TreeWAS – Variant ID: rs2199161

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
O75.6 Delayed delivery after spontaneous or unspecified rupture of membranes	0.071	0.929	0.000
O75 Other complications of labour and delivery, not elsewhere classified	0.066	0.934	0.000
O75.2 Pyrexia during labour, not elsewhere classified	0.064	0.936	0.000
O75.8 Other specified complications of labour and delivery	0.055	0.945	0.000
O75.9 Complication of labour and delivery, unspecified	0.052	0.947	0.000
O75.5 Delayed delivery after artificial rupture of membranes	0.051	0.949	0.000
O72.1 Other immediate postpartum haemorrhage	0.048	0.952	0.000
O75.4 Other complications of obstetric surgery and procedures	0.047	0.952	0.000
O75.1 Shock during or following labour and delivery	0.047	0.952	0.000
O75.0 Maternal distress during labour and delivery	0.047	0.953	0.000
O75.3 Other infection during labour	0.046	0.954	0.000
D32.0 Cerebral meninges	0.044	0.956	0.000
O72 Postpartum haemorrhage	0.035	0.965	0.000
O75.7 Vaginal delivery following previous Caesarean section	0.032	0.968	0.000
O60-O75 Complications of labour and delivery	0.032	0.968	0.000
O63.0 Prolonged first stage (of labour)	0.031	0.969	0.000
O63 Long labour	0.028	0.972	0.000
O64 Obstructed labour due to malposition and malpresentation of foetus	0.028	0.972	0.000
E10.3 With ophthalmic complications	0.000	0.972	0.028
E10 Insulin-dependent diabetes mellitus	0.000	0.973	0.027
O65 Obstructed labour due to maternal pelvic abnormality	0.027	0.973	0.000
E10.2 With renal complications	0.000	0.973	0.027
O72.3 Postpartum coagulation defects	0.025	0.974	0.000
E10.0 With coma	0.000	0.975	0.025
O60 Preterm delivery	0.023	0.977	0.000
E10.9 Without complications	0.000	0.977	0.023
E10.1 With ketoacidosis	0.000	0.977	0.023
O64.2 Obstructed labour due to face presentation	0.023	0.977	0.000
O65.4 Obstructed labour due to foetopelvic disproportion, unspecified	0.023	0.977	0.000
O72.0 Third-stage haemorrhage	0.023	0.977	0.000
O74 Complications of anaesthesia during labour and delivery	0.022	0.978	0.000
O64.1 Obstructed labour due to breech presentation	0.022	0.978	0.000
O64.3 Obstructed labour due to brow presentation	0.022	0.978	0.000
O64.8 Obstructed labour due to other malposition and malpresentation	0.022	0.978	0.000
O69 Labour and delivery complicated by umbilical cord complications	0.022	0.978	0.000
E10.7 With multiple complications	0.000	0.979	0.021
O64.0 Obstructed labour due to incomplete rotation of foetal head	0.021	0.979	0.000
O63.2 Delayed delivery of second twin, triplet, etc.	0.021	0.979	0.000
O65.5 Obstructed labour due to abnormality of maternal pelvic organs	0.020	0.979	0.000
O64.5 Obstructed labour due to compound presentation	0.020	0.979	0.000
E10.8 With unspecified complications	0.000	0.979	0.020
O61 Failed induction of labour	0.020	0.979	0.000
O64.4 Obstructed labour due to shoulder presentation	0.020	0.980	0.000
O69.8 Labour and delivery complicated by other cord complications	0.020	0.980	0.000
E10.4 With neurological complications	0.000	0.980	0.020
O65.9 Obstructed labour due to maternal pelvic abnormality, unspecified	0.019	0.980	0.000
O65.8 Obstructed labour due to other maternal pelvic abnormalities	0.019	0.980	0.000
O65.3 Obstructed labour due to pelvic outlet and midcavity contraction	0.019	0.980	0.000
O65.2 Obstructed labour due to pelvic inlet contraction	0.019	0.980	0.000
O65.1 Obstructed labour due to generally contracted pelvis	0.019	0.980	0.000
O65.0 Obstructed labour due to deformed pelvis	0.019	0.980	0.000
O64.9 Obstructed labour due to malposition and malpresentation, unspecified	0.019	0.980	0.000
E10.5 With peripheral circulatory complications	0.000	0.981	0.019
O67 Labour and delivery complicated by intrapartum haemorrhage, not elsewhere classified	0.018	0.982	0.000
O71 Other obstetric trauma	0.018	0.982	0.000
O68 Labour and delivery complicated by foetal stress [distress]	0.018	0.982	0.000
O69.0 Labour and delivery complicated by prolapse of cord	0.017	0.983	0.000
O68.9 Labour and delivery complicated by foetal stress, unspecified	0.017	0.983	0.000
O60.3 Preterm delivery without spontaneous labour	0.017	0.983	0.000
O60.2 Preterm spontaneous labour with term delivery	0.017	0.983	0.000
O60.1 Preterm spontaneous labour with preterm delivery	0.017	0.983	0.000
O60.0 Preterm labour without delivery	0.017	0.983	0.000
O74.9 Complication of anaesthesia during labour and delivery, unspecified	0.016	0.984	0.000
O74.8 Other complications of anaesthesia during labour and delivery	0.016	0.984	0.000
O74.7 Failed or difficult intubation during labour and delivery	0.016	0.984	0.000
O74.5 Spinal and epidural anaesthesia-induced headache during labour and delivery	0.016	0.984	0.000
O74.4 Toxic reaction to local anaesthesia during labour and delivery	0.016	0.984	0.000
O74.3 Central nervous system complications of anaesthesia during labour and delivery	0.016	0.984	0.000
O74.2 Cardiac complications of anaesthesia during labour and delivery	0.016	0.984	0.000
O74.1 Other pulmonary complications of anaesthesia during labour and delivery	0.016	0.984	0.000
O74.0 Aspiration pneumonitis due to anaesthesia during labour and delivery	0.016	0.984	0.000
O69.5 Labour and delivery complicated by vascular lesion of cord	0.016	0.984	0.000
O69.4 Labour and delivery complicated by vasa praevia	0.016	0.984	0.000
O69.3 Labour and delivery complicated by short cord	0.016	0.984	0.000
O62 Abnormalities of forces of labour	0.015	0.984	0.000
E10.6 With other specified complications	0.000	0.985	0.015
O74.6 Other complications of spinal and epidural anaesthesia during labour and delivery	0.015	0.985	0.000
O72.2 Delayed and secondary postpartum haemorrhage	0.015	0.985	0.000
O61.1 Failed instrumental induction of labour	0.015	0.985	0.000
O61.8 Other failed induction of labour	0.015	0.985	0.000
O71.9 Obstetric trauma, unspecified	0.014	0.985	0.000
O71.8 Other specified obstetric trauma	0.014	0.986	0.000
O73 Retained placenta and membranes, without haemorrhage	0.014	0.986	0.000
O71.6 Obstetric damage to pelvic joints and ligaments	0.014	0.986	0.000
D32 Benign neoplasm of meninges	0.014	0.986	0.000
O61.9 Failed induction of labour, unspecified	0.014	0.986	0.000
O61.0 Failed medical induction of labour	0.014	0.986	0.000
O71.5 Other obstetric injury to pelvic organs	0.013	0.986	0.000
O68.8 Labour and delivery complicated by other evidence of foetal stress	0.014	0.986	0.000
O69.2 Labour and delivery complicated by other cord entanglement	0.013	0.987	0.000
O67.0 Intrapartum haemorrhage with coagulation defect	0.013	0.987	0.000
O71.2 Postpartum inversion of uterus	0.013	0.987	0.000
O71.1 Rupture of uterus during labour	0.013	0.987	0.000
O71.0 Rupture of uterus before onset of labour	0.013	0.987	0.000
O62.1 Secondary uterine inertia	0.013	0.987	0.000
O67.8 Other intrapartum haemorrhage	0.013	0.987	0.000
O66 Other obstructed labour	0.013	0.987	0.000
O62.2 Other uterine inertia	0.012	0.987	0.000
O62.9 Abnormality of forces of labour, unspecified	0.012	0.987	0.000
S92.30 Fracture of metatarsal bone (closed)	0.012	0.988	0.000
O63.9 Long labour, unspecified	0.012	0.988	0.000
O71.3 Obstetric laceration of cervix	0.011	0.988	0.000
O62.8 Other abnormalities of forces of labour	0.011	0.988	0.000
O68.0 Labour and delivery complicated by foetal heart rate anomaly	0.011	0.989	0.000
O69.1 Labour and delivery complicated by cord around neck, with compression	0.011	0.989	0.000
O68.2 Labour and delivery complicated by foetal heart rate anomaly with meconium in amniotic fluid	0.010	0.990	0.000
O71.7 Obstetric haematoma of pelvis	0.010	0.990	0.000
S92.3 Fracture of metatarsal bone	0.010	0.990	0.000
O66.2 Obstructed labour due to unusually large foetus	0.010	0.990	0.000
O66.9 Obstructed labour, unspecified	0.010	0.990	0.000
O68.3 Labour and delivery complicated by biochemical evidence of foetal stress	0.010	0.990	0.000
O69.9 Labour and delivery complicated by cord complication, unspecified	0.009	0.990	0.000
O66.3 Obstructed labour due to other abnormalities of foetus	0.009	0.990	0.000
O66.1 Obstructed labour due to locked twins	0.009	0.990	0.000
Q87.4 Marfan's syndrome	0.010	0.990	0.000
D32.1 Spinal meninges	0.009	0.991	0.000
O66.8 Other specified obstructed labour	0.009	0.991	0.000
O73.1 Retained portions of placenta and membranes, without haemorrhage	0.009	0.991	0.000
O67.9 Intrapartum haemorrhage, unspecified	0.009	0.991	0.000
D32.9 Meninges, unspecified	0.009	0.991	0.000
O70 Perineal laceration during delivery	0.009	0.991	0.000
Q87 Other specified congenital malformation syndromes affecting multiple systems	0.009	0.991	0.000
T82.7 Infection and inflammatory reaction due to other cardiac and vascular devices, implants and grafts	0.000	0.991	0.009
S92 Fracture of foot, except ankle	0.009	0.991	0.000
O66.4 Failed trial of labour, unspecified	0.008	0.991	0.000
F45.8 Other somatoform disorders	0.008	0.992	0.000
O66.0 Obstructed labour due to shoulder dystocia	0.008	0.992	0.000
S92.1 Fracture of talus	0.008	0.992	0.000
O70.2 Third degree perineal laceration during delivery	0.008	0.992	0.000
S92.4 Fracture of great toe	0.008	0.992	0.000
O62.4 Hypertonic, incoordinate and prolonged uterine contractions	0.007	0.992	0.000
S92.40 Fracture of great toe (closed)	0.007	0.992	0.000
S92.31 Fracture of metatarsal bone (open)	0.007	0.992	0.000
O62.0 Primary inadequate contractions	0.007	0.992	0.000
O71.4 Obstetric high vaginal laceration alone	0.007	0.993	0.001
Q87.8 Other specified congenital malformation syndromes, not elsewhere classified	0.007	0.993	0.000
Q80-Q89 Other congenital malformations	0.007	0.993	0.000
S92.10 Fracture of talus (closed)	0.007	0.993	0.000
F32.2 Severe depressive episode without psychotic symptoms	0.007	0.993	0.000
S92.2 Fracture of other tarsal bone(s)	0.007	0.993	0.000
Q87.0 Congenital malformation syndromes predominantly affecting facial appearance	0.007	0.993	0.000
S92.7 Multiple fractures of foot	0.007	0.993	0.000
O63.1 Prolonged second stage (of labour)	0.007	0.993	0.000
S92.11 Fracture of talus (open)	0.007	0.993	0.000
O62.3 Precipitate labour	0.006	0.993	0.000
O68.1 Labour and delivery complicated by meconium in amniotic fluid	0.007	0.993	0.000
M96.0 Pseudarthrosis after fusion or arthrodesis	0.000	0.993	0.007
Q87.1 Congenital malformation syndromes predominantly associated with short stature	0.007	0.993	0.000
Q87.2 Congenital malformation syndromes predominantly involving limbs	0.006	0.993	0.000
Q89 Other congenital malformations, not elsewhere classified	0.007	0.993	0.000
Q87.5 Other congenital malformation syndromes with other skeletal changes	0.006	0.993	0.000
Q87.3 Congenital malformation syndromes involving early overgrowth	0.006	0.993	0.000
S31 Open wound of abdomen, lower back and pelvis	0.006	0.993	0.000
T43.2 Other and unspecified antidepressants	0.006	0.994	0.000
Q89.2 Congenital malformations of other endocrine glands	0.006	0.994	0.000
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]	0.006	0.994	0.000
Q83 Congenital malformations of breast	0.006	0.994	0.000
S92.20 Fracture of other tarsal bone(s) (closed)	0.006	0.994	0.000
T44.7 Beta-Adrenoreceeptor antagonists, not elsewhere classified	0.006	0.994	0.000
Q82 Other congenital malformations of skin	0.006	0.994	0.000
O70.9 Perineal laceration during delivery, unspecified	0.006	0.994	0.000
T40.4 Other synthetic narcotics	0.006	0.994	0.000
S92.5 Fracture of other toe	0.006	0.994	0.000
S31.1 Open wound of abdominal wall	0.006	0.994	0.000
M96.1 Postlaminectomy syndrome, not elsewhere classified	0.000	0.994	0.006
Q80 Congenital ichthyosis	0.006	0.994	0.000
S92.9 Fracture of foot, unspecified	0.006	0.994	0.000
S31.8 Open wound of other and unspecified parts of abdomen	0.006	0.994	0.000
Z63 Other problems related to primary support group, including family circumstances	0.006	0.994	0.000
S92.70 Multiple fractures of foot (closed)	0.006	0.994	0.000
M48.06 Spinal stenosis (Lumbar region)	0.006	0.994	0.000
M96 Postprocedural musculoskeletal disorders, not elsewhere classified	0.000	0.994	0.006
Z63.7 Other stressful life events affecting family and household	0.006	0.994	0.000
Z61 Problems related to negative life events in childhood	0.006	0.994	0.000
T44 Poisoning by drugs primarily affecting the autonomic nervous system	0.005	0.994	0.000
F32.3 Severe depressive episode with psychotic symptoms	0.006	0.994	0.000
O70.3 Fourth degree perineal laceration during delivery	0.005	0.994	0.000
