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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs209128
log Bayes Factor = 53.3765
Chromosome 6   position 28,869,173  (GRCh37) Explore rs209128 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E83.1 Disorders of iron metabolism
1.000 0.000 0.000
K90.0 Coeliac disease
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
E05.9 Thyrotoxicosis, unspecified
0.000 0.001 0.999
E10.9 Without complications
0.000 0.001 0.999
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.003 0.997
E16.2 Hypoglycaemia, unspecified
0.000 0.003 0.997
E10-E14 Diabetes mellitus
0.000 0.004 0.996
E10.3 With ophthalmic complications
0.000 0.004 0.996
E16 Other disorders of pancreatic internal secretion
0.000 0.004 0.996
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.004 0.996
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.005 0.995
E00-E07 Disorders of thyroid gland
0.000 0.007 0.993
E10.2 With renal complications
0.000 0.048 0.952
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.059 0.941
E10.1 With ketoacidosis
0.000 0.068 0.932
E10.4 With neurological complications
0.000 0.092 0.908
I83.9 Varicose veins of lower extremities without ulcer or inflammation
0.862 0.138 0.000
E05.8 Other thyrotoxicosis
0.000 0.188 0.812
E16.1 Other hypoglycaemia
0.000 0.196 0.804
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.212 0.788
E13 Other specified diabetes mellitus
0.000 0.217 0.783
E10.7 With multiple complications
0.000 0.251 0.749
E10.0 With coma
0.000 0.280 0.720
E05.5 Thyroid crisis or storm
0.000 0.285 0.715
E05.4 Thyrotoxicosis factitia
0.000 0.285 0.715
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.285 0.715
E12 Malnutrition-related diabetes mellitus
0.000 0.285 0.714
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.286 0.714
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.286 0.714
E16.4 Abnormal secretion of gastrin
0.000 0.286 0.714
E16.3 Increased secretion of glucagon
0.000 0.286 0.714
E15 Nondiabetic hypoglycaemic coma
0.000 0.286 0.714
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.288 0.712
E00 Congenital iodine-deficiency syndrome
0.000 0.288 0.712
E40-E46 Malnutrition
0.000 0.315 0.685
E14 Unspecified diabetes mellitus
0.000 0.320 0.680
E10.5 With peripheral circulatory complications
0.000 0.330 0.670
E10.6 With other specified complications
0.000 0.333 0.667
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.364 0.635
E13.9 Without complications
0.000 0.373 0.627
E07 Other disorders of thyroid
0.000 0.399 0.601
E06 Thyroiditis
0.000 0.415 0.585
E14.3 With ophthalmic complications
0.000 0.427 0.573
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.427 0.572
E13.3 With ophthalmic complications
0.000 0.435 0.565
E13.8 With unspecified complications
0.000 0.439 0.561
E13.7 With multiple complications
0.000 0.439 0.561
E13.6 With other specified complications
0.000 0.439 0.561
E13.5 With peripheral circulatory complications
0.000 0.439 0.561
E13.4 With neurological complications
0.000 0.439 0.561
E13.2 With renal complications
0.000 0.439 0.561
E13.1 With ketoacidosis
0.000 0.439 0.561
E13.0 With coma
0.000 0.439 0.561
E14.1 With ketoacidosis
0.000 0.452 0.548
E14.6 With other specified complications
0.000 0.484 0.516
E12.9 Without complications
0.000 0.488 0.512
E12.8 With unspecified complications
0.000 0.488 0.512
E12.7 With multiple complications
0.000 0.488 0.512
E12.6 With other specified complications
0.000 0.488 0.512
E12.5 With peripheral circulatory complications
0.000 0.488 0.512
E12.4 With neurological complications
0.000 0.488 0.512
E12.3 With ophthalmic complications
0.000 0.488 0.512
E12.2 With renal complications
0.000 0.488 0.512
E12.1 With ketoacidosis
0.000 0.488 0.512
E12.0 With coma
0.000 0.488 0.512
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.489 0.510
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.489 0.510
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.489 0.510
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.489 0.510
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.489 0.510
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.489 0.510
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.489 0.510
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.489 0.510
E10.8 With unspecified complications
0.000 0.494 0.506
E14.4 With neurological complications
0.000 0.494 0.505
E14.8 With unspecified complications
0.000 0.507 0.493
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.509 0.491
E45 Retarded development following protein-energy malnutrition
0.000 0.509 0.491
E43 Unspecified severe protein-energy malnutrition
0.000 0.509 0.491
E42 Marasmic kwashiorkor
0.000 0.509 0.491
E41 Nutritional marasmus
0.000 0.509 0.491
E40 Kwashiorkor
0.000 0.509 0.491
E14.7 With multiple complications
0.000 0.512 0.488
E07.8 Other specified disorders of thyroid
0.000 0.526 0.474
E06.9 Thyroiditis, unspecified
0.000 0.529 0.471
E14.2 Withrenal complications
0.000 0.535 0.465
E46 Unspecified protein-energy malnutrition
0.000 0.537 0.463
E14.5 With peripheral circulatory complications
0.000 0.540 0.460
E14.0 With coma
0.000 0.544 0.456
E06.1 Subacute thyroiditis
0.000 0.561 0.439
E03 Other hypothyroidism
0.000 0.569 0.431
E07.1 Dyshormogenetic goitre
0.000 0.569 0.431
E07.0 Hypersecretion of calcitonin
0.000 0.569 0.431
E06.4 Drug-induced thyroiditis
0.000 0.581 0.419
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.581 0.419
E06.0 Acute thyroiditis
0.000 0.581 0.419
K90 Intestinal malabsorption
0.000 0.590 0.410
E06.5 Other chronic thyroiditis
0.000 0.598 0.402
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.001 0.619 0.381
E44.1 Mild protein-energy malnutrition
0.000 0.647 0.352
E44.0 Moderate protein-energy malnutrition
0.000 0.647 0.352
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.652 0.348
E11 Non-insulin-dependent diabetes mellitus
0.000 0.658 0.342
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.677 0.323
E65-E68 Obesity and other hyperalimentation
0.000 0.678 0.322
E50-E64 Other nutritional deficiencies
0.000 0.686 0.314
E11.6 With other specified complications
0.000 0.690 0.310
E03.5 Myxoedema coma
0.000 0.691 0.309
E03.4 Atrophy of thyroid (acquired)
0.000 0.691 0.309
E03.3 Postinfectious hypothyroidism
0.000 0.691 0.309
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.691 0.309
E11.1 With ketoacidosis
0.000 0.701 0.299
E03.1 Congenital hypothyroidism without goitre
0.000 0.703 0.297
K90.3 Pancreatic steatorrhoea
0.000 0.706 0.294
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.706 0.294
K90.1 Tropical sprue
0.000 0.706 0.294
E11.0 With coma
0.000 0.717 0.282
K90.8 Other intestinal malabsorption
0.000 0.719 0.281
E03.8 Other specified hypothyroidism
0.000 0.739 0.261
E11.2 With renal complications
0.000 0.739 0.261
M45.X9 Ankylosing spondylitis (Site unspecified)
0.252 0.748 0.000
E11.7 With multiple complications
0.000 0.755 0.245
E67 Other hyperalimentation
0.000 0.769 0.231
E68 Sequelae of hyperalimentation
0.000 0.769 0.231
E54 Ascorbic acid deficiency
0.000 0.771 0.228
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.775 0.225
E63 Other nutritional deficiencies
0.000 0.775 0.225
E50 Vitamin A deficiency
0.000 0.775 0.225
E60 Dietary zinc deficiency
0.000 0.775 0.225
E59 Dietary selenium deficiency
0.000 0.775 0.225
E52 Niacin deficiency [pellagra]
0.000 0.775 0.225
E07.9 Disorder of thyroid, unspecified
0.000 0.776 0.224
E51 Thiamine deficiency
0.000 0.776 0.223
E56 Other vitamin deficiencies
0.000 0.788 0.212
E55 Vitamin D deficiency
0.000 0.798 0.202
E11.8 With unspecified complications
0.000 0.799 0.201
K90.9 Intestinal malabsorption, unspecified
0.000 0.801 0.199
E58 Dietary calcium deficiency
0.000 0.805 0.195
I83 Varicose veins of lower extremities
0.188 0.812 0.000
E83 Disorders of mineral metabolism
0.155 0.818 0.027
E65 Localised adiposity
0.000 0.828 0.172
E61 Deficiency of other nutrient elements
0.000 0.829 0.171
E67.8 Other specified hyperalimentation
0.000 0.834 0.166
E67.3 Hypervitaminosis D
0.000 0.834 0.166
E67.2 Megavitamin-B6 syndrome
0.000 0.834 0.166
E67.1 Hypercarotenaemia
0.000 0.834 0.166
E67.0 Hypervitaminosis A
0.000 0.834 0.166
E50.9 Vitamin A deficiency, unspecified
0.000 0.838 0.161
E50.8 Other manifestations of vitamin A deficiency
0.000 0.838 0.161
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.838 0.161
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.838 0.161
E50.5 Vitamin A deficiency with night blindness
0.000 0.838 0.161
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.838 0.161
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.838 0.161
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.838 0.161
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.838 0.161
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.838 0.161
E63.9 Nutritional deficiency, unspecified
0.000 0.838 0.161
E63.8 Other specified nutritional deficiencies
0.000 0.838 0.161
E63.1 Imbalance of constituents of food intake
0.000 0.838 0.161
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.838 0.161
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.838 0.161
E64.8 Sequelae of other nutritional deficiencies
0.000 0.838 0.161
E64.3 Sequelae of rickets
0.000 0.838 0.161
E64.2 Sequelae of vitamin C deficiency
0.000 0.838 0.161
E64.1 Sequelae of vitamin A deficiency
0.000 0.838 0.161
E64.0 Sequelae of protein-energy malnutrition
0.000 0.838 0.161
E51.9 Thiamine deficiency, unspecified
0.000 0.839 0.160
E51.8 Other manifestations of thiamine deficiency
0.000 0.839 0.160
E51.1 Beriberi
0.000 0.839 0.160
E51.2 Wernicke's encephalopathy
0.000 0.841 0.159
E53 Deficiency of other B group vitamins
0.000 0.847 0.153
E56.9 Vitamin deficiency, unspecified
0.000 0.848 0.152
E56.8 Deficiency of other vitamins
0.000 0.848 0.152
E56.0 Deficiency of vitamin E
0.000 0.848 0.152
E14.9 Without complications
0.000 0.849 0.151
E11.5 With peripheral circulatory complications
0.000 0.850 0.150
E06.3 Autoimmune thyroiditis
0.001 0.854 0.146
E55.0 Rickets, active
0.000 0.855 0.145
E20-E35 Disorders of other endocrine glands
0.000 0.856 0.144
E56.1 Deficiency of vitamin K
0.000 0.860 0.139
E03.9 Hypothyroidism, unspecified
0.000 0.862 0.138
E83.3 Disorders of phosphorus metabolism
0.131 0.862 0.007
I83.0 Varicose veins of lower extremities with ulcer
0.134 0.865 0.000
C19 Malignant neoplasm of rectosigmoid junction
0.000 0.866 0.134
E83.8 Other disorders of mineral metabolism
0.111 0.870 0.019
E83.2 Disorders of zinc metabolism
0.111 0.870 0.019
E83.0 Disorders of copper metabolism
0.111 0.870 0.019
E24 Cushing's syndrome
0.000 0.870 0.130
M45 Ankylosing spondylitis
0.130 0.870 0.000
E83.9 Disorder of mineral metabolism, unspecified
0.111 0.870 0.019
E61.9 Deficiency of nutrient element, unspecified
0.000 0.877 0.123
E61.8 Deficiency of other specified nutrient elements
0.000 0.877 0.123
E61.7 Deficiency of multiple nutrient elements
0.000 0.877 0.123
E61.6 Vanadium deficiency
0.000 0.877 0.123
E61.5 Molybdenum deficiency
0.000 0.877 0.123
E61.4 Chromium deficiency
0.000 0.877 0.123
E61.3 Manganese deficiency
0.000 0.877 0.123
E61.0 Copper deficiency
0.000 0.877 0.123
E55.9 Vitamin D deficiency, unspecified
0.000 0.878 0.122
I83.2 Varicose veins of lower extremities with both ulcer and inflammation
0.117 0.882 0.000
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.883 0.117
E53.9 Vitamin B deficiency, unspecified
0.000 0.887 0.112
E24.9 Cushing's syndrome, unspecified
0.000 0.889 0.111
E21.3 Hyperparathyroidism, unspecified
0.000 0.890 0.110
E53.1 Pyridoxine deficiency
0.000 0.890 0.110
E53.0 Riboflavin deficiency
0.000 0.890 0.110
E70-E90 Metabolic disorders
0.001 0.891 0.107
E24.0 Pituitary-dependent Cushing's disease
0.000 0.892 0.108
E61.2 Magnesium deficiency
0.000 0.892 0.108
E20 Hypoparathyroidism
0.000 0.892 0.107
E11.3 With ophthalmic complications
0.000 0.895 0.105
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.896 0.103
E32 Diseases of thymus
0.000 0.896 0.103
E30 Disorders of puberty, not elsewhere classified
0.000 0.896 0.103
E28 Ovarian dysfunction
0.000 0.897 0.103
M45.X2 Ankylosing spondylitis (Cervical region)
0.103 0.897 0.000
E25 Adrenogenital disorders
0.000 0.897 0.103
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.897 0.103
E31 Polyglandular dysfunction
0.000 0.898 0.101
M45.X6 Ankylosing spondylitis (Lumbar region)
0.100 0.899 0.000
E78.2 Mixed hyperlipidaemia
0.000 0.900 0.100
E24.2 Drug-induced Cushing's syndrome
0.000 0.902 0.098
E24.8 Other Cushing's syndrome
0.000 0.906 0.093
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.906 0.093
E24.3 Ectopic ACTH syndrome
0.000 0.906 0.093
E24.1 Nelson's syndrome
0.000 0.906 0.093
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)
0.093 0.906 0.000
M45.X7 Ankylosing spondylitis (Lumbosacral region)
0.093 0.906 0.000
M45.X5 Ankylosing spondylitis (Thoracolumbar region)
0.093 0.906 0.000
M45.X4 Ankylosing spondylitis (Thoracic region)
0.093 0.906 0.000
M45.X3 Ankylosing spondylitis (Cervicothoracic region)
0.093 0.906 0.000
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)
0.093 0.906 0.000
E61.1 Iron deficiency
0.000 0.907 0.092
E78.1 Pure hyperglyceridaemia
0.000 0.910 0.090
E88 Other metabolic disorders
0.000 0.914 0.085
E78.5 Hyperlipidaemia, unspecified
0.000 0.914 0.086
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.001 0.915 0.084
E29 Testicular dysfunction
0.000 0.915 0.085
E21.2 Other hyperparathyroidism
0.000 0.916 0.084
E21.4 Other specified disorders of parathyroid gland
0.000 0.916 0.084
E74 Other disorders of carbohydrate metabolism
0.001 0.917 0.082
E78.6 Lipoprotein deficiency
0.000 0.917 0.083
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.918 0.081
E20.9 Hypoparathyroidism, unspecified
0.000 0.919 0.081
E34 Other endocrine disorders
0.000 0.920 0.080
E84 Cystic fibrosis
0.001 0.921 0.078
E77 Disorders of glycoprotein metabolism
0.001 0.922 0.077
E76 Disorders of glycosaminoglycan metabolism
0.001 0.922 0.077
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.001 0.922 0.077
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.001 0.922 0.077
E28.2 Polycystic ovarian syndrome
0.000 0.922 0.078
E78.3 Hyperchylomicronaemia
0.000 0.922 0.078
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.077 0.923 0.000
E20.8 Other hypoparathyroidism
0.000 0.923 0.077
E20.1 Pseudohypoparathyroidism
0.000 0.923 0.077
E20.0 Idiopathic hypoparathyroidism
0.000 0.923 0.077
E85 Amyloidosis
0.001 0.923 0.077
E73 Lactose intolerance
0.001 0.923 0.076
E11.4 With neurological complications
0.000 0.924 0.076
E30.9 Disorder of puberty, unspecified
0.000 0.926 0.074
E30.8 Other disorders of puberty
0.000 0.926 0.074
E30.1 Precocious puberty
0.000 0.926 0.074
E30.0 Delayed puberty
0.000 0.926 0.074
E32.9 Disease of thymus, unspecified
0.000 0.926 0.074
E32.8 Other diseases of thymus
0.000 0.926 0.074
E32.1 Abscess of thymus
0.000 0.926 0.074
E32.0 Persistent hyperplasia of thymus
0.000 0.926 0.074
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.926 0.074
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.926 0.074
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.926 0.074
E28.9 Ovarian dysfunction, unspecified
0.000 0.926 0.074
E28.8 Other ovarian dysfunction
0.000 0.926 0.074
E28.1 Androgen excess
0.000 0.926 0.074
E28.0 Oestrogen excess
0.000 0.926 0.074
E70 Disorders of aromatic amino-acid metabolism
0.001 0.926 0.073
E88.9 Metabolic disorder, unspecified
0.000 0.926 0.074
E25.9 Adrenogenital disorder, unspecified
0.000 0.926 0.074
E25.8 Other adrenogenital disorders
0.000 0.926 0.074
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.927 0.073
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.927 0.073
E31.9 Polyglandular dysfunction, unspecified
0.000 0.927 0.073
E31.8 Other polyglandular dysfunction
0.000 0.927 0.073
E31.1 Polyglandular hyperfunction
0.000 0.927 0.073
E79 Disorders of purine and pyrimidine metabolism
0.001 0.927 0.072
E72 Other disorders of amino-acid metabolism
0.001 0.929 0.070
E31.0 Autoimmune polyglandular failure
0.000 0.929 0.071
I83.1 Varicose veins of lower extremities with inflammation
0.071 0.929 0.000
E28.3 Primary ovarian failure
0.000 0.930 0.070
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.932 0.068
E26 Hyperaldosteronism
0.000 0.932 0.067
E75.5 Other lipid storage disorders
0.001 0.933 0.067
E88.2 Lipomatosis, not elsewhere classified
0.000 0.933 0.067
E74.3 Other disorders of intestinal carbohydrate absorption
0.001 0.934 0.065
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.934 0.065
E78.4 Other hyperlipidaemia
0.000 0.934 0.065
E85.4 Organ-limited amyloidosis
0.000 0.937 0.063
E83.4 Disorders of magnesium metabolism
0.051 0.937 0.012
E75.2 Other sphingolipidosis
0.001 0.938 0.061
E75.6 Lipid storage disorder, unspecified
0.001 0.939 0.060
E75.4 Neuronal ceroid lipofuscinosis
0.001 0.939 0.060
E75.3 Sphingolipidosis, unspecified
0.001 0.939 0.060
E75.1 Other gangliosidosis
0.001 0.939 0.060
E75.0 GM2 gangliosidosis
0.001 0.939 0.060
E29.8 Other testicular dysfunction
0.000 0.939 0.061
E29.0 Testicular hyperfunction
0.000 0.939 0.061
E74.9 Disorder of carbohydrate metabolism, unspecified
0.001 0.940 0.059
E74.8 Other specified disorders of carbohydrate metabolism
0.001 0.940 0.059
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.001 0.940 0.059
E74.2 Disorders of galactose metabolism
0.001 0.940 0.059
E74.1 Disorders of fructose metabolism
0.001 0.940 0.059
E29.9 Testicular dysfunction, unspecified
0.000 0.940 0.059
C15-C26 Malignant neoplasms of digestive organs
0.000 0.941 0.059
C20 Malignant neoplasm of rectum
0.000 0.942 0.058
E34.3 Short stature, not elsewhere classified
0.000 0.942 0.058
E85.3 Secondary systemic amyloidosis
0.001 0.942 0.057
E74.0 Glycogen storage disease
0.001 0.942 0.057
E88.8 Other specified metabolic disorders
0.000 0.942 0.058
E84.0 Cystic fibrosis with pulmonary manifestations
0.001 0.942 0.057
E34.5 Androgen resistance syndrome
0.000 0.942 0.057
E34.4 Constitutional tall stature
0.000 0.942 0.057
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.942 0.057
E34.1 Other hypersecretion of intestinal hormones
0.000 0.942 0.057
C15 Malignant neoplasm of oesophagus
0.000 0.943 0.057
E84.8 Cystic fibrosis with other manifestations
0.001 0.943 0.056
E84.1 Cystic fibrosis with intestinal manifestations
0.001 0.943 0.056
E71.3 Disorders of fatty-acid metabolism
0.001 0.944 0.055
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.001 0.944 0.055
E71.1 Other disorders of branched-chain amino-acid metabolism
0.001 0.944 0.055
E71.0 Maple-syrup-urine disease
0.001 0.944 0.055
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.001 0.944 0.055
E76.8 Other disorders of glucosaminoglycan metabolism
0.001 0.944 0.055
E76.3 Mucopolysaccharidosis, unspecified
0.001 0.944 0.055
E76.2 Other mucopolysaccharidoses
0.001 0.944 0.055
E76.1 Mucopolysaccharidosis, type II
0.001 0.944 0.055
E76.0 Mucopolysaccharidosis, type I
0.001 0.944 0.055
E77.9 Disorder of glycoprotein metabolism, unspecified
0.001 0.944 0.055
E77.8 Other disorders of glycoprotein metabolism
0.001 0.944 0.055
E77.1 Defects in glycoprotein degradation
0.001 0.944 0.055
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.001 0.944 0.055
E84.9 Cystic fibrosis, unspecified
0.001 0.944 0.055
E85.8 Other amyloidosis
0.001 0.944 0.055
E21.0 Primary hyperparathyroidism
0.000 0.944 0.056
E85.2 Heredofamilial amyloidosis, unspecified
0.001 0.944 0.055
E85.1 Neuropathic heredofamilial amyloidosis
0.001 0.944 0.055
E85.0 Nonneuropathic heredofamilial amyloidosis
0.001 0.944 0.055
E73.8 Other lactose intolerance
0.001 0.945 0.055
E73.1 Secondary lactase deficiency
0.001 0.945 0.055
E73.0 Congenital lactase deficiency
0.001 0.945 0.055
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.945 0.055
E22 Hyperfunction of pituitary gland
0.000 0.945 0.055
E73.9 Lactose intolerance, unspecified
0.001 0.946 0.054
E34.8 Other specified endocrine disorders
0.000 0.946 0.054
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.001 0.947 0.053
E70.8 Other disorders of aromatic amino-acid metabolism
0.001 0.947 0.053
E70.2 Disorders of tyrosine metabolism
0.001 0.947 0.053
E70.1 Other hyperphenylalaninaemias
0.001 0.947 0.053
E70.0 Classical phenylketonuria
0.001 0.947 0.053
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.001 0.947 0.052
E79.8 Other disorders of purine and pyrimidine metabolism
0.001 0.947 0.052
E79.1 Lesch-Nyhan syndrome
0.001 0.947 0.052
E23 Hypofunction and other disorders of pituitary gland
0.000 0.947 0.052
E34.9 Endocrine disorder, unspecified
0.000 0.948 0.052
E72.9 Disorder of amino-acid metabolism, unspecified
0.001 0.949 0.050
E72.8 Other specified disorders of amino-acid metabolism
0.001 0.949 0.050
E72.5 Disorders of glycine metabolism
0.001 0.949 0.050
E72.4 Disorders of ornithine metabolism
0.001 0.949 0.050
E72.3 Disorders of lysine and hydroxylysine metabolism
0.001 0.949 0.050
E72.2 Disorders of urea cycle metabolism
0.001 0.949 0.050
E88.3 Tumour lysis syndrome
0.001 0.949 0.050
C15.4 Middle third of oesophagus
0.000 0.950 0.050
C15.5 Lower third of oesophagus
0.000 0.950 0.050
E72.0 Disorders of amino-acid transport
0.001 0.950 0.049
E70.3 Albinism
0.001 0.950 0.048
C25 Malignant neoplasm of pancreas
0.000 0.951 0.049
E26.8 Other hyperaldosteronism
0.000 0.951 0.048
E26.1 Secondary hyperaldosteronism
0.000 0.951 0.048
E34.0 Carcinoid syndrome
0.000 0.952 0.047
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.001 0.953 0.046
I73.9 Peripheral vascular disease, unspecified
0.000 0.953 0.047
I73 Other peripheral vascular diseases
0.000 0.953 0.046
E78.8 Other disorders of lipoprotein metabolism
0.000 0.954 0.046
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.001 0.954 0.045
E23.7 Disorder of pituitary gland, unspecified
0.000 0.955 0.045
I77 Other disorders of arteries and arterioles
0.000 0.955 0.045
C15.9 Oesophagus, unspecified
0.000 0.955 0.045
E29.1 Testicular hypofunction
0.000 0.955 0.045
I70-I79 Diseases of arteries, arterioles and capillaries
0.000 0.955 0.045
C15.0 Cervical part of oesophagus
0.000 0.956 0.044
E04 Other non-toxic goitre
0.002 0.956 0.042
E80 Disorders of porphyrin and bilirubin metabolism
0.001 0.956 0.043
I77.6 Arteritis, unspecified
0.000 0.957 0.043
C17 Malignant neoplasm of small intestine
0.000 0.957 0.043
E26.9 Hyperaldosteronism, unspecified
0.001 0.957 0.042
C24 Malignant neoplasm of other and unspecified parts of biliary tract
0.000 0.958 0.042
I74 Arterial embolism and thrombosis
0.000 0.958 0.042
C25.3 Pancreatic duct
0.000 0.958 0.042
C15.1 Thoracic part of oesophagus
0.000 0.958 0.042
C15.3 Upper third of oesophagus
0.000 0.958 0.041
I77.9 Disorder of arteries and arterioles, unspecified
0.000 0.959 0.041
C15.8 Overlapping lesion of oesophagus
0.000 0.959 0.041
C15.2 Abdominal part of oesophagus
0.000 0.959 0.041
C17.0 Duodenum
0.000 0.959 0.041
I73.0 Raynaud's syndrome
0.000 0.959 0.041
C25.2 Tail of pancreas
0.000 0.960 0.040
I74.5 Embolism and thrombosis of iliac artery
0.000 0.960 0.040
I72 Other aneurysm
0.000 0.960 0.040
C25.1 Body of pancreas
0.000 0.960 0.040
E22.8 Other hyperfunction of pituitary gland
0.000 0.961 0.039
I74.3 Embolism and thrombosis of arteries of the lower extremities
0.000 0.961 0.039
I77.8 Other specified disorders of arteries and arterioles
0.000 0.961 0.039
C25.8 Overlapping lesion of pancreas
0.000 0.962 0.038
C25.4 Endocrine pancreas
0.000 0.962 0.038
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.962 0.038
E23.1 Drug-induced hypopituitarism
0.000 0.962 0.038
C24.0 Extrahepatic bile duct
0.000 0.963 0.037
E85.9 Amyloidosis, unspecified
0.001 0.963 0.036
E22.1 Hyperprolactinaemia
0.000 0.963 0.037
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.963 0.037
C21 Malignant neoplasm of anus and anal canal
0.000 0.964 0.036
I74.4 Embolism and thrombosis of arteries of extremities, unspecified
0.000 0.964 0.036
I73.8 Other specified peripheral vascular diseases
0.000 0.964 0.035
I70 Atherosclerosis
0.000 0.965 0.035
I77.3 Arterial fibromuscular dysplasia
0.000 0.965 0.034
I72.4 Aneurysm of artery of lower extremity
0.000 0.966 0.034
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.000 0.966 0.034
I77.1 Stricture of artery
0.000 0.966 0.034
E80.2 Other porphyria
0.001 0.967 0.033
I72.3 Aneurysm of iliac artery
0.000 0.967 0.033
I77.2 Rupture of artery
0.000 0.967 0.033
I77.5 Necrosis of artery
0.000 0.967 0.033
I77.4 Coeliac artery compression syndrome
0.000 0.967 0.033
C25.9 Pancreas, unspecified
0.000 0.968 0.032
C25.7 Other parts of pancreas
0.000 0.968 0.032
I74.2 Embolism and thrombosis of arteries of the upper extremities
0.000 0.968 0.032
E04.8 Other specified non-toxic goitre
0.001 0.968 0.030
E80.7 Disorder of bilirubin metabolism, unspecified
0.001 0.968 0.031
E80.5 Crigler-Najjar syndrome
0.001 0.968 0.031
E80.3 Defects of catalase and peroxydase
0.001 0.968 0.031
E80.0 Hereditary erythropoietic porphyria
0.001 0.968 0.031
I72.0 Aneurysm of carotid artery
0.000 0.969 0.031
E53.8 Deficiency of other specified B group vitamins
0.000 0.969 0.031
I72.1 Aneurysm of artery of upper extremity
0.000 0.969 0.031
C17.8 Overlapping lesion of small intestine
0.000 0.969 0.031
C17.3 Meckel's diverticulum
0.000 0.969 0.031
I73.1 Thromboangiitis obliterans [Buerger]
0.000 0.969 0.031
C24.8 Overlapping lesion of biliary tract
0.000 0.969 0.030
E78.0 Pure hypercholesterolaemia
0.000 0.970 0.030
I74.0 Embolism and thrombosis of abdominal aorta
0.000 0.970 0.030
C24.9 Biliary tract, unspecified
0.000 0.970 0.030
E66 Obesity
0.000 0.971 0.029
I72.6 Aneurysm and dissection of vertebral artery
0.000 0.971 0.029
I72.5 Aneurysm and dissection of other precerebral arteries
0.000 0.971 0.029
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.971 0.028
I70.2 Atherosclerosis of arteries of the extremities
0.000 0.971 0.028
M45-M49 Spondylopathies
0.028 0.972 0.000
I72.9 Aneurysm of unspecified site
0.000 0.972 0.028
C21.8 Overlapping lesion of rectum, anus and anal canal
0.000 0.972 0.028
E80.6 Other disorders of bilirubin metabolism
0.001 0.972 0.027
C17.1 Jejunum
0.000 0.972 0.027
I70.8 Atherosclerosis of other arteries
0.000 0.973 0.027
C26 Malignant neoplasm of other and ill-defined digestive organs
0.000 0.973 0.027
I70.1 Atherosclerosis of renal artery
0.000 0.973 0.026
E22.0 Acromegaly and pituitary gigantism
0.000 0.974 0.026
E80.1 Porphyria cutanea tarda
0.001 0.974 0.025
C21.2 Cloacogenic zone
0.000 0.974 0.026
I72.2 Aneurysm of renal artery
0.000 0.974 0.026
E26.0 Primary hyperaldosteronism
0.001 0.974 0.025
I80-I89 Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified
0.026 0.974 0.000
C23 Malignant neoplasm of gallbladder
0.000 0.974 0.025
I79.8 Other disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.000 0.975 0.025
E23.6 Other disorders of pituitary gland
0.000 0.975 0.025
E83.5 Disorders of calcium metabolism
0.005 0.975 0.020
K90-K93 Other diseases of the digestive system
0.000 0.975 0.025
I72.8 Aneurysm of other specified arteries
0.000 0.975 0.025
I79.2 Peripheral angiopathy in diseases classified elsewhere
0.000 0.975 0.025
I70.9 Generalised and unspecified atherosclerosis
0.000 0.975 0.025
I74.1 Embolism and thrombosis of other and unspecified parts of aorta
0.000 0.975 0.024
E23.2 Diabetes insipidus
0.000 0.975 0.024
I79.1 Aortitis in diseases classified elsewhere
0.000 0.975 0.024
I79.0 Aneurysm of aorta in diseases classified elsewhere
0.000 0.975 0.024
I70.0 Atherosclerosis of aorta
0.000 0.976 0.024
C22 Malignant neoplasm of liver and intrahepatic bile ducts
0.000 0.976 0.024
I89 Other non-infective disorders of lymphatic vessels and lymph nodes
0.023 0.977 0.000
I70.21 Atherosclerosis of arteries of extremities (with gangrene)
0.000 0.977 0.023
R31 Unspecified haematuria
0.023 0.977 0.000
I86 Varicose veins of other sites
0.023 0.977 0.000
E04.0 Non-toxic diffuse goitre
0.002 0.977 0.021
C21.0 Anus, unspecified
0.000 0.978 0.022
C21.1 Anal canal
0.000 0.978 0.022
M49 Spondylopathies in diseases classified elsewhere
0.022 0.978 0.000
E11.9 Without complications
0.000 0.978 0.022
I89.9 Non-infective disorder of lymphatic vessels and lymph nodes, unspecified
0.021 0.979 0.000
I89.0 Lymphoedema, not elsewhere classified
0.021 0.979 0.000
E66.1 Drug-induced obesity
0.000 0.979 0.021
M46 Other inflammatory spondylopathies
0.021 0.979 0.000
I86.8 Varicose veins of other specified sites
0.021 0.979 0.000
I70.80 Atherosclerosis of other arteries (without gangrene)
0.000 0.979 0.021
I70.20 Atherosclerosis of arteries of extremities (without gangrene)
0.000 0.979 0.021

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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