.993	0.000
E66.9 Obesity, unspecified	0.007	0.993	0.000
E16.0 Drug-induced hypoglycaemia without coma	0.006	0.993	0.001
F10.3 Withdrawal state	0.007	0.993	0.000
T74 Maltreatment syndromes	0.007	0.993	0.000
T73 Effects of other deprivation	0.007	0.993	0.000
T69 Other effects of reduced temperature	0.007	0.993	0.000
T67 Effects of heat and light	0.007	0.993	0.000
I88.0 Nonspecific mesenteric lymphadenitis	0.007	0.993	0.000
I72 Other aneurysm	0.007	0.993	0.000
T71 Asphyxiation	0.007	0.993	0.000
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone	0.006	0.993	0.000
K74.5 Biliary cirrhosis, unspecified	0.006	0.993	0.001
I85 Oesophageal varices	0.007	0.993	0.000
E21.5 Disorder of parathyroid gland, unspecified	0.006	0.993	0.000
E21.4 Other specified disorders of parathyroid gland	0.006	0.993	0.000
E21.2 Other hyperparathyroidism	0.006	0.993	0.000
I70 Atherosclerosis	0.006	0.993	0.000
I80 Phlebitis and thrombophlebitis	0.006	0.994	0.000
O99.8 Other specified diseases and conditions complicating pregnancy, childbirth and the puerperium	0.000	0.994	0.006
I70.20 Atherosclerosis of arteries of extremities (without gangrene)	0.006	0.994	0.000
I77.2 Rupture of artery	0.006	0.994	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations