TreeWAS – Variant ID: rs2071699

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
Chapter XIII Diseases of the musculoskeletal system and connective tissue	0.965	0.035	0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes	0.954	0.046	0.000
# Top node	0.953	0.047	0.000
I30-I52 Other forms of heart disease	0.952	0.048	0.000
M05-M14 Inflammatory polyarthropathies	0.952	0.048	0.000
M20-M25 Other joint disorders	0.952	0.048	0.000
M25 Other joint disorders, not elsewhere classified	0.950	0.050	0.000
T80-T88 Complications of surgical and medical care, not elsewhere classified	0.948	0.052	0.000
Chapter IX Diseases of the circulatory system	0.943	0.057	0.000
I51 Complications and ill-defined descriptions of heart disease	0.941	0.059	0.000
M06 Other rheumatoid arthritis	0.936	0.064	0.000
Chapter XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	0.935	0.065	0.000
R90-R94 Abnormal findings on diagnostic imaging and in function studies, without diagnosis	0.932	0.068	0.000
I51.7 Cardiomegaly	0.930	0.070	0.000
R91 Abnormal findings on diagnostic imaging of lung	0.929	0.071	0.000
M06.9 Rheumatoid arthritis, unspecified	0.921	0.079	0.000
Chapter XV Pregnancy, childbirth and the puerperium	0.912	0.088	0.000
T84 Complications of internal orthopaedic prosthetic devices, implants and grafts	0.910	0.090	0.000
I49 Other cardiac arrhythmias	0.902	0.098	0.000
O60-O75 Complications of labour and delivery	0.892	0.108	0.000
M15-M19 Arthrosis	0.890	0.110	0.000
M25.5 Pain in joint	0.887	0.113	0.000
M25.7 Osteophyte	0.883	0.117	0.000
R50-R69 General symptoms and signs	0.877	0.123	0.000
M25.4 Effusion of joint	0.874	0.126	0.000
M16 Coxarthrosis [arthrosis of hip]	0.870	0.130	0.000
I44 Atrioventricular and left bundle-branch block	0.869	0.131	0.000
T82 Complications of cardiac and vascular prosthetic devices, implants and grafts	0.868	0.132	0.000
I49.9 Cardiac arrhythmia, unspecified	0.845	0.155	0.000
M70-M79 Other soft tissue disorders	0.843	0.157	0.000
O68 Labour and delivery complicated by foetal stress [distress]	0.842	0.158	0.000
S70-S79 Injuries to the hip and thigh	0.839	0.161	0.000
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)	0.832	0.168	0.000
I35 Nonrheumatic aortic valve disorders	0.830	0.170	0.000
I70-I79 Diseases of arteries, arterioles and capillaries	0.827	0.173	0.000
M16.1 Other primary coxarthrosis	0.825	0.175	0.000
M25.46 Effusion of joint (Lower leg)	0.819	0.181	0.000
T84.1 Mechanical complication of internal fixation device of bones of limb	0.816	0.184	0.000
M06.94 Rheumatoid arthritis, unspecified (Hand)	0.812	0.188	0.000
R59 Enlarged lymph nodes	0.812	0.188	0.000
R60 Oedema, not elsewhere classified	0.811	0.189	0.000
M25.56 Pain in joint (Lower leg)	0.809	0.191	0.000
R63 Symptoms and signs concerning food and fluid intake	0.808	0.192	0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes	0.805	0.195	0.000
S80-S89 Injuries to the knee and lower leg	0.805	0.195	0.000
I47 Paroxysmal tachycardia	0.804	0.196	0.000
R20-R23 Symptoms and signs involving the skin and subcutaneous tissue	0.804	0.196	0.000
M25.6 Stiffness of joint, not elsewhere classified	0.799	0.201	0.000
O68.0 Labour and delivery complicated by foetal heart rate anomaly	0.794	0.206	0.000
M91-M94 Chondropathies	0.791	0.209	0.000
T84.0 Mechanical complication of internal joint prosthesis	0.789	0.211	0.000
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)	0.788	0.212	0.000
I44.7 Left bundle-branch block, unspecified	0.788	0.212	0.000
I77 Other disorders of arteries and arterioles	0.786	0.214	0.000
T83 Complications of genito-urinary prosthetic devices, implants and grafts	0.785	0.215	0.000
T36-T50 Poisoning by drugs, medicaments and biological substances	0.784	0.216	0.000
M10 Gout	0.782	0.218	0.000
R63.4 Abnormal weight loss	0.770	0.230	0.000
M65-M68 Disorders of synovium and tendon	0.769	0.231	0.000
S60-S69 Injuries to the wrist and hand	0.765	0.235	0.000
T84.5 Infection and inflammatory reaction due to internal joint prosthesis	0.762	0.238	0.000
M25.51 Pain in joint (Shoulder region)	0.761	0.238	0.000
M18 Arthrosis of first carpometacarpal joint	0.760	0.240	0.000
M25.75 Osteophyte (Pelvic region and thigh)	0.760	0.240	0.000
R25-R29 Symptoms and signs involving the nervous and musculoskeletal systems	0.760	0.240	0.000
I49.5 Sick sinus syndrome	0.759	0.241	0.000
R60.9 Oedema, unspecified	0.754	0.246	0.000
M25.76 Osteophyte (Lower leg)	0.753	0.247	0.000
O00-O08 Pregnancy with abortive outcome	0.752	0.248	0.000
M25.53 Pain in joint (Forearm)	0.752	0.248	0.000
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)	0.749	0.251	0.000
R54 Senility	0.749	0.251	0.000
T81 Complications of procedures, not elsewhere classified	0.748	0.252	0.000
M86-M90 Other osteopathies	0.747	0.253	0.000
M25.8 Other specified joint disorders	0.747	0.253	0.000
M06.3 Rheumatoid nodule	0.743	0.257	0.000
T82.1 Mechanical complication of cardiac electronic device	0.743	0.257	0.000
I44.2 Atrioventricular block, complete	0.741	0.259	0.000
T79-T79 Certain early complications of trauma	0.739	0.261	0.000
R59.0 Localised enlarged lymph nodes	0.738	0.262	0.000
I35.0 Aortic (valve) stenosis	0.737	0.263	0.000
T66-T78 Other and unspecified effects of external causes	0.733	0.267	0.000
T88 Other complications of surgical and medical care, not elsewhere classified	0.732	0.268	0.000
M07 Psoriatic and enteropathic arthropathies	0.731	0.269	0.000
T86 Failure and rejection of transplanted organs and tissues	0.731	0.269	0.000
R83-R89 Abnormal findings on examination of other body fluids, substances and tissues, without diagnosis	0.730	0.270	0.000
M25.74 Osteophyte (Hand)	0.729	0.271	0.000
M25.50 Pain in joint (Multiple sites)	0.728	0.272	0.000
I34 Nonrheumatic mitral valve disorders	0.727	0.273	0.000
O73 Retained placenta and membranes, without haemorrhage	0.726	0.274	0.000
T84.6 Infection and inflammatory reaction due to internal fixation device [any site]	0.722	0.278	0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue	0.722	0.278	0.000
O68.1 Labour and delivery complicated by meconium in amniotic fluid	0.722	0.278	0.000
I46 Cardiac arrest	0.721	0.279	0.000
R80-R82 Abnormal findings on examination of urine, without diagnosis	0.720	0.279	0.000
I45 Other conduction disorders	0.719	0.281	0.000
M16.0 Primary coxarthrosis, bilateral	0.719	0.281	0.000
I51.8 Other ill-defined heart diseases	0.718	0.282	0.000
I51.9 Heart disease, unspecified	0.715	0.285	0.000
I30 Acute pericarditis	0.714	0.286	0.000
S20-S29 Injuries to the thorax	0.713	0.287	0.000
M05 Seropositive rheumatoid arthritis	0.712	0.288	0.000
R90 Abnormal findings on diagnostic imaging of central nervous system	0.712	0.288	0.000
M75 Shoulder lesions	0.712	0.288	0.000
O66 Other obstructed labour	0.711	0.289	0.000
O70 Perineal laceration during delivery	0.711	0.289	0.000
M80-M85 Disorders of bone density and structure	0.711	0.289	0.000
T82.7 Infection and inflammatory reaction due to other cardiac and vascular devices, implants and grafts	0.710	0.290	0.000
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation	0.709	0.291	0.000
O75 Other complications of labour and delivery, not elsewhere classified	0.703	0.297	0.000
I05-I09 Chronic rheumatic heart diseases	0.702	0.298	0.000
I77.1 Stricture of artery	0.702	0.298	0.000
I49.0 Ventricular fibrillation and flutter	0.700	0.299	0.000
I47.2 Ventricular tachycardia	0.700	0.300	0.000
M79 Other soft tissue disorders, not elsewhere classified	0.700	0.300	0.000
T84.4 Mechanical complication of other internal orthopaedic devices, imnplants and grafts	0.699	0.301	0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis	0.697	0.303	0.000
O69 Labour and delivery complicated by umbilical cord complications	0.696	0.304	0.000
S80 Superficial injury of lower leg	0.695	0.305	0.000
I49.1 Atrial premature depolarisation	0.694	0.306	0.000
S79 Other and unspecified injuries of hip and thigh	0.693	0.307	0.000
T92 Sequelae of injuries of upper limb	0.692	0.308	0.000
I77.6 Arteritis, unspecified	0.692	0.308	0.000
M60-M63 Disorders of muscles	0.692	0.308	0.000
M00-M03 Infectious arthropathies	0.692	0.308	0.000
M25.66 Stiffness of joint, not elsewhere classified (Lower leg)	0.691	0.309	0.000
R94 Abnormal results of function studies	0.691	0.309	0.000
M16.3 Other dysplastic coxarthrosis	0.690	0.309	0.000
M06.96 Rheumatoid arthritis, unspecified (Lower leg)	0.689	0.311	0.000
R20 Disturbances of skin sensation	0.687	0.313	0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities	0.686	0.314	0.000
M24 Other specific joint derangements	0.685	0.315	0.000
M40-M43 Deforming dorsopathies	0.684	0.315	0.000
T33-T35 Frostbite	0.684	0.316	0.000
T26-T28 Burns and corrosions confined to eye and internal organs	0.684	0.316	0.000
T20-T25 Burns and corrosions of external body surface, specified by site	0.684	0.316	0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region	0.684	0.316	0.000
T00-T07 Injuries involving multiple body regions	0.684	0.316	0.000
S10-S19 Injuries to the neck	0.684	0.316	0.000
M21 Other acquired deformities of limbs	0.684	0.316	0.000
S50-S59 Injuries to the elbow and forearm	0.683	0.317	0.000
Chapter XVI Certain conditions originating in the perinatal period	0.683	0.317	0.000
I52 Other heart disorders in diseases classified elsewhere	0.683	0.317	0.000
I48 Atrial fibrillation and flutter	0.683	0.317	0.000
I43 Cardiomyopathy in diseases classified elsewhere	0.683	0.317	0.000
I41 Myocarditis in diseases classified elsewhere	0.683	0.317	0.000
I40 Acute myocarditis	0.683	0.317	0.000
I39 Endocarditis and heart valve disorders in diseases classified elsewhere	0.683	0.317	0.000
I37 Pulmonary valve disorders	0.683	0.317	0.000
I36 Nonrheumatic tricuspid valve disorders	0.683	0.317	0.000
I33 Acute and subacute endocarditis	0.683	0.317	0.000
I32 Pericarditis in diseases classified elsewhere	0.683	0.317	0.000
M14 Arthropathies in other diseases classified elsewhere	0.682	0.318	0.000
M12 Other specific arthropathies	0.682	0.318	0.000
M09 Juvenile arthritis in diseases classified elsewhere	0.682	0.318	0.000
M08 Juvenile arthritis	0.682	0.318	0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere	0.682	0.318	0.000
M34 Systemic sclerosis	0.682	0.318	0.000
M33 Dermatopolymyositis	0.682	0.318	0.000
M32 Systemic lupus erythematosus	0.682	0.318	0.000
M30 Polyarteritis nodosa and related conditions	0.682	0.318	0.000
R40-R46 Symptoms and signs involving cognition, perception, emotional state and behaviour	0.682	0.318	0.000
M75.4 Impingement syndrome of shoulder	0.682	0.318	0.000
M25.9 Joint disorder, unspecified	0.681	0.319	0.000
M25.3 Other instability of joint	0.681	0.319	0.000
M25.2 Flail joint	0.681	0.319	0.000
M25.1 Fistula of joint	0.681	0.319	0.000
M25.0 Haemarthrosis	0.681	0.319	0.000
T87 Complications peculiar to reattachment and amputation	0.680	0.320	0.000
T80 Complications following infusion, transfusion and therapeutic injection	0.680	0.320	0.000
I00-I02 Acute rheumatic fever	0.676	0.324	0.000
I51.6 Cardiovascular disease, unspecified	0.675	0.325	0.000
I51.5 Myocardial degeneration	0.675	0.325	0.000
I51.4 Myocarditis, unspecified	0.675	0.325	0.000
I51.3 Intracardiac thrombosis, not elsewhere classified	0.675	0.325	0.000
I51.2 Rupture of papillary muscle, not elsewhere classified	0.675	0.325	0.000
I51.1 Rupture of chordae tendineae, not elsewhere classified	0.675	0.325	0.000
I51.0 Cardiac septal defect, acquired	0.675	0.325	0.000
I50 Heart failure	0.675	0.325	0.000
S90-S99 Injuries to the ankle and foot	0.674	0.326	0.000
M16.7 Other secondary coxarthrosis	0.673	0.327	0.000
M31 Other necrotising vasculopathies	0.672	0.328	0.000
S64 Injury of nerves at wrist and hand level	0.672	0.328	0.000
M06.8 Other specified rheumatoid arthritis	0.671	0.329	0.000
M06.4 Inflammatory polyarthropathy	0.671	0.329	0.000
M06.2 Rheumatoid bursitis	0.671	0.329	0.000
M06.1 Adult-onset Still's disease	0.671	0.329	0.000
M06.0 Seronegative rheumatoid arthritis	0.671	0.329	0.000
R95-R99 Ill-defined and unknown causes of mortality	0.670	0.330	0.000
T81.0 Haemorrhage and haematoma complicating a procedure, not elsewhere classified	0.670	0.330	0.000
T82.8 Other complications of cardiac and vascular prosthetic devices, implants and grafts	0.669	0.331	0.000
