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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2233977
log Bayes Factor = 30.0536
Chromosome 6   position 31,079,894  (GRCh37) Explore rs2233977 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
K90.0 Coeliac disease
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.003 0.997
M45.X9 Ankylosing spondylitis (Site unspecified)
0.993 0.007 0.000
E10-E14 Diabetes mellitus
0.000 0.008 0.992
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.011 0.989
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.013 0.987
E16 Other disorders of pancreatic internal secretion
0.000 0.014 0.986
E16.2 Hypoglycaemia, unspecified
0.000 0.015 0.985
E00-E07 Disorders of thyroid gland
0.002 0.019 0.980
E03.9 Hypothyroidism, unspecified
0.978 0.022 0.000
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.023 0.977
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.024 0.976
E10.1 With ketoacidosis
0.000 0.025 0.975
G35 Multiple sclerosis
0.000 0.030 0.970
E10.9 Without complications
0.000 0.031 0.969
E10.2 With renal complications
0.000 0.059 0.941
L40.9 Psoriasis, unspecified
0.000 0.060 0.940
L40 Psoriasis
0.000 0.066 0.934
L40.5 Arthropathic psoriasis
0.000 0.071 0.929
E06 Thyroiditis
0.001 0.104 0.896
M45 Ankylosing spondylitis
0.889 0.111 0.000
L40.0 Psoriasis vulgaris
0.000 0.156 0.844
E03 Other hypothyroidism
0.672 0.171 0.157
E06.9 Thyroiditis, unspecified
0.000 0.188 0.811
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.803 0.197 0.000
E65-E68 Obesity and other hyperalimentation
0.000 0.201 0.799
E05.8 Other thyrotoxicosis
0.000 0.203 0.797
E10.5 With peripheral circulatory complications
0.000 0.215 0.785
E10.8 With unspecified complications
0.000 0.217 0.783
E16.1 Other hypoglycaemia
0.000 0.228 0.772
M45.X2 Ankylosing spondylitis (Cervical region)
0.767 0.233 0.000
E10.4 With neurological complications
0.000 0.252 0.748
M45.X6 Ankylosing spondylitis (Lumbar region)
0.743 0.257 0.000
E13 Other specified diabetes mellitus
0.000 0.266 0.734
E10.6 With other specified complications
0.000 0.272 0.728
E50-E64 Other nutritional deficiencies
0.000 0.273 0.727
E10.7 With multiple complications
0.000 0.283 0.717
E06.3 Autoimmune thyroiditis
0.000 0.285 0.715
E12 Malnutrition-related diabetes mellitus
0.000 0.289 0.711
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.290 0.710
E15 Nondiabetic hypoglycaemic coma
0.000 0.292 0.708
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.293 0.707
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.293 0.707
E16.4 Abnormal secretion of gastrin
0.000 0.293 0.707
E16.3 Increased secretion of glucagon
0.000 0.293 0.707
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.001 0.296 0.703
E00 Congenital iodine-deficiency syndrome
0.001 0.296 0.703
E02 Subclinical iodine-deficiency hypothyroidism
0.001 0.296 0.703
E10.0 With coma
0.000 0.299 0.701
E05.5 Thyroid crisis or storm
0.000 0.299 0.701
E05.4 Thyrotoxicosis factitia
0.000 0.299 0.701
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.299 0.701
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.299 0.701
E11 Non-insulin-dependent diabetes mellitus
0.000 0.316 0.684
L40.1 Generalised pustular psoriasis
0.000 0.328 0.672
L40.4 Guttate psoriasis
0.000 0.330 0.670
L40.3 Pustulosis palmaris et plantaris
0.000 0.330 0.670
L40.2 Acrodermatitis continua
0.000 0.330 0.670
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.338 0.662
E65 Localised adiposity
0.000 0.354 0.646
E55 Vitamin D deficiency
0.000 0.356 0.644
E06.5 Other chronic thyroiditis
0.001 0.357 0.642
E06.4 Drug-induced thyroiditis
0.001 0.357 0.642
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.001 0.357 0.642
E06.1 Subacute thyroiditis
0.001 0.357 0.642
E06.0 Acute thyroiditis
0.001 0.357 0.642
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)
0.637 0.363 0.000
M45.X7 Ankylosing spondylitis (Lumbosacral region)
0.637 0.363 0.000
M45.X5 Ankylosing spondylitis (Thoracolumbar region)
0.637 0.363 0.000
M45.X4 Ankylosing spondylitis (Thoracic region)
0.637 0.363 0.000
M45.X3 Ankylosing spondylitis (Cervicothoracic region)
0.637 0.363 0.000
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)
0.637 0.363 0.000
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.547 0.367 0.086
E40-E46 Malnutrition
0.000 0.402 0.598
E03.8 Other specified hypothyroidism
0.509 0.402 0.088
E66 Obesity
0.000 0.404 0.596
E03.5 Myxoedema coma
0.482 0.406 0.112
E03.4 Atrophy of thyroid (acquired)
0.482 0.406 0.112
E03.3 Postinfectious hypothyroidism
0.482 0.406 0.112
E03.1 Congenital hypothyroidism without goitre
0.482 0.406 0.112
E03.0 Congenital hypothyroidism with diffuse goitre
0.482 0.406 0.112
E11.3 With ophthalmic complications
0.000 0.408 0.592
E55.9 Vitamin D deficiency, unspecified
0.000 0.416 0.584
E11.6 With other specified complications
0.000 0.426 0.574
E67 Other hyperalimentation
0.000 0.427 0.573
E68 Sequelae of hyperalimentation
0.000 0.427 0.573
L40.8 Other psoriasis
0.000 0.429 0.571
K90 Intestinal malabsorption
0.000 0.429 0.571
G35-G37 Demyelinating diseases of the central nervous system
0.000 0.438 0.562
E05.9 Thyrotoxicosis, unspecified
0.000 0.441 0.559
E11.4 With neurological complications
0.000 0.450 0.550
E13.9 Without complications
0.000 0.451 0.549
E66.8 Other obesity
0.000 0.466 0.534
E13.8 With unspecified complications
0.000 0.474 0.526
E13.7 With multiple complications
0.000 0.474 0.526
E13.6 With other specified complications
0.000 0.474 0.526
E13.5 With peripheral circulatory complications
0.000 0.474 0.526
E13.4 With neurological complications
0.000 0.474 0.526
E13.3 With ophthalmic complications
0.000 0.474 0.526
E13.2 With renal complications
0.000 0.474 0.526
E13.1 With ketoacidosis
0.000 0.474 0.526
E13.0 With coma
0.000 0.474 0.526
E11.8 With unspecified complications
0.000 0.476 0.524
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.479 0.521
E63 Other nutritional deficiencies
0.000 0.479 0.521
E51 Thiamine deficiency
0.000 0.479 0.521
E50 Vitamin A deficiency
0.000 0.479 0.521
E60 Dietary zinc deficiency
0.000 0.479 0.521
E59 Dietary selenium deficiency
0.000 0.479 0.521
E58 Dietary calcium deficiency
0.000 0.479 0.521
E54 Ascorbic acid deficiency
0.000 0.479 0.521
E52 Niacin deficiency [pellagra]
0.000 0.479 0.521
E11.2 With renal complications
0.000 0.490 0.510
E12.9 Without complications
0.000 0.490 0.510
E12.8 With unspecified complications
0.000 0.490 0.510
E12.7 With multiple complications
0.000 0.490 0.510
E12.6 With other specified complications
0.000 0.490 0.510
E12.5 With peripheral circulatory complications
0.000 0.490 0.510
E12.4 With neurological complications
0.000 0.490 0.510
E12.3 With ophthalmic complications
0.000 0.490 0.510
E12.2 With renal complications
0.000 0.490 0.510
E12.1 With ketoacidosis
0.000 0.490 0.510
E12.0 With coma
0.000 0.490 0.510
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.001 0.495 0.504
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.001 0.495 0.504
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.001 0.495 0.504
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.001 0.495 0.504
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.001 0.495 0.504
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.001 0.495 0.504
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.001 0.495 0.504
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.001 0.495 0.504
E11.7 With multiple complications
0.000 0.509 0.490
G37 Other demyelinating diseases of central nervous system
0.000 0.513 0.487
E61 Deficiency of other nutrient elements
0.000 0.516 0.484
E55.0 Rickets, active
0.000 0.538 0.462
E07 Other disorders of thyroid
0.002 0.542 0.456
E66.0 Obesity due to excess calories
0.000 0.543 0.457
E56 Other vitamin deficiencies
0.000 0.543 0.457
E66.2 Extreme obesity with alveolar hypoventilation
0.000 0.543 0.457
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.547 0.453
L40-L45 Papulosquamous disorders
0.000 0.552 0.448
K90.9 Intestinal malabsorption, unspecified
0.000 0.558 0.442
E11.1 With ketoacidosis
0.000 0.567 0.433
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.571 0.429
E45 Retarded development following protein-energy malnutrition
0.000 0.571 0.429
E43 Unspecified severe protein-energy malnutrition
0.000 0.571 0.429
E42 Marasmic kwashiorkor
0.000 0.571 0.429
E41 Nutritional marasmus
0.000 0.571 0.429
E40 Kwashiorkor
0.000 0.571 0.429
E11.0 With coma
0.000 0.572 0.427
E66.1 Drug-induced obesity
0.000 0.572 0.427
E53 Deficiency of other B group vitamins
0.000 0.573 0.427
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.000 0.580 0.420
E11.5 With peripheral circulatory complications
0.000 0.581 0.419
E67.8 Other specified hyperalimentation
0.000 0.589 0.411
E67.3 Hypervitaminosis D
0.000 0.589 0.411
E67.2 Megavitamin-B6 syndrome
0.000 0.589 0.411
E67.1 Hypercarotenaemia
0.000 0.589 0.411
E67.0 Hypervitaminosis A
0.000 0.589 0.411
K90.8 Other intestinal malabsorption
0.000 0.589 0.410
K90.3 Pancreatic steatorrhoea
0.000 0.590 0.409
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.590 0.409
K90.1 Tropical sprue
0.000 0.590 0.409
G36 Other acute disseminated demyelination
0.000 0.612 0.388
G37.9 Demyelinating disease of central nervous system, unspecified
0.000 0.613 0.386
E50.9 Vitamin A deficiency, unspecified
0.000 0.626 0.374
E50.8 Other manifestations of vitamin A deficiency
0.000 0.626 0.374
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.626 0.374
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.626 0.374
E50.5 Vitamin A deficiency with night blindness
0.000 0.626 0.374
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.626 0.374
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.626 0.374
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.626 0.374
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.626 0.374
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.626 0.374
E51.9 Thiamine deficiency, unspecified
0.000 0.626 0.374
E51.8 Other manifestations of thiamine deficiency
0.000 0.626 0.374
E51.2 Wernicke's encephalopathy
0.000 0.626 0.374
E51.1 Beriberi
0.000 0.626 0.374
E63.9 Nutritional deficiency, unspecified
0.000 0.626 0.374
E63.8 Other specified nutritional deficiencies
0.000 0.626 0.374
E63.1 Imbalance of constituents of food intake
0.000 0.626 0.374
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.626 0.374
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.626 0.374
E64.8 Sequelae of other nutritional deficiencies
0.000 0.626 0.374
E64.3 Sequelae of rickets
0.000 0.626 0.374
E64.2 Sequelae of vitamin C deficiency
0.000 0.626 0.374
E64.1 Sequelae of vitamin A deficiency
0.000 0.626 0.374
E64.0 Sequelae of protein-energy malnutrition
0.000 0.626 0.374
E14 Unspecified diabetes mellitus
0.000 0.629 0.371
L42 Pityriasis rosea
0.000 0.641 0.359
G37.5 Concentric sclerosis [Balo]
0.000 0.651 0.349
G37.4 Subacute necrotising myelitis
0.000 0.651 0.349
G37.2 Central pontine myelinolysis
0.000 0.651 0.349
G37.1 Central demyelination of corpus callosum
0.000 0.651 0.349
G37.0 Diffuse sclerosis
0.000 0.651 0.349
E61.2 Magnesium deficiency
0.000 0.652 0.348
E61.9 Deficiency of nutrient element, unspecified
0.000 0.653 0.347
E61.8 Deficiency of other specified nutrient elements
0.000 0.653 0.347
E61.7 Deficiency of multiple nutrient elements
0.000 0.653 0.347
E61.6 Vanadium deficiency
0.000 0.653 0.347
E61.5 Molybdenum deficiency
0.000 0.653 0.347
E61.4 Chromium deficiency
0.000 0.653 0.347
E61.3 Manganese deficiency
0.000 0.653 0.347
E61.0 Copper deficiency
0.000 0.653 0.347
G37.8 Other specified demyelinating diseases of central nervous system
0.000 0.664 0.336
E53.9 Vitamin B deficiency, unspecified
0.000 0.666 0.334
E07.1 Dyshormogenetic goitre
0.001 0.672 0.327
E07.0 Hypersecretion of calcitonin
0.001 0.672 0.327
E56.9 Vitamin deficiency, unspecified
0.000 0.672 0.328
E56.8 Deficiency of other vitamins
0.000 0.672 0.328
E56.0 Deficiency of vitamin E
0.000 0.672 0.328
E07.8 Other specified disorders of thyroid
0.001 0.674 0.325
L44 Other papulosquamous disorders
0.000 0.678 0.322
L41 Parapsoriasis
0.000 0.678 0.322
L45 Papulosquamous disorders in diseases classified elsewhere
0.000 0.678 0.322
E46 Unspecified protein-energy malnutrition
0.000 0.682 0.318
L43 Lichen planus
0.000 0.691 0.309
E44.1 Mild protein-energy malnutrition
0.000 0.692 0.308
E44.0 Moderate protein-energy malnutrition
0.000 0.692 0.308
E61.1 Iron deficiency
0.000 0.692 0.308
E53.1 Pyridoxine deficiency
0.000 0.694 0.306
E53.0 Riboflavin deficiency
0.000 0.694 0.306
E70-E90 Metabolic disorders
0.000 0.712 0.288
E14.4 With neurological complications
0.000 0.713 0.287
M06.9 Rheumatoid arthritis, unspecified
0.283 0.717 0.000
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.280 0.720 0.000
G36.9 Acute disseminated demyelination, unspecified
0.000 0.721 0.278
G36.8 Other specified acute disseminated demyelination
0.000 0.721 0.278
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.000 0.721 0.278
E83.1 Disorders of iron metabolism
0.000 0.724 0.276
E83 Disorders of mineral metabolism
0.000 0.725 0.275
E14.1 With ketoacidosis
0.000 0.733 0.267
E14.8 With unspecified complications
0.000 0.734 0.266
E14.7 With multiple complications
0.000 0.734 0.266
E14.2 Withrenal complications
0.000 0.734 0.266
E14.0 With coma
0.000 0.734 0.266
E56.1 Deficiency of vitamin K
0.001 0.736 0.263
G36.0 Neuromyelitis optica [Devic]
0.000 0.737 0.263
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.260 0.740 0.000
M06 Other rheumatoid arthritis
0.259 0.741 0.000
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.255 0.745 0.000
L43.8 Other lichen planus
0.000 0.750 0.250
E14.6 With other specified complications
0.000 0.751 0.249
M06.0 Seronegative rheumatoid arthritis
0.248 0.752 0.000
E14.3 With ophthalmic complications
0.000 0.756 0.243
E85 Amyloidosis
0.000 0.759 0.241
M06.00 Seronegative rheumatoid arthritis (Multiple sites)
0.237 0.763 0.000
E14.5 With peripheral circulatory complications
0.000 0.767 0.233
L41.9 Parapsoriasis, unspecified
0.000 0.769 0.231
L41.8 Other parapsoriasis
0.000 0.769 0.231
L41.5 Retiform parapsoriasis
0.000 0.769 0.231
L41.4 Large plaque parapsoriasis
0.000 0.769 0.231
L41.3 Small plaque parapsoriasis
0.000 0.769 0.231
L41.2 Lymphomatoid papulosis
0.000 0.769 0.231
L41.1 Pityriasis lichenoides chronica
0.000 0.769 0.231
L41.0 Pityriasis lichenoides et varioliformis acuta
0.000 0.769 0.231
L44.9 Papulosquamous disorder, unspecified
0.000 0.769 0.231
L44.8 Other specified papulosquamous disorders
0.000 0.769 0.231
L44.4 Infantile papular acrodermatitis [Giannotti-Crosti]
0.000 0.769 0.231
L44.3 Lichen ruber moniliformis
0.000 0.769 0.231
L44.2 Lichen striatus
0.000 0.769 0.231
L44.1 Lichen nitidus
0.000 0.769 0.231
L44.0 Pityriasis rubra pilaris
0.000 0.769 0.231
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.225 0.775 0.000
M06.3 Rheumatoid nodule
0.224 0.776 0.000
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.223 0.777 0.000
L43.3 Subacute (active) lichen planus
0.000 0.778 0.222
L43.2 Lichenoid drug reaction
0.000 0.778 0.222
L43.1 Bullous lichen planus
0.000 0.778 0.222
L43.0 Hypertrophic lichen planus
0.000 0.778 0.222
E04 Other non-toxic goitre
0.001 0.778 0.221
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.220 0.780 0.000
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.218 0.782 0.000
E83.5 Disorders of calcium metabolism
0.000 0.783 0.217
E84 Cystic fibrosis
0.000 0.793 0.206
E79 Disorders of purine and pyrimidine metabolism
0.000 0.793 0.206
E77 Disorders of glycoprotein metabolism
0.000 0.793 0.206
E76 Disorders of glycosaminoglycan metabolism
0.000 0.793 0.206
E72 Other disorders of amino-acid metabolism
0.000 0.793 0.206
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.793 0.206
E70 Disorders of aromatic amino-acid metabolism
0.000 0.793 0.206
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.793 0.206
M06.98 Rheumatoid arthritis, unspecified (Other)
0.205 0.795 0.000
E85.4 Organ-limited amyloidosis
0.000 0.795 0.205
M06.34 Rheumatoid nodule (Hand)
0.204 0.796 0.000
E88 Other metabolic disorders
0.000 0.799 0.201
E74 Other disorders of carbohydrate metabolism
0.000 0.802 0.197
E83.9 Disorder of mineral metabolism, unspecified
0.000 0.803 0.197
E83.8 Other disorders of mineral metabolism
0.000 0.803 0.197
E83.2 Disorders of zinc metabolism
0.000 0.803 0.197
E83.0 Disorders of copper metabolism
0.000 0.803 0.197
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.805 0.195
M06.07 Seronegative rheumatoid arthritis (Ankle and foot)
0.192 0.808 0.000
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.190 0.810 0.000
M06.8 Other specified rheumatoid arthritis
0.186 0.814 0.000
M06.2 Rheumatoid bursitis
0.186 0.814 0.000
M06.1 Adult-onset Still's disease
0.186 0.814 0.000
M06.09 Seronegative rheumatoid arthritis (Site unspecified)
0.185 0.815 0.000
E73 Lactose intolerance
0.000 0.816 0.184
M06.08 Seronegative rheumatoid arthritis (Other)
0.178 0.822 0.000
M06.06 Seronegative rheumatoid arthritis (Lower leg)
0.178 0.822 0.000
M06.05 Seronegative rheumatoid arthritis (Pelvic region and thigh)
0.178 0.822 0.000
M06.04 Seronegative rheumatoid arthritis (Hand)
0.178 0.822 0.000
M06.03 Seronegative rheumatoid arthritis (Forearm)
0.178 0.822 0.000
M06.02 Seronegative rheumatoid arthritis (Upper arm)
0.178 0.822 0.000
M06.01 Seronegative rheumatoid arthritis (Shoulder region)
0.178 0.822 0.000
M06.4 Inflammatory polyarthropathy
0.177 0.822 0.000
E86 Volume depletion
0.000 0.823 0.177
E85.9 Amyloidosis, unspecified
0.000 0.824 0.176
E85.8 Other amyloidosis
0.000 0.827 0.173
E85.3 Secondary systemic amyloidosis
0.000 0.827 0.173
E85.2 Heredofamilial amyloidosis, unspecified
0.000 0.827 0.173
E85.1 Neuropathic heredofamilial amyloidosis
0.000 0.827 0.173
E85.0 Nonneuropathic heredofamilial amyloidosis
0.000 0.827 0.173
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.833 0.167
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.166 0.834 0.000
M06.37 Rheumatoid nodule (Ankle and foot)
0.163 0.837 0.000
L43.9 Lichen planus, unspecified
0.000 0.838 0.162
M06.39 Rheumatoid nodule (Site unspecified)
0.161 0.839 0.000
M06.38 Rheumatoid nodule (Other)
0.161 0.839 0.000
M06.36 Rheumatoid nodule (Lower leg)
0.161 0.839 0.000
M06.35 Rheumatoid nodule (Pelvic region and thigh)
0.161 0.839 0.000
M06.33 Rheumatoid nodule (Forearm)
0.161 0.839 0.000
M06.31 Rheumatoid nodule (Shoulder region)
0.161 0.839 0.000
M06.30 Rheumatoid nodule (Multiple sites)
0.161 0.839 0.000
E20-E35 Disorders of other endocrine glands
0.001 0.840 0.159
E04.8 Other specified non-toxic goitre
0.001 0.841 0.159
E04.0 Non-toxic diffuse goitre
0.000 0.842 0.157
E88.2 Lipomatosis, not elsewhere classified
0.000 0.846 0.154
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.848 0.152
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.852 0.148
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.852 0.148
E70.3 Albinism
0.000 0.852 0.148
E70.2 Disorders of tyrosine metabolism
0.000 0.852 0.148
E70.1 Other hyperphenylalaninaemias
0.000 0.852 0.148
E70.0 Classical phenylketonuria
0.000 0.852 0.148
E71.3 Disorders of fatty-acid metabolism
0.000 0.852 0.148
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.852 0.148
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.852 0.148
E71.0 Maple-syrup-urine disease
0.000 0.852 0.148
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.852 0.148
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.852 0.148
E72.5 Disorders of glycine metabolism
0.000 0.852 0.148
E72.4 Disorders of ornithine metabolism
0.000 0.852 0.148
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.852 0.148
E72.2 Disorders of urea cycle metabolism
0.000 0.852 0.148
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.000 0.852 0.148
E72.0 Disorders of amino-acid transport
0.000 0.852 0.148
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.852 0.148
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.852 0.148
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.852 0.148
E76.2 Other mucopolysaccharidoses
0.000 0.852 0.148
E76.1 Mucopolysaccharidosis, type II
0.000 0.852 0.148
E76.0 Mucopolysaccharidosis, type I
0.000 0.852 0.148
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.852 0.148
E77.8 Other disorders of glycoprotein metabolism
0.000 0.852 0.148
E77.1 Defects in glycoprotein degradation
0.000 0.852 0.148
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.852 0.148
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.852 0.148
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.852 0.148
E79.1 Lesch-Nyhan syndrome
0.000 0.852 0.148
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.852 0.148
E84.9 Cystic fibrosis, unspecified
0.000 0.852 0.148
E84.8 Cystic fibrosis with other manifestations
0.000 0.852 0.148
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.852 0.148
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.852 0.148
E53.8 Deficiency of other specified B group vitamins
0.000 0.854 0.146
M06.32 Rheumatoid nodule (Upper arm)
0.145 0.855 0.000
E88.9 Metabolic disorder, unspecified
0.000 0.856 0.144
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.858 0.142
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.858 0.142
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.858 0.142
E74.2 Disorders of galactose metabolism
0.000 0.858 0.142
E74.1 Disorders of fructose metabolism
0.000 0.858 0.142
E74.0 Glycogen storage disease
0.000 0.858 0.142
E04.9 Non-toxic goitre, unspecified
0.000 0.859 0.141
E75.6 Lipid storage disorder, unspecified
0.000 0.860 0.140
E75.4 Neuronal ceroid lipofuscinosis
0.000 0.860 0.140
E75.3 Sphingolipidosis, unspecified
0.000 0.860 0.140
E75.2 Other sphingolipidosis
0.000 0.860 0.140
E75.1 Other gangliosidosis
0.000 0.860 0.140
E75.0 GM2 gangliosidosis
0.000 0.860 0.140
M06.40 Inflammatory polyarthropathy (Multiple sites)
0.138 0.862 0.000
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.863 0.136
E88.8 Other specified metabolic disorders
0.000 0.865 0.134
E88.3 Tumour lysis syndrome
0.000 0.866 0.134
E89.2 Postprocedural hypoparathyroidism
0.000 0.866 0.134
M06.19 Adult-onset Still's disease (Site unspecified)
0.134 0.866 0.000
M06.18 Adult-onset Still's disease (Other)
0.134 0.866 0.000
M06.17 Adult-onset Still's disease (Ankle and foot)
0.134 0.866 0.000
M06.16 Adult-onset Still's disease (Lower leg)
0.134 0.866 0.000
M06.15 Adult-onset Still's disease (Pelvic region and thigh)
0.134 0.866 0.000
M06.14 Adult-onset Still's disease (Hand)
0.134 0.866 0.000
M06.13 Adult-onset Still's disease (Forearm)
0.134 0.866 0.000
M06.12 Adult-onset Still's disease (Upper arm)
0.134 0.866 0.000
M06.11 Adult-onset Still's disease (Shoulder region)
0.134 0.866 0.000
M06.10 Adult-onset Still's disease (Multiple sites)
0.134 0.866 0.000
M06.29 Rheumatoid bursitis (Site unspecified)
0.134 0.866 0.000
M06.28 Rheumatoid bursitis (Other)
0.134 0.866 0.000
M06.27 Rheumatoid bursitis (Ankle and foot)
0.134 0.866 0.000
M06.26 Rheumatoid bursitis (Lower leg)
0.134 0.866 0.000
M06.25 Rheumatoid bursitis (Pelvic region and thigh)
0.134 0.866 0.000
M06.24 Rheumatoid bursitis (Hand)
0.134 0.866 0.000
M06.23 Rheumatoid bursitis (Forearm)
0.134 0.866 0.000
M06.22 Rheumatoid bursitis (Upper arm)
0.134 0.866 0.000
M06.21 Rheumatoid bursitis (Shoulder region)
0.134 0.866 0.000
M06.20 Rheumatoid bursitis (Multiple sites)
0.134 0.866 0.000
M06.89 Other specified rheumatoid arthritis (Site unspecified)
0.134 0.866 0.000
M06.88 Other specified rheumatoid arthritis (Other)
0.134 0.866 0.000
M06.87 Other specified rheumatoid arthritis (Ankle and foot)
0.134 0.866 0.000
M06.86 Other specified rheumatoid arthritis (Lower leg)
0.134 0.866 0.000
M06.85 Other specified rheumatoid arthritis (Pelvic region and thigh)
0.134 0.866 0.000
M06.84 Other specified rheumatoid arthritis (Hand)
0.134 0.866 0.000
M06.83 Other specified rheumatoid arthritis (Forearm)
0.134 0.866 0.000
M06.82 Other specified rheumatoid arthritis (Upper arm)
0.134 0.866 0.000
M06.81 Other specified rheumatoid arthritis (Shoulder region)
0.134 0.866 0.000
M06.80 Other specified rheumatoid arthritis (Multiple sites)
0.134 0.866 0.000
E74.3 Other disorders of intestinal carbohydrate absorption
0.000 0.867 0.133
E73.8 Other lactose intolerance
0.000 0.868 0.132
E73.1 Secondary lactase deficiency
0.000 0.868 0.132
E73.0 Congenital lactase deficiency
0.000 0.868 0.132
E75.5 Other lipid storage disorders
0.000 0.871 0.128
M06.48 Inflammatory polyarthropathy (Other)
0.127 0.872 0.000
M06.47 Inflammatory polyarthropathy (Ankle and foot)
0.127 0.872 0.000
M06.46 Inflammatory polyarthropathy (Lower leg)
0.127 0.872 0.000
M06.45 Inflammatory polyarthropathy (Pelvic region and thigh)
0.127 0.872 0.000
M06.44 Inflammatory polyarthropathy (Hand)
0.127 0.872 0.000
M06.43 Inflammatory polyarthropathy (Forearm)
0.127 0.872 0.000
M06.42 Inflammatory polyarthropathy (Upper arm)
0.127 0.872 0.000
M06.41 Inflammatory polyarthropathy (Shoulder region)
0.127 0.872 0.000
E22 Hyperfunction of pituitary gland
0.000 0.878 0.122
E83.4 Disorders of magnesium metabolism
0.000 0.879 0.121
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.880 0.120
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.880 0.120
E89.5 Postprocedural testicular hypofunction
0.000 0.880 0.120
E89.1 Postprocedural hypoinsulinaemia
0.000 0.880 0.120
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.884 0.116
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.885 0.115
E35 Disorders of endocrine glands in diseases classified elsewhere
0.001 0.885 0.114
E32 Diseases of thymus
0.001 0.885 0.114
E31 Polyglandular dysfunction
0.001 0.885 0.114
E30 Disorders of puberty, not elsewhere classified
0.001 0.885 0.114
E25 Adrenogenital disorders
0.001 0.885 0.114
E20 Hypoparathyroidism
0.000 0.888 0.112
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.889 0.110
M45-M49 Spondylopathies
0.110 0.889 0.000
E89.4 Postprocedural ovarian failure
0.000 0.890 0.110
E89.0 Postprocedural hypothyroidism
0.000 0.890 0.110
E73.9 Lactose intolerance, unspecified
0.000 0.890 0.110
E22.1 Hyperprolactinaemia
0.000 0.897 0.103
M06.49 Inflammatory polyarthropathy (Site unspecified)
0.103 0.897 0.000
E34 Other endocrine disorders
0.001 0.898 0.102
E27 Other disorders of adrenal gland
0.000 0.898 0.102
E29 Testicular dysfunction
0.000 0.902 0.097
E26 Hyperaldosteronism
0.001 0.902 0.097
E24 Cushing's syndrome
0.001 0.903 0.097
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.904 0.096
E22.0 Acromegaly and pituitary gigantism
0.000 0.904 0.096
E83.3 Disorders of phosphorus metabolism
0.000 0.905 0.095
E21.0 Primary hyperparathyroidism
0.000 0.905 0.095
E89.3 Postprocedural hypopituitarism
0.000 0.910 0.090
E23 Hypofunction and other disorders of pituitary gland
0.001 0.910 0.089
E27.1 Primary adrenocortical insufficiency
0.000 0.911 0.089
E07.9 Disorder of thyroid, unspecified
0.002 0.911 0.086
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.912 0.087
E22.8 Other hyperfunction of pituitary gland
0.000 0.912 0.087
E21.4 Other specified disorders of parathyroid gland
0.000 0.917 0.083
E21.2 Other hyperparathyroidism
0.000 0.917 0.083
E25.9 Adrenogenital disorder, unspecified
0.001 0.918 0.082
E25.8 Other adrenogenital disorders
0.001 0.918 0.082
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.001 0.918 0.082
E30.9 Disorder of puberty, unspecified
0.001 0.918 0.082
E30.8 Other disorders of puberty
0.001 0.918 0.082
E30.1 Precocious puberty
0.001 0.918 0.082
E30.0 Delayed puberty
0.001 0.918 0.082
E31.9 Polyglandular dysfunction, unspecified
0.001 0.918 0.082
E31.8 Other polyglandular dysfunction
0.001 0.918 0.082
E31.1 Polyglandular hyperfunction
0.001 0.918 0.082
E31.0 Autoimmune polyglandular failure
0.001 0.918 0.082
E32.9 Disease of thymus, unspecified
0.001 0.918 0.082
E32.8 Other diseases of thymus
0.001 0.918 0.082
E32.1 Abscess of thymus
0.001 0.918 0.082
E32.0 Persistent hyperplasia of thymus
0.001 0.918 0.082
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.001 0.918 0.082
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.001 0.918 0.082
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.001 0.918 0.082
E34.0 Carcinoid syndrome
0.000 0.918 0.082
E20.8 Other hypoparathyroidism
0.000 0.919 0.080
E20.1 Pseudohypoparathyroidism
0.000 0.919 0.080
E20.0 Idiopathic hypoparathyroidism
0.000 0.919 0.080
E80.7 Disorder of bilirubin metabolism, unspecified
0.000 0.920 0.079
E80.5 Crigler-Najjar syndrome
0.000 0.920 0.079
E80.3 Defects of catalase and peroxydase
0.000 0.920 0.079
E80.1 Porphyria cutanea tarda
0.000 0.920 0.079
E80.0 Hereditary erythropoietic porphyria
0.000 0.920 0.079
M46 Other inflammatory spondylopathies
0.079 0.921 0.000
E20.9 Hypoparathyroidism, unspecified
0.000 0.922 0.078
E23.6 Other disorders of pituitary gland
0.000 0.925 0.074

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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