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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs1667394
log Bayes Factor = 3.63476
Chromosome 15   position 28,530,182  (GRCh37) Explore rs1667394 on Ensembl!
Variant rs1667394 is listed in the   GWAS Catalog   ⇪

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
H40 Glaucoma
0.000 0.002 0.998
H40.9 Glaucoma, unspecified
0.000 0.004 0.996
H40.2 Primary angle-closure glaucoma
0.000 0.004 0.996
H26.9 Cataract, unspecified
0.000 0.020 0.980
H25 Senile cataract
0.000 0.028 0.972
H25-H28 Disorders of lens
0.000 0.029 0.971
H25.8 Other senile cataract
0.000 0.030 0.970
H26 Other cataract
0.000 0.031 0.969
H40.0 Glaucoma suspect
0.000 0.043 0.957
H25.1 Senile nuclear cataract
0.000 0.055 0.945
H40.1 Primary open-angle glaucoma
0.000 0.084 0.916
H40-H42 Glaucoma
0.000 0.090 0.910
Chapter VII Diseases of the eye and adnexa
0.000 0.153 0.847
H40.5 Glaucoma secondary to other eye disorders
0.000 0.227 0.773
H25.9 Senile cataract, unspecified
0.000 0.230 0.770
H40.4 Glaucoma secondary to eye inflammation
0.000 0.247 0.753
H40.6 Glaucoma secondary to drugs
0.000 0.253 0.747
H49-H52 Disorders of ocular muscles, binocular movement, accommodation and refraction
0.000 0.273 0.727
H49 Paralytic strabismus
0.000 0.309 0.691
H27 Other disorders of lens
0.000 0.328 0.672
H25.2 Senile cataract, morgagnian type
0.000 0.328 0.671
H26.0 Infantile, juvenile and presenile cataract
0.000 0.345 0.655
H42 Glaucoma in diseases classified elsewhere
0.000 0.347 0.652
H49.0 Third [oculomotor] nerve palsy
0.000 0.362 0.638
H28 Cataract and other disorders of lens in diseases classified elsewhere
0.000 0.362 0.638
H26.8 Other specified cataract
0.000 0.372 0.628
H53-H54 Visual disturbances and blindness
0.000 0.376 0.624
H40.3 Glaucoma secondary to eye trauma
0.000 0.377 0.623
H26.3 Drug-induced cataract
0.000 0.395 0.604
H49.1 Fourth [trochlear] nerve palsy
0.000 0.396 0.604
H26.2 Complicated cataract
0.000 0.411 0.589
H53.8 Other visual disturbances
0.000 0.431 0.569
H53 Visual disturbances
0.000 0.432 0.568
H26.1 Traumatic cataract
0.000 0.436 0.564
H40.8 Other glaucoma
0.000 0.442 0.557
H51 Other disorders of binocular movement
0.000 0.465 0.535
H27.0 Aphakia
0.000 0.476 0.524
H27.8 Other specified disorders of lens
0.000 0.492 0.508
H49.8 Other paralytic strabismus
0.000 0.496 0.504
H49.4 Progressive external ophthalmoplegia
0.000 0.496 0.504
H49.3 Total (external) ophthalmoplegia
0.000 0.505 0.495
H49.2 Sixth [abducent] nerve palsy
0.000 0.511 0.488
H27.9 Disorder of lens, unspecified
0.000 0.518 0.482
H42.8 Glaucoma in other diseases classified elsewhere
0.000 0.532 0.468
H42.0 Glaucoma in endocrine, nutritional and metabolic diseases
0.000 0.532 0.468
H28.8 Other disorders of lens in diseases classified elsewhere
0.000 0.542 0.457
H28.2 Cataract in other diseases classified elsewhere
0.000 0.542 0.457
H28.1 Cataract in other endocrine, nutritional and metabolic diseases
0.000 0.542 0.457
H49.9 Paralytic strabismus, unspecified
0.000 0.547 0.453
H53.5 Colour vision deficiencies
0.000 0.564 0.436
H51.2 Internuclear ophthalmoplegia
0.000 0.574 0.426
H15-H22 Disorders of sclera, cornea, iris and ciliary body
0.000 0.585 0.415
H53.6 Night blindness
0.000 0.593 0.407
H50 Other strabismus
0.000 0.593 0.407
H52 Disorders of refraction and accommodation
0.000 0.600 0.400
H28.0 Diabetic cataract
0.000 0.600 0.399
H53.3 Other disorders of binocular vision
0.000 0.604 0.396
H51.1 Convergence insufficiency and excess
0.000 0.616 0.384
H51.0 Palsy of conjugate gaze
0.000 0.616 0.384
H53.2 Diplopia
0.000 0.619 0.381
H46-H48 Disorders of optic nerve and visual pathways
0.001 0.626 0.373
H51.8 Other specified disorders of binocular movement
0.000 0.632 0.368
H51.9 Disorder of binocular movement, unspecified
0.000 0.636 0.363
H27.1 Dislocation of lens
0.000 0.648 0.351
H18 Other disorders of cornea
0.000 0.654 0.346
H53.9 Visual disturbance, unspecified
0.000 0.656 0.344
H52.3 Anisometropia and aniseikonia
0.000 0.663 0.337
H53.4 Visual field defects
0.000 0.664 0.336
H18.5 Hereditary corneal dystrophies
0.000 0.674 0.326
H50.8 Other specified strabismus
0.000 0.681 0.318
H50.0 Convergent concomitant strabismus
0.000 0.688 0.312
H50.3 Intermittent heterotropia
0.000 0.696 0.304
H16 Keratitis
0.000 0.697 0.303
H52.1 Myopia
0.000 0.704 0.296
H50.4 Other and unspecified heterotropia
0.000 0.705 0.295
H19 Disorders of sclera and cornea in diseases classified elsewhere
0.000 0.709 0.290
H22 Disorders of iris and ciliary body in diseases classified elsewhere
0.000 0.712 0.288
H52.6 Other disorders of refraction
0.000 0.713 0.287
H52.5 Disorders of accommodation
0.000 0.713 0.287
H50.2 Vertical strabismus
0.000 0.713 0.287
H50.6 Mechanical strabismus
0.000 0.715 0.285
H15 Disorders of sclera
0.000 0.717 0.283
H18.9 Disorder of cornea, unspecified
0.000 0.721 0.279
H55-H59 Other disorders of eye and adnexa
0.001 0.726 0.273
H50.1 Divergent concomitant strabismus
0.000 0.728 0.272
H10-H13 Disorders of conjunctiva
0.001 0.729 0.270
H50.5 Heterophoria
0.000 0.729 0.271
H17 Corneal scars and opacities
0.000 0.733 0.266
H52.4 Presbyopia
0.000 0.737 0.263
H18.3 Changes in corneal membranes
0.000 0.738 0.262
H48 Disorders of optic [2nd] nerve and visual pathways in diseases classified elsewhere
0.001 0.738 0.261
H18.4 Corneal degeneration
0.000 0.741 0.259
H52.7 Disorder of refraction, unspecified
0.000 0.744 0.256
H18.7 Other corneal deformities
0.000 0.744 0.255
H52.2 Astigmatism
0.000 0.745 0.255
H20 Iridocyclitis
0.000 0.747 0.253
H26.4 After-cataract
0.000 0.748 0.252
H18.0 Corneal pigmentations and deposits
0.000 0.748 0.251
H18.2 Other corneal oedema
0.000 0.752 0.248
H43-H45 Disorders of vitreous body and globe
0.000 0.756 0.243
H16.2 Keratoconjunctivitis
0.000 0.772 0.228
H16.3 Interstitial and deep keratitis
0.000 0.776 0.224
H16.0 Corneal ulcer
0.000 0.776 0.224
H15.0 Scleritis
0.000 0.777 0.222
H18.1 Bullous keratopathy
0.000 0.779 0.220
H16.4 Corneal neovascularisation
0.000 0.785 0.215
H16.9 Keratitis, unspecified
0.000 0.785 0.214
H16.1 Other superficial keratitis without conjunctivitis
0.000 0.786 0.214
H47 Other disorders of optic [2nd] nerve and visual pathways
0.001 0.788 0.210
H19.2 Keratitis and keratoconjunctivitis in other infectious and parasitic diseases classified elsewhere
0.000 0.791 0.209
H19.8 Other disorders of sclera and cornea in diseases classified elsewhere
0.000 0.791 0.208
H19.0 Scleritis and episcleritis in diseases classified elsewhere
0.000 0.791 0.208
H19.3 Keratitis and keratoconjunctivitis in other diseases classified elsewhere
0.000 0.793 0.207
H22.8 Other disorders of iris and ciliary body in diseases classified elsewhere
0.000 0.793 0.207
H22.0 Iridocyclitis in infectious and parasitic diseases classified elsewhere
0.000 0.793 0.207
H15.9 Disorder of sclera, unspecified
0.000 0.794 0.206
H55 Nystagmus and other irregular eye movements
0.000 0.796 0.204
H16.8 Other keratitis
0.000 0.796 0.204
H13 Disorders of conjunctiva in diseases classified elsewhere
0.001 0.798 0.201
H19.1 Herpesviral keratitis and keratoconjunctivitis
0.000 0.798 0.202
H22.1 Iridocyclitis in other diseases classified elsewhere
0.000 0.803 0.197
H20.0 Acute and subacute iridocyclitis
0.000 0.804 0.196
H15.8 Other disorders of sclera
0.000 0.806 0.194
H30-H36 Disorders of choroid and retina
0.000 0.807 0.193
H17.8 Other corneal scars and opacities
0.000 0.807 0.193
H17.1 Other central corneal opacity
0.000 0.809 0.191
H17.0 Adherent leukoma
0.000 0.809 0.191
H48.8 Other disorders of optic nerve and visual pathways in diseases classified elsewhere
0.001 0.812 0.187
H48.0 Optic atrophy in diseases classified elsewhere
0.001 0.812 0.187
H47.2 Optic atrophy
0.001 0.817 0.183
H20.8 Other iridocyclitis
0.000 0.818 0.182
H20.2 Lens-induced iridocyclitis
0.000 0.819 0.181
H48.1 Retrobulbar neuritis in diseases classified elsewhere
0.001 0.819 0.180
H53.0 Amblyopia ex anopsia
0.000 0.821 0.179
H45 Disorders of vitreous body and globe in diseases classified elsewhere
0.000 0.826 0.173
H21 Other disorders of iris and ciliary body
0.000 0.830 0.170
H52.0 Hypermetropia
0.000 0.832 0.168
H46 Optic neuritis
0.001 0.832 0.167
H15.1 Episcleritis
0.000 0.833 0.167
H58 Other disorders of eye and adnexa in diseases classified elsewhere
0.001 0.835 0.164
H20.1 Chronic iridocyclitis
0.000 0.836 0.164
H53.1 Subjective visual disturbances
0.000 0.836 0.163
H13.3 Ocular pemphigoid
0.001 0.839 0.160
H31 Other disorders of choroid
0.000 0.840 0.160
H17.9 Corneal scar and opacity, unspecified
0.000 0.842 0.158
H18.6 Keratoconus
0.001 0.842 0.157
H47.7 Disorder of visual pathways, unspecified
0.001 0.848 0.151
H47.6 Disorders of visual cortex
0.001 0.848 0.151
H47.4 Disorders of optic chiasm
0.001 0.848 0.151
H47.1 Papilloedema, unspecified
0.001 0.851 0.149
H30 Chorioretinal inflammation
0.000 0.851 0.149
H34 Retinal vascular occlusions
0.000 0.851 0.149
H13.8 Other disorders of conjunctiva in diseases classified elsewhere
0.001 0.855 0.144
H13.2 Conjunctivitis in other diseases classified elsewhere
0.001 0.855 0.144
H13.0 Filarial infection of conjunctiva
0.001 0.855 0.144
H31.8 Other specified disorders of choroid
0.000 0.856 0.144
H47.5 Disorders of other visual pathways
0.001 0.856 0.143
H32 Chorioretinal disorders in diseases classified elsewhere
0.000 0.861 0.139
H20.9 Iridocyclitis, unspecified
0.000 0.867 0.133
H13.1 Conjunctivitis in infectious and parasitic diseases classified elsewhere
0.001 0.867 0.132
H18.8 Other specified disorders of cornea
0.001 0.867 0.132
H50.9 Strabismus, unspecified
0.000 0.868 0.131
H21.9 Disorder of iris and ciliary body, unspecified
0.000 0.870 0.129
H47.0 Disorders of optic nerve, not elsewhere classified
0.001 0.873 0.126
H45.8 Other disorders of vitreous body and globe in diseases classified elsewhere
0.000 0.875 0.124
H45.1 Endophthalmitis in diseases classified elsewhere
0.000 0.875 0.124
H54 Blindness and low vision
0.001 0.875 0.124
H45.0 Vitreous haemorrhage in diseases classified elsewhere
0.000 0.876 0.123
H21.2 Degeneration of iris and ciliary body
0.000 0.877 0.122
H21.3 Cyst of iris, ciliary body and anterior chamber
0.000 0.878 0.122
H21.4 Pupillary membranes
0.000 0.878 0.122
H30.9 Chorioretinal inflammation, unspecified
0.000 0.878 0.122
H57 Other disorders of eye and adnexa
0.001 0.879 0.120
H34.1 Central retinal artery occlusion
0.000 0.881 0.119
H58.9 Other specified disorders of eye and adnexa in diseases classified elsewhere
0.001 0.882 0.118
H58.1 Visual disturbances in diseases classified elsewhere
0.001 0.882 0.118
H58.0 Anomalies of pupillary function in diseases classified elsewhere
0.001 0.882 0.118
H34.2 Other retinal artery occlusions
0.000 0.883 0.117
H10 Conjunctivitis
0.001 0.883 0.116
H21.1 Other vascular disorders of iris and ciliary body
0.000 0.883 0.116
H21.0 Hyphaema
0.000 0.884 0.116
H31.4 Choroidal detachment
0.000 0.885 0.115
H31.2 Hereditary choroidal dystrophy
0.000 0.885 0.115
H31.9 Disorder of choroid, unspecified
0.000 0.886 0.114
H31.1 Choroidal degeneration
0.000 0.889 0.111
H59 Postprocedural disorders of eye and adnexa, not elsewhere classified
0.002 0.890 0.108
H34.9 Retinal vascular occlusion, unspecified
0.000 0.890 0.110
H31.3 Choroidal haemorrhage and rupture
0.000 0.890 0.109
H30.8 Other chorioretinal inflammations
0.000 0.893 0.107
H30.1 Disseminated chorioretinal inflammation
0.000 0.893 0.107
H30.0 Focal chorioretinal inflammation
0.000 0.893 0.107
H34.0 Transient retinal artery occlusion
0.000 0.893 0.107
H31.0 Chorioretinal scars
0.000 0.895 0.105
H54.6 Unqualified visual loss, one eye
0.000 0.900 0.100
H32.8 Other chorioretinal disorders in diseases classified elsewhere
0.000 0.900 0.100
H32.0 Chorioretinal inflammation in infectious and parasitic diseases classified elsewhere
0.000 0.900 0.100
H30.2 Posterior cyclitis
0.000 0.900 0.099
H54.5 Low vision, one eye
0.000 0.905 0.095
H54.3 Unqualified visual loss, both eyes
0.001 0.907 0.092
H54.1 Blindness, one eye, low vision, other eye
0.001 0.907 0.092
H57.0 Anomalies of pupillary function
0.000 0.908 0.092
H21.8 Other specified disorders of iris and ciliary body
0.001 0.909 0.090
H10.0 Mucopurulent conjunctivitis
0.001 0.912 0.087
H54.2 Low vision, both eyes
0.001 0.913 0.086
H58.8 Visual disturbances in diseases classified elsewhere
0.001 0.913 0.086
H34.8 Other retinal vascular occlusions
0.000 0.915 0.085
H36 Retinal disorders in diseases classified elsewhere
0.000 0.915 0.085
H10.2 Other acute conjunctivitis
0.001 0.916 0.083
H10.5 Blepharoconjunctivitis
0.001 0.918 0.081
H10.1 Acute atopic conjunctivitis
0.001 0.918 0.081
H57.1 Ocular pain
0.000 0.918 0.081
H10.8 Other conjunctivitis
0.001 0.920 0.079
H59.0 Vitreous syndrome following cataract surgery
0.001 0.920 0.078
H10.3 Acute conjunctivitis, unspecified
0.001 0.922 0.077
H10.4 Chronic conjunctivitis
0.001 0.924 0.075
H44 Disorders of globe
0.001 0.926 0.073
H54.4 Blindness, one eye
0.000 0.927 0.072
H21.5 Other adhesions and disruptions of iris and ciliary body
0.001 0.929 0.071
H43 Disorders of vitreous body
0.000 0.929 0.071
H59.9 Postprocedural disorder of eye and adnexa, unspecified
0.002 0.936 0.062
H47.3 Other disorders of optic disk
0.002 0.936 0.062
H36.8 Other retinal disorders in diseases classified elsewhere
0.000 0.939 0.061
H57.9 Disorder of eye and adnexa, unspecified
0.001 0.940 0.059
H57.8 Other specified disorders of eye and adnexa
0.001 0.943 0.056
H43.0 Vitreous prolapse
0.000 0.943 0.056
H44.9 Disorder of globe, unspecified
0.000 0.946 0.053
H44.6 Retained (old) intraocular foreign body, magnetic
0.001 0.947 0.053
H44.3 Other degenerative disorders of globe
0.001 0.947 0.053
H10.9 Conjunctivitis, unspecified
0.001 0.947 0.051
H44.7 Retained (old) intraocular foreign body, nonmagnetic
0.001 0.948 0.052
H54.0 Blindness, both eyes
0.001 0.948 0.051
H44.1 Other endophthalmitis
0.001 0.949 0.050
H43.2 Crystalline deposits in vitreous body
0.000 0.950 0.050
H43.8 Other disorders of vitreous body
0.000 0.951 0.049
H44.8 Other disorders of globe
0.001 0.951 0.049
H00-H06 Disorders of eyelid, lacrimal system and orbit
0.003 0.953 0.044
H11 Other disorders of conjunctiva
0.001 0.954 0.044
H44.2 Degenerative myopia
0.000 0.955 0.045
H44.4 Hypotony of eye
0.001 0.955 0.044
H44.5 Degenerated conditions of globe
0.001 0.956 0.044
H43.9 Disorder of vitreous body, unspecified
0.000 0.958 0.042
H44.0 Purulent endophthalmitis
0.001 0.959 0.041
H54.9 Unspecified visual impairment (binocular)
0.001 0.960 0.039
H03 Disorders of eyelid in diseases classified elsewhere
0.002 0.965 0.033
H11.2 Conjunctival scars
0.001 0.966 0.033
H11.9 Disorder of conjunctiva, unspecified
0.001 0.966 0.033
H25.0 Senile incipient cataract
0.001 0.967 0.032
H54.7 Unspecified visual loss
0.001 0.967 0.032
H43.3 Other vitreous opacities
0.000 0.968 0.032
H00 Hordeolum and chalazion
0.002 0.968 0.030
H11.1 Conjunctival degenerations and deposits
0.001 0.969 0.030
H59.8 Other postprocedural disorders of eye and adnexa
0.003 0.970 0.027
H33 Retinal detachments and breaks
0.000 0.972 0.028
H00.0 Hordeolum and other deep inflammation of eyelid
0.001 0.972 0.027
H03.1 Involvement of eyelid in other infectious diseases classified elsewhere
0.001 0.972 0.026
H06 Disorders of lachrymal system and orbit in diseases classified elsewhere
0.003 0.973 0.024
H01 Other inflammation of eyelid
0.002 0.974 0.023
H03.0 Parasitic infestation of eyelid in diseases classified elsewhere
0.002 0.975 0.024
H11.3 Conjunctival haemorrhage
0.001 0.975 0.024
H33.1 Retinoschisis and retinal cysts
0.000 0.976 0.024
H11.0 Pterygium
0.001 0.977 0.022
H03.8 Involvement of eyelid in other diseases classified elsewhere
0.002 0.977 0.021
H01.9 Inflammation of eyelid, unspecified
0.001 0.978 0.021
H11.8 Other specified disorders of conjunctiva
0.002 0.980 0.018
H33.4 Traction detachment of retina
0.000 0.980 0.020
H05 Disorders of orbit
0.003 0.980 0.017
H06.3 Other disorders of orbit in diseases classified elsewhere
0.002 0.981 0.017
H06.1 Parasitic infestation of orbit in diseases classified elsewhere
0.002 0.981 0.017
H06.0 Disorders of lachrymal system in diseases classified elsewhere
0.002 0.981 0.017
H04 Disorders of lachrymal system
0.000 0.982 0.018
H43.1 Vitreous haemorrhage
0.000 0.982 0.017
M75.4 Impingement syndrome of shoulder
0.017 0.983 0.000
H01.1 Non-infectious dermatoses of eyelid
0.002 0.983 0.015
H33.2 Serous retinal detachment
0.000 0.983 0.017
H04.9 Disorder of lachrymal system, unspecified
0.000 0.984 0.015
H11.4 Other conjunctival vascular disorders and cysts
0.002 0.985 0.014
H01.8 Other specified inflammation of eyelid
0.002 0.985 0.013
H04.2 Epiphora
0.000 0.985 0.014
H05.5 Retained (old) foreign body following penetrating wound of orbit
0.002 0.986 0.013
H05.4 Enophthalmos
0.002 0.986 0.013
H05.8 Other disorders of orbit
0.002 0.986 0.013
H05.3 Deformity of orbit
0.002 0.986 0.012
H04.0 Dacryoadenitis
0.000 0.986 0.013
H05.1 Chronic inflammatory disorders of orbit
0.002 0.986 0.012
H04.8 Other disorders of lachrymal system
0.000 0.987 0.013
H05.2 Exophthalmic conditions
0.002 0.987 0.011
H05.9 Disorder of orbit, unspecified
0.002 0.987 0.011
H04.3 Acute and unspecified inflammation of lachrymal passages
0.000 0.988 0.012
H06.2 Dysthyroid exophthalmos
0.003 0.988 0.010
N31.9 Neuromuscular dysfunction of bladder, unspecified
0.000 0.989 0.011
H04.6 Other changes in lachrymal passages
0.001 0.989 0.011
I35.2 Aortic (valve) stenosis with insufficiency
0.000 0.989 0.011
H33.5 Other retinal detachments
0.000 0.989 0.011
H04.4 Chronic inflammation of lachrymal passages
0.001 0.989 0.010
H05.0 Acute inflammation of orbit
0.002 0.990 0.008
H04.1 Other disorders of lachrymal gland
0.000 0.993 0.007
H02.4 Ptosis of eyelid
0.007 0.993 0.000
H01.0 Blepharitis
0.002 0.993 0.005
H36.0 Diabetic retinopathy
0.000 0.993 0.007
T85.7 Infection and inflammatory reaction due to other internal prosthetic devices, implants and grafts
0.007 0.993 0.000
Y84.2 Radiological procedure and radiotherapy
0.006 0.994 0.000
H33.0 Retinal detachment with retinal break
0.000 0.995 0.005
I35 Nonrheumatic aortic valve disorders
0.000 0.995 0.005
T81.3 Disruption of operation wound, not elsewhere classified
0.000 0.995 0.005
M35.0 Sicca syndrome [Sjogren]
0.000 0.995 0.005
M25.76 Osteophyte (Lower leg)
0.000 0.995 0.005
I35.9 Aortic valve disorder, unspecified
0.000 0.995 0.005
D86.9 Sarcoidosis, unspecified
0.000 0.995 0.005
N31 Neuromuscular dysfunction of bladder, not elsewhere classified
0.000 0.995 0.005
I35.1 Aortic (valve) insufficiency
0.000 0.996 0.004
N31.2 Flaccid neuropathic bladder, not elsewhere classified
0.000 0.996 0.004
J34.3 Hypertrophy of nasal turbinates
0.004 0.996 0.000
D86 Sarcoidosis
0.000 0.996 0.004
M35.3 Polymyalgia rheumatica
0.000 0.996 0.004
H02.9 Disorder of eyelid, unspecified
0.004 0.996 0.000
I35.8 Other aortic valve disorders
0.000 0.996 0.004
C50.4 Upper-outer quadrant of breast
0.000 0.996 0.004
W19.4 Street and highway
0.000 0.996 0.004
M35 Other systemic involvement of connective tissue
0.000 0.996 0.004
H02 Other disorders of eyelid
0.004 0.996 0.000
Q66.8 Other congenital deformities of feet
0.000 0.996 0.004
D86.3 Sarcoidosis of skin
0.000 0.996 0.004
D86.1 Sarcoidosis of lymph nodes
0.000 0.996 0.004
H04.5 Stenosis and insufficiency of lachrymal passages
0.000 0.996 0.004
H00.1 Chalazion
0.003 0.996 0.001
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes
0.000 0.996 0.003
M35.2 Behcet's disease
0.000 0.996 0.004
N31.1 Reflex neuropathic bladder, not elsewhere classified
0.000 0.996 0.003
N31.0 Uninhibited neuropathic bladder, not elsewhere classified
0.000 0.996 0.003
D86.0 Sarcoidosis of lung
0.000 0.996 0.004
M35.8 Other specified systemic involvement of connective tissue
0.000 0.996 0.003
D80-D89 Certain disorders involving the immune mechanism
0.000 0.997 0.003
H33.3 Retinal breaks without detachment
0.000 0.997 0.003
D80 Immunodeficiency with predominantly antibody defects
0.000 0.997 0.003
D80.2 Selective deficiency of immunoglobulin A [IgA]
0.000 0.997 0.003
D83 Common variable immunodeficiency
0.000 0.997 0.003
H02.5 Other disorders affecting eyelid function
0.003 0.997 0.000
M35.9 Systemic involvement of connective tissue, unspecified
0.000 0.997 0.003
M35.6 Relapsing panniculitis [Weber-Christian]
0.000 0.997 0.003
M35.5 Multifocal fibrosclerosis
0.000 0.997 0.003
H02.2 Lagophthalmos
0.003 0.997 0.000
D86.8 Sarcoidosis of other and combined sites
0.000 0.997 0.003
D83.9 Common variable immunodeficiency, unspecified
0.000 0.997 0.003
N30.9 Cystitis, unspecified
0.003 0.997 0.000
M35.4 Diffuse (eosinophilic) fasciitis
0.000 0.997 0.003
D89 Other disorders involving the immune mechanism, not elsewhere classified
0.000 0.997 0.003
H02.7 Other degenerative disorders of eyelid and periocular area
0.003 0.997 0.000
N84.1 Polyp of cervix uteri
0.003 0.997 0.000
D80.1 Nonfamilial hypogammaglobulinaemia
0.000 0.997 0.003
D89.2 Hypergammaglobulinaemia, unspecified
0.000 0.997 0.003
H35 Other retinal disorders
0.000 0.997 0.003
Q66 Congenital deformities of feet
0.000 0.997 0.003
Q66.2 Metatarsus varus
0.000 0.997 0.003
D80.3 Selective deficiency of immunoglobulin G [IgG] subclasses
0.000 0.997 0.003
D82 Immunodeficiency associated with other major defects
0.000 0.997 0.003
D80.6 Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinaemia
0.000 0.997 0.003
Q21.1 Atrial septal defect
0.003 0.997 0.000
D81 Combined immunodeficiencies
0.000 0.997 0.003
M35.1 Other overlap syndromes
0.000 0.997 0.003
D80.7 Transient hypogammaglobulinaemia of infancy
0.000 0.997 0.003
D80.5 Immunodeficiency with increased immunoglobulin M [IgM]
0.000 0.997 0.003
D80.0 Hereditary hypogammaglobulinaemia
0.000 0.997 0.003
M75 Shoulder lesions
0.003 0.997 0.000
D80.8 Other immunodeficiencies with predominantly antibody defects
0.000 0.997 0.003
M35.7 Hypermobility syndrome
0.000 0.997 0.002
D80.4 Selective deficiency of immunoglobulin M [IgM]
0.000 0.997 0.002
D83.8 Other common variable immunodeficiencies
0.000 0.997 0.002
D83.2 Common variable immunodeficiency with autoantibodies to B- or T-cells
0.000 0.997 0.002
D83.1 Common variable immunodeficiency with predominant immunoregulatory T-cell disorders
0.000 0.997 0.002
D83.0 Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
0.000 0.997 0.002
H02.8 Other specified disorders of eyelid
0.003 0.997 0.000
M35.99 Systemic involvement of connective tissue, unspecified, Site unspecified
0.000 0.997 0.002
H02.3 Blepharochalasis
0.003 0.997 0.000
D89.9 Disorder involving the immune mechanism, unspecified
0.000 0.997 0.002
D84 Other immunodeficiencies
0.000 0.997 0.002
C78.2 Secondary malignant neoplasm of pleura
0.003 0.997 0.000
D82.3 Immunodeficiency following hereditary defective response to Epstein-Barr virus
0.000 0.998 0.002
D89.3 Immune reconstitution syndrome
0.000 0.998 0.002
H02.1 Ectropion of eyelid
0.002 0.998 0.000
Q66.6 Other congenital valgus deformities of feet
0.000 0.998 0.002
D89.0 Polyclonal hypergammaglobulinaemia
0.000 0.998 0.002
M75.2 Bicipital tendinitis
0.002 0.998 0.000
Q66.7 Pes cavus
0.000 0.998 0.002
D80.9 Immunodeficiency with predominantly antibody defects, unspecified
0.000 0.998 0.002
E61.1 Iron deficiency
0.002 0.998 0.000
H35.1 Retinopathy of prematurity
0.000 0.998 0.002
Q66.5 Congenital pes planus
0.000 0.998 0.002
Q66.4 Talipes calcaneovalgus
0.000 0.998 0.002
Q66.1 Talipes calcaneovarus
0.000 0.998 0.002
D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified
0.000 0.998 0.002
H35.9 Retinal disorder, unspecified
0.000 0.998 0.002
Q66.0 Talipes equinovarus
0.000 0.998 0.002
D82.9 Immunodeficiency associated with major defect, unspecified
0.000 0.998 0.002
D82.8 Immunodeficiency associated with other specified major defects
0.000 0.998 0.002
D82.4 Hyperimmunoglobulin E [IgE] syndrome
0.000 0.998 0.002
D82.2 Immunodeficiency with short-limbed stature
0.000 0.998 0.002
D82.0 Wiskott-Aldrich syndrome
0.000 0.998 0.002
D89.1 Cryoglobulinaemia
0.000 0.998 0.002
D81.9 Combined immunodeficiency, unspecified
0.000 0.998 0.002
D81.8 Other combined immunodeficiencies
0.000 0.998 0.002
D81.7 Major histocompatibility complex class II deficiency
0.000 0.998 0.002
D81.6 Major histocompatibility complex class I deficiency
0.000 0.998 0.002
D81.5 Purine nucleoside phosphorylase [PNP] deficiency
0.000 0.998 0.002
D81.4 Nezelof's syndrome
0.000 0.998 0.002
D81.3 Adenosine deaminase [ADA] deficiency
0.000 0.998 0.002
D81.2 Severe combined immunodeficiency [SCID] with low or normal B-cell numbers
0.000 0.998 0.002
D81.1 Severe combined immunodeficiency [SCID] with low T- and B-cell numbers
0.000 0.998 0.002
D81.0 Severe combined immunodeficiency [SCID] with reticular dysgenesis
0.000 0.998 0.002
Q66.3 Other congenital varus deformities of feet
0.000 0.998 0.002
Z96.1 Presence of intraocular lens
0.000 0.998 0.002
M75.8 Other shoulder lesions
0.002 0.998 0.000
D50.8 Other iron deficiency anaemias
0.000 0.998 0.002
D82.1 Di George's syndrome
0.000 0.998 0.002
H02.6 Xanthelasma of eyelid
0.002 0.998 0.000
S80.9 Superficial injury of lower leg, unspecified
0.000 0.998 0.002
Q66.9 Congenital deformity of feet, unspecified
0.000 0.998 0.002
J30.1 Allergic rhinitis due to pollen
0.002 0.998 0.000
M34.9 Systemic sclerosis, unspecified
0.000 0.998 0.002
D84.0 Lymphocyte function antigen-1 [LFA-1] defect
0.000 0.998 0.002
Z34.8 Supervision of other normal pregnancy
0.000 0.998 0.002
M75.0 Adhesive capsulitis of shoulder
0.002 0.998 0.000
D84.1 Defects in the complement system
0.000 0.998 0.002
D84.8 Other specified immunodeficiencies
0.000 0.998 0.002
H35.7 Separation of retinal layers
0.000 0.998 0.002
H35.6 Retinal haemorrhage
0.000 0.998 0.002
M75.1 Rotator cuff syndrome
0.002 0.998 0.000
S22.20 Fracture of sternum (closed)
0.000 0.998 0.002
D84.9 Immunodeficiency, unspecified
0.000 0.998 0.002
M48.02 Spinal stenosis (Cervical region)
0.002 0.998 0.000
H35.4 Peripheral retinal degeneration
0.000 0.998 0.002
M80.98 Unspecified osteoporosis with pathological fracture (Other)
0.000 0.998 0.002
I35.0 Aortic (valve) stenosis
0.000 0.998 0.002
Y40.0 Penicillins
0.002 0.998 0.000
M75.81 Other shoulder lesions, right shoulder
0.002 0.998 0.000
Z83.5 Family history of eye and ear disorders
0.000 0.998 0.002
J34.0 Abscess, furuncle and carbuncle of nose
0.002 0.998 0.000
N31.8 Other neuromuscular dysfunction of bladder
0.000 0.998 0.002
H35.2 Other proliferative retinopathy
0.000 0.998 0.001
S80.8 Other superficial injuries of lower leg
0.000 0.998 0.002
N60.3 Fibrosclerosis of breast
0.002 0.998 0.000
R82.9 Other and unspecified abnormal finding in urine
0.002 0.998 0.000
H35.5 Hereditary retinal dystrophy
0.000 0.998 0.001
S02.80 Fractures of other skull and facial bones (closed)
0.000 0.998 0.002
M25.59 Pain in joint (Site unspecified)
0.000 0.998 0.002
K11.5 Sialolithiasis
0.000 0.998 0.002
L05.9 Pilonidal cyst without abscess
0.002 0.998 0.000
S80.0 Contusion of knee
0.000 0.998 0.002
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.998 0.002
M45.X2 Ankylosing spondylitis (Cervical region)
0.000 0.998 0.002
M75.9 Shoulder lesion, unspecified
0.001 0.998 0.000
M54.59 Low back pain (Site unspecified)
0.000 0.998 0.002
I82.8 Embolism and thrombosis of other specified veins
0.000 0.998 0.002
D68.0 Von Willebrand's disease
0.002 0.998 0.000
S80 Superficial injury of lower leg
0.000 0.998 0.002
M75.5 Bursitis of shoulder
0.002 0.998 0.000
T43.3 Phenothiazine antipsychotics and neuroleptics
0.000 0.998 0.002
A40.3 Septicaemia due to Streptococcus pneumoniae
0.001 0.998 0.000
H02.0 Entropion and trichiasis of eyelid
0.001 0.998 0.000
K86.3 Pseudocyst of pancreas
0.000 0.998 0.002
A40.8 Other streptococcal septicaemia
0.001 0.998 0.000
E53.8 Deficiency of other specified B group vitamins
0.002 0.998 0.000
F00.9 Dementia in Alzheimer's disease, unspecified
0.000 0.998 0.001
M45.X9 Ankylosing spondylitis (Site unspecified)
0.000 0.998 0.001
M45.X6 Ankylosing spondylitis (Lumbar region)
0.000 0.998 0.001
J67.9 Hypersensitivity pneumonitis due to unspecified organic dust
0.001 0.998 0.000
N18.4 Chronic kidney disease, stage 4
0.001 0.999 0.000
A40.1 Septicaemia due to streptococcus, group B
0.001 0.999 0.000
E61 Deficiency of other nutrient elements
0.001 0.999 0.000
A40 Streptococcal septicaemia
0.001 0.999 0.000
A40.2 Septicaemia due to streptococcus, group D
0.001 0.999 0.000
H60.9 Otitis externa, unspecified
0.001 0.999 0.000
R16.2 Hepatomegaly with splenomegaly, not elsewhere classified
0.001 0.999 0.000
M45 Ankylosing spondylitis
0.000 0.999 0.001
A40.9 Streptococcal septicaemia, unspecified
0.001 0.999 0.000
Q67.5 Congenital deformity of spine
0.000 0.999 0.001
S64.0 Injury of ulnar nerve at wrist and hand level
0.001 0.999 0.000
T43.5 Other and unspecified antipsychotics and neuroleptics
0.000 0.999 0.001
G80.9 Infantile cerebral palsy, unspecified
0.001 0.999 0.000
N84.2 Polyp of vagina
0.001 0.999 0.000
T43.0 Tricyclic and tetracyclic antidepressants
0.000 0.999 0.001
H60.8 Other otitis externa
0.001 0.999 0.000
K56.5 Intestinal adhesions [bands] with obstruction
0.001 0.999 0.000
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.000 0.999 0.001
S80.1 Contusion of other and unspecified parts of lower leg
0.000 0.999 0.001
G63.2 Diabetic polyneuropathy
0.001 0.999 0.000
K62.8 Other specified diseases of anus and rectum
0.001 0.999 0.000
S64.1 Injury of median nerve at wrist and hand level
0.001 0.999 0.000
E61.9 Deficiency of nutrient element, unspecified
0.001 0.999 0.000
E61.8 Deficiency of other specified nutrient elements
0.001 0.999 0.000
E61.7 Deficiency of multiple nutrient elements
0.001 0.999 0.000
E61.6 Vanadium deficiency
0.001 0.999 0.000
E61.5 Molybdenum deficiency
0.001 0.999 0.000
E61.4 Chromium deficiency
0.001 0.999 0.000
E61.3 Manganese deficiency
0.001 0.999 0.000
E61.0 Copper deficiency
0.001 0.999 0.000
M34.1 CR(E)ST syndrome
0.000 0.999 0.001
M75.3 Calcific tendinitis of shoulder
0.001 0.999 0.000
N95.3 States associated with artificial menopause
0.000 0.999 0.001
V89.2 Person injured in unspecified motor-vehicle accident, traffic
0.000 0.999 0.001
S62.60 Fracture of other finger (closed)
0.001 0.999 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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