TreeWAS – Variant ID: rs17616316

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
S82 Fracture of lower leg, including ankle	0.000	0.987	0.013
S82.30 Fracture of lower end of tibia (closed)	0.000	0.987	0.013
S82.3 Fracture of lower end of tibia	0.000	0.988	0.012
Q20-Q28 Congenital malformations of the circulatory system	0.012	0.988	0.000
S82.4 Fracture of fibula alone	0.000	0.988	0.012
Q24 Other congenital malformations of heart	0.012	0.988	0.000
S82.8 Fractures of other parts of lower leg	0.000	0.988	0.012
S82.40 Fracture of fibula alone (closed)	0.000	0.988	0.012
S82.2 Fracture of shaft of tibia	0.000	0.989	0.011
Q21 Congenital malformations of cardiac septa	0.011	0.989	0.000
Q28 Other congenital malformations of circulatory system	0.011	0.989	0.000
S82.6 Fracture of lateral malleolus	0.000	0.989	0.011
S82.80 Fractures of other parts of lower leg (closed)	0.000	0.989	0.011
S82.5 Fracture of medial malleolus	0.000	0.989	0.011
Q23 Congenital malformations of aortic and mitral valves	0.010	0.989	0.000
S82.20 Fracture of shaft of tibia (closed)	0.000	0.990	0.010
Q27 Other congenital malformations of peripheral vascular system	0.010	0.990	0.000
Q21.1 Atrial septal defect	0.010	0.990	0.000
Q28.2 Arteriovenous malformation of cerebral vessels	0.010	0.990	0.000
Q24.0 Dextrocardia	0.010	0.990	0.000
Q25 Congenital malformations of great arteries	0.010	0.990	0.000
Q24.5 Malformation of coronary vessels	0.010	0.990	0.000
S82.0 Fracture of patella	0.000	0.990	0.010
Q24.8 Other specified congenital malformations of heart	0.010	0.990	0.000
S82.9 Fracture of lower leg, part unspecified	0.000	0.990	0.010
S82.7 Multiple fractures of lower leg	0.000	0.990	0.010
S82.60 Fracture of lateral malleolus (closed)	0.000	0.991	0.009
Q23.1 Congenital insufficiency of aortic valve	0.009	0.991	0.000
Q26 Congenital malformations of great veins	0.009	0.991	0.000
Q22 Congenital malformations of pulmonary and tricuspid valves	0.009	0.991	0.000
Q20 Congenital malformations of cardiac chambers and connexions	0.009	0.991	0.000
S82.81 Fractures of other parts of lower leg (open)	0.000	0.991	0.009
S82.1 Fracture of upper end of tibia	0.000	0.991	0.009
S82.41 Fracture of fibula alone (open)	0.000	0.991	0.009
Q24.9 Congenital malformation of the heart, unspecified	0.009	0.991	0.000
S82.50 Fracture of medial malleolus (closed)	0.000	0.991	0.009
Q24.6 Congenital heart block	0.009	0.991	0.000
Q24.4 Congenital subaortic stenosis	0.009	0.991	0.000
Q24.3 Pulmonary infundibular stenosis	0.009	0.991	0.000
Q24.2 Cor triatriatum	0.009	0.991	0.000
Q24.1 Levocardia	0.009	0.991	0.000
Q27.8 Other specified congenital malformations of peripheral vascular system	0.009	0.991	0.000
S82.86 Maisonneuve's fracture	0.000	0.991	0.009
Q21.0 Ventricular septal defect	0.009	0.991	0.000
Q25.1 Coarctation of aorta	0.008	0.992	0.000
Q21.9 Congenital malformation of cardiac septum, unspecified	0.008	0.992	0.000
Q21.8 Other congenital malformations of cardiac septa	0.008	0.992	0.000
Q21.4 Aortopulmonary septal defect	0.008	0.992	0.000
Q21.3 Tetralogy of Fallot	0.008	0.992	0.000
Q21.2 Atrioventricular septal defect	0.008	0.992	0.000
Q28.9 Congenital malformation of circulatory system, unspecified	0.008	0.992	0.000
Q28.8 Other specified congenital malformations of circulatory system	0.008	0.992	0.000
Q28.3 Other malformations of cerebral vessels	0.008	0.992	0.000
Q28.1 Other malformations of precerebral vessels	0.008	0.992	0.000
Q28.0 Arteriovenous malformation of precerebral vessels	0.008	0.992	0.000
S82.61 Fracture of lateral malleolus (open)	0.000	0.992	0.008
S82.21 Fracture of shaft of tibia (open)	0.000	0.992	0.008
S82.31 Fracture of lower end of tibia (open)	0.000	0.992	0.008
S82.51 Fracture of medial malleolus (open)	0.000	0.992	0.008
Q23.9 Congenital malformation of aortic and mitral valves, unspecified	0.008	0.992	0.000
Q23.8 Other congenital malformations of aortic and mitral valves	0.008	0.992	0.000
Q23.4 Hypoplastic left heart syndrome	0.008	0.992	0.000
Q23.3 Congenital mitral insufficiency	0.008	0.992	0.000
Q23.2 Congenital mitral stenosis	0.008	0.992	0.000
Q23.0 Congenital stenosis of aortic valve	0.008	0.992	0.000
Q27.3 Peripheral arteriovenous malformation	0.008	0.992	0.000
Q27.9 Congenital malformation of peripheral vascular system, unspecified	0.007	0.992	0.000
Q27.4 Congenital phlebectasia	0.007	0.992	0.000
Q27.2 Other congenital malformations of renal artery	0.007	0.992	0.000
Q27.1 Congenital renal artery stenosis	0.007	0.992	0.000
Q27.0 Congenital absence and hypoplasia of umbilical artery	0.007	0.992	0.000
Q25.9 Congenital malformation of great arteries, unspecified	0.007	0.992	0.000
Q25.8 Other congenital malformations of great arteries	0.007	0.992	0.000
Q25.7 Other congenital malformations of pulmonary artery	0.007	0.992	0.000
Q25.6 Stenosis of pulmonary artery	0.007	0.992	0.000
Q25.5 Atresia of pulmonary artery	0.007	0.992	0.000
Q25.4 Other congenital malformations of aorta	0.007	0.992	0.000
Q25.3 Stenosis of aorta	0.007	0.992	0.000
Q25.2 Atresia of aorta	0.007	0.992	0.000
Q25.0 Patent ductus arteriosus	0.007	0.992	0.000
S82.00 Fracture of patella (closed)	0.000	0.993	0.007
S82.01 Fracture of patella (open)	0.000	0.993	0.007
S82.71 Multiple fractures of lower leg (open)	0.000	0.993	0.007
S82.70 Multiple fractures of lower leg (closed)	0.000	0.993	0.007
S82.91 Fracture of lower leg, part unspecified (open)	0.000	0.993	0.007
S82.90 Fracture of lower leg, part unspecified (closed)	0.000	0.993	0.007
Q20.9 Congenital malformation of cardiac chambers and connexions, unspecified	0.007	0.993	0.000
Q20.8 Other congenital malformations of cardiac chambers and connexions	0.007	0.993	0.000
Q20.6 Isomerism of atrial appendages	0.007	0.993	0.000
Q20.5 Discordant atrioventricular connexion	0.007	0.993	0.000
Q20.4 Double inlet ventricle	0.007	0.993	0.000
Q20.3 Discordant ventriculoarterial connexion	0.007	0.993	0.000
Q20.2 Double outlet left ventricle	0.007	0.993	0.000
Q20.1 Double outlet right ventricle	0.007	0.993	0.000
Q20.0 Common arterial trunk	0.007	0.993	0.000
Q22.9 Congenital malformation of tricuspid valve, unspecified	0.007	0.993	0.000
Q22.8 Other congenital malformations of tricuspid valve	0.007	0.993	0.000
Q22.6 Hypoplastic right heart syndrome	0.007	0.993	0.000
Q22.5 Ebstein's anomaly	0.007	0.993	0.000
Q22.4 Congenital tricuspid stenosis	0.007	0.993	0.000
Q22.3 Other congenital malformations of pulmonary valve	0.007	0.993	0.000
Q22.2 Congenital pulmonary valve insufficiency	0.007	0.993	0.000
Q22.1 Congenital pulmonary valve stenosis	0.007	0.993	0.000
Q22.0 Pulmonary valve atresia	0.007	0.993	0.000
Q26.9 Congenital malformation of great vein, unspecified	0.007	0.993	0.000
Q26.8 Other congenital malformations of great veins	0.007	0.993	0.000
Q26.6 Portal vein-hepatic artery fistula	0.007	0.993	0.000
Q26.5 Anomalous portal venous connexion	0.007	0.993	0.000
Q26.4 Anomalous pulmonary venous connexion, unspecified	0.007	0.993	0.000
Q26.3 Partial anomalous pulmonary venous connexion	0.007	0.993	0.000
Q26.2 Total anomalous pulmonary venous connexion	0.007	0.993	0.000
Q26.1 Persistent left superior vena cava	0.007	0.993	0.000
Q26.0 Congenital stenosis of vena cava	0.007	0.993	0.000
S82.11 Fracture of upper end of tibia (open)	0.000	0.993	0.007
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities	0.007	0.993	0.000
Q60-Q64 Congenital malformations of the urinary system	0.006	0.994	0.000
S82.10 Fracture of upper end of tibia (closed)	0.000	0.994	0.006
S80-S89 Injuries to the knee and lower leg	0.000	0.994	0.006
Q63 Other congenital malformations of kidney	0.006	0.994	0.000
T84.0 Mechanical complication of internal joint prosthesis	0.005	0.995	0.000
Q61 Cystic kidney disease	0.005	0.995	0.000
Q50-Q56 Congenital malformations of genital organs	0.005	0.995	0.000
O26.9 Pregnancy-related condition, unspecified	0.005	0.995	0.000
Q10-Q18 Congenital malformations of eye, ear, face and neck	0.005	0.995	0.000
S83 Dislocation, sprain and strain of joints and ligaments of knee	0.000	0.995	0.005
S80 Superficial injury of lower leg	0.000	0.995	0.005
O26 Maternal care for other conditions predominantly related to pregnancy	0.005	0.995	0.000
Q90-Q99 Chromosomal abnormalities, not elsewhere classified	0.005	0.995	0.000
Q35-Q37 Cleft lip and cleft palate	0.005	0.995	0.000
Q30-Q34 Congenital malformations of the respiratory system	0.005	0.995	0.000
Q00-Q07 Congenital malformations of the nervous system	0.005	0.995	0.000
S80.9 Superficial injury of lower leg, unspecified	0.000	0.995	0.005
S83.5 Sprain and strain involving (anterior)(posterior) cruciate ligament of knee	0.000	0.995	0.005
Q61.0 Congenital single renal cyst	0.005	0.995	0.000
I08.1 Disorders of both mitral and tricuspid valves	0.005	0.995	0.000
Q63.0 Accessory kidney	0.005	0.995	0.000
E23.0 Hypopituitarism	0.005	0.995	0.000
Q80-Q89 Other congenital malformations	0.005	0.995	0.000
R04.0 Epistaxis	0.005	0.995	0.000
E23 Hypofunction and other disorders of pituitary gland	0.005	0.995	0.000
Q63.1 Lobulated, fused and horseshoe kidney	0.005	0.995	0.000
Q64 Other congenital malformations of urinary system	0.005	0.995	0.000
Q62 Congenital obstructive defects of renal pelvis and congenital malformations of ureter	0.005	0.995	0.000
I21.1 Acute transmural myocardial infarction of inferior wall	0.000	0.995	0.005
O20-O29 Other maternal disorders predominantly related to pregnancy	0.005	0.995	0.000
Q60 Renal agenesis and other reduction defects of kidney	0.004	0.995	0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system	0.004	0.995	0.000
Q38-Q45 Other congenital malformations of the digestive system	0.004	0.996	0.000
O24.4 Diabetes mellitus arising in pregnancy	0.004	0.996	0.000
O26.8 Other specified pregnancy-related conditions	0.004	0.996	0.000
Q61.2 Polycystic kidney, adult type	0.004	0.996	0.000
O24 Diabetes mellitus in pregnancy	0.004	0.996	0.000
Q50 Congenital malformations of ovaries, Fallopian tubes and broad ligaments	0.004	0.996	0.000
S88 Traumatic amputation of lower leg	0.000	0.996	0.004
S87 Crushing injury of lower leg	0.000	0.996	0.004
S85 Injury of blood vessels at lower leg level	0.000	0.996	0.004
S84 Injury of nerves at lower leg level	0.000	0.996	0.004
S83.6 Sprain and strain of other and unspecified parts of knee	0.000	0.996	0.004
E21 Hyperparathyroidism and other disorders of parathyroid gland	0.004	0.996	0.000
Q63.9 Congenital malformation of kidney, unspecified	0.004	0.996	0.000
Q63.8 Other specified congenital malformations of kidney	0.004	0.996	0.000
Q63.3 Hyperplastic and giant kidney	0.004	0.996	0.000
Q63.2 Ectopic kidney	0.004	0.996	0.000
S80.1 Contusion of other and unspecified parts of lower leg	0.000	0.996	0.004
E20-E35 Disorders of other endocrine glands	0.004	0.996	0.000
Q61.9 Cystic kidney disease, unspecified	0.004	0.996	0.000
Q61.8 Other cystic kidney diseases	0.004	0.996	0.000
Q61.5 Medullary cystic kidney	0.004	0.996	0.000
Q61.4 Renal dysplasia	0.004	0.996	0.000
Q61.1 Polycystic kidney, infantile type	0.004	0.996	0.000
Q12 Congenital lens malformations	0.004	0.996	0.000
E21.0 Primary hyperparathyroidism	0.004	0.996	0.000
Q07 Other congenital malformations of nervous system	0.004	0.996	0.000
S86 Injury of muscle and tendon at lower leg level	0.000	0.996	0.004
J84.1 Other interstitial pulmonary diseases with fibrosis	0.004	0.996	0.000
Z13.9 Special screening examination, unspecified	0.000	0.996	0.004
E23.6 Other disorders of pituitary gland	0.004	0.996	0.000
I08.3 Combined disorders of mitral, aortic and tricuspid valves	0.004	0.996	0.000
E23.2 Diabetes insipidus	0.004	0.996	0.000
Q56 Indeterminate sex and pseudohermaphroditism	0.004	0.996	0.000
Q55 Other congenital malformations of male genital organs	0.004	0.996	0.000
Q53 Undescended testicle	0.004	0.996	0.000
Q52 Other congenital malformations of female genitalia	0.004	0.996	0.000
Q18 Other congenital malformations of face and neck	0.004	0.996	0.000
Q17 Other congenital malformations of ear	0.004	0.996	0.000
Q16 Congenital malformations of ear causing impairment of hearing	0.004	0.996	0.000
Q15 Other congenital malformations of eye	0.004	0.996	0.000
Q14 Congenital malformations of posterior segment of eye	0.004	0.996	0.000
Q13 Congenital malformations of anterior segment of eye	0.004	0.996	0.000
Q11 Anophthalmos, microphthalmos and macrophthalmos	0.004	0.996	0.000
Q10 Congenital malformations of eyelid, lachrymal apparatus and orbit	0.004	0.996	0.000
S83.7 Injury to multiple structures of knee	0.000	0.996	0.004
S83.4 Sprain and strain involving (fibular)(tibial) collateral ligamnent of knee	0.000	0.996	0.004
S83.3 Tear of articular cartilage of knee, current	0.000	0.996	0.004
S83.1 Dislocation of knee	0.000	0.996	0.004
S83.0 Dislocation of patella	0.000	0.996	0.004
O21 Excessive vomiting in pregnancy	0.004	0.996	0.000
Q54 Hypospadias	0.004	0.996	0.000
O26.2 Pregnancy care of habitual aborter	0.004	0.996	0.000
S80.7 Multiple superficial injuries of lower leg	0.000	0.996	0.004
Q51 Congenital malformations of uterus and cervix	0.004	0.996	0.000
O26.7 Subluxation of symphysis (pubis) in pregnancy, childbirth and the puerperium	0.004	0.996	0.000
O26.6 Liver disorders in pregnancy, childbirth and the puerperium	0.004	0.996	0.000
O26.5 Maternal hypotension syndrome	0.004	0.996	0.000
O26.4 Herpes gestationis	0.004	0.996	0.000
O26.3 Retained intra-uterine contraceptive device in pregnancy	0.004	0.996	0.000
O26.1 Low weight gain in pregnancy	0.004	0.996	0.000
O26.0 Excessive weight gain in pregnancy	0.004	0.996	0.000
Q06 Other congenital malformations of spinal cord	0.004	0.996	0.000
Q04 Other congenital malformations of brain	0.004	0.996	0.000
Q03 Congenital hydrocephalus	0.004	0.996	0.000
Q01 Encephalocele	0.004	0.996	0.000
Q00 Anencephaly and similar malformations	0.004	0.996	0.000
Q02 Microcephaly	0.004	0.996	0.000
Q34 Other congenital malformations of respiratory system	0.004	0.996	0.000
Q33 Congenital malformations of lung	0.004	0.996	0.000
Q32 Congenital malformations of trachea and bronchus	0.004	0.996	0.000
Q31 Congenital malformations of larynx	0.004	0.996	0.000
Q30 Congenital malformations of nose	0.004	0.996	0.000
Q37 Cleft palate with cleft lip	0.004	0.996	0.000
Q36 Cleft lip	0.004	0.996	0.000
Q35 Cleft palate	0.004	0.996	0.000
Q99 Other chromosome abnormalities, not elsewhere classified	0.004	0.996	0.000
Q98 Other sex chromosome abnormalities, male phenotype, not elsewhere classified	0.004	0.996	0.000
Q97 Other sex chromosome abnormalities, female phenotype, not elsewhere classified	0.004	0.996	0.000
Q96 Turner's syndrome	0.004	0.996	0.000
Q95 Balanced rearrangements and structural markers, not elsewhere classified	0.004	0.996	0.000
Q93 Monosomies and deletions from the autosomes, not elsewhere classified	0.004	0.996	0.000
Q92 Other trisomies and partial trisomies of the autosomes, not elsewhere classified	0.004	0.996	0.000
Q91 Edwards' syndrome and Patau's syndrome	0.004	0.996	0.000
Q90 Down's syndrome	0.004	0.996	0.000
J98.1 Pulmonary collapse	0.000	0.996	0.004
E27 Other disorders of adrenal gland	0.004	0.996	0.000
Q50.4 Embryonic cyst of Fallopian tube	0.004	0.996	0.000
I08 Multiple valve diseases	0.004	0.996	0.000
E21.1 Secondary hyperparathyroidism, not elsewhere classified	0.004	0.996	0.000
Q61.3 Polycystic kidney, unspecified	0.004	0.996	0.000
O02.0 Blighted ovum and nonhydatidiform mole	0.004	0.996	0.000
O28 Abnormal findings on antenatal screening of mother	0.004	0.996	0.000
Q86 Congenital malformation syndromes due to known exogenous causes, not elsewhere classified	0.004	0.996	0.000
Q84 Other congenital malformations of integument	0.004	0.996	0.000
Q83 Congenital malformations of breast	0.004	0.996	0.000
Q81 Epidermolysis bullosa	0.004	0.996	0.000
Q80 Congenital ichthyosis	0.004	0.996	0.000
E23.7 Disorder of pituitary gland, unspecified	0.004	0.996	0.000
E23.3 Hypothalamic dysfunction, not elsewhere classified	0.004	0.996	0.000
E23.1 Drug-induced hypopituitarism	0.004	0.996	0.000
Q87 Other specified congenital malformation syndromes affecting multiple systems	0.004	0.996	0.000
E05.9 Thyrotoxicosis, unspecified	0.000	0.996	0.004
Q62.8 Other congenital malformations of ureter	0.003	0.996	0.000
Q62.7 Congenital vesico-uretero-renal reflux	0.003	0.996	0.000
Q62.6 Malposition of ureter	0.003	0.996	0.000
Q62.5 Duplication of ureter	0.003	0.996	0.000
Q62.4 Agenesis of ureter	0.003	0.996	0.000
Q62.3 Other obstructive defects of renal pelvis and ureter	0.003	0.996	0.000
Q62.2 Congenital megaloureter	0.003	0.996	0.000
Q62.1 Atresia and stenosis of ureter	0.003	0.996	0.000
Q62.0 Congenital hydronephrosis	0.003	0.996	0.000
Q64.9 Congenital malformation of urinary system, unspecified	0.003	0.996	0.000
Q64.8 Other specified congenital malformations of urinary system	0.003	0.996	0.000
Q64.7 Other congenital malformations of bladder and urethra	0.003	0.996	0.000
Q64.6 Congenital diverticulum of bladder	0.003	0.996	0.000
Q64.5 Congenital absence of bladder and urethra	0.003	0.996	0.000
Q64.4 Malformation of urachus	0.003	0.996	0.000
Q64.3 Other atresia and stenosis of urethra and bladder neck	0.003	0.996	0.000
Q64.2 Congenital posterior urethral valves	0.003	0.996	0.000
Q64.1 Exstrophy of urinary bladder	0.003	0.996	0.000
Q64.0 Epispadias	0.003	0.996	0.000
Q85 Phakomatoses, not elsewhere classified	0.003	0.996	0.000
E22 Hyperfunction of pituitary gland	0.004	0.996	0.000
E78.5 Hyperlipidaemia, unspecified	0.000	0.996	0.004
O02 Other abnormal products of conception	0.004	0.996	0.000
Q89 Other congenital malformations, not elsewhere classified	0.003	0.996	0.000
Q82 Other congenital malformations of skin	0.003	0.996	0.000
S89 Other and unspecified injuries of lower leg	0.000	0.996	0.003
O21.0 Mild hyperemesis gravidarum	0.003	0.996	0.000
O02.1 Missed abortion	0.004	0.996	0.000
O41.0 Oligohydramnios	0.003	0.996	0.000
Q07.0 Arnold-Chiari syndrome	0.003	0.996	0.000
O29 Complications of anaesthesia during pregnancy	0.003	0.996	0.000
O22 Venous complications in pregnancy	0.003	0.996	0.000
O25 Malnutrition in pregnancy	0.003	0.996	0.000
Q60.6 Potter's syndrome	0.003	0.996	0.000
Q60.5 Renal hypoplasia, unspecified	0.003	0.996	0.000
Q60.4 Renal hypoplasia, bilateral	0.003	0.996	0.000
Q60.3 Renal hypoplasia, unilateral	0.003	0.996	0.000
Q60.2 Renal agenesis, unspecified	0.003	0.996	0.000
Q60.1 Renal agenesis, bilateral	0.003	0.996	0.000
Q05 Spina bifida	0.003	0.996	0.000
Q44 Congenital malformations of gallbladder, bile ducts and liver	0.003	0.996	0.000
Q78 Other osteochondrodysplasias	0.003	0.996	0.000
Q77 Osteochondrodysplasia with defects of growth of tubular bones and spine	0.003	0.996	0.000
Q75 Other congenital malformations of skull and face bones	0.003	0.996	0.000
Q74 Other congenital malformations of limb(s)	0.003	0.996	0.000
Q73 Reduction defects of unspecified limb	0.003	0.996	0.000
Q72 Reduction defects of lower limb	0.003	0.996	0.000
Q71 Reduction defects of upper limb	0.003	0.996	0.000
Q70 Syndactyly	0.003	0.996	0.000
Q69 Polydactyly	0.003	0.996	0.000
Q68 Other congenital musculoskeletal deformities	0.003	0.996	0.000
Q67 Congenital musculoskeletal deformities of head, face, spine and chest	0.003	0.996	0.000
Q65 Congenital deformities of hip	0.003	0.996	0.000
E22.1 Hyperprolactinaemia	0.003	0.997	0.000
Q45 Other congenital malformations of digestive system	0.003	0.997	0.000
Q42 Congenital absence, atresia and stenosis of large intestine	0.003	0.997	0.000
Q41 Congenital absence, atresia and stenosis of small intestine	0.003	0.997	0.000
Q40 Other congenital malformations of upper alimentary tract	0.003	0.997	0.000
Q39 Congenital malformations of oesophagus	0.003	0.997	0.000
E21.3 Hyperparathyroidism, unspecified	0.003	0.997	0.000
E26 Hyperaldosteronism	0.003	0.997	0.000
O23 Infections of genito-urinary tract in pregnancy	0.003	0.997	0.000
Q79 Congenital malformations of musculoskeletal system, not elsewhere classified	0.003	0.997	0.000
Q76 Congenital malformations of spine and bony thorax	0.003	0.997	0.000
D68.2 Hereditary deficiency of other clotting factors	0.000	0.997	0.003
O24.9 Diabetes mellitus in pregnancy, unspecified	0.003	0.997	0.000
O24.3 Pre-existing diabetes mellitus, unspecified	0.003	0.997	0.000
O24.2 Pre-existing malnutrition-related diabetes mellitus	0.003	0.997	0.000
O24.1 Pre-existing diabetes mellitus, noninsulin-dependent	0.003	0.997	0.000
Q50.6 Other congenital malformatons of Fallopian tube and broad ligament	0.003	0.997	0.000
Q50.5 Embryonic cyst of broad ligament	0.003	0.997	0.000
Q50.3 Other congenital malformations of ovary	0.003	0.997	0.000
Q50.2 Congenital torsion of ovary	0.003	0.997	0.000
Q50.1 Developmental ovarian cyst	0.003	0.997	0.000
Q50.0 Congenital absence of ovary	0.003	0.997	0.000
Q12.0 Congenital cataract	0.003	0.997	0.000
S80.8 Other superficial injuries of lower leg	0.000	0.997	0.003
S84.9 Injury of unspecified nerve at lower leg level	0.000	0.997	0.003
S84.8 Injury of other nerves at lower leg level	0.000	0.997	0.003
S84.7 Injury of multiple nerves at lower leg level	0.000	0.997	0.003
S84.2 Injury of cutaneous sensory nerve at lower leg level	0.000	0.997	0.003
S84.1 Injury of peroneal nerve at lower leg level	0.000	0.997	0.003
S84.0 Injury of tibial nerve at lower leg level	0.000	0.997	0.003
S85.9 Injury of unspecified blood vessel at lower leg level	0.000	0.997	0.003
S85.8 Injury of other blood vessels at lower leg level	0.000	0.997	0.003
S85.7 Injury of multiple blood vessels at lower leg level	0.000	0.997	0.003
S85.5 Injury of popliteal vein	0.000	0.997	0.003
S85.4 Injury of lesser saphenous vein at lower leg level	0.000	0.997	0.003
S85.3 Injury of greater saphenous vein at lower leg level	0.000	0.997	0.003
S85.2 Injury of peroneal artery	0.000	0.997	0.003
S85.1 Injury of (anterior)(posterior) tibial artery	0.000	0.997	0.003
S85.0 Injury of popliteal artery	0.000	0.997	0.003
S87.8 Crushing injury of other and unspecified parts of lower leg	0.000	0.997	0.003
S87.0 Crushing injury of knee	0.000	0.997	0.003
S88.9 Traumatic amputation of lower leg, level unspecified	0.000	0.997	0.003
S88.1 Traumatic amputation at level between knee and ankle	0.000	0.997	0.003
S88.0 Traumatic amputation at knee level	0.000	0.997	0.003
E34 Other endocrine disorders	0.003	0.997	0.000
E27.1 Primary adrenocortical insufficiency	0.003	0.997	0.000
E21.5 Disorder of parathyroid gland, unspecified	0.003	0.997	0.000
E21.4 Other specified disorders of parathyroid gland	0.003	0.997	0.000
E21.2 Other hyperparathyroidism	0.003	0.997	0.000
O24.0 Pre-existing diabetes mellitus, insulin-dependent	0.003	0.997	0.000
E24 Cushing's syndrome	0.003	0.997	0.000
J84.9 Interstitial pulmonary disease, unspecified	0.003	0.997	0.000
N85.8 Other specified noninflammatory disorders of uterus	0.003	0.997	0.000
E35 Disorders of endocrine glands in diseases classified elsewhere	0.003	0.997	0.000
E32 Diseases of thymus	0.003	0.997	0.000
E31 Polyglandular dysfunction	0.003	0.997	0.000
E30 Disorders of puberty, not elsewhere classified	0.003	0.997	0.000
E25 Adrenogenital disorders	0.003	0.997	0.000
E20 Hypoparathyroidism	0.003	0.997	0.000
O20 Haemorrhage in early pregnancy	0.003	0.997	0.000
S81 Open wound of lower leg	0.000	0.997	0.003
E29 Testicular dysfunction	0.003	0.997	0.000
Q12.9 Congenital lens malformation, unspecified	0.003	0.997	0.000
Q12.8 Other congenital lens malformations	0.003	0.997	0.000
Q12.4 Spherophakia	0.003	0.997	0.000
Q12.3 Congenital aphakia	0.003	0.997	0.000
Q12.2 Coloboma of lens	0.003	0.997	0.000
Q12.1 Congenital displaced lens	0.003	0.997	0.000
Q60.0 Renal agenesis, unilateral	0.003	0.997	0.000
J84 Other interstitial pulmonary diseases	0.003	0.997	0.000
E27.2 Addisonian crisis	0.003	0.997	0.000
I08.2 Disorders of both aortic and tricuspid valves	0.003	0.997	0.000
Q07.9 Congenital malformation of nervous system, unspecified	0.003	0.997	0.000
Q07.8 Other specified congenital malformations of nervous system	0.003	0.997	0.000
S86.0 Injury of Achilles tendon	0.000	0.997	0.003
S86.7 Injury of multiple muscles and tendons at lower leg level	0.000	0.997	0.003
S86.3 Injury of muscle(s) and tendon(s) of peroneal muscle group at lower leg level	0.000	0.997	0.003
S86.2 Injury of muscle(s) and tendon(s) of anterior muscle group at lower leg level	0.000	0.997	0.003
S86.1 Injury of other muscle(s) and tendon(s) of posterior muscle group at lower leg level	0.000	0.997	0.003
Q43 Other congenital malformations of intestine	0.003	0.997	0.000
K22.1 Ulcer of oesophagus	0.000	0.997	0.003
S80.0 Contusion of knee	0.000	0.997	0.003
Q51.2 Other doubling of uterus	0.003	0.997	0.000
Q52.9 Congenital malformation of female genitalia, unspecified	0.003	0.997	0.000
Q52.8 Other specified congenital malformations of female genitalia	0.003	0.997	0.000
Q52.7 Other congenital malformations of vulva	0.003	0.997	0.000
Q52.6 Congenital malformation of clitoris	0.003	0.997	0.000
Q52.5 Fusion of labia	0.003	0.997	0.000
Q52.4 Other congenital malformations of vagina	0.003	0.997	0.000
Q52.3 Imperforate hymen	0.003	0.997	0.000
Q52.2 Congenital rectovaginal fistula	0.003	0.997	0.000
Q52.1 Doubling of vagina	0.003	0.997	0.000
Q52.0 Congenital absence of vagina	0.003	0.997	0.000
Q53.9 Undescended testicle, unspecified	0.003	0.997	0.000
Q53.2 Undescended testicle, bilateral	0.003	0.997	0.000
Q53.1 Undescended testicle, unilateral	0.003	0.997	0.000
Q53.0 Ectopic testis	0.003	0.997	0.000
Q55.9 Congenital malformation of male genital organ, unspecified	0.003	0.997	0.000
Q55.8 Other specified congenital malformations of male genital organs	0.003	0.997	0.000
Q55.6 Other congenital malformations of penis	0.003	0.997	0.000
Q55.5 Congenital absence and aplasia of penis	0.003	0.997	0.000
Q55.4 Other congenital malformations of vas deferens, epididymis, seminal vesicles and prostate	0.003	0.997	0.000
Q55.3 Atresia of vas deferens	0.003	0.997	0.000
Q55.2 Other congenital malformations of testis and scrotum	0.003	0.997	0.000
Q55.1 Hypoplasia of testis and scrotum	0.003	0.997	0.000
Q55.0 Absence and aplasia of testis	0.003	0.997	0.000
Q56.4 Indeterminate sex, unspecified	0.003	0.997	0.000
Q56.3 Pseudohermaphroditism, unspecified	0.003	0.997	0.000
Q56.2 Female pseudohermaphroditism, not elsewhere classified	0.003	0.997	0.000
Q56.1 Male pseudohermaphroditism, not elsewhere classified	0.003	0.997	0.000
Q56.0 Hermaphroditism, not elsewhere classified	0.003	0.997	0.000
Q38 Other congenital malformations of tongue, mouth and pharynx	0.003	0.997	0.000
Q10.7 Congenital malformation of orbit	0.003	0.997	0.000
Q10.6 Other congenital malformations of lachrymal apparatus	0.003	0.997	0.000
Q10.5 Congenital stenosis and stricture of lachrymal duct	0.003	0.997	0.000
Q10.4 Absence and agenesis of lachrymal apparatus	0.003	0.997	0.000
Q10.3 Other congenital malformations of eyelid	0.003	0.997	0.000
Q10.2 Congenital entropion	0.003	0.997	0.000
Q10.1 Congenital ectropion	0.003	0.997	0.000
Q10.0 Congenital ptosis	0.003	0.997	0.000
Q11.3 Macrophthalmos	0.003	0.997	0.000
Q11.2 Microphthalmos	0.003	0.997	0.000
Q11.1 Other anophthalmos	0.003	0.997	0.000
Q11.0 Cystic eyeball	0.003	0.997	0.000
Q13.9 Congenital malformation of anterior segment of eye, unspecified	0.003	0.997	0.000
Q13.8 Other congenital malformations of anterior segment of eye	0.003	0.997	0.000
Q13.5 Blue sclera	0.003	0.997	0.000
Q13.4 Other congenital corneal malformations	0.003	0.997	0.000
Q13.3 Congenital corneal opacity	0.003	0.997	0.000
Q13.2 Other congenital malformations of iris	0.003	0.997	0.000
Q13.1 Absence of iris	0.003	0.997	0.000
Q13.0 Coloboma of iris	0.003	0.997	0.000
Q14.9 Congenital malformation of posterior segment of eye, unspecified	0.003	0.997	0.000
Q14.8 Other congenital malformations of posterior segment of eye	0.003	0.997	0.000
Q14.3 Congenital malformation of choroid	0.003	0.997	0.000
Q14.2 Congenital malformation of optic disk	0.003	0.997	0.000
Q14.1 Congenital malformation of retina	0.003	0.997	0.000
Q14.0 Congenital malformation of vitreous humour	0.003	0.997	0.000
Q15.9 Congenital malformation of eye, unspecified	0.003	0.997	0.000
Q15.8 Other specified congenital malformations of eye	0.003	0.997	0.000
Q15.0 Congenital glaucoma	0.003	0.997	0.000
Q16.9 Congenital malformation of ear causing impairment of hearing, unspecified	0.003	0.997	0.000
Q16.5 Congenital malformation of inner ear	0.003	0.997	0.000
Q16.4 Other congenital malformations of middle ear	0.003	0.997	0.000
Q16.3 Congenital malformation of ear ossicles	0.003	0.997	0.000
Q16.2 Absence of eustachian tube	0.003	0.997	0.000
Q16.1 Congenital absence, atresia and stricture of auditory canal (external)	0.003	0.997	0.000
Q16.0 Congenital absence of (ear) auricle	0.003	0.997	0.000
Q17.9 Congenital malformation of ear, unspecified	0.003	0.997	0.000
Q17.8 Other specified congenital malformations of ear	0.003	0.997	0.000
Q17.5 Prominent ear	0.003	0.997	0.000
Q17.4 Misplaced ear	0.003	0.997	0.000
Q17.3 Other misshapen ear	0.003	0.997	0.000
Q17.2 Microtia	0.003	0.997	0.000
Q17.1 Macrotia	0.003	0.997	0.000
Q17.0 Accessory auricle	0.003	0.997	0.000
Q18.9 Congenital malformation of face and neck, unspecified	0.003	0.997	0.000
Q18.8 Other specified congenital malformations of face and neck	0.003	0.997	0.000
Q18.7 Microcheilia	0.003	0.997	0.000
Q18.6 Macrocheilia	0.003	0.997	0.000
Q18.5 Microstomia	0.003	0.997	0.000
Q18.4 Macrostomia	0.003	0.997	0.000
Q18.3 Webbing of neck	0.003	0.997	0.000
Q18.2 Other branchial cleft malformations	0.003	0.997	0.000
Q18.1 Preauricular sinus and cyst	0.003	0.997	0.000
Q18.0 Sinus, fistula and cyst of branchial cleft	0.003	0.997	0.000
Q66 Congenital deformities of feet	0.003	0.997	0.000
S86.9 Injury of unspecified muscle and tendon at lower leg level	0.000	0.997	0.003
O21.9 Vomiting of pregnancy, unspecified	0.003	0.997	0.000
O21.8 Other vomiting complicating pregnancy	0.003	0.997	0.000
O21.2 Late vomiting of pregnancy	0.003	0.997	0.000
O21.1 Hyperemesis gravidarum with metabolic disturbance	0.003	0.997	0.000
O28.1 Abnormal biochemical finding on antenatal screening of mother	0.003	0.997	0.000
S86.8 Injury of other muscles and tendons at lower leg level	0.000	0.997	0.003
Q54.8 Other hypospadias	0.003	0.997	0.000
Q54.4 Congenital chordee	0.003	0.997	0.000
Q54.3 Hypospadias, perineal	0.003	0.997	0.000
Q54.2 Hypospadias, penoscrotal	0.003	0.997	0.000
Q54.1 Hypospadias, penile	0.003	0.997	0.000
Q54.0 Hypospadias, balanic	0.003	0.997	0.000
E27.9 Disorder of adrenal gland, unspecified	0.003	0.997	0.000
Q30.9 Congenital malformation of nose, unspecified	0.003	0.997	0.000
Q30.8 Other congenital malformations of nose	0.003	0.997	0.000
Q30.3 Congenital perforated nasal septum	0.003	0.997	0.000
Q30.2 Fissured, notched and cleft nose	0.003	0.997	0.000
Q30.1 Agenesis and underdevelopment of nose	0.003	0.997	0.000
Q30.0 Choanal atresia	0.003	0.997	0.000
Q31.9 Congenital malformation of larynx, unspecified	0.003	0.997	0.000
Q31.8 Other congenital malformations of larynx	0.003	0.997	0.000
Q31.5 Congenital laryngomalacia	0.003	0.997	0.000
Q31.4 Congenital laryngeal stridor	0.003	0.997	0.000
Q31.3 Laryngocele	0.003	0.997	0.000
Q31.2 Laryngeal hypoplasia	0.003	0.997	0.000
Q31.1 Congenital subglottic stenosis	0.003	0.997	0.000
Q31.0 Web of larynx	0.003	0.997	0.000
Q32.4 Other congenital malformations of bronchus	0.003	0.997	0.000
Q32.3 Congenital stenosis of bronchus	0.003	0.997	0.000
Q32.2 Congenital bronchomalacia	0.003	0.997	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations