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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2157081
log Bayes Factor = 29.1524
Chromosome 6   position 32,761,776  (GRCh37) Explore rs2157081 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
K90.0 Coeliac disease
0.000 0.000 1.000
L40.5 Arthropathic psoriasis
0.000 0.000 1.000
C44 Other malignant neoplasms of skin
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
G35 Multiple sclerosis
1.000 0.000 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.001 0.999
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.001 0.999
L40 Psoriasis
0.000 0.001 0.999
E20-E35 Disorders of other endocrine glands
0.000 0.001 0.999
C44.7 Skin of lower limb, including hip
0.000 0.001 0.999
E00-E07 Disorders of thyroid gland
0.000 0.001 0.999
E10.3 With ophthalmic complications
0.000 0.002 0.998
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.002 0.998
C44.6 Skin of upper limb, including shoulder
0.000 0.002 0.998
L40.9 Psoriasis, unspecified
0.000 0.003 0.997
C44.3 Skin of other and unspecified parts of face
0.000 0.003 0.997
E05.9 Thyrotoxicosis, unspecified
0.000 0.005 0.995
E23 Hypofunction and other disorders of pituitary gland
0.000 0.013 0.987
L57.0 Actinic keratosis
0.000 0.021 0.979
C44.4 Skin of scalp and neck
0.000 0.025 0.975
E27 Other disorders of adrenal gland
0.000 0.027 0.973
J45.9 Asthma, unspecified
0.971 0.029 0.000
G35-G37 Demyelinating diseases of the central nervous system
0.966 0.034 0.000
G37 Other demyelinating diseases of central nervous system
0.954 0.046 0.000
C44.2 Skin of ear and external auricular canal
0.000 0.057 0.943
E23.7 Disorder of pituitary gland, unspecified
0.000 0.060 0.940
E23.6 Other disorders of pituitary gland
0.000 0.063 0.937
G37.9 Demyelinating disease of central nervous system, unspecified
0.933 0.067 0.000
E10.9 Without complications
0.000 0.068 0.932
E27.1 Primary adrenocortical insufficiency
0.000 0.069 0.931
E10.2 With renal complications
0.000 0.083 0.917
E10.5 With peripheral circulatory complications
0.000 0.090 0.910
J45 Asthma
0.893 0.107 0.000
E24 Cushing's syndrome
0.000 0.107 0.893
E10.1 With ketoacidosis
0.000 0.113 0.887
G37.8 Other specified demyelinating diseases of central nervous system
0.876 0.124 0.000
J45.0 Predominantly allergic asthma
0.871 0.129 0.000
L40-L45 Papulosquamous disorders
0.000 0.145 0.855
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.155 0.845
E28 Ovarian dysfunction
0.000 0.156 0.844
L57 Skin changes due to chronic exposure to nonionising radiation
0.000 0.161 0.839
L40.1 Generalised pustular psoriasis
0.000 0.171 0.829
L40.3 Pustulosis palmaris et plantaris
0.000 0.172 0.828
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.201 0.799
G36 Other acute disseminated demyelination
0.788 0.212 0.000
E10.0 With coma
0.000 0.220 0.780
C44.0 Skin of lip
0.000 0.222 0.778
E10.4 With neurological complications
0.000 0.225 0.775
E06 Thyroiditis
0.000 0.230 0.770
L40.4 Guttate psoriasis
0.000 0.230 0.770
M07.3 Other psoriatic arthropathies
0.000 0.230 0.770
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.231 0.769
M07.39 Other psoriatic arthropathies (Site unspecified)
0.000 0.233 0.767
E23.0 Hypopituitarism
0.000 0.235 0.765
M07.30 Other psoriatic arthropathies (Multiple sites)
0.000 0.236 0.764
E83.1 Disorders of iron metabolism
0.763 0.237 0.000
E13 Other specified diabetes mellitus
0.000 0.238 0.762
E29 Testicular dysfunction
0.000 0.244 0.755
L55-L59 Radiation-related disorders of the skin and subcutaneous tissue
0.000 0.250 0.750
L43 Lichen planus
0.000 0.251 0.749
L40.0 Psoriasis vulgaris
0.000 0.254 0.746
E24.0 Pituitary-dependent Cushing's disease
0.000 0.261 0.738
E26 Hyperaldosteronism
0.000 0.263 0.737
E24.2 Drug-induced Cushing's syndrome
0.000 0.269 0.731
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.270 0.730
E28.2 Polycystic ovarian syndrome
0.000 0.279 0.721
E10.7 With multiple complications
0.000 0.283 0.717
C44.8 Overlapping lesion of skin
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.716
E05.5 Thyroid crisis or storm
0.000 0.283 0.716
E05.4 Thyrotoxicosis factitia
0.000 0.283 0.716
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.283 0.716
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.283 0.716
L40.2 Acrodermatitis continua
0.000 0.283 0.716
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.284 0.716
E32 Diseases of thymus
0.000 0.284 0.716
E31 Polyglandular dysfunction
0.000 0.284 0.716
E30 Disorders of puberty, not elsewhere classified
0.000 0.284 0.716
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.284 0.716
E00 Congenital iodine-deficiency syndrome
0.000 0.284 0.716
E27.9 Disorder of adrenal gland, unspecified
0.000 0.285 0.715
L57.8 Other skin changes due to chronic exposure to nonionising radiation
0.000 0.291 0.709
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.292 0.708
E23.1 Drug-induced hypopituitarism
0.000 0.292 0.708
M07.36 Other psoriatic arthropathies (Lower leg)
0.000 0.292 0.708
E27.5 Adrenomedullary hyperfunction
0.000 0.303 0.697
E27.0 Other adrenocortical overactivity
0.000 0.303 0.697
E24.9 Cushing's syndrome, unspecified
0.000 0.303 0.697
M07.37 Other psoriatic arthropathies (Ankle and foot)
0.000 0.303 0.697
E11 Non-insulin-dependent diabetes mellitus
0.000 0.305 0.695
Chapter XII Diseases of the skin and subcutaneous tissue
0.000 0.314 0.686
G37.5 Concentric sclerosis [Balo]
0.684 0.316 0.000
G37.4 Subacute necrotising myelitis
0.684 0.316 0.000
G37.2 Central pontine myelinolysis
0.684 0.316 0.000
G37.1 Central demyelination of corpus callosum
0.684 0.316 0.000
G37.0 Diffuse sclerosis
0.684 0.316 0.000
J45.8 Mixed asthma
0.682 0.318 0.000
E25 Adrenogenital disorders
0.000 0.327 0.673
E11.3 With ophthalmic complications
0.000 0.331 0.669
E34 Other endocrine disorders
0.000 0.334 0.666
J45.1 Nonallergic asthma
0.666 0.334 0.000
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.334 0.665
E06.3 Autoimmune thyroiditis
0.000 0.337 0.663
E05.8 Other thyrotoxicosis
0.000 0.338 0.662
G36.0 Neuromyelitis optica [Devic]
0.660 0.340 0.000
E65-E68 Obesity and other hyperalimentation
0.000 0.341 0.659
E10.6 With other specified complications
0.000 0.344 0.656
E21.3 Hyperparathyroidism, unspecified
0.000 0.346 0.654
L43.9 Lichen planus, unspecified
0.000 0.347 0.653
M07.34 Other psoriatic arthropathies (Hand)
0.000 0.357 0.643
E24.8 Other Cushing's syndrome
0.000 0.360 0.640
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.360 0.640
E24.3 Ectopic ACTH syndrome
0.000 0.360 0.640
E24.1 Nelson's syndrome
0.000 0.360 0.640
E23.2 Diabetes insipidus
0.000 0.367 0.633
E40-E46 Malnutrition
0.000 0.368 0.631
E28.3 Primary ovarian failure
0.000 0.370 0.630
E27.8 Other specified disorders of adrenal gland
0.000 0.378 0.622
E27.2 Addisonian crisis
0.000 0.380 0.620
E70-E90 Metabolic disorders
0.000 0.381 0.619
L44 Other papulosquamous disorders
0.000 0.387 0.613
L41 Parapsoriasis
0.000 0.387 0.613
L45 Papulosquamous disorders in diseases classified elsewhere
0.000 0.387 0.613
E20 Hypoparathyroidism
0.000 0.390 0.610
E28.9 Ovarian dysfunction, unspecified
0.000 0.395 0.605
E28.8 Other ovarian dysfunction
0.000 0.395 0.605
E28.1 Androgen excess
0.000 0.395 0.605
E28.0 Oestrogen excess
0.000 0.395 0.605
L57.5 Actinic granuloma
0.000 0.398 0.601
L57.3 Poikiloderma of Civatte
0.000 0.398 0.601
L57.2 Cutis rhomboidalis nuchae
0.000 0.398 0.601
L57.1 Actinic reticuloid
0.000 0.398 0.601
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.597 0.402 0.000
E04 Other non-toxic goitre
0.000 0.404 0.596
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.410 0.590
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.415 0.585
E10.8 With unspecified complications
0.000 0.417 0.583
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.417 0.583
E29.1 Testicular hypofunction
0.000 0.419 0.581
L43.8 Other lichen planus
0.000 0.420 0.579
L56 Other acute skin changes due to ultraviolet radiation
0.000 0.420 0.579
E13.9 Without complications
0.000 0.421 0.579
E11.2 With renal complications
0.000 0.432 0.568
E06.5 Other chronic thyroiditis
0.000 0.435 0.565
G36.9 Acute disseminated demyelination, unspecified
0.565 0.435 0.000
G36.8 Other specified acute disseminated demyelination
0.565 0.435 0.000
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.565 0.435 0.000
E65 Localised adiposity
0.000 0.435 0.565
E13.3 With ophthalmic complications
0.000 0.439 0.561
L57.9 Skin changes due to chronic exposure to nonionising radiation, unspecified
0.000 0.447 0.553
E06.4 Drug-induced thyroiditis
0.000 0.448 0.552
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.448 0.552
E06.0 Acute thyroiditis
0.000 0.448 0.552
M07.38 Other psoriatic arthropathies (Other)
0.000 0.448 0.552
M07.33 Other psoriatic arthropathies (Forearm)
0.000 0.448 0.552
M07.32 Other psoriatic arthropathies (Upper arm)
0.000 0.448 0.552
M07.31 Other psoriatic arthropathies (Shoulder region)
0.000 0.448 0.552
E89.0 Postprocedural hypothyroidism
0.000 0.448 0.552
E21.4 Other specified disorders of parathyroid gland
0.000 0.448 0.551
E11.0 With coma
0.000 0.449 0.551
E06.9 Thyroiditis, unspecified
0.000 0.450 0.550
E26.0 Primary hyperaldosteronism
0.000 0.450 0.550
E21.2 Other hyperparathyroidism
0.000 0.452 0.548
E78.2 Mixed hyperlipidaemia
0.000 0.454 0.546
E13.8 With unspecified complications
0.000 0.454 0.546
E13.7 With multiple complications
0.000 0.454 0.546
E13.6 With other specified complications
0.000 0.454 0.546
E13.5 With peripheral circulatory complications
0.000 0.454 0.546
E13.4 With neurological complications
0.000 0.454 0.546
E13.2 With renal complications
0.000 0.454 0.546
E13.1 With ketoacidosis
0.000 0.454 0.546
E13.0 With coma
0.000 0.454 0.546
E34.8 Other specified endocrine disorders
0.000 0.455 0.544
E22 Hyperfunction of pituitary gland
0.000 0.455 0.544
E29.9 Testicular dysfunction, unspecified
0.000 0.458 0.542
E29.8 Other testicular dysfunction
0.000 0.458 0.542
E29.0 Testicular hyperfunction
0.000 0.458 0.542
L55 Sunburn
0.000 0.462 0.538
L43.3 Subacute (active) lichen planus
0.000 0.463 0.537
L43.2 Lichenoid drug reaction
0.000 0.463 0.537
L43.1 Bullous lichen planus
0.000 0.463 0.537
L43.0 Hypertrophic lichen planus
0.000 0.463 0.537
E16 Other disorders of pancreatic internal secretion
0.000 0.464 0.536
E04.0 Non-toxic diffuse goitre
0.000 0.467 0.533
E78.5 Hyperlipidaemia, unspecified
0.000 0.467 0.533
L59 Other disorders of skin and subcutaneous tissue related to radiation
0.000 0.467 0.533
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.470 0.530
E26.9 Hyperaldosteronism, unspecified
0.000 0.471 0.529
E26.8 Other hyperaldosteronism
0.000 0.471 0.529
E26.1 Secondary hyperaldosteronism
0.000 0.471 0.529
E15 Nondiabetic hypoglycaemic coma
0.000 0.477 0.523
L40.8 Other psoriasis
0.000 0.478 0.522
E78.6 Lipoprotein deficiency
0.000 0.481 0.519
L42 Pityriasis rosea
0.000 0.482 0.518
E88 Other metabolic disorders
0.000 0.485 0.515
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
E30.9 Disorder of puberty, unspecified
0.000 0.486 0.513
E30.8 Other disorders of puberty
0.000 0.486 0.513
E30.1 Precocious puberty
0.000 0.486 0.513
E30.0 Delayed puberty
0.000 0.486 0.513
E31.9 Polyglandular dysfunction, unspecified
0.000 0.486 0.513
E31.8 Other polyglandular dysfunction
0.000 0.486 0.513
E31.1 Polyglandular hyperfunction
0.000 0.486 0.513
E31.0 Autoimmune polyglandular failure
0.000 0.486 0.513
E32.9 Disease of thymus, unspecified
0.000 0.486 0.513
E32.8 Other diseases of thymus
0.000 0.486 0.513
E32.1 Abscess of thymus
0.000 0.486 0.513
E32.0 Persistent hyperplasia of thymus
0.000 0.486 0.513
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.486 0.513
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.486 0.513
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.486 0.513
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.486 0.513
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.486 0.513
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.486 0.513
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.486 0.513
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.486 0.513
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.486 0.513
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.486 0.513
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.486 0.513
E11.7 With multiple complications
0.000 0.502 0.498
L58 Radiodermatitis
0.000 0.507 0.493
E78.1 Pure hyperglyceridaemia
0.000 0.516 0.484
E25.9 Adrenogenital disorder, unspecified
0.000 0.517 0.482
E25.8 Other adrenogenital disorders
0.000 0.517 0.482
E79 Disorders of purine and pyrimidine metabolism
0.000 0.519 0.481
E11.6 With other specified complications
0.000 0.520 0.480
E11.8 With unspecified complications
0.000 0.521 0.479
E34.5 Androgen resistance syndrome
0.000 0.522 0.478
E34.4 Constitutional tall stature
0.000 0.522 0.478
E34.3 Short stature, not elsewhere classified
0.000 0.522 0.478
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.522 0.478
E34.1 Other hypersecretion of intestinal hormones
0.000 0.522 0.478
L10-L14 Bullous disorders
0.000 0.526 0.474
E67 Other hyperalimentation
0.000 0.528 0.472
E68 Sequelae of hyperalimentation
0.000 0.528 0.472
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.530 0.470
L56.9 Acute skin change due to ultraviolet radiation, unspecified
0.000 0.531 0.469
M07.35 Other psoriatic arthropathies (Pelvic region and thigh)
0.000 0.532 0.468
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.535 0.464
E84 Cystic fibrosis
0.000 0.547 0.453
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.547 0.453
E45 Retarded development following protein-energy malnutrition
0.000 0.547 0.453
E43 Unspecified severe protein-energy malnutrition
0.000 0.547 0.453
E42 Marasmic kwashiorkor
0.000 0.547 0.453
E41 Nutritional marasmus
0.000 0.547 0.453
E40 Kwashiorkor
0.000 0.547 0.453
E89.3 Postprocedural hypopituitarism
0.000 0.551 0.449
E07 Other disorders of thyroid
0.000 0.551 0.449
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.554 0.446
E77 Disorders of glycoprotein metabolism
0.000 0.556 0.444
E76 Disorders of glycosaminoglycan metabolism
0.000 0.556 0.444
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.556 0.444
E70 Disorders of aromatic amino-acid metabolism
0.000 0.556 0.444
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.556 0.444
E21.0 Primary hyperparathyroidism
0.000 0.560 0.440
L41.9 Parapsoriasis, unspecified
0.000 0.560 0.439
L41.8 Other parapsoriasis
0.000 0.560 0.439
L41.5 Retiform parapsoriasis
0.000 0.560 0.439
L41.4 Large plaque parapsoriasis
0.000 0.560 0.439
L41.3 Small plaque parapsoriasis
0.000 0.560 0.439
L41.2 Lymphomatoid papulosis
0.000 0.560 0.439
L41.1 Pityriasis lichenoides chronica
0.000 0.560 0.439
L41.0 Pityriasis lichenoides et varioliformis acuta
0.000 0.560 0.439
L44.9 Papulosquamous disorder, unspecified
0.000 0.560 0.439
L44.8 Other specified papulosquamous disorders
0.000 0.560 0.439
L44.4 Infantile papular acrodermatitis [Giannotti-Crosti]
0.000 0.560 0.439
L44.3 Lichen ruber moniliformis
0.000 0.560 0.439
L44.2 Lichen striatus
0.000 0.560 0.439
L44.1 Lichen nitidus
0.000 0.560 0.439
L44.0 Pityriasis rubra pilaris
0.000 0.560 0.439
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.561 0.439
E20.1 Pseudohypoparathyroidism
0.000 0.562 0.437
E20.0 Idiopathic hypoparathyroidism
0.000 0.562 0.437
L56.8 Other specified acute skin changes due to ultraviolet radiation
0.000 0.566 0.434
L57.4 Cutis laxa senilis
0.000 0.567 0.433
E88.3 Tumour lysis syndrome
0.000 0.572 0.428
E04.8 Other specified non-toxic goitre
0.000 0.572 0.427
E34.9 Endocrine disorder, unspecified
0.000 0.573 0.427
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.576 0.424
E88.8 Other specified metabolic disorders
0.000 0.577 0.423
E06.1 Subacute thyroiditis
0.000 0.580 0.420
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.582 0.418
E89.5 Postprocedural testicular hypofunction
0.000 0.582 0.418
E89.4 Postprocedural ovarian failure
0.000 0.582 0.418
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.583 0.417
L56.3 Solar urticaria
0.000 0.584 0.415
L56.2 Photocontact dermatitis [berloque dermatitis]
0.000 0.584 0.415
L56.1 Drug photoallergic response
0.000 0.584 0.415
L56.0 Drug phototoxic response
0.000 0.584 0.415
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.585 0.415
E04.2 Non-toxic multinodular goitre
0.000 0.585 0.415
E20.9 Hypoparathyroidism, unspecified
0.000 0.591 0.408
C44.9 Malignant neoplasm of skin, unspecified
0.001 0.596 0.403
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.599 0.401
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.607 0.393
E88.2 Lipomatosis, not elsewhere classified
0.000 0.608 0.391
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.609 0.390
E22.8 Other hyperfunction of pituitary gland
0.000 0.609 0.390
E89.1 Postprocedural hypoinsulinaemia
0.000 0.610 0.389
E11.5 With peripheral circulatory complications
0.000 0.613 0.387
E22.1 Hyperprolactinaemia
0.000 0.613 0.387
L55.9 Sunburn, unspecified
0.000 0.614 0.385
L55.8 Other sunburn
0.000 0.614 0.385
L55.2 Sunburn of third degree
0.000 0.614 0.385
L55.1 Sunburn of second degree
0.000 0.614 0.385
L55.0 Sunburn of first degree
0.000 0.614 0.385
E78.4 Other hyperlipidaemia
0.000 0.615 0.385
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.615 0.384
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.615 0.384
E16.4 Abnormal secretion of gastrin
0.000 0.615 0.384
E16.3 Increased secretion of glucagon
0.000 0.615 0.384
L59.9 Disorder of skin and subcutaneous tissue related to radiation, unspecified
0.000 0.618 0.382
L59.0 Erythema ab igne [dermatitis ab igne]
0.000 0.618 0.382
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.618 0.382
E73 Lactose intolerance
0.000 0.619 0.381
E72 Other disorders of amino-acid metabolism
0.000 0.621 0.379
E89.2 Postprocedural hypoparathyroidism
0.000 0.622 0.378
L59.8 Other specified disorders of skin and subcutaneous tissue related to radiation
0.000 0.622 0.377
E78.3 Hyperchylomicronaemia
0.000 0.623 0.377
E16.2 Hypoglycaemia, unspecified
0.000 0.623 0.377
E34.0 Carcinoid syndrome
0.000 0.624 0.376
L56.4 Polymorphous light eruption
0.000 0.625 0.375
E11.1 With ketoacidosis
0.000 0.628 0.372
E20.8 Other hypoparathyroidism
0.000 0.629 0.371
E74 Other disorders of carbohydrate metabolism
0.000 0.630 0.370
E85 Amyloidosis
0.000 0.632 0.368
E46 Unspecified protein-energy malnutrition
0.000 0.632 0.368
E16.1 Other hypoglycaemia
0.000 0.633 0.367
E80.4 Gilbert's syndrome
0.000 0.634 0.366
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.637 0.363
C43-C44 Melanoma and other malignant neoplasms of skin
0.000 0.638 0.362
E04.9 Non-toxic goitre, unspecified
0.000 0.639 0.361
E88.9 Metabolic disorder, unspecified
0.000 0.643 0.357
L58.1 Chronic radiodermatitis
0.000 0.646 0.353
L58.0 Acute radiodermatitis
0.000 0.646 0.353
E78.8 Other disorders of lipoprotein metabolism
0.000 0.647 0.353
L12 Pemphigoid
0.000 0.647 0.352
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.655 0.345
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.655 0.345
E79.1 Lesch-Nyhan syndrome
0.000 0.655 0.345
C44.5 Skin of trunk
0.000 0.660 0.340
L10 Pemphigus
0.000 0.660 0.340
L14 Bullous disorders in diseases classified elsewhere
0.000 0.660 0.340
E67.8 Other specified hyperalimentation
0.000 0.661 0.339
E67.3 Hypervitaminosis D
0.000 0.661 0.339
E67.2 Megavitamin-B6 syndrome
0.000 0.661 0.339
E67.1 Hypercarotenaemia
0.000 0.661 0.339
E67.0 Hypervitaminosis A
0.000 0.661 0.339
L11 Other acantholytic disorders
0.000 0.664 0.335
E84.9 Cystic fibrosis, unspecified
0.000 0.665 0.335
E80.6 Other disorders of bilirubin metabolism
0.000 0.665 0.335
E50-E64 Other nutritional deficiencies
0.000 0.675 0.325
E84.8 Cystic fibrosis with other manifestations
0.000 0.675 0.325
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.675 0.325
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.675 0.325
E44.1 Mild protein-energy malnutrition
0.000 0.675 0.325
E44.0 Moderate protein-energy malnutrition
0.000 0.675 0.325
E07.1 Dyshormogenetic goitre
0.000 0.678 0.322
E07.0 Hypersecretion of calcitonin
0.000 0.678 0.322
E80.7 Disorder of bilirubin metabolism, unspecified
0.000 0.680 0.320
E80.5 Crigler-Najjar syndrome
0.000 0.680 0.320
E80.3 Defects of catalase and peroxydase
0.000 0.680 0.320
E80.0 Hereditary erythropoietic porphyria
0.000 0.680 0.320
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.682 0.318
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.682 0.318
E70.3 Albinism
0.000 0.682 0.318
E70.2 Disorders of tyrosine metabolism
0.000 0.682 0.318
E70.1 Other hyperphenylalaninaemias
0.000 0.682 0.318
E70.0 Classical phenylketonuria
0.000 0.682 0.318
E71.3 Disorders of fatty-acid metabolism
0.000 0.682 0.318
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.682 0.318
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.682 0.318
E71.0 Maple-syrup-urine disease
0.000 0.682 0.318
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.682 0.318
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.682 0.318
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.682 0.318
E76.2 Other mucopolysaccharidoses
0.000 0.682 0.318
E76.1 Mucopolysaccharidosis, type II
0.000 0.682 0.318
E76.0 Mucopolysaccharidosis, type I
0.000 0.682 0.318
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.682 0.318
E77.8 Other disorders of glycoprotein metabolism
0.000 0.682 0.318
E77.1 Defects in glycoprotein degradation
0.000 0.682 0.318
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.682 0.318
L13 Other bullous disorders
0.000 0.689 0.311
L58.9 Radiodermatitis, unspecified
0.000 0.691 0.309
E75.6 Lipid storage disorder, unspecified
0.000 0.696 0.304
E75.4 Neuronal ceroid lipofuscinosis
0.000 0.696 0.304
E75.3 Sphingolipidosis, unspecified
0.000 0.696 0.304
E75.1 Other gangliosidosis
0.000 0.696 0.304
E75.0 GM2 gangliosidosis
0.000 0.696 0.304
L60-L75 Disorders of skin appendages
0.000 0.697 0.303
E80.1 Porphyria cutanea tarda
0.000 0.700 0.300
E75.2 Other sphingolipidosis
0.000 0.702 0.297
M07 Psoriatic and enteropathic arthropathies
0.000 0.708 0.292
E75.5 Other lipid storage disorders
0.000 0.709 0.291
E07.8 Other specified disorders of thyroid
0.000 0.712 0.288
E03 Other hypothyroidism
0.000 0.720 0.280
E85.4 Organ-limited amyloidosis
0.000 0.722 0.278
E22.0 Acromegaly and pituitary gigantism
0.000 0.726 0.274
E73.8 Other lactose intolerance
0.000 0.727 0.273
E73.1 Secondary lactase deficiency
0.000 0.727 0.273
E73.0 Congenital lactase deficiency
0.000 0.727 0.273
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.728 0.272
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.728 0.272
E72.5 Disorders of glycine metabolism
0.000 0.728 0.272
E72.4 Disorders of ornithine metabolism
0.000 0.728 0.272
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.728 0.272
E72.2 Disorders of urea cycle metabolism
0.000 0.728 0.272
L12.9 Pemphigoid, unspecified
0.000 0.731 0.269
E78.0 Pure hypercholesterolaemia
0.000 0.733 0.267
E72.0 Disorders of amino-acid transport
0.000 0.733 0.267
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.735 0.265
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.735 0.265
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.735 0.265
E74.2 Disorders of galactose metabolism
0.000 0.735 0.265
E74.1 Disorders of fructose metabolism
0.000 0.735 0.265
L71 Rosacea
0.000 0.736 0.264
E85.9 Amyloidosis, unspecified
0.000 0.736 0.264
E85.2 Heredofamilial amyloidosis, unspecified
0.000 0.736 0.264
E85.1 Neuropathic heredofamilial amyloidosis
0.000 0.736 0.264
E85.0 Nonneuropathic heredofamilial amyloidosis
0.000 0.736 0.264
E74.0 Glycogen storage disease
0.000 0.738 0.262
E83 Disorders of mineral metabolism
0.075 0.739 0.186
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.740 0.260
E51 Thiamine deficiency
0.000 0.741 0.259
E80.2 Other porphyria
0.000 0.744 0.256
L12.8 Other pemphigoid
0.000 0.747 0.253
L12.3 Acquired epidermolysis bullosa
0.000 0.747 0.253
L12.2 Chronic bullous disease of childhood
0.000 0.747 0.253
L12.1 Cicatricial pemphigoid
0.000 0.748 0.252
L12.0 Bullous pemphigoid
0.000 0.750 0.250
E56 Other vitamin deficiencies
0.000 0.756 0.244
L10.9 Pemphigus, unspecified
0.000 0.756 0.244
L10.8 Other pemphigus
0.000 0.756 0.244
L10.5 Drug-induced pemphigus
0.000 0.756 0.244
L10.4 Pemphigus erythematosus
0.000 0.756 0.244
L10.3 Brazilian pemphigus [fogo selvagem]
0.000 0.756 0.244
L10.2 Pemphigus foliaceus
0.000 0.756 0.244
L10.1 Pemphigus vegetans
0.000 0.756 0.244
L10.0 Pemphigus vulgaris
0.000 0.756 0.244
L11.0 Acquired keratosis follicularis
0.000 0.758 0.242
L68 Hypertrichosis
0.000 0.759 0.241
L11.9 Acantholytic disorder, unspecified
0.000 0.759 0.241
L11.8 Other specified acantholytic disorders
0.000 0.759 0.241
E11.4 With neurological complications
0.000 0.764 0.236
L11.1 Transient acantholytic dermatosis [Grover]
0.000 0.765 0.235
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.766 0.233
E50 Vitamin A deficiency
0.000 0.766 0.233
E60 Dietary zinc deficiency
0.000 0.766 0.233
E59 Dietary selenium deficiency
0.000 0.766 0.233
E52 Niacin deficiency [pellagra]
0.000 0.766 0.233
L50-L54 Urticaria and erythema
0.000 0.768 0.232
L66 Cicatricial alopecia [scarring hair loss]
0.000 0.770 0.230
L71.9 Rosacea, unspecified
0.000 0.770 0.230
C43 Malignant melanoma of skin
0.000 0.772 0.228
E85.8 Other amyloidosis
0.000 0.776 0.224
L13.9 Bullous disorder, unspecified
0.000 0.777 0.223
L13.8 Other specified bullous disorders
0.000 0.777 0.223
L13.1 Subcorneal pustular dermatitis
0.000 0.777 0.223
E63 Other nutritional deficiencies
0.000 0.778 0.222
L63 Alopecia areata
0.000 0.779 0.221
C43.3 Malignant melanoma of other and unspecified parts of face
0.000 0.781 0.219
L75 Apocrine sweat disorders
0.000 0.783 0.217
L74 Eccrine sweat disorders
0.000 0.783 0.217
L67 Hair colour and hair shaft abnormalities
0.000 0.783 0.217
L64 Androgenic alopecia
0.000 0.783 0.217
L62 Nail disorders in diseases classified elsewhere
0.000 0.783 0.217
E85.3 Secondary systemic amyloidosis
0.000 0.783 0.217
E55 Vitamin D deficiency
0.000 0.784 0.216
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.001 0.784 0.215
E11.9 Without complications
0.000 0.788 0.212
E51.2 Wernicke's encephalopathy
0.000 0.788 0.211
E73.9 Lactose intolerance, unspecified
0.000 0.790 0.210
E54 Ascorbic acid deficiency
0.000 0.790 0.210
L60 Nail disorders
0.000 0.790 0.210
L70 Acne
0.000 0.790 0.210
M07.5 Arthropathy in ulcerative colitis
0.000 0.790 0.209
M07.4 Arthropathy in Crohn's disease [regional enteritis]
0.000 0.790 0.209
M07.2 Psoriatic spondylitis
0.000 0.790 0.209
M07.1 Arthritis mutilans
0.000 0.790 0.209
M07.0 Distal interphalangeal psoriatic arthropathy
0.000 0.790 0.209
L71.1 Rhinophyma
0.000 0.795 0.205
E58 Dietary calcium deficiency
0.000 0.796 0.204
E03.5 Myxoedema coma
0.000 0.799 0.201
E03.4 Atrophy of thyroid (acquired)
0.000 0.799 0.201
E03.3 Postinfectious hypothyroidism
0.000 0.799 0.201
L60.9 Nail disorder, unspecified
0.000 0.803 0.197
L68.0 Hirsutism
0.000 0.803 0.197
E74.3 Other disorders of intestinal carbohydrate absorption
0.000 0.804 0.196
E03.1 Congenital hypothyroidism without goitre
0.000 0.804 0.195

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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