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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2233952
log Bayes Factor = 30.0165
Chromosome 6   position 31,105,891  (GRCh37) Explore rs2233952 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E83.1 Disorders of iron metabolism
1.000 0.000 0.000
K90.0 Coeliac disease
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
L40.9 Psoriasis, unspecified
0.000 0.000 1.000
E10.9 Without complications
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.000 1.000
G35 Multiple sclerosis
0.999 0.001 0.000
G35-G37 Demyelinating diseases of the central nervous system
0.989 0.011 0.000
Chapter VI Diseases of the nervous system
0.981 0.019 0.000
E10.1 With ketoacidosis
0.000 0.027 0.973
G00-G09 Inflammatory diseases of the central nervous system
0.967 0.033 0.000
G20-G26 Extrapyramidal and movement disorders
0.952 0.048 0.000
L40 Psoriasis
0.000 0.052 0.948
E10-E14 Diabetes mellitus
0.000 0.055 0.945
G90-G99 Other disorders of the nervous system
0.940 0.060 0.000
G20 Parkinson's disease
0.908 0.092 0.000
G03 Meningitis due to other and unspecified causes
0.907 0.093 0.000
E10.2 With renal complications
0.000 0.096 0.904
E10.4 With neurological complications
0.000 0.104 0.896
G30-G32 Other degenerative diseases of the nervous system
0.895 0.105 0.000
G91 Hydrocephalus
0.893 0.107 0.000
L40.5 Arthropathic psoriasis
0.000 0.111 0.889
E03.9 Hypothyroidism, unspecified
0.000 0.116 0.884
G03.9 Meningitis, unspecified
0.864 0.136 0.000
G31 Other degenerative diseases of nervous system, not elsewhere classified
0.851 0.149 0.000
G93 Other disorders of brain
0.838 0.162 0.000
E03 Other hypothyroidism
0.000 0.164 0.835
G24 Dystonia
0.833 0.167 0.000
G31.9 Degenerative disease of nervous system, unspecified
0.831 0.169 0.000
G91.1 Obstructive hydrocephalus
0.831 0.169 0.000
G06 Intracranial and intraspinal abscess and granuloma
0.826 0.174 0.000
E11 Non-insulin-dependent diabetes mellitus
0.000 0.188 0.812
Chapter IV Endocrine, nutritional and metabolic diseases
0.002 0.189 0.809
E00-E07 Disorders of thyroid gland
0.001 0.190 0.809
E10.5 With peripheral circulatory complications
0.000 0.196 0.804
G04 Encephalitis, myelitis and encephalomyelitis
0.794 0.206 0.000
L40.0 Psoriasis vulgaris
0.000 0.215 0.785
K90 Intestinal malabsorption
0.000 0.216 0.784
G00 Bacterial meningitis, not elsewhere classified
0.776 0.224 0.000
E14 Unspecified diabetes mellitus
0.000 0.225 0.775
G96 Other disorders of central nervous system
0.775 0.225 0.000
G08 Intracranial and intraspinal phlebitis and thrombophlebitis
0.773 0.227 0.000
G91.9 Hydrocephalus, unspecified
0.766 0.234 0.000
E11.9 Without complications
0.000 0.242 0.758
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.756 0.244 0.000
G97 Postprocedural disorders of nervous system, not elsewhere classified
0.750 0.250 0.000
G37 Other demyelinating diseases of central nervous system
0.742 0.258 0.000
G93.4 Encephalopathy, unspecified
0.742 0.258 0.000
G09 Sequelae of inflammatory diseases of central nervous system
0.733 0.267 0.000
G31.2 Degeneration of nervous system due to alcohol
0.725 0.275 0.000
E10.8 With unspecified complications
0.000 0.283 0.717
E10.7 With multiple complications
0.000 0.283 0.717
E10.6 With other specified complications
0.000 0.283 0.717
E10.0 With coma
0.000 0.283 0.717
G98 Other disorders of nervous system, not elsewhere classified
0.717 0.283 0.000
G05 Encephalitis, myelitis and encephalomyelitis in diseases classified elsewhere
0.714 0.286 0.000
G93.8 Other specified disorders of brain
0.711 0.289 0.000
G36 Other acute disseminated demyelination
0.709 0.291 0.000
G80-G83 Cerebral palsy and other paralytic syndromes
0.709 0.291 0.000
E13 Other specified diabetes mellitus
0.000 0.299 0.701
G06.1 Intraspinal abscess and granuloma
0.697 0.303 0.000
G02 Meningitis in other infectious and parasitic diseases classified elsewhere
0.693 0.306 0.000
G07 Intracranial and intraspinal abscess and granuloma in diseases classified elsewhere
0.693 0.306 0.000
K90.9 Intestinal malabsorption, unspecified
0.000 0.308 0.692
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.001 0.312 0.686
G23 Other degenerative diseases of basal ganglia
0.683 0.317 0.000
G21 Secondary Parkinsonism
0.683 0.317 0.000
G26 Extrapyramidal and movement disorders in diseases classified elsewhere
0.683 0.317 0.000
G22 Parkinsonism in diseases classified elsewhere
0.683 0.317 0.000
L40.8 Other psoriasis
0.000 0.318 0.682
L40.4 Guttate psoriasis
0.000 0.320 0.679
L40.3 Pustulosis palmaris et plantaris
0.000 0.320 0.679
L40.2 Acrodermatitis continua
0.000 0.320 0.679
L40.1 Generalised pustular psoriasis
0.000 0.320 0.679
E12 Malnutrition-related diabetes mellitus
0.000 0.322 0.678
E11.6 With other specified complications
0.000 0.324 0.676
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.324 0.676
G92 Toxic encephalopathy
0.674 0.326 0.000
E11.5 With peripheral circulatory complications
0.000 0.330 0.670
G91.0 Communicating hydrocephalus
0.664 0.335 0.000
G24.9 Dystonia, unspecified
0.664 0.336 0.000
G25 Other extrapyramidal and movement disorders
0.664 0.336 0.000
L40-L45 Papulosquamous disorders
0.000 0.338 0.662
G93.3 Postviral fatigue syndrome
0.660 0.340 0.000
M45.X9 Ankylosing spondylitis (Site unspecified)
0.657 0.343 0.000
G03.8 Meningitis due to other specified causes
0.650 0.350 0.000
G03.2 Benign recurrent meningitis [Mollaret]
0.650 0.350 0.000
G03.1 Chronic meningitis
0.650 0.350 0.000
G03.0 Nonpyogenic meningitis
0.650 0.350 0.000
G24.5 Blepharospasm
0.648 0.352 0.000
G24.3 Spasmodic torticollis
0.645 0.354 0.000
G93.5 Compression of brain
0.645 0.355 0.000
G93.1 Anoxic brain damage, not elsewhere classified
0.645 0.355 0.000
G24.8 Other dystonia
0.643 0.357 0.000
G32 Other degenerative disorders of nervous system in diseases classified elsewhere
0.641 0.358 0.000
G91.8 Other hydrocephalus
0.640 0.360 0.000
G91.3 Posttraumatic hydrocephalus, unspecified
0.640 0.360 0.000
G04.8 Other encephalitis, myelitis and encephalomyelitis
0.638 0.362 0.000
E14.3 With ophthalmic complications
0.000 0.363 0.637
G37.8 Other specified demyelinating diseases of central nervous system
0.634 0.366 0.000
G06.0 Intracranial abscess and granuloma
0.632 0.367 0.000
G94 Other disorders of brain in diseases classified elsewhere
0.632 0.367 0.000
G96.0 Cerebrospinal fluid leak
0.628 0.372 0.000
G11 Hereditary ataxia
0.622 0.378 0.000
G00.9 Bacterial meningitis, unspecified
0.617 0.383 0.000
G04.9 Encephalitis, myelitis and encephalomyelitis, unspecified
0.616 0.383 0.000
G97.1 Other reaction to spinal and lumbar puncture
0.616 0.384 0.000
E14.9 Without complications
0.000 0.385 0.615
G90 Disorders of autonomic nervous system
0.614 0.386 0.000
G31.1 Senile degeneration of brain, not elsewhere classified
0.610 0.389 0.000
G06.2 Extradural and subdural abscess, unspecified
0.606 0.394 0.000
G01 Meningitis in bacterial diseases classified elsewhere
0.603 0.397 0.000
G93.7 Reye's syndrome
0.601 0.399 0.000
E16 Other disorders of pancreatic internal secretion
0.000 0.401 0.599
E03.5 Myxoedema coma
0.000 0.401 0.599
E03.4 Atrophy of thyroid (acquired)
0.000 0.401 0.599
E03.3 Postinfectious hypothyroidism
0.000 0.401 0.599
E03.1 Congenital hypothyroidism without goitre
0.000 0.401 0.599
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.401 0.599
G10 Huntington's disease
0.599 0.401 0.000
G24.4 Idiopathic orofacial dystonia
0.597 0.402 0.000
G24.2 Idiopathic nonfamilial dystonia
0.597 0.402 0.000
G24.1 Idiopathic familial dystonia
0.597 0.402 0.000
G24.0 Drug-induced dystonia
0.597 0.402 0.000
G83 Other paralytic syndromes
0.595 0.405 0.000
L43 Lichen planus
0.000 0.407 0.593
E11.1 With ketoacidosis
0.000 0.409 0.591
G96.1 Disorders of meninges, not elsewhere classified
0.587 0.413 0.000
G00.1 Pneumococcal meningitis
0.587 0.413 0.000
G91.2 Normal-pressure hydrocephalus
0.585 0.415 0.000
E11.7 With multiple complications
0.000 0.418 0.582
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.001 0.419 0.580
E00 Congenital iodine-deficiency syndrome
0.001 0.419 0.580
E02 Subclinical iodine-deficiency hypothyroidism
0.001 0.419 0.580
G70-G73 Diseases of myoneural junction and muscle
0.579 0.421 0.000
E13.9 Without complications
0.000 0.421 0.579
G93.6 Cerebral oedema
0.578 0.421 0.000
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.425 0.575
G96.8 Other specified disorders of central nervous system
0.570 0.430 0.000
G04.2 Bacterial meningoencephalitis and meningomyelitis, not elsewhere classified
0.569 0.430 0.000
G04.1 Tropical spastic paraplegia
0.569 0.430 0.000
G04.0 Acute disseminated encephalitis
0.569 0.430 0.000
G93.9 Disorder of brain, unspecified
0.569 0.431 0.000
E03.8 Other specified hypothyroidism
0.000 0.431 0.568
E11.0 With coma
0.000 0.437 0.563
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.437 0.562
K90.3 Pancreatic steatorrhoea
0.000 0.438 0.562
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.438 0.562
K90.1 Tropical sprue
0.000 0.438 0.562
G00.8 Other bacterial meningitis
0.556 0.443 0.000
G00.3 Staphylococcal meningitis
0.556 0.443 0.000
G00.2 Streptococcal meningitis
0.556 0.443 0.000
G00.0 Haemophilus meningitis
0.556 0.443 0.000
E14.8 With unspecified complications
0.000 0.444 0.556
E14.7 With multiple complications
0.000 0.444 0.556
E14.6 With other specified complications
0.000 0.444 0.556
E14.2 Withrenal complications
0.000 0.444 0.556
E14.1 With ketoacidosis
0.000 0.444 0.556
E14.0 With coma
0.000 0.444 0.556
G96.9 Disorder of central nervous system, unspecified
0.556 0.444 0.000
G97.0 Cerebrospinal fluid leak from spinal puncture
0.554 0.446 0.000
K90.8 Other intestinal malabsorption
0.000 0.448 0.552
E83 Disorders of mineral metabolism
0.517 0.449 0.034
E14.4 With neurological complications
0.000 0.452 0.548
E40-E46 Malnutrition
0.001 0.453 0.545
G37.9 Demyelinating disease of central nervous system, unspecified
0.544 0.456 0.000
G13 Systemic atrophies primarily affecting central nervous system in diseases classified elsewhere
0.542 0.458 0.000
G14 Postpolio syndrome
0.542 0.458 0.000
G97.9 Postprocedural disorder of nervous system, unspecified
0.538 0.462 0.000
G97.2 Intracranial hypotension following ventricular shunting
0.538 0.462 0.000
G30 Alzheimer's disease
0.534 0.466 0.000
E16.2 Hypoglycaemia, unspecified
0.000 0.467 0.533
G05.1 Encephalitis, myelitis and encephalomyelitis in viral diseases classified elsewhere
0.532 0.468 0.000
G37.5 Concentric sclerosis [Balo]
0.532 0.468 0.000
G37.4 Subacute necrotising myelitis
0.532 0.468 0.000
G37.2 Central pontine myelinolysis
0.532 0.468 0.000
G37.1 Central demyelination of corpus callosum
0.532 0.468 0.000
G37.0 Diffuse sclerosis
0.532 0.468 0.000
G11.4 Hereditary spastic paraplegia
0.528 0.472 0.000
L43.9 Lichen planus, unspecified
0.000 0.474 0.526
G31.0 Circumscribed brain atrophy
0.524 0.476 0.000
E11.8 With unspecified complications
0.000 0.476 0.524
E07 Other disorders of thyroid
0.000 0.477 0.522
G80 Infantile cerebral palsy
0.522 0.478 0.000
E14.5 With peripheral circulatory complications
0.000 0.482 0.518
G82 Paraplegia and tetraplegia
0.517 0.483 0.000
G93.2 Benign intracranial hypertension
0.517 0.483 0.000
G97.8 Other postprocedural disorders of nervous system
0.514 0.486 0.000
G25.9 Extrapyramidal and movement disorder, unspecified
0.514 0.486 0.000
G95 Other diseases of spinal cord
0.513 0.487 0.000
G05.8 Encephalitis, myelitis and encephalomyelitis in other diseases classified elsewhere
0.512 0.488 0.000
G05.2 Encephalitis, myelitis and encephalomyelitis in other infectious and parasitic diseases classified elsewhere
0.512 0.488 0.000
G05.0 Encephalitis, myelitis and encephalomyelitis in bacterial diseases classified elsewhere
0.512 0.488 0.000
E70-E90 Metabolic disorders
0.011 0.489 0.500
G83.9 Paralytic syndrome, unspecified
0.509 0.491 0.000
G36.9 Acute disseminated demyelination, unspecified
0.508 0.491 0.000
G36.8 Other specified acute disseminated demyelination
0.508 0.491 0.000
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.508 0.491 0.000
G36.0 Neuromyelitis optica [Devic]
0.508 0.491 0.000
L42 Pityriasis rosea
0.000 0.493 0.507
E78.0 Pure hypercholesterolaemia
0.000 0.497 0.503
E11.2 With renal complications
0.000 0.497 0.503
E13.8 With unspecified complications
0.000 0.497 0.503
E13.7 With multiple complications
0.000 0.497 0.503
E13.6 With other specified complications
0.000 0.497 0.503
E13.5 With peripheral circulatory complications
0.000 0.497 0.503
E13.4 With neurological complications
0.000 0.497 0.503
E13.2 With renal complications
0.000 0.497 0.503
E13.1 With ketoacidosis
0.000 0.497 0.503
E13.0 With coma
0.000 0.497 0.503
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.001 0.501 0.498
G02.8 Meningitis in other specified infectious and parasitic diseases classified elsewhere
0.497 0.503 0.000
G02.1 Meningitis in mycoses
0.497 0.503 0.000
G02.0 Meningitis in viral diseases classified elsewhere
0.497 0.503 0.000
G90.9 Disorder of autonomic nervous system, unspecified
0.495 0.505 0.000
E15 Nondiabetic hypoglycaemic coma
0.001 0.507 0.492
G21.9 Secondary Parkinsonism, unspecified
0.489 0.510 0.000
G21.8 Other secondary Parkinsonism
0.489 0.510 0.000
G21.4 Vascular parkinsonism
0.489 0.510 0.000
G21.3 Postencephalitic Parkinsonism
0.489 0.510 0.000
G21.2 Secondary Parkinsonism due to other external agents
0.489 0.510 0.000
G21.1 Other drug-induced secondary Parkinsonism
0.489 0.510 0.000
G21.0 Malignant neuroleptic syndrome
0.489 0.510 0.000
G23.9 Degenerative disease of basal ganglia, unspecified
0.489 0.510 0.000
G23.8 Other specified degenerative diseases of basal ganglia
0.489 0.510 0.000
G23.3 Multiple system atrophy, cerebellar type
0.489 0.510 0.000
G23.2 Striatonigral degeneration
0.489 0.510 0.000
G23.1 Progressive supranuclear ophthalmoplegia [Steele-Richardson-Olszewski]
0.489 0.510 0.000
G23.0 Hallervorden-Spatz disease
0.489 0.510 0.000
E12.9 Without complications
0.000 0.514 0.486
E12.8 With unspecified complications
0.000 0.514 0.486
E12.7 With multiple complications
0.000 0.514 0.486
E12.6 With other specified complications
0.000 0.514 0.486
E12.5 With peripheral circulatory complications
0.000 0.514 0.486
E12.4 With neurological complications
0.000 0.514 0.486
E12.3 With ophthalmic complications
0.000 0.514 0.486
E12.2 With renal complications
0.000 0.514 0.486
E12.1 With ketoacidosis
0.000 0.514 0.486
E12.0 With coma
0.000 0.514 0.486
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.516 0.484
G25.0 Essential tremor
0.482 0.518 0.000
G25.6 Drug-induced tics and other tics of organic origin
0.476 0.524 0.000
G25.5 Other chorea
0.476 0.524 0.000
G25.4 Drug-induced chorea
0.476 0.524 0.000
G25.2 Other specified forms of tremor
0.476 0.524 0.000
G25.1 Drug-induced tremor
0.476 0.524 0.000
L44 Other papulosquamous disorders
0.000 0.525 0.475
L41 Parapsoriasis
0.000 0.525 0.475
L45 Papulosquamous disorders in diseases classified elsewhere
0.000 0.525 0.475
G82.1 Spastic paraplegia
0.474 0.526 0.000
E78.2 Mixed hyperlipidaemia
0.000 0.529 0.471
G83.1 Monoplegia of lower limb
0.469 0.531 0.000
L43.8 Other lichen planus
0.000 0.533 0.467
G25.8 Other specified extrapyramidal and movement disorders
0.465 0.535 0.000
E11.3 With ophthalmic complications
0.000 0.539 0.461
G32.8 Other specified degenerative disorders of nervous system in diseases classified elsewhere
0.460 0.540 0.000
G32.0 Subacute combined degeneration of spinal cord in diseases classified elsewhere
0.460 0.540 0.000
E06 Thyroiditis
0.001 0.544 0.455
G94.8 Other specified disorders of brain in diseases classified elsewhere
0.453 0.546 0.000
G94.2 Hydrocephalus in other diseases classified elsewhere
0.453 0.546 0.000
G94.0 Hydrocephalus in infectious and parasitic diseases classified elsewhere
0.453 0.546 0.000
M45 Ankylosing spondylitis
0.453 0.547 0.000
G95.0 Syringomyelia and syringobulbia
0.449 0.551 0.000
G83.8 Other specified paralytic syndromes
0.447 0.553 0.000
G11.8 Other hereditary ataxias
0.446 0.554 0.000
G11.3 Cerebellar ataxia with defective DNA repair
0.446 0.554 0.000
G11.2 Late-onset cerebellar ataxia
0.446 0.554 0.000
G11.1 Early-onset cerebellar ataxia
0.446 0.554 0.000
G11.0 Congenital nonprogressive ataxia
0.446 0.554 0.000
G11.9 Hereditary ataxia, unspecified
0.442 0.558 0.000
G90.3 Multisystem degeneration
0.441 0.558 0.000
G93.0 Cerebral cysts
0.440 0.560 0.000
G90.8 Other disorders of autonomic nervous system
0.440 0.560 0.000
G90.4 Autonomic dysreflexia
0.440 0.560 0.000
G90.1 Familial dysautonomia [Riley-Day]
0.440 0.560 0.000
E83.3 Disorders of phosphorus metabolism
0.426 0.560 0.014
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.562 0.437
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.570 0.429
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.570 0.429
E16.4 Abnormal secretion of gastrin
0.000 0.570 0.429
E16.3 Increased secretion of glucagon
0.000 0.570 0.429
E16.1 Other hypoglycaemia
0.000 0.570 0.429
G83.5 Locked-in syndrome
0.427 0.573 0.000
G83.3 Monoplegia, unspecified
0.427 0.573 0.000
G83.0 Diplegia of upper limbs
0.427 0.573 0.000
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system
0.426 0.574 0.000
L43.3 Subacute (active) lichen planus
0.000 0.575 0.425
L43.2 Lichenoid drug reaction
0.000 0.575 0.425
L43.1 Bullous lichen planus
0.000 0.575 0.425
L43.0 Hypertrophic lichen planus
0.000 0.575 0.425
G72 Other myopathies
0.420 0.580 0.000
G99 Other disorders of nervous system in diseases classified elsewhere
0.420 0.580 0.000
E13.3 With ophthalmic complications
0.000 0.583 0.416
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.001 0.584 0.416
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.001 0.584 0.416
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.001 0.584 0.416
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.001 0.584 0.416
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.001 0.584 0.416
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.001 0.584 0.416
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.001 0.584 0.416
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.001 0.584 0.416
G73 Disorders of myoneural junction and muscle in diseases classified elsewhere
0.415 0.584 0.000
E85 Amyloidosis
0.006 0.586 0.408
E05.8 Other thyrotoxicosis
0.000 0.588 0.412
E05.5 Thyroid crisis or storm
0.000 0.588 0.412
E05.4 Thyrotoxicosis factitia
0.000 0.588 0.412
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.588 0.412
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.588 0.412
G94.1 Hydrocephalus in neoplastic disease
0.412 0.588 0.000
G25.3 Myoclonus
0.411 0.589 0.000
G83.4 Cauda equina syndrome
0.409 0.591 0.000
G12 Spinal muscular atrophy and related syndromes
0.405 0.595 0.000
E07.8 Other specified disorders of thyroid
0.000 0.596 0.403
G30.8 Other Alzheimer's disease
0.403 0.597 0.000
G30.0 Alzheimer's disease with early onset
0.403 0.597 0.000
E74 Other disorders of carbohydrate metabolism
0.007 0.598 0.395
E83.9 Disorder of mineral metabolism, unspecified
0.371 0.605 0.025
E83.8 Other disorders of mineral metabolism
0.371 0.605 0.025
E83.2 Disorders of zinc metabolism
0.371 0.605 0.025
E83.0 Disorders of copper metabolism
0.371 0.605 0.025
E44 Protein-energy malnutrition of moderate and mild degree
0.001 0.608 0.391
E45 Retarded development following protein-energy malnutrition
0.001 0.608 0.391
E43 Unspecified severe protein-energy malnutrition
0.001 0.608 0.391
E42 Marasmic kwashiorkor
0.001 0.608 0.391
E41 Nutritional marasmus
0.001 0.608 0.391
E40 Kwashiorkor
0.001 0.608 0.391
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.391 0.608 0.000
E11.4 With neurological complications
0.000 0.611 0.389
G13.8 Systemic atrophy primarily affecting central nervous system in other diseases classified elsewhere
0.389 0.611 0.000
G13.2 Systemic atrophy primarily affecting central nervous system in myxoedema
0.389 0.611 0.000
G13.1 Other systemic atrophy primarily affecting central nervous system in neoplastic disease
0.389 0.611 0.000
G13.0 Paraneoplastic neuromyopathy and neuropathy
0.389 0.611 0.000
G80.9 Infantile cerebral palsy, unspecified
0.388 0.612 0.000
G30.1 Alzheimer's disease with late onset
0.383 0.617 0.000
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.379 0.620 0.000
G83.2 Monoplegia of upper limb
0.377 0.623 0.000
G71 Primary disorders of muscles
0.376 0.623 0.000
E07.1 Dyshormogenetic goitre
0.000 0.625 0.375
E07.0 Hypersecretion of calcitonin
0.000 0.625 0.375
G80.8 Other infantile cerebral palsy
0.374 0.626 0.000
G80.4 Ataxic cerebral palsy
0.374 0.626 0.000
G80.3 Dyskinetic cerebral palsy
0.374 0.626 0.000
G80.2 Infantile hemiplegia
0.374 0.626 0.000
G80.1 Spastic diplegia
0.374 0.626 0.000
G80.0 Spastic cerebral palsy
0.374 0.626 0.000
G90.2 Horner's syndrome
0.373 0.627 0.000
G82.4 Spastic tetraplegia
0.371 0.629 0.000
G82.3 Flaccid tetraplegia
0.371 0.629 0.000
G82.0 Flaccid paraplegia
0.371 0.629 0.000
E84 Cystic fibrosis
0.008 0.633 0.359
E79 Disorders of purine and pyrimidine metabolism
0.008 0.633 0.359
E77 Disorders of glycoprotein metabolism
0.008 0.633 0.359
E76 Disorders of glycosaminoglycan metabolism
0.008 0.633 0.359
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.008 0.633 0.359
E72 Other disorders of amino-acid metabolism
0.008 0.633 0.359
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.008 0.633 0.359
E70 Disorders of aromatic amino-acid metabolism
0.008 0.633 0.359
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.008 0.633 0.359
G90.0 Idiopathic peripheral autonomic neuropathy
0.365 0.634 0.000
E78.8 Other disorders of lipoprotein metabolism
0.001 0.636 0.363
E78.4 Other hyperlipidaemia
0.001 0.640 0.359
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.641 0.359
E78.6 Lipoprotein deficiency
0.001 0.642 0.357
E78.3 Hyperchylomicronaemia
0.001 0.642 0.357
E46 Unspecified protein-energy malnutrition
0.001 0.643 0.356
G95.9 Disease of spinal cord, unspecified
0.349 0.651 0.000
E83.5 Disorders of calcium metabolism
0.343 0.652 0.005
E05.9 Thyrotoxicosis, unspecified
0.000 0.652 0.348
G60 Hereditary and idiopathic neuropathy
0.347 0.653 0.000
E73 Lactose intolerance
0.008 0.654 0.339
E20-E35 Disorders of other endocrine glands
0.001 0.656 0.343
E85.9 Amyloidosis, unspecified
0.003 0.659 0.338
L41.9 Parapsoriasis, unspecified
0.000 0.659 0.341
L41.8 Other parapsoriasis
0.000 0.659 0.341
L41.5 Retiform parapsoriasis
0.000 0.659 0.341
L41.4 Large plaque parapsoriasis
0.000 0.659 0.341
L41.3 Small plaque parapsoriasis
0.000 0.659 0.341
L41.2 Lymphomatoid papulosis
0.000 0.659 0.341
L41.1 Pityriasis lichenoides chronica
0.000 0.659 0.341
L41.0 Pityriasis lichenoides et varioliformis acuta
0.000 0.659 0.341
L44.9 Papulosquamous disorder, unspecified
0.000 0.659 0.341
L44.8 Other specified papulosquamous disorders
0.000 0.659 0.341
L44.4 Infantile papular acrodermatitis [Giannotti-Crosti]
0.000 0.659 0.341
L44.3 Lichen ruber moniliformis
0.000 0.659 0.341
L44.2 Lichen striatus
0.000 0.659 0.341
L44.1 Lichen nitidus
0.000 0.659 0.341
L44.0 Pityriasis rubra pilaris
0.000 0.659 0.341
G70 Myasthenia gravis and other myoneural disorders
0.339 0.661 0.000
K51.9 Ulcerative colitis, unspecified
0.331 0.669 0.000
G31.8 Other specified degenerative diseases of nervous system
0.329 0.670 0.001
E06.5 Other chronic thyroiditis
0.001 0.673 0.326
E06.4 Drug-induced thyroiditis
0.001 0.673 0.326
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.001 0.673 0.326
E06.1 Subacute thyroiditis
0.001 0.673 0.326
E06.0 Acute thyroiditis
0.001 0.673 0.326
K51 Ulcerative colitis
0.326 0.674 0.000
M45.X2 Ankylosing spondylitis (Cervical region)
0.326 0.674 0.000
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)
0.325 0.675 0.000
M45.X7 Ankylosing spondylitis (Lumbosacral region)
0.325 0.675 0.000
M45.X6 Ankylosing spondylitis (Lumbar region)
0.325 0.675 0.000
M45.X5 Ankylosing spondylitis (Thoracolumbar region)
0.325 0.675 0.000
M45.X4 Ankylosing spondylitis (Thoracic region)
0.325 0.675 0.000
M45.X3 Ankylosing spondylitis (Cervicothoracic region)
0.325 0.675 0.000
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)
0.325 0.675 0.000
E74.3 Other disorders of intestinal carbohydrate absorption
0.004 0.676 0.320
G81 Hemiplegia
0.320 0.680 0.000
G72.9 Myopathy, unspecified
0.311 0.689 0.000
G82.5 Tetraplegia, unspecified
0.310 0.690 0.000
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.692 0.307
G95.8 Other specified diseases of spinal cord
0.305 0.695 0.000
G64 Other disorders of peripheral nervous system
0.305 0.695 0.000
E83.4 Disorders of magnesium metabolism
0.287 0.695 0.018
E85.4 Organ-limited amyloidosis
0.004 0.695 0.301
E06.9 Thyroiditis, unspecified
0.001 0.698 0.302
G72.8 Other specified myopathies
0.301 0.698 0.000
G72.3 Periodic paralysis
0.301 0.698 0.000
G72.2 Myopathy due to other toxic agents
0.301 0.698 0.000
G72.1 Alcoholic myopathy
0.301 0.698 0.000
G72.0 Drug-induced myopathy
0.301 0.698 0.000
G99.8 Other specified disorders of nervous system in diseases classified elsewhere
0.301 0.699 0.000
G99.1 Other disorders of autonomic nervous system in other diseases classified elsewhere
0.301 0.699 0.000
G73.7 Myopathy other diseases classified elsewhere
0.298 0.702 0.000
G73.6 Myopathy in metabolic diseases
0.298 0.702 0.000
G73.5 Myopathy in endocrine diseases
0.298 0.702 0.000
G73.4 Myopathy in infectious and parasitic diseases classified elsewhere
0.298 0.702 0.000
G73.3 Myasthenic syndromes in other diseases classified elsewhere
0.298 0.702 0.000
G73.2 Other myasthenic syndromes in neoplastic disease
0.298 0.702 0.000
G73.1 Eaton-Lambert syndrome
0.298 0.702 0.000
G73.0 Myasthenic syndromes in endocrine diseases
0.298 0.702 0.000
K51.8 Other ulcerative colitis
0.298 0.702 0.000
E85.8 Other amyloidosis
0.004 0.703 0.293
E85.3 Secondary systemic amyloidosis
0.004 0.703 0.293
E85.2 Heredofamilial amyloidosis, unspecified
0.004 0.703 0.293
E85.1 Neuropathic heredofamilial amyloidosis
0.004 0.703 0.293
E85.0 Nonneuropathic heredofamilial amyloidosis
0.004 0.703 0.293
E24 Cushing's syndrome
0.000 0.703 0.296
G72.4 Inflammatory myopathy, not elsewhere classified
0.296 0.704 0.000
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.004 0.709 0.286
G12.9 Spinal muscular atrophy, unspecified
0.290 0.709 0.000
G12.8 Other spinal muscular atrophies and related syndromes
0.290 0.709 0.000
G12.1 Other inherited spinal muscular atrophy
0.290 0.709 0.000
G12.0 Infantile spinal muscular atrophy, type I [Werdnig-Hoffman]
0.290 0.709 0.000
E21.0 Primary hyperparathyroidism
0.000 0.711 0.289
E74.9 Disorder of carbohydrate metabolism, unspecified
0.005 0.711 0.284
E74.8 Other specified disorders of carbohydrate metabolism
0.005 0.711 0.284
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.005 0.711 0.284
E74.2 Disorders of galactose metabolism
0.005 0.711 0.284
E74.1 Disorders of fructose metabolism
0.005 0.711 0.284
E74.0 Glycogen storage disease
0.005 0.711 0.284
G60.8 Other hereditary and idiopathic neuropathies
0.287 0.713 0.000
G95.1 Vascular myelopathies
0.287 0.713 0.000
E88 Other metabolic disorders
0.008 0.714 0.278
K51.3 Ulcerative (chronic) rectosigmoiditis
0.282 0.718 0.000
E44.1 Mild protein-energy malnutrition
0.001 0.719 0.280
E44.0 Moderate protein-energy malnutrition
0.001 0.719 0.280
K51.5 Mucosal proctocolitis
0.280 0.720 0.000
G71.9 Primary disorder of muscle, unspecified
0.270 0.730 0.000
G71.8 Other primary disorders of muscles
0.270 0.730 0.000
G71.3 Mitochondrial myopathy, not elsewhere classified
0.270 0.730 0.000
G71.2 Congenital myopathies
0.270 0.730 0.000
K51.4 Pseudopolyposis of colon
0.269 0.731 0.000
E07.9 Disorder of thyroid, unspecified
0.000 0.733 0.267
G63 Polyneuropathy in diseases classified elsewhere
0.266 0.734 0.000
E24.9 Cushing's syndrome, unspecified
0.000 0.737 0.263
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.006 0.737 0.257
E70.8 Other disorders of aromatic amino-acid metabolism
0.006 0.737 0.257
E70.3 Albinism
0.006 0.737 0.257
E70.2 Disorders of tyrosine metabolism
0.006 0.737 0.257
E70.1 Other hyperphenylalaninaemias
0.006 0.737 0.257
E70.0 Classical phenylketonuria
0.006 0.737 0.257
E71.3 Disorders of fatty-acid metabolism
0.006 0.737 0.257
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.006 0.737 0.257
E71.1 Other disorders of branched-chain amino-acid metabolism
0.006 0.737 0.257
E71.0 Maple-syrup-urine disease
0.006 0.737 0.257
E72.9 Disorder of amino-acid metabolism, unspecified
0.006 0.737 0.257
E72.8 Other specified disorders of amino-acid metabolism
0.006 0.737 0.257
E72.5 Disorders of glycine metabolism
0.006 0.737 0.257
E72.4 Disorders of ornithine metabolism
0.006 0.737 0.257
E72.3 Disorders of lysine and hydroxylysine metabolism
0.006 0.737 0.257
E72.2 Disorders of urea cycle metabolism
0.006 0.737 0.257
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.006 0.737 0.257
E72.0 Disorders of amino-acid transport
0.006 0.737 0.257
E75.6 Lipid storage disorder, unspecified
0.006 0.737 0.257
E75.5 Other lipid storage disorders
0.006 0.737 0.257
E75.4 Neuronal ceroid lipofuscinosis
0.006 0.737 0.257
E75.3 Sphingolipidosis, unspecified
0.006 0.737 0.257
E75.2 Other sphingolipidosis
0.006 0.737 0.257
E75.1 Other gangliosidosis
0.006 0.737 0.257
E75.0 GM2 gangliosidosis
0.006 0.737 0.257
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.006 0.737 0.257
E76.8 Other disorders of glucosaminoglycan metabolism
0.006 0.737 0.257
E76.3 Mucopolysaccharidosis, unspecified
0.006 0.737 0.257
E76.2 Other mucopolysaccharidoses
0.006 0.737 0.257
E76.1 Mucopolysaccharidosis, type II
0.006 0.737 0.257
E76.0 Mucopolysaccharidosis, type I
0.006 0.737 0.257
E77.9 Disorder of glycoprotein metabolism, unspecified
0.006 0.737 0.257
E77.8 Other disorders of glycoprotein metabolism
0.006 0.737 0.257
E77.1 Defects in glycoprotein degradation
0.006 0.737 0.257
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.006 0.737 0.257
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.006 0.737 0.257

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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