TreeWAS – Variant ID: rs2076529

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
M05.99 Seropositive rheumatoid arthritis, unspecified (Site unspecified)	1.000	0.000	0.000
M05.90 Seropositive rheumatoid arthritis, unspecified (Multiple sites)	1.000	0.000	0.000
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)	1.000	0.000	0.000
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)	1.000	0.000	0.000
J45.9 Asthma, unspecified	1.000	0.000	0.000
K90.0 Coeliac disease	0.000	0.000	1.000
M05.9 Seropositive rheumatoid arthritis, unspecified	1.000	0.000	0.000
M06.9 Rheumatoid arthritis, unspecified	1.000	0.000	0.000
D86 Sarcoidosis	0.000	0.000	1.000
G35 Multiple sclerosis	0.000	0.000	1.000
M06 Other rheumatoid arthritis	1.000	0.000	0.000
M05-M14 Inflammatory polyarthropathies	1.000	0.000	0.000
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)	1.000	0.000	0.000
M06.96 Rheumatoid arthritis, unspecified (Lower leg)	1.000	0.000	0.000
M05 Seropositive rheumatoid arthritis	1.000	0.000	0.000
E10 Insulin-dependent diabetes mellitus	1.000	0.000	0.000
M45.X9 Ankylosing spondylitis (Site unspecified)	1.000	0.000	0.000
M45 Ankylosing spondylitis	1.000	0.000	0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue	1.000	0.000	0.000
D86.0 Sarcoidosis of lung	0.000	0.000	1.000
M06.3 Rheumatoid nodule	1.000	0.000	0.000
M35.3 Polymyalgia rheumatica	1.000	0.000	0.000
E10.9 Without complications	1.000	0.000	0.000
M45-M49 Spondylopathies	1.000	0.000	0.000
M06.94 Rheumatoid arthritis, unspecified (Hand)	1.000	0.000	0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	0.000	0.001	0.999
D80-D89 Certain disorders involving the immune mechanism	0.000	0.001	0.999
M20-M25 Other joint disorders	0.999	0.001	0.000
M06.0 Seronegative rheumatoid arthritis	0.999	0.001	0.000
M35 Other systemic involvement of connective tissue	0.999	0.001	0.000
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)	0.998	0.002	0.000
J30-J39 Other diseases of upper respiratory tract	0.998	0.002	0.000
J33 Nasal polyp	0.998	0.002	0.000
J33.9 Nasal polyp, unspecified	0.998	0.002	0.000
J38 Diseases of vocal cords and larynx, not elsewhere classified	0.997	0.003	0.000
M06.34 Rheumatoid nodule (Hand)	0.997	0.003	0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions	0.000	0.003	0.997
R31 Unspecified haematuria	0.997	0.003	0.000
J45 Asthma	0.994	0.006	0.000
D86.9 Sarcoidosis, unspecified	0.000	0.007	0.993
E10.3 With ophthalmic complications	0.993	0.007	0.000
E05.0 Thyrotoxicosis with diffuse goitre	0.000	0.008	0.992
J40-J47 Chronic lower respiratory diseases	0.990	0.010	0.000
D68 Other coagulation defects	0.000	0.010	0.990
J38.3 Other diseases of vocal cords	0.988	0.012	0.000
D50-D53 Nutritional anaemias	0.000	0.012	0.988
J32 Chronic sinusitis	0.984	0.016	0.000
M31 Other necrotising vasculopathies	0.983	0.017	0.000
E10.4 With neurological complications	0.982	0.018	0.000
Chapter X Diseases of the respiratory system	0.979	0.021	0.000
M06.4 Inflammatory polyarthropathy	0.979	0.021	0.000
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)	0.977	0.023	0.000
M31.6 Other giant cell arteritis	0.975	0.025	0.000
M20 Acquired deformities of fingers and toes	0.974	0.026	0.000
M06.00 Seronegative rheumatoid arthritis (Multiple sites)	0.973	0.027	0.000
D51 Vitamin B12 deficiency anaemia	0.000	0.029	0.971
M06.09 Seronegative rheumatoid arthritis (Site unspecified)	0.969	0.031	0.000
E05 Thyrotoxicosis [hyperthyroidism]	0.003	0.038	0.959
J32.9 Chronic sinusitis, unspecified	0.961	0.039	0.000
M05.97 Seropositive rheumatoid arthritis, unspecified (Ankle and foot)	0.959	0.041	0.000
M65-M68 Disorders of synovium and tendon	0.956	0.044	0.000
E05.9 Thyrotoxicosis, unspecified	0.000	0.044	0.956
M20.4 Other hammer toe(s) (acquired)	0.946	0.054	0.000
D86.3 Sarcoidosis of skin	0.000	0.054	0.946
E10.1 With ketoacidosis	0.940	0.060	0.000
J38.7 Other diseases of larynx	0.939	0.061	0.000
M06.49 Inflammatory polyarthropathy (Site unspecified)	0.938	0.062	0.000
M06.93 Rheumatoid arthritis, unspecified (Forearm)	0.937	0.063	0.000
J46 Status asthmaticus	0.936	0.064	0.000
J47 Bronchiectasis	0.935	0.065	0.000
E10.5 With peripheral circulatory complications	0.934	0.066	0.000
M06.92 Rheumatoid arthritis, unspecified (Upper arm)	0.931	0.069	0.000
M65 Synovitis and tenosynovitis	0.930	0.070	0.000
D52 Folate deficiency anaemia	0.000	0.070	0.930
M45.X0 Ankylosing spondylitis (Multiple sites in spine)	0.928	0.072	0.000
D51.0 Vitamin B12 deficiency anaemia due to intrinsic factor deficiency	0.000	0.072	0.928
M30 Polyarteritis nodosa and related conditions	0.926	0.074	0.000
D68.8 Other specified coagulation defects	0.000	0.075	0.925
M06.32 Rheumatoid nodule (Upper arm)	0.918	0.082	0.000
D51.9 Vitamin B12 deficiency anaemia, unspecified	0.000	0.084	0.916
E10.6 With other specified complications	0.908	0.092	0.000
D60-D64 Aplastic and other anaemias	0.000	0.097	0.903
D55-D59 Haemolytic anaemias	0.000	0.097	0.903
M65.9 Synovitis and tenosynovitis, unspecified	0.898	0.102	0.000
M05.96 Seropositive rheumatoid arthritis, unspecified (Lower leg)	0.896	0.104	0.000
D65 Disseminated intravascular coagulation [defibrination syndrome]	0.000	0.107	0.893
D61 Other aplastic anaemias	0.000	0.109	0.891
M05.1 Rheumatoid lung disease	0.890	0.110	0.000
D52.9 Folate deficiency anaemia, unspecified	0.000	0.112	0.888
M46 Other inflammatory spondylopathies	0.883	0.117	0.000
J38.4 Oedema of larynx	0.882	0.118	0.000
J38.0 Paralysis of vocal cords and larynx	0.882	0.118	0.000
D61.9 Aplastic anaemia, unspecified	0.000	0.118	0.882
M05.94 Seropositive rheumatoid arthritis, unspecified (Hand)	0.879	0.121	0.000
M05.92 Seropositive rheumatoid arthritis, unspecified (Upper arm)	0.875	0.124	0.000
K90 Intestinal malabsorption	0.000	0.128	0.872
D68.2 Hereditary deficiency of other clotting factors	0.000	0.129	0.871
M05.8 Other seropositive rheumatoid arthritis	0.865	0.135	0.000
M14 Arthropathies in other diseases classified elsewhere	0.865	0.135	0.000
E10.0 With coma	0.862	0.138	0.000
M20.5 Other deformities of toe(s) (acquired)	0.862	0.138	0.000
D86.1 Sarcoidosis of lymph nodes	0.000	0.140	0.860
D68.5 Primary Thrombophilia	0.000	0.143	0.857
D59 Acquired haemolytic anaemia	0.000	0.143	0.857
M06.98 Rheumatoid arthritis, unspecified (Other)	0.856	0.144	0.000
M06.37 Rheumatoid nodule (Ankle and foot)	0.855	0.145	0.000
J32.4 Chronic pansinusitis	0.854	0.146	0.000
J38.5 Laryngeal spasm	0.847	0.153	0.000
M65.90 Synovitis and tenosynovitis, unspecified (Multiple sites)	0.847	0.153	0.000
J95-J99 Other diseases of the respiratory system	0.843	0.157	0.000
M20.6 Acquired deformity of toe(s), unspecified	0.842	0.158	0.000
M45.X2 Ankylosing spondylitis (Cervical region)	0.841	0.159	0.000
M06.07 Seronegative rheumatoid arthritis (Ankle and foot)	0.836	0.164	0.000
D86.8 Sarcoidosis of other and combined sites	0.000	0.165	0.835
J42 Unspecified chronic bronchitis	0.835	0.165	0.000
M05.95 Seropositive rheumatoid arthritis, unspecified (Pelvic region and thigh)	0.834	0.166	0.000
M06.01 Seronegative rheumatoid arthritis (Shoulder region)	0.833	0.167	0.000
M65.91 Synovitis and tenosynovitis, unspecified (Shoulder region)	0.831	0.169	0.000
M06.40 Inflammatory polyarthropathy (Multiple sites)	0.831	0.169	0.000
M06.33 Rheumatoid nodule (Forearm)	0.830	0.170	0.000
J32.0 Chronic maxillary sinusitis	0.825	0.175	0.000
M30.1 Polyarteritis with lung involvement [Churg-Strauss]	0.825	0.175	0.000
J35 Chronic diseases of tonsils and adenoids	0.821	0.179	0.000
M65.94 Synovitis and tenosynovitis, unspecified (Hand)	0.820	0.180	0.000
D89 Other disorders involving the immune mechanism, not elsewhere classified	0.000	0.186	0.814
M06.30 Rheumatoid nodule (Multiple sites)	0.814	0.186	0.000
J85-J86 Suppurative and necrotic conditions of lower respiratory tract	0.813	0.187	0.000
M65.4 Radial styloid tenosynovitis [de Quervain]	0.812	0.188	0.000
D68.6 Other Thrombophilia	0.000	0.190	0.810
M08 Juvenile arthritis	0.810	0.190	0.000
M05.93 Seropositive rheumatoid arthritis, unspecified (Forearm)	0.808	0.192	0.000
M06.05 Seronegative rheumatoid arthritis (Pelvic region and thigh)	0.808	0.192	0.000
D59.1 Other autoimmune haemolytic anaemias	0.000	0.194	0.806
J32.2 Chronic ethmoidal sinusitis	0.805	0.195	0.000
M20.1 Hallux valgus (acquired)	0.803	0.197	0.000
M46.1 Sacro-iliitis, not elsewhere classified	0.803	0.197	0.000
G35-G37 Demyelinating diseases of the central nervous system	0.000	0.199	0.801
M34 Systemic sclerosis	0.799	0.201	0.000
J99 Respiratory disorders in diseases classified elsewhere	0.798	0.202	0.000
M31.7 Microscopic polyangiitis	0.797	0.202	0.000
D68.3 Haemorrhagic disorder due to circulating anticoagulants	0.000	0.206	0.794
M06.46 Inflammatory polyarthropathy (Lower leg)	0.793	0.207	0.000
K90.4 Malabsorption due to intolerance, not elsewhere classified	0.000	0.210	0.790
D69 Purpura and other haemorrhagic conditions	0.000	0.211	0.789
D68.0 Von Willebrand's disease	0.000	0.212	0.788
J45.1 Nonallergic asthma	0.787	0.213	0.000
M66 Spontaneous rupture of synovium and tendon	0.786	0.214	0.000
J33.0 Polyp of nasal cavity	0.783	0.217	0.000
M14.6 Neuropathic arthropathy	0.780	0.220	0.000
M12 Other specific arthropathies	0.772	0.228	0.000
M65.93 Synovitis and tenosynovitis, unspecified (Forearm)	0.770	0.230	0.000
D68.1 Hereditary factor XI deficiency	0.000	0.231	0.769
M65.1 Other infective (teno)synovitis	0.768	0.232	0.000
D68.4 Acquired coagulation factor deficiency	0.000	0.236	0.764
G37 Other demyelinating diseases of central nervous system	0.000	0.238	0.762
D61.0 Constitutional aplastic anaemia	0.000	0.239	0.761
D66 Hereditary factor VIII deficiency	0.000	0.239	0.761
J45.8 Mixed asthma	0.759	0.241	0.000
J32.1 Chronic frontal sinusitis	0.758	0.242	0.000
M05.10 Rheumatoid lung disease (Multiple sites)	0.757	0.242	0.000
M06.04 Seronegative rheumatoid arthritis (Hand)	0.757	0.243	0.000
M35.1 Other overlap syndromes	0.754	0.246	0.000
M20.0 Deformity of finger(s)	0.753	0.247	0.000
J35.8 Other chronic diseases of tonsils and adenoids	0.753	0.247	0.000
J99.0 Rheumatoid lung disease	0.752	0.248	0.000
M30.0 Polyarteritis nodosa	0.750	0.250	0.000
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes	0.000	0.258	0.742
M05.19 Rheumatoid lung disease (Site unspecified)	0.741	0.259	0.000
J33.1 Polypoid sinus degeneration	0.741	0.259	0.000
M31.5 Giant cell arteritis with polymyalgia rheumatica	0.739	0.261	0.000
M06.8 Other specified rheumatoid arthritis	0.739	0.261	0.000
K90.9 Intestinal malabsorption, unspecified	0.000	0.267	0.733
M31.9 Necrotising vasculopathy, unspecified	0.731	0.269	0.000
M46.18 Sacroiliitis, not elsewhere classified-Sacral/sacrococ	0.727	0.273	0.000
M65.43 Radial styloid tenosynovitis [de Quervain] (Forearm)	0.725	0.275	0.000
M05.80 Other seropositive rheumatoid arthritis (Multiple sites)	0.725	0.275	0.000
M30.8 Other conditions related to polyarteritis nodosa	0.724	0.276	0.000
K90.8 Other intestinal malabsorption	0.000	0.278	0.722
E10.8 With unspecified complications	0.722	0.278	0.000
E10.2 With renal complications	0.721	0.279	0.000
M65.92 Synovitis and tenosynovitis, unspecified (Upper arm)	0.719	0.281	0.000
M31.8 Other specified necrotising vasculopathies	0.719	0.281	0.000
D59.9 Acquired haemolytic anaemia, unspecified	0.000	0.283	0.717
M05.98 Seropositive rheumatoid arthritis, unspecified (Other)	0.717	0.283	0.000
M06.2 Rheumatoid bursitis	0.717	0.283	0.000
M06.1 Adult-onset Still's disease	0.717	0.283	0.000
M09 Juvenile arthritis in diseases classified elsewhere	0.717	0.283	0.000
M05.3 Rheumatoid arthritis with involvement of other organs and systems	0.717	0.283	0.000
M05.0 Felty's syndrome	0.717	0.283	0.000
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)	0.717	0.283	0.000
M45.X7 Ankylosing spondylitis (Lumbosacral region)	0.717	0.283	0.000
M45.X5 Ankylosing spondylitis (Thoracolumbar region)	0.717	0.283	0.000
M45.X4 Ankylosing spondylitis (Thoracic region)	0.717	0.283	0.000
M45.X3 Ankylosing spondylitis (Cervicothoracic region)	0.717	0.283	0.000
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)	0.717	0.283	0.000
M06.39 Rheumatoid nodule (Site unspecified)	0.717	0.283	0.000
M06.38 Rheumatoid nodule (Other)	0.717	0.283	0.000
M06.36 Rheumatoid nodule (Lower leg)	0.717	0.283	0.000
M06.35 Rheumatoid nodule (Pelvic region and thigh)	0.717	0.283	0.000
M06.31 Rheumatoid nodule (Shoulder region)	0.717	0.283	0.000
D81 Combined immunodeficiencies	0.000	0.283	0.716
M06.08 Seronegative rheumatoid arthritis (Other)	0.716	0.284	0.000
M06.03 Seronegative rheumatoid arthritis (Forearm)	0.716	0.284	0.000
M06.02 Seronegative rheumatoid arthritis (Upper arm)	0.716	0.284	0.000
M35.9 Systemic involvement of connective tissue, unspecified	0.716	0.284	0.000
M35.6 Relapsing panniculitis [Weber-Christian]	0.716	0.284	0.000
M35.5 Multifocal fibrosclerosis	0.716	0.284	0.000
M35.4 Diffuse (eosinophilic) fasciitis	0.716	0.284	0.000
M35.8 Other specified systemic involvement of connective tissue	0.716	0.284	0.000
M31.4 Aortic arch syndrome [Takayasu]	0.715	0.285	0.000
D69.3 Idiopathic thrombocytopenic purpura	0.000	0.285	0.715
M00-M03 Infectious arthropathies	0.711	0.289	0.000
J38.6 Stenosis of larynx	0.711	0.289	0.000
J85 Abscess of lung and mediastinum	0.707	0.293	0.000
E10.7 With multiple complications	0.706	0.294	0.000
M31.2 Lethal midline granuloma	0.704	0.295	0.000
M05.2 Rheumatoid vasculitis	0.702	0.298	0.000
M06.48 Inflammatory polyarthropathy (Other)	0.702	0.298	0.000
M06.47 Inflammatory polyarthropathy (Ankle and foot)	0.702	0.298	0.000
M06.45 Inflammatory polyarthropathy (Pelvic region and thigh)	0.702	0.298	0.000
M06.44 Inflammatory polyarthropathy (Hand)	0.702	0.298	0.000
M06.43 Inflammatory polyarthropathy (Forearm)	0.702	0.298	0.000
M06.42 Inflammatory polyarthropathy (Upper arm)	0.702	0.298	0.000
M06.41 Inflammatory polyarthropathy (Shoulder region)	0.702	0.298	0.000
D82 Immunodeficiency associated with other major defects	0.000	0.301	0.698
E10-E14 Diabetes mellitus	0.687	0.302	0.010
D89.9 Disorder involving the immune mechanism, unspecified	0.000	0.303	0.697
M35.2 Behcet's disease	0.697	0.303	0.000
M05.89 Other seropositive rheumatoid arthritis (Site unspecified)	0.697	0.303	0.000
D51.2 Transcobalamin II deficiency	0.000	0.304	0.696
D51.1 Vitamin B12 deficiency anaemia due to selective vitamin B12 malabsorption with proteinuria	0.000	0.304	0.696
D89.0 Polyclonal hypergammaglobulinaemia	0.000	0.306	0.694
J99.8 Respiratory disorders in other diseases classified elsewhere	0.692	0.308	0.000
G37.9 Demyelinating disease of central nervous system, unspecified	0.000	0.308	0.692
E05.5 Thyroid crisis or storm	0.002	0.310	0.687
E05.4 Thyrotoxicosis factitia	0.002	0.310	0.687
E05.3 Thyrotoxicosis from ectopic thyroid tissue	0.002	0.310	0.687
M36 Systemic disorders of connective tissue in diseases classified elsewhere	0.689	0.311	0.000
D51.8 Other vitamin B12 deficiency anaemias	0.000	0.311	0.689
M06.06 Seronegative rheumatoid arthritis (Lower leg)	0.689	0.311	0.000
M91-M94 Chondropathies	0.686	0.314	0.000
M68 Disorders of synovium and tendon in diseases classified elsewhere	0.685	0.315	0.000
J31 Chronic rhinitis, nasopharyngitis and pharyngitis	0.680	0.320	0.000
M46.2 Osteomyelitis of vertebra	0.678	0.322	0.000
M46.4 Discitis, unspecified	0.677	0.323	0.000
J37 Chronic laryngitis and laryngotracheitis	0.675	0.324	0.000
M08.0 Juvenile rheumatoid arthritis	0.673	0.326	0.000
M49 Spondylopathies in diseases classified elsewhere	0.672	0.328	0.000
M05.91 Seropositive rheumatoid arthritis, unspecified (Shoulder region)	0.672	0.328	0.000
J35.2 Hypertrophy of adenoids	0.671	0.329	0.000
E27.1 Primary adrenocortical insufficiency	0.000	0.329	0.671
J41 Simple and mucopurulent chronic bronchitis	0.669	0.331	0.000
M66.5 Spontaneous rupture of unspecified tendon	0.667	0.333	0.000
M65.0 Abscess of tendon sheath	0.667	0.333	0.000
D52.8 Other folate deficiency anaemias	0.000	0.333	0.666
D52.1 Drug-induced folate deficiency anaemia	0.000	0.333	0.666
D52.0 Dietary folate deficiency anaemia	0.000	0.333	0.666
M60-M63 Disorders of muscles	0.665	0.335	0.000
M30.3 Mucocutaneous lymph node syndrome [Kawasaki]	0.664	0.336	0.000
M30.2 Juvenile polyarteritis	0.664	0.336	0.000
M14.2 Diabetic arthropathy	0.659	0.341	0.000
M46.3 Infection of intervertebral disk (pyogenic)	0.658	0.342	0.000
J09-J18 Influenza and pneumonia	0.657	0.343	0.000
D57 Sickle-cell disorders	0.000	0.344	0.656
J95 Postprocedural respiratory disorders, not elsewhere classified	0.656	0.344	0.000
M65.2 Calcific tendinitis	0.655	0.345	0.000
D56 Thalassaemia	0.000	0.346	0.654
M65.14 Other infective (teno)synovitis (Hand)	0.652	0.348	0.000
D55 Anaemia due to enzyme disorders	0.000	0.353	0.647
M65.98 Synovitis and tenosynovitis, unspecified (Other)	0.644	0.356	0.000
J32.3 Chronic sphenoidal sinusitis	0.643	0.357	0.000
M65.8 Other synovitis and tenosynovitis	0.641	0.359	0.000
M34.1 CR(E)ST syndrome	0.640	0.359	0.000
D83 Common variable immunodeficiency	0.000	0.361	0.639
D61.8 Other specified aplastic anaemias	0.000	0.361	0.639
D61.3 Idiopathic aplastic anaemia	0.000	0.361	0.639
D61.2 Aplastic anaemia due to other external agents	0.000	0.361	0.639
M66.2 Spontaneous rupture of extensor tendons	0.638	0.362	0.000
M05.18 Rheumatoid lung disease (Other)	0.638	0.362	0.000
M05.17 Rheumatoid lung disease (Ankle and foot)	0.638	0.362	0.000
M05.16 Rheumatoid lung disease (Lower leg)	0.638	0.362	0.000
M05.15 Rheumatoid lung disease (Pelvic region and thigh)	0.638	0.362	0.000
M05.14 Rheumatoid lung disease (Hand)	0.638	0.362	0.000
M05.13 Rheumatoid lung disease (Forearm)	0.638	0.362	0.000
M05.12 Rheumatoid lung disease (Upper arm)	0.638	0.362	0.000
M05.11 Rheumatoid lung disease (Shoulder region)	0.638	0.362	0.000
M46.8 Other specified inflammatory spondylopathies	0.633	0.367	0.000
M46.5 Other infective spondylopathies	0.633	0.367	0.000
J33.8 Other polyp of sinus	0.632	0.368	0.000
G37.8 Other specified demyelinating diseases of central nervous system	0.000	0.368	0.632
M46.0 Spinal enthesopathy	0.631	0.369	0.000
M46.19 Sacroiliitis, not elsewhere classified-Site unspe	0.630	0.370	0.000
M40-M43 Deforming dorsopathies	0.625	0.375	0.000
K90.3 Pancreatic steatorrhoea	0.000	0.375	0.625
K90.2 Blind loop syndrome, not elsewhere classified	0.000	0.375	0.625
K90.1 Tropical sprue	0.000	0.375	0.625
E27 Other disorders of adrenal gland	0.000	0.376	0.624
D60 Acquired pure red cell aplasia [erythroblastopenia]	0.000	0.378	0.622
M95-M99 Other disorders of the musculoskeletal system and connective tissue	0.622	0.378	0.000
D53 Other nutritional anaemias	0.000	0.379	0.620
M05.88 Other seropositive rheumatoid arthritis (Other)	0.620	0.380	0.000
M05.87 Other seropositive rheumatoid arthritis (Ankle and foot)	0.620	0.380	0.000
M05.86 Other seropositive rheumatoid arthritis (Lower leg)	0.620	0.380	0.000
M05.85 Other seropositive rheumatoid arthritis (Pelvic region and thigh)	0.620	0.380	0.000
M05.84 Other seropositive rheumatoid arthritis (Hand)	0.620	0.380	0.000
M05.83 Other seropositive rheumatoid arthritis (Forearm)	0.620	0.380	0.000
M05.82 Other seropositive rheumatoid arthritis (Upper arm)	0.620	0.380	0.000
M05.81 Other seropositive rheumatoid arthritis (Shoulder region)	0.620	0.380	0.000
D69.4 Other primary thrombocytopenia	0.000	0.380	0.620
M14.5 Arthropathies in other endocrine, nutritional and metabolic disorders	0.620	0.380	0.000
M14.4 Arthropathy in amyloidosis	0.620	0.380	0.000
M14.3 Lipoid dermatoarthritis	0.620	0.380	0.000
M14.1 Crystal arthropathy in other metabolic disorders	0.620	0.380	0.000
M14.0 Gouty arthropathy due to enzyme defects and other inherited disorders	0.620	0.380	0.000
D84 Other immunodeficiencies	0.000	0.380	0.619
M45.X6 Ankylosing spondylitis (Lumbar region)	0.619	0.381	0.000
D69.6 Thrombocytopenia, unspecified	0.000	0.382	0.618
D59.8 Other acquired haemolytic anaemias	0.000	0.386	0.614
D59.6 Haemoglobinuria due to haemolysis from other external causes	0.000	0.386	0.614
D59.5 Paroxysmal nocturnal haemoglobinuria [Marchiafava-Micheli]	0.000	0.386	0.614
D59.3 Haemolytic-uraemic syndrome	0.000	0.386	0.614
D59.2 Drug-induced nonautoimmune haemolytic anaemia	0.000	0.386	0.614
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system	0.000	0.386	0.614
D67 Hereditary factor IX deficiency	0.000	0.387	0.612
M12.3 Palindromic rheumatism	0.611	0.389	0.000
M65.99 Synovitis and tenosynovitis, unspecified (Site unspecified)	0.611	0.389	0.000
D59.0 Drug-induced autoimmune haemolytic anaemia	0.000	0.391	0.609
M66.3 Spontaneous rupture of flexor tendons	0.608	0.392	0.000
M31.3 Wegener's granulomatosis	0.607	0.393	0.000
J96 Respiratory failure, not elsewhere classified	0.605	0.395	0.000
J85.1 Abscess of lung with pneumonia	0.602	0.397	0.000
E05.1 Thyrotoxicosis with toxic single thyroid nodule	0.003	0.399	0.598
E14 Unspecified diabetes mellitus	0.598	0.401	0.001
M13 Other arthritis	0.599	0.401	0.000
M34.8 Other forms of systemic sclerosis	0.596	0.404	0.000
M48 Other spondylopathies	0.595	0.405	0.000
D51.3 Other dietary vitamin B12 deficiency anaemia	0.000	0.405	0.595
M65.44 Radial styloid tenosynovitis [de Quervain] (Hand)	0.592	0.408	0.000
J35.1 Hypertrophy of tonsils	0.591	0.409	0.000
D70-D77 Other diseases of blood and blood-forming organs	0.000	0.411	0.589
J35.3 Hypertrophy of tonsils with hypertrophy of adenoids	0.589	0.411	0.000
D59.4 Other nonautoimmune haemolytic anaemias	0.000	0.413	0.587
D89.3 Immune reconstitution syndrome	0.000	0.416	0.584
M65.49 Radial styloid tenosynovitis [de Quervain]-Site unspec	0.582	0.417	0.000
M65.48 Radial styloid tenosynovitis [de Quervain]-Other	0.582	0.417	0.000
M65.47 Radial styloid tenosynovitis [de Quervain]-Ankle/foot	0.582	0.417	0.000
M65.46 Radial styloid tenosynovitis [de Quervain]-Lower leg	0.582	0.417	0.000
M65.45 Radial styloid tenosynovitis [de Quervain]-Pelvic/thigh	0.582	0.417	0.000
M65.42 Radial styloid tenosynovitis [de Quervain]-Upper arm	0.582	0.417	0.000
M65.41 Radial styloid tenosynovitis [de Quervain]-Shldr region	0.582	0.417	0.000
M65.40 Radial styloid tenosynovitis [de Quervain] (Multiple sites)	0.582	0.417	0.000
M08.9 Juvenile arthritis, unspecified	0.581	0.419	0.000
M08.8 Other juvenile arthritis	0.581	0.419	0.000
M08.4 Pauciarticular juvenile arthritis	0.581	0.419	0.000
M08.3 Juvenile polyarthritis (seronegative)	0.581	0.419	0.000
M08.2 Juvenile arthritis with systemic onset	0.581	0.419	0.000
M08.1 Juvenile ankylosing spondylitis	0.581	0.419	0.000
E20-E35 Disorders of other endocrine glands	0.001	0.420	0.579
M31.1 Thrombotic microangiopathy	0.580	0.420	0.000
D69.1 Qualitative platelet defects	0.000	0.420	0.580
J38.1 Polyp of vocal cord and larynx	0.577	0.423	0.000
M08.00 Juvenile rheumatoid arthritis (Multiple sites)	0.576	0.424	0.000
J85.0 Gangrene and necrosis of lung	0.576	0.424	0.000
M46.17 Sacroiliitis, not elsewhere classified-Lumbosacral	0.575	0.424	0.000
M46.16 Sacroiliitis, not elsewhere classified-Lumbar	0.575	0.424	0.000
M46.15 Sacroiliitis, not elsewhere classified-Thoracolumbar	0.575	0.424	0.000
M46.14 Sacroiliitis, not elsewhere classified-Thoracic	0.575	0.424	0.000
M46.13 Sacroiliitis, not elsewhere classified-Cervicothoracic	0.575	0.424	0.000
M46.12 Sacroiliitis, not elsewhere classified-Cervical	0.575	0.424	0.000
M46.11 Sacroiliitis, not elsewhere classified-Occipit-atl-axl	0.575	0.424	0.000
M46.10 Sacroiliitis, not elsewhere classified-Mult site	0.575	0.424	0.000
R17 Unspecified jaundice	0.000	0.426	0.574
M34.2 Systemic sclerosis induced by drugs and chemicals	0.573	0.427	0.000
M34.0 Progressive systemic sclerosis	0.573	0.427	0.000
M34.9 Systemic sclerosis, unspecified	0.571	0.429	0.000
J13 Pneumonia due to Streptococcus pneumoniae	0.570	0.430	0.000
M66.54 Spontaneous rupture of unspecified tendon (Hand)	0.567	0.433	0.000
M12.2 Villonodular synovitis (pigmented)	0.566	0.434	0.000
D69.8 Other specified haemorrhagic conditions	0.000	0.434	0.566
M66.24 Spontaneous rupture of extensor tendons (Hand)	0.565	0.435	0.000
M66.1 Rupture of synovium	0.564	0.436	0.000
E00-E07 Disorders of thyroid gland	0.096	0.437	0.467
M06.89 Other specified rheumatoid arthritis (Site unspecified)	0.562	0.438	0.000
M94 Other disorders of cartilage	0.562	0.438	0.000
J12 Viral pneumonia, not elsewhere classified	0.561	0.439	0.000
E14.3 With ophthalmic complications	0.560	0.440	0.000
E27.2 Addisonian crisis	0.000	0.443	0.557
M12.4 Intermittent hydrarthrosis	0.554	0.446	0.000
M12.1 Kaschin-Beck disease	0.554	0.446	0.000
M12.0 Chronic postrheumatic arthropathy [Jaccoud]	0.554	0.446	0.000
E22 Hyperfunction of pituitary gland	0.000	0.447	0.553
M60 Myositis	0.553	0.447	0.000
J86 Pyothorax	0.551	0.449	0.000
D69.0 Allergic purpura	0.000	0.449	0.551
M65.19 Other infective (teno)synovitis (Site unspecified)	0.550	0.449	0.000
M65.18 Other infective (teno)synovitis (Other)	0.550	0.449	0.000
M65.17 Other infective (teno)synovitis (Ankle and foot)	0.550	0.449	0.000
M65.16 Other infective (teno)synovitis (Lower leg)	0.550	0.449	0.000
M65.15 Other infective (teno)synovitis (Pelvic region and thigh)	0.550	0.449	0.000
M65.13 Other infective (teno)synovitis (Forearm)	0.550	0.449	0.000
M65.12 Other infective (teno)synovitis (Upper arm)	0.550	0.449	0.000
M65.11 Other infective (teno)synovitis (Shoulder region)	0.550	0.449	0.000
M65.10 Other infective (teno)synovitis (Multiple sites)	0.550	0.449	0.000
D89.1 Cryoglobulinaemia	0.000	0.449	0.550
Chapter IV Endocrine, nutritional and metabolic diseases	0.096	0.450	0.454
M65.86 Other synovitis and tenosynovitis (Lower leg)	0.549	0.451	0.000
D73 Diseases of spleen	0.000	0.451	0.549
D62 Acute posthaemorrhagic anaemia	0.000	0.452	0.548
G37.5 Concentric sclerosis [Balo]	0.000	0.454	0.546
G37.4 Subacute necrotising myelitis	0.000	0.454	0.546
G37.2 Central pontine myelinolysis	0.000	0.454	0.546
G37.1 Central demyelination of corpus callosum	0.000	0.454	0.546
G37.0 Diffuse sclerosis	0.000	0.454	0.546
M12.5 Traumatic arthropathy	0.546	0.454	0.000
M12.8 Other specific arthropathies, not elsewhere classified	0.546	0.454	0.000
E13 Other specified diabetes mellitus	0.541	0.454	0.005
J11 Influenza, virus not identified	0.545	0.455	0.000
G36 Other acute disseminated demyelination	0.000	0.456	0.544
M46.46 Discitis, unspecified (Lumbar region)	0.543	0.457	0.000
M00 Pyogenic arthritis	0.538	0.462	0.000
M46.26 Osteomyelitis of vertebra (Lumbar region)	0.537	0.463	0.000
J16 Pneumonia due to other infectious organisms, not elsewhere classified	0.535	0.465	0.000
M66.0 Rupture of popliteal cyst	0.533	0.467	0.000
M05.20 Rheumatoid vasculitis (Multiple sites)	0.533	0.467	0.000
M46.47 Discitis, unspecified (Lumbosacral region)	0.532	0.468	0.000
M14.8 Arthropathies in other specified diseases classified elsewhere	0.530	0.469	0.000
M06.88 Other specified rheumatoid arthritis (Other)	0.530	0.470	0.000
M06.87 Other specified rheumatoid arthritis (Ankle and foot)	0.530	0.470	0.000
M06.86 Other specified rheumatoid arthritis (Lower leg)	0.530	0.470	0.000
M06.85 Other specified rheumatoid arthritis (Pelvic region and thigh)	0.530	0.470	0.000
M06.84 Other specified rheumatoid arthritis (Hand)	0.530	0.470	0.000
M06.83 Other specified rheumatoid arthritis (Forearm)	0.530	0.470	0.000
M06.82 Other specified rheumatoid arthritis (Upper arm)	0.530	0.470	0.000
M06.81 Other specified rheumatoid arthritis (Shoulder region)	0.530	0.470	0.000
E14.6 With other specified complications	0.528	0.471	0.000
M40 Kyphosis and lordosis	0.527	0.473	0.000
D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified	0.000	0.474	0.526
J35.9 Chronic disease of tonsils and adenoids, unspecified	0.525	0.475	0.000
M31.0 Hypersensitivity angiitis	0.523	0.477	0.000
M06.80 Other specified rheumatoid arthritis (Multiple sites)	0.518	0.482	0.000
E22.0 Acromegaly and pituitary gigantism	0.000	0.482	0.518
K40.9 Unilateral or unspecified inguinal hernia, without obstruction or gangrene	0.517	0.483	0.000
M91 Juvenile osteochondrosis of hip and pelvis	0.517	0.483	0.000
J95.0 Tracheostomy malfunction	0.515	0.485	0.000
M05.09 Felty's syndrome (Site unspecified)	0.514	0.486	0.000
M05.08 Felty's syndrome (Other)	0.514	0.486	0.000
M05.07 Felty's syndrome (Ankle and foot)	0.514	0.486	0.000
M05.06 Felty's syndrome (Lower leg)	0.514	0.486	0.000
M05.05 Felty's syndrome (Pelvic region and thigh)	0.514	0.486	0.000
M05.04 Felty's syndrome (Hand)	0.514	0.486	0.000
M05.03 Felty's syndrome (Forearm)	0.514	0.486	0.000
M05.02 Felty's syndrome (Upper arm)	0.514	0.486	0.000
M05.01 Felty's syndrome (Shoulder region)	0.514	0.486	0.000
M05.00 Felty's syndrome (Multiple sites)	0.514	0.486	0.000
M05.39 Rheumatoid arthritis with involvement of other organs and systems (Site unspecified)	0.514	0.486	0.000
M05.38 Rheumatoid arthritis with involvement of other organs and systems (Other)	0.514	0.486	0.000
M05.37 Rheumatoid arthritis with involvement of other organs and systems (Ankle and foot)	0.514	0.486	0.000
M05.36 Rheumatoid arthritis with involvement of other organs and systems (Lower leg)	0.514	0.486	0.000
M05.35 Rheumatoid arthritis with involvement of other organs and systems (Pelvic region and thigh)	0.514	0.486	0.000
M05.34 Rheumatoid arthritis with involvement of other organs and systems (Hand)	0.514	0.486	0.000
M05.33 Rheumatoid arthritis with involvement of other organs and systems (Forearm)	0.514	0.486	0.000
M05.32 Rheumatoid arthritis with involvement of other organs and systems (Upper arm)	0.514	0.486	0.000
M05.31 Rheumatoid arthritis with involvement of other organs and systems (Shoulder region)	0.514	0.486	0.000
M05.30 Rheumatoid arthritis with involvement of other organs and systems (Multiple sites)	0.514	0.486	0.000
M06.19 Adult-onset Still's disease (Site unspecified)	0.514	0.486	0.000
M06.18 Adult-onset Still's disease (Other)	0.514	0.486	0.000
M06.17 Adult-onset Still's disease (Ankle and foot)	0.514	0.486	0.000
M06.16 Adult-onset Still's disease (Lower leg)	0.514	0.486	0.000
M06.15 Adult-onset Still's disease (Pelvic region and thigh)	0.514	0.486	0.000
M06.14 Adult-onset Still's disease (Hand)	0.514	0.486	0.000
M06.13 Adult-onset Still's disease (Forearm)	0.514	0.486	0.000
M06.12 Adult-onset Still's disease (Upper arm)	0.514	0.486	0.000
M06.11 Adult-onset Still's disease (Shoulder region)	0.514	0.486	0.000
M06.10 Adult-onset Still's disease (Multiple sites)	0.514	0.486	0.000
M06.29 Rheumatoid bursitis (Site unspecified)	0.514	0.486	0.000
M06.28 Rheumatoid bursitis (Other)	0.514	0.486	0.000
M06.27 Rheumatoid bursitis (Ankle and foot)	0.514	0.486	0.000
M06.26 Rheumatoid bursitis (Lower leg)	0.514	0.486	0.000
M06.25 Rheumatoid bursitis (Pelvic region and thigh)	0.514	0.486	0.000
M06.24 Rheumatoid bursitis (Hand)	0.514	0.486	0.000
M06.23 Rheumatoid bursitis (Forearm)	0.514	0.486	0.000
M06.22 Rheumatoid bursitis (Upper arm)	0.514	0.486	0.000
M06.21 Rheumatoid bursitis (Shoulder region)	0.514	0.486	0.000
M06.20 Rheumatoid bursitis (Multiple sites)	0.514	0.486	0.000
M09.8 Juvenile arthritis in other diseases classified elsewhere	0.514	0.486	0.000
M09.2 Juvenile arthritis in ulcerative colitis	0.514	0.486	0.000
M09.1 Juvenile arthritis in Crohn's disease [regional enteritis]	0.514	0.486	0.000
M09.0 Juvenile arthritis in psoriasis	0.514	0.486	0.000
D81.9 Combined immunodeficiency, unspecified	0.000	0.486	0.514
D81.8 Other combined immunodeficiencies	0.000	0.486	0.514
D81.7 Major histocompatibility complex class II deficiency	0.000	0.486	0.514
D81.6 Major histocompatibility complex class I deficiency	0.000	0.486	0.514
D81.5 Purine nucleoside phosphorylase [PNP] deficiency	0.000	0.486	0.514
D81.4 Nezelof's syndrome	0.000	0.486	0.514
D81.3 Adenosine deaminase [ADA] deficiency	0.000	0.486	0.514
D81.2 Severe combined immunodeficiency [SCID] with low or normal B-cell numbers	0.000	0.486	0.514
D81.1 Severe combined immunodeficiency [SCID] with low T- and B-cell numbers	0.000	0.486	0.514
D81.0 Severe combined immunodeficiency [SCID] with reticular dysgenesis	0.000	0.486	0.514
M35.99 Systemic involvement of connective tissue, unspecified, Site unspecified	0.513	0.486	0.000
M03 Postinfective and reactive arthropathies in diseases classified elsewhere	0.510	0.490	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations