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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2223464
log Bayes Factor = 15.4752
Chromosome 6   position 27,356,216  (GRCh37) Explore rs2223464 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E83.1 Disorders of iron metabolism
0.000 0.000 1.000
K90.0 Coeliac disease
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.443 0.557
E10.9 Without complications
0.000 0.445 0.555
E10.4 With neurological complications
0.000 0.483 0.517
E10.5 With peripheral circulatory complications
0.000 0.490 0.510
E10.6 With other specified complications
0.000 0.499 0.501
E10.8 With unspecified complications
0.000 0.532 0.468
E10-E14 Diabetes mellitus
0.000 0.570 0.430
E10.2 With renal complications
0.000 0.587 0.413
E10.1 With ketoacidosis
0.000 0.590 0.410
E10.7 With multiple complications
0.000 0.601 0.399
E10.0 With coma
0.000 0.624 0.376
E13 Other specified diabetes mellitus
0.000 0.634 0.366
E10.3 With ophthalmic complications
0.000 0.641 0.359
E14 Unspecified diabetes mellitus
0.000 0.657 0.343
E83 Disorders of mineral metabolism
0.000 0.658 0.342
E14.3 With ophthalmic complications
0.000 0.669 0.331
E13.9 Without complications
0.000 0.677 0.323
K90 Intestinal malabsorption
0.000 0.687 0.312
E12 Malnutrition-related diabetes mellitus
0.000 0.692 0.308
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.694 0.306
E70-E90 Metabolic disorders
0.000 0.698 0.302
E13.8 With unspecified complications
0.000 0.738 0.262
E13.7 With multiple complications
0.000 0.738 0.262
E13.6 With other specified complications
0.000 0.738 0.262
E13.5 With peripheral circulatory complications
0.000 0.738 0.262
E13.4 With neurological complications
0.000 0.738 0.262
E13.2 With renal complications
0.000 0.738 0.262
E13.1 With ketoacidosis
0.000 0.738 0.262
E13.0 With coma
0.000 0.738 0.262
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.740 0.260
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.744 0.256
E13.3 With ophthalmic complications
0.000 0.744 0.256
E14.5 With peripheral circulatory complications
0.000 0.744 0.255
E40-E46 Malnutrition
0.000 0.745 0.255
E88 Other metabolic disorders
0.000 0.749 0.251
E14.7 With multiple complications
0.000 0.754 0.246
E14.6 With other specified complications
0.000 0.754 0.246
E14.2 Withrenal complications
0.000 0.754 0.246
E14.0 With coma
0.000 0.754 0.246
E83.9 Disorder of mineral metabolism, unspecified
0.000 0.755 0.245
E83.8 Other disorders of mineral metabolism
0.000 0.755 0.245
E83.2 Disorders of zinc metabolism
0.000 0.755 0.245
E83.0 Disorders of copper metabolism
0.000 0.755 0.245
E85 Amyloidosis
0.000 0.757 0.243
E14.4 With neurological complications
0.000 0.763 0.237
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.771 0.229
E16 Other disorders of pancreatic internal secretion
0.000 0.773 0.227
K90.3 Pancreatic steatorrhoea
0.000 0.776 0.224
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.776 0.224
K90.1 Tropical sprue
0.000 0.776 0.224
E12.9 Without complications
0.000 0.779 0.221
E12.8 With unspecified complications
0.000 0.779 0.221
E12.7 With multiple complications
0.000 0.779 0.221
E12.6 With other specified complications
0.000 0.779 0.221
E12.5 With peripheral circulatory complications
0.000 0.779 0.221
E12.4 With neurological complications
0.000 0.779 0.221
E12.3 With ophthalmic complications
0.000 0.779 0.221
E12.2 With renal complications
0.000 0.779 0.221
E12.1 With ketoacidosis
0.000 0.779 0.221
E12.0 With coma
0.000 0.779 0.221
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.779 0.221
E46 Unspecified protein-energy malnutrition
0.000 0.782 0.218
E84 Cystic fibrosis
0.000 0.784 0.216
E77 Disorders of glycoprotein metabolism
0.000 0.784 0.216
E76 Disorders of glycosaminoglycan metabolism
0.000 0.784 0.216
E72 Other disorders of amino-acid metabolism
0.000 0.784 0.216
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.784 0.216
E70 Disorders of aromatic amino-acid metabolism
0.000 0.784 0.216
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.784 0.216
K90.8 Other intestinal malabsorption
0.000 0.785 0.215
E16.2 Hypoglycaemia, unspecified
0.000 0.788 0.212
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.790 0.210
E65-E68 Obesity and other hyperalimentation
0.000 0.791 0.209
E14.1 With ketoacidosis
0.000 0.792 0.208
E14.8 With unspecified complications
0.000 0.797 0.203
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.797 0.203
E85.9 Amyloidosis, unspecified
0.000 0.798 0.202
E11 Non-insulin-dependent diabetes mellitus
0.000 0.804 0.196
E79 Disorders of purine and pyrimidine metabolism
0.000 0.804 0.196
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.808 0.192
E88.8 Other specified metabolic disorders
0.000 0.809 0.191
E88.2 Lipomatosis, not elsewhere classified
0.000 0.811 0.189
E15 Nondiabetic hypoglycaemic coma
0.000 0.813 0.186
E89.2 Postprocedural hypoparathyroidism
0.000 0.817 0.183
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.817 0.183
E45 Retarded development following protein-energy malnutrition
0.000 0.817 0.183
E43 Unspecified severe protein-energy malnutrition
0.000 0.817 0.183
E42 Marasmic kwashiorkor
0.000 0.817 0.183
E41 Nutritional marasmus
0.000 0.817 0.183
E40 Kwashiorkor
0.000 0.817 0.183
E85.4 Organ-limited amyloidosis
0.000 0.817 0.182
E88.3 Tumour lysis syndrome
0.000 0.819 0.181
E89.0 Postprocedural hypothyroidism
0.000 0.821 0.179
E65 Localised adiposity
0.000 0.822 0.178
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.823 0.177
E85.8 Other amyloidosis
0.000 0.826 0.174
E85.2 Heredofamilial amyloidosis, unspecified
0.000 0.826 0.174
E85.1 Neuropathic heredofamilial amyloidosis
0.000 0.826 0.174
E85.0 Nonneuropathic heredofamilial amyloidosis
0.000 0.826 0.174
E89.4 Postprocedural ovarian failure
0.000 0.829 0.171
E74 Other disorders of carbohydrate metabolism
0.000 0.830 0.170
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.832 0.168
E88.9 Metabolic disorder, unspecified
0.000 0.832 0.168
E11.5 With peripheral circulatory complications
0.000 0.833 0.167
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.836 0.164
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.836 0.164
E89.5 Postprocedural testicular hypofunction
0.000 0.836 0.164
E89.1 Postprocedural hypoinsulinaemia
0.000 0.836 0.164
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.837 0.163
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.837 0.163
E16.4 Abnormal secretion of gastrin
0.000 0.837 0.163
E16.3 Increased secretion of glucagon
0.000 0.837 0.163
E75.5 Other lipid storage disorders
0.000 0.837 0.163
E85.3 Secondary systemic amyloidosis
0.000 0.838 0.162
E73 Lactose intolerance
0.000 0.841 0.158
E75.6 Lipid storage disorder, unspecified
0.000 0.841 0.158
E75.4 Neuronal ceroid lipofuscinosis
0.000 0.841 0.158
E75.3 Sphingolipidosis, unspecified
0.000 0.841 0.158
E75.2 Other sphingolipidosis
0.000 0.841 0.158
E75.1 Other gangliosidosis
0.000 0.841 0.158
E75.0 GM2 gangliosidosis
0.000 0.841 0.158
E80.4 Gilbert's syndrome
0.000 0.843 0.157
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.845 0.155
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.845 0.155
E70.3 Albinism
0.000 0.845 0.155
E70.2 Disorders of tyrosine metabolism
0.000 0.845 0.155
E70.1 Other hyperphenylalaninaemias
0.000 0.845 0.155
E70.0 Classical phenylketonuria
0.000 0.845 0.155
E71.3 Disorders of fatty-acid metabolism
0.000 0.845 0.155
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.845 0.155
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.845 0.155
E71.0 Maple-syrup-urine disease
0.000 0.845 0.155
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.845 0.155
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.845 0.155
E72.5 Disorders of glycine metabolism
0.000 0.845 0.155
E72.4 Disorders of ornithine metabolism
0.000 0.845 0.155
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.845 0.155
E72.2 Disorders of urea cycle metabolism
0.000 0.845 0.155
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.000 0.845 0.155
E72.0 Disorders of amino-acid transport
0.000 0.845 0.155
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.845 0.155
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.845 0.155
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.845 0.155
E76.2 Other mucopolysaccharidoses
0.000 0.845 0.155
E76.1 Mucopolysaccharidosis, type II
0.000 0.845 0.155
E76.0 Mucopolysaccharidosis, type I
0.000 0.845 0.155
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.845 0.155
E77.8 Other disorders of glycoprotein metabolism
0.000 0.845 0.155
E77.1 Defects in glycoprotein degradation
0.000 0.845 0.155
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.845 0.155
E84.9 Cystic fibrosis, unspecified
0.000 0.845 0.155
E84.8 Cystic fibrosis with other manifestations
0.000 0.845 0.155
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.845 0.155
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.845 0.155
E80.7 Disorder of bilirubin metabolism, unspecified
0.000 0.849 0.150
E80.5 Crigler-Najjar syndrome
0.000 0.849 0.150
E80.3 Defects of catalase and peroxydase
0.000 0.849 0.150
E80.1 Porphyria cutanea tarda
0.000 0.849 0.150
E80.0 Hereditary erythropoietic porphyria
0.000 0.849 0.150
E67 Other hyperalimentation
0.000 0.850 0.150
E68 Sequelae of hyperalimentation
0.000 0.850 0.150
E11.0 With coma
0.000 0.850 0.150
E11.8 With unspecified complications
0.000 0.853 0.146
E80.2 Other porphyria
0.000 0.855 0.145
E83.3 Disorders of phosphorus metabolism
0.000 0.856 0.144
E11.1 With ketoacidosis
0.000 0.857 0.143
E80.6 Other disorders of bilirubin metabolism
0.000 0.857 0.143
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.859 0.141
E11.7 With multiple complications
0.000 0.859 0.141
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.859 0.140
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.859 0.140
E79.1 Lesch-Nyhan syndrome
0.000 0.859 0.140
E11.2 With renal complications
0.000 0.859 0.140
E83.4 Disorders of magnesium metabolism
0.000 0.860 0.140
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.864 0.136
E11.6 With other specified complications
0.000 0.866 0.134
E44.1 Mild protein-energy malnutrition
0.000 0.869 0.131
E44.0 Moderate protein-energy malnutrition
0.000 0.869 0.131
E00-E07 Disorders of thyroid gland
0.000 0.872 0.128
E11.4 With neurological complications
0.000 0.873 0.127
E16.1 Other hypoglycaemia
0.000 0.877 0.123
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.878 0.122
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.878 0.122
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.878 0.122
E74.2 Disorders of galactose metabolism
0.000 0.878 0.122
E74.1 Disorders of fructose metabolism
0.000 0.878 0.122
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.880 0.120
E78.4 Other hyperlipidaemia
0.000 0.881 0.119
E87 Other disorders of fluid, electrolyte and acid-base balance
0.000 0.882 0.118
E73.8 Other lactose intolerance
0.000 0.886 0.114
E73.1 Secondary lactase deficiency
0.000 0.886 0.114
E73.0 Congenital lactase deficiency
0.000 0.886 0.114
E74.0 Glycogen storage disease
0.000 0.888 0.112
E67.8 Other specified hyperalimentation
0.000 0.892 0.108
E67.3 Hypervitaminosis D
0.000 0.892 0.108
E67.2 Megavitamin-B6 syndrome
0.000 0.892 0.108
E67.1 Hypercarotenaemia
0.000 0.892 0.108
E67.0 Hypervitaminosis A
0.000 0.892 0.108
E87.3 Alkalosis
0.000 0.893 0.107
E78.6 Lipoprotein deficiency
0.000 0.893 0.107
E14.9 Without complications
0.000 0.894 0.106
E11.3 With ophthalmic complications
0.000 0.894 0.106
E50-E64 Other nutritional deficiencies
0.000 0.896 0.104
E07 Other disorders of thyroid
0.000 0.897 0.103
E78.3 Hyperchylomicronaemia
0.000 0.898 0.101
K90.9 Intestinal malabsorption, unspecified
0.000 0.899 0.101
E89.3 Postprocedural hypopituitarism
0.000 0.901 0.098
E87.0 Hyperosmolality and hypernatraemia
0.000 0.903 0.097
E78.1 Pure hyperglyceridaemia
0.000 0.904 0.095
E87.2 Acidosis
0.000 0.905 0.095
E78.2 Mixed hyperlipidaemia
0.000 0.906 0.094
E74.3 Other disorders of intestinal carbohydrate absorption
0.000 0.907 0.092
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.908 0.092
E00 Congenital iodine-deficiency syndrome
0.000 0.908 0.092
E04 Other non-toxic goitre
0.000 0.909 0.091
E20-E35 Disorders of other endocrine glands
0.000 0.911 0.089
E07.9 Disorder of thyroid, unspecified
0.000 0.911 0.089
E06 Thyroiditis
0.000 0.914 0.086
E87.4 Mixed disorder of acid-base balance
0.000 0.915 0.085
E87.7 Fluid overload
0.000 0.917 0.083
E03 Other hypothyroidism
0.000 0.917 0.083
E66 Obesity
0.000 0.922 0.078
E04.9 Non-toxic goitre, unspecified
0.000 0.922 0.078
E83.5 Disorders of calcium metabolism
0.000 0.924 0.076
E87.5 Hyperkalaemia
0.000 0.924 0.076
E03.8 Other specified hypothyroidism
0.000 0.925 0.075
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.925 0.074
E63 Other nutritional deficiencies
0.000 0.925 0.074
E56 Other vitamin deficiencies
0.000 0.925 0.074
E50 Vitamin A deficiency
0.000 0.925 0.074
E60 Dietary zinc deficiency
0.000 0.925 0.074
E59 Dietary selenium deficiency
0.000 0.925 0.074
E54 Ascorbic acid deficiency
0.000 0.925 0.074
E52 Niacin deficiency [pellagra]
0.000 0.925 0.074
E07.1 Dyshormogenetic goitre
0.000 0.926 0.074
E07.0 Hypersecretion of calcitonin
0.000 0.926 0.074
E58 Dietary calcium deficiency
0.000 0.926 0.074
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.930 0.070
E53 Deficiency of other B group vitamins
0.000 0.930 0.069
E51 Thiamine deficiency
0.000 0.931 0.069
E04.0 Non-toxic diffuse goitre
0.000 0.932 0.068
E28 Ovarian dysfunction
0.000 0.932 0.068
E20 Hypoparathyroidism
0.000 0.932 0.068
E26 Hyperaldosteronism
0.000 0.933 0.067
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.934 0.066
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.934 0.066
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.934 0.066
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.934 0.066
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.934 0.066
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.934 0.066
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.934 0.066
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.934 0.066
E07.8 Other specified disorders of thyroid
0.000 0.935 0.065
E04.8 Other specified non-toxic goitre
0.000 0.935 0.065
E66.2 Extreme obesity with alveolar hypoventilation
0.000 0.935 0.065
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.936 0.064
E32 Diseases of thymus
0.000 0.936 0.064
E31 Polyglandular dysfunction
0.000 0.936 0.064
E30 Disorders of puberty, not elsewhere classified
0.000 0.936 0.064
E25 Adrenogenital disorders
0.000 0.936 0.064
E29 Testicular dysfunction
0.000 0.936 0.064
E06.3 Autoimmune thyroiditis
0.000 0.937 0.063
E23 Hypofunction and other disorders of pituitary gland
0.000 0.937 0.063
E06.5 Other chronic thyroiditis
0.000 0.938 0.062
E06.4 Drug-induced thyroiditis
0.000 0.938 0.062
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.938 0.062
E06.1 Subacute thyroiditis
0.000 0.938 0.062
E06.0 Acute thyroiditis
0.000 0.938 0.062
E34 Other endocrine disorders
0.000 0.939 0.061
E28.2 Polycystic ovarian syndrome
0.000 0.940 0.060
E03.5 Myxoedema coma
0.000 0.940 0.060
E03.4 Atrophy of thyroid (acquired)
0.000 0.940 0.060
E03.3 Postinfectious hypothyroidism
0.000 0.940 0.060
E03.1 Congenital hypothyroidism without goitre
0.000 0.940 0.060
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.940 0.060
E78.8 Other disorders of lipoprotein metabolism
0.000 0.940 0.060
E87.8 Other disorders of electrolyte and fluid balance, not elsewhere classified
0.000 0.940 0.060
E24 Cushing's syndrome
0.000 0.941 0.059
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.941 0.059
E55 Vitamin D deficiency
0.000 0.942 0.058
E23.2 Diabetes insipidus
0.000 0.942 0.058
E73.9 Lactose intolerance, unspecified
0.001 0.944 0.055
E66.1 Drug-induced obesity
0.000 0.944 0.056
E04.2 Non-toxic multinodular goitre
0.000 0.944 0.056
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.944 0.056
E06.9 Thyroiditis, unspecified
0.000 0.946 0.054
E50.9 Vitamin A deficiency, unspecified
0.000 0.946 0.053
E50.8 Other manifestations of vitamin A deficiency
0.000 0.946 0.053
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.946 0.053
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.946 0.053
E50.5 Vitamin A deficiency with night blindness
0.000 0.946 0.053
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.946 0.053
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.946 0.053
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.946 0.053
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.946 0.053
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.946 0.053
E56.9 Vitamin deficiency, unspecified
0.000 0.946 0.053
E56.8 Deficiency of other vitamins
0.000 0.946 0.053
E56.1 Deficiency of vitamin K
0.000 0.946 0.053
E56.0 Deficiency of vitamin E
0.000 0.946 0.053
E63.9 Nutritional deficiency, unspecified
0.000 0.946 0.053
E63.8 Other specified nutritional deficiencies
0.000 0.946 0.053
E63.1 Imbalance of constituents of food intake
0.000 0.946 0.053
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.946 0.053
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.946 0.053
E64.8 Sequelae of other nutritional deficiencies
0.000 0.946 0.053
E64.3 Sequelae of rickets
0.000 0.946 0.053
E64.2 Sequelae of vitamin C deficiency
0.000 0.946 0.053
E64.1 Sequelae of vitamin A deficiency
0.000 0.946 0.053
E64.0 Sequelae of protein-energy malnutrition
0.000 0.946 0.053
E66.0 Obesity due to excess calories
0.000 0.946 0.054
E27 Other disorders of adrenal gland
0.000 0.947 0.053
E20.9 Hypoparathyroidism, unspecified
0.000 0.948 0.052
E26.0 Primary hyperaldosteronism
0.000 0.949 0.051
E53.1 Pyridoxine deficiency
0.000 0.950 0.050
E53.0 Riboflavin deficiency
0.000 0.950 0.050
E51.9 Thiamine deficiency, unspecified
0.000 0.950 0.049
E51.8 Other manifestations of thiamine deficiency
0.000 0.950 0.049
E51.1 Beriberi
0.000 0.950 0.049
E53.9 Vitamin B deficiency, unspecified
0.000 0.950 0.049
E27.1 Primary adrenocortical insufficiency
0.000 0.950 0.050
E24.2 Drug-induced Cushing's syndrome
0.000 0.951 0.049
E28.9 Ovarian dysfunction, unspecified
0.000 0.951 0.049
E28.8 Other ovarian dysfunction
0.000 0.951 0.049
E28.1 Androgen excess
0.000 0.951 0.049
E28.0 Oestrogen excess
0.000 0.951 0.049
E20.8 Other hypoparathyroidism
0.000 0.951 0.049
E20.1 Pseudohypoparathyroidism
0.000 0.951 0.049
E20.0 Idiopathic hypoparathyroidism
0.000 0.951 0.049
E26.9 Hyperaldosteronism, unspecified
0.000 0.952 0.048
E26.8 Other hyperaldosteronism
0.000 0.952 0.048
E26.1 Secondary hyperaldosteronism
0.000 0.952 0.048
E25.9 Adrenogenital disorder, unspecified
0.000 0.954 0.046
E25.8 Other adrenogenital disorders
0.000 0.954 0.046
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.954 0.046
E30.9 Disorder of puberty, unspecified
0.000 0.954 0.046
E30.8 Other disorders of puberty
0.000 0.954 0.046
E30.1 Precocious puberty
0.000 0.954 0.046
E30.0 Delayed puberty
0.000 0.954 0.046
E31.9 Polyglandular dysfunction, unspecified
0.000 0.954 0.046
E31.8 Other polyglandular dysfunction
0.000 0.954 0.046
E31.1 Polyglandular hyperfunction
0.000 0.954 0.046
E31.0 Autoimmune polyglandular failure
0.000 0.954 0.046
E32.9 Disease of thymus, unspecified
0.000 0.954 0.046
E32.8 Other diseases of thymus
0.000 0.954 0.046
E32.1 Abscess of thymus
0.000 0.954 0.046
E32.0 Persistent hyperplasia of thymus
0.000 0.954 0.046
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.954 0.046
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.954 0.046
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.954 0.046
E29.9 Testicular dysfunction, unspecified
0.000 0.954 0.046
E29.8 Other testicular dysfunction
0.000 0.954 0.046
E29.0 Testicular hyperfunction
0.000 0.954 0.046
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.954 0.045
E23.1 Drug-induced hypopituitarism
0.000 0.954 0.045
E53.8 Deficiency of other specified B group vitamins
0.000 0.955 0.045
E29.1 Testicular hypofunction
0.000 0.955 0.045
E04.1 Non-toxic single thyroid nodule
0.000 0.955 0.045
E23.7 Disorder of pituitary gland, unspecified
0.000 0.956 0.044
E34.5 Androgen resistance syndrome
0.000 0.956 0.044
E34.4 Constitutional tall stature
0.000 0.956 0.044
E34.3 Short stature, not elsewhere classified
0.000 0.956 0.044
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.956 0.044
E34.1 Other hypersecretion of intestinal hormones
0.000 0.956 0.044
E51.2 Wernicke's encephalopathy
0.000 0.956 0.043
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.957 0.043
E34.9 Endocrine disorder, unspecified
0.000 0.957 0.043
E24.8 Other Cushing's syndrome
0.000 0.957 0.043
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.957 0.043
E24.3 Ectopic ACTH syndrome
0.000 0.957 0.043
E24.1 Nelson's syndrome
0.000 0.957 0.043
E34.0 Carcinoid syndrome
0.000 0.958 0.042
E34.8 Other specified endocrine disorders
0.000 0.958 0.042
E55.0 Rickets, active
0.000 0.958 0.042
E05.8 Other thyrotoxicosis
0.000 0.958 0.041
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.959 0.041
E05.5 Thyroid crisis or storm
0.000 0.960 0.040
E05.4 Thyrotoxicosis factitia
0.000 0.960 0.040
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.960 0.040
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.960 0.040
E23.6 Other disorders of pituitary gland
0.000 0.960 0.040
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.960 0.040
E61 Deficiency of other nutrient elements
0.001 0.960 0.039
E27.5 Adrenomedullary hyperfunction
0.000 0.961 0.038
E27.0 Other adrenocortical overactivity
0.000 0.961 0.038
E24.0 Pituitary-dependent Cushing's disease
0.000 0.962 0.038
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.963 0.037
E24.9 Cushing's syndrome, unspecified
0.000 0.968 0.031
E28.3 Primary ovarian failure
0.000 0.969 0.031
E21.3 Hyperparathyroidism, unspecified
0.000 0.970 0.030
E66.9 Obesity, unspecified
0.000 0.970 0.030
E21.4 Other specified disorders of parathyroid gland
0.000 0.970 0.030
E21.2 Other hyperparathyroidism
0.000 0.970 0.030
E27.2 Addisonian crisis
0.000 0.970 0.030
E22 Hyperfunction of pituitary gland
0.000 0.971 0.029
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.971 0.029
E61.9 Deficiency of nutrient element, unspecified
0.001 0.971 0.028
E61.8 Deficiency of other specified nutrient elements
0.001 0.971 0.028
E61.7 Deficiency of multiple nutrient elements
0.001 0.971 0.028
E61.6 Vanadium deficiency
0.001 0.971 0.028
E61.5 Molybdenum deficiency
0.001 0.971 0.028
E61.4 Chromium deficiency
0.001 0.971 0.028
E61.3 Manganese deficiency
0.001 0.971 0.028
E61.0 Copper deficiency
0.001 0.971 0.028
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.973 0.027
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.973 0.027
E86 Volume depletion
0.000 0.973 0.027
E55.9 Vitamin D deficiency, unspecified
0.000 0.974 0.026
E27.8 Other specified disorders of adrenal gland
0.000 0.975 0.025
E27.9 Disorder of adrenal gland, unspecified
0.000 0.975 0.024
E23.0 Hypopituitarism
0.000 0.977 0.023
E61.2 Magnesium deficiency
0.001 0.977 0.022
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.979 0.021
E22.8 Other hyperfunction of pituitary gland
0.000 0.979 0.021
K90-K93 Other diseases of the digestive system
0.000 0.980 0.020
R31 Unspecified haematuria
0.019 0.981 0.000
E22.1 Hyperprolactinaemia
0.000 0.981 0.019
E21.0 Primary hyperparathyroidism
0.000 0.983 0.017
K93 Disorders of other digestive organs in diseases classified elsewhere
0.000 0.986 0.014
E22.0 Acromegaly and pituitary gigantism
0.000 0.986 0.013
E87.6 Hypokalaemia
0.000 0.987 0.013
E05.9 Thyrotoxicosis, unspecified
0.000 0.987 0.013
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.988 0.011
E66.8 Other obesity
0.000 0.989 0.011
K93.8 Disorders of other specified digestive organs in diseases classified elsewhere
0.000 0.989 0.010
K93.1 Megacolon in Chagas' disease
0.000 0.989 0.010
K93.0 Tuberculous disorders of intestines, peritoneum and mesenteric glands
0.000 0.989 0.010
E61.1 Iron deficiency
0.001 0.990 0.009
C71.2 Temporal lobe
0.009 0.991 0.000
C71 Malignant neoplasm of brain
0.009 0.991 0.000
C71.9 Brain, unspecified
0.009 0.991 0.000
G31.8 Other specified degenerative diseases of nervous system
0.000 0.992 0.008
C71.3 Parietal lobe
0.008 0.992 0.000
C71.1 Frontal lobe
0.007 0.993 0.000
G31 Other degenerative diseases of nervous system, not elsewhere classified
0.000 0.993 0.007
C71.7 Brain stem
0.007 0.993 0.000
C71.6 Cerebellum
0.007 0.993 0.000
C71.5 Cerebral ventricle
0.007 0.993 0.000
C71.0 Cerebrum, except lobes and ventricles
0.007 0.993 0.000
C71.8 Overlapping lesion of brain
0.006 0.993 0.000
G31.0 Circumscribed brain atrophy
0.000 0.993 0.007
G31.9 Degenerative disease of nervous system, unspecified
0.000 0.994 0.006
G44.2 Tension-type headache
0.006 0.994 0.000
C71.4 Occipital lobe
0.005 0.994 0.000
E11.9 Without complications
0.000 0.995 0.005
N04.9 Unspecified
0.000 0.995 0.005
G54.9 Nerve root and plexus disorder, unspecified
0.005 0.995 0.000
G31.1 Senile degeneration of brain, not elsewhere classified
0.000 0.995 0.005
R52.1 Chronic intractable pain
0.005 0.995 0.000
C69-C72 Malignant neoplasms of eye, brain and other parts of central nervous system
0.005 0.995 0.000
M41.9 Scoliosis, unspecified
0.005 0.995 0.000
M41.96 Scoliosis, unspecified (Lumbar region)
0.005 0.995 0.000
M41.97 Scoliosis, unspecified (Lumbosacral region)
0.005 0.995 0.000
M41.94 Scoliosis, unspecified (Thoracic region)
0.005 0.995 0.000
G31.2 Degeneration of nervous system due to alcohol
0.000 0.995 0.005
M41.99 Scoliosis, unspecified (Site unspecified)
0.005 0.995 0.000
E87.1 Hypo-osmolality and hyponatraemia
0.000 0.995 0.005
I24.0 Coronary thrombosis not resulting in myocardial infarction
0.005 0.995 0.000
C69 Malignant neoplasm of eye and adnexa
0.004 0.996 0.000
K62.5 Haemorrhage of anus and rectum
0.004 0.996 0.000
C70 Malignant neoplasm of meninges
0.004 0.996 0.000
M67.8 Other specified disorders of synovium and tendon
0.000 0.996 0.004
M41.98 Scoliosis, unspecified (Sacral and sacrococcygeal region)
0.004 0.996 0.000
M41.93 Scoliosis, unspecified (Cervicothoracic region)
0.004 0.996 0.000
M41.92 Scoliosis, unspecified (Cervical region)
0.004 0.996 0.000
M41.91 Scoliosis, unspecified (Occipito-atlanto-axial region)
0.004 0.996 0.000
C69.3 Choroid
0.004 0.996 0.000
G30-G32 Other degenerative diseases of the nervous system
0.000 0.996 0.004
C69.9 Eye, unspecified
0.004 0.996 0.000
C72 Malignant neoplasm of spinal cord, cranial nerves and other parts of central nervous system
0.004 0.996 0.000
M41.95 Scoliosis, unspecified (Thoracolumbar region)
0.004 0.996 0.000
C70.0 Cerebral meninges
0.003 0.996 0.000
G30 Alzheimer's disease
0.000 0.996 0.003
I31.9 Disease of pericardium, unspecified
0.000 0.997 0.003
C69.8 Overlapping lesion of eye and adnexa
0.003 0.997 0.000
C69.5 Lachrymal gland and duct
0.003 0.997 0.000
C69.4 Ciliary body
0.003 0.997 0.000
C69.2 Retina
0.003 0.997 0.000
C69.1 Cornea
0.003 0.997 0.000
C69.6 Orbit
0.003 0.997 0.000
C69.0 Conjunctiva
0.003 0.997 0.000
G30.0 Alzheimer's disease with early onset
0.000 0.997 0.003
G55.3 Nerve root and plexus compressions in other dorsopathies
0.003 0.997 0.000
C70.9 Meninges, unspecified
0.003 0.997 0.000
C70.1 Spinal meninges
0.003 0.997 0.000
M79.10 Myalgia (Multiple sites)
0.003 0.997 0.000
M41.90 Scoliosis, unspecified (Multiple sites in spine)
0.003 0.997 0.000
R82.9 Other and unspecified abnormal finding in urine
0.000 0.997 0.003
M22.2 Patellofemoral disorders
0.003 0.997 0.000
M96.8 Other postprocedural musculoskeletal disorders
0.000 0.997 0.003
C72.9 Central nervous system, unspecified
0.003 0.997 0.000
C72.8 Overlapping lesion of brain and other parts of central nervous system
0.003 0.997 0.000
C72.5 Other and unspecified cranial nerves
0.003 0.997 0.000
C72.4 Acoustic nerve
0.003 0.997 0.000
C72.3 Optic nerve
0.003 0.997 0.000
C72.2 Olfactory nerve
0.003 0.997 0.000
C72.1 Cauda equina
0.003 0.997 0.000
N36.3 Prolapsed urethral mucosa
0.003 0.997 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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