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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2187686
log Bayes Factor = 30.0271
Chromosome 6   position 32,761,507  (GRCh37) Explore rs2187686 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
K90.0 Coeliac disease
0.000 0.000 1.000
L40.5 Arthropathic psoriasis
0.000 0.000 1.000
C44 Other malignant neoplasms of skin
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
G35 Multiple sclerosis
1.000 0.000 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.000 1.000
L40 Psoriasis
0.000 0.001 0.999
E10-E14 Diabetes mellitus
0.000 0.001 0.999
E20-E35 Disorders of other endocrine glands
0.000 0.001 0.999
E00-E07 Disorders of thyroid gland
0.000 0.001 0.999
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.001 0.999
C44.7 Skin of lower limb, including hip
0.000 0.001 0.999
E10.3 With ophthalmic complications
0.000 0.001 0.999
C44.6 Skin of upper limb, including shoulder
0.000 0.001 0.999
C44.3 Skin of other and unspecified parts of face
0.000 0.002 0.998
L40.9 Psoriasis, unspecified
0.000 0.002 0.998
E05.9 Thyrotoxicosis, unspecified
0.000 0.004 0.996
E23 Hypofunction and other disorders of pituitary gland
0.000 0.013 0.987
L57.0 Actinic keratosis
0.000 0.018 0.982
C44.4 Skin of scalp and neck
0.000 0.023 0.977
J45.9 Asthma, unspecified
0.969 0.031 0.000
E27 Other disorders of adrenal gland
0.000 0.032 0.968
G35-G37 Demyelinating diseases of the central nervous system
0.964 0.036 0.000
G37 Other demyelinating diseases of central nervous system
0.952 0.048 0.000
C44.2 Skin of ear and external auricular canal
0.000 0.058 0.942
E23.7 Disorder of pituitary gland, unspecified
0.000 0.060 0.940
G37.9 Demyelinating disease of central nervous system, unspecified
0.931 0.069 0.000
E23.6 Other disorders of pituitary gland
0.000 0.071 0.929
E27.1 Primary adrenocortical insufficiency
0.000 0.076 0.924
E10.9 Without complications
0.000 0.080 0.920
E10.2 With renal complications
0.000 0.083 0.917
E10.5 With peripheral circulatory complications
0.000 0.091 0.909
E10.1 With ketoacidosis
0.000 0.104 0.896
E24 Cushing's syndrome
0.000 0.108 0.892
J45 Asthma
0.885 0.115 0.000
G37.8 Other specified demyelinating diseases of central nervous system
0.874 0.126 0.000
J45.0 Predominantly allergic asthma
0.862 0.138 0.000
E28 Ovarian dysfunction
0.000 0.140 0.860
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.161 0.839
L40-L45 Papulosquamous disorders
0.000 0.163 0.837
L40.1 Generalised pustular psoriasis
0.000 0.171 0.829
L40.3 Pustulosis palmaris et plantaris
0.000 0.171 0.828
L57 Skin changes due to chronic exposure to nonionising radiation
0.000 0.176 0.824
E83.1 Disorders of iron metabolism
0.820 0.180 0.000
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.205 0.795
C44.0 Skin of lip
0.000 0.208 0.792
G36 Other acute disseminated demyelination
0.786 0.214 0.000
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.214 0.786
E23.0 Hypopituitarism
0.000 0.215 0.785
E10.0 With coma
0.000 0.221 0.779
L40.0 Psoriasis vulgaris
0.000 0.224 0.776
E10.4 With neurological complications
0.000 0.226 0.774
L40.4 Guttate psoriasis
0.000 0.230 0.770
E29 Testicular dysfunction
0.000 0.231 0.769
E06 Thyroiditis
0.000 0.232 0.768
M07.3 Other psoriatic arthropathies
0.000 0.236 0.764
M07.39 Other psoriatic arthropathies (Site unspecified)
0.000 0.239 0.761
E13 Other specified diabetes mellitus
0.000 0.239 0.761
M07.30 Other psoriatic arthropathies (Multiple sites)
0.000 0.242 0.758
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.261 0.739
E24.0 Pituitary-dependent Cushing's disease
0.000 0.262 0.738
E26 Hyperaldosteronism
0.000 0.263 0.737
L55-L59 Radiation-related disorders of the skin and subcutaneous tissue
0.000 0.266 0.734
E28.2 Polycystic ovarian syndrome
0.000 0.267 0.733
E24.2 Drug-induced Cushing's syndrome
0.000 0.270 0.730
L43 Lichen planus
0.000 0.282 0.718
C44.8 Overlapping lesion of skin
0.000 0.283 0.717
E10.7 With multiple complications
0.000 0.283 0.717
E05.5 Thyroid crisis or storm
0.000 0.283 0.717
E05.4 Thyrotoxicosis factitia
0.000 0.283 0.717
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.283 0.717
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.283 0.717
L40.2 Acrodermatitis continua
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.284 0.716
E32 Diseases of thymus
0.000 0.284 0.716
E31 Polyglandular dysfunction
0.000 0.284 0.716
E30 Disorders of puberty, not elsewhere classified
0.000 0.284 0.716
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.284 0.716
E00 Congenital iodine-deficiency syndrome
0.000 0.284 0.716
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.293 0.707
E23.1 Drug-induced hypopituitarism
0.000 0.293 0.707
E11 Non-insulin-dependent diabetes mellitus
0.000 0.297 0.703
M07.36 Other psoriatic arthropathies (Lower leg)
0.000 0.298 0.702
E25 Adrenogenital disorders
0.000 0.302 0.698
E24.9 Cushing's syndrome, unspecified
0.000 0.304 0.696
E27.5 Adrenomedullary hyperfunction
0.000 0.306 0.694
E27.0 Other adrenocortical overactivity
0.000 0.306 0.694
M07.37 Other psoriatic arthropathies (Ankle and foot)
0.000 0.308 0.692
E27.9 Disorder of adrenal gland, unspecified
0.000 0.316 0.684
G37.5 Concentric sclerosis [Balo]
0.682 0.317 0.000
G37.4 Subacute necrotising myelitis
0.682 0.317 0.000
G37.2 Central pontine myelinolysis
0.682 0.317 0.000
G37.1 Central demyelination of corpus callosum
0.682 0.317 0.000
G37.0 Diffuse sclerosis
0.682 0.317 0.000
L57.8 Other skin changes due to chronic exposure to nonionising radiation
0.000 0.320 0.679
E21.3 Hyperparathyroidism, unspecified
0.000 0.323 0.677
J45.8 Mixed asthma
0.676 0.324 0.000
E11.3 With ophthalmic complications
0.000 0.324 0.676
Chapter XII Diseases of the skin and subcutaneous tissue
0.000 0.330 0.670
E28.3 Primary ovarian failure
0.000 0.330 0.670
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.334 0.665
E34 Other endocrine disorders
0.000 0.335 0.665
E05.8 Other thyrotoxicosis
0.000 0.338 0.662
E06.3 Autoimmune thyroiditis
0.000 0.340 0.660
J45.1 Nonallergic asthma
0.660 0.340 0.000
G36.0 Neuromyelitis optica [Devic]
0.659 0.341 0.000
E65-E68 Obesity and other hyperalimentation
0.000 0.344 0.656
E10.6 With other specified complications
0.000 0.344 0.656
E24.8 Other Cushing's syndrome
0.000 0.360 0.640
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.360 0.640
E24.3 Ectopic ACTH syndrome
0.000 0.360 0.640
E24.1 Nelson's syndrome
0.000 0.360 0.640
M07.34 Other psoriatic arthropathies (Hand)
0.000 0.362 0.638
E23.2 Diabetes insipidus
0.000 0.368 0.632
E40-E46 Malnutrition
0.000 0.369 0.631
E27.8 Other specified disorders of adrenal gland
0.000 0.381 0.619
E28.9 Ovarian dysfunction, unspecified
0.000 0.383 0.617
E28.8 Other ovarian dysfunction
0.000 0.383 0.617
E28.1 Androgen excess
0.000 0.383 0.617
E28.0 Oestrogen excess
0.000 0.383 0.617
L43.9 Lichen planus, unspecified
0.000 0.388 0.612
E27.2 Addisonian crisis
0.000 0.391 0.609
E20 Hypoparathyroidism
0.000 0.391 0.609
E29.1 Testicular hypofunction
0.000 0.396 0.604
L44 Other papulosquamous disorders
0.000 0.400 0.600
L41 Parapsoriasis
0.000 0.400 0.600
L45 Papulosquamous disorders in diseases classified elsewhere
0.000 0.400 0.600
E04 Other non-toxic goitre
0.000 0.402 0.598
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.402 0.597
L57.5 Actinic granuloma
0.000 0.409 0.590
L57.3 Poikiloderma of Civatte
0.000 0.409 0.590
L57.2 Cutis rhomboidalis nuchae
0.000 0.409 0.590
L57.1 Actinic reticuloid
0.000 0.409 0.590
E10.8 With unspecified complications
0.000 0.417 0.583
E13.9 Without complications
0.000 0.423 0.577
E11.2 With renal complications
0.000 0.426 0.574
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.570 0.430 0.000
L56 Other acute skin changes due to ultraviolet radiation
0.000 0.433 0.567
G36.9 Acute disseminated demyelination, unspecified
0.564 0.436 0.000
G36.8 Other specified acute disseminated demyelination
0.564 0.436 0.000
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.564 0.436 0.000
E21.4 Other specified disorders of parathyroid gland
0.000 0.436 0.564
E06.5 Other chronic thyroiditis
0.000 0.437 0.563
E65 Localised adiposity
0.000 0.437 0.563
E21.2 Other hyperparathyroidism
0.000 0.440 0.560
E13.3 With ophthalmic complications
0.000 0.440 0.560
E11.0 With coma
0.000 0.443 0.557
L43.8 Other lichen planus
0.000 0.444 0.556
E16 Other disorders of pancreatic internal secretion
0.000 0.448 0.552
E29.9 Testicular dysfunction, unspecified
0.000 0.449 0.551
E29.8 Other testicular dysfunction
0.000 0.449 0.551
E29.0 Testicular hyperfunction
0.000 0.449 0.551
E06.4 Drug-induced thyroiditis
0.000 0.449 0.551
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.449 0.551
E06.0 Acute thyroiditis
0.000 0.449 0.551
E26.0 Primary hyperaldosteronism
0.000 0.451 0.549
E06.9 Thyroiditis, unspecified
0.000 0.452 0.548
M07.38 Other psoriatic arthropathies (Other)
0.000 0.452 0.548
M07.33 Other psoriatic arthropathies (Forearm)
0.000 0.452 0.548
M07.32 Other psoriatic arthropathies (Upper arm)
0.000 0.452 0.548
M07.31 Other psoriatic arthropathies (Shoulder region)
0.000 0.452 0.548
E13.8 With unspecified complications
0.000 0.454 0.545
E13.7 With multiple complications
0.000 0.454 0.545
E13.6 With other specified complications
0.000 0.454 0.545
E13.5 With peripheral circulatory complications
0.000 0.454 0.545
E13.4 With neurological complications
0.000 0.454 0.545
E13.2 With renal complications
0.000 0.454 0.545
E13.1 With ketoacidosis
0.000 0.454 0.545
E13.0 With coma
0.000 0.454 0.545
E34.8 Other specified endocrine disorders
0.000 0.456 0.544
L57.9 Skin changes due to chronic exposure to nonionising radiation, unspecified
0.000 0.457 0.543
E22 Hyperfunction of pituitary gland
0.000 0.457 0.543
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.458 0.541
E04.0 Non-toxic diffuse goitre
0.000 0.465 0.535
E15 Nondiabetic hypoglycaemic coma
0.000 0.470 0.530
E26.9 Hyperaldosteronism, unspecified
0.000 0.471 0.528
E26.8 Other hyperaldosteronism
0.000 0.471 0.528
E26.1 Secondary hyperaldosteronism
0.000 0.471 0.528
L55 Sunburn
0.000 0.473 0.526
L40.8 Other psoriasis
0.000 0.478 0.522
L59 Other disorders of skin and subcutaneous tissue related to radiation
0.000 0.478 0.522
L43.3 Subacute (active) lichen planus
0.000 0.485 0.515
L43.2 Lichenoid drug reaction
0.000 0.485 0.515
L43.1 Bullous lichen planus
0.000 0.485 0.515
L43.0 Hypertrophic lichen planus
0.000 0.485 0.515
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
E30.9 Disorder of puberty, unspecified
0.000 0.486 0.514
E30.8 Other disorders of puberty
0.000 0.486 0.514
E30.1 Precocious puberty
0.000 0.486 0.514
E30.0 Delayed puberty
0.000 0.486 0.514
E31.9 Polyglandular dysfunction, unspecified
0.000 0.486 0.514
E31.8 Other polyglandular dysfunction
0.000 0.486 0.514
E31.1 Polyglandular hyperfunction
0.000 0.486 0.514
E31.0 Autoimmune polyglandular failure
0.000 0.486 0.514
E32.9 Disease of thymus, unspecified
0.000 0.486 0.514
E32.8 Other diseases of thymus
0.000 0.486 0.514
E32.1 Abscess of thymus
0.000 0.486 0.514
E32.0 Persistent hyperplasia of thymus
0.000 0.486 0.514
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.486 0.514
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.486 0.514
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.486 0.514
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.486 0.513
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.486 0.513
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.486 0.513
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.486 0.513
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.486 0.513
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.486 0.513
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.486 0.513
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.486 0.513
L42 Pityriasis rosea
0.000 0.493 0.507
E11.8 With unspecified complications
0.000 0.496 0.504
E11.7 With multiple complications
0.000 0.496 0.504
E70-E90 Metabolic disorders
0.000 0.496 0.504
E25.9 Adrenogenital disorder, unspecified
0.000 0.499 0.500
E25.8 Other adrenogenital disorders
0.000 0.499 0.500
E11.6 With other specified complications
0.000 0.515 0.485
L58 Radiodermatitis
0.000 0.517 0.483
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.518 0.482
E34.5 Androgen resistance syndrome
0.000 0.523 0.477
E34.4 Constitutional tall stature
0.000 0.523 0.477
E34.3 Short stature, not elsewhere classified
0.000 0.523 0.477
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.523 0.477
E34.1 Other hypersecretion of intestinal hormones
0.000 0.523 0.477
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.525 0.475
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.527 0.473
E67 Other hyperalimentation
0.000 0.529 0.471
E68 Sequelae of hyperalimentation
0.000 0.529 0.471
M07.35 Other psoriatic arthropathies (Pelvic region and thigh)
0.000 0.536 0.464
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.536 0.464
L10-L14 Bullous disorders
0.000 0.537 0.463
E21.0 Primary hyperparathyroidism
0.000 0.539 0.461
L56.9 Acute skin change due to ultraviolet radiation, unspecified
0.000 0.541 0.459
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.547 0.452
E45 Retarded development following protein-energy malnutrition
0.000 0.547 0.452
E43 Unspecified severe protein-energy malnutrition
0.000 0.547 0.452
E42 Marasmic kwashiorkor
0.000 0.547 0.452
E41 Nutritional marasmus
0.000 0.547 0.452
E40 Kwashiorkor
0.000 0.547 0.452
E89.0 Postprocedural hypothyroidism
0.000 0.553 0.447
E07 Other disorders of thyroid
0.000 0.554 0.446
E78.2 Mixed hyperlipidaemia
0.000 0.561 0.439
E20.1 Pseudohypoparathyroidism
0.000 0.563 0.437
E20.0 Idiopathic hypoparathyroidism
0.000 0.563 0.437
L41.9 Parapsoriasis, unspecified
0.000 0.570 0.430
L41.8 Other parapsoriasis
0.000 0.570 0.430
L41.5 Retiform parapsoriasis
0.000 0.570 0.430
L41.4 Large plaque parapsoriasis
0.000 0.570 0.430
L41.3 Small plaque parapsoriasis
0.000 0.570 0.430
L41.2 Lymphomatoid papulosis
0.000 0.570 0.430
L41.1 Pityriasis lichenoides chronica
0.000 0.570 0.430
L41.0 Pityriasis lichenoides et varioliformis acuta
0.000 0.570 0.430
L44.9 Papulosquamous disorder, unspecified
0.000 0.570 0.430
L44.8 Other specified papulosquamous disorders
0.000 0.570 0.430
L44.4 Infantile papular acrodermatitis [Giannotti-Crosti]
0.000 0.570 0.430
L44.3 Lichen ruber moniliformis
0.000 0.570 0.430
L44.2 Lichen striatus
0.000 0.570 0.430
L44.1 Lichen nitidus
0.000 0.570 0.430
L44.0 Pityriasis rubra pilaris
0.000 0.570 0.430
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.570 0.430
E04.8 Other specified non-toxic goitre
0.000 0.571 0.429
E34.9 Endocrine disorder, unspecified
0.000 0.574 0.426
L57.4 Cutis laxa senilis
0.000 0.575 0.425
L56.8 Other specified acute skin changes due to ultraviolet radiation
0.000 0.576 0.424
E06.1 Subacute thyroiditis
0.000 0.581 0.418
E78.6 Lipoprotein deficiency
0.000 0.583 0.417
E88 Other metabolic disorders
0.000 0.584 0.416
E04.2 Non-toxic multinodular goitre
0.000 0.590 0.410
E78.5 Hyperlipidaemia, unspecified
0.000 0.591 0.409
E20.9 Hypoparathyroidism, unspecified
0.000 0.593 0.407
L56.3 Solar urticaria
0.000 0.593 0.407
L56.2 Photocontact dermatitis [berloque dermatitis]
0.000 0.593 0.407
L56.1 Drug photoallergic response
0.000 0.593 0.407
L56.0 Drug phototoxic response
0.000 0.593 0.407
C44.9 Malignant neoplasm of skin, unspecified
0.001 0.597 0.403
E16.2 Hypoglycaemia, unspecified
0.000 0.600 0.400
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.604 0.396
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.604 0.396
E16.4 Abnormal secretion of gastrin
0.000 0.604 0.396
E16.3 Increased secretion of glucagon
0.000 0.604 0.396
E79 Disorders of purine and pyrimidine metabolism
0.000 0.608 0.392
E11.5 With peripheral circulatory complications
0.000 0.610 0.390
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.611 0.389
E22.8 Other hyperfunction of pituitary gland
0.000 0.611 0.389
E78.1 Pure hyperglyceridaemia
0.000 0.611 0.389
E22.1 Hyperprolactinaemia
0.000 0.614 0.385
C43-C44 Melanoma and other malignant neoplasms of skin
0.000 0.617 0.383
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.618 0.382
E16.1 Other hypoglycaemia
0.000 0.622 0.378
L55.9 Sunburn, unspecified
0.000 0.622 0.378
L55.8 Other sunburn
0.000 0.622 0.378
L55.2 Sunburn of third degree
0.000 0.622 0.378
L55.1 Sunburn of second degree
0.000 0.622 0.378
L55.0 Sunburn of first degree
0.000 0.622 0.378
E04.9 Non-toxic goitre, unspecified
0.000 0.623 0.377
E11.1 With ketoacidosis
0.000 0.624 0.376
E34.0 Carcinoid syndrome
0.000 0.625 0.375
L59.9 Disorder of skin and subcutaneous tissue related to radiation, unspecified
0.000 0.626 0.374
L59.0 Erythema ab igne [dermatitis ab igne]
0.000 0.626 0.374
E20.8 Other hypoparathyroidism
0.000 0.629 0.371
L59.8 Other specified disorders of skin and subcutaneous tissue related to radiation
0.000 0.630 0.369
E84 Cystic fibrosis
0.000 0.631 0.369
L56.4 Polymorphous light eruption
0.000 0.632 0.367
E46 Unspecified protein-energy malnutrition
0.000 0.633 0.366
E89.3 Postprocedural hypopituitarism
0.000 0.636 0.364
E77 Disorders of glycoprotein metabolism
0.000 0.639 0.361
E76 Disorders of glycosaminoglycan metabolism
0.000 0.639 0.361
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.639 0.361
E70 Disorders of aromatic amino-acid metabolism
0.000 0.639 0.361
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.639 0.361
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.639 0.361
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.651 0.349
L58.1 Chronic radiodermatitis
0.000 0.653 0.346
L58.0 Acute radiodermatitis
0.000 0.653 0.346
E88.3 Tumour lysis syndrome
0.000 0.654 0.346
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.655 0.345
L12 Pemphigoid
0.000 0.656 0.344
E88.8 Other specified metabolic disorders
0.000 0.658 0.342
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.660 0.339
E89.5 Postprocedural testicular hypofunction
0.000 0.660 0.339
E89.4 Postprocedural ovarian failure
0.000 0.661 0.339
E67.8 Other specified hyperalimentation
0.000 0.662 0.337
E67.3 Hypervitaminosis D
0.000 0.662 0.337
E67.2 Megavitamin-B6 syndrome
0.000 0.662 0.337
E67.1 Hypercarotenaemia
0.000 0.662 0.337
E67.0 Hypervitaminosis A
0.000 0.662 0.337
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.663 0.337
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.663 0.337
C44.5 Skin of trunk
0.000 0.665 0.335
L10 Pemphigus
0.000 0.668 0.332
L14 Bullous disorders in diseases classified elsewhere
0.000 0.668 0.332
L11 Other acantholytic disorders
0.000 0.672 0.327
E44.1 Mild protein-energy malnutrition
0.000 0.675 0.324
E44.0 Moderate protein-energy malnutrition
0.000 0.675 0.324
E50-E64 Other nutritional deficiencies
0.000 0.676 0.324
E07.1 Dyshormogenetic goitre
0.000 0.680 0.320
E07.0 Hypersecretion of calcitonin
0.000 0.680 0.320
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.683 0.317
E89.1 Postprocedural hypoinsulinaemia
0.000 0.684 0.316
E88.2 Lipomatosis, not elsewhere classified
0.000 0.684 0.316
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.689 0.311
L60-L75 Disorders of skin appendages
0.000 0.690 0.310
E72 Other disorders of amino-acid metabolism
0.000 0.691 0.309
E78.4 Other hyperlipidaemia
0.000 0.691 0.309
E89.2 Postprocedural hypoparathyroidism
0.000 0.693 0.307
L13 Other bullous disorders
0.000 0.696 0.304
E78.3 Hyperchylomicronaemia
0.000 0.697 0.303
L58.9 Radiodermatitis, unspecified
0.000 0.697 0.302
E74 Other disorders of carbohydrate metabolism
0.000 0.699 0.301
E73 Lactose intolerance
0.000 0.699 0.300
E85 Amyloidosis
0.000 0.701 0.299
M07 Psoriatic and enteropathic arthropathies
0.000 0.710 0.290
E88.9 Metabolic disorder, unspecified
0.000 0.712 0.288
E07.8 Other specified disorders of thyroid
0.000 0.714 0.286
E03 Other hypothyroidism
0.000 0.716 0.284
E78.8 Other disorders of lipoprotein metabolism
0.000 0.717 0.283
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.719 0.281
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.719 0.281
E79.1 Lesch-Nyhan syndrome
0.000 0.719 0.281
E80.4 Gilbert's syndrome
0.000 0.723 0.277
E22.0 Acromegaly and pituitary gigantism
0.000 0.727 0.273
E84.9 Cystic fibrosis, unspecified
0.000 0.727 0.273
L71 Rosacea
0.000 0.730 0.270
E84.8 Cystic fibrosis with other manifestations
0.000 0.735 0.265
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.735 0.265
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.735 0.265
L12.9 Pemphigoid, unspecified
0.000 0.737 0.263
E80.6 Other disorders of bilirubin metabolism
0.000 0.738 0.262
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.741 0.259
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.741 0.259
E70.3 Albinism
0.000 0.741 0.259
E70.2 Disorders of tyrosine metabolism
0.000 0.741 0.259
E70.1 Other hyperphenylalaninaemias
0.000 0.741 0.259
E70.0 Classical phenylketonuria
0.000 0.741 0.259
E71.3 Disorders of fatty-acid metabolism
0.000 0.741 0.259
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.741 0.259
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.741 0.259
E71.0 Maple-syrup-urine disease
0.000 0.741 0.259
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.741 0.259
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.741 0.259
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.741 0.259
E76.2 Other mucopolysaccharidoses
0.000 0.741 0.259
E76.1 Mucopolysaccharidosis, type II
0.000 0.741 0.259
E76.0 Mucopolysaccharidosis, type I
0.000 0.741 0.259
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.741 0.259
E77.8 Other disorders of glycoprotein metabolism
0.000 0.741 0.259
E77.1 Defects in glycoprotein degradation
0.000 0.741 0.259
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.741 0.259
E51 Thiamine deficiency
0.000 0.742 0.258
L68 Hypertrichosis
0.000 0.746 0.254
E80.7 Disorder of bilirubin metabolism, unspecified
0.000 0.750 0.250
E80.5 Crigler-Najjar syndrome
0.000 0.750 0.250
E80.3 Defects of catalase and peroxydase
0.000 0.750 0.250
E80.0 Hereditary erythropoietic porphyria
0.000 0.750 0.250
E75.6 Lipid storage disorder, unspecified
0.000 0.752 0.247
E75.4 Neuronal ceroid lipofuscinosis
0.000 0.752 0.247
E75.3 Sphingolipidosis, unspecified
0.000 0.752 0.247
E75.1 Other gangliosidosis
0.000 0.752 0.247
E75.0 GM2 gangliosidosis
0.000 0.752 0.247
L12.8 Other pemphigoid
0.000 0.753 0.247
L12.3 Acquired epidermolysis bullosa
0.000 0.753 0.247
L12.2 Chronic bullous disease of childhood
0.000 0.753 0.247
L12.1 Cicatricial pemphigoid
0.000 0.754 0.245
L12.0 Bullous pemphigoid
0.000 0.756 0.244
E56 Other vitamin deficiencies
0.000 0.757 0.243
C43 Malignant melanoma of skin
0.000 0.757 0.243
E75.2 Other sphingolipidosis
0.000 0.758 0.242
L10.9 Pemphigus, unspecified
0.000 0.762 0.238
L10.8 Other pemphigus
0.000 0.762 0.238
L10.5 Drug-induced pemphigus
0.000 0.762 0.238
L10.4 Pemphigus erythematosus
0.000 0.762 0.238
L10.3 Brazilian pemphigus [fogo selvagem]
0.000 0.762 0.238
L10.2 Pemphigus foliaceus
0.000 0.762 0.238
L10.1 Pemphigus vegetans
0.000 0.762 0.238
L10.0 Pemphigus vulgaris
0.000 0.762 0.238
E75.5 Other lipid storage disorders
0.000 0.763 0.237
L11.0 Acquired keratosis follicularis
0.000 0.764 0.236
L66 Cicatricial alopecia [scarring hair loss]
0.000 0.764 0.236
L11.9 Acantholytic disorder, unspecified
0.000 0.765 0.235
L11.8 Other specified acantholytic disorders
0.000 0.765 0.235
E80.1 Porphyria cutanea tarda
0.000 0.765 0.234
L71.9 Rosacea, unspecified
0.000 0.766 0.234
C43.3 Malignant melanoma of other and unspecified parts of face
0.000 0.767 0.233
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.767 0.232
E50 Vitamin A deficiency
0.000 0.767 0.232
E60 Dietary zinc deficiency
0.000 0.767 0.232
E59 Dietary selenium deficiency
0.000 0.767 0.232
E52 Niacin deficiency [pellagra]
0.000 0.767 0.232
E11.4 With neurological complications
0.000 0.769 0.231
L11.1 Transient acantholytic dermatosis [Grover]
0.000 0.770 0.229
E83 Disorders of mineral metabolism
0.077 0.773 0.151
L63 Alopecia areata
0.000 0.774 0.226
E85.4 Organ-limited amyloidosis
0.000 0.774 0.226
L50-L54 Urticaria and erythema
0.000 0.775 0.225
L75 Apocrine sweat disorders
0.000 0.778 0.222
L74 Eccrine sweat disorders
0.000 0.778 0.222
L67 Hair colour and hair shaft abnormalities
0.000 0.778 0.222
L64 Androgenic alopecia
0.000 0.778 0.222
L62 Nail disorders in diseases classified elsewhere
0.000 0.778 0.222
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.778 0.221
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.778 0.221
E72.5 Disorders of glycine metabolism
0.000 0.778 0.221
E72.4 Disorders of ornithine metabolism
0.000 0.778 0.221
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.778 0.221
E72.2 Disorders of urea cycle metabolism
0.000 0.778 0.221
E63 Other nutritional deficiencies
0.000 0.779 0.221
E11.9 Without complications
0.000 0.780 0.220
L60 Nail disorders
0.000 0.782 0.218
L13.9 Bullous disorder, unspecified
0.000 0.782 0.218
L13.8 Other specified bullous disorders
0.000 0.782 0.218
L13.1 Subcorneal pustular dermatitis
0.000 0.782 0.218
E72.0 Disorders of amino-acid transport
0.000 0.782 0.217
E78.0 Pure hypercholesterolaemia
0.000 0.783 0.217
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.784 0.216
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.784 0.216
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.784 0.216
E74.2 Disorders of galactose metabolism
0.000 0.784 0.216
E74.1 Disorders of fructose metabolism
0.000 0.784 0.216
E73.8 Other lactose intolerance
0.000 0.784 0.215
E73.1 Secondary lactase deficiency
0.000 0.784 0.215
E73.0 Congenital lactase deficiency
0.000 0.784 0.215
L68.0 Hirsutism
0.000 0.785 0.215
E85.2 Heredofamilial amyloidosis, unspecified
0.000 0.785 0.214
E85.1 Neuropathic heredofamilial amyloidosis
0.000 0.785 0.214
E85.0 Nonneuropathic heredofamilial amyloidosis
0.000 0.785 0.214
E85.9 Amyloidosis, unspecified
0.000 0.785 0.214
E55 Vitamin D deficiency
0.000 0.786 0.214
E74.0 Glycogen storage disease
0.000 0.786 0.213
E51.2 Wernicke's encephalopathy
0.000 0.789 0.211
L71.1 Rhinophyma
0.000 0.791 0.209
E54 Ascorbic acid deficiency
0.000 0.791 0.209
M07.5 Arthropathy in ulcerative colitis
0.000 0.792 0.208
M07.4 Arthropathy in Crohn's disease [regional enteritis]
0.000 0.792 0.208
M07.2 Psoriatic spondylitis
0.000 0.792 0.208
M07.1 Arthritis mutilans
0.000 0.792 0.208
M07.0 Distal interphalangeal psoriatic arthropathy
0.000 0.792 0.208
L60.9 Nail disorder, unspecified
0.000 0.795 0.205
L70 Acne
0.000 0.795 0.205
E03.5 Myxoedema coma
0.000 0.796 0.204
E03.4 Atrophy of thyroid (acquired)
0.000 0.796 0.204
E03.3 Postinfectious hypothyroidism
0.000 0.796 0.204
E58 Dietary calcium deficiency
0.000 0.797 0.203
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.799 0.201
E80.2 Other porphyria
0.000 0.800 0.200
E03.1 Congenital hypothyroidism without goitre
0.000 0.801 0.198
L65 Other nonscarring hair loss
0.000 0.803 0.196
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.803 0.196
E03.8 Other specified hypothyroidism
0.000 0.805 0.195
L71.8 Other rosacea
0.000 0.806 0.194
L71.0 Perioral dermatitis
0.000 0.806 0.194

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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