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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2239526
log Bayes Factor = 78.9648
Chromosome 6   position 31,509,432  (GRCh37) Explore rs2239526 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E10.9 Without complications
0.000 0.000 1.000
K90.0 Coeliac disease
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
G35 Multiple sclerosis
1.000 0.000 0.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.000 1.000
E14 Unspecified diabetes mellitus
0.000 0.000 1.000
I20-I25 Ischaemic heart diseases
0.000 0.000 1.000
E11.9 Without complications
0.000 0.000 1.000
I25 Chronic ischaemic heart disease
0.000 0.000 1.000
E11 Non-insulin-dependent diabetes mellitus
0.000 0.000 1.000
L40 Psoriasis
0.000 0.000 1.000
L40.9 Psoriasis, unspecified
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
I10 Essential (primary) hypertension
0.000 0.001 0.999
I10-I15 Hypertensive diseases
0.000 0.001 0.999
Chapter IX Diseases of the circulatory system
0.000 0.001 0.999
L40-L45 Papulosquamous disorders
0.000 0.001 0.999
# Top node
0.000 0.001 0.999
I25.1 Atherosclerotic heart disease
0.000 0.001 0.999
J45.9 Asthma, unspecified
0.000 0.001 0.999
E14.3 With ophthalmic complications
0.000 0.002 0.998
E14.9 Without complications
0.000 0.004 0.996
K90 Intestinal malabsorption
0.000 0.005 0.995
Chapter VIII Diseases of the ear and mastoid process
0.000 0.006 0.994
Chapter XI Diseases of the digestive system
0.000 0.006 0.994
Chapter XII Diseases of the skin and subcutaneous tissue
0.000 0.007 0.993
K90-K93 Other diseases of the digestive system
0.000 0.007 0.993
E10.1 With ketoacidosis
0.000 0.008 0.992
K70-K77 Diseases of liver
0.000 0.013 0.987
E10.4 With neurological complications
0.000 0.013 0.987
G35-G37 Demyelinating diseases of the central nervous system
0.985 0.015 0.000
H36.0 Diabetic retinopathy
0.000 0.015 0.985
L40.5 Arthropathic psoriasis
0.000 0.015 0.985
H36 Retinal disorders in diseases classified elsewhere
0.000 0.017 0.983
H30-H36 Disorders of choroid and retina
0.000 0.018 0.982
G37 Other demyelinating diseases of central nervous system
0.982 0.018 0.000
H65-H75 Diseases of middle ear and mastoid
0.000 0.019 0.981
I24 Other acute ischaemic heart diseases
0.000 0.021 0.979
E78.0 Pure hypercholesterolaemia
0.000 0.021 0.979
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.022 0.978
E70-E90 Metabolic disorders
0.000 0.024 0.975
G37.9 Demyelinating disease of central nervous system, unspecified
0.975 0.025 0.000
H35 Other retinal disorders
0.000 0.025 0.975
Chapter VII Diseases of the eye and adnexa
0.000 0.028 0.972
I25.8 Other forms of chronic ischaemic heart disease
0.000 0.030 0.970
K74 Fibrosis and cirrhosis of liver
0.000 0.032 0.968
H60-H62 Diseases of external ear
0.000 0.033 0.967
H35.8 Other specified retinal disorders
0.000 0.034 0.966
H66 Suppurative and unspecified otitis media
0.000 0.039 0.961
H66.3 Other chronic suppurative otitis media
0.000 0.043 0.957
H71 Cholesteatoma of middle ear
0.000 0.043 0.957
I22 Subsequent myocardial infarction
0.000 0.043 0.957
L43 Lichen planus
0.000 0.044 0.956
I24.8 Other forms of acute ischaemic heart disease
0.000 0.047 0.953
I25.5 Ischaemic cardiomyopathy
0.000 0.055 0.945
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.060 0.940
K50-K52 Noninfective enteritis and colitis
0.000 0.066 0.934
K52 Other non-infective gastro-enteritis and colitis
0.000 0.070 0.930
K52.9 Non-infective gastro-enteritis and colitis, unspecified
0.000 0.074 0.926
I20 Angina pectoris
0.000 0.079 0.921
E13 Other specified diabetes mellitus
0.000 0.082 0.917
I22.9 Subsequent myocardial infarction of unspecified site
0.000 0.087 0.913
K74.6 Other and unspecified cirrhosis of liver
0.000 0.088 0.912
I20.9 Angina pectoris, unspecified
0.000 0.090 0.910
K75 Other inflammatory liver diseases
0.000 0.095 0.905
E78.8 Other disorders of lipoprotein metabolism
0.000 0.097 0.903
L43.9 Lichen planus, unspecified
0.000 0.102 0.898
E16 Other disorders of pancreatic internal secretion
0.000 0.102 0.898
H60 Otitis externa
0.000 0.104 0.896
H61 Other disorders of external ear
0.000 0.108 0.892
I25.0 Atherosclerotic cardiovascular disease, so described
0.000 0.112 0.888
E10.8 With unspecified complications
0.000 0.112 0.888
E10.5 With peripheral circulatory complications
0.000 0.115 0.885
K74.5 Biliary cirrhosis, unspecified
0.000 0.127 0.873
G37.8 Other specified demyelinating diseases of central nervous system
0.870 0.130 0.000
J45 Asthma
0.000 0.130 0.870
E10.2 With renal complications
0.000 0.134 0.866
I25.2 Old myocardial infarction
0.000 0.138 0.862
E10.0 With coma
0.000 0.139 0.861
E13.9 Without complications
0.000 0.142 0.858
E16.2 Hypoglycaemia, unspecified
0.000 0.144 0.856
E78.2 Mixed hyperlipidaemia
0.000 0.146 0.854
L50-L54 Urticaria and erythema
0.000 0.149 0.851
I11 Hypertensive heart disease
0.000 0.150 0.850
E00-E07 Disorders of thyroid gland
0.000 0.151 0.849
E11.0 With coma
0.000 0.154 0.846
K75.4 Autoimmune hepatitis
0.000 0.155 0.845
H35.2 Other proliferative retinopathy
0.000 0.162 0.838
I22.1 Subsequent myocardial infarction of inferior wall
0.000 0.164 0.836
I24.9 Acute ischaemic heart disease, unspecified
0.000 0.166 0.834
E11.6 With other specified complications
0.000 0.168 0.832
K76 Other diseases of liver
0.000 0.171 0.829
E11.3 With ophthalmic complications
0.000 0.172 0.828
E03 Other hypothyroidism
0.000 0.173 0.827
K73 Chronic hepatitis, not elsewhere classified
0.000 0.174 0.826
J40-J47 Chronic lower respiratory diseases
0.000 0.175 0.825
K52.8 Other specified non-infective gastro-enteritis and colitis
0.000 0.180 0.820
Chapter X Diseases of the respiratory system
0.000 0.183 0.817
E03.9 Hypothyroidism, unspecified
0.000 0.183 0.817
K52.1 Toxic gastro-enteritis and colitis
0.000 0.186 0.814
H35.5 Hereditary retinal dystrophy
0.000 0.188 0.812
L43.8 Other lichen planus
0.000 0.190 0.810
E83.1 Disorders of iron metabolism
0.808 0.192 0.000
H53-H54 Visual disturbances and blindness
0.000 0.194 0.806
E11.1 With ketoacidosis
0.000 0.196 0.804
I15 Secondary hypertension
0.000 0.199 0.801
H74 Other disorders of middle ear and mastoid
0.000 0.200 0.800
L40.8 Other psoriasis
0.000 0.204 0.796
E78.6 Lipoprotein deficiency
0.000 0.205 0.795
E14.6 With other specified complications
0.000 0.208 0.792
L40.1 Generalised pustular psoriasis
0.000 0.208 0.792
E14.8 With unspecified complications
0.000 0.212 0.788
K75.8 Other specified inflammatory liver diseases
0.000 0.214 0.786
K76.9 Liver disease, unspecified
0.000 0.217 0.783
E10.6 With other specified complications
0.000 0.217 0.783
L42 Pityriasis rosea
0.000 0.218 0.782
E74 Other disorders of carbohydrate metabolism
0.000 0.218 0.781
H61.1 Non-infective disorders of pinna
0.000 0.219 0.781
H61.3 Acquired stenosis of external ear canal
0.000 0.220 0.780
K74.3 Primary biliary cirrhosis
0.000 0.221 0.779
H35.0 Background retinopathy and retinal vascular changes
0.000 0.224 0.776
H60.3 Other infective otitis externa
0.000 0.230 0.770
J43 Emphysema
0.000 0.231 0.769
H46-H48 Disorders of optic nerve and visual pathways
0.000 0.234 0.766
I11.9 Hypertensive heart disease without (congestive) heart failure
0.000 0.234 0.766
H35.7 Separation of retinal layers
0.000 0.239 0.761
I23 Certain current complications following acute myocardial infarction
0.000 0.242 0.758
I24.0 Coronary thrombosis not resulting in myocardial infarction
0.000 0.247 0.753
E14.1 With ketoacidosis
0.000 0.248 0.751
E11.2 With renal complications
0.000 0.250 0.750
H90-H95 Other disorders of ear
0.000 0.251 0.749
K90.8 Other intestinal malabsorption
0.000 0.257 0.743
L40.3 Pustulosis palmaris et plantaris
0.000 0.261 0.739
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.737 0.263 0.000
E85 Amyloidosis
0.000 0.268 0.732
H66.1 Chronic tubotympanic suppurative otitis media
0.000 0.268 0.732
E16.1 Other hypoglycaemia
0.000 0.274 0.726
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.276 0.724
H61.9 Disorder of external ear, unspecified
0.000 0.276 0.724
H31 Other disorders of choroid
0.000 0.276 0.724
K73.9 Chronic hepatitis, unspecified
0.000 0.278 0.722
L10-L14 Bullous disorders
0.000 0.278 0.722
E14.4 With neurological complications
0.000 0.278 0.721
I25.3 Aneurysm of heart
0.000 0.279 0.720
K72 Hepatic failure, not elsewhere classified
0.000 0.281 0.719
H61.2 Impacted cerumen
0.000 0.281 0.719
E10.7 With multiple complications
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
E14.7 With multiple complications
0.000 0.283 0.717
E14.2 Withrenal complications
0.000 0.283 0.717
E14.0 With coma
0.000 0.283 0.717
I25.6 Silent myocardial ischaemia
0.000 0.283 0.717
E11.7 With multiple complications
0.000 0.283 0.717
L40.4 Guttate psoriasis
0.000 0.283 0.717
L40.2 Acrodermatitis continua
0.000 0.283 0.717
I13 Hypertensive heart and renal disease
0.000 0.284 0.716
I00-I02 Acute rheumatic fever
0.000 0.284 0.716
H66.4 Suppurative otitis media, unspecified
0.000 0.284 0.716
L44 Other papulosquamous disorders
0.000 0.284 0.716
L41 Parapsoriasis
0.000 0.284 0.716
L45 Papulosquamous disorders in diseases classified elsewhere
0.000 0.284 0.716
Chapter XVI Certain conditions originating in the perinatal period
0.000 0.284 0.716
H35.6 Retinal haemorrhage
0.000 0.285 0.715
H43-H45 Disorders of vitreous body and globe
0.000 0.286 0.714
K90.3 Pancreatic steatorrhoea
0.000 0.286 0.714
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.286 0.714
K90.1 Tropical sprue
0.000 0.286 0.714
G36 Other acute disseminated demyelination
0.713 0.286 0.000
K93 Disorders of other digestive organs in diseases classified elsewhere
0.000 0.288 0.712
H70 Mastoiditis and related conditions
0.000 0.289 0.711
L52 Erythema nodosum
0.000 0.289 0.711
H74.4 Polyp of middle ear
0.000 0.290 0.710
H60.9 Otitis externa, unspecified
0.000 0.290 0.710
E14.5 With peripheral circulatory complications
0.000 0.291 0.709
J43.9 Emphysema, unspecified
0.000 0.292 0.708
K77 Liver disorders in diseases classified elsewhere
0.000 0.292 0.708
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.294 0.706
I20.0 Unstable angina
0.000 0.295 0.705
H36.8 Other retinal disorders in diseases classified elsewhere
0.000 0.295 0.705
K71 Toxic liver disease
0.000 0.295 0.704
H32 Chorioretinal disorders in diseases classified elsewhere
0.000 0.296 0.704
G37.5 Concentric sclerosis [Balo]
0.704 0.296 0.000
G37.4 Subacute necrotising myelitis
0.704 0.296 0.000
G37.2 Central pontine myelinolysis
0.704 0.296 0.000
G37.1 Central demyelination of corpus callosum
0.704 0.296 0.000
G37.0 Diffuse sclerosis
0.704 0.296 0.000
H75 Other disorders of middle ear and mastoid in diseases classified elsewhere
0.000 0.296 0.703
H68 Eustachian salpingitis and obstruction
0.000 0.296 0.703
H67 Otitis media in diseases classified elsewhere
0.000 0.296 0.703
H54 Blindness and low vision
0.000 0.297 0.703
E79 Disorders of purine and pyrimidine metabolism
0.000 0.297 0.703
H34 Retinal vascular occlusions
0.000 0.297 0.703
H60.5 Acute otitis externa, non-infective
0.000 0.298 0.702
E78.3 Hyperchylomicronaemia
0.000 0.298 0.701
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.299 0.701
E88 Other metabolic disorders
0.000 0.299 0.701
I25.4 Coronary artery aneurysm
0.000 0.300 0.700
E77 Disorders of glycoprotein metabolism
0.000 0.300 0.699
E76 Disorders of glycosaminoglycan metabolism
0.000 0.300 0.699
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.300 0.699
E70 Disorders of aromatic amino-acid metabolism
0.000 0.300 0.699
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.300 0.699
H35.1 Retinopathy of prematurity
0.000 0.301 0.699
K74.4 Secondary biliary cirrhosis
0.000 0.306 0.694
K74.2 Hepatic fibrosis with hepatic sclerosis
0.000 0.306 0.694
K74.1 Hepatic sclerosis
0.000 0.306 0.694
H90 Conductive and sensorineural hearing loss
0.000 0.306 0.694
H62 Disorders of external ear in diseases classified elsewhere
0.000 0.307 0.693
K80-K87 Disorders of gallbladder, biliary tract and pancreas
0.000 0.308 0.692
E83 Disorders of mineral metabolism
0.668 0.308 0.024
K60.2 Anal fissure, unspecified
0.000 0.309 0.691
H35.4 Peripheral retinal degeneration
0.000 0.310 0.690
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.313 0.687
L43.3 Subacute (active) lichen planus
0.000 0.315 0.685
L43.2 Lichenoid drug reaction
0.000 0.315 0.685
L43.1 Bullous lichen planus
0.000 0.315 0.685
L43.0 Hypertrophic lichen planus
0.000 0.315 0.685
K55-K64 Other diseases of intestines
0.000 0.315 0.685
K60 Fissure and fistula of anal and rectal regions
0.000 0.315 0.685
H47 Other disorders of optic [2nd] nerve and visual pathways
0.000 0.318 0.682
J85-J86 Suppurative and necrotic conditions of lower respiratory tract
0.000 0.318 0.682
H54.9 Unspecified visual impairment (binocular)
0.000 0.319 0.681
H66.0 Acute suppurative otitis media
0.000 0.319 0.681
H60.4 Cholesteatoma of external ear
0.000 0.319 0.681
K74.0 Hepatic fibrosis
0.000 0.321 0.679
H30 Chorioretinal inflammation
0.000 0.323 0.677
J46 Status asthmaticus
0.000 0.324 0.676
E15 Nondiabetic hypoglycaemic coma
0.000 0.326 0.674
E11.4 With neurological complications
0.000 0.326 0.674
H60.8 Other otitis externa
0.000 0.327 0.673
E72 Other disorders of amino-acid metabolism
0.000 0.333 0.666
L51 Erythema multiforme
0.000 0.333 0.667
J42 Unspecified chronic bronchitis
0.000 0.334 0.666
K76.8 Other specified diseases of liver
0.000 0.338 0.662
H74.9 Disorder of middle ear and mastoid, unspecified
0.000 0.341 0.659
H90.5 Sensorineural hearing loss, unspecified
0.000 0.341 0.659
H72 Perforation of tympanic membrane
0.000 0.341 0.659
E13.8 With unspecified complications
0.000 0.342 0.658
E13.7 With multiple complications
0.000 0.342 0.658
E13.6 With other specified complications
0.000 0.342 0.658
E13.5 With peripheral circulatory complications
0.000 0.342 0.658
E13.4 With neurological complications
0.000 0.342 0.658
E13.3 With ophthalmic complications
0.000 0.342 0.658
E13.2 With renal complications
0.000 0.342 0.658
E13.1 With ketoacidosis
0.000 0.342 0.658
E13.0 With coma
0.000 0.342 0.658
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.343 0.657
E84 Cystic fibrosis
0.000 0.344 0.655
L50 Urticaria
0.000 0.345 0.655
K90.9 Intestinal malabsorption, unspecified
0.000 0.347 0.653
K58 Irritable bowel syndrome
0.000 0.347 0.653
E78.1 Pure hyperglyceridaemia
0.000 0.347 0.653
E83.3 Disorders of phosphorus metabolism
0.646 0.350 0.004
I22.0 Subsequent myocardial infarction of anterior wall
0.000 0.350 0.650
K75.2 Nonspecific reactive hepatitis
0.000 0.351 0.648
K75.1 Phlebitis of portal vein
0.000 0.351 0.648
H60.1 Cellulitis of external ear
0.000 0.353 0.647
H60.0 Abscess of external ear
0.000 0.353 0.647
K83 Other diseases of biliary tract
0.000 0.356 0.644
H74.8 Other specified disorders of middle ear and mastoid
0.000 0.356 0.644
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.356 0.644
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.356 0.644
E16.4 Abnormal secretion of gastrin
0.000 0.356 0.644
E16.3 Increased secretion of glucagon
0.000 0.356 0.644
E78.5 Hyperlipidaemia, unspecified
0.000 0.357 0.643
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.357 0.643
E74.3 Other disorders of intestinal carbohydrate absorption
0.000 0.357 0.643
H60.2 Malignant otitis externa
0.000 0.358 0.642
L40.0 Psoriasis vulgaris
0.000 0.359 0.641
J60-J70 Lung diseases due to external agents
0.000 0.361 0.639
K83.0 Cholangitis
0.000 0.362 0.638
I12 Hypertensive renal disease
0.000 0.364 0.635
H35.9 Retinal disorder, unspecified
0.000 0.368 0.632
H73 Other disorders of tympanic membrane
0.000 0.369 0.631
I15.1 Hypertension secondary to other renal disorders
0.000 0.371 0.629
E40-E46 Malnutrition
0.000 0.371 0.629
K58.0 Irritable bowel syndrome with diarrhoea
0.000 0.372 0.628
K76.0 Fatty (change of) liver, not elsewhere classified
0.000 0.372 0.628
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.373 0.627
E78.4 Other hyperlipidaemia
0.000 0.375 0.625
J45.1 Nonallergic asthma
0.000 0.376 0.624
K86 Other diseases of pancreas
0.000 0.376 0.624
H47.3 Other disorders of optic disk
0.000 0.380 0.620
H43 Disorders of vitreous body
0.000 0.384 0.616
I24.1 Dressler's syndrome
0.000 0.384 0.616
E11.5 With peripheral circulatory complications
0.000 0.386 0.614
J43.2 Centrilobular emphysema
0.000 0.387 0.613
E88.2 Lipomatosis, not elsewhere classified
0.000 0.388 0.612
L54 Erythema in diseases classified elsewhere
0.000 0.390 0.610
E89.3 Postprocedural hypopituitarism
0.000 0.390 0.610
H55-H59 Other disorders of eye and adnexa
0.000 0.390 0.610
K73.2 Chronic active hepatitis, not elsewhere classified
0.000 0.391 0.608
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.391 0.608
E00 Congenital iodine-deficiency syndrome
0.000 0.391 0.608
K60.0 Acute anal fissure
0.000 0.392 0.608
M45.X9 Ankylosing spondylitis (Site unspecified)
0.000 0.399 0.601
L13 Other bullous disorders
0.000 0.402 0.598
H66.2 Chronic atticoantral suppurative otitis media
0.000 0.403 0.597
I15.9 Seconday hypertension, unspecified
0.000 0.403 0.597
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.405 0.595
K76.5 Hepatic veno-occlusive disease
0.000 0.406 0.594
K76.4 Peliosis hepatis
0.000 0.406 0.594
K76.3 Infarction of liver
0.000 0.406 0.594
K76.2 Central haemorrhagic necrosis of liver
0.000 0.406 0.594
I15.0 Renovascular hypertension
0.000 0.406 0.594
E03.5 Myxoedema coma
0.000 0.407 0.593
E03.4 Atrophy of thyroid (acquired)
0.000 0.407 0.593
E03.3 Postinfectious hypothyroidism
0.000 0.407 0.593
E03.1 Congenital hypothyroidism without goitre
0.000 0.407 0.593
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.407 0.593
E85.9 Amyloidosis, unspecified
0.000 0.407 0.593
K73.1 Chronic lobular hepatitis, not elsewhere classified
0.000 0.407 0.593
K73.0 Chronic persistent hepatitis, not elsewhere classified
0.000 0.407 0.593
H92 Otalgia and effusion of ear
0.000 0.411 0.589
H74.2 Discontinuity and dislocation of ear ossicles
0.000 0.412 0.588
K75.3 Granulomatous hepatitis, not elsewhere classified
0.000 0.412 0.588
H90.7 Mixed conductive and sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
0.000 0.415 0.585
K52.2 Allergic and dietetic gastro-enteritis and colitis
0.000 0.415 0.584
I23.8 Other current complications following acute myocardial infarction
0.000 0.416 0.584
H54.7 Unspecified visual loss
0.000 0.416 0.584
J90-J94 Other diseases of pleura
0.000 0.418 0.582
K86.1 Other chronic pancreatitis
0.000 0.419 0.581
E07 Other disorders of thyroid
0.000 0.421 0.579
I22.8 Subsequent myocardial infarction of other sites
0.000 0.425 0.575
I15.8 Other secondary hypertension
0.000 0.425 0.574
I15.2 Hypertension secondary to endocrine disorders
0.000 0.425 0.574
H90.2 Conductive hearing loss, unspecified
0.000 0.427 0.573
J69 Pneumonitis due to solids and liquids
0.000 0.428 0.572
K72.9 Hepatic failure, unspecified
0.000 0.428 0.572
E05.9 Thyrotoxicosis, unspecified
0.000 0.432 0.568
K75.9 Inflammatory liver disease, unspecified
0.000 0.432 0.568
J92 Pleural plaque
0.000 0.432 0.568
L53 Other erythematous conditions
0.000 0.433 0.567
J43.8 Other emphysema
0.000 0.433 0.567
K75.0 Abscess of liver
0.000 0.435 0.565
M45 Ankylosing spondylitis
0.000 0.436 0.564
E50-E64 Other nutritional deficiencies
0.000 0.436 0.564
J95-J99 Other diseases of the respiratory system
0.000 0.438 0.562
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.439 0.560
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.439 0.560
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.439 0.560
E74.2 Disorders of galactose metabolism
0.000 0.439 0.560
E74.1 Disorders of fructose metabolism
0.000 0.439 0.560
E74.0 Glycogen storage disease
0.000 0.439 0.560
H47.2 Optic atrophy
0.000 0.440 0.560
H34.8 Other retinal vascular occlusions
0.000 0.440 0.560
J92.9 Pleural plaque without asbestos
0.000 0.445 0.555
H31.0 Chorioretinal scars
0.000 0.445 0.555
H31.1 Choroidal degeneration
0.000 0.446 0.554
J41 Simple and mucopurulent chronic bronchitis
0.000 0.446 0.553
J45.8 Mixed asthma
0.000 0.448 0.552
J43.1 Panlobular emphysema
0.000 0.449 0.551
J43.0 MacLeod's syndrome
0.000 0.449 0.551
H48 Disorders of optic [2nd] nerve and visual pathways in diseases classified elsewhere
0.000 0.450 0.549
K86.2 Cyst of pancreas
0.000 0.450 0.550
K73.8 Other chronic hepatitis, not elsewhere classified
0.000 0.450 0.549
K60.5 Anorectal fistula
0.000 0.451 0.549
J85 Abscess of lung and mediastinum
0.000 0.451 0.549
H61.8 Other specified disorders of external ear
0.000 0.454 0.546
H72.2 Other marginal perforations of tympanic membrane
0.000 0.455 0.545
E75.5 Other lipid storage disorders
0.000 0.456 0.544
I11.0 Hypertensive heart disease with (congestive) heart failure
0.000 0.456 0.544
I23.6 Thrombosis of atrium, auricular appendage and ventricle as current complications following acute myocardial infarction
0.000 0.457 0.543
I23.5 Rupture of papillary muscle as current complication following acute myocardial infarction
0.000 0.457 0.543
I23.4 Rupture of chordae tendineae as current complication following acute myocardial infarction
0.000 0.457 0.543
I23.3 Rupture of cardiac wall without haemopericardium as current complication following acute myocardial infarction
0.000 0.457 0.543
I23.2 Ventricular septal defect as current complication following acute myocardial infarction
0.000 0.457 0.543
I23.1 Atrial septal defect as current complication following acute myocardial infarction
0.000 0.457 0.543
I23.0 Haemopericardium as current complication following acute myocardial infarction
0.000 0.457 0.543
E73 Lactose intolerance
0.001 0.457 0.543
J86 Pyothorax
0.000 0.459 0.541
H53 Visual disturbances
0.000 0.459 0.541
H94 Other disorders of ear in diseases classified elsewhere
0.000 0.463 0.537
E88.3 Tumour lysis syndrome
0.000 0.464 0.535
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.000 0.465 0.535
I12.9 Hypertensive renal disease without renal failure
0.000 0.465 0.535
H70.1 Chronic mastoiditis
0.000 0.466 0.534
K60.4 Rectal fistula
0.000 0.468 0.532
L55-L59 Radiation-related disorders of the skin and subcutaneous tissue
0.000 0.468 0.532
H72.0 Central perforation of tympanic membrane
0.000 0.468 0.532
H54.0 Blindness, both eyes
0.000 0.471 0.529
J69.0 Pneumonitis due to food and vomit
0.000 0.471 0.529
H10-H13 Disorders of conjunctiva
0.000 0.472 0.528
E85.3 Secondary systemic amyloidosis
0.000 0.473 0.527
H92.1 Otorrhoea
0.000 0.474 0.526
E85.8 Other amyloidosis
0.000 0.475 0.525
E85.2 Heredofamilial amyloidosis, unspecified
0.000 0.475 0.525
E85.1 Neuropathic heredofamilial amyloidosis
0.000 0.475 0.525
E85.0 Nonneuropathic heredofamilial amyloidosis
0.000 0.475 0.525
H72.8 Other perforations of tympanic membrane
0.000 0.476 0.524
E75.6 Lipid storage disorder, unspecified
0.000 0.481 0.519
E75.4 Neuronal ceroid lipofuscinosis
0.000 0.481 0.519
E75.3 Sphingolipidosis, unspecified
0.000 0.481 0.519
E75.2 Other sphingolipidosis
0.000 0.481 0.519
E75.1 Other gangliosidosis
0.000 0.481 0.519
E75.0 GM2 gangliosidosis
0.000 0.481 0.519
G36.0 Neuromyelitis optica [Devic]
0.519 0.481 0.000
H55 Nystagmus and other irregular eye movements
0.000 0.481 0.519
H31.9 Disorder of choroid, unspecified
0.000 0.481 0.519
H31.4 Choroidal detachment
0.000 0.481 0.519
H31.2 Hereditary choroidal dystrophy
0.000 0.481 0.519
L10 Pemphigus
0.000 0.482 0.518
L14 Bullous disorders in diseases classified elsewhere
0.000 0.482 0.518
L51.1 Bullous erythema multiforme
0.000 0.484 0.516
K72.1 Chronic hepatic failure
0.000 0.484 0.516
H43.9 Disorder of vitreous body, unspecified
0.000 0.486 0.514
H43.2 Crystalline deposits in vitreous body
0.000 0.486 0.514
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
K76.1 Chronic passive congestion of liver
0.000 0.486 0.514
I13.9 Hypertensive heart and renal disease, unspecified
0.000 0.486 0.514
I13.2 Hypertensive heart and renal disease with both (congestive) heart failure and renal failure
0.000 0.486 0.514
I13.1 Hypertensive heart and renal disease with renal failure
0.000 0.486 0.514
I13.0 Hypertensive heart and renal disease with (congestive) heart failure
0.000 0.486 0.514
I02 Rheumatic chorea
0.000 0.486 0.514
I01 Rheumatic fever with heart involvement
0.000 0.486 0.514
I00 Rheumatic fever without mention of heart involvement
0.000 0.486 0.514
L41.9 Parapsoriasis, unspecified
0.000 0.486 0.513
L41.8 Other parapsoriasis
0.000 0.486 0.513
L41.5 Retiform parapsoriasis
0.000 0.486 0.513
L41.4 Large plaque parapsoriasis
0.000 0.486 0.513
L41.3 Small plaque parapsoriasis
0.000 0.486 0.513
L41.2 Lymphomatoid papulosis
0.000 0.486 0.513
L41.1 Pityriasis lichenoides chronica
0.000 0.486 0.513
L41.0 Pityriasis lichenoides et varioliformis acuta
0.000 0.486 0.513
L44.9 Papulosquamous disorder, unspecified
0.000 0.486 0.513
L44.8 Other specified papulosquamous disorders
0.000 0.486 0.513
L44.4 Infantile papular acrodermatitis [Giannotti-Crosti]
0.000 0.486 0.513
L44.3 Lichen ruber moniliformis
0.000 0.486 0.513
L44.2 Lichen striatus
0.000 0.486 0.513
L44.1 Lichen nitidus
0.000 0.486 0.513
L44.0 Pityriasis rubra pilaris
0.000 0.486 0.513
P90-P96 Other disorders originating in the perinatal period
0.000 0.486 0.513
P80-P83 Conditions involving the integument and temperature regulation of fetus and newborn
0.000 0.486 0.513
P75-P78 Digestive system disorders of fetus and newborn
0.000 0.486 0.513
P70-P74 Transitory endocrine and metabolic disorders specific to fetus and newborn
0.000 0.486 0.513
P50-P61 Haemorrhagic and haematological disorders of fetus and newborn
0.000 0.486 0.513
P35-P39 Infections specific to the perinatal period
0.000 0.486 0.513
P20-P29 Respiratory and cardiovascular disorders specific to the perinatal period
0.000 0.486 0.513
P10-P15 Birth trauma
0.000 0.486 0.513
P05-P08 Disorders related to length of gestation and fetal growth
0.000 0.486 0.513
P00-P04 Fetus and newborn affected by maternal factors and by complications of pregnancy, labour and delivery
0.000 0.486 0.513
H31.3 Choroidal haemorrhage and rupture
0.000 0.487 0.513
H45 Disorders of vitreous body and globe in diseases classified elsewhere
0.000 0.488 0.512
G36.9 Acute disseminated demyelination, unspecified
0.512 0.488 0.000
G36.8 Other specified acute disseminated demyelination
0.512 0.488 0.000
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.512 0.488 0.000
K52.3 Indeterminate colitis
0.000 0.489 0.511
K93.8 Disorders of other specified digestive organs in diseases classified elsewhere
0.000 0.490 0.510
K93.1 Megacolon in Chagas' disease
0.000 0.490 0.510
K93.0 Tuberculous disorders of intestines, peritoneum and mesenteric glands
0.000 0.490 0.510
H73.9 Disorder of tympanic membrane, unspecified
0.000 0.490 0.510
H70.8 Other mastoiditis and related conditions
0.000 0.490 0.510
H70.2 Petrositis
0.000 0.490 0.510
H70.0 Acute mastoiditis
0.000 0.490 0.510
L13.0 Dermatitis herpetiformis
0.000 0.490 0.510
L72.1 Trichilemmal cyst
0.509 0.491 0.000
H90.3 Sensorineural hearing loss, bilateral
0.000 0.491 0.508
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.492 0.508
K77.8 Liver disorders in other diseases classified elsewhere
0.000 0.492 0.507
K77.0 Liver disorders in infectious and parasitic diseases classified elsewhere
0.000 0.492 0.507
H34.9 Retinal vascular occlusion, unspecified
0.000 0.493 0.507
E88.8 Other specified metabolic disorders
0.000 0.493 0.506
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.494 0.506
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.494 0.506
E89.5 Postprocedural testicular hypofunction
0.000 0.494 0.506
E89.1 Postprocedural hypoinsulinaemia
0.000 0.494 0.506
K71.9 Toxic liver disease, unspecified
0.000 0.495 0.505
K71.8 Toxic liver disease with other disorders of liver
0.000 0.495 0.505
K71.7 Toxic liver disease with fibrosis and cirrhosis of liver
0.000 0.495 0.505
K71.6 Toxic liver disease with hepatitis, not elsewhere classified
0.000 0.495 0.505
K71.5 Toxic liver disease with chronic active hepatitis
0.000 0.495 0.505
K71.4 Toxic liver disease with chronic lobular hepatitis
0.000 0.495 0.505
K71.3 Toxic liver disease with chronic persistent hepatitis
0.000 0.495 0.505
K71.2 Toxic liver disease with acute hepatitis
0.000 0.495 0.505
K71.0 Toxic liver disease with cholestasis
0.000 0.495 0.505
H32.8 Other chorioretinal disorders in diseases classified elsewhere
0.000 0.495 0.505
H32.0 Chorioretinal inflammation in infectious and parasitic diseases classified elsewhere
0.000 0.495 0.505
H67.8 Otitis media in other diseases classified elsewhere
0.000 0.495 0.504
H67.1 Otitis media in viral diseases classified elsewhere
0.000 0.495 0.504
H67.0 Otitis media in bacterial diseases classified elsewhere
0.000 0.495 0.504
H68.1 Obstruction of Eustachian tube
0.000 0.495 0.504
H68.0 Eustachian salpingitis
0.000 0.495 0.504
H75.8 Other specified disorders of middle ear and mastoid in diseases classified elsewhere
0.000 0.495 0.504
H75.0 Mastoiditis in infectious and parasitic diseases classified elsewhere
0.000 0.495 0.504
H54.3 Unqualified visual loss, both eyes
0.000 0.496 0.504
H54.2 Low vision, both eyes
0.000 0.496 0.504
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.496 0.504
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.496 0.504
E79.1 Lesch-Nyhan syndrome
0.000 0.496 0.504
H34.0 Transient retinal artery occlusion
0.000 0.496 0.504

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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