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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs209122
log Bayes Factor = 52.9959
Chromosome 6   position 28,875,502  (GRCh37) Explore rs209122 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E83.1 Disorders of iron metabolism
1.000 0.000 0.000
K90.0 Coeliac disease
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
E05.9 Thyrotoxicosis, unspecified
0.000 0.001 0.999
E10.9 Without complications
0.000 0.001 0.999
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.002 0.998
E10-E14 Diabetes mellitus
0.000 0.003 0.997
E16.2 Hypoglycaemia, unspecified
0.000 0.003 0.997
E16 Other disorders of pancreatic internal secretion
0.000 0.004 0.996
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.004 0.996
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.004 0.996
E10.3 With ophthalmic complications
0.000 0.004 0.996
E00-E07 Disorders of thyroid gland
0.000 0.006 0.994
E10.2 With renal complications
0.000 0.046 0.954
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.054 0.946
E10.1 With ketoacidosis
0.000 0.094 0.906
E10.4 With neurological complications
0.000 0.098 0.902
E05.8 Other thyrotoxicosis
0.000 0.186 0.814
E13 Other specified diabetes mellitus
0.000 0.207 0.793
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.208 0.792
E16.1 Other hypoglycaemia
0.000 0.220 0.780
E10.7 With multiple complications
0.000 0.250 0.750
I83.9 Varicose veins of lower extremities without ulcer or inflammation
0.728 0.272 0.000
E10.0 With coma
0.000 0.277 0.723
E05.5 Thyroid crisis or storm
0.000 0.285 0.715
E05.4 Thyrotoxicosis factitia
0.000 0.285 0.715
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.285 0.715
E12 Malnutrition-related diabetes mellitus
0.000 0.285 0.715
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.286 0.714
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.286 0.714
E16.4 Abnormal secretion of gastrin
0.000 0.286 0.714
E16.3 Increased secretion of glucagon
0.000 0.286 0.714
E15 Nondiabetic hypoglycaemic coma
0.000 0.286 0.714
E14 Unspecified diabetes mellitus
0.000 0.287 0.713
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.287 0.713
E00 Congenital iodine-deficiency syndrome
0.000 0.287 0.713
E40-E46 Malnutrition
0.000 0.305 0.695
E10.5 With peripheral circulatory complications
0.000 0.321 0.679
E13.9 Without complications
0.000 0.356 0.644
E10.6 With other specified complications
0.000 0.360 0.640
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.363 0.637
E07 Other disorders of thyroid
0.000 0.374 0.626
E14.3 With ophthalmic complications
0.000 0.389 0.611
E06 Thyroiditis
0.000 0.403 0.597
E14.1 With ketoacidosis
0.000 0.424 0.576
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.425 0.575
E13.3 With ophthalmic complications
0.000 0.427 0.573
E13.8 With unspecified complications
0.000 0.431 0.569
E13.7 With multiple complications
0.000 0.431 0.569
E13.6 With other specified complications
0.000 0.431 0.569
E13.5 With peripheral circulatory complications
0.000 0.431 0.569
E13.4 With neurological complications
0.000 0.431 0.569
E13.2 With renal complications
0.000 0.431 0.569
E13.1 With ketoacidosis
0.000 0.431 0.569
E13.0 With coma
0.000 0.431 0.569
E14.6 With other specified complications
0.000 0.457 0.542
E14.4 With neurological complications
0.000 0.468 0.531
E14.8 With unspecified complications
0.000 0.482 0.518
E12.9 Without complications
0.000 0.487 0.513
E12.8 With unspecified complications
0.000 0.487 0.513
E12.7 With multiple complications
0.000 0.487 0.513
E12.6 With other specified complications
0.000 0.487 0.513
E12.5 With peripheral circulatory complications
0.000 0.487 0.513
E12.4 With neurological complications
0.000 0.487 0.513
E12.3 With ophthalmic complications
0.000 0.487 0.513
E12.2 With renal complications
0.000 0.487 0.513
E12.1 With ketoacidosis
0.000 0.487 0.513
E12.0 With coma
0.000 0.487 0.513
E14.7 With multiple complications
0.000 0.489 0.511
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.489 0.511
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.489 0.511
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.489 0.511
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.489 0.511
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.489 0.511
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.489 0.511
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.489 0.511
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.489 0.511
E10.8 With unspecified complications
0.000 0.490 0.510
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.502 0.498
E45 Retarded development following protein-energy malnutrition
0.000 0.502 0.498
E43 Unspecified severe protein-energy malnutrition
0.000 0.502 0.498
E42 Marasmic kwashiorkor
0.000 0.502 0.498
E41 Nutritional marasmus
0.000 0.502 0.498
E40 Kwashiorkor
0.000 0.502 0.498
E07.8 Other specified disorders of thyroid
0.000 0.504 0.496
E14.2 Withrenal complications
0.000 0.511 0.488
E06.9 Thyroiditis, unspecified
0.000 0.516 0.484
E14.5 With peripheral circulatory complications
0.000 0.517 0.483
E14.0 With coma
0.000 0.521 0.479
E46 Unspecified protein-energy malnutrition
0.000 0.521 0.479
E03 Other hypothyroidism
0.000 0.546 0.454
E06.1 Subacute thyroiditis
0.000 0.551 0.449
E07.1 Dyshormogenetic goitre
0.000 0.551 0.449
E07.0 Hypersecretion of calcitonin
0.000 0.551 0.449
E06.4 Drug-induced thyroiditis
0.000 0.572 0.428
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.572 0.428
E06.0 Acute thyroiditis
0.000 0.572 0.428
E06.5 Other chronic thyroiditis
0.000 0.589 0.411
K90 Intestinal malabsorption
0.000 0.602 0.398
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.001 0.611 0.388
E44.1 Mild protein-energy malnutrition
0.000 0.642 0.357
E44.0 Moderate protein-energy malnutrition
0.000 0.642 0.357
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.660 0.340
E11 Non-insulin-dependent diabetes mellitus
0.000 0.668 0.332
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.669 0.331
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.674 0.326
E03.5 Myxoedema coma
0.000 0.675 0.325
E03.4 Atrophy of thyroid (acquired)
0.000 0.675 0.325
E03.3 Postinfectious hypothyroidism
0.000 0.675 0.325
E65-E68 Obesity and other hyperalimentation
0.000 0.675 0.325
E50-E64 Other nutritional deficiencies
0.000 0.676 0.324
E03.1 Congenital hypothyroidism without goitre
0.000 0.687 0.313
E11.6 With other specified complications
0.000 0.698 0.302
E11.1 With ketoacidosis
0.000 0.708 0.292
K90.3 Pancreatic steatorrhoea
0.000 0.715 0.285
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.715 0.285
K90.1 Tropical sprue
0.000 0.715 0.285
E03.8 Other specified hypothyroidism
0.000 0.722 0.278
K90.8 Other intestinal malabsorption
0.000 0.727 0.273
E11.0 With coma
0.000 0.732 0.268
E07.9 Disorder of thyroid, unspecified
0.000 0.736 0.264
E11.2 With renal complications
0.000 0.750 0.250
E70-E90 Metabolic disorders
0.001 0.754 0.245
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.759 0.241
E11.7 With multiple complications
0.000 0.762 0.238
E54 Ascorbic acid deficiency
0.000 0.764 0.236
E78.2 Mixed hyperlipidaemia
0.000 0.766 0.234
E67 Other hyperalimentation
0.000 0.767 0.233
E68 Sequelae of hyperalimentation
0.000 0.767 0.233
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.767 0.233
E63 Other nutritional deficiencies
0.000 0.767 0.233
E50 Vitamin A deficiency
0.000 0.767 0.233
E60 Dietary zinc deficiency
0.000 0.767 0.233
E59 Dietary selenium deficiency
0.000 0.767 0.233
E52 Niacin deficiency [pellagra]
0.000 0.767 0.233
E51 Thiamine deficiency
0.000 0.769 0.231
E83 Disorders of mineral metabolism
0.160 0.780 0.060
E56 Other vitamin deficiencies
0.000 0.780 0.219
E78.5 Hyperlipidaemia, unspecified
0.000 0.785 0.215
E78.1 Pure hyperglyceridaemia
0.000 0.789 0.211
E55 Vitamin D deficiency
0.000 0.791 0.209
M45.X9 Ankylosing spondylitis (Site unspecified)
0.209 0.791 0.000
E58 Dietary calcium deficiency
0.000 0.798 0.202
K90.9 Intestinal malabsorption, unspecified
0.000 0.801 0.199
E88 Other metabolic disorders
0.000 0.802 0.198
E78.6 Lipoprotein deficiency
0.000 0.806 0.194
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.001 0.808 0.192
E74 Other disorders of carbohydrate metabolism
0.001 0.811 0.188
E11.8 With unspecified complications
0.000 0.813 0.187
E78.3 Hyperchylomicronaemia
0.000 0.818 0.182
E61 Deficiency of other nutrient elements
0.000 0.820 0.180
E84 Cystic fibrosis
0.001 0.822 0.177
E85 Amyloidosis
0.001 0.823 0.177
E77 Disorders of glycoprotein metabolism
0.001 0.824 0.176
E76 Disorders of glycosaminoglycan metabolism
0.001 0.824 0.176
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.001 0.824 0.176
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.001 0.824 0.176
E65 Localised adiposity
0.000 0.824 0.176
E73 Lactose intolerance
0.001 0.825 0.175
E88.9 Metabolic disorder, unspecified
0.000 0.829 0.171
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.830 0.170
E67.8 Other specified hyperalimentation
0.000 0.832 0.167
E67.3 Hypervitaminosis D
0.000 0.832 0.167
E67.2 Megavitamin-B6 syndrome
0.000 0.832 0.167
E67.1 Hypercarotenaemia
0.000 0.832 0.167
E67.0 Hypervitaminosis A
0.000 0.832 0.167
E70 Disorders of aromatic amino-acid metabolism
0.001 0.833 0.167
E50.9 Vitamin A deficiency, unspecified
0.000 0.833 0.167
E50.8 Other manifestations of vitamin A deficiency
0.000 0.833 0.167
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.833 0.167
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.833 0.167
E50.5 Vitamin A deficiency with night blindness
0.000 0.833 0.167
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.833 0.167
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.833 0.167
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.833 0.167
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.833 0.167
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.833 0.167
E63.9 Nutritional deficiency, unspecified
0.000 0.833 0.167
E63.8 Other specified nutritional deficiencies
0.000 0.833 0.167
E63.1 Imbalance of constituents of food intake
0.000 0.833 0.167
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.833 0.167
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.833 0.167
E64.8 Sequelae of other nutritional deficiencies
0.000 0.833 0.167
E64.3 Sequelae of rickets
0.000 0.833 0.167
E64.2 Sequelae of vitamin C deficiency
0.000 0.833 0.167
E64.1 Sequelae of vitamin A deficiency
0.000 0.833 0.167
E64.0 Sequelae of protein-energy malnutrition
0.000 0.833 0.167
E51.9 Thiamine deficiency, unspecified
0.000 0.834 0.166
E51.8 Other manifestations of thiamine deficiency
0.000 0.834 0.166
E51.1 Beriberi
0.000 0.834 0.166
E51.2 Wernicke's encephalopathy
0.000 0.835 0.165
E79 Disorders of purine and pyrimidine metabolism
0.001 0.835 0.164
E14.9 Without complications
0.000 0.836 0.164
E72 Other disorders of amino-acid metabolism
0.001 0.840 0.160
E03.9 Hypothyroidism, unspecified
0.000 0.840 0.160
E53 Deficiency of other B group vitamins
0.000 0.842 0.158
E83.8 Other disorders of mineral metabolism
0.115 0.842 0.043
E83.2 Disorders of zinc metabolism
0.115 0.842 0.043
E83.0 Disorders of copper metabolism
0.115 0.842 0.043
E56.9 Vitamin deficiency, unspecified
0.000 0.842 0.157
E56.8 Deficiency of other vitamins
0.000 0.842 0.157
E56.0 Deficiency of vitamin E
0.000 0.842 0.157
E20-E35 Disorders of other endocrine glands
0.000 0.843 0.157
E83.9 Disorder of mineral metabolism, unspecified
0.114 0.844 0.042
E06.3 Autoimmune thyroiditis
0.001 0.844 0.156
I73.9 Peripheral vascular disease, unspecified
0.000 0.844 0.156
E88.2 Lipomatosis, not elsewhere classified
0.000 0.844 0.156
I73 Other peripheral vascular diseases
0.000 0.844 0.156
I83 Varicose veins of lower extremities
0.156 0.844 0.000
E78.4 Other hyperlipidaemia
0.000 0.845 0.155
I77 Other disorders of arteries and arterioles
0.000 0.845 0.155
I70-I79 Diseases of arteries, arterioles and capillaries
0.000 0.846 0.154
E75.5 Other lipid storage disorders
0.000 0.847 0.152
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.848 0.152
E55.0 Rickets, active
0.000 0.850 0.150
E74.3 Other disorders of intestinal carbohydrate absorption
0.000 0.850 0.150
E83.3 Disorders of phosphorus metabolism
0.133 0.851 0.016
I77.6 Arteritis, unspecified
0.000 0.853 0.147
E85.4 Organ-limited amyloidosis
0.000 0.854 0.146
E11.5 With peripheral circulatory complications
0.000 0.855 0.145
E56.1 Deficiency of vitamin K
0.000 0.855 0.144
I74 Arterial embolism and thrombosis
0.000 0.856 0.144
I77.9 Disorder of arteries and arterioles, unspecified
0.000 0.857 0.143
E24 Cushing's syndrome
0.000 0.858 0.142
E75.2 Other sphingolipidosis
0.001 0.860 0.140
I72 Other aneurysm
0.000 0.861 0.139
E75.6 Lipid storage disorder, unspecified
0.001 0.862 0.138
E75.4 Neuronal ceroid lipofuscinosis
0.001 0.862 0.138
E75.3 Sphingolipidosis, unspecified
0.001 0.862 0.138
E75.1 Other gangliosidosis
0.001 0.862 0.138
E75.0 GM2 gangliosidosis
0.001 0.862 0.138
E74.9 Disorder of carbohydrate metabolism, unspecified
0.001 0.865 0.135
E74.8 Other specified disorders of carbohydrate metabolism
0.001 0.865 0.135
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.001 0.865 0.135
E74.2 Disorders of galactose metabolism
0.001 0.865 0.135
E74.1 Disorders of fructose metabolism
0.001 0.865 0.135
I74.5 Embolism and thrombosis of iliac artery
0.000 0.865 0.135
E88.8 Other specified metabolic disorders
0.000 0.866 0.134
I74.3 Embolism and thrombosis of arteries of the lower extremities
0.000 0.866 0.134
I77.8 Other specified disorders of arteries and arterioles
0.000 0.867 0.133
E85.3 Secondary systemic amyloidosis
0.000 0.867 0.133
I73.0 Raynaud's syndrome
0.000 0.867 0.133
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.868 0.132
E74.0 Glycogen storage disease
0.001 0.868 0.131
E84.0 Cystic fibrosis with pulmonary manifestations
0.001 0.869 0.130
E61.9 Deficiency of nutrient element, unspecified
0.000 0.870 0.129
E61.8 Deficiency of other specified nutrient elements
0.000 0.870 0.129
E61.7 Deficiency of multiple nutrient elements
0.000 0.870 0.129
E61.6 Vanadium deficiency
0.000 0.870 0.129
E61.5 Molybdenum deficiency
0.000 0.870 0.129
E61.4 Chromium deficiency
0.000 0.870 0.129
E61.3 Manganese deficiency
0.000 0.870 0.129
E61.0 Copper deficiency
0.000 0.870 0.129
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.871 0.129
E85.8 Other amyloidosis
0.001 0.872 0.128
E84.8 Cystic fibrosis with other manifestations
0.001 0.872 0.127
E84.1 Cystic fibrosis with intestinal manifestations
0.001 0.872 0.127
E85.2 Heredofamilial amyloidosis, unspecified
0.001 0.873 0.127
E85.1 Neuropathic heredofamilial amyloidosis
0.001 0.873 0.127
E85.0 Nonneuropathic heredofamilial amyloidosis
0.001 0.873 0.127
E55.9 Vitamin D deficiency, unspecified
0.000 0.873 0.127
E84.9 Cystic fibrosis, unspecified
0.001 0.873 0.126
E71.3 Disorders of fatty-acid metabolism
0.001 0.873 0.126
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.001 0.873 0.126
E71.1 Other disorders of branched-chain amino-acid metabolism
0.001 0.873 0.126
E71.0 Maple-syrup-urine disease
0.001 0.873 0.126
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.001 0.873 0.126
E76.8 Other disorders of glucosaminoglycan metabolism
0.001 0.873 0.126
E76.3 Mucopolysaccharidosis, unspecified
0.001 0.873 0.126
E76.2 Other mucopolysaccharidoses
0.001 0.873 0.126
E76.1 Mucopolysaccharidosis, type II
0.001 0.873 0.126
E76.0 Mucopolysaccharidosis, type I
0.001 0.873 0.126
E77.9 Disorder of glycoprotein metabolism, unspecified
0.001 0.873 0.126
E77.8 Other disorders of glycoprotein metabolism
0.001 0.873 0.126
E77.1 Defects in glycoprotein degradation
0.001 0.873 0.126
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.001 0.873 0.126
E73.8 Other lactose intolerance
0.001 0.874 0.125
E73.1 Secondary lactase deficiency
0.001 0.874 0.125
E73.0 Congenital lactase deficiency
0.001 0.874 0.125
E73.9 Lactose intolerance, unspecified
0.000 0.875 0.124
I70 Atherosclerosis
0.000 0.877 0.123
I77.1 Stricture of artery
0.000 0.877 0.123
I74.4 Embolism and thrombosis of arteries of extremities, unspecified
0.000 0.878 0.122
E24.9 Cushing's syndrome, unspecified
0.000 0.878 0.122
E21.3 Hyperparathyroidism, unspecified
0.000 0.878 0.122
E78.0 Pure hypercholesterolaemia
0.000 0.879 0.121
I72.4 Aneurysm of artery of lower extremity
0.000 0.880 0.120
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.001 0.880 0.120
E70.8 Other disorders of aromatic amino-acid metabolism
0.001 0.880 0.120
E70.2 Disorders of tyrosine metabolism
0.001 0.880 0.120
E70.1 Other hyperphenylalaninaemias
0.001 0.880 0.120
E70.0 Classical phenylketonuria
0.001 0.880 0.120
I73.8 Other specified peripheral vascular diseases
0.000 0.881 0.119
E24.0 Pituitary-dependent Cushing's disease
0.000 0.882 0.118
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.001 0.882 0.117
E79.8 Other disorders of purine and pyrimidine metabolism
0.001 0.882 0.117
E79.1 Lesch-Nyhan syndrome
0.001 0.882 0.117
E20 Hypoparathyroidism
0.000 0.882 0.117
I77.3 Arterial fibromuscular dysplasia
0.000 0.883 0.117
E88.3 Tumour lysis syndrome
0.000 0.883 0.117
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.000 0.883 0.117
E53.9 Vitamin B deficiency, unspecified
0.000 0.883 0.117
I72.3 Aneurysm of iliac artery
0.000 0.884 0.116
E72.9 Disorder of amino-acid metabolism, unspecified
0.001 0.885 0.115
E72.8 Other specified disorders of amino-acid metabolism
0.001 0.885 0.115
E72.5 Disorders of glycine metabolism
0.001 0.885 0.115
E72.4 Disorders of ornithine metabolism
0.001 0.885 0.115
E72.3 Disorders of lysine and hydroxylysine metabolism
0.001 0.885 0.115
E72.2 Disorders of urea cycle metabolism
0.001 0.885 0.115
E61.2 Magnesium deficiency
0.000 0.886 0.114
E53.1 Pyridoxine deficiency
0.000 0.886 0.114
E53.0 Riboflavin deficiency
0.000 0.886 0.114
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.887 0.112
E32 Diseases of thymus
0.000 0.887 0.112
E30 Disorders of puberty, not elsewhere classified
0.000 0.887 0.112
I77.2 Rupture of artery
0.000 0.888 0.112
E72.0 Disorders of amino-acid transport
0.001 0.888 0.111
E25 Adrenogenital disorders
0.000 0.888 0.112
I77.5 Necrosis of artery
0.000 0.889 0.111
I77.4 Coeliac artery compression syndrome
0.000 0.889 0.111
E70.3 Albinism
0.001 0.889 0.111
E78.8 Other disorders of lipoprotein metabolism
0.000 0.889 0.111
E31 Polyglandular dysfunction
0.000 0.890 0.110
I74.2 Embolism and thrombosis of arteries of the upper extremities
0.000 0.890 0.110
I72.0 Aneurysm of carotid artery
0.000 0.891 0.109
E11.3 With ophthalmic complications
0.000 0.892 0.108
I72.1 Aneurysm of artery of upper extremity
0.000 0.892 0.108
E24.2 Drug-induced Cushing's syndrome
0.000 0.893 0.107
M45 Ankylosing spondylitis
0.107 0.893 0.000
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.001 0.894 0.106
E28 Ovarian dysfunction
0.000 0.894 0.106
I83.0 Varicose veins of lower extremities with ulcer
0.105 0.895 0.000
I73.1 Thromboangiitis obliterans [Buerger]
0.000 0.896 0.103
I74.0 Embolism and thrombosis of abdominal aorta
0.000 0.896 0.103
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.001 0.896 0.103
E24.8 Other Cushing's syndrome
0.000 0.898 0.102
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.898 0.102
E24.3 Ectopic ACTH syndrome
0.000 0.898 0.102
E24.1 Nelson's syndrome
0.000 0.898 0.102
E61.1 Iron deficiency
0.000 0.899 0.101
I72.6 Aneurysm and dissection of vertebral artery
0.000 0.900 0.100
I72.5 Aneurysm and dissection of other precerebral arteries
0.000 0.900 0.100
I72.9 Aneurysm of unspecified site
0.000 0.902 0.098
I70.2 Atherosclerosis of arteries of the extremities
0.000 0.902 0.098
E29 Testicular dysfunction
0.000 0.903 0.097
E80 Disorders of porphyrin and bilirubin metabolism
0.001 0.903 0.097
I83.2 Varicose veins of lower extremities with both ulcer and inflammation
0.096 0.903 0.000
I70.8 Atherosclerosis of other arteries
0.000 0.907 0.093
E21.2 Other hyperparathyroidism
0.000 0.907 0.093
E21.4 Other specified disorders of parathyroid gland
0.000 0.908 0.092
I70.1 Atherosclerosis of renal artery
0.000 0.908 0.092
I72.2 Aneurysm of renal artery
0.000 0.909 0.091
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.909 0.090
E20.9 Hypoparathyroidism, unspecified
0.000 0.910 0.089
I72.8 Aneurysm of other specified arteries
0.000 0.911 0.089
E34 Other endocrine disorders
0.000 0.911 0.088
I79.8 Other disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.000 0.912 0.088
I79.2 Peripheral angiopathy in diseases classified elsewhere
0.000 0.913 0.087
I70.9 Generalised and unspecified atherosclerosis
0.000 0.914 0.086
E85.9 Amyloidosis, unspecified
0.001 0.915 0.084
I70.0 Atherosclerosis of aorta
0.000 0.915 0.085
M45.X2 Ankylosing spondylitis (Cervical region)
0.085 0.915 0.000
E20.8 Other hypoparathyroidism
0.000 0.915 0.084
E20.1 Pseudohypoparathyroidism
0.000 0.915 0.084
E20.0 Idiopathic hypoparathyroidism
0.000 0.915 0.084
I79.1 Aortitis in diseases classified elsewhere
0.000 0.916 0.084
I79.0 Aneurysm of aorta in diseases classified elsewhere
0.000 0.916 0.084
I74.1 Embolism and thrombosis of other and unspecified parts of aorta
0.000 0.916 0.084
M45.X6 Ankylosing spondylitis (Lumbar region)
0.083 0.917 0.000
E30.9 Disorder of puberty, unspecified
0.000 0.919 0.081
E30.8 Other disorders of puberty
0.000 0.919 0.081
E30.1 Precocious puberty
0.000 0.919 0.081
E30.0 Delayed puberty
0.000 0.919 0.081
E32.9 Disease of thymus, unspecified
0.000 0.919 0.081
E32.8 Other diseases of thymus
0.000 0.919 0.081
E32.1 Abscess of thymus
0.000 0.919 0.081
E32.0 Persistent hyperplasia of thymus
0.000 0.919 0.081
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.919 0.081
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.919 0.081
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.919 0.081
E25.9 Adrenogenital disorder, unspecified
0.000 0.919 0.080
E25.8 Other adrenogenital disorders
0.000 0.919 0.080
C19 Malignant neoplasm of rectosigmoid junction
0.000 0.920 0.080
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.920 0.080
I70.21 Atherosclerosis of arteries of extremities (with gangrene)
0.000 0.920 0.080
E31.9 Polyglandular dysfunction, unspecified
0.000 0.921 0.079
E31.8 Other polyglandular dysfunction
0.000 0.921 0.079
E31.1 Polyglandular hyperfunction
0.000 0.921 0.079
E83.4 Disorders of magnesium metabolism
0.049 0.922 0.029
E31.0 Autoimmune polyglandular failure
0.000 0.923 0.077
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)
0.077 0.923 0.000
M45.X7 Ankylosing spondylitis (Lumbosacral region)
0.077 0.923 0.000
M45.X5 Ankylosing spondylitis (Thoracolumbar region)
0.077 0.923 0.000
M45.X4 Ankylosing spondylitis (Thoracic region)
0.077 0.923 0.000
M45.X3 Ankylosing spondylitis (Cervicothoracic region)
0.077 0.923 0.000
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)
0.077 0.923 0.000
E11.4 With neurological complications
0.000 0.924 0.076
E28.9 Ovarian dysfunction, unspecified
0.000 0.924 0.076
E28.8 Other ovarian dysfunction
0.000 0.924 0.076
E28.1 Androgen excess
0.000 0.924 0.076
E28.0 Oestrogen excess
0.000 0.924 0.076
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.925 0.075
E80.2 Other porphyria
0.001 0.926 0.074
E26 Hyperaldosteronism
0.000 0.926 0.073
E28.2 Polycystic ovarian syndrome
0.000 0.926 0.074
E28.3 Primary ovarian failure
0.000 0.928 0.072
I70.80 Atherosclerosis of other arteries (without gangrene)
0.000 0.928 0.072
I70.20 Atherosclerosis of arteries of extremities (without gangrene)
0.000 0.928 0.072
E29.9 Testicular dysfunction, unspecified
0.000 0.929 0.071
I78 Diseases of capillaries
0.000 0.929 0.071
E29.8 Other testicular dysfunction
0.000 0.930 0.070
E29.0 Testicular hyperfunction
0.000 0.930 0.070
E80.7 Disorder of bilirubin metabolism, unspecified
0.001 0.930 0.069
E80.5 Crigler-Najjar syndrome
0.001 0.930 0.069
E80.3 Defects of catalase and peroxydase
0.001 0.930 0.069
E80.0 Hereditary erythropoietic porphyria
0.001 0.930 0.069
I70.10 Atherosclerosis of renal artery (without gangrene)
0.000 0.931 0.069
I77.0 Arteriovenous fistula, acquired
0.000 0.932 0.068
I70.81 Atherosclerosis of other arteries (with gangrene)
0.000 0.933 0.067
E21.0 Primary hyperparathyroidism
0.000 0.934 0.066
I70.11 Atherosclerosis of renal artery (with gangrene)
0.000 0.934 0.066
E34.3 Short stature, not elsewhere classified
0.000 0.935 0.064
E34.5 Androgen resistance syndrome
0.000 0.936 0.064
E34.4 Constitutional tall stature
0.000 0.936 0.064
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.936 0.064
E34.1 Other hypersecretion of intestinal hormones
0.000 0.936 0.064
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.063 0.937 0.000
I70.91 Generalized and unspecified atherosclerosis (with gangrene)
0.000 0.938 0.062
E22 Hyperfunction of pituitary gland
0.000 0.938 0.062
I70.01 Atherosclerosis of aorta (with gangrene)
0.000 0.939 0.061
I78.0 Hereditary haemorrhagic telangiectasia
0.000 0.939 0.061
E34.8 Other specified endocrine disorders
0.000 0.940 0.059
I70.90 Generalized and unspecified atherosclerosis (without gangrene)
0.000 0.940 0.059
E80.6 Other disorders of bilirubin metabolism
0.001 0.940 0.059
I74.8 Embolism and thrombosis of other arteries
0.000 0.941 0.059
I74.9 Embolism and thrombosis of unspecified artery
0.000 0.941 0.058
E34.9 Endocrine disorder, unspecified
0.000 0.942 0.058
E80.1 Porphyria cutanea tarda
0.001 0.942 0.057
I70.00 Atherosclerosis of aorta (without gangrene)
0.000 0.942 0.058
E23 Hypofunction and other disorders of pituitary gland
0.000 0.945 0.055
E29.1 Testicular hypofunction
0.000 0.947 0.053
E26.8 Other hyperaldosteronism
0.000 0.947 0.053
E26.1 Secondary hyperaldosteronism
0.000 0.947 0.053
E34.0 Carcinoid syndrome
0.000 0.947 0.053
I83.1 Varicose veins of lower extremities with inflammation
0.051 0.948 0.000
E83.5 Disorders of calcium metabolism
0.006 0.951 0.044
E23.7 Disorder of pituitary gland, unspecified
0.000 0.952 0.048
E26.9 Hyperaldosteronism, unspecified
0.001 0.953 0.046
I78.8 Other diseases of capillaries
0.000 0.953 0.047
I80-I89 Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified
0.046 0.954 0.000
E04 Other non-toxic goitre
0.002 0.955 0.043
E22.8 Other hyperfunction of pituitary gland
0.000 0.955 0.044
E22.1 Hyperprolactinaemia
0.000 0.958 0.042
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.958 0.042
I89 Other non-infective disorders of lymphatic vessels and lymph nodes
0.042 0.958 0.000
I86 Varicose veins of other sites
0.042 0.958 0.000
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.960 0.039
E23.1 Drug-induced hypopituitarism
0.000 0.960 0.039
I78.9 Disease of capillaries, unspecified
0.000 0.961 0.039
I89.0 Lymphoedema, not elsewhere classified
0.038 0.962 0.000
I86.8 Varicose veins of other specified sites
0.038 0.962 0.000
I89.9 Non-infective disorder of lymphatic vessels and lymph nodes, unspecified
0.038 0.962 0.000
I81 Portal vein thrombosis
0.037 0.963 0.000
I86.4 Gastric varices
0.037 0.963 0.000
E80.4 Gilbert's syndrome
0.000 0.966 0.033
I85 Oesophageal varices
0.034 0.966 0.000
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.967 0.033
E04.8 Other specified non-toxic goitre
0.001 0.968 0.031
I89.1 Lymphangitis
0.031 0.968 0.000
I82 Other venous embolism and thrombosis
0.031 0.969 0.000
I86.3 Vulval varices
0.031 0.969 0.000
E53.8 Deficiency of other specified B group vitamins
0.000 0.969 0.031
I86.2 Pelvic varices
0.031 0.969 0.000
E22.0 Acromegaly and pituitary gigantism
0.000 0.970 0.030
I86.0 Sublingual varices
0.030 0.970 0.000
E26.0 Primary hyperaldosteronism
0.001 0.971 0.028
E66 Obesity
0.000 0.972 0.028
S02.40 Fracture of malar and maxillary bones (closed)
0.000 0.972 0.028
I85.9 Oesophageal varices without bleeding
0.028 0.972 0.000
E23.6 Other disorders of pituitary gland
0.000 0.973 0.026
I88 Nonspecific lymphadenitis
0.026 0.973 0.000
I82.8 Embolism and thrombosis of other specified veins
0.026 0.974 0.000
I87 Other disorders of veins
0.026 0.974 0.000
E11.9 Without complications
0.000 0.975 0.025
M45-M49 Spondylopathies
0.025 0.975 0.000
K90-K93 Other diseases of the digestive system
0.000 0.975 0.024
I82.0 Budd-Chiari syndrome
0.024 0.976 0.000
E23.2 Diabetes insipidus
0.000 0.977 0.023
R31 Unspecified haematuria
0.023 0.977 0.000
E04.0 Non-toxic diffuse goitre
0.002 0.977 0.021
I82.1 Thrombophlebitis migrans
0.023 0.977 0.000
E86 Volume depletion
0.000 0.978 0.022
I82.3 Embolism and thrombosis of renal vein
0.022 0.978 0.000
I82.2 Embolism and thrombosis of vena cava
0.021 0.979 0.000
S02.4 Fracture of malar and maxillary bones
0.000 0.979 0.021
E66.1 Drug-induced obesity
0.000 0.980 0.020
I85.0 Oesophageal varices with bleeding
0.020 0.980 0.000
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.001 0.981 0.018
I87.8 Other specified disorders of veins
0.019 0.981 0.000
I88.1 Chronic lymphadenitis, except mesenteric
0.019 0.981 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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