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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs17758321
log Bayes Factor = 11.5799
Chromosome 14   position 79,928,225  (GRCh37) Explore rs17758321 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
Chapter XIII Diseases of the musculoskeletal system and connective tissue
1.000 0.000 0.000
# Top node
1.000 0.000 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
1.000 0.000 0.000
M25 Other joint disorders, not elsewhere classified
1.000 0.000 0.000
M20-M25 Other joint disorders
1.000 0.000 0.000
T80-T88 Complications of surgical and medical care, not elsewhere classified
1.000 0.000 0.000
Chapter IX Diseases of the circulatory system
0.998 0.002 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.998 0.002 0.000
Chapter XX External causes of morbidity and mortality
0.998 0.002 0.000
T82 Complications of cardiac and vascular prosthetic devices, implants and grafts
0.998 0.002 0.000
I70-I79 Diseases of arteries, arterioles and capillaries
0.996 0.004 0.000
M25.5 Pain in joint
0.995 0.005 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.987 0.013 0.000
T82.8 Other complications of cardiac and vascular prosthetic devices, implants and grafts
0.983 0.017 0.000
T85 Complications of other internal prosthetic devices, implants and grafts
0.981 0.019 0.000
E20-E35 Disorders of other endocrine glands
0.976 0.024 0.000
E65-E68 Obesity and other hyperalimentation
0.976 0.024 0.000
I77 Other disorders of arteries and arterioles
0.976 0.024 0.000
I74 Arterial embolism and thrombosis
0.963 0.037 0.000
M25.53 Pain in joint (Forearm)
0.963 0.037 0.000
E66 Obesity
0.959 0.041 0.000
I95-I99 Other and unspecified disorders of the circulatory system
0.958 0.042 0.000
Chapter XXI Factors influencing health status and contact with health services
0.952 0.048 0.000
M25.50 Pain in joint (Multiple sites)
0.945 0.055 0.000
T85.8 Other complications of internal prosthetic devices, implants and grafts, not elsewhere classified
0.945 0.055 0.000
Z30-Z39 Persons encountering health services in circumstances related to reproduction
0.942 0.058 0.000
M25.7 Osteophyte
0.941 0.059 0.000
T82.5 Mechanical complication of other cardiac and vascular devices and implants
0.937 0.063 0.000
M05-M14 Inflammatory polyarthropathies
0.934 0.066 0.000
T79-T79 Certain early complications of trauma
0.933 0.067 0.000
M70-M79 Other soft tissue disorders
0.933 0.067 0.000
Y52 Agents primarily affecting the cardiovascular system
0.932 0.068 0.000
Chapter I Certain infectious and parasitic diseases
0.932 0.068 0.000
Z30 Contraceptive management
0.931 0.069 0.000
Z30.2 Sterilisation
0.928 0.072 0.000
E70-E90 Metabolic disorders
0.928 0.072 0.000
Y90-Y98 Supplementary factors related to causes of morbidity and mortality classified elsewhere
0.927 0.072 0.000
M25.54 Pain in joint (Hand)
0.925 0.075 0.000
E87 Other disorders of fluid, electrolyte and acid-base balance
0.922 0.078 0.000
Z70-Z76 Persons encountering health services in other circumstances
0.921 0.079 0.000
I73 Other peripheral vascular diseases
0.917 0.083 0.000
M25.8 Other specified joint disorders
0.916 0.084 0.000
T84 Complications of internal orthopaedic prosthetic devices, implants and grafts
0.910 0.090 0.000
M79 Other soft tissue disorders, not elsewhere classified
0.906 0.094 0.000
I77.1 Stricture of artery
0.906 0.094 0.000
T66-T78 Other and unspecified effects of external causes
0.905 0.095 0.000
M25.4 Effusion of joint
0.903 0.097 0.000
S90-S99 Injuries to the ankle and foot
0.903 0.097 0.000
E66.8 Other obesity
0.896 0.104 0.000
I77.6 Arteritis, unspecified
0.896 0.104 0.000
Z74 Problems related to care-provider dependency
0.895 0.105 0.000
E66.9 Obesity, unspecified
0.892 0.108 0.000
T79 Certain early complications of trauma, not elsewhere classified
0.885 0.115 0.000
M65-M68 Disorders of synovium and tendon
0.885 0.115 0.000
I74.3 Embolism and thrombosis of arteries of the lower extremities
0.884 0.116 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.879 0.121 0.000
I73.9 Peripheral vascular disease, unspecified
0.877 0.123 0.000
T84.1 Mechanical complication of internal fixation device of bones of limb
0.874 0.126 0.000
I30-I52 Other forms of heart disease
0.874 0.126 0.000
Z35 Supervision of high-risk pregnancy
0.873 0.127 0.000
S80-S89 Injuries to the knee and lower leg
0.871 0.129 0.000
E87.1 Hypo-osmolality and hyponatraemia
0.869 0.131 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.867 0.133 0.000
Y42 Hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.866 0.134 0.000
Y95 Nosocomial condition
0.863 0.137 0.000
Z74.0 Reduced mobility
0.863 0.137 0.000
I74.5 Embolism and thrombosis of iliac artery
0.863 0.137 0.000
I50 Heart failure
0.861 0.139 0.000
B95-B98 Bacterial, viral and other infectious agents
0.860 0.140 0.000
M91-M94 Chondropathies
0.858 0.142 0.000
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.858 0.142 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.855 0.145 0.000
T79.3 Post-traumatic wound infection, not elsewhere classified
0.853 0.147 0.000
M15-M19 Arthrosis
0.851 0.149 0.000
M24 Other specific joint derangements
0.850 0.150 0.000
Y45 Analgesics, antipyretics and anti-inflammatory drugs
0.849 0.151 0.000
M05 Seropositive rheumatoid arthritis
0.847 0.153 0.000
M21 Other acquired deformities of limbs
0.845 0.155 0.000
Chapter XII Diseases of the skin and subcutaneous tissue
0.845 0.155 0.000
E23 Hypofunction and other disorders of pituitary gland
0.844 0.156 0.000
M25.58 Pain in joint (Other)
0.840 0.160 0.000
I95 Hypotension
0.840 0.160 0.000
M19 Other arthrosis
0.834 0.166 0.000
M25.46 Effusion of joint (Lower leg)
0.834 0.166 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.833 0.166 0.000
I50.1 Left ventricular failure
0.833 0.167 0.000
V40-V49 Car occupant injured in transport accident
0.831 0.169 0.000
Y40 Systemic antibiotics
0.829 0.171 0.000
M25.3 Other instability of joint
0.829 0.171 0.000
T85.2 Mechanical complication of intraocular lens
0.826 0.174 0.000
V10-V19 Pedal cyclist injured in transport accident
0.825 0.175 0.000
S82 Fracture of lower leg, including ankle
0.822 0.178 0.000
M25.78 Osteophyte (Other)
0.822 0.178 0.000
E87.6 Hypokalaemia
0.822 0.178 0.000
M25.86 Other specified joint disorders (Lower leg)
0.821 0.179 0.000
T82.2 Mechanical complication of coronary artery bypass and valve grafts
0.820 0.180 0.000
I98 Other disorders of circulatory system in diseases classified elsewhere
0.819 0.181 0.000
E28 Ovarian dysfunction
0.818 0.182 0.000
E27 Other disorders of adrenal gland
0.817 0.183 0.000
M06 Other rheumatoid arthritis
0.816 0.184 0.000
T82.7 Infection and inflammatory reaction due to other cardiac and vascular devices, implants and grafts
0.815 0.185 0.000
M19.9 Arthrosis, unspecified
0.813 0.187 0.000
I05-I09 Chronic rheumatic heart diseases
0.813 0.187 0.000
I50.9 Heart failure, unspecified
0.812 0.188 0.000
Z71 Persons encountering health services for other counselling and medical advice, not elsewhere classified
0.811 0.189 0.000
Z34 Supervision of normal pregnancy
0.808 0.192 0.000
Z31 Procreative management
0.804 0.196 0.000
M79.6 Pain in limb
0.803 0.197 0.000
I99 Other and unspecified disorders of circulatory system
0.800 0.200 0.000
Z35.5 Supervision of elderly primigravida
0.800 0.200 0.000
Y52.1 Calcium-channel blockers
0.800 0.200 0.000
Q50-Q56 Congenital malformations of genital organs
0.799 0.201 0.000
M25.56 Pain in joint (Lower leg)
0.798 0.202 0.000
M79.8 Other specified soft tissue disorders
0.798 0.202 0.000
T85.6 Mechanical complication of other specified internal prosthetic devices, implants and grafts
0.797 0.203 0.000
T36-T50 Poisoning by drugs, medicaments and biological substances
0.797 0.203 0.000
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.795 0.205 0.000
T78 Adverse effects, not elsewhere classified
0.795 0.205 0.000
I44 Atrioventricular and left bundle-branch block
0.794 0.206 0.000
M77 Other enthesopathies
0.792 0.208 0.000
M22 Disorders of patella
0.791 0.209 0.000
M25.0 Haemarthrosis
0.790 0.210 0.000
B96 Other bacterial agents as the cause of diseases classified to other chapters
0.790 0.210 0.000
Y52.4 Angiotensin-converting-enzyme inhibitors
0.789 0.211 0.000
M19.90 Arthrosis, unspecified (Multiple sites)
0.789 0.211 0.000
V80-V89 Other land transport accidents
0.789 0.211 0.000
M05.9 Seropositive rheumatoid arthritis, unspecified
0.785 0.215 0.000
I70 Atherosclerosis
0.784 0.216 0.000
V20-V29 Motorcycle rider injured in transport accident
0.783 0.217 0.000
D60-D64 Aplastic and other anaemias
0.782 0.218 0.000
S92 Fracture of foot, except ankle
0.780 0.220 0.000
M79.1 Myalgia
0.777 0.223 0.000
M25.71 Osteophyte (Shoulder region)
0.774 0.226 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.772 0.228 0.000
L80-L99 Other disorders of the skin and subcutaneous tissue
0.772 0.228 0.000
M25.57 Pain in joint (Ankle and foot)
0.772 0.228 0.000
S82.8 Fractures of other parts of lower leg
0.772 0.228 0.000
M65 Synovitis and tenosynovitis
0.771 0.229 0.000
Y52.5 Other antihypertensive drugs, not elsewhere classified
0.771 0.229 0.000
M96 Postprocedural musculoskeletal disorders, not elsewhere classified
0.768 0.232 0.000
T71 Asphyxiation
0.767 0.233 0.000
E87.5 Hyperkalaemia
0.767 0.233 0.000
Y46 Antiepileptics and anti-Parkinsonism drugs
0.767 0.233 0.000
T85.7 Infection and inflammatory reaction due to other internal prosthetic devices, implants and grafts
0.765 0.235 0.000
Y42.7 Androgens and anabolic congeners
0.764 0.236 0.000
X58-X59 Accidental exposure to other and unspecified factors
0.763 0.237 0.000
E87.0 Hyperosmolality and hypernatraemia
0.762 0.238 0.000
T87 Complications peculiar to reattachment and amputation
0.762 0.238 0.000
T82.9 Unspecified complication of cardiac and vascular prosthetic device, implant and graft
0.761 0.239 0.000
T85.0 Mechanical complication of ventricular intracranial (communicating) shunt
0.761 0.239 0.000
M06.9 Rheumatoid arthritis, unspecified
0.761 0.239 0.000
M00-M03 Infectious arthropathies
0.760 0.240 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.759 0.241 0.000
Y52.3 Coronary vasodilators, not elsewhere classified
0.759 0.241 0.000
S50-S59 Injuries to the elbow and forearm
0.758 0.242 0.000
M33 Dermatopolymyositis
0.758 0.242 0.000
M25.72 Osteophyte (Upper arm)
0.757 0.243 0.000
Chapter XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
0.755 0.245 0.000
I33 Acute and subacute endocarditis
0.752 0.248 0.000
Y57 Other and unspecified drugs and medicaments
0.752 0.248 0.000
M86-M90 Other osteopathies
0.751 0.249 0.000
Y54 Agents primarily affecting water-balance and mineral and uric acid metabolism
0.751 0.249 0.000
M35 Other systemic involvement of connective tissue
0.751 0.249 0.000
B98 Other specified infectious agents as the cause of diseases classified to other chapters
0.749 0.251 0.000
X60-X84 Intentional self-harm
0.748 0.251 0.000
Y83-Y84 Surgical and other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
0.747 0.252 0.000
Z55-Z65 Persons with potential health hazards related to socioeconomic and psychosocial circumstances
0.747 0.253 0.000
M21.3 Wrist or foot drop (acquired)
0.747 0.253 0.000
Z71.3 Dietary counselling and surveillance
0.746 0.254 0.000
M45-M49 Spondylopathies
0.746 0.254 0.000
E66.0 Obesity due to excess calories
0.744 0.256 0.000
E50-E64 Other nutritional deficiencies
0.744 0.256 0.000
E21.3 Hyperparathyroidism, unspecified
0.744 0.256 0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use
0.743 0.257 0.000
S10-S19 Injuries to the neck
0.743 0.257 0.000
L00-L08 Infections of the skin and subcutaneous tissue
0.742 0.258 0.000
M10 Gout
0.742 0.258 0.000
I97 Postprocedural disorders of circulatory system, not elsewhere classified
0.742 0.258 0.000
I77.9 Disorder of arteries and arterioles, unspecified
0.742 0.258 0.000
M25.77 Osteophyte (Ankle and foot)
0.741 0.259 0.000
M80-M85 Disorders of bone density and structure
0.738 0.262 0.000
Y00-Y09 Assault
0.738 0.262 0.000
I77.8 Other specified disorders of arteries and arterioles
0.737 0.263 0.000
Z73 Problems related to life-management difficulty
0.737 0.263 0.000
R47-R49 Symptoms and signs involving speech and voice
0.736 0.264 0.000
M93 Other osteochondropathies
0.734 0.265 0.000
M60-M63 Disorders of muscles
0.734 0.266 0.000
M79.60 Pain in limb (Multiple sites)
0.732 0.268 0.000
M24.0 Loose body in joint
0.732 0.268 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.731 0.269 0.000
B99-B99 Other infectious diseases
0.731 0.269 0.000
T93 Sequelae of injuries of lower limb
0.730 0.270 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.729 0.270 0.000
T82.3 Mechanical complication of other vascular grafts
0.729 0.271 0.000
D63 Anaemia in chronic diseases classified elsewhere
0.728 0.272 0.000
E29 Testicular dysfunction
0.727 0.273 0.000
I42 Cardiomyopathy
0.727 0.273 0.000
I95.9 Hypotension, unspecified
0.727 0.273 0.000
M71 Other bursopathies
0.725 0.275 0.000
T85.1 Mechanical complication of implanted electronic stimulator of nervous system
0.725 0.275 0.000
S91 Open wound of ankle and foot
0.724 0.276 0.000
M79.7 Fibromyalgia
0.723 0.277 0.000
E34 Other endocrine disorders
0.722 0.278 0.000
E87.2 Acidosis
0.722 0.278 0.000
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.722 0.278 0.000
Y60-Y69 Misadventures to patients during surgical and medical care
0.722 0.278 0.000
I74.8 Embolism and thrombosis of other arteries
0.722 0.278 0.000
Z30.8 Other contraceptive management
0.722 0.278 0.000
Y91 Evidence of alcohol involvement determined by level of intoxication
0.722 0.278 0.000
E24 Cushing's syndrome
0.721 0.278 0.000
S82.80 Fractures of other parts of lower leg (closed)
0.719 0.281 0.000
E65 Localised adiposity
0.718 0.282 0.000
A50-A64 Infections with a predominantly sexual mode of transmission
0.718 0.282 0.000
Q51 Congenital malformations of uterus and cervix
0.718 0.282 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
T33-T35 Frostbite
0.717 0.283 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.717 0.283 0.000
T00-T07 Injuries involving multiple body regions
0.717 0.283 0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.717 0.283 0.000
M32 Systemic lupus erythematosus
0.717 0.283 0.000
M30 Polyarteritis nodosa and related conditions
0.717 0.283 0.000
M25.9 Joint disorder, unspecified
0.717 0.283 0.000
M25.2 Flail joint
0.717 0.283 0.000
M25.1 Fistula of joint
0.717 0.283 0.000
M25.83 Other specified joint disorders (Forearm)
0.717 0.283 0.000
I00-I02 Acute rheumatic fever
0.715 0.284 0.000
Y35-Y36 Legal intervention and operations of war
0.715 0.285 0.000
Y10-Y34 Event of undetermined intent
0.715 0.285 0.000
X85-X99 Assault
0.715 0.285 0.000
X50-X57 Overexertion, travel and privation
0.715 0.285 0.000
X30-X39 Exposure to forces of nature
0.715 0.285 0.000
X10-X19 Contact with heat and hot substances
0.715 0.285 0.000
X00-X09 Exposure to smoke, fire and flames
0.715 0.285 0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure
0.715 0.285 0.000
W75-W84 Other accidental threats to breathing
0.715 0.285 0.000
W65-W74 Accidental drowning and submersion
0.715 0.285 0.000
V98-V99 Other and unspecified transport accidents
0.715 0.285 0.000
V95-V97 Air and space transport accidents
0.715 0.285 0.000
V90-V94 Water transport accidents
0.715 0.285 0.000
V70-V79 Bus occupant injured in transport accident
0.715 0.285 0.000
V60-V69 Occupant of heavy transport vehicle injured in transport accident
0.715 0.285 0.000
V50-V59 Occupant of pick-up truck or van injured in transport accident
0.715 0.285 0.000
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident
0.715 0.285 0.000
V01-V09 Pedestrian injured in transport accident
0.715 0.285 0.000
T82.6 Infection and inflammatory reaction due to cardiac valve prosthesis
0.715 0.285 0.000
T82.4 Mechanical complication of vascular dialysis catheter
0.715 0.285 0.000
T82.0 Mechanical complication of heart valve prosthesis
0.715 0.285 0.000
T85.9 Unspecified complication of internal prosthetic device, implant and graft
0.714 0.286 0.000
B96.3 Haemophilus influenzae [H. influenzae] as the cause of diseases classified to other chapters
0.713 0.286 0.000
M25.75 Osteophyte (Pelvic region and thigh)
0.712 0.288 0.000
V49 Car occupant injured in other and unspecified transport accidents
0.712 0.288 0.000
T86 Failure and rejection of transplanted organs and tissues
0.711 0.288 0.000
I08 Multiple valve diseases
0.711 0.289 0.000
T92 Sequelae of injuries of upper limb
0.711 0.289 0.000
Y59 Other and unspecified vaccines and biological substances
0.707 0.293 0.000
Y58 Bacterial vaccines
0.707 0.293 0.000
Y55 Agents primarily acting on smooth and skeletal muscles and the respiratory system
0.707 0.293 0.000
Y53 Agents primarily affecting the gastro-intestinal system
0.707 0.293 0.000
Y50 Central nervous system stimulants, not elsewhere classified
0.707 0.293 0.000
Y49 Psychotropic drugs, not elsewhere classified
0.707 0.293 0.000
Y48 Anaesthetics and therapeutic gases
0.707 0.293 0.000
Y47 Sedatives, hypnotics and antianxiety drugs
0.707 0.293 0.000
T84.0 Mechanical complication of internal joint prosthesis
0.707 0.293 0.000
B00-B09 Viral infections characterized by skin and mucous membrane lesions
0.707 0.293 0.000
I74.2 Embolism and thrombosis of arteries of the upper extremities
0.706 0.293 0.000
T85.4 Mechanical complication of breast prosthesis and implant
0.706 0.294 0.000
Y44 Agents primarily affecting blood constituents
0.706 0.294 0.000
T88 Other complications of surgical and medical care, not elsewhere classified
0.705 0.294 0.000
T78.4 Allergy, unspecified
0.705 0.295 0.000
S96 Injury of muscle and tendon at ankle and foot level
0.705 0.295 0.000
E28.2 Polycystic ovarian syndrome
0.705 0.295 0.000
D50-D53 Nutritional anaemias
0.704 0.296 0.001
A30-A49 Other bacterial diseases
0.704 0.296 0.000
L89 Decubitus ulcer
0.704 0.296 0.000
M34 Systemic sclerosis
0.704 0.296 0.000
T84.5 Infection and inflammatory reaction due to internal joint prosthesis
0.703 0.297 0.000
Z74.1 Need for assistance with personal care
0.703 0.297 0.000
B65-B83 Helminthiases
0.703 0.297 0.000
E87.7 Fluid overload
0.702 0.298 0.000
W50-W64 Exposure to animate mechanical forces
0.702 0.298 0.000
I77.0 Arteriovenous fistula, acquired
0.701 0.298 0.000
Z35.1 Supervision of pregnancy with history of abortive outcome
0.701 0.299 0.000
E35 Disorders of endocrine glands in diseases classified elsewhere
0.700 0.300 0.000
E32 Diseases of thymus
0.700 0.300 0.000
E31 Polyglandular dysfunction
0.700 0.300 0.000
E30 Disorders of puberty, not elsewhere classified
0.700 0.300 0.000
E25 Adrenogenital disorders
0.700 0.300 0.000
E20 Hypoparathyroidism
0.700 0.300 0.000
E67 Other hyperalimentation
0.699 0.300 0.000
E68 Sequelae of hyperalimentation
0.699 0.300 0.000
I77.5 Necrosis of artery
0.699 0.300 0.000
I77.4 Coeliac artery compression syndrome
0.699 0.300 0.000
I77.3 Arterial fibromuscular dysplasia
0.699 0.300 0.000
I77.2 Rupture of artery
0.699 0.300 0.000
R47 Speech disturbances, not elsewhere classified
0.699 0.301 0.000
S86 Injury of muscle and tendon at lower leg level
0.699 0.301 0.000
Q10-Q18 Congenital malformations of eye, ear, face and neck
0.699 0.301 0.000
S81 Open wound of lower leg
0.698 0.302 0.000
M05.90 Seropositive rheumatoid arthritis, unspecified (Multiple sites)
0.698 0.302 0.000
I95.2 Hypotension due to drugs
0.698 0.302 0.000
T84.4 Mechanical complication of other internal orthopaedic devices, imnplants and grafts
0.698 0.302 0.000
M79.2 Neuralgia and neuritis, unspecified
0.696 0.304 0.000
M22.8 Other disorders of patella
0.696 0.304 0.000
Z75 Problems related to medical facilities and other health care
0.695 0.305 0.000
M19.0 Primary arthrosis of other joints
0.694 0.306 0.000
Y45.3 Other nonsteroidal anti-inflammatory drugs [NSAID]
0.693 0.307 0.000
M25.31 Other instability of joint (Shoulder region)
0.693 0.307 0.000
E23.0 Hypopituitarism
0.693 0.307 0.000
L50-L54 Urticaria and erythema
0.693 0.307 0.000
Z74.2 Need for assistance at home and no other household member able to render care
0.692 0.308 0.000
Y51 Drugs primarily affecting the autonomic nervous system
0.691 0.309 0.000
Y45.2 Propionic acid derivatives
0.691 0.309 0.000
I74.9 Embolism and thrombosis of unspecified artery
0.690 0.310 0.000
I74.4 Embolism and thrombosis of arteries of extremities, unspecified
0.690 0.310 0.000
I74.1 Embolism and thrombosis of other and unspecified parts of aorta
0.690 0.310 0.000
I74.0 Embolism and thrombosis of abdominal aorta
0.690 0.310 0.000
Z31.2 In vitro fertilisation
0.690 0.310 0.000
L08 Other local infections of skin and subcutaneous tissue
0.690 0.310 0.000
M79.80 Other specified soft tissue disorders (Multiple sites)
0.690 0.310 0.000
E85 Amyloidosis
0.689 0.310 0.000
A80-A89 Viral infections of the central nervous system
0.689 0.311 0.000
T78.3 Angioneurotic oedema
0.689 0.311 0.000
X20-X29 Contact with venomous animals and plants
0.688 0.312 0.000
E66.2 Extreme obesity with alveolar hypoventilation
0.687 0.313 0.000
E66.1 Drug-induced obesity
0.687 0.313 0.000
Y42.6 Antigonadotrophins, antioestrogens, antiandrogens, not elsewhere classified
0.687 0.313 0.000
E74 Other disorders of carbohydrate metabolism
0.686 0.314 0.000
M25.52 Pain in joint (Upper arm)
0.686 0.314 0.000
M19.92 Arthrosis, unspecified (Upper arm)
0.685 0.315 0.000
E22 Hyperfunction of pituitary gland
0.685 0.315 0.000
E26 Hyperaldosteronism
0.684 0.316 0.000
E40-E46 Malnutrition
0.683 0.317 0.000
T80 Complications following infusion, transfusion and therapeutic injection
0.683 0.317 0.000
M66 Spontaneous rupture of synovium and tendon
0.682 0.317 0.000
M25.87 Other specified joint disorders (Ankle and foot)
0.681 0.319 0.000
Z34.8 Supervision of other normal pregnancy
0.680 0.320 0.000
I98.2 Oesophageal varices in diseases classified elsewhere
0.680 0.320 0.000
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]
0.679 0.321 0.000
Y56 Topical agents primarily affecting skin and mucous membrane and ophthalmological, otorhinolaryngological and dental drugs
0.678 0.322 0.000
I08.1 Disorders of both mitral and tricuspid valves
0.678 0.322 0.000
E27.9 Disorder of adrenal gland, unspecified
0.678 0.322 0.000
I35 Nonrheumatic aortic valve disorders
0.678 0.322 0.000
D63.0 Anaemia in neoplastic disease
0.678 0.322 0.000
M25.84 Other specified joint disorders (Hand)
0.677 0.323 0.000
B96.5 Pseudomonas (aeruginosa)(mallei)(pseudomallei) as the cause of diseases classified to other chapters
0.676 0.324 0.000
M21.37 Wrist or foot drop (acquired) (Ankle and foot)
0.676 0.324 0.000
Y45.1 Salicylates
0.676 0.324 0.000
E23.7 Disorder of pituitary gland, unspecified
0.675 0.325 0.000
Z38 Liveborn infants according to place of birth
0.675 0.325 0.000
M25.79 Osteophyte (Site unspecified)
0.675 0.325 0.000
M25.73 Osteophyte (Forearm)
0.675 0.325 0.000
M25.70 Osteophyte (Multiple sites)
0.675 0.325 0.000
I38 Endocarditis, valve unspecified
0.675 0.325 0.000
S82.0 Fracture of patella
0.675 0.325 0.000
M25.45 Effusion of joint (Pelvic region and thigh)
0.673 0.326 0.000
Chapter VI Diseases of the nervous system
0.671 0.329 0.000
M05.99 Seropositive rheumatoid arthritis, unspecified (Site unspecified)
0.671 0.329 0.000
Chapter XXII Codes for special purposes
0.670 0.329 0.000
Y41 Other systemic anti-infectives and antiparasitics
0.670 0.330 0.000
M14 Arthropathies in other diseases classified elsewhere
0.670 0.330 0.000
M12 Other specific arthropathies
0.670 0.330 0.000
M09 Juvenile arthritis in diseases classified elsewhere
0.670 0.330 0.000
M08 Juvenile arthritis
0.670 0.330 0.000
D51 Vitamin B12 deficiency anaemia
0.669 0.330 0.000
M79.87 Other specified soft tissue disorders (Ankle and foot)
0.669 0.331 0.000
B98.0 Helicobacter pylori [H.pylori] as the cause of diseases classified to other chapters
0.669 0.331 0.000
X40-X49 Accidental poisoning by and exposure to noxious substances
0.669 0.331 0.000
M76 Enthesopathies of lower limb, excluding foot
0.669 0.331 0.000
M73 Soft tissue disorders in diseases classified elsewhere
0.669 0.331 0.000
Y52.9 Other and unspecified agents primarily affecting the cardiovascular system
0.668 0.331 0.000
Y52.8 Antivaricose drugs, including sclerosing agents
0.668 0.331 0.000
Y52.7 Peripheral vasodilators
0.668 0.331 0.000
Y52.6 Antihyperlipidaemic and antiarteriosclerotic drugs
0.668 0.331 0.000
Y52.0 Cardiac-stimulant glycosides and drugs of similar action
0.668 0.331 0.000
D64 Other anaemias
0.668 0.332 0.000
B85-B89 Pediculosis, acariasis and other infestations
0.668 0.332 0.000
B50-B64 Protozoal diseases
0.668 0.332 0.000
B20-B24 Human immunodeficiency virus [HIV] disease
0.668 0.332 0.000
A92-A99 Arthropod-borne viral fevers and viral haemorrhagic fevers
0.668 0.332 0.000
A75-A79 Rickettsioses
0.668 0.332 0.000
A70-A74 Other diseases caused by chlamydiae
0.668 0.332 0.000
A65-A69 Other spirochaetal diseases
0.668 0.332 0.000
A20-A28 Certain zoonotic bacterial diseases
0.668 0.332 0.000
A15-A19 Tuberculosis
0.668 0.332 0.000
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.668 0.332 0.000
T91 Sequelae of injuries of neck and trunk
0.668 0.332 0.000
M50-M54 Other dorsopathies
0.668 0.332 0.000
Z30.9 Contraceptive management, unspecified
0.667 0.332 0.000
Z30.4 Surveillance of contraceptive drugs
0.667 0.332 0.000
Z30.0 General counselling and advice on contraception
0.667 0.332 0.000
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.667 0.333 0.000
M25.76 Osteophyte (Lower leg)
0.666 0.334 0.000
I33.0 Acute and subacute infective endocarditis
0.665 0.334 0.000
E84 Cystic fibrosis
0.665 0.335 0.000
E79 Disorders of purine and pyrimidine metabolism
0.665 0.335 0.000
E77 Disorders of glycoprotein metabolism
0.665 0.335 0.000
E76 Disorders of glycosaminoglycan metabolism
0.665 0.335 0.000
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.665 0.335 0.000
E73 Lactose intolerance
0.665 0.335 0.000
E72 Other disorders of amino-acid metabolism
0.665 0.335 0.000
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.665 0.335 0.000
E70 Disorders of aromatic amino-acid metabolism
0.665 0.335 0.000
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.665 0.335 0.000
Z35.0 Supervision of pregnancy with history of infertility
0.665 0.335 0.000
T79.7 Traumatic subcutaneous emphysema
0.665 0.335 0.000
Y90 Evidence of alcohol involvement determined by blood alcohol level
0.665 0.335 0.000
Y98 Lifestyle-related condition
0.665 0.335 0.000
Y97 Environmental-pollution-related condition
0.665 0.335 0.000
Y96 Work-related condition
0.665 0.335 0.000
M40-M43 Deforming dorsopathies
0.664 0.335 0.000
I44.0 Atrioventricular block, first degree
0.663 0.337 0.000
M25.59 Pain in joint (Site unspecified)
0.663 0.337 0.000
M67 Other disorders of synovium and tendon
0.662 0.338 0.000
E87.8 Other disorders of electrolyte and fluid balance, not elsewhere classified
0.662 0.338 0.000
T84.2 Mechanical complication of internal fixation device of other bones
0.662 0.338 0.000
L84 Corns and callosities
0.662 0.338 0.000
Y42.3 Insulin and oral hypoglycaemic [antidiabetic] drugs
0.661 0.339 0.000
S92.0 Fracture of calcaneus
0.661 0.339 0.000
E87.4 Mixed disorder of acid-base balance
0.661 0.339 0.000
Z70 Counselling related to sexual attitude, behaviour and orientation
0.661 0.339 0.000
I44.7 Left bundle-branch block, unspecified
0.660 0.340 0.000
Q51.3 Bicornate uterus
0.660 0.340 0.000
M94 Other disorders of cartilage
0.660 0.340 0.000
M25.85 Other specified joint disorders (Pelvic region and thigh)
0.659 0.341 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.659 0.341 0.000
Z34.9 Supervision of normal pregnancy, unspecified
0.659 0.341 0.000
Z71.9 Counselling, unspecified
0.659 0.341 0.000
E27.8 Other specified disorders of adrenal gland
0.657 0.343 0.000
I73.8 Other specified peripheral vascular diseases
0.657 0.343 0.000
I73.1 Thromboangiitis obliterans [Buerger]
0.657 0.343 0.000
B90-B94 Sequelae of infectious and parasitic diseases
0.657 0.343 0.000
A00-A09 Intestinal infectious diseases
0.657 0.343 0.000
M25.89 Other specified joint disorders (Site unspecified)
0.657 0.343 0.000
M25.88 Other specified joint disorders (Other)
0.657 0.343 0.000
M25.82 Other specified joint disorders (Upper arm)
0.657 0.343 0.000
M25.81 Other specified joint disorders (Shoulder region)
0.657 0.343 0.000
M25.80 Other specified joint disorders (Multiple sites)
0.657 0.343 0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.656 0.344 0.000
I60-I69 Cerebrovascular diseases
0.656 0.344 0.000
M23 Internal derangement of knee
0.656 0.344 0.000
M19.98 Arthrosis, unspecified (Other)
0.655 0.345 0.000
Y40.3 Macrolides
0.654 0.346 0.000
Q80-Q89 Other congenital malformations
0.654 0.346 0.000
I98.3 Oesophageal varices with bleeding in diseases classified elsewhere
0.653 0.347 0.000
R49 Voice disturbances
0.653 0.347 0.000
M96.0 Pseudarthrosis after fusion or arthrodesis
0.652 0.348 0.000
T84.9 Unspecified complication of internal orthopaedic prosthetic device, implant and graft
0.652 0.348 0.000
T84.3 Mechanical complication of other bone devices, implants and grafts
0.652 0.348 0.000
R47.0 Dysphasia and aphasia
0.652 0.348 0.000
I79.2 Peripheral angiopathy in diseases classified elsewhere
0.650 0.349 0.000
M70 Soft tissue disorders related to use, overuse and pressure
0.650 0.350 0.000
Y40.1 Cefalosporins and other -lactam antibiotics
0.650 0.350 0.000
M79.9 Soft tissue disorder, unspecified
0.650 0.350 0.000
M79.4 Hypertrophy of (infrapatellar) fat pad
0.650 0.350 0.000
M79.3 Panniculitis, unspecified
0.650 0.350 0.000
M79.62 Pain in limb (Upper arm)
0.650 0.350 0.000
T75 Effects of other external causes
0.649 0.351 0.000
T74 Maltreatment syndromes
0.649 0.351 0.000
T73 Effects of other deprivation
0.649 0.351 0.000
T70 Effects of air pressure and water pressure
0.649 0.351 0.000
T69 Other effects of reduced temperature
0.649 0.351 0.000
T67 Effects of heat and light
0.649 0.351 0.000
T66 Unspecified effects of radiation
0.649 0.351 0.000
Q20-Q28 Congenital malformations of the circulatory system
0.649 0.351 0.000
S90 Superficial injury of ankle and foot
0.648 0.352 0.000
M25.49 Effusion of joint (Site unspecified)
0.647 0.353 0.000
M25.48 Effusion of joint (Other)
0.647 0.353 0.000
M25.44 Effusion of joint (Hand)
0.647 0.353 0.000
M25.43 Effusion of joint (Forearm)
0.647 0.353 0.000
M25.42 Effusion of joint (Upper arm)
0.647 0.353 0.000
M25.41 Effusion of joint (Shoulder region)
0.647 0.353 0.000
M25.40 Effusion of joint (Multiple sites)
0.647 0.353 0.000
S98 Traumatic amputation of ankle and foot
0.647 0.353 0.000
S97 Crushing injury of ankle and foot
0.647 0.353 0.000
S95 Injury of blood vessels at ankle and foot level
0.647 0.353 0.000
S94 Injury of nerves at ankle and foot level
0.647 0.353 0.000
S93 Dislocation, sprain and strain of joints and ligaments at ankle and foot level
0.647 0.353 0.000
L83 Acanthosis nigricans
0.647 0.353 0.000
M11 Other crystal arthropathies
0.647 0.353 0.000
M24.5 Contracture of joint
0.646 0.353 0.000
D55-D59 Haemolytic anaemias
0.646 0.353 0.000
Z32 Pregnancy examination and test
0.646 0.354 0.000
M93.9 Osteochondropathy, unspecified
0.646 0.354 0.000
V18 Pedal cyclist injured in noncollision transport accident
0.645 0.355 0.000
E87.3 Alkalosis
0.645 0.355 0.000
Z73.9 Problem related to life-management difficulty, unspecified
0.643 0.356 0.000
S82.1 Fracture of upper end of tibia
0.643 0.357 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.643 0.357 0.000
V17 Pedal cyclist injured in collision with fixed or stationary object
0.643 0.357 0.000
L89.1 Stage II decubitus ulcer
0.642 0.358 0.000
T85.3 Mechanical complication of other ocular prosthetic devices, imnplants and grafts
0.642 0.358 0.000
Z74.9 Problem related to care-provider dependency, unspecified
0.641 0.358 0.000
Z74.8 Other problems related to care-provider dependency
0.641 0.358 0.000
Z74.3 Need for continuous supervision
0.641 0.358 0.000
M24.2 Disorder of ligament
0.641 0.358 0.000
E53 Deficiency of other B group vitamins
0.641 0.359 0.000
M25.06 Haemarthrosis (Lower leg)
0.640 0.360 0.000
Y40.8 Other systemic antibiotics
0.640 0.360 0.000
M79.89 Other specified soft tissue disorders (Site unspecified)
0.639 0.360 0.000
I44.3 Other and unspecified atrioventricular block
0.639 0.361 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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