R92 Abnormal findings on diagnostic imaging of breast	0.668	0.332	0.000
S72 Fracture of femur	0.662	0.338	0.000
R23 Other skin changes	0.662	0.338	0.000
M10.9 Gout, unspecified	0.661	0.339	0.000
M06.98 Rheumatoid arthritis, unspecified (Other)	0.660	0.340	0.000
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)	0.660	0.340	0.000
M06.93 Rheumatoid arthritis, unspecified (Forearm)	0.660	0.340	0.000
M06.92 Rheumatoid arthritis, unspecified (Upper arm)	0.660	0.340	0.000
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)	0.660	0.340	0.000
Chapter XII Diseases of the skin and subcutaneous tissue	0.659	0.341	0.000
I38 Endocarditis, valve unspecified	0.659	0.341	0.000
R51 Headache	0.659	0.341	0.000
S71 Open wound of hip and thigh	0.657	0.343	0.000
O63 Long labour	0.656	0.344	0.000
M16.9 Coxarthrosis, unspecified	0.656	0.344	0.000
T82.5 Mechanical complication of other cardiac and vascular devices and implants	0.655	0.345	0.000
R93 Abnormal findings on diagnostic imaging of other body structures	0.654	0.346	0.000
O85-O92 Complications predominantly related to the puerperium	0.654	0.346	0.000
T84.9 Unspecified complication of internal orthopaedic prosthetic device, implant and graft	0.652	0.348	0.000
T84.7 Infection and inflammatory reaction due to other internal orthopaedic prosthetic devices, implants and grafts	0.652	0.348	0.000
T84.3 Mechanical complication of other bone devices, implants and grafts	0.652	0.348	0.000
I44.1 Atrioventricular block, second degree	0.650	0.350	0.000
O10-O16 Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium	0.649	0.351	0.000
M93 Other osteochondropathies	0.649	0.351	0.000
Chapter XXII Codes for special purposes	0.648	0.352	0.000
I49.2 Junctional premature depolarisation	0.647	0.353	0.000
M77 Other enthesopathies	0.646	0.354	0.000
M13 Other arthritis	0.645	0.355	0.000
R68 Other general symptoms and signs	0.645	0.355	0.000
M25.71 Osteophyte (Shoulder region)	0.644	0.356	0.000
O30-O48 Maternal care related to the fetus and amniotic cavity and possible delivery problems	0.644	0.356	0.000
R29 Other symptoms and signs involving the nervous and musculoskeletal systems	0.644	0.356	0.000
M18.1 Other primary arthrosis of first carpometacarpal joint	0.643	0.357	0.000
M11 Other crystal arthropathies	0.640	0.360	0.000
S00-S09 Injuries to the head	0.640	0.360	0.000
O74 Complications of anaesthesia during labour and delivery	0.640	0.360	0.000
O71 Other obstetric trauma	0.640	0.360	0.000
O67 Labour and delivery complicated by intrapartum haemorrhage, not elsewhere classified	0.640	0.360	0.000
O65 Obstructed labour due to maternal pelvic abnormality	0.640	0.360	0.000
O61 Failed induction of labour	0.640	0.360	0.000
O60 Preterm delivery	0.640	0.360	0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions	0.639	0.361	0.000
I35.1 Aortic (valve) insufficiency	0.639	0.361	0.000
R59.9 Enlarged lymph nodes, unspecified	0.638	0.362	0.000
M15 Polyarthrosis	0.638	0.362	0.000
T83.0 Mechanical complication of urinary (indwelling) catheter	0.638	0.362	0.000
M25.59 Pain in joint (Site unspecified)	0.636	0.364	0.000
M25.58 Pain in joint (Other)	0.636	0.364	0.000
M25.54 Pain in joint (Hand)	0.636	0.364	0.000
M25.52 Pain in joint (Upper arm)	0.636	0.364	0.000
M25.79 Osteophyte (Site unspecified)	0.633	0.367	0.000
M25.73 Osteophyte (Forearm)	0.633	0.367	0.000
M25.72 Osteophyte (Upper arm)	0.633	0.367	0.000
M25.70 Osteophyte (Multiple sites)	0.633	0.367	0.000
O62 Abnormalities of forces of labour	0.632	0.368	0.000
O20-O29 Other maternal disorders predominantly related to pregnancy	0.630	0.370	0.000
T15-T19 Effects of foreign body entering through natural orifice	0.630	0.370	0.000
M67 Other disorders of synovium and tendon	0.630	0.370	0.000
R65 Systemic Inflammatory Response Syndrome [SIRS]	0.629	0.371	0.000
R62 Lack of expected normal physiological development	0.629	0.371	0.000
R57 Shock, not elsewhere classified	0.629	0.371	0.000
R64 Cachexia	0.629	0.371	0.000
R58 Haemorrhage, not elsewhere classified	0.629	0.371	0.000
M25.49 Effusion of joint (Site unspecified)	0.626	0.374	0.000
M25.48 Effusion of joint (Other)	0.626	0.374	0.000
M25.47 Effusion of joint (Ankle and foot)	0.626	0.374	0.000
M25.45 Effusion of joint (Pelvic region and thigh)	0.626	0.374	0.000
M25.44 Effusion of joint (Hand)	0.626	0.374	0.000
M25.43 Effusion of joint (Forearm)	0.626	0.374	0.000
M25.42 Effusion of joint (Upper arm)	0.626	0.374	0.000
M25.41 Effusion of joint (Shoulder region)	0.626	0.374	0.000
M25.40 Effusion of joint (Multiple sites)	0.626	0.374	0.000
Chapter II Neoplasms	0.626	0.374	0.000
M16.6 Other secondary coxarthrosis, bilateral	0.624	0.376	0.000
M16.5 Other posttraumatic coxarthrosis	0.624	0.376	0.000
M16.4 Posttraumatic coxarthrosis, bilateral	0.624	0.376	0.000
M16.2 Coxarthrosis resulting from dysplasia, bilateral	0.624	0.376	0.000
I44.6 Other and unspecified fascicular block	0.623	0.377	0.000
I44.5 Left posterior fascicular block	0.623	0.377	0.000
I44.4 Left anterior fascicular block	0.623	0.377	0.000
I44.3 Other and unspecified atrioventricular block	0.623	0.377	0.000
R60.0 Localised oedema	0.623	0.377	0.000
T82.9 Unspecified complication of cardiac and vascular prosthetic device, implant and graft	0.623	0.377	0.000
T82.6 Infection and inflammatory reaction due to cardiac valve prosthesis	0.623	0.377	0.000
T82.4 Mechanical complication of vascular dialysis catheter	0.623	0.377	0.000
T82.3 Mechanical complication of other vascular grafts	0.623	0.377	0.000
T82.2 Mechanical complication of coronary artery bypass and valve grafts	0.623	0.377	0.000
T82.0 Mechanical complication of heart valve prosthesis	0.623	0.377	0.000
I71 Aortic aneurysm and dissection	0.622	0.378	0.000
M20 Acquired deformities of fingers and toes	0.620	0.380	0.000
M70 Soft tissue disorders related to use, overuse and pressure	0.620	0.380	0.000
I49.8 Other specified cardiac arrhythmias	0.620	0.380	0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source	0.618	0.381	0.000
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs	0.618	0.382	0.000
R59.1 Generalised enlarged lymph nodes	0.618	0.382	0.000
S81 Open wound of lower leg	0.617	0.383	0.000
D10-D36 Benign neoplasms	0.617	0.383	0.000
R56 Convulsions, not elsewhere classified	0.615	0.385	0.000
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances	0.614	0.386	0.000
D25 Leiomyoma of uterus	0.614	0.386	0.000
M79.7 Fibromyalgia	0.613	0.387	0.000
O64 Obstructed labour due to malposition and malpresentation of foetus	0.611	0.389	0.000
R53 Malaise and fatigue	0.611	0.389	0.000
I27 Other pulmonary heart diseases	0.610	0.390	0.000
O73.0 Retained placenta, without haemorrhage	0.607	0.393	0.000
S80.9 Superficial injury of lower leg, unspecified	0.607	0.393	0.000
D25.9 Leiomyoma of uterus, unspecified	0.606	0.394	0.000
O03 Spontaneous abortion	0.606	0.394	0.000
I77.9 Disorder of arteries and arterioles, unspecified	0.606	0.394	0.000
R20.8 Other and unspecified disturbances of skin sensation	0.606	0.394	0.000
M25.77 Osteophyte (Ankle and foot)	0.605	0.395	0.000
S64.4 Injury of digital nerve of other finger	0.605	0.395	0.000
M06.34 Rheumatoid nodule (Hand)	0.605	0.395	0.000
M76 Enthesopathies of lower limb, excluding foot	0.604	0.395	0.000
M73 Soft tissue disorders in diseases classified elsewhere	0.604	0.395	0.000
O68.3 Labour and delivery complicated by biochemical evidence of foetal stress	0.603	0.396	0.000
I70 Atherosclerosis	0.603	0.397	0.000
T81.8 Other complications of procedures, not elsewhere classified	0.603	0.397	0.000
M71 Other bursopathies	0.603	0.397	0.000
S70 Superficial injury of hip and thigh	0.603	0.397	0.000
I74 Arterial embolism and thrombosis	0.603	0.397	0.000
I49.4 Other and unspecified premature depolarisation	0.603	0.397	0.000
M22 Disorders of patella	0.602	0.398	0.000
S78 Traumatic amputation of hip and thigh	0.601	0.398	0.000
S77 Crushing injury of hip and thigh	0.601	0.398	0.000
S76 Injury of muscle and tendon at hip and thigh level	0.601	0.398	0.000
S75 Injury of blood vessels at hip and thigh level	0.601	0.398	0.000
S74 Injury of nerves at hip and thigh level	0.601	0.398	0.000
S73 Dislocation, sprain and strain of joint and ligaments of hip	0.601	0.398	0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	0.601	0.399	0.000
T81.9 Unspecified complication of procedure	0.599	0.401	0.000
T90 Sequelae of injuries of head	0.598	0.402	0.000
I34.1 Mitral (valve) prolapse	0.598	0.402	0.000
T84.2 Mechanical complication of internal fixation device of other bones	0.596	0.404	0.000
I42 Cardiomyopathy	0.596	0.404	0.000
I35.9 Aortic valve disorder, unspecified	0.595	0.405	0.000
I35.8 Other aortic valve disorders	0.595	0.405	0.000
M23 Internal derangement of knee	0.595	0.405	0.000
T83.5 Infection and inflammatory reaction due to prosthetic device, implant and graft in urinary system	0.595	0.405	0.000
O68.9 Labour and delivery complicated by foetal stress, unspecified	0.595	0.405	0.000
M94 Other disorders of cartilage	0.594	0.405	0.000
M25.78 Osteophyte (Other)	0.594	0.406	0.000
S40-S49 Injuries to the shoulder and upper arm	0.594	0.406	0.000
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere	0.593	0.407	0.000
I72 Other aneurysm	0.593	0.407	0.000
M25.84 Other specified joint disorders (Hand)	0.593	0.407	0.000
I45.8 Other specified conduction disorders	0.591	0.408	0.000
I45.6 Preexcitation syndrome	0.589	0.411	0.000
M18.9 Arthrosis of first carpometacarpal joint, unspecified	0.589	0.411	0.000
R22 Localised swelling, mass and lump of skin and subcutaneous tissue	0.588	0.412	0.000
S79.9 Unspecified injury of hip and thigh	0.588	0.412	0.000
T43 Poisoning by psychotropic drugs, not elsewhere classified	0.588	0.412	0.000
O70.1 Second degree perineal laceration during delivery	0.588	0.412	0.000
T79 Certain early complications of trauma, not elsewhere classified	0.584	0.416	0.000
R60.1 Generalised oedema	0.582	0.418	0.000
O66.5 Failed application of vacuum extractor and forceps, unspecified	0.581	0.418	0.000
T88.4 Failed or difficult intubation	0.581	0.419	0.000
R63.6 Insufficient intake of food and water due to self neglect	0.580	0.420	0.000
R63.5 Abnormal weight gain	0.580	0.420	0.000
R63.3 Feeding difficulties and mismanagement	0.580	0.420	0.000
R63.2 Polyphagia	0.580	0.420	0.000
R63.1 Polydipsia	0.580	0.420	0.000
T83.3 Mechanical complication of intra-uterine contraceptive device	0.578	0.422	0.000
I46.9 Cardiac arrest, unspecified	0.578	0.422	0.000
T98 Sequelae of other and unspecified effects of external causes	0.577	0.423	0.000
T95 Sequelae of burns, corrosions and frostbite	0.577	0.423	0.000
T94 Sequelae of injuries involving multiple and unspecified body regions	0.577	0.423	0.000
T91 Sequelae of injuries of neck and trunk	0.577	0.423	0.000
T97 Sequelae of toxic effects of substances chiefly nonmedicinal as to source	0.577	0.423	0.000
T96 Sequelae of poisoning by drugs, medicaments and biological substances	0.577	0.423	0.000
S89 Other and unspecified injuries of lower leg	0.577	0.423	0.000
S88 Traumatic amputation of lower leg	0.577	0.423	0.000
S87 Crushing injury of lower leg	0.577	0.423	0.000
S86 Injury of muscle and tendon at lower leg level	0.577	0.423	0.000
S85 Injury of blood vessels at lower leg level	0.577	0.423	0.000
S84 Injury of nerves at lower leg level	0.577	0.423	0.000
O04 Medical abortion	0.577	0.423	0.000
I47.9 Paroxysmal tachycardia, unspecified	0.577	0.423	0.000
I47.0 Reentry ventricular arrhythmia	0.577	0.423	0.000
L20-L30 Dermatitis and eczema	0.576	0.424	0.000
T86.1 Kidney transplant failure and rejection	0.575	0.425	0.000
R63.8 Other symptoms and signs concerning food and fluid intake	0.575	0.425	0.000
C64-C68 Malignant neoplasms of urinary tract	0.575	0.425	0.000
T85 Complications of other internal prosthetic devices, implants and grafts	0.574	0.426	0.000
T78 Adverse effects, not elsewhere classified	0.574	0.426	0.000
M10.99 Gout, unspecified (Site unspecified)	0.573	0.427	0.000
I47.1 Supraventricular tachycardia	0.573	0.427	0.000
M07.3 Other psoriatic arthropathies	0.573	0.427	0.000
M25.69 Stiffness of joint, not elsewhere classified (Site unspecified)	0.573	0.427	0.000
M25.68 Stiffness of joint, not elsewhere classified (Other)	0.573	0.427	0.000
M25.67 Stiffness of joint, not elsewhere classified (Ankle and foot)	0.573	0.427	0.000
M25.65 Stiffness of joint, not elsewhere classified (Pelvic region and thigh)	0.573	0.427	0.000
M25.64 Stiffness of joint, not elsewhere classified (Hand)	0.573	0.427	0.000
M25.63 Stiffness of joint, not elsewhere classified (Forearm)	0.573	0.427	0.000
M25.62 Stiffness of joint, not elsewhere classified (Upper arm)	0.573	0.427	0.000
M25.61 Stiffness of joint, not elsewhere classified (Shoulder region)	0.573	0.427	0.000
M25.60 Stiffness of joint, not elsewhere classified (Multiple sites)	0.573	0.427	0.000
M89 Other disorders of bone	0.572	0.428	0.000
S02 Fracture of skull and facial bones	0.571	0.429	0.000
M75.2 Bicipital tendinitis	0.571	0.429	0.000
T92.1 Sequelae of fracture of arm	0.569	0.431	0.000
S82 Fracture of lower leg, including ankle	0.569	0.431	0.001
O94-O99 Other obstetric conditions, not elsewhere classified	0.568	0.432	0.000
O70.2 Third degree perineal laceration during delivery	0.567	0.433	0.000
M92 Other juvenile osteochondrosis	0.567	0.433	0.000
M91 Juvenile osteochondrosis of hip and pelvis	0.567	0.433	0.000
R80 Isolated proteinuria	0.567	0.433	0.000
T93 Sequelae of injuries of lower limb	0.566	0.434	0.000
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics	0.566	0.434	0.000
R40 Somnolence, stupor and coma	0.565	0.435	0.000
T92.2 Sequelae of fracture at wrist and hand level	0.564	0.436	0.000
I77.8 Other specified disorders of arteries and arterioles	0.564	0.436	0.000
I77.5 Necrosis of artery	0.564	0.436	0.000
I77.4 Coeliac artery compression syndrome	0.564	0.436	0.000
I77.3 Arterial fibromuscular dysplasia	0.564	0.436	0.000
I77.2 Rupture of artery	0.564	0.436	0.000
I77.0 Arteriovenous fistula, acquired	0.564	0.436	0.000
I49.3 Ventricular premature depolarisation	0.563	0.436	0.000
T83.9 Unspecified complication of genito-urinary prosthetic device, implant and graft	0.563	0.437	0.000
T83.8 Other complications of genito-urinary prosthetic devices, implants and grafts	0.563	0.437	0.000
T83.6 Infection and inflammatory reaction due to prosthetic device, implant and graft in genital tract	0.563	0.437	0.000
T83.4 Mechanical complication of other prosthetic devices, implants and grafts in genital tract	0.563	0.437	0.000
T83.2 Mechanical complication of graft of urinary organ	0.563	0.437	0.000
T83.1 Mechanical complication of other urinary devices and implants	0.563	0.437	0.000
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs	0.562	0.438	0.000
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system	0.562	0.438	0.000
T47 Poisoning by agents primarily affecting gastro-intestinal system	0.562	0.438	0.000
T46 Poisoning by agents primarily affecting the cardiovascular system	0.562	0.438	0.000
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified	0.562	0.438	0.000
T44 Poisoning by drugs primarily affecting the autonomic nervous system	0.562	0.438	0.000
T41 Poisoning by anaesthetics and therapeutic gases	0.562	0.438	0.000
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified	0.562	0.438	0.000
T37 Poisoning by other systemic anti-infectives and antiparasitics	0.562	0.438	0.000
T36 Poisoning by systemic antibiotics	0.562	0.438	0.000
I35.2 Aortic (valve) stenosis with insufficiency	0.561	0.439	0.000
M10.4 Other secondary gout	0.561	0.439	0.000
M10.3 Gout due to impairment of renal function	0.561	0.439	0.000
M10.2 Drug-induced gout	0.561	0.439	0.000
M10.1 Lead-induced gout	0.561	0.439	0.000
M10.0 Idiopathic gout	0.561	0.439	0.000
R87 Abnormal findings in specimens from female genital organs	0.559	0.441	0.000
R25 Abnormal involuntary movements	0.558	0.442	0.000
I50.0 Congestive heart failure	0.558	0.442	0.000
I05 Rheumatic mitral valve diseases	0.557	0.443	0.000
O69.2 Labour and delivery complicated by other cord entanglement	0.556	0.444	0.000
O63.9 Long labour, unspecified	0.556	0.444	0.000
O68.8 Labour and delivery complicated by other evidence of foetal stress	0.555	0.445	0.000
R90.0 Intracranial space-occupying lesion	0.555	0.445	0.000
S62 Fracture at wrist and hand level	0.554	0.446	0.000
R85 Abnormal findings in specimens from digestive organs and abdominal cavity	0.553	0.447	0.000
S68 Traumatic amputation of wrist and hand	0.553	0.447	0.000
O68.2 Labour and delivery complicated by foetal heart rate anomaly with meconium in amniotic fluid	0.553	0.447	0.000
R26 Abnormalities of gait and mobility	0.553	0.447	0.000
M41 Scoliosis	0.552	0.448	0.000
L00-L08 Infections of the skin and subcutaneous tissue	0.552	0.448	0.000
M68 Disorders of synovium and tendon in diseases classified elsewhere	0.551	0.449	0.000
M66 Spontaneous rupture of synovium and tendon	0.551	0.449	0.000
I31 Other diseases of pericardium	0.551	0.449	0.000
O42 Premature rupture of membranes	0.551	0.449	0.000
O02 Other abnormal products of conception	0.551	0.449	0.000
M79.79 Fibromyalgia (Site unspecified)	0.550	0.450	0.000
O72 Postpartum haemorrhage	0.549	0.451	0.000
M86 Osteomyelitis	0.548	0.451	0.000
M65 Synovitis and tenosynovitis	0.548	0.452	0.000
S69 Other and unspecified injuries of wrist and hand	0.548	0.452	0.000
S67 Crushing injury of wrist and hand	0.548	0.452	0.000
S65 Injury of blood vessels at wrist and hand level	0.548	0.452	0.000
S63 Dislocation, sprain and strain of joints and ligaments at wrist and hand level	0.548	0.452	0.000
M95 Other acquired deformities of musculoskeletal system and connective tissue	0.548	0.452	0.000
R70-R79 Abnormal findings on examination of blood, without diagnosis	0.547	0.453	0.000
M93.9 Osteochondropathy, unspecified	0.547	0.453	0.000
M25.86 Other specified joint disorders (Lower leg)	0.547	0.453	0.000
D25.2 Subserosal leiomyoma of uterus	0.546	0.454	0.000
M88 Paget's disease of bone [osteitis deformans]	0.546	0.454	0.000
M18.5 Other secondary arthrosis of first carpometacarpal joint	0.545	0.455	0.000
M18.4 Other secondary arthrosis of first carpometacarpal joints, bilateral	0.545	0.455	0.000
M18.3 Other posttraumatic arthrosis of first carpometacarpal joint	0.545	0.455	0.000
M18.2 Posttraumatic arthrosis of first carpometacarpal joints, bilateral	0.545	0.455	0.000
M18.0 Primary arthrosis of first carpometacarpal joints, bilateral	0.545	0.455	0.000
S60 Superficial injury of wrist and hand	0.544	0.455	0.000
R93.5 Abnormal findings on diagnostic imaging of other abdominal regions, including retroperitoneum	0.544	0.456	0.000
S83 Dislocation, sprain and strain of joints and ligaments of knee	0.544	0.456	0.000
I30.9 Acute pericarditis, unspecified	0.543	0.457	0.000
M80 Osteoporosis with pathological fracture	0.543	0.457	0.000
R47-R49 Symptoms and signs involving speech and voice	0.541	0.459	0.000
M05.9 Seropositive rheumatoid arthritis, unspecified	0.541	0.459	0.000
R50 Fever of unknown origin	0.541	0.459	0.000
O03.4 Incomplete, without complication	0.540	0.459	0.000
R23.1 Pallor	0.540	0.460	0.000
O08 Complications following abortion and ectopic and molar pregnancy	0.539	0.460	0.000
O07 Failed attempted abortion	0.539	0.460	0.000
O06 Unspecified abortion	0.539	0.460	0.000
O05 Other abortion	0.539	0.460	0.000
O01 Hydatidiform mole	0.539	0.460	0.000
O00 Ectopic pregnancy	0.539	0.460	0.000
R44 Other symptoms and signs involving general sensations and perceptions	0.539	0.461	0.000
M20.4 Other hammer toe(s) (acquired)	0.539	0.461	0.000
L50-L54 Urticaria and erythema	0.538	0.461	0.000
C67 Malignant neoplasm of bladder	0.538	0.462	0.000
O75.8 Other specified complications of labour and delivery	0.537	0.463	0.000
T81.7 Vascular complications following a procedure, not elsewhere classified	0.536	0.464	0.000
T81.6 Acute reaction to foreign substance accidentally left during a procedure	0.536	0.464	0.000
T81.5 Foreign body accidentally left in body cavity or operation wound following a procedure	0.536	0.464	0.000
T81.1 Shock during or resulting from a procedure, not elsewhere classified	0.536	0.464	0.000
S22 Fracture of rib(s), sternum and thoracic spine	0.536	0.464	0.000
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]	0.536	0.464	0.000
M90 Osteopathies in diseases classified elsewhere	0.535	0.464	0.000
M87 Osteonecrosis	0.535	0.464	0.000
S61 Open wound of wrist and hand	0.536	0.464	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations