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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs1899875
log Bayes Factor = 15.3034
Chromosome 21   position 22,669,522  (GRCh37) Explore rs1899875 on Ensembl!
Variant rs1899875 is part of Cluster X0170

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
I30-I52 Other forms of heart disease
1.000 0.000 0.000
# Top node
1.000 0.000 0.000
Chapter IX Diseases of the circulatory system
1.000 0.000 0.000
K80-K87 Disorders of gallbladder, biliary tract and pancreas
1.000 0.000 0.000
Chapter XIV Diseases of the genitourinary system
1.000 0.000 0.000
K80.1 Calculus of gallbladder with other cholecystitis
1.000 0.000 0.000
K80 Cholelithiasis
0.999 0.001 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.999 0.001 0.000
Chapter XI Diseases of the digestive system
0.998 0.002 0.000
N10-N16 Renal tubulo-interstitial diseases
0.998 0.002 0.000
I05-I09 Chronic rheumatic heart diseases
0.997 0.003 0.000
N13 Obstructive and reflux uropathy
0.993 0.007 0.000
M15-M19 Arthrosis
0.990 0.010 0.000
M19 Other arthrosis
0.989 0.011 0.000
Chapter VI Diseases of the nervous system
0.988 0.012 0.000
Chapter I Certain infectious and parasitic diseases
0.987 0.013 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.986 0.014 0.000
I49 Other cardiac arrhythmias
0.984 0.016 0.000
E70-E90 Metabolic disorders
0.984 0.016 0.000
E86 Volume depletion
0.983 0.017 0.000
M19.9 Arthrosis, unspecified
0.982 0.018 0.000
I08 Multiple valve diseases
0.982 0.018 0.000
Chapter XXII Codes for special purposes
0.972 0.028 0.000
I51 Complications and ill-defined descriptions of heart disease
0.972 0.028 0.000
K83 Other diseases of biliary tract
0.971 0.029 0.000
N60-N64 Disorders of breast
0.970 0.030 0.000
I49.9 Cardiac arrhythmia, unspecified
0.968 0.032 0.000
I08.3 Combined disorders of mitral, aortic and tricuspid valves
0.967 0.033 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
0.956 0.044 0.000
M19.96 Arthrosis, unspecified-Lower leg
0.955 0.045 0.000
M20-M25 Other joint disorders
0.954 0.046 0.000
I34 Nonrheumatic mitral valve disorders
0.945 0.055 0.000
A30-A49 Other bacterial diseases
0.944 0.056 0.000
G40-G47 Episodic and paroxysmal disorders
0.943 0.057 0.000
I38 Endocarditis, valve unspecified
0.943 0.057 0.000
N13.9 Obstructive and reflux uropathy, unspecified
0.934 0.066 0.000
U82-U85 Resistance to antimicrobial and antineoplastic drugs
0.932 0.068 0.000
N13.3 Other and unspecified hydronephrosis
0.931 0.069 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.930 0.070 0.000
M19.0 Primary arthrosis of other joints
0.924 0.076 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.922 0.078 0.000
N25-N29 Other disorders of kidney and ureter
0.918 0.082 0.000
K82 Other diseases of gallbladder
0.918 0.082 0.000
I05 Rheumatic mitral valve diseases
0.916 0.084 0.000
E87 Other disorders of fluid, electrolyte and acid-base balance
0.914 0.086 0.000
I70-I79 Diseases of arteries, arterioles and capillaries
0.910 0.090 0.000
N62 Hypertrophy of breast
0.909 0.091 0.000
G50-G59 Nerve, nerve root and plexus disorders
0.905 0.095 0.000
B00-B09 Viral infections characterized by skin and mucous membrane lesions
0.904 0.096 0.000
G20-G26 Extrapyramidal and movement disorders
0.903 0.097 0.000
N63 Unspecified lump in breast
0.902 0.098 0.000
Chapter XX External causes of morbidity and mortality
0.897 0.103 0.000
K65-K67 Diseases of peritoneum
0.895 0.105 0.000
E87.6 Hypokalaemia
0.894 0.106 0.000
I51.7 Cardiomegaly
0.893 0.107 0.000
E20-E35 Disorders of other endocrine glands
0.887 0.113 0.000
M19.99 Arthrosis, unspecified (Site unspecified)
0.884 0.116 0.000
G45 Transient cerebral ischaemic attacks and related syndromes
0.879 0.121 0.000
K86 Other diseases of pancreas
0.876 0.124 0.000
K82.4 Cholesterolosis of gallbladder
0.872 0.128 0.000
K83.0 Cholangitis
0.872 0.128 0.000
Chapter II Neoplasms
0.870 0.130 0.000
G25 Other extrapyramidal and movement disorders
0.870 0.130 0.000
N13.7 Vesicoureteral-reflux-associated uropathy
0.867 0.133 0.000
I07 Rheumatic tricuspid valve diseases
0.866 0.134 0.000
N10 Acute tubulo-interstitial nephritis
0.864 0.136 0.000
T66-T78 Other and unspecified effects of external causes
0.862 0.138 0.000
I50 Heart failure
0.862 0.138 0.000
T92 Sequelae of injuries of upper limb
0.862 0.138 0.000
G47 Sleep disorders
0.861 0.139 0.000
I34.0 Mitral (valve) insufficiency
0.861 0.139 0.000
G56 Mononeuropathies of upper limb
0.861 0.139 0.000
M65-M68 Disorders of synovium and tendon
0.858 0.142 0.000
U88 Agent resistant to multiple antibiotics
0.858 0.142 0.000
M19.94 Arthrosis, unspecified (Hand)
0.858 0.142 0.000
M35 Other systemic involvement of connective tissue
0.857 0.143 0.000
N60 Benign mammary dysplasia
0.856 0.144 0.000
I49.8 Other specified cardiac arrhythmias
0.855 0.145 0.000
N13.1 Hydronephrosis with ureteral stricture, not elsewhere classified
0.853 0.147 0.000
K83.1 Obstruction of bile duct
0.851 0.149 0.000
M86-M90 Other osteopathies
0.851 0.149 0.000
I49.1 Atrial premature depolarisation
0.850 0.149 0.000
C15-C26 Malignant neoplasms of digestive organs
0.850 0.150 0.000
M25 Other joint disorders, not elsewhere classified
0.849 0.151 0.000
A00-A09 Intestinal infectious diseases
0.848 0.152 0.000
N12 Tubulo-interstitial nephritis, not specified as acute or chronic
0.847 0.153 0.000
S80-S89 Injuries to the knee and lower leg
0.847 0.153 0.000
G45.9 Transient cerebral ischaemic attack, unspecified
0.843 0.157 0.000
I46 Cardiac arrest
0.842 0.158 0.000
K83.8 Other specified diseases of biliary tract
0.840 0.160 0.000
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system
0.840 0.160 0.000
A40 Streptococcal septicaemia
0.839 0.161 0.000
I47 Paroxysmal tachycardia
0.836 0.164 0.000
N28 Other disorders of kidney and ureter, not elsewhere classified
0.836 0.164 0.000
M22 Disorders of patella
0.834 0.166 0.000
U00-U49 Provisional assignment of new diseases of uncertain etiology or emergency use
0.833 0.167 0.000
D37-D48 Neoplasms of uncertain or unknown behaviour
0.831 0.169 0.000
U89 Agent resistant to other and unspecified antibiotics
0.829 0.171 0.000
M19.01 Primary arthrosis of other joints (Shoulder region)
0.828 0.172 0.000
N17-N19 Renal failure
0.828 0.172 0.000
G56.0 Carpal tunnel syndrome
0.827 0.173 0.000
K00-K14 Diseases of oral cavity, salivary glands and jaws
0.827 0.173 0.000
N99-N99 Other disorders of the genitourinary system
0.822 0.178 0.000
I08.2 Disorders of both aortic and tricuspid valves
0.821 0.179 0.000
K80.4 Calculus of bile duct with cholecystitis
0.820 0.179 0.000
N60.2 Fibroadenosis of breast
0.819 0.181 0.000
K81 Cholecystitis
0.817 0.183 0.000
E87.5 Hyperkalaemia
0.817 0.183 0.000
M15 Polyarthrosis
0.816 0.184 0.000
M19.91 Arthrosis, unspecified (Shoulder region)
0.814 0.186 0.000
I33 Acute and subacute endocarditis
0.814 0.186 0.000
A49 Bacterial infection of unspecified site
0.812 0.188 0.000
E23 Hypofunction and other disorders of pituitary gland
0.810 0.190 0.000
I44 Atrioventricular and left bundle-branch block
0.809 0.191 0.000
G25.8 Other specified extrapyramidal and movement disorders
0.807 0.193 0.000
S10-S19 Injuries to the neck
0.806 0.194 0.000
M35.3 Polymyalgia rheumatica
0.805 0.195 0.000
I51.9 Heart disease, unspecified
0.804 0.196 0.000
K66 Other disorders of peritoneum
0.804 0.196 0.000
G58 Other mononeuropathies
0.804 0.196 0.000
I71 Aortic aneurysm and dissection
0.803 0.197 0.000
S60-S69 Injuries to the wrist and hand
0.800 0.200 0.000
I34.1 Mitral (valve) prolapse
0.798 0.202 0.000
S80 Superficial injury of lower leg
0.797 0.203 0.000
M19.1 Posttraumatic arthrosis of other joints
0.797 0.203 0.000
I08.0 Disorders of both mitral and aortic valves
0.796 0.204 0.000
I51.8 Other ill-defined heart diseases
0.793 0.207 0.000
Q20-Q28 Congenital malformations of the circulatory system
0.793 0.207 0.000
X60-X84 Intentional self-harm
0.791 0.209 0.000
Y90-Y98 Supplementary factors related to causes of morbidity and mortality classified elsewhere
0.790 0.210 0.000
N13.0 Hydronephrosis with ureteropelvic junction obstruction
0.788 0.212 0.000
G25.0 Essential tremor
0.787 0.213 0.000
T91 Sequelae of injuries of neck and trunk
0.786 0.214 0.000
M25.4 Effusion of joint
0.786 0.214 0.000
I05.1 Rheumatic mitral insufficiency
0.784 0.216 0.000
T78 Adverse effects, not elsewhere classified
0.784 0.216 0.000
M05-M14 Inflammatory polyarthropathies
0.784 0.216 0.000
M30 Polyarteritis nodosa and related conditions
0.783 0.217 0.000
M24 Other specific joint derangements
0.782 0.217 0.000
G80-G83 Cerebral palsy and other paralytic syndromes
0.782 0.218 0.000
I50.9 Heart failure, unspecified
0.779 0.221 0.000
D41 Neoplasm of uncertain or unknown behaviour of urinary organs
0.777 0.223 0.000
E73 Lactose intolerance
0.777 0.223 0.000
I30 Acute pericarditis
0.776 0.224 0.000
I51.0 Cardiac septal defect, acquired
0.773 0.227 0.000
A09 Diarrhoea and gastro-enteritis of presumed infectious origin
0.773 0.227 0.000
S50-S59 Injuries to the elbow and forearm
0.772 0.228 0.000
I07.1 Tricuspid insufficiency
0.771 0.229 0.000
I05.9 Mitral valve disease, unspecified
0.770 0.230 0.000
T92.1 Sequelae of fracture of arm
0.769 0.231 0.000
Q80-Q89 Other congenital malformations
0.769 0.231 0.000
C20 Malignant neoplasm of rectum
0.769 0.231 0.000
K05 Gingivitis and periodontal diseases
0.767 0.233 0.000
I42 Cardiomyopathy
0.765 0.235 0.000
I31 Other diseases of pericardium
0.764 0.236 0.000
A46 Erysipelas
0.763 0.237 0.000
Chapter XII Diseases of the skin and subcutaneous tissue
0.763 0.237 0.000
I46.0 Cardiac arrest with successful resuscitation
0.762 0.238 0.000
M65 Synovitis and tenosynovitis
0.761 0.239 0.000
K04 Diseases of pulp and periapical tissues
0.760 0.240 0.000
N28.1 Cyst of kidney, acquired
0.757 0.243 0.000
I71.2 Thoracic aortic aneurysm, without mention of rupture
0.757 0.243 0.000
U89.8 Agent resistant to other single specified antibiotic
0.756 0.244 0.000
N20-N23 Urolithiasis
0.756 0.244 0.000
G70-G73 Diseases of myoneural junction and muscle
0.754 0.246 0.000
B90-B94 Sequelae of infectious and parasitic diseases
0.754 0.246 0.000
B02 Zoster [herpes zoster]
0.753 0.247 0.000
I74 Arterial embolism and thrombosis
0.752 0.248 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.751 0.249 0.000
K86.8 Other specified diseases of pancreas
0.751 0.249 0.000
I37 Pulmonary valve disorders
0.751 0.249 0.000
I49.4 Other and unspecified premature depolarisation
0.750 0.250 0.000
M19.09 Primary arthrosis of other joints (Site unspecified)
0.749 0.251 0.000
B07 Viral warts
0.748 0.252 0.000
C19 Malignant neoplasm of rectosigmoid junction
0.748 0.252 0.000
M25.46 Effusion of joint (Lower leg)
0.748 0.252 0.000
N13.5 Kinking and stricture of ureter without hydronephrosis
0.747 0.253 0.000
S80.9 Superficial injury of lower leg, unspecified
0.747 0.253 0.000
N19 Unspecified renal failure
0.747 0.253 0.000
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx
0.746 0.254 0.000
E74 Other disorders of carbohydrate metabolism
0.746 0.254 0.000
G53 Cranial nerve disorders in diseases classified elsewhere
0.746 0.254 0.000
I10-I15 Hypertensive diseases
0.746 0.254 0.000
M25.6 Stiffness of joint, not elsewhere classified
0.745 0.255 0.000
Q60-Q64 Congenital malformations of the urinary system
0.744 0.256 0.000
C18 Malignant neoplasm of colon
0.742 0.258 0.000
M60-M63 Disorders of muscles
0.741 0.259 0.000
N40-N51 Diseases of male genital organs
0.741 0.259 0.000
M32 Systemic lupus erythematosus
0.740 0.260 0.000
K80.0 Calculus of gallbladder with acute cholecystitis
0.739 0.261 0.000
B00 Herpesviral [herpes simplex] infections
0.739 0.261 0.000
K66.0 Peritoneal adhesions
0.738 0.262 0.000
C50-C50 Malignant neoplasm of breast
0.737 0.263 0.000
I36 Nonrheumatic tricuspid valve disorders
0.737 0.263 0.000
G62 Other polyneuropathies
0.736 0.264 0.000
X40-X49 Accidental poisoning by and exposure to noxious substances
0.736 0.264 0.000
M19.07 Primary arthrosis of other joints (Ankle and foot)
0.734 0.266 0.000
B35-B49 Mycoses
0.734 0.266 0.000
A09.9 Gastroenteritis and colitis of unspecified origin
0.733 0.267 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.733 0.267 0.000
N25 Disorders resulting from impaired renal tubular function
0.732 0.268 0.000
U80 Agent resistant to penicillin and related antibiotics
0.732 0.268 0.000
I50.0 Congestive heart failure
0.731 0.269 0.000
G47.3 Sleep apnoea
0.731 0.269 0.000
M19.90 Arthrosis, unspecified (Multiple sites)
0.729 0.271 0.000
I77 Other disorders of arteries and arterioles
0.728 0.272 0.000
M70-M79 Other soft tissue disorders
0.728 0.272 0.000
M91-M94 Chondropathies
0.727 0.273 0.000
I45 Other conduction disorders
0.726 0.274 0.000
D41.4 Bladder
0.724 0.276 0.000
G59 Mononeuropathy in diseases classified elsewhere
0.722 0.278 0.000
Q50-Q56 Congenital malformations of genital organs
0.722 0.278 0.000
I51.6 Cardiovascular disease, unspecified
0.722 0.278 0.000
B15-B19 Viral hepatitis
0.721 0.278 0.000
K86.3 Pseudocyst of pancreas
0.720 0.280 0.000
I34.9 Nonrheumatic mitral valve disorder, unspecified
0.720 0.280 0.000
X50-X57 Overexertion, travel and privation
0.719 0.281 0.000
V40-V49 Car occupant injured in transport accident
0.718 0.282 0.000
K86.2 Cyst of pancreas
0.717 0.283 0.000
I52 Other heart disorders in diseases classified elsewhere
0.717 0.283 0.000
I48 Atrial fibrillation and flutter
0.717 0.283 0.000
I43 Cardiomyopathy in diseases classified elsewhere
0.717 0.283 0.000
I41 Myocarditis in diseases classified elsewhere
0.717 0.283 0.000
I40 Acute myocarditis
0.717 0.283 0.000
I39 Endocarditis and heart valve disorders in diseases classified elsewhere
0.717 0.283 0.000
I32 Pericarditis in diseases classified elsewhere
0.717 0.283 0.000
I00-I02 Acute rheumatic fever
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
T78.3 Angioneurotic oedema
0.717 0.283 0.000
K87 Disorders of gallbladder, biliary tract and pancreas in diseases classified elsewhere
0.717 0.283 0.000
K80.3 Calculus of bile duct with cholangitis
0.716 0.284 0.000
M40-M43 Deforming dorsopathies
0.716 0.284 0.000
M00-M03 Infectious arthropathies
0.716 0.284 0.000
N16 Renal tubulo-interstitial disorders in diseases classified elsewhere
0.715 0.285 0.000
N15 Other renal tubulo-interstitial diseases
0.715 0.285 0.000
N14 Drug- and heavy-metal-induced tubulo-interstitial and tubular conditions
0.715 0.285 0.000
I09 Other rheumatic heart diseases
0.715 0.285 0.000
I06 Rheumatic aortic valve diseases
0.715 0.285 0.000
B65-B83 Helminthiases
0.715 0.285 0.000
I05.2 Mitral stenosis with insufficiency
0.713 0.287 0.000
I72 Other aneurysm
0.712 0.288 0.000
M80-M85 Disorders of bone density and structure
0.712 0.288 0.000
M19.92 Arthrosis, unspecified (Upper arm)
0.712 0.288 0.000
N48 Other disorders of penis
0.712 0.288 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.711 0.289 0.000
N00-N08 Glomerular diseases
0.710 0.290 0.000
M19.8 Other specified arthrosis
0.709 0.291 0.000
M19.2 Other secondary arthrosis
0.709 0.291 0.000
C18.7 Sigmoid colon
0.709 0.291 0.000
A40.8 Other streptococcal septicaemia
0.708 0.292 0.000
D39 Neoplasm of uncertain or unknown behaviour of female genital organs
0.708 0.292 0.000
B99-B99 Other infectious diseases
0.708 0.292 0.000
B85-B89 Pediculosis, acariasis and other infestations
0.708 0.292 0.000
B50-B64 Protozoal diseases
0.708 0.292 0.000
A92-A99 Arthropod-borne viral fevers and viral haemorrhagic fevers
0.708 0.292 0.000
A75-A79 Rickettsioses
0.708 0.292 0.000
A70-A74 Other diseases caused by chlamydiae
0.708 0.292 0.000
A65-A69 Other spirochaetal diseases
0.708 0.292 0.000
A20-A28 Certain zoonotic bacterial diseases
0.708 0.292 0.000
A15-A19 Tuberculosis
0.708 0.292 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.708 0.292 0.000
K80.8 Other cholelithiasis
0.708 0.292 0.000
I49.5 Sick sinus syndrome
0.707 0.293 0.000
A41 Other septicaemia
0.707 0.293 0.000
I49.2 Junctional premature depolarisation
0.706 0.294 0.000
M19.95 Arthrosis, unspecified (Pelvic region and thigh)
0.706 0.294 0.000
E85 Amyloidosis
0.705 0.294 0.000
E84 Cystic fibrosis
0.705 0.294 0.000
E79 Disorders of purine and pyrimidine metabolism
0.705 0.294 0.000
E77 Disorders of glycoprotein metabolism
0.705 0.294 0.000
E76 Disorders of glycosaminoglycan metabolism
0.705 0.294 0.000
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.705 0.294 0.000
E72 Other disorders of amino-acid metabolism
0.705 0.294 0.000
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.705 0.294 0.000
E70 Disorders of aromatic amino-acid metabolism
0.705 0.294 0.000
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.705 0.294 0.000
S20-S29 Injuries to the thorax
0.705 0.295 0.000
B95-B98 Bacterial, viral and other infectious agents
0.705 0.295 0.000
M90 Osteopathies in diseases classified elsewhere
0.704 0.296 0.000
I08.9 Multiple valve disease, unspecified
0.704 0.296 0.000
Y95 Nosocomial condition
0.704 0.296 0.000
M22.8 Other disorders of patella
0.704 0.296 0.000
N28.0 Ischaemia and infarction of kidney
0.703 0.297 0.000
T79-T79 Certain early complications of trauma
0.703 0.297 0.000
T93 Sequelae of injuries of lower limb
0.703 0.297 0.000
G47.8 Other sleep disorders
0.702 0.298 0.000
T92.9 Sequelae of unspecified injury of upper limb
0.702 0.298 0.000
K70-K77 Diseases of liver
0.701 0.299 0.000
G41 Status epilepticus
0.701 0.299 0.000
K81.9 Cholecystitis, unspecified
0.700 0.300 0.000
M34 Systemic sclerosis
0.697 0.303 0.000
I51.5 Myocardial degeneration
0.696 0.303 0.000
I51.4 Myocarditis, unspecified
0.696 0.303 0.000
I51.3 Intracardiac thrombosis, not elsewhere classified
0.696 0.303 0.000
I51.2 Rupture of papillary muscle, not elsewhere classified
0.696 0.303 0.000
I51.1 Rupture of chordae tendineae, not elsewhere classified
0.696 0.303 0.000
G58.9 Mononeuropathy, unspecified
0.697 0.303 0.000
K83.9 Disease of biliary tract, unspecified
0.696 0.304 0.000
K83.5 Biliary cyst
0.696 0.304 0.000
K83.4 Spasm of sphincter of Oddi
0.696 0.304 0.000
K83.3 Fistula of bile duct
0.696 0.304 0.000
K83.2 Perforation of bile duct
0.696 0.304 0.000
I12 Hypertensive renal disease
0.695 0.305 0.000
N99 Postprocedural disorders of genito-urinary system, not elsewhere classified
0.694 0.306 0.000
K82.9 Disease of gallbladder, unspecified
0.693 0.307 0.000
D37 Neoplasm of uncertain or unknown behaviour of oral cavity and digestive organs
0.691 0.309 0.000
T92.2 Sequelae of fracture at wrist and hand level
0.690 0.309 0.000
K65 Peritonitis
0.689 0.311 0.000
M07 Psoriatic and enteropathic arthropathies
0.689 0.311 0.000
I44.2 Atrioventricular block, complete
0.689 0.311 0.000
E23.0 Hypopituitarism
0.688 0.312 0.000
N28.9 Disorder of kidney and ureter, unspecified
0.688 0.312 0.000
Q21 Congenital malformations of cardiac septa
0.687 0.313 0.000
A49.8 Other bacterial infections of unspecified site
0.687 0.313 0.000
Q00-Q07 Congenital malformations of the nervous system
0.687 0.313 0.000
N13.2 Hydronephrosis with renal and ureteral calculous obstruction
0.686 0.314 0.000
B20-B24 Human immunodeficiency virus [HIV] disease
0.685 0.315 0.000
T33-T35 Frostbite
0.685 0.315 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.685 0.315 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.685 0.315 0.000
T00-T07 Injuries involving multiple body regions
0.685 0.315 0.000
I47.9 Paroxysmal tachycardia, unspecified
0.685 0.315 0.000
M65.3 Trigger finger
0.685 0.315 0.000
G45.8 Other transient cerebral ischaemic attacks and related syndromes
0.684 0.316 0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.684 0.316 0.000
M33 Dermatopolymyositis
0.684 0.316 0.000
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.682 0.318 0.000
T90 Sequelae of injuries of head
0.682 0.318 0.000
C64-C68 Malignant neoplasms of urinary tract
0.681 0.319 0.000
K04.5 Chronic apical periodontitis
0.681 0.319 0.000
L40-L45 Papulosquamous disorders
0.680 0.320 0.000
I33.0 Acute and subacute infective endocarditis
0.680 0.320 0.000
I08.8 Other multiple valve diseases
0.680 0.320 0.000
M19.97 Arthrosis, unspecified (Ankle and foot)
0.680 0.320 0.000
M22.2 Patellofemoral disorders
0.678 0.321 0.000
I34.8 Other nonrheumatic mitral valve disorders
0.678 0.322 0.000
I34.2 Nonrheumatic mitral (valve) stenosis
0.678 0.322 0.000
A48 Other bacterial diseases, not elsewhere classified
0.677 0.323 0.000
A44 Bartonellosis
0.677 0.323 0.000
A43 Nocardiosis
0.677 0.323 0.000
A42 Actinomycosis
0.677 0.323 0.000
A39 Meningococcal infection
0.677 0.323 0.000
A37 Whooping cough
0.677 0.323 0.000
A36 Diphtheria
0.677 0.323 0.000
A32 Listeriosis
0.677 0.323 0.000
A31 Infection due to other mycobacteria
0.677 0.323 0.000
A30 Leprosy [Hansen's disease]
0.677 0.323 0.000
A38 Scarlet fever
0.677 0.323 0.000
A35 Other tetanus
0.677 0.323 0.000
A34 Obstetrical tetanus
0.677 0.323 0.000
A33 Tetanus neonatorum
0.677 0.323 0.000
G46 Vascular syndromes of brain in cerebrovascular diseases
0.676 0.324 0.000
N13.6 Pyonephrosis
0.676 0.324 0.000
I47.1 Supraventricular tachycardia
0.676 0.324 0.000
G44 Other headache syndromes
0.675 0.325 0.000
M18 Arthrosis of first carpometacarpal joint
0.674 0.326 0.000
A40.3 Septicaemia due to Streptococcus pneumoniae
0.672 0.328 0.000
N60.4 Mammary duct ectasia
0.672 0.328 0.000
V20-V29 Motorcycle rider injured in transport accident
0.672 0.328 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.672 0.328 0.000
A80-A89 Viral infections of the central nervous system
0.671 0.329 0.000
E26 Hyperaldosteronism
0.671 0.329 0.000
L50-L54 Urticaria and erythema
0.670 0.330 0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.670 0.330 0.000
S60 Superficial injury of wrist and hand
0.669 0.331 0.000
V80-V89 Other land transport accidents
0.668 0.332 0.000
E10-E14 Diabetes mellitus
0.668 0.332 0.000
U84 Resistance to other antimicrobial drugs
0.668 0.332 0.000
U83 Resistance to other antibiotics
0.668 0.332 0.000
U82 Resistance to betalactam antibiotics
0.668 0.332 0.000
U85 Resistance to antineoplastic drugs
0.668 0.332 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.668 0.332 0.000
N11 Chronic tubulo-interstitial nephritis
0.667 0.333 0.000
I78 Diseases of capillaries
0.667 0.333 0.000
Q90-Q99 Chromosomal abnormalities, not elsewhere classified
0.667 0.333 0.000
Q35-Q37 Cleft lip and cleft palate
0.667 0.333 0.000
Q30-Q34 Congenital malformations of the respiratory system
0.667 0.333 0.000
Q10-Q18 Congenital malformations of eye, ear, face and neck
0.667 0.333 0.000
G47.0 Disorders of initiating and maintaining sleep [insomnias]
0.667 0.333 0.000
C26 Malignant neoplasm of other and ill-defined digestive organs
0.667 0.333 0.000
N13.4 Hydroureter
0.666 0.334 0.000
E23.2 Diabetes insipidus
0.666 0.334 0.000
E24 Cushing's syndrome
0.666 0.334 0.000
M19.04 Primary arthrosis of other joints (Hand)
0.666 0.334 0.000
Y00-Y09 Assault
0.664 0.335 0.000
K82.1 Hydrops of gallbladder
0.664 0.335 0.000
G47.9 Sleep disorder, unspecified
0.664 0.336 0.000
K35-K38 Diseases of appendix
0.664 0.336 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.663 0.337 0.000
E80 Disorders of porphyrin and bilirubin metabolism
0.663 0.337 0.000
M19.08 Primary arthrosis of other joints (Other)
0.663 0.337 0.000
M19.06 Primary arthrosis of other joints-Lower leg
0.663 0.337 0.000
M19.05 Primary arthrosis of other joints (Pelvic region and thigh)
0.663 0.337 0.000
M19.03 Primary arthrosis of other joints (Forearm)
0.663 0.337 0.000
M19.02 Primary arthrosis of other joints (Upper arm)
0.663 0.337 0.000
M19.00 Primary arthrosis of other joints (Multiple sites)
0.663 0.337 0.000
W20-W49 Exposure to inanimate mechanical forces
0.662 0.338 0.000
Q24 Other congenital malformations of heart
0.661 0.339 0.000
T98 Sequelae of other and unspecified effects of external causes
0.661 0.339 0.000
T95 Sequelae of burns, corrosions and frostbite
0.661 0.339 0.000
T94 Sequelae of injuries involving multiple and unspecified body regions
0.661 0.339 0.000
T97 Sequelae of toxic effects of substances chiefly nonmedicinal as to source
0.661 0.339 0.000
T96 Sequelae of poisoning by drugs, medicaments and biological substances
0.661 0.339 0.000
S90-S99 Injuries to the ankle and foot
0.661 0.339 0.000
I70 Atherosclerosis
0.661 0.339 0.000
I44.0 Atrioventricular block, first degree
0.661 0.339 0.000
X62 Intentional self-poisoning by and exposure to narcotics and psychodysleptics [hallucinogens], not elsewhere classified
0.660 0.340 0.000
M30.1 Polyarteritis with lung involvement [Churg-Strauss]
0.660 0.340 0.000
K05.6 Periodontal disease, unspecified
0.660 0.340 0.000
I05.0 Mitral stenosis
0.660 0.340 0.000
T91.1 Sequelae of fracture of spine
0.659 0.341 0.000
N29 Other disorders of kidney and ureter in diseases classified elsewhere
0.658 0.342 0.000
N27 Small kidney of unknown cause
0.658 0.342 0.000
K82.3 Fistula of gallbladder
0.658 0.342 0.000
K82.2 Perforation of gallbladder
0.658 0.342 0.000
K82.0 Obstruction of gallbladder
0.658 0.342 0.000
C45-C49 Malignant neoplasms of mesothelial and soft tissue
0.658 0.342 0.000
C02 Malignant neoplasm of other and unspecified parts of tongue
0.658 0.342 0.000
N26 Unspecified contracted kidney
0.658 0.342 0.000
K10 Other diseases of jaws
0.658 0.342 0.000
M21 Other acquired deformities of limbs
0.657 0.342 0.000
M25.66 Stiffness of joint, not elsewhere classified (Lower leg)
0.657 0.342 0.000
I05.8 Other mitral valve diseases
0.657 0.343 0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.656 0.344 0.000
D68 Other coagulation defects
0.656 0.344 0.000
E87.4 Mixed disorder of acid-base balance
0.655 0.345 0.000
M88 Paget's disease of bone [osteitis deformans]
0.655 0.345 0.000
T68 Hypothermia
0.655 0.345 0.000
G63 Polyneuropathy in diseases classified elsewhere
0.654 0.346 0.000
K81.0 Acute cholecystitis
0.654 0.346 0.000
Q85 Phakomatoses, not elsewhere classified
0.654 0.346 0.000
E88 Other metabolic disorders
0.653 0.346 0.000
M87 Osteonecrosis
0.653 0.347 0.000
S83 Dislocation, sprain and strain of joints and ligaments of knee
0.651 0.349 0.000
K04.6 Periapical abscess with sinus
0.651 0.349 0.000
S69 Other and unspecified injuries of wrist and hand
0.650 0.350 0.000
M72 Fibroblastic disorders
0.650 0.350 0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use
0.650 0.350 0.000
A50-A64 Infections with a predominantly sexual mode of transmission
0.650 0.350 0.000
M24.8 Other specific joint derangements, not elsewhere classified
0.650 0.350 0.000
M19.13 Post-traumatic arthrosis of other joints (Forearm)
0.649 0.350 0.000
G58.8 Other specified mononeuropathies
0.649 0.351 0.000
M15.1 Heberden's nodes (with arthropathy)
0.649 0.351 0.000
I31.3 Pericardial effusion (noninflammatory)
0.649 0.351 0.000
G52 Disorders of other cranial nerves
0.649 0.351 0.000
B08 Other viral infections characterised by skin and mucous membrane lesions, not elsewhere classified
0.648 0.352 0.000
B06 Rubella [German measles]
0.648 0.352 0.000
B05 Measles
0.648 0.352 0.000
B01 Varicella [chickenpox]
0.648 0.352 0.000
B09 Unspecified viral infection characterised by skin and mucous membrane lesions
0.648 0.352 0.000
B04 Monkeypox
0.648 0.352 0.000
B03 Smallpox
0.648 0.352 0.000
C73-C75 Malignant neoplasms of thyroid and other endocrine glands
0.648 0.352 0.000
G24 Dystonia
0.647 0.352 0.000
G23 Other degenerative diseases of basal ganglia
0.647 0.352 0.000
G21 Secondary Parkinsonism
0.647 0.352 0.000
G26 Extrapyramidal and movement disorders in diseases classified elsewhere
0.647 0.352 0.000
G22 Parkinsonism in diseases classified elsewhere
0.647 0.352 0.000
E22 Hyperfunction of pituitary gland
0.646 0.354 0.000
A49.0 Staphylococcal infection, unspecified
0.646 0.354 0.000
G62.8 Other specified polyneuropathies
0.646 0.354 0.000
I74.3 Embolism and thrombosis of arteries of the lower extremities
0.645 0.355 0.000
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.645 0.355 0.000
E27 Other disorders of adrenal gland
0.645 0.355 0.000
K05.3 Chronic periodontitis
0.645 0.355 0.000
S10 Superficial injury of neck
0.643 0.356 0.000
M15.2 Bouchard's nodes (with arthropathy)
0.643 0.357 0.000
K86.9 Disease of pancreas, unspecified
0.643 0.357 0.000
E23.6 Other disorders of pituitary gland
0.643 0.357 0.000
A40.9 Streptococcal septicaemia, unspecified
0.643 0.357 0.000
Y35-Y36 Legal intervention and operations of war
0.643 0.357 0.000
Y10-Y34 Event of undetermined intent
0.643 0.357 0.000
X85-X99 Assault
0.643 0.357 0.000
X58-X59 Accidental exposure to other and unspecified factors
0.643 0.357 0.000
X30-X39 Exposure to forces of nature
0.643 0.357 0.000
X20-X29 Contact with venomous animals and plants
0.643 0.357 0.000
X10-X19 Contact with heat and hot substances
0.643 0.357 0.000
X00-X09 Exposure to smoke, fire and flames
0.643 0.357 0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure
0.643 0.357 0.000
W75-W84 Other accidental threats to breathing
0.643 0.357 0.000
W65-W74 Accidental drowning and submersion
0.643 0.357 0.000
W50-W64 Exposure to animate mechanical forces
0.643 0.357 0.000
V98-V99 Other and unspecified transport accidents
0.643 0.357 0.000
V95-V97 Air and space transport accidents
0.643 0.357 0.000
V90-V94 Water transport accidents
0.643 0.357 0.000
V70-V79 Bus occupant injured in transport accident
0.643 0.357 0.000
V60-V69 Occupant of heavy transport vehicle injured in transport accident
0.643 0.357 0.000
V50-V59 Occupant of pick-up truck or van injured in transport accident
0.643 0.357 0.000
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident
0.643 0.357 0.000
V01-V09 Pedestrian injured in transport accident
0.643 0.357 0.000
K09 Cysts of oral region, not elsewhere classified
0.643 0.357 0.000
C50 Malignant neoplasm of breast
0.642 0.358 0.000
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.642 0.358 0.000
S68 Traumatic amputation of wrist and hand
0.642 0.358 0.000
K67 Disorders of peritoneum in infectious diseases classified elsewhere
0.642 0.358 0.000
C25 Malignant neoplasm of pancreas
0.641 0.359 0.000
C21 Malignant neoplasm of anus and anal canal
0.641 0.359 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.640 0.359 0.000
I77.1 Stricture of artery
0.639 0.361 0.000
Q38-Q45 Other congenital malformations of the digestive system
0.638 0.362 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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