S31.0 Open wound of lower back and pelvis	0.005	0.994	0.000
Q86 Congenital malformation syndromes due to known exogenous causes, not elsewhere classified	0.005	0.995	0.000
Q84 Other congenital malformations of integument	0.005	0.995	0.000
Q81 Epidermolysis bullosa	0.005	0.995	0.000
Z55-Z65 Persons with potential health hazards related to socioeconomic and psychosocial circumstances	0.005	0.995	0.000
S31.7 Multiple open wounds of abdomen, lower back and pelvis	0.005	0.995	0.000
S31.4 Open wound of vagina and vulva	0.005	0.995	0.000
S92.41 Fracture of great toe (open)	0.005	0.995	0.000
S92.21 Fracture of other tarsal bone(s) (open)	0.005	0.995	0.000
T40.5 Cocaine	0.005	0.995	0.000
T36-T50 Poisoning by drugs, medicaments and biological substances	0.005	0.995	0.000
Q83.8 Other congenital malformations of breast	0.005	0.995	0.000
S31.2 Open wound of penis	0.005	0.995	0.000
S36 Injury of intra-abdominal organs	0.005	0.995	0.000
T43 Poisoning by psychotropic drugs, not elsewhere classified	0.005	0.995	0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis	0.005	0.995	0.000
S92.71 Multiple fractures of foot (open)	0.005	0.995	0.000
Z59 Problems related to housing and economic circumstances	0.005	0.995	0.000
Q82.0 Hereditary lymphoedema	0.005	0.995	0.000
T43.3 Phenothiazine antipsychotics and neuroleptics	0.005	0.995	0.000
S92.0 Fracture of calcaneus	0.005	0.995	0.000
T40.1 Heroin	0.005	0.995	0.000
Z58 Problems related to physical environment	0.005	0.995	0.000
Q82.5 Congenital nonneoplastic naevus	0.005	0.995	0.000
T40.2 Other opioids	0.005	0.995	0.000
Z61.4 Problems related to alleged sexual abuse of child by person within primary support group	0.005	0.995	0.000
Z57 Occupational exposure to risk-factors	0.005	0.995	0.000
S32.00 Fracture of lumbar vertebra (closed)	0.000	0.995	0.005
Q89.9 Congenital malformation, unspecified	0.005	0.995	0.000
Q89.8 Other specified congenital malformations	0.005	0.995	0.000
Q89.7 Multiple congenital malformations, not elsewhere classified	0.005	0.995	0.000
Q89.4 Conjoined twins	0.005	0.995	0.000
Q89.1 Congenital malformations of adrenal gland	0.005	0.995	0.000
Q89.0 Congenital malformations of spleen	0.005	0.995	0.000
Z63.5 Disruption of family by separation and divorce	0.005	0.995	0.000
Q89.3 Situs inversus	0.005	0.995	0.000
S31.5 Open wound of other and unspecified external genital organs	0.005	0.995	0.000
T37 Poisoning by other systemic anti-infectives and antiparasitics	0.005	0.995	0.000
Q85 Phakomatoses, not elsewhere classified	0.005	0.995	0.000
S82.40 Fracture of fibula alone (closed)	0.005	0.995	0.000
Q80.9 Congenital ichthyosis, unspecified	0.005	0.995	0.000
M96.5 Postradiation scoliosis	0.000	0.995	0.005
S31.3 Open wound of scrotum and testes	0.005	0.995	0.000
T40.3 Methadone	0.005	0.995	0.000
Z61.5 Problems related to alleged sexual abuse of child by person outside primary support group	0.005	0.995	0.000
Z59.9 Problem relating to housing and economic circumstances, unspecified	0.005	0.995	0.000
C50.1 Central portion of breast	0.000	0.995	0.005
Z63.4 Disappearance and death of family member	0.005	0.995	0.000
F45 Somatoform disorders	0.005	0.995	0.000
Z63.8 Other specified problems related to primary support group	0.005	0.995	0.000
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified	0.005	0.995	0.000
Z63.6 Dependent relative needing care at home	0.005	0.995	0.000
F32 Depressive episode	0.005	0.995	0.000
Q83.3 Accessory nipple	0.005	0.995	0.000
Q82.2 Mastocytosis	0.005	0.995	0.000
T40.9 Other and unspecified psychodysleptics [hallucinogens]	0.005	0.995	0.000
T40.8 Lysergide [LSD]	0.005	0.995	0.000
T40.7 Cannabis (derivatives)	0.005	0.995	0.000
T40.0 Opium	0.005	0.995	0.000
Q83.9 Congenital malformation of breast, unspecified	0.004	0.995	0.000
Q83.2 Absent nipple	0.004	0.995	0.000
Q83.0 Congenital absence of breast with absent nipple	0.004	0.995	0.000
M70.65 Trochanteric bursitis-Pelvic/Thigh	0.005	0.995	0.000
T40.6 Other and unspecified narcotics	0.005	0.995	0.000
T44.9 Other and unspecified drugs primarily affecting the nervous system	0.005	0.995	0.000
Z58.1 Exposure to air pollution	0.005	0.995	0.000
