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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2071349
log Bayes Factor = 12.0527
Chromosome 6   position 33,043,520  (GRCh37) Explore rs2071349 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
1.000 0.000 0.000
K90.0 Coeliac disease
0.000 0.000 1.000
N47 Redundant prepuce, phimosis and paraphimosis
0.000 0.001 0.999
N48 Other disorders of penis
0.000 0.010 0.990
N48.6 Balanitis xerotica obliterans
0.000 0.011 0.989
N40-N51 Diseases of male genital organs
0.000 0.012 0.988
E03 Other hypothyroidism
0.976 0.024 0.000
E10 Insulin-dependent diabetes mellitus
0.961 0.039 0.000
E10-E14 Diabetes mellitus
0.950 0.050 0.000
E00-E07 Disorders of thyroid gland
0.947 0.053 0.000
E10.4 With neurological complications
0.944 0.056 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.943 0.057 0.000
N41 Inflammatory diseases of prostate
0.000 0.096 0.904
N48.9 Disorder of penis, unspecified
0.000 0.098 0.902
E10.1 With ketoacidosis
0.895 0.105 0.000
N48.2 Other inflammatory disorders of penis
0.000 0.130 0.870
E14 Unspecified diabetes mellitus
0.866 0.134 0.000
E10.2 With renal complications
0.861 0.139 0.000
N41.9 Inflammatory disease of prostate, unspecified
0.000 0.145 0.855
N48.0 Leukoplakia of penis
0.000 0.147 0.853
E10.9 Without complications
0.849 0.151 0.000
E10.3 With ophthalmic complications
0.847 0.153 0.000
E03.8 Other specified hypothyroidism
0.830 0.170 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.827 0.173 0.000
N50 Other disorders of male genital organs
0.000 0.190 0.810
E10.0 With coma
0.807 0.193 0.000
N41.0 Acute prostatitis
0.000 0.210 0.790
N48.1 Balanoposthitis
0.000 0.227 0.773
E06 Thyroiditis
0.767 0.233 0.000
N50.8 Other specified disorders of male genital organs
0.000 0.235 0.765
N48.5 Ulcer of penis
0.000 0.241 0.759
E16 Other disorders of pancreatic internal secretion
0.745 0.255 0.000
E50-E64 Other nutritional deficiencies
0.742 0.258 0.000
E10.5 With peripheral circulatory complications
0.725 0.275 0.000
E14.3 With ophthalmic complications
0.717 0.283 0.000
E14.1 With ketoacidosis
0.716 0.284 0.000
N51 Disorders of male genital organs in diseases classified elsewhere
0.000 0.291 0.708
N44 Torsion of testis
0.000 0.291 0.708
E10.6 With other specified complications
0.705 0.294 0.000
E03.5 Myxoedema coma
0.700 0.300 0.000
E03.4 Atrophy of thyroid (acquired)
0.700 0.300 0.000
E03.3 Postinfectious hypothyroidism
0.700 0.300 0.000
E03.1 Congenital hypothyroidism without goitre
0.700 0.300 0.000
E03.0 Congenital hypothyroidism with diffuse goitre
0.700 0.300 0.000
E10.7 With multiple complications
0.689 0.311 0.000
E20-E35 Disorders of other endocrine glands
0.685 0.315 0.000
E12 Malnutrition-related diabetes mellitus
0.681 0.319 0.000
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.680 0.319 0.000
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.679 0.321 0.000
E00 Congenital iodine-deficiency syndrome
0.679 0.321 0.000
E02 Subclinical iodine-deficiency hypothyroidism
0.679 0.321 0.000
E14.6 With other specified complications
0.664 0.336 0.000
E16.2 Hypoglycaemia, unspecified
0.663 0.337 0.000
E10.8 With unspecified complications
0.661 0.338 0.000
E14.4 With neurological complications
0.658 0.342 0.000
E07 Other disorders of thyroid
0.657 0.343 0.000
N48.3 Priapism
0.000 0.349 0.650
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.650 0.350 0.000
E06.3 Autoimmune thyroiditis
0.649 0.351 0.000
N41.8 Other inflammatory diseases of prostate
0.000 0.351 0.648
N41.3 Prostatocystitis
0.000 0.351 0.648
N41.2 Abscess of prostate
0.000 0.351 0.648
N45 Orchitis and epididymitis
0.000 0.355 0.645
E13 Other specified diabetes mellitus
0.639 0.361 0.000
E14.9 Without complications
0.633 0.367 0.000
E55 Vitamin D deficiency
0.629 0.371 0.000
E14.7 With multiple complications
0.621 0.379 0.000
E14.5 With peripheral circulatory complications
0.621 0.379 0.000
E14.2 Withrenal complications
0.621 0.379 0.000
E14.0 With coma
0.621 0.379 0.000
E14.8 With unspecified complications
0.618 0.382 0.000
N50.0 Atrophy of testis
0.000 0.383 0.617
N43 Hydrocele and spermatocele
0.000 0.389 0.611
N48.4 Impotence of organic origin
0.000 0.403 0.597
E21.3 Hyperparathyroidism, unspecified
0.594 0.406 0.000
E15 Nondiabetic hypoglycaemic coma
0.593 0.407 0.000
E16.0 Drug-induced hypoglycaemia without coma
0.592 0.408 0.000
N49 Inflammatory disorders of male genital organs, not elsewhere classified
0.000 0.410 0.590
E58 Dietary calcium deficiency
0.590 0.410 0.000
N46 Male infertility
0.000 0.439 0.561
E61 Deficiency of other nutrient elements
0.557 0.443 0.000
E20 Hypoparathyroidism
0.555 0.445 0.000
E06.5 Other chronic thyroiditis
0.550 0.450 0.000
E06.4 Drug-induced thyroiditis
0.550 0.450 0.000
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.550 0.450 0.000
E06.1 Subacute thyroiditis
0.550 0.450 0.000
E06.0 Acute thyroiditis
0.550 0.450 0.000
E55.9 Vitamin D deficiency, unspecified
0.548 0.452 0.000
E21.0 Primary hyperparathyroidism
0.546 0.454 0.000
E65-E68 Obesity and other hyperalimentation
0.538 0.462 0.000
E16.9 Disorder of pancreatic internal secretion, unspecified
0.534 0.466 0.000
E16.8 Other specified disorders of pancreatic internal secretion
0.534 0.466 0.000
E16.4 Abnormal secretion of gastrin
0.534 0.466 0.000
E16.3 Increased secretion of glucagon
0.534 0.466 0.000
E16.1 Other hypoglycaemia
0.534 0.466 0.000
E64 Sequelae of malnutrition and other nutritional deficiencies
0.532 0.468 0.000
E63 Other nutritional deficiencies
0.532 0.468 0.000
E56 Other vitamin deficiencies
0.532 0.468 0.000
E51 Thiamine deficiency
0.532 0.468 0.000
E50 Vitamin A deficiency
0.532 0.468 0.000
E60 Dietary zinc deficiency
0.532 0.468 0.000
E59 Dietary selenium deficiency
0.532 0.468 0.000
E54 Ascorbic acid deficiency
0.532 0.468 0.000
E52 Niacin deficiency [pellagra]
0.532 0.468 0.000
E06.9 Thyroiditis, unspecified
0.530 0.469 0.000
E23 Hypofunction and other disorders of pituitary gland
0.528 0.472 0.000
E24 Cushing's syndrome
0.524 0.476 0.000
N50.9 Disorder of male genital organs, unspecified
0.000 0.484 0.516
E26 Hyperaldosteronism
0.516 0.484 0.000
N51.8 Other disorders of male genital organs in diseases classified elsewhere
0.000 0.492 0.508
N51.2 Balanitis in diseases classified elsewhere
0.000 0.492 0.508
N51.1 Disorders of testis and epididymis in diseases classified elsewhere
0.000 0.492 0.508
N51.0 Disorders of prostate in diseases classified elsewhere
0.000 0.492 0.508
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.503 0.496 0.000
E35 Disorders of endocrine glands in diseases classified elsewhere
0.491 0.509 0.000
E32 Diseases of thymus
0.491 0.509 0.000
E31 Polyglandular dysfunction
0.491 0.509 0.000
E30 Disorders of puberty, not elsewhere classified
0.491 0.509 0.000
E25 Adrenogenital disorders
0.491 0.509 0.000
E07.8 Other specified disorders of thyroid
0.490 0.510 0.000
E12.9 Without complications
0.488 0.511 0.000
E12.8 With unspecified complications
0.488 0.511 0.000
E12.7 With multiple complications
0.488 0.511 0.000
E12.6 With other specified complications
0.488 0.511 0.000
E12.5 With peripheral circulatory complications
0.488 0.511 0.000
E12.4 With neurological complications
0.488 0.511 0.000
E12.3 With ophthalmic complications
0.488 0.511 0.000
E12.2 With renal complications
0.488 0.511 0.000
E12.1 With ketoacidosis
0.488 0.511 0.000
E12.0 With coma
0.488 0.511 0.000
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.487 0.513 0.000
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.487 0.513 0.000
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.487 0.513 0.000
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.487 0.513 0.000
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.487 0.513 0.000
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.487 0.513 0.000
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.487 0.513 0.000
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.487 0.513 0.000
E07.1 Dyshormogenetic goitre
0.471 0.529 0.000
E07.0 Hypersecretion of calcitonin
0.471 0.529 0.000
E21.5 Disorder of parathyroid gland, unspecified
0.466 0.534 0.000
E21.4 Other specified disorders of parathyroid gland
0.466 0.534 0.000
E21.2 Other hyperparathyroidism
0.466 0.534 0.000
E40-E46 Malnutrition
0.461 0.537 0.001
N45.0 Orchitis, epididymitis and epididymo-orchitis with abscess
0.000 0.537 0.462
E20.9 Hypoparathyroidism, unspecified
0.461 0.538 0.000
E13.8 With unspecified complications
0.458 0.542 0.000
E13.7 With multiple complications
0.458 0.542 0.000
E13.6 With other specified complications
0.458 0.542 0.000
E13.5 With peripheral circulatory complications
0.458 0.542 0.000
E13.4 With neurological complications
0.458 0.542 0.000
E13.3 With ophthalmic complications
0.458 0.542 0.000
E13.2 With renal complications
0.458 0.542 0.000
E13.1 With ketoacidosis
0.458 0.542 0.000
E13.0 With coma
0.458 0.542 0.000
E55.0 Rickets, active
0.451 0.549 0.000
E23.7 Disorder of pituitary gland, unspecified
0.449 0.551 0.000
K90 Intestinal malabsorption
0.000 0.558 0.442
N43.2 Other hydrocele
0.000 0.562 0.438
N43.1 Infected hydrocele
0.000 0.562 0.438
N43.0 Encysted hydrocele
0.000 0.562 0.438
E34 Other endocrine disorders
0.435 0.565 0.000
E07.9 Disorder of thyroid, unspecified
0.424 0.576 0.000
E61.1 Iron deficiency
0.424 0.576 0.000
N49.9 Inflammatory disorder of unspecified male genital organ
0.000 0.577 0.423
N49.8 Inflammatory disorders of other specified male genital organs
0.000 0.577 0.423
N49.1 Inflammatory disorders of spermatic cord, tunica vaginalis and vas deferens
0.000 0.577 0.423
N49.0 Inflammatory disorders of seminal vesicle
0.000 0.577 0.423
E13.9 Without complications
0.415 0.584 0.000
E05 Thyrotoxicosis [hyperthyroidism]
0.412 0.588 0.000
N43.4 Spermatocele
0.000 0.591 0.409
E23.6 Other disorders of pituitary gland
0.407 0.593 0.000
E65 Localised adiposity
0.406 0.593 0.000
E61.9 Deficiency of nutrient element, unspecified
0.399 0.601 0.000
E61.8 Deficiency of other specified nutrient elements
0.399 0.601 0.000
E61.7 Deficiency of multiple nutrient elements
0.399 0.601 0.000
E61.6 Vanadium deficiency
0.399 0.601 0.000
E61.5 Molybdenum deficiency
0.399 0.601 0.000
E61.4 Chromium deficiency
0.399 0.601 0.000
E61.3 Manganese deficiency
0.399 0.601 0.000
E61.2 Magnesium deficiency
0.399 0.601 0.000
E61.0 Copper deficiency
0.399 0.601 0.000
N45.9 Orchitis, epididymitis and epididymo-orchitis without abscess
0.000 0.601 0.399
E22 Hyperfunction of pituitary gland
0.398 0.602 0.000
E20.8 Other hypoparathyroidism
0.398 0.602 0.000
E20.1 Pseudohypoparathyroidism
0.398 0.602 0.000
E20.0 Idiopathic hypoparathyroidism
0.398 0.602 0.000
E26.0 Primary hyperaldosteronism
0.394 0.605 0.000
E24.0 Pituitary-dependent Cushing's disease
0.393 0.606 0.000
E24.9 Cushing's syndrome, unspecified
0.393 0.606 0.000
E67 Other hyperalimentation
0.386 0.614 0.000
E68 Sequelae of hyperalimentation
0.386 0.614 0.000
E50.9 Vitamin A deficiency, unspecified
0.382 0.618 0.000
E50.8 Other manifestations of vitamin A deficiency
0.382 0.618 0.000
E50.7 Other ocular manifestations of vitamin A deficiency
0.382 0.618 0.000
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.382 0.618 0.000
E50.5 Vitamin A deficiency with night blindness
0.382 0.618 0.000
E50.4 Vitamin A deficiency with keratomalacia
0.382 0.618 0.000
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.382 0.618 0.000
E50.2 Vitamin A deficiency with corneal xerosis
0.382 0.618 0.000
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.382 0.618 0.000
E50.0 Vitamin A deficiency with conjunctival xerosis
0.382 0.618 0.000
E51.9 Thiamine deficiency, unspecified
0.382 0.618 0.000
E51.8 Other manifestations of thiamine deficiency
0.382 0.618 0.000
E51.2 Wernicke's encephalopathy
0.382 0.618 0.000
E51.1 Beriberi
0.382 0.618 0.000
E56.9 Vitamin deficiency, unspecified
0.382 0.618 0.000
E56.8 Deficiency of other vitamins
0.382 0.618 0.000
E56.1 Deficiency of vitamin K
0.382 0.618 0.000
E56.0 Deficiency of vitamin E
0.382 0.618 0.000
E63.9 Nutritional deficiency, unspecified
0.382 0.618 0.000
E63.8 Other specified nutritional deficiencies
0.382 0.618 0.000
E63.1 Imbalance of constituents of food intake
0.382 0.618 0.000
E63.0 Essential fatty acid [EFA] deficiency
0.382 0.618 0.000
E64.9 Sequelae of unspecified nutritional deficiency
0.382 0.618 0.000
E64.8 Sequelae of other nutritional deficiencies
0.382 0.618 0.000
E64.3 Sequelae of rickets
0.382 0.618 0.000
E64.2 Sequelae of vitamin C deficiency
0.382 0.618 0.000
E64.1 Sequelae of vitamin A deficiency
0.382 0.618 0.000
E64.0 Sequelae of protein-energy malnutrition
0.382 0.618 0.000
N43.3 Hydrocele, unspecified
0.000 0.620 0.380
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.379 0.621 0.000
E23.1 Drug-induced hypopituitarism
0.379 0.621 0.000
E29 Testicular dysfunction
0.378 0.622 0.000
N48.8 Other specified disorders of penis
0.000 0.623 0.377
E24.8 Other Cushing's syndrome
0.376 0.624 0.000
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.376 0.624 0.000
E24.3 Ectopic ACTH syndrome
0.376 0.624 0.000
E24.2 Drug-induced Cushing's syndrome
0.376 0.624 0.000
E24.1 Nelson's syndrome
0.376 0.624 0.000
E26.9 Hyperaldosteronism, unspecified
0.370 0.630 0.000
E26.8 Other hyperaldosteronism
0.370 0.630 0.000
E26.1 Secondary hyperaldosteronism
0.370 0.630 0.000
E25.9 Adrenogenital disorder, unspecified
0.352 0.648 0.000
E25.8 Other adrenogenital disorders
0.352 0.648 0.000
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.352 0.648 0.000
E30.9 Disorder of puberty, unspecified
0.352 0.648 0.000
E30.8 Other disorders of puberty
0.352 0.648 0.000
E30.1 Precocious puberty
0.352 0.648 0.000
E30.0 Delayed puberty
0.352 0.648 0.000
E31.9 Polyglandular dysfunction, unspecified
0.352 0.648 0.000
E31.8 Other polyglandular dysfunction
0.352 0.648 0.000
E31.1 Polyglandular hyperfunction
0.352 0.648 0.000
E31.0 Autoimmune polyglandular failure
0.352 0.648 0.000
E32.9 Disease of thymus, unspecified
0.352 0.648 0.000
E32.8 Other diseases of thymus
0.352 0.648 0.000
E32.1 Abscess of thymus
0.352 0.648 0.000
E32.0 Persistent hyperplasia of thymus
0.352 0.648 0.000
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.352 0.648 0.000
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.352 0.648 0.000
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.352 0.648 0.000
E23.2 Diabetes insipidus
0.340 0.660 0.000
E44 Protein-energy malnutrition of moderate and mild degree
0.331 0.668 0.001
E45 Retarded development following protein-energy malnutrition
0.331 0.668 0.001
E43 Unspecified severe protein-energy malnutrition
0.331 0.668 0.001
E42 Marasmic kwashiorkor
0.331 0.668 0.001
E41 Nutritional marasmus
0.331 0.668 0.001
E40 Kwashiorkor
0.331 0.668 0.001
K90.9 Intestinal malabsorption, unspecified
0.000 0.669 0.331
E53 Deficiency of other B group vitamins
0.327 0.673 0.000
E23.0 Hypopituitarism
0.322 0.678 0.000
K90.3 Pancreatic steatorrhoea
0.000 0.683 0.317
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.683 0.317
K90.1 Tropical sprue
0.000 0.683 0.317
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.687 0.313
E34.5 Androgen resistance syndrome
0.312 0.688 0.000
E34.4 Constitutional tall stature
0.312 0.688 0.000
E34.3 Short stature, not elsewhere classified
0.312 0.688 0.000
E34.2 Ectopic hormone secretion, not elsewhere classified
0.312 0.688 0.000
E34.1 Other hypersecretion of intestinal hormones
0.312 0.688 0.000
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.311 0.689 0.000
K90.8 Other intestinal malabsorption
0.000 0.691 0.309
E34.0 Carcinoid syndrome
0.305 0.695 0.000
N49.2 Inflammatory disorders of scrotum
0.000 0.695 0.305
E28 Ovarian dysfunction
0.304 0.695 0.001
E34.9 Endocrine disorder, unspecified
0.299 0.701 0.000
E05.5 Thyroid crisis or storm
0.296 0.704 0.000
E05.4 Thyrotoxicosis factitia
0.296 0.704 0.000
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.296 0.704 0.000
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.296 0.704 0.000
E22.9 Hyperfunction of pituitary gland, unspecified
0.285 0.714 0.000
E22.8 Other hyperfunction of pituitary gland
0.285 0.714 0.000
E05.0 Thyrotoxicosis with diffuse goitre
0.284 0.716 0.000
E05.8 Other thyrotoxicosis
0.283 0.717 0.000
E34.8 Other specified endocrine disorders
0.281 0.719 0.000
E67.8 Other specified hyperalimentation
0.277 0.723 0.000
E67.3 Hypervitaminosis D
0.277 0.723 0.000
E67.2 Megavitamin-B6 syndrome
0.277 0.723 0.000
E67.1 Hypercarotenaemia
0.277 0.723 0.000
E67.0 Hypervitaminosis A
0.277 0.723 0.000
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.276 0.724 0.000
E29.9 Testicular dysfunction, unspecified
0.271 0.729 0.000
E29.8 Other testicular dysfunction
0.271 0.729 0.000
E29.0 Testicular hyperfunction
0.271 0.729 0.000
E27 Other disorders of adrenal gland
0.254 0.746 0.001
E22.1 Hyperprolactinaemia
0.254 0.746 0.000
E44.1 Mild protein-energy malnutrition
0.237 0.762 0.001
E44.0 Moderate protein-energy malnutrition
0.237 0.762 0.001
N42 Other disorders of prostate
0.000 0.763 0.237
E53.1 Pyridoxine deficiency
0.234 0.765 0.000
E53.0 Riboflavin deficiency
0.234 0.765 0.000
E53.9 Vitamin B deficiency, unspecified
0.228 0.771 0.000
E28.9 Ovarian dysfunction, unspecified
0.218 0.781 0.001
E28.8 Other ovarian dysfunction
0.218 0.781 0.001
E28.1 Androgen excess
0.218 0.781 0.001
E28.0 Oestrogen excess
0.218 0.781 0.001
N41.1 Chronic prostatitis
0.000 0.785 0.215
E11 Non-insulin-dependent diabetes mellitus
0.203 0.797 0.000
E66 Obesity
0.202 0.798 0.000
N50.1 Vascular disorders of male genital organs
0.000 0.798 0.201
E27.4 Other and unspecified adrenocortical insufficiency
0.191 0.809 0.000
E22.0 Acromegaly and pituitary gigantism
0.190 0.810 0.001
N42.2 Atrophy of prostate
0.000 0.815 0.185
E11.1 With ketoacidosis
0.184 0.816 0.000
E27.5 Adrenomedullary hyperfunction
0.182 0.817 0.001
E27.3 Drug-induced adrenocortical insufficiency
0.182 0.817 0.001
E27.0 Other adrenocortical overactivity
0.182 0.817 0.001
E28.3 Primary ovarian failure
0.181 0.818 0.001
E27.2 Addisonian crisis
0.178 0.822 0.000
N42.3 Dysplasia of prostate
0.000 0.830 0.170
N42.0 Calculus of prostate
0.000 0.832 0.167
E11.2 With renal complications
0.166 0.834 0.000
E27.8 Other specified disorders of adrenal gland
0.160 0.839 0.001
E11.0 With coma
0.158 0.842 0.000
E29.1 Testicular hypofunction
0.157 0.842 0.001
E27.9 Disorder of adrenal gland, unspecified
0.154 0.846 0.001
E11.7 With multiple complications
0.145 0.854 0.000
E66.0 Obesity due to excess calories
0.145 0.854 0.000
E66.1 Drug-induced obesity
0.145 0.855 0.000
E66.2 Extreme obesity with alveolar hypoventilation
0.144 0.856 0.000
E05.9 Thyrotoxicosis, unspecified
0.143 0.857 0.000
E04 Other non-toxic goitre
0.142 0.858 0.000
E70-E90 Metabolic disorders
0.137 0.863 0.000
E85 Amyloidosis
0.131 0.869 0.000
E66.8 Other obesity
0.130 0.870 0.000
E11.6 With other specified complications
0.130 0.870 0.000
E11.8 With unspecified complications
0.124 0.875 0.000
N42.1 Congestion and haemorrhage of prostate
0.000 0.879 0.121
E46 Unspecified protein-energy malnutrition
0.117 0.881 0.003
E85.9 Amyloidosis, unspecified
0.116 0.884 0.000
E85.3 Secondary systemic amyloidosis
0.115 0.885 0.000
E88 Other metabolic disorders
0.115 0.885 0.000
E28.2 Polycystic ovarian syndrome
0.114 0.885 0.001
E11.5 With peripheral circulatory complications
0.111 0.889 0.000
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.109 0.891 0.000
L90.0 Lichen sclerosus et atrophicus
0.000 0.892 0.108
E85.4 Organ-limited amyloidosis
0.102 0.898 0.000
N42.9 Disorder of prostate, unspecified
0.000 0.898 0.102
E04.8 Other specified non-toxic goitre
0.102 0.898 0.000
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.100 0.900 0.000
E84 Cystic fibrosis
0.099 0.901 0.000
E79 Disorders of purine and pyrimidine metabolism
0.099 0.901 0.000
E77 Disorders of glycoprotein metabolism
0.099 0.901 0.000
E76 Disorders of glycosaminoglycan metabolism
0.099 0.901 0.000
E72 Other disorders of amino-acid metabolism
0.099 0.901 0.000
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.099 0.901 0.000
E70 Disorders of aromatic amino-acid metabolism
0.099 0.901 0.000
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.099 0.901 0.000
E04.0 Non-toxic diffuse goitre
0.098 0.902 0.000
E85.8 Other amyloidosis
0.094 0.906 0.000
E85.2 Heredofamilial amyloidosis, unspecified
0.094 0.906 0.000
E85.1 Neuropathic heredofamilial amyloidosis
0.094 0.906 0.000
E85.0 Nonneuropathic heredofamilial amyloidosis
0.094 0.906 0.000
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.094 0.906 0.000
E73 Lactose intolerance
0.093 0.907 0.000
E80 Disorders of porphyrin and bilirubin metabolism
0.091 0.909 0.000
E74 Other disorders of carbohydrate metabolism
0.089 0.910 0.000
E75.2 Other sphingolipidosis
0.089 0.911 0.000
E88.9 Metabolic disorder, unspecified
0.082 0.917 0.000
E88.8 Other specified metabolic disorders
0.082 0.917 0.000
E88.3 Tumour lysis syndrome
0.082 0.917 0.000
E88.1 Lipodystrophy, not elsewhere classified
0.082 0.917 0.000
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.080 0.920 0.000
E88.2 Lipomatosis, not elsewhere classified
0.080 0.920 0.000
E75.6 Lipid storage disorder, unspecified
0.078 0.922 0.000
E75.5 Other lipid storage disorders
0.078 0.922 0.000
E75.4 Neuronal ceroid lipofuscinosis
0.078 0.922 0.000
E75.3 Sphingolipidosis, unspecified
0.078 0.922 0.000
E75.1 Other gangliosidosis
0.078 0.922 0.000
E75.0 GM2 gangliosidosis
0.078 0.922 0.000
D41.4 Bladder
0.073 0.927 0.000
E27.1 Primary adrenocortical insufficiency
0.072 0.927 0.001
L90 Atrophic disorders of skin
0.000 0.928 0.072
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.071 0.929 0.000
E70.8 Other disorders of aromatic amino-acid metabolism
0.071 0.929 0.000
E70.3 Albinism
0.071 0.929 0.000
E70.2 Disorders of tyrosine metabolism
0.071 0.929 0.000
E70.1 Other hyperphenylalaninaemias
0.071 0.929 0.000
E70.0 Classical phenylketonuria
0.071 0.929 0.000
E71.3 Disorders of fatty-acid metabolism
0.071 0.929 0.000
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.071 0.929 0.000
E71.1 Other disorders of branched-chain amino-acid metabolism
0.071 0.929 0.000
E71.0 Maple-syrup-urine disease
0.071 0.929 0.000
E72.9 Disorder of amino-acid metabolism, unspecified
0.071 0.929 0.000
E72.8 Other specified disorders of amino-acid metabolism
0.071 0.929 0.000
E72.5 Disorders of glycine metabolism
0.071 0.929 0.000
E72.4 Disorders of ornithine metabolism
0.071 0.929 0.000
E72.3 Disorders of lysine and hydroxylysine metabolism
0.071 0.929 0.000
E72.2 Disorders of urea cycle metabolism
0.071 0.929 0.000
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.071 0.929 0.000
E72.0 Disorders of amino-acid transport
0.071 0.929 0.000
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.071 0.929 0.000
E76.8 Other disorders of glucosaminoglycan metabolism
0.071 0.929 0.000
E76.3 Mucopolysaccharidosis, unspecified
0.071 0.929 0.000
E76.2 Other mucopolysaccharidoses
0.071 0.929 0.000
E76.1 Mucopolysaccharidosis, type II
0.071 0.929 0.000
E76.0 Mucopolysaccharidosis, type I
0.071 0.929 0.000
E77.9 Disorder of glycoprotein metabolism, unspecified
0.071 0.929 0.000
E77.8 Other disorders of glycoprotein metabolism
0.071 0.929 0.000
E77.1 Defects in glycoprotein degradation
0.071 0.929 0.000
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.071 0.929 0.000
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.071 0.929 0.000
E79.8 Other disorders of purine and pyrimidine metabolism
0.071 0.929 0.000
E79.1 Lesch-Nyhan syndrome
0.071 0.929 0.000
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.071 0.929 0.000
E84.9 Cystic fibrosis, unspecified
0.071 0.929 0.000
E84.8 Cystic fibrosis with other manifestations
0.071 0.929 0.000
E84.1 Cystic fibrosis with intestinal manifestations
0.071 0.929 0.000
E84.0 Cystic fibrosis with pulmonary manifestations
0.071 0.929 0.000
E89.4 Postprocedural ovarian failure
0.070 0.930 0.000
E04.2 Non-toxic multinodular goitre
0.067 0.932 0.000
E89.2 Postprocedural hypoparathyroidism
0.067 0.933 0.000
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.067 0.933 0.000
E89.8 Other postprocedural endocrine and metabolic disorders
0.067 0.933 0.000
E89.5 Postprocedural testicular hypofunction
0.067 0.933 0.000
E89.1 Postprocedural hypoinsulinaemia
0.067 0.933 0.000
E73.8 Other lactose intolerance
0.067 0.933 0.000
E73.1 Secondary lactase deficiency
0.067 0.933 0.000
E73.0 Congenital lactase deficiency
0.067 0.933 0.000
E80.7 Disorder of bilirubin metabolism, unspecified
0.065 0.935 0.000
E80.6 Other disorders of bilirubin metabolism
0.065 0.935 0.000
E80.5 Crigler-Najjar syndrome
0.065 0.935 0.000
E80.3 Defects of catalase and peroxydase
0.065 0.935 0.000
E80.2 Other porphyria
0.065 0.935 0.000
E80.1 Porphyria cutanea tarda
0.065 0.935 0.000
E80.0 Hereditary erythropoietic porphyria
0.065 0.935 0.000
D41 Neoplasm of uncertain or unknown behaviour of urinary organs
0.065 0.935 0.000
E74.9 Disorder of carbohydrate metabolism, unspecified
0.064 0.936 0.000
E74.8 Other specified disorders of carbohydrate metabolism
0.064 0.936 0.000
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.064 0.936 0.000
E74.2 Disorders of galactose metabolism
0.064 0.936 0.000
E74.1 Disorders of fructose metabolism
0.064 0.936 0.000
E74.0 Glycogen storage disease
0.064 0.936 0.000
L90.5 Scar conditions and fibrosis of skin
0.000 0.936 0.064
E11.4 With neurological complications
0.064 0.936 0.000
E11.3 With ophthalmic complications
0.063 0.937 0.000
E73.9 Lactose intolerance, unspecified
0.061 0.939 0.000
D37-D48 Neoplasms of uncertain or unknown behaviour
0.058 0.942 0.000
E80.4 Gilbert's syndrome
0.057 0.943 0.000
E89.3 Postprocedural hypopituitarism
0.056 0.943 0.000
E74.3 Other disorders of intestinal carbohydrate absorption
0.055 0.945 0.000
K76.6 Portal hypertension
0.000 0.945 0.055
D40 Neoplasm of uncertain or unknown behaviour of male genital organs
0.053 0.947 0.000
L90.9 Atrophic disorder of skin, unspecified
0.000 0.948 0.052
L90.8 Other atrophic disorders of skin
0.000 0.948 0.052
L90.6 Striae atrophicae
0.000 0.948 0.052
L90.4 Acrodermatitis chronica atrophicans
0.000 0.948 0.052
L90.3 Atrophoderma of Pasini and Pierini
0.000 0.948 0.052
L90.2 Anetoderma of Jadassohn-Pellizzari
0.000 0.948 0.052
L90.1 Anetoderma of Schweninger-Buzzi
0.000 0.948 0.052
D47 Other neoplasms of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue
0.051 0.949 0.000
D40.0 Prostate
0.049 0.951 0.000
D44 Neoplasm of uncertain or unknown behaviour of endocrine glands
0.049 0.951 0.000
K76 Other diseases of liver
0.000 0.952 0.048
K70-K77 Diseases of liver
0.000 0.952 0.048
D41.0 Kidney
0.048 0.952 0.000
K72 Hepatic failure, not elsewhere classified
0.000 0.952 0.048
E53.8 Deficiency of other specified B group vitamins
0.046 0.953 0.001
D39 Neoplasm of uncertain or unknown behaviour of female genital organs
0.047 0.953 0.000
K72.9 Hepatic failure, unspecified
0.000 0.953 0.047
D38 Neoplasm of uncertain or unknown behaviour of middle ear and respiratory and intrathoracic organs
0.047 0.953 0.000
D41.9 Urinary organ, unspecified
0.046 0.953 0.000
D41.7 Other urinary organs
0.046 0.953 0.000
D41.3 Urethra
0.046 0.953 0.000
D41.2 Ureter
0.046 0.953 0.000
D41.1 Renal pelvis
0.046 0.953 0.000
D47.3 Essential (haemorrhagic) thrombocythaemia
0.046 0.954 0.000
E89.0 Postprocedural hypothyroidism
0.045 0.955 0.000
D46 Myelodysplastic syndromes
0.043 0.957 0.000
N42.8 Other specified disorders of prostate
0.000 0.957 0.042
D40.1 Testis
0.043 0.957 0.000
K75 Other inflammatory liver diseases
0.000 0.958 0.042
K74 Fibrosis and cirrhosis of liver
0.000 0.958 0.042
D42 Neoplasm of uncertain or unknown behaviour of meninges
0.042 0.958 0.000
D47.2 Monoclonal gammopathy
0.041 0.959 0.000
K76.8 Other specified diseases of liver
0.000 0.959 0.041
K74.6 Other and unspecified cirrhosis of liver
0.000 0.959 0.041
K73 Chronic hepatitis, not elsewhere classified
0.000 0.960 0.040
D47.1 Chronic myeloproliferative disease
0.040 0.960 0.000
K75.8 Other specified inflammatory liver diseases
0.000 0.960 0.040
D39.7 Other female genital organs
0.039 0.961 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.039 0.961 0.000
K72.0 Acute and subacute hepatic failure
0.000 0.961 0.039
D40.9 Male genital organ, unspecified
0.038 0.961 0.000
D40.7 Other male genital organs
0.038 0.961 0.000
D38.1 Trachea, bronchus and lung
0.038 0.961 0.000
D44.3 Pituitary gland
0.038 0.962 0.000
Chapter XX External causes of morbidity and mortality
0.038 0.962 0.000
D43 Neoplasm of uncertain or unknown behaviour of brain and central nervous system
0.038 0.962 0.000
D44.0 Thyroid gland
0.038 0.962 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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