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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs220299
log Bayes Factor = 0.00177075
Chromosome 21   position 43,502,762  (GRCh37) Explore rs220299 on Ensembl!
Variant rs220299 is listed in the   GWAS Catalog   ⇪

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E27 Other disorders of adrenal gland
0.178 0.822 0.000
E20-E35 Disorders of other endocrine glands
0.177 0.823 0.000
E27.2 Addisonian crisis
0.171 0.829 0.000
E24 Cushing's syndrome
0.171 0.829 0.000
E27.1 Primary adrenocortical insufficiency
0.171 0.829 0.000
E22 Hyperfunction of pituitary gland
0.167 0.833 0.000
E24.9 Cushing's syndrome, unspecified
0.160 0.840 0.000
E26 Hyperaldosteronism
0.160 0.840 0.000
E22.0 Acromegaly and pituitary gigantism
0.157 0.843 0.000
E24.0 Pituitary-dependent Cushing's disease
0.152 0.848 0.000
E27.3 Drug-induced adrenocortical insufficiency
0.146 0.854 0.000
E26.0 Primary hyperaldosteronism
0.146 0.854 0.000
E34 Other endocrine disorders
0.142 0.858 0.000
E23 Hypofunction and other disorders of pituitary gland
0.140 0.860 0.000
E23.2 Diabetes insipidus
0.131 0.869 0.000
E22.1 Hyperprolactinaemia
0.130 0.870 0.000
E29 Testicular dysfunction
0.130 0.870 0.000
E22.9 Hyperfunction of pituitary gland, unspecified
0.129 0.870 0.000
E32 Diseases of thymus
0.129 0.871 0.000
E27.5 Adrenomedullary hyperfunction
0.128 0.872 0.000
E27.0 Other adrenocortical overactivity
0.128 0.872 0.000
E35 Disorders of endocrine glands in diseases classified elsewhere
0.127 0.873 0.000
E30 Disorders of puberty, not elsewhere classified
0.127 0.873 0.000
E25 Adrenogenital disorders
0.126 0.874 0.000
E31 Polyglandular dysfunction
0.126 0.874 0.000
E24.2 Drug-induced Cushing's syndrome
0.125 0.875 0.000
E27.4 Other and unspecified adrenocortical insufficiency
0.125 0.875 0.000
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.123 0.877 0.000
E24.3 Ectopic ACTH syndrome
0.123 0.877 0.000
E24.1 Nelson's syndrome
0.123 0.877 0.000
E22.8 Other hyperfunction of pituitary gland
0.120 0.880 0.000
E26.9 Hyperaldosteronism, unspecified
0.119 0.880 0.000
E24.8 Other Cushing's syndrome
0.119 0.881 0.000
E27.8 Other specified disorders of adrenal gland
0.118 0.882 0.000
E34.0 Carcinoid syndrome
0.115 0.885 0.000
E26.8 Other hyperaldosteronism
0.115 0.885 0.000
E26.1 Secondary hyperaldosteronism
0.115 0.885 0.000
E20 Hypoparathyroidism
0.113 0.887 0.000
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.113 0.887 0.000
E34.3 Short stature, not elsewhere classified
0.111 0.889 0.000
E28 Ovarian dysfunction
0.108 0.892 0.000
E34.8 Other specified endocrine disorders
0.106 0.894 0.000
E34.5 Androgen resistance syndrome
0.102 0.898 0.000
E34.4 Constitutional tall stature
0.102 0.898 0.000
E34.2 Ectopic hormone secretion, not elsewhere classified
0.102 0.898 0.000
E34.1 Other hypersecretion of intestinal hormones
0.102 0.898 0.000
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.102 0.898 0.000
E27.9 Disorder of adrenal gland, unspecified
0.101 0.899 0.000
E23.1 Drug-induced hypopituitarism
0.100 0.900 0.000
E29.9 Testicular dysfunction, unspecified
0.099 0.901 0.000
E32.8 Other diseases of thymus
0.094 0.906 0.000
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.094 0.906 0.000
E29.8 Other testicular dysfunction
0.093 0.907 0.000
E29.0 Testicular hyperfunction
0.093 0.907 0.000
E32.9 Disease of thymus, unspecified
0.092 0.907 0.000
E32.1 Abscess of thymus
0.092 0.907 0.000
E32.0 Persistent hyperplasia of thymus
0.092 0.907 0.000
E30.9 Disorder of puberty, unspecified
0.091 0.909 0.000
E30.8 Other disorders of puberty
0.091 0.909 0.000
E30.1 Precocious puberty
0.091 0.909 0.000
E30.0 Delayed puberty
0.091 0.909 0.000
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.091 0.909 0.000
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.091 0.909 0.000
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.091 0.909 0.000
E34.9 Endocrine disorder, unspecified
0.091 0.909 0.000
E25.9 Adrenogenital disorder, unspecified
0.091 0.909 0.000
E25.8 Other adrenogenital disorders
0.091 0.909 0.000
E31.9 Polyglandular dysfunction, unspecified
0.091 0.909 0.000
E31.8 Other polyglandular dysfunction
0.091 0.909 0.000
E31.1 Polyglandular hyperfunction
0.091 0.909 0.000
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.090 0.910 0.000
E31.0 Autoimmune polyglandular failure
0.090 0.910 0.000
E29.1 Testicular hypofunction
0.089 0.911 0.000
E23.0 Hypopituitarism
0.086 0.914 0.000
E28.3 Primary ovarian failure
0.084 0.916 0.000
E23.7 Disorder of pituitary gland, unspecified
0.082 0.918 0.000
E20.1 Pseudohypoparathyroidism
0.081 0.919 0.000
E20.0 Idiopathic hypoparathyroidism
0.081 0.919 0.000
E23.6 Other disorders of pituitary gland
0.081 0.919 0.000
E28.9 Ovarian dysfunction, unspecified
0.077 0.923 0.000
E28.8 Other ovarian dysfunction
0.077 0.923 0.000
E28.1 Androgen excess
0.077 0.923 0.000
E28.0 Oestrogen excess
0.077 0.923 0.000
E20.8 Other hypoparathyroidism
0.076 0.924 0.000
E20.9 Hypoparathyroidism, unspecified
0.073 0.927 0.000
E21.3 Hyperparathyroidism, unspecified
0.070 0.930 0.000
E21.4 Other specified disorders of parathyroid gland
0.069 0.930 0.000
E21.2 Other hyperparathyroidism
0.067 0.933 0.000
E21.5 Disorder of parathyroid gland, unspecified
0.066 0.934 0.000
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.054 0.945 0.000
E21.0 Primary hyperparathyroidism
0.047 0.953 0.000
E28.2 Polycystic ovarian syndrome
0.045 0.955 0.000
M46.92 Inflammatory spondylopathy, unspecified (Cervical region)
0.018 0.982 0.000
S82.10 Fracture of upper end of tibia (closed)
0.016 0.984 0.000
M46.9 Inflammatory spondylopathy, unspecified
0.014 0.986 0.000
M46.97 Inflammatory spondylopathy, unspecified (Lumbosacral region)
0.014 0.986 0.000
S83.5 Sprain and strain involving (anterior)(posterior) cruciate ligament of knee
0.013 0.987 0.000
E11.5 With peripheral circulatory complications
0.013 0.987 0.000
K83.0 Cholangitis
0.013 0.987 0.000
E11 Non-insulin-dependent diabetes mellitus
0.012 0.988 0.000
E11.6 With other specified complications
0.012 0.988 0.000
E11.3 With ophthalmic complications
0.012 0.988 0.000
S83.6 Sprain and strain of other and unspecified parts of knee
0.012 0.988 0.000
S83 Dislocation, sprain and strain of joints and ligaments of knee
0.011 0.989 0.000
M46.90 Inflammatory spondylopathy, unspecified (Multiple sites in spine)
0.011 0.989 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.011 0.989 0.000
E10-E14 Diabetes mellitus
0.011 0.989 0.000
S82.1 Fracture of upper end of tibia
0.011 0.989 0.000
M46.99 Inflammatory spondylopathy, unspecified (Site unspecified)
0.011 0.989 0.000
M46.95 Inflammatory spondylopathy, unspecified (Thoracolumbar region)
0.010 0.989 0.000
M46.94 Inflammatory spondylopathy, unspecified (Thoracic region)
0.010 0.989 0.000
M46.93 Inflammatory spondylopathy, unspecified (Cervicothoracic region)
0.010 0.989 0.000
M46.91 Inflammatory spondylopathy, unspecified (Occipito-atlanto-axial region)
0.010 0.989 0.000
M46.98 Inflammatory spondylopathy, unspecified (Sacral and sacrococcygeal region)
0.010 0.990 0.000
M46.96 Inflammatory spondylopathy, unspecified (Lumbar region)
0.010 0.990 0.000
E11.1 With ketoacidosis
0.010 0.990 0.000
E11.4 With neurological complications
0.010 0.990 0.000
I84.5 External haemorrhoids without complication
0.010 0.990 0.000
S82.11 Fracture of upper end of tibia (open)
0.009 0.991 0.000
E11.7 With multiple complications
0.009 0.991 0.000
S83.4 Sprain and strain involving (fibular)(tibial) collateral ligamnent of knee
0.009 0.991 0.000
S83.3 Tear of articular cartilage of knee, current
0.008 0.991 0.000
S83.1 Dislocation of knee
0.008 0.992 0.000
E65-E68 Obesity and other hyperalimentation
0.008 0.992 0.000
E65 Localised adiposity
0.008 0.992 0.000
E11.0 With coma
0.008 0.992 0.000
E12 Malnutrition-related diabetes mellitus
0.008 0.992 0.000
E10 Insulin-dependent diabetes mellitus
0.008 0.992 0.000
S83.0 Dislocation of patella
0.008 0.992 0.000
E11.2 With renal complications
0.008 0.992 0.000
K83 Other diseases of biliary tract
0.008 0.992 0.000
E40-E46 Malnutrition
0.008 0.992 0.000
E13 Other specified diabetes mellitus
0.008 0.992 0.000
K83.1 Obstruction of bile duct
0.008 0.992 0.000
F32.1 Moderate depressive episode
0.007 0.993 0.000
E10.3 With ophthalmic complications
0.007 0.993 0.000
S80-S89 Injuries to the knee and lower leg
0.007 0.993 0.000
K83.3 Fistula of bile duct
0.007 0.993 0.000
I35.1 Aortic (valve) insufficiency
0.000 0.993 0.007
E10.5 With peripheral circulatory complications
0.007 0.993 0.000
S89 Other and unspecified injuries of lower leg
0.007 0.993 0.000
E10.7 With multiple complications
0.007 0.993 0.000
E11.8 With unspecified complications
0.006 0.993 0.000
F32.0 Mild depressive episode
0.007 0.993 0.000
F32 Depressive episode
0.007 0.993 0.000
S89.9 Unspecified injury of lower leg
0.006 0.993 0.000
K83.4 Spasm of sphincter of Oddi
0.006 0.994 0.000
E13.9 Without complications
0.006 0.994 0.000
E67 Other hyperalimentation
0.006 0.994 0.000
E68 Sequelae of hyperalimentation
0.006 0.994 0.000
S81 Open wound of lower leg
0.006 0.994 0.000
E10.4 With neurological complications
0.006 0.994 0.000
E10.0 With coma
0.006 0.994 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.006 0.994 0.000
E10.2 With renal complications
0.006 0.994 0.000
E12.9 Without complications
0.006 0.994 0.000
E12.8 With unspecified complications
0.006 0.994 0.000
E12.7 With multiple complications
0.006 0.994 0.000
E12.6 With other specified complications
0.006 0.994 0.000
E12.5 With peripheral circulatory complications
0.006 0.994 0.000
E12.4 With neurological complications
0.006 0.994 0.000
E12.3 With ophthalmic complications
0.006 0.994 0.000
E12.2 With renal complications
0.006 0.994 0.000
E12.1 With ketoacidosis
0.006 0.994 0.000
E12.0 With coma
0.006 0.994 0.000
F10.0 Acute intoxication
0.006 0.994 0.000
T44.7 Beta-Adrenoreceeptor antagonists, not elsewhere classified
0.006 0.994 0.000
E44 Protein-energy malnutrition of moderate and mild degree
0.006 0.994 0.000
E45 Retarded development following protein-energy malnutrition
0.006 0.994 0.000
E43 Unspecified severe protein-energy malnutrition
0.006 0.994 0.000
E42 Marasmic kwashiorkor
0.006 0.994 0.000
E41 Nutritional marasmus
0.006 0.994 0.000
E40 Kwashiorkor
0.006 0.994 0.000
E10.1 With ketoacidosis
0.006 0.994 0.000
E13.8 With unspecified complications
0.006 0.994 0.000
E13.7 With multiple complications
0.006 0.994 0.000
E13.6 With other specified complications
0.006 0.994 0.000
E13.5 With peripheral circulatory complications
0.006 0.994 0.000
E13.4 With neurological complications
0.006 0.994 0.000
E13.2 With renal complications
0.006 0.994 0.000
E13.1 With ketoacidosis
0.006 0.994 0.000
E13.0 With coma
0.006 0.994 0.000
S87 Crushing injury of lower leg
0.006 0.994 0.000
T46 Poisoning by agents primarily affecting the cardiovascular system
0.006 0.994 0.000
T50.9 Other and unspecified drugs, medicaments and biological substances
0.006 0.994 0.000
E46 Unspecified protein-energy malnutrition
0.006 0.994 0.000
T46.1 Calcium-channel blockers
0.006 0.994 0.000
K83.2 Perforation of bile duct
0.005 0.994 0.000
S83.7 Injury to multiple structures of knee
0.005 0.994 0.000
E10.8 With unspecified complications
0.005 0.994 0.000
K83.5 Biliary cyst
0.005 0.994 0.000
F32.2 Severe depressive episode without psychotic symptoms
0.006 0.994 0.000
T44 Poisoning by drugs primarily affecting the autonomic nervous system
0.005 0.994 0.000
S83.2 Tear of meniscus, current
0.005 0.995 0.000
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances
0.005 0.995 0.000
S88 Traumatic amputation of lower leg
0.005 0.995 0.000
S85 Injury of blood vessels at lower leg level
0.005 0.995 0.000
W19.2 School, other institution and public administrative area
0.005 0.995 0.000
T43.0 Tricyclic and tetracyclic antidepressants
0.005 0.995 0.000
S84 Injury of nerves at lower leg level
0.005 0.995 0.000
M00.96 Pyogenic arthritis, unspecified (Lower leg)
0.005 0.995 0.000
T46.6 Antihyperlipidaemic and antiarteriosclerotic drugs
0.005 0.995 0.000
T36-T50 Poisoning by drugs, medicaments and biological substances
0.005 0.995 0.000
S81.9 Open wound of lower leg, part unspecified
0.005 0.995 0.000
T46.9 Other and unspecified agents primarily affecting the cardiovascular system
0.005 0.995 0.000
S81.8 Open wound of other parts of lower leg
0.005 0.995 0.000
F30-F39 Mood [affective] disorders
0.005 0.995 0.000
S87.8 Crushing injury of other and unspecified parts of lower leg
0.005 0.995 0.000
F32.8 Other depressive episodes
0.005 0.995 0.000
K83.9 Disease of biliary tract, unspecified
0.005 0.995 0.000
F31 Bipolar affective disorder
0.005 0.995 0.000
S89.7 Multiple injuries of lower leg
0.005 0.995 0.000
S89.1 Other specified injuries of lower leg
0.005 0.995 0.000
S89.0 Multiple injuries of lower leg
0.005 0.995 0.000
T44.3 Other parasympatholytics [anticholinergics and antimuscarines] and spasmolytics, not elsewhere classified
0.005 0.995 0.000
E13.3 With ophthalmic complications
0.005 0.995 0.000
E14 Unspecified diabetes mellitus
0.005 0.995 0.000
S82 Fracture of lower leg, including ankle
0.005 0.995 0.000
T46.5 Other antihypertensive drugs, not elsewhere classified
0.005 0.995 0.000
F31.4 Bipolar affective disorder, current episode severe depression without psychotic symptoms
0.005 0.995 0.000
S89.8 Other specified injuries of lower leg
0.005 0.995 0.000
S81.7 Multiple open wounds of lower leg
0.005 0.995 0.000
F32.3 Severe depressive episode with psychotic symptoms
0.005 0.995 0.000
S81.0 Open wound of knee
0.005 0.995 0.000
T46.3 Coronary vasodilators, not elsewhere classified
0.005 0.995 0.000
S72.10 Pertrochanteric fracture (closed)
0.000 0.995 0.005
E67.8 Other specified hyperalimentation
0.005 0.995 0.000
E67.3 Hypervitaminosis D
0.005 0.995 0.000
E67.2 Megavitamin-B6 syndrome
0.005 0.995 0.000
E67.1 Hypercarotenaemia
0.005 0.995 0.000
E67.0 Hypervitaminosis A
0.005 0.995 0.000
M00.9 Pyogenic arthritis, unspecified
0.005 0.995 0.000
F31.9 Bipolar affective disorder, unspecified
0.005 0.995 0.000
T43 Poisoning by psychotropic drugs, not elsewhere classified
0.005 0.995 0.000
T36 Poisoning by systemic antibiotics
0.005 0.995 0.000
E15 Nondiabetic hypoglycaemic coma
0.004 0.995 0.000
T50.2 Carbonic-anhydrase inhibitors, benzothiadiazides and other diuretics
0.005 0.995 0.000
T50.1 Loop [high-ceiling] diuretics
0.005 0.995 0.000
T43.4 Butyrophenone and thioxanthene neuroleptics
0.005 0.995 0.000
W22.9 Unspecified place
0.005 0.995 0.000
F34 Persistent mood [affective] disorders
0.005 0.995 0.000
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified
0.005 0.995 0.000
E44.1 Mild protein-energy malnutrition
0.004 0.995 0.000
E44.0 Moderate protein-energy malnutrition
0.004 0.995 0.000
M00.91 Pyogenic arthritis, unspecified (Shoulder region)
0.004 0.995 0.000
S87.0 Crushing injury of knee
0.004 0.995 0.000
A04.5 Campylobacter enteritis
0.000 0.995 0.005
T37 Poisoning by other systemic anti-infectives and antiparasitics
0.004 0.995 0.000
T46.8 Antivaricose drugs, including sclerosing agents
0.004 0.995 0.000
T46.7 Peripheral vasodilators
0.004 0.995 0.000
S86 Injury of muscle and tendon at lower leg level
0.004 0.996 0.000
F31.0 Bipolar affective disorder, current episode hypomanic
0.004 0.996 0.000
T46.0 Cardiac-stimulant glycosides and drugs of similar action
0.004 0.996 0.000
S62.80 Fracture of other and unspecified parts of wrist and hand (closed)
0.004 0.996 0.000
E10.6 With other specified complications
0.004 0.996 0.000
E14.1 With ketoacidosis
0.004 0.996 0.000
T41 Poisoning by anaesthetics and therapeutic gases
0.004 0.996 0.000
I78.1 Naevus, nonneoplastic
0.000 0.996 0.004
T36.4 Tetracyclines
0.004 0.996 0.000
T44.8 Centrally acting and afrenergic-neuron-blocking agents, not elsewhere classified
0.004 0.996 0.000
T44.5 Predominantly Beta-adrenoreceptor agonists, not elsewhere classified
0.004 0.996 0.000
T44.4 Predominantly Alpha-adrenoreceptor agonists, not elsewhere classified
0.004 0.996 0.000
T44.2 Ganglionic blocking drugs, not elsewhere classified
0.004 0.996 0.000
T44.1 Other parasympathomimetics [cholinergics]
0.004 0.996 0.000
T44.0 Anticholinesterase agents
0.004 0.996 0.000
T46.2 Other antidysrhythmic drugs, not elsewhere classified
0.004 0.996 0.000
T50.7 Analeptics and opioid receptor antagonists
0.004 0.996 0.000
T50.5 Appetite depressants
0.004 0.996 0.000
T50.3 Electrolytic, caloric and water-balance agents
0.004 0.996 0.000
T50.0 Mineralocorticoids and their antagonists
0.004 0.996 0.000
E14.2 Withrenal complications
0.004 0.996 0.000
K83.8 Other specified diseases of biliary tract
0.004 0.996 0.000
T45.0 Antiallergic and antiemetic drugs
0.004 0.996 0.000
T43.3 Phenothiazine antipsychotics and neuroleptics
0.004 0.996 0.000
E14.6 With other specified complications
0.004 0.996 0.000
S86.9 Injury of unspecified muscle and tendon at lower leg level
0.004 0.996 0.000
S85.9 Injury of unspecified blood vessel at lower leg level
0.004 0.996 0.000
S85.8 Injury of other blood vessels at lower leg level
0.004 0.996 0.000
S85.7 Injury of multiple blood vessels at lower leg level
0.004 0.996 0.000
S85.5 Injury of popliteal vein
0.004 0.996 0.000
S85.4 Injury of lesser saphenous vein at lower leg level
0.004 0.996 0.000
S85.3 Injury of greater saphenous vein at lower leg level
0.004 0.996 0.000
S85.2 Injury of peroneal artery
0.004 0.996 0.000
S85.1 Injury of (anterior)(posterior) tibial artery
0.004 0.996 0.000
S85.0 Injury of popliteal artery
0.004 0.996 0.000
S88.9 Traumatic amputation of lower leg, level unspecified
0.004 0.996 0.000
S88.1 Traumatic amputation at level between knee and ankle
0.004 0.996 0.000
S88.0 Traumatic amputation at knee level
0.004 0.996 0.000
F31.3 Bipolar affective disorder, current episode mild or moderate depression
0.004 0.996 0.000
F31.7 Bipolar affective disorder, currently in remission
0.004 0.996 0.000
S84.9 Injury of unspecified nerve at lower leg level
0.004 0.996 0.000
S84.8 Injury of other nerves at lower leg level
0.004 0.996 0.000
S84.7 Injury of multiple nerves at lower leg level
0.004 0.996 0.000
S84.2 Injury of cutaneous sensory nerve at lower leg level
0.004 0.996 0.000
S84.0 Injury of tibial nerve at lower leg level
0.004 0.996 0.000
T50.8 Diagnostic agents
0.004 0.996 0.000
M00.92 Pyogenic arthritis, unspecified (Upper arm)
0.004 0.996 0.000
T36.3 Macrolides
0.004 0.996 0.000
T47 Poisoning by agents primarily affecting gastro-intestinal system
0.004 0.996 0.000
S80 Superficial injury of lower leg
0.004 0.996 0.000
F34.0 Cyclothymia
0.004 0.996 0.000
S84.1 Injury of peroneal nerve at lower leg level
0.004 0.996 0.000
F30 Manic episode
0.004 0.996 0.000
M00.95 Pyogenic arthritis, unspecified (Pelvic region and thigh)
0.004 0.996 0.000
T37.8 Other specified systemic anti-infectives and antiparasitics
0.004 0.996 0.000
T44.9 Other and unspecified drugs primarily affecting the nervous system
0.004 0.996 0.000
T50.4 Drugs affecting uric acid metabolism
0.004 0.996 0.000
F38 Other mood [affective] disorders
0.004 0.996 0.000
C25.9 Pancreas, unspecified
0.000 0.996 0.004
T36.1 Cefalosporins and other Beta-lactam antibiotics
0.004 0.996 0.000
E14.7 With multiple complications
0.004 0.996 0.000
E14.0 With coma
0.004 0.996 0.000
F34.1 Dysthymia
0.004 0.996 0.000
T46.4 Angiotensin-converting-enzyme inhibitors
0.004 0.996 0.000
E14.4 With neurological complications
0.004 0.996 0.000
F31.6 Bipolar affective disorder, current episode mixed
0.004 0.996 0.000
M46 Other inflammatory spondylopathies
0.004 0.996 0.000
T36.8 Other systemic antibiotics
0.004 0.996 0.000
F33 Recurrent depressive disorder
0.004 0.996 0.000
T43.1 Monoamine-oxidase-inhibitor antidepressants
0.004 0.996 0.000
T45.1 Antineoplastic and immunosuppressive drugs
0.004 0.996 0.000
F31.8 Other bipolar affective disorders
0.004 0.996 0.000
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs
0.004 0.996 0.000
F39 Unspecified mood [affective] disorder
0.004 0.996 0.000
M00.98 Pyogenic arthritis, unspecified (Other)
0.004 0.996 0.000
M00.97 Pyogenic arthritis, unspecified (Ankle and foot)
0.004 0.996 0.000
T36.9 Systemic antibiotic, unspecified
0.004 0.996 0.000
T36.7 Antifungal antibiotics, systemically used
0.004 0.996 0.000
T36.6 Rifamycins
0.004 0.996 0.000
T36.5 Aminoglycosides
0.004 0.996 0.000
T36.2 Chloramphenicol group
0.004 0.996 0.000
T43.8 Other psychotropic drugs, not elsewhere classified
0.004 0.996 0.000
M00.99 Pyogenic arthritis, unspecified (Site unspecified)
0.004 0.996 0.000
S82.7 Multiple fractures of lower leg
0.004 0.996 0.000
T41.2 Other and unspecified general anaesthetics
0.003 0.996 0.000
T37.2 Antimalarials and drugs acting on other blood protozoa
0.003 0.996 0.000
T45.2 Vitamins, not elsewhere classified
0.004 0.996 0.000
T50.6 Antidotes and chelating agents, not elsewhere classified
0.003 0.996 0.000
T44.6 Alpha-Adrenoreceeptor antagonists, not elsewhere classified
0.003 0.996 0.000
F34.9 Persistent mood [affective] disorder, unspecified
0.003 0.996 0.000
F34.8 Other persistent mood [affective] disorders
0.003 0.996 0.000
T45.9 Primarily systemic and haematological agent, unspecified
0.003 0.996 0.000
T45.8 Other primarily systemic and haematological agents
0.003 0.996 0.000
T45.7 Anticoagulant antagonists, vitamin K and other coagulants
0.003 0.996 0.000
T45.6 Fibrinolysis-affecting drugs
0.003 0.996 0.000
T45.3 Enzymes, not elsewhere classified
0.003 0.996 0.000
M00.90 Pyogenic arthritis, unspecified (Multiple sites)
0.003 0.996 0.000
S82.4 Fracture of fibula alone
0.003 0.996 0.000
E10.9 Without complications
0.004 0.996 0.000
J67.9 Hypersensitivity pneumonitis due to unspecified organic dust
0.000 0.996 0.003
J61 Pneumoconiosis due to asbestos and other mineral fibres
0.000 0.996 0.004
T37.9 Systemic anti-infective and antiparasitic, unspecified
0.003 0.996 0.000
T37.5 Antiviral drugs
0.003 0.996 0.000
T37.4 Anthelminthics
0.003 0.996 0.000
T37.3 Other antiprotozoal drugs
0.003 0.996 0.000
T37.1 Antimycobacterial drugs
0.003 0.996 0.000
T37.0 Sulphonamides
0.003 0.996 0.000
M00 Pyogenic arthritis
0.003 0.996 0.000
M00.94 Pyogenic arthritis, unspecified (Hand)
0.003 0.996 0.000
T43.9 Psychotropic drug, unspecified
0.003 0.996 0.000
S86.0 Injury of Achilles tendon
0.003 0.997 0.000
S86.7 Injury of multiple muscles and tendons at lower leg level
0.003 0.997 0.000
S86.2 Injury of muscle(s) and tendon(s) of anterior muscle group at lower leg level
0.003 0.997 0.000
T43.6 Psychostimulants with abuse potential
0.003 0.997 0.000
T45.4 Iron and its compounds
0.003 0.997 0.000
F30.1 Mania without psychotic symptoms
0.003 0.997 0.000
F33.1 Recurrent depressive disorder, current episode moderate
0.003 0.997 0.000
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system
0.003 0.997 0.000
T41.5 Therapeutic gases
0.003 0.997 0.000
T41.4 Anaesthetic, unspecified
0.003 0.997 0.000
T41.3 Local anaesthetics
0.003 0.997 0.000
T41.1 Intravenous anaesthetics
0.003 0.997 0.000
T41.0 Inhaled anaesthetics
0.003 0.997 0.000
F31.5 Bipolar affective disorder, current episode severe depression with psychotic symptoms
0.003 0.997 0.000
S82.6 Fracture of lateral malleolus
0.003 0.997 0.000
M00.93 Pyogenic arthritis, unspecified (Forearm)
0.003 0.997 0.000
E14.5 With peripheral circulatory complications
0.003 0.997 0.000
S82.9 Fracture of lower leg, part unspecified
0.003 0.997 0.000
F33.2 Recurrent depressive disorder, current episode severe without psychotic symptoms
0.003 0.997 0.000
T47.4 Other laxatives
0.003 0.997 0.000
T47.6 Antidiarrhoeal drugs
0.003 0.997 0.000
F31.1 Bipolar affective disorder, current episode manic without psychotic symptoms
0.003 0.997 0.000
T45.5 Anticoagulants
0.003 0.997 0.000
F33.0 Recurrent depressive disorder, current episode mild
0.003 0.997 0.000
S86.3 Injury of muscle(s) and tendon(s) of peroneal muscle group at lower leg level
0.003 0.997 0.000
T47.9 Agent primarily affecting the gastro-intestinal system, unspecified
0.003 0.997 0.000
T47.8 Other agents primarily affecting the gastro-intestinal system
0.003 0.997 0.000
T47.7 Emetics
0.003 0.997 0.000
T47.5 Digestants
0.003 0.997 0.000
T47.3 Saline and osmotic laxatives
0.003 0.997 0.000
M00.8 Arthritis and polyarthritis due to other specified bacterial agents
0.003 0.997 0.000
S80.1 Contusion of other and unspecified parts of lower leg
0.003 0.997 0.000
T36.0 Penicillins
0.003 0.997 0.000
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.003 0.997 0.000
F30.8 Other manic episodes
0.003 0.997 0.000
F38.0 Other single mood [affective] disorders
0.003 0.997 0.000
T47.2 Stimulant laxatives
0.003 0.997 0.000
E14.8 With unspecified complications
0.003 0.997 0.000
S80.7 Multiple superficial injuries of lower leg
0.003 0.997 0.000
T47.1 Other antacids and anti-gastric-secretion drugs
0.003 0.997 0.000
F33.4 Recurrent depressive disorder, currently in remission
0.003 0.997 0.000
T47.0 Histamine H(2)-receptor antagonists
0.003 0.997 0.000
W50.9 Unspecified place
0.000 0.997 0.003
F30.9 Manic episode, unspecified
0.003 0.997 0.000
F30.2 Mania with psychotic symptoms
0.003 0.997 0.000
F38.1 Other recurrent mood [affective] disorders
0.003 0.997 0.000
S80.0 Contusion of knee
0.003 0.997 0.000
S82.8 Fractures of other parts of lower leg
0.003 0.997 0.000
F31.2 Bipolar affective disorder, current episode manic with psychotic symptoms
0.003 0.997 0.000
M46.8 Other specified inflammatory spondylopathies
0.003 0.997 0.000
M46.5 Other infective spondylopathies
0.003 0.997 0.000
M46.4 Discitis, unspecified
0.003 0.997 0.000
S82.2 Fracture of shaft of tibia
0.003 0.997 0.000
M00.0 Staphylococcal arthritis and polyarthritis
0.003 0.997 0.000
T49.9 Topical agent, unspecified
0.003 0.997 0.000
T49.8 Other topical agents
0.003 0.997 0.000
T49.7 Dental drugs, topically applied
0.003 0.997 0.000
T49.6 Otorhinolaryngological drugs and preparations
0.003 0.997 0.000
T49.5 Ophthalmological drugs and preparations
0.003 0.997 0.000
T49.4 Keratolytics, keratoplastics and other hair treatment drugs and preparations
0.003 0.997 0.000
T49.3 Emollients, demulcents and protectants
0.003 0.997 0.000
T49.2 Local astringents and local detergents
0.003 0.997 0.000
T49.1 Antipruritics
0.003 0.997 0.000
F38.8 Other specified mood [affective] disorders
0.003 0.997 0.000
M00.86 Arthritis and polyarthritis due to other specified bacterial agents (Lower leg)
0.003 0.997 0.000
H26.4 After-cataract
0.000 0.997 0.003
S82.3 Fracture of lower end of tibia
0.002 0.997 0.001
S82.71 Multiple fractures of lower leg (open)
0.003 0.997 0.000
M46.44 Discitis, unspecified (Thoracic region)
0.003 0.997 0.000
M46.3 Infection of intervertebral disk (pyogenic)
0.003 0.997 0.000
S82.5 Fracture of medial malleolus
0.003 0.997 0.000
T42.7 Antiepileptic and sedative-hypnotic drugs, unspecified
0.003 0.997 0.000
S80.9 Superficial injury of lower leg, unspecified
0.003 0.997 0.000
S82.41 Fracture of fibula alone (open)
0.003 0.997 0.000
B95.4 Other streptococcus as the cause of diseases classified to other chapters
0.003 0.997 0.000
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs
0.003 0.997 0.000
S82.81 Fractures of other parts of lower leg (open)
0.003 0.997 0.000
G50.0 Trigeminal neuralgia
0.000 0.997 0.003
M00.2 Other streptococcal arthritis and polyarthritis
0.003 0.997 0.000
M00.1 Pneumococcal arthritis and polyarthritis
0.003 0.997 0.000
J67 Hypersensitivity pneumonitis due to organic dust
0.000 0.997 0.003
S82.30 Fracture of lower end of tibia (closed)
0.000 0.997 0.003
S86.00 Unspecified injury of Achilles tendon
0.002 0.997 0.000
F30.0 Hypomania
0.003 0.997 0.000
S86.1 Injury of other muscle(s) and tendon(s) of posterior muscle group at lower leg level
0.002 0.997 0.000
N88.9 Noninflammatory disorder of cervix uteri, unspecified
0.000 0.997 0.003
T48.7 Other and unspecified agents primarily acting on the respiratory system
0.002 0.997 0.000
T48.4 Expectorants
0.002 0.997 0.000
T48.3 Antitussives
0.002 0.997 0.000
T48.2 Other and unspecified agents primarily acting on muscles
0.002 0.997 0.000
T48.1 Skeletal muscle relaxants [neuromuscular blocking agents]
0.002 0.997 0.000
T48.0 Oxytocic drugs
0.002 0.997 0.000
M46.0 Spinal enthesopathy
0.003 0.997 0.000
T49.0 Local antifungal, anti-infective and anti-inflammatory drugs, not elsewhere classified
0.002 0.997 0.000
M46.1 Sacro-iliitis, not elsewhere classified
0.003 0.997 0.000
F33.8 Other recurrent depressive disorders
0.003 0.997 0.000
S82.70 Multiple fractures of lower leg (closed)
0.002 0.997 0.000
M46.2 Osteomyelitis of vertebra
0.002 0.997 0.000
T38.1 Thyroid hormones and substitutes
0.003 0.997 0.000
N47 Redundant prepuce, phimosis and paraphimosis
0.003 0.997 0.000
S86.8 Injury of other muscles and tendons at lower leg level
0.002 0.997 0.000
S82.61 Fracture of lateral malleolus (open)
0.002 0.997 0.000
M00.06 Staphylococcal arthritis and polyarthritis (Lower leg)
0.002 0.997 0.000
S82.21 Fracture of shaft of tibia (open)
0.003 0.997 0.000
G95.8 Other specified diseases of spinal cord
0.003 0.997 0.000
T48.5 Anti-common-cold drugs
0.002 0.997 0.000
M46.47 Discitis, unspecified (Lumbosacral region)
0.002 0.997 0.000
E16 Other disorders of pancreatic internal secretion
0.003 0.997 0.000
T38.5 Other oestrogens and progestogens
0.002 0.997 0.000
M00.89 Arthritis and polyarthritis due to other specified bacterial agents (Site unspecified)
0.002 0.997 0.000
M00.88 Arthritis and polyarthritis due to other specified bacterial agents (Other)
0.002 0.997 0.000
M00.87 Arthritis and polyarthritis due to other specified bacterial agents (Ankle and foot)
0.002 0.997 0.000
M00.85 Arthritis and polyarthritis due to other specified bacterial agents (Pelvic region and thigh)
0.002 0.997 0.000
M00.84 Arthritis and polyarthritis due to other specified bacterial agents (Hand)
0.002 0.997 0.000
M00.83 Arthritis and polyarthritis due to other specified bacterial agents (Forearm)
0.002 0.997 0.000
M00.82 Arthritis and polyarthritis due to other specified bacterial agents (Upper arm)
0.002 0.997 0.000
M00.81 Arthritis and polyarthritis due to other specified bacterial agents (Shoulder region)
0.002 0.997 0.000
M00.80 Arthritis and polyarthritis due to other specified bacterial agents (Multiple sites)
0.002 0.997 0.000
E14.9 Without complications
0.003 0.997 0.000
T38.9 Other and unspecified hormone antagonists
0.002 0.997 0.000
T38.7 Androgens and anabolic congeners
0.002 0.997 0.000
T38.4 Oral contraceptives
0.002 0.997 0.000
T38.2 Antithyroid drugs
0.002 0.997 0.000
M43.17 Spondylolisthesis (Lumbosacral region)
0.003 0.997 0.000
S82.91 Fracture of lower leg, part unspecified (open)
0.002 0.997 0.000
M46.34 Infection of intervertebral disc (pyogenic) (Thoracic region)
0.002 0.998 0.000
S82.86 Maisonneuve's fracture
0.002 0.998 0.000
M46.59 Other infective spondylopathies (Site unspecified)
0.002 0.998 0.000
M46.58 Other infective spondylopathies (Sacral and sacrococcygeal region)
0.002 0.998 0.000
M46.57 Other infective spondylopathies (Lumbosacral region)
0.002 0.998 0.000
M46.56 Other infective spondylopathies (Lumbar region)
0.002 0.998 0.000
M46.55 Other infective spondylopathies (Thoracolumbar region)
0.002 0.998 0.000
M46.54 Other infective spondylopathies (Thoracic region)
0.002 0.998 0.000
M46.53 Other infective spondylopathies (Cervicothoracic region)
0.002 0.998 0.000
M46.52 Other infective spondylopathies (Cervical region)
0.002 0.998 0.000
M46.51 Other infective spondylopathies (Occipito-atlanto-axial region)
0.002 0.998 0.000
M46.50 Other infective spondylopathies (Multiple sites in spine)
0.002 0.998 0.000
M46.89 Other specified inflammatory spondylopathies (Site unspecified)
0.002 0.998 0.000
M46.88 Other specified inflammatory spondylopathies (Sacral and sacrococcygeal region)
0.002 0.998 0.000
M46.87 Other specified inflammatory spondylopathies (Lumbosacral region)
0.002 0.998 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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