Q82.9 Congenital malformation of skin, unspecified	0.004	0.995	0.000
Q82.4 Ectodermal dysplasia (anhidrotic)	0.004	0.995	0.000
Q82.3 Incontinentia pigmenti	0.004	0.995	0.000
Q82.1 Xeroderma pigmentosum	0.004	0.995	0.000
T37.8 Other specified systemic anti-infectives and antiparasitics	0.005	0.995	0.000
Z57.5 Occupational exposure to toxic agents in other industries	0.005	0.995	0.000
O73.0 Retained placenta, without haemorrhage	0.004	0.995	0.001
Q83.1 Accessory breast	0.004	0.995	0.000
Z61.6 Problems related to alleged physical abuse of child	0.004	0.995	0.000
M89.87 Other specified disorders of bone (Ankle and foot)	0.000	0.995	0.004
S36.8 Injury of other intra-abdominal organs	0.004	0.995	0.000
T36 Poisoning by systemic antibiotics	0.004	0.995	0.000
S36.0 Injury of spleen	0.004	0.996	0.000
S37 Injury of urinary and pelvic organs	0.004	0.996	0.000
M89.8 Other specified disorders of bone	0.000	0.996	0.004
Q80.8 Other congenital ichthyosis	0.004	0.996	0.000
Q80.4 Harlequin foetus	0.004	0.996	0.000
Q80.3 Congenital bullous ichthyosiform erythroderma	0.004	0.996	0.000
Q80.2 Lamellar ichthyosis	0.004	0.996	0.000
Q80.1 X-linked ichthyosis	0.004	0.996	0.000
Q80.0 Ichthyosis vulgaris	0.004	0.996	0.000
S92.91 Fracture of foot, unspecified (open)	0.004	0.996	0.000
S36.1 Injury of liver or gallbladder	0.004	0.996	0.000
Z61.8 Other negative life events in childhood	0.004	0.996	0.000
S36.5 Injury of colon	0.004	0.996	0.000
Z63.9 Problem related to primary support group, unspecified	0.004	0.996	0.000
Z63.3 Absence of family member	0.004	0.996	0.000
Z63.2 Inadequate family support	0.004	0.996	0.000
Z63.1 Problems in relationship with parents and in-laws	0.004	0.996	0.000
S30.1 Contusion of abdominal wall	0.004	0.996	0.000
Z58.5 Exposure to other pollution	0.004	0.996	0.000
Z59.2 Discord with neighbours, lodgers and landlord	0.004	0.996	0.000
S33 Dislocation, sprain and strain of joints and ligaments of lumbar spine and pelvis	0.004	0.996	0.000
S92.51 Fracture of other toe (open)	0.004	0.996	0.000
T47 Poisoning by agents primarily affecting gastro-intestinal system	0.004	0.996	0.000
M89.84 Other specified disorders of bone (Hand)	0.000	0.996	0.004
S92.01 Fracture of calcaneus (open)	0.004	0.996	0.000
M89.0 Algoneurodystrophy	0.000	0.996	0.004
M96.6 Fracture of bone following insertion of orthopaedic implant, joint prosthesis or bone plate	0.000	0.996	0.004
M96.4 Postsurgical lordosis	0.000	0.996	0.004
M96.3 Postlaminectomy kyphosis	0.000	0.996	0.004
M96.2 Postradiation kyphosis	0.000	0.996	0.004
S35 Injury of blood vessels at abdomen, lower back and pelvis level	0.004	0.996	0.000
S30 Superficial injury of abdomen, lower back and pelvis	0.004	0.996	0.000
O66.5 Failed application of vacuum extractor and forceps, unspecified	0.004	0.996	0.000
Z57.2 Occupational exposure to dust	0.004	0.996	0.000
Z61.9 Negative life events in childhood, unspecified	0.004	0.996	0.000
Z61.7 Personal frightening experience in childhood	0.004	0.996	0.000
Z61.3 Events resulting in loss of self-esteem in childhood	0.004	0.996	0.000
Z61.2 Altered pattern of family relationships in childhood	0.004	0.996	0.000
Z61.1 Removal from home in childhood	0.004	0.996	0.000
Z61.0 Loss of love relationship in childhood	0.004	0.996	0.000
M47.26 Other spondylosis with radiculopathy (Lumbar region)	0.004	0.996	0.000
T44.8 Centrally acting and afrenergic-neuron-blocking agents, not elsewhere classified	0.004	0.996	0.000
T44.5 Predominantly Beta-adrenoreceptor agonists, not elsewhere classified	0.004	0.996	0.000
T44.4 Predominantly Alpha-adrenoreceptor agonists, not elsewhere classified	0.004	0.996	0.000
T44.2 Ganglionic blocking drugs, not elsewhere classified	0.004	0.996	0.000
T44.1 Other parasympathomimetics [cholinergics]	0.004	0.996	0.000
T44.0 Anticholinesterase agents	0.004	0.996	0.000
T45.1 Antineoplastic and immunosuppressive drugs	0.004	0.996	0.000
Z65 Problems related to other psychosocial circumstances	0.004	0.996	0.000
Q81.9 Epidermolysis bullosa, unspecified	0.004	0.996	0.000
Q81.8 Other epidermolysis bullosa	0.004	0.996	0.000
Q81.2 Epidermolysis bullosa dystrophica	0.004	0.996	0.000
Q81.1 Epidermolysis bullosa letalis	0.004	0.996	0.000
Q81.0 Epidermolysis bullosa simplex	0.004	0.996	0.000
Q84.9 Congenital malformation of integument, unspecified	0.004	0.996	0.000
Q84.8 Other specified congenital malformations of integument	0.004	0.996	0.000
Q84.6 Other congenital malformations of nails	0.004	0.996	0.000
Q84.5 Enlarged and hypertrophic nails	0.004	0.996	0.000
Q84.4 Congenital leukonychia	0.004	0.996	0.000
Q84.3 Anonychia	0.004	0.996	0.000
Q84.2 Other congenital malformations of hair	0.004	0.996	0.000
Q84.1 Congenital morphological disturbances of hair, not elsewhere classified	0.004	0.996	0.000
Q84.0 Congenital alopecia	0.004	0.996	0.000
Q86.8 Other congenital malformation syndromes due to known exogenous causes	0.004	0.996	0.000
Q86.2 Dysmorphism due to warfarin	0.004	0.996	0.000
Q86.1 Foetal hydantoin syndrome	0.004	0.996	0.000
Q86.0 Foetal alcohol syndrome (dysmorphic)	0.004	0.996	0.000
T46 Poisoning by agents primarily affecting the cardiovascular system	0.004	0.996	0.000
Z62 Other problems related to upbringing	0.004	0.996	0.000
Z55 Problems related to education and literacy	0.004	0.996	0.000
Z59.0 Homelessness	0.004	0.996	0.000
S34 Injury of nerves and lumbar spinal cord at abdomen, lower back and pelvis level	0.004	0.996	0.000
F45.4 Persistent somatoform pain disorder	0.004	0.996	0.000
S92.50 Fracture of other toe (closed)	0.004	0.996	0.000
F45.0 Somatisation disorder	0.004	0.996	0.000
S36.4 Injury of small intestine	0.004	0.996	0.000
S37.0 Injury of kidney	0.004	0.996	0.000
T46.4 Angiotensin-converting-enzyme inhibitors	0.004	0.996	0.000
T43.1 Monoamine-oxidase-inhibitor antidepressants	0.004	0.996	0.000
M89.04 Algoneurodystrophy (Hand)	0.000	0.996	0.004
S36.9 Injury of unspecified intra-abdominal organ	0.004	0.996	0.000
S36.7 Injury of multiple intra-abdominal organs	0.004	0.996	0.000
S36.6 Injury of rectum	0.004	0.996	0.000
S36.3 Injury of stomach	0.004	0.996	0.000
S36.2 Injury of pancreas	0.004	0.996	0.000
T41 Poisoning by anaesthetics and therapeutic gases	0.004	0.996	0.000
T37.2 Antimalarials and drugs acting on other blood protozoa	0.004	0.996	0.000
T43.8 Other psychotropic drugs, not elsewhere classified	0.004	0.996	0.000
S38 Crushing injury and traumatic amputation of part of abdomen, lower back and pelvis	0.004	0.996	0.000
T45.2 Vitamins, not elsewhere classified	0.004	0.996	0.000
S30.8 Other superficial injuries of abdomen, lower back and pelvis	0.004	0.996	0.000
T44.3 Other parasympatholytics [anticholinergics and antimuscarines] and spasmolytics, not elsewhere classified	0.004	0.996	0.000
Z59.7 Insufficient social insurance and welfare support	0.004	0.996	0.000
Z59.6 Low income	0.004	0.996	0.000
Z59.5 Extreme poverty	0.004	0.996	0.000
Z59.3 Problems related to living in residential institution	0.004	0.996	0.000
M89.81 Other specified disorders of bone (Shoulder region)	0.000	0.996	0.004
Z58.7 Exposure to tobacco smoke	0.004	0.996	0.000
S36.80 Injury of other intra-abdominal organs (without open wound into cavity)	0.004	0.996	0.000
F32.8 Other depressive episodes	0.004	0.996	0.000
Q85.9 Phakomatosis, unspecified	0.004	0.996	0.000
F45.2 Hypochondriacal disorder	0.004	0.996	0.000
T43.6 Psychostimulants with abuse potential	0.004	0.996	0.000
T44.6 Alpha-Adrenoreceeptor antagonists, not elsewhere classified	0.004	0.996	0.000
Z59.4 Lack of adequate food	0.004	0.996	0.000
S36.00 Injury of spleen (without open wound into cavity)	0.004	0.996	0.000
S37.00 Injury of kidney (without open wound into cavity)	0.004	0.996	0.000
N13.8 Other obstructive and reflux uropathy	0.004	0.996	0.000
Z59.1 Inadequate housing	0.004	0.996	0.000
S39 Other and unspecified injuries of abdomen, lower back and pelvis	0.004	0.996	0.000
T36.1 Cefalosporins and other Beta-lactam antibiotics	0.004	0.996	0.000
Z58.9 Problem related to physical environment, unspecified	0.004	0.996	0.000
Z58.6 Inadequate drinking-water supply	0.004	0.996	0.000
Z58.4 Exposure to radiation	0.004	0.996	0.000
Z58.3 Exposure to soil pollution	0.004	0.996	0.000
Z58.2 Exposure to water pollution	0.004	0.996	0.000
Z58.0 Exposure to noise	0.004	0.996	0.000
Z57.9 Occupational exposure to unspecified risk-factor	0.004	0.996	0.000
Z57.7 Occupational exposure to vibration	0.004	0.996	0.000
Z57.6 Occupational exposure to extreme temperature	0.004	0.996	0.000
Z57.4 Occupational exposure to toxic agents in agriculture	0.004	0.996	0.000
Z57.1 Occupational exposure to radiation	0.004	0.996	0.000
Z57.0 Occupational exposure to noise	0.004	0.996	0.000
M89 Other disorders of bone	0.000	0.996	0.004
Z59.8 Other problems relating to housing and economic circumstances	0.004	0.996	0.000
S36.10 Injury of liver or gallbladder (without open wound into cavity)	0.004	0.996	0.000
S36.50 Injury of colon (without open wound into cavity)	0.004	0.996	0.000
S92.90 Fracture of foot, unspecified (closed)	0.003	0.996	0.000
M89.07 Algoneurodystrophy (Ankle and foot)	0.000	0.996	0.004
T45.4 Iron and its compounds	0.004	0.996	0.000
T37.9 Systemic anti-infective and antiparasitic, unspecified	0.004	0.996	0.000
T37.5 Antiviral drugs	0.004	0.996	0.000
T37.4 Anthelminthics	0.004	0.996	0.000
T37.3 Other antiprotozoal drugs	0.004	0.996	0.000
T37.1 Antimycobacterial drugs	0.004	0.996	0.000
T37.0 Sulphonamides	0.004	0.996	0.000
Z57.8 Occupational exposure to other risk-factors	0.004	0.996	0.000
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs	0.004	0.996	0.000
Z56 Problems related to employment and unemployment	0.004	0.996	0.000
M96.9 Postprocedural musculoskeletal disorder, unspecified	0.000	0.996	0.004
T46.1 Calcium-channel blockers	0.004	0.996	0.000
N13.4 Hydroureter	0.004	0.996	0.000
M25.77 Osteophyte (Ankle and foot)	0.000	0.996	0.004
Q85.1 Tuberous sclerosis	0.004	0.996	0.000
T36.4 Tetracyclines	0.004	0.996	0.000
T43.4 Butyrophenone and thioxanthene neuroleptics	0.004	0.996	0.000
M96.8 Other postprocedural musculoskeletal disorders	0.000	0.996	0.004
Q82.8 Other specified congenital malformations of skin	0.004	0.996	0.000
S33.2 Dislocation of sacro-iliac and sacrococcygeal joint	0.004	0.996	0.000
M48.07 Spinal stenosis (Lumbosacral region)	0.004	0.996	0.000
M89.09 Algoneurodystrophy (Site unspecified)	0.000	0.996	0.004
M89.88 Other specified disorders of bone (Other)	0.000	0.996	0.004
F45.1 Undifferentiated somatoform disorder	0.004	0.996	0.000
T47.4 Other laxatives	0.004	0.996	0.000
M89.06 Algoneurodystrophy (Lower leg)	0.000	0.996	0.004
I49.0 Ventricular fibrillation and flutter	0.004	0.996	0.000
T45.9 Primarily systemic and haematological agent, unspecified	0.004	0.996	0.000
T45.8 Other primarily systemic and haematological agents	0.004	0.996	0.000
T45.7 Anticoagulant antagonists, vitamin K and other coagulants	0.004	0.996	0.000
T45.6 Fibrinolysis-affecting drugs	0.004	0.996	0.000
T45.3 Enzymes, not elsewhere classified	0.004	0.996	0.000
Z63.0 Problems in relationship with spouse or partner	0.004	0.996	0.000
S35.2 Injury of coeliac or mesenteric artery	0.003	0.996	0.000
S39.8 Other specified injuries of abdomen, lower back and pelvis	0.004	0.996	0.000
T43.9 Psychotropic drug, unspecified	0.003	0.996	0.000
S90-S99 Injuries to the ankle and foot	0.004	0.996	0.000
S37.3 Injury of urethra	0.003	0.996	0.000
Z57.3 Occupational exposure to other air contaminants	0.004	0.996	0.000
Z58.8 Other problems related to physical environment	0.003	0.996	0.000
Q85.8 Other phakomatoses, not elsewhere classified	0.003	0.996	0.000
T36.8 Other systemic antibiotics	0.003	0.996	0.000
F45.9 Somatoform disorder, unspecified	0.003	0.996	0.000
T47.1 Other antacids and anti-gastric-secretion drugs	0.003	0.996	0.000
Z60 Problems related to social environment	0.004	0.996	0.000
T36.3 Macrolides	0.003	0.996	0.000
Z65.8 Other specified problems related to psychosocial circumstances	0.003	0.996	0.000
M89.89 Other specified disorders of bone (Site unspecified)	0.000	0.996	0.003
K10.2 Inflammatory conditions of jaws	0.004	0.996	0.000
S33.1 Dislocation of lumbar vertebra	0.003	0.996	0.000
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system	0.003	0.996	0.000
S36.01 Injury of spleen (with open wound into cavity)	0.003	0.996	0.000
S36.81 Injury of other intra-abdominal organs (with open wound into cavity)	0.003	0.996	0.000
S30.7 Multiple superficial injuries of abdomen, lower back and pelvis	0.003	0.996	0.000
T36.9 Systemic antibiotic, unspecified	0.003	0.996	0.000
T36.7 Antifungal antibiotics, systemically used	0.003	0.996	0.000
T36.6 Rifamycins	0.003	0.996	0.000
T36.5 Aminoglycosides	0.003	0.996	0.000
T36.2 Chloramphenicol group	0.003	0.996	0.000
S37.9 Injury of unspecified pelvic organ	0.003	0.997	0.000
S37.8 Injury of other pelvic organs	0.003	0.997	0.000
S37.7 Injury of multiple pelvic organs	0.003	0.997	0.000
S37.6 Injury of uterus	0.003	0.997	0.000
S37.5 Injury of Fallopian tube	0.003	0.997	0.000
S37.4 Injury of ovary	0.003	0.997	0.000
S37.1 Injury of ureter	0.003	0.997	0.000
M89.82 Other specified disorders of bone (Upper arm)	0.000	0.997	0.003
M89.80 Other specified disorders of bone (Multiple sites)	0.000	0.997	0.003
S36.11 Injury of liver or gallbladder (with open wound into cavity)	0.003	0.997	0.000
S33.5 Sprain and strain of lumbar spine	0.003	0.997	0.000
S93 Dislocation, sprain and strain of joints and ligaments at ankle and foot level	0.003	0.997	0.000
S36.51 Injury of colon (with open wound into cavity)	0.003	0.997	0.000
M89.3 Hypertrophy of bone	0.000	0.997	0.003
T45.0 Antiallergic and antiemetic drugs	0.003	0.997	0.000
S33.7 Sprain and strain of other and unspecified parts of lumbar spine and pelvis	0.003	0.997	0.000
S33.6 Sprain and strain of sacro-iliac joint	0.003	0.997	0.000
S33.4 Traumatic rupture of symphysis pubis	0.003	0.997	0.000
S33.3 Dislocation of other and unspecified parts of lumbar spine and pelvis	0.003	0.997	0.000
S33.0 Traumatic rupture of lumbar intervertebral disk	0.003	0.997	0.000
T45.5 Anticoagulants	0.003	0.997	0.000
Z64 Problems related to certain psychosocial circumstances	0.003	0.997	0.000
T47.2 Stimulant laxatives	0.003	0.997	0.000
S36.40 Injury of small intestine (without open wound into cavity)	0.003	0.997	0.000
T47.9 Agent primarily affecting the gastro-intestinal system, unspecified	0.003	0.997	0.000
T47.8 Other agents primarily affecting the gastro-intestinal system	0.003	0.997	0.000
T47.7 Emetics	0.003	0.997	0.000
T47.5 Digestants	0.003	0.997	0.000
T47.3 Saline and osmotic laxatives	0.003	0.997	0.000
M89.08 Algoneurodystrophy (Other)	0.000	0.997	0.003
M89.05 Algoneurodystrophy (Pelvic region and thigh)	0.000	0.997	0.003
M89.02 Algoneurodystrophy (Upper arm)	0.000	0.997	0.003
C02.9 Tongue, unspecified	0.003	0.997	0.000
S32.0 Fracture of lumbar vertebra	0.001	0.997	0.002
S34.2 Injury of nerve root of lumbar and sacral spine	0.003	0.997	0.000
S34.1 Other injury of lumbar spinal cord	0.003	0.997	0.000
T47.0 Histamine H(2)-receptor antagonists	0.003	0.997	0.000
M96.65 Fracture of pelvis following insertion of orthopedic implant, joint prosthesis, or bone plate (Fx pelvis following insrt ortho implnt/prosth/bone plt)	0.000	0.997	0.003
M96.63 Fracture of radius or ulna following insertion of orthopedic implant, joint prosthesis, or bone plate	0.000	0.997	0.003
S35.9 Injury of unspecified blood vessel at abdomen, lower back and pelvis level	0.003	0.997	0.000
S35.8 Injury of other blood vessels at abdomen, lower back and pelvis level	0.003	0.997	0.000
S35.7 Injury of multiple blood vessels at abdomen, lower back and pelvis level	0.003	0.997	0.000
S35.5 Injury of iliac blood vessels	0.003	0.997	0.000
S35.4 Injury of renal blood vessels	0.003	0.997	0.000
S35.3 Injury of portal or splenic vein	0.003	0.997	0.000
S35.1 Injury of inferior vena cava	0.003	0.997	0.000
S35.0 Injury of abdominal aorta	0.003	0.997	0.000
N13 Obstructive and reflux uropathy	0.003	0.997	0.000
M89.00 Algoneurodystrophy (Multiple sites)	0.000	0.997	0.003
F33.1 Recurrent depressive disorder, current episode moderate	0.003	0.997	0.000
N13.1 Hydronephrosis with ureteral stricture, not elsewhere classified	0.003	0.997	0.000
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs	0.003	0.997	0.000
Z65.3 Problems related to other legal circumstances	0.003	0.997	0.000
Z60.8 Other problems related to social environment	0.003	0.997	0.000
Z65.5 Exposure to disaster, war and other hostilities	0.003	0.997	0.000
Z65.4 Victim of crime and terrorism	0.003	0.997	0.000
Z65.2 Problems related to release from prison	0.003	0.997	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations