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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2239705
log Bayes Factor = 9.17316
Chromosome 6   position 31,513,402  (GRCh37) Explore rs2239705 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
E03 Other hypothyroidism
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
E10.9 Without complications
0.000 0.001 0.999
E10-E14 Diabetes mellitus
0.000 0.001 0.999
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.009 0.991
E70-E90 Metabolic disorders
0.000 0.022 0.978
E86 Volume depletion
0.000 0.029 0.971
E06 Thyroiditis
0.000 0.036 0.964
E10.3 With ophthalmic complications
0.000 0.038 0.962
E05.9 Thyrotoxicosis, unspecified
0.000 0.043 0.957
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.045 0.955
E06.3 Autoimmune thyroiditis
0.000 0.071 0.929
E10.1 With ketoacidosis
0.000 0.083 0.917
E40-E46 Malnutrition
0.000 0.147 0.853
E73 Lactose intolerance
0.000 0.156 0.844
E87 Other disorders of fluid, electrolyte and acid-base balance
0.000 0.167 0.833
E20-E35 Disorders of other endocrine glands
0.000 0.173 0.827
E88 Other metabolic disorders
0.000 0.176 0.824
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.182 0.818
E10.4 With neurological complications
0.000 0.192 0.808
E27 Other disorders of adrenal gland
0.000 0.192 0.808
E10.2 With renal complications
0.000 0.195 0.805
E27.1 Primary adrenocortical insufficiency
0.000 0.206 0.794
E10.0 With coma
0.000 0.208 0.792
E03.8 Other specified hypothyroidism
0.000 0.211 0.789
E06.9 Thyroiditis, unspecified
0.000 0.241 0.759
E73.9 Lactose intolerance, unspecified
0.000 0.251 0.749
E46 Unspecified protein-energy malnutrition
0.000 0.252 0.748
E87.2 Acidosis
0.000 0.264 0.736
E87.7 Fluid overload
0.000 0.266 0.734
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.271 0.729
E80.4 Gilbert's syndrome
0.000 0.280 0.720
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.280 0.720
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.283 0.717
E03.5 Myxoedema coma
0.000 0.283 0.717
E03.4 Atrophy of thyroid (acquired)
0.000 0.283 0.717
E03.3 Postinfectious hypothyroidism
0.000 0.283 0.717
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.283 0.717
E10.7 With multiple complications
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.284 0.716
E05.5 Thyroid crisis or storm
0.000 0.290 0.710
E05.4 Thyrotoxicosis factitia
0.000 0.290 0.710
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.290 0.710
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.290 0.710
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.294 0.706
E84 Cystic fibrosis
0.000 0.299 0.701
E77 Disorders of glycoprotein metabolism
0.000 0.299 0.701
E76 Disorders of glycosaminoglycan metabolism
0.000 0.299 0.701
E72 Other disorders of amino-acid metabolism
0.000 0.299 0.701
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.299 0.701
E70 Disorders of aromatic amino-acid metabolism
0.000 0.299 0.701
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.299 0.701
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.305 0.695
E79 Disorders of purine and pyrimidine metabolism
0.000 0.307 0.693
E87.8 Other disorders of electrolyte and fluid balance, not elsewhere classified
0.000 0.309 0.691
E06.5 Other chronic thyroiditis
0.000 0.309 0.691
E06.4 Drug-induced thyroiditis
0.000 0.309 0.691
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.309 0.691
E06.1 Subacute thyroiditis
0.000 0.309 0.691
E06.0 Acute thyroiditis
0.000 0.309 0.691
E10.6 With other specified complications
0.000 0.312 0.688
E10.8 With unspecified complications
0.000 0.321 0.679
E27.2 Addisonian crisis
0.000 0.347 0.653
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.349 0.651
E27.9 Disorder of adrenal gland, unspecified
0.000 0.350 0.650
E28 Ovarian dysfunction
0.000 0.351 0.649
E87.6 Hypokalaemia
0.000 0.375 0.625
E20 Hypoparathyroidism
0.000 0.375 0.624
E87.0 Hyperosmolality and hypernatraemia
0.000 0.379 0.621
E74 Other disorders of carbohydrate metabolism
0.000 0.382 0.618
E10.5 With peripheral circulatory complications
0.000 0.384 0.616
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.388 0.611
E45 Retarded development following protein-energy malnutrition
0.000 0.388 0.611
E43 Unspecified severe protein-energy malnutrition
0.000 0.388 0.611
E42 Marasmic kwashiorkor
0.000 0.388 0.611
E41 Nutritional marasmus
0.000 0.388 0.611
E40 Kwashiorkor
0.000 0.388 0.611
E73.8 Other lactose intolerance
0.000 0.394 0.605
E73.1 Secondary lactase deficiency
0.000 0.394 0.605
E73.0 Congenital lactase deficiency
0.000 0.394 0.605
E26 Hyperaldosteronism
0.000 0.396 0.604
E87.4 Mixed disorder of acid-base balance
0.000 0.403 0.597
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.407 0.593
E32 Diseases of thymus
0.000 0.407 0.593
E31 Polyglandular dysfunction
0.000 0.407 0.593
E30 Disorders of puberty, not elsewhere classified
0.000 0.407 0.593
E88.9 Metabolic disorder, unspecified
0.000 0.409 0.590
E88.8 Other specified metabolic disorders
0.000 0.409 0.590
E88.3 Tumour lysis syndrome
0.000 0.409 0.590
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.409 0.590
E80.7 Disorder of bilirubin metabolism, unspecified
0.000 0.414 0.586
E80.6 Other disorders of bilirubin metabolism
0.000 0.414 0.586
E80.5 Crigler-Najjar syndrome
0.000 0.414 0.586
E80.3 Defects of catalase and peroxydase
0.000 0.414 0.586
E80.1 Porphyria cutanea tarda
0.000 0.414 0.586
E80.0 Hereditary erythropoietic porphyria
0.000 0.414 0.586
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.421 0.579
E27.5 Adrenomedullary hyperfunction
0.000 0.421 0.579
E27.0 Other adrenocortical overactivity
0.000 0.421 0.579
E05.8 Other thyrotoxicosis
0.000 0.422 0.578
E88.2 Lipomatosis, not elsewhere classified
0.000 0.424 0.576
E27.8 Other specified disorders of adrenal gland
0.000 0.425 0.575
E24 Cushing's syndrome
0.000 0.433 0.567
E87.3 Alkalosis
0.000 0.434 0.566
E13 Other specified diabetes mellitus
0.000 0.437 0.562
E03.1 Congenital hypothyroidism without goitre
0.000 0.441 0.559
E07 Other disorders of thyroid
0.000 0.452 0.547
E80.2 Other porphyria
0.000 0.455 0.545
E28.2 Polycystic ovarian syndrome
0.000 0.459 0.541
E34 Other endocrine disorders
0.000 0.461 0.538
E25 Adrenogenital disorders
0.000 0.479 0.521
E23 Hypofunction and other disorders of pituitary gland
0.000 0.486 0.514
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.486 0.514
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.486 0.514
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.486 0.514
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.486 0.514
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.486 0.514
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.486 0.514
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.486 0.514
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.486 0.514
E12.9 Without complications
0.000 0.486 0.513
E12.8 With unspecified complications
0.000 0.486 0.513
E12.7 With multiple complications
0.000 0.486 0.513
E12.6 With other specified complications
0.000 0.486 0.513
E12.5 With peripheral circulatory complications
0.000 0.486 0.513
E12.4 With neurological complications
0.000 0.486 0.513
E12.3 With ophthalmic complications
0.000 0.486 0.513
E12.2 With renal complications
0.000 0.486 0.513
E12.1 With ketoacidosis
0.000 0.486 0.513
E12.0 With coma
0.000 0.486 0.513
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.488 0.512
E15 Nondiabetic hypoglycaemic coma
0.000 0.494 0.506
E50-E64 Other nutritional deficiencies
0.000 0.497 0.503
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.497 0.503
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.497 0.503
E70.3 Albinism
0.000 0.497 0.503
E70.2 Disorders of tyrosine metabolism
0.000 0.497 0.503
E70.1 Other hyperphenylalaninaemias
0.000 0.497 0.503
E70.0 Classical phenylketonuria
0.000 0.497 0.503
E71.3 Disorders of fatty-acid metabolism
0.000 0.497 0.503
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.497 0.503
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.497 0.503
E71.0 Maple-syrup-urine disease
0.000 0.497 0.503
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.497 0.503
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.497 0.503
E72.5 Disorders of glycine metabolism
0.000 0.497 0.503
E72.4 Disorders of ornithine metabolism
0.000 0.497 0.503
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.497 0.503
E72.2 Disorders of urea cycle metabolism
0.000 0.497 0.503
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.000 0.497 0.503
E72.0 Disorders of amino-acid transport
0.000 0.497 0.503
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.497 0.503
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.497 0.503
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.497 0.503
E76.2 Other mucopolysaccharidoses
0.000 0.497 0.503
E76.1 Mucopolysaccharidosis, type II
0.000 0.497 0.503
E76.0 Mucopolysaccharidosis, type I
0.000 0.497 0.503
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.497 0.503
E77.8 Other disorders of glycoprotein metabolism
0.000 0.497 0.503
E77.1 Defects in glycoprotein degradation
0.000 0.497 0.503
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.497 0.503
E84.9 Cystic fibrosis, unspecified
0.000 0.497 0.503
E84.8 Cystic fibrosis with other manifestations
0.000 0.497 0.503
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.497 0.503
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.497 0.503
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.503 0.497
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.503 0.497
E79.1 Lesch-Nyhan syndrome
0.000 0.503 0.497
E16 Other disorders of pancreatic internal secretion
0.000 0.504 0.496
E65-E68 Obesity and other hyperalimentation
0.000 0.507 0.493
E89.0 Postprocedural hypothyroidism
0.000 0.510 0.490
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.510 0.489
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.519 0.481
E20.9 Hypoparathyroidism, unspecified
0.000 0.521 0.479
E22 Hyperfunction of pituitary gland
0.000 0.525 0.475
E75.6 Lipid storage disorder, unspecified
0.000 0.533 0.467
E75.4 Neuronal ceroid lipofuscinosis
0.000 0.533 0.467
E75.3 Sphingolipidosis, unspecified
0.000 0.533 0.467
E75.2 Other sphingolipidosis
0.000 0.533 0.467
E75.1 Other gangliosidosis
0.000 0.533 0.467
E75.0 GM2 gangliosidosis
0.000 0.533 0.467
Z88.0 Personal history of allergy to penicillin
0.465 0.535 0.000
E28.9 Ovarian dysfunction, unspecified
0.000 0.535 0.465
E28.8 Other ovarian dysfunction
0.000 0.535 0.465
E28.1 Androgen excess
0.000 0.535 0.465
E28.0 Oestrogen excess
0.000 0.535 0.465
E20.8 Other hypoparathyroidism
0.000 0.552 0.448
E20.1 Pseudohypoparathyroidism
0.000 0.552 0.448
E20.0 Idiopathic hypoparathyroidism
0.000 0.552 0.448
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.557 0.443
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.557 0.443
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.557 0.443
E74.2 Disorders of galactose metabolism
0.000 0.557 0.443
E74.1 Disorders of fructose metabolism
0.000 0.557 0.443
E74.0 Glycogen storage disease
0.000 0.557 0.443
E26.0 Primary hyperaldosteronism
0.000 0.557 0.443
E44.1 Mild protein-energy malnutrition
0.000 0.561 0.438
E44.0 Moderate protein-energy malnutrition
0.000 0.561 0.438
E85 Amyloidosis
0.001 0.565 0.435
E26.9 Hyperaldosteronism, unspecified
0.000 0.567 0.433
E26.8 Other hyperaldosteronism
0.000 0.567 0.433
E26.1 Secondary hyperaldosteronism
0.000 0.567 0.433
E28.3 Primary ovarian failure
0.000 0.570 0.430
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.573 0.427
E21.3 Hyperparathyroidism, unspecified
0.000 0.574 0.426
E30.9 Disorder of puberty, unspecified
0.000 0.574 0.425
E30.8 Other disorders of puberty
0.000 0.574 0.425
E30.1 Precocious puberty
0.000 0.574 0.425
E30.0 Delayed puberty
0.000 0.574 0.425
E31.9 Polyglandular dysfunction, unspecified
0.000 0.574 0.425
E31.8 Other polyglandular dysfunction
0.000 0.574 0.425
E31.1 Polyglandular hyperfunction
0.000 0.574 0.425
E31.0 Autoimmune polyglandular failure
0.000 0.574 0.425
E32.9 Disease of thymus, unspecified
0.000 0.574 0.425
E32.8 Other diseases of thymus
0.000 0.574 0.425
E32.1 Abscess of thymus
0.000 0.574 0.425
E32.0 Persistent hyperplasia of thymus
0.000 0.574 0.425
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.574 0.425
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.574 0.425
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.574 0.425
E27.3 Drug-induced adrenocortical insufficiency
0.001 0.580 0.419
E75.5 Other lipid storage disorders
0.000 0.583 0.416
E24.9 Cushing's syndrome, unspecified
0.000 0.584 0.416
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.584 0.415
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.584 0.415
E89.5 Postprocedural testicular hypofunction
0.000 0.584 0.415
E89.4 Postprocedural ovarian failure
0.000 0.584 0.415
E89.1 Postprocedural hypoinsulinaemia
0.000 0.584 0.415
E07.8 Other specified disorders of thyroid
0.000 0.592 0.407
E23.6 Other disorders of pituitary gland
0.000 0.593 0.407
E24.8 Other Cushing's syndrome
0.000 0.594 0.406
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.594 0.406
E24.3 Ectopic ACTH syndrome
0.000 0.594 0.406
E24.1 Nelson's syndrome
0.000 0.594 0.406
E24.0 Pituitary-dependent Cushing's disease
0.000 0.594 0.406
E29 Testicular dysfunction
0.000 0.596 0.403
E13.8 With unspecified complications
0.000 0.596 0.403
E13.7 With multiple complications
0.000 0.596 0.403
E13.6 With other specified complications
0.000 0.596 0.403
E13.5 With peripheral circulatory complications
0.000 0.596 0.403
E13.4 With neurological complications
0.000 0.596 0.403
E13.3 With ophthalmic complications
0.000 0.596 0.403
E13.2 With renal complications
0.000 0.596 0.403
E13.1 With ketoacidosis
0.000 0.596 0.403
E13.0 With coma
0.000 0.596 0.403
E23.7 Disorder of pituitary gland, unspecified
0.000 0.597 0.403
E04 Other non-toxic goitre
0.000 0.600 0.400
E22.0 Acromegaly and pituitary gigantism
0.000 0.602 0.398
E07.1 Dyshormogenetic goitre
0.000 0.607 0.392
E07.0 Hypersecretion of calcitonin
0.000 0.607 0.392
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.607 0.393
E89.3 Postprocedural hypopituitarism
0.000 0.610 0.390
E34.8 Other specified endocrine disorders
0.000 0.613 0.386
E34.5 Androgen resistance syndrome
0.000 0.614 0.386
E34.4 Constitutional tall stature
0.000 0.614 0.386
E34.3 Short stature, not elsewhere classified
0.000 0.614 0.386
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.614 0.386
E34.1 Other hypersecretion of intestinal hormones
0.000 0.614 0.386
E14 Unspecified diabetes mellitus
0.000 0.615 0.385
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.617 0.383
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.624 0.376
E25.9 Adrenogenital disorder, unspecified
0.000 0.626 0.374
E25.8 Other adrenogenital disorders
0.000 0.626 0.374
E53 Deficiency of other B group vitamins
0.000 0.628 0.372
E65 Localised adiposity
0.000 0.631 0.369
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.631 0.369
E23.1 Drug-induced hypopituitarism
0.000 0.631 0.369
E24.2 Drug-induced Cushing's syndrome
0.000 0.632 0.368
E34.9 Endocrine disorder, unspecified
0.000 0.639 0.361
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.639 0.361
E63 Other nutritional deficiencies
0.000 0.639 0.361
E56 Other vitamin deficiencies
0.000 0.639 0.361
E51 Thiamine deficiency
0.000 0.639 0.361
E50 Vitamin A deficiency
0.000 0.639 0.361
E60 Dietary zinc deficiency
0.000 0.639 0.361
E59 Dietary selenium deficiency
0.000 0.639 0.361
E54 Ascorbic acid deficiency
0.000 0.639 0.361
E52 Niacin deficiency [pellagra]
0.000 0.639 0.361
E74.3 Other disorders of intestinal carbohydrate absorption
0.000 0.640 0.360
E34.0 Carcinoid syndrome
0.000 0.640 0.360
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.644 0.356
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.644 0.356
E16.4 Abnormal secretion of gastrin
0.000 0.644 0.356
E16.3 Increased secretion of glucagon
0.000 0.644 0.356
E04.0 Non-toxic diffuse goitre
0.000 0.645 0.355
E67 Other hyperalimentation
0.000 0.646 0.353
E68 Sequelae of hyperalimentation
0.000 0.646 0.353
G35 Multiple sclerosis
0.000 0.652 0.348
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.655 0.345
E21.2 Other hyperparathyroidism
0.000 0.655 0.345
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.659 0.341
E22.8 Other hyperfunction of pituitary gland
0.000 0.659 0.341
E23.2 Diabetes insipidus
0.000 0.662 0.338
E87.5 Hyperkalaemia
0.000 0.669 0.331
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.671 0.328
E58 Dietary calcium deficiency
0.000 0.678 0.322
E78.1 Pure hyperglyceridaemia
0.000 0.680 0.320
E61 Deficiency of other nutrient elements
0.000 0.683 0.317
E85.4 Organ-limited amyloidosis
0.001 0.686 0.314
E85.2 Heredofamilial amyloidosis, unspecified
0.001 0.688 0.312
E85.1 Neuropathic heredofamilial amyloidosis
0.001 0.688 0.312
E85.0 Nonneuropathic heredofamilial amyloidosis
0.001 0.688 0.312
E87.1 Hypo-osmolality and hyponatraemia
0.000 0.688 0.312
E16.2 Hypoglycaemia, unspecified
0.000 0.690 0.310
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.001 0.698 0.301
E21.4 Other specified disorders of parathyroid gland
0.000 0.699 0.301
E14.4 With neurological complications
0.000 0.703 0.296
E29.8 Other testicular dysfunction
0.000 0.710 0.289
E29.0 Testicular hyperfunction
0.000 0.710 0.289
E04.8 Other specified non-toxic goitre
0.000 0.713 0.287
E78.3 Hyperchylomicronaemia
0.000 0.718 0.282
E78.6 Lipoprotein deficiency
0.000 0.721 0.279
E53.8 Deficiency of other specified B group vitamins
0.000 0.722 0.278
E14.7 With multiple complications
0.000 0.724 0.276
E14.6 With other specified complications
0.000 0.724 0.276
E14.5 With peripheral circulatory complications
0.000 0.724 0.276
E14.0 With coma
0.000 0.724 0.276
E78.4 Other hyperlipidaemia
0.000 0.727 0.273
E55 Vitamin D deficiency
0.000 0.728 0.272
E85.8 Other amyloidosis
0.001 0.728 0.271
E14.8 With unspecified complications
0.000 0.729 0.271
E85.3 Secondary systemic amyloidosis
0.001 0.729 0.270
E14.1 With ketoacidosis
0.000 0.733 0.267
E53.1 Pyridoxine deficiency
0.000 0.733 0.266
E53.0 Riboflavin deficiency
0.000 0.733 0.266
E16.1 Other hypoglycaemia
0.000 0.734 0.265
E53.9 Vitamin B deficiency, unspecified
0.000 0.734 0.265
E78.2 Mixed hyperlipidaemia
0.000 0.740 0.259
E50.9 Vitamin A deficiency, unspecified
0.000 0.741 0.259
E50.8 Other manifestations of vitamin A deficiency
0.000 0.741 0.259
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.741 0.259
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.741 0.259
E50.5 Vitamin A deficiency with night blindness
0.000 0.741 0.259
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.741 0.259
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.741 0.259
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.741 0.259
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.741 0.259
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.741 0.259
E51.9 Thiamine deficiency, unspecified
0.000 0.741 0.259
E51.8 Other manifestations of thiamine deficiency
0.000 0.741 0.259
E51.2 Wernicke's encephalopathy
0.000 0.741 0.259
E51.1 Beriberi
0.000 0.741 0.259
E56.9 Vitamin deficiency, unspecified
0.000 0.741 0.259
E56.8 Deficiency of other vitamins
0.000 0.741 0.259
E56.1 Deficiency of vitamin K
0.000 0.741 0.259
E56.0 Deficiency of vitamin E
0.000 0.741 0.259
E63.9 Nutritional deficiency, unspecified
0.000 0.741 0.259
E63.8 Other specified nutritional deficiencies
0.000 0.741 0.259
E63.1 Imbalance of constituents of food intake
0.000 0.741 0.259
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.741 0.259
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.741 0.259
E64.8 Sequelae of other nutritional deficiencies
0.000 0.741 0.259
E64.3 Sequelae of rickets
0.000 0.741 0.259
E64.2 Sequelae of vitamin C deficiency
0.000 0.741 0.259
E64.1 Sequelae of vitamin A deficiency
0.000 0.741 0.259
E64.0 Sequelae of protein-energy malnutrition
0.000 0.741 0.259
E67.8 Other specified hyperalimentation
0.000 0.746 0.253
E67.3 Hypervitaminosis D
0.000 0.746 0.253
E67.2 Megavitamin-B6 syndrome
0.000 0.746 0.253
E67.1 Hypercarotenaemia
0.000 0.746 0.253
E67.0 Hypervitaminosis A
0.000 0.746 0.253
E22.1 Hyperprolactinaemia
0.001 0.749 0.251
E13.9 Without complications
0.001 0.750 0.250
E14.2 Withrenal complications
0.000 0.751 0.249
E14.3 With ophthalmic complications
0.000 0.754 0.246
E29.9 Testicular dysfunction, unspecified
0.001 0.755 0.245
E61.9 Deficiency of nutrient element, unspecified
0.000 0.773 0.227
E61.8 Deficiency of other specified nutrient elements
0.000 0.773 0.227
E61.7 Deficiency of multiple nutrient elements
0.000 0.773 0.227
E61.6 Vanadium deficiency
0.000 0.773 0.227
E61.5 Molybdenum deficiency
0.000 0.773 0.227
E61.4 Chromium deficiency
0.000 0.773 0.227
E61.3 Manganese deficiency
0.000 0.773 0.227
E61.0 Copper deficiency
0.000 0.773 0.227
E11 Non-insulin-dependent diabetes mellitus
0.000 0.775 0.225
E04.1 Non-toxic single thyroid nodule
0.000 0.784 0.216
E85.9 Amyloidosis, unspecified
0.001 0.787 0.212
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.789 0.211
E61.2 Magnesium deficiency
0.000 0.791 0.209
E61.1 Iron deficiency
0.000 0.794 0.206
E89.2 Postprocedural hypoparathyroidism
0.001 0.799 0.199
E11.1 With ketoacidosis
0.000 0.800 0.199
E55.0 Rickets, active
0.000 0.805 0.195
E11.3 With ophthalmic complications
0.000 0.808 0.192
E07.9 Disorder of thyroid, unspecified
0.000 0.811 0.188
E23.0 Hypopituitarism
0.000 0.813 0.186
E29.1 Testicular hypofunction
0.001 0.815 0.185
E83 Disorders of mineral metabolism
0.000 0.824 0.176
E11.2 With renal complications
0.000 0.833 0.167
E11.8 With unspecified complications
0.000 0.835 0.165
E11.7 With multiple complications
0.000 0.839 0.161
G35-G37 Demyelinating diseases of the central nervous system
0.000 0.848 0.152
E11.0 With coma
0.000 0.858 0.142
E83.3 Disorders of phosphorus metabolism
0.000 0.864 0.136
E78.8 Other disorders of lipoprotein metabolism
0.001 0.866 0.133
E04.9 Non-toxic goitre, unspecified
0.000 0.870 0.130
E83.9 Disorder of mineral metabolism, unspecified
0.000 0.874 0.126
E83.8 Other disorders of mineral metabolism
0.000 0.874 0.126
E83.2 Disorders of zinc metabolism
0.000 0.874 0.126
E83.0 Disorders of copper metabolism
0.000 0.874 0.126
E04.2 Non-toxic multinodular goitre
0.000 0.880 0.120
G37 Other demyelinating diseases of central nervous system
0.000 0.888 0.112
E11.6 With other specified complications
0.000 0.890 0.110
G36 Other acute disseminated demyelination
0.000 0.891 0.109
E55.9 Vitamin D deficiency, unspecified
0.000 0.894 0.106
E11.5 With peripheral circulatory complications
0.000 0.897 0.103
E14.9 Without complications
0.000 0.909 0.091
G37.9 Demyelinating disease of central nervous system, unspecified
0.000 0.912 0.088
E66 Obesity
0.000 0.917 0.083
G37.5 Concentric sclerosis [Balo]
0.000 0.919 0.081
G37.4 Subacute necrotising myelitis
0.000 0.919 0.081
G37.2 Central pontine myelinolysis
0.000 0.919 0.081
G37.1 Central demyelination of corpus callosum
0.000 0.919 0.081
G37.0 Diffuse sclerosis
0.000 0.919 0.081
G37.8 Other specified demyelinating diseases of central nervous system
0.000 0.920 0.080
E83.4 Disorders of magnesium metabolism
0.000 0.921 0.079
G36.9 Acute disseminated demyelination, unspecified
0.000 0.922 0.078
G36.8 Other specified acute disseminated demyelination
0.000 0.922 0.078
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.000 0.922 0.078
G36.0 Neuromyelitis optica [Devic]
0.000 0.922 0.078
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.000 0.923 0.076
E21.0 Primary hyperparathyroidism
0.001 0.927 0.072
E66.1 Drug-induced obesity
0.000 0.940 0.060
E83.1 Disorders of iron metabolism
0.000 0.942 0.058
M06.9 Rheumatoid arthritis, unspecified
0.000 0.946 0.054
E66.8 Other obesity
0.000 0.947 0.053
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.948 0.052
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.948 0.052
L40.9 Psoriasis, unspecified
0.049 0.951 0.000
Z93.2 Ileostomy status
0.000 0.954 0.046
N41.9 Inflammatory disease of prostate, unspecified
0.045 0.955 0.000
E66.2 Extreme obesity with alveolar hypoventilation
0.000 0.955 0.045
E66.0 Obesity due to excess calories
0.000 0.956 0.044
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.956 0.044
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.000 0.956 0.044
M06.98 Rheumatoid arthritis, unspecified (Other)
0.000 0.956 0.044
M06 Other rheumatoid arthritis
0.000 0.959 0.041
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.960 0.040
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.000 0.960 0.040
M06.0 Seronegative rheumatoid arthritis
0.000 0.961 0.039
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.000 0.961 0.039
M06.00 Seronegative rheumatoid arthritis (Multiple sites)
0.000 0.963 0.036
D69 Purpura and other haemorrhagic conditions
0.000 0.964 0.036
D61.9 Aplastic anaemia, unspecified
0.000 0.965 0.035
M06.09 Seronegative rheumatoid arthritis (Site unspecified)
0.000 0.965 0.035
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.000 0.965 0.035
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.000 0.965 0.034
D69.6 Thrombocytopenia, unspecified
0.000 0.966 0.034
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.967 0.033
D68 Other coagulation defects
0.000 0.968 0.032
D69.3 Idiopathic thrombocytopenic purpura
0.000 0.968 0.032
D69.5 Secondary thrombocytopenia
0.000 0.968 0.032
D61 Other aplastic anaemias
0.000 0.968 0.032
N41 Inflammatory diseases of prostate
0.030 0.970 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.000 0.970 0.030
D60-D64 Aplastic and other anaemias
0.000 0.970 0.030
M06.8 Other specified rheumatoid arthritis
0.000 0.970 0.030
M06.2 Rheumatoid bursitis
0.000 0.970 0.030
M06.1 Adult-onset Still's disease
0.000 0.970 0.030
N41.0 Acute prostatitis
0.030 0.970 0.000
M06.3 Rheumatoid nodule
0.000 0.971 0.029
D68.9 Coagulation defect, unspecified
0.000 0.972 0.028
M06.08 Seronegative rheumatoid arthritis (Other)
0.000 0.972 0.028
M06.07 Seronegative rheumatoid arthritis (Ankle and foot)
0.000 0.972 0.028
M06.05 Seronegative rheumatoid arthritis (Pelvic region and thigh)
0.000 0.972 0.028
M06.04 Seronegative rheumatoid arthritis (Hand)
0.000 0.972 0.028
M06.03 Seronegative rheumatoid arthritis (Forearm)
0.000 0.972 0.028
M06.02 Seronegative rheumatoid arthritis (Upper arm)
0.000 0.972 0.028
D68.2 Hereditary deficiency of other clotting factors
0.000 0.972 0.028
E11.4 With neurological complications
0.001 0.972 0.027
D69.4 Other primary thrombocytopenia
0.000 0.972 0.028
M06.06 Seronegative rheumatoid arthritis (Lower leg)
0.000 0.974 0.026
D69.8 Other specified haemorrhagic conditions
0.000 0.974 0.026
D69.2 Other nonthrombocytopenic purpura
0.000 0.974 0.026
D69.1 Qualitative platelet defects
0.000 0.974 0.026
D65 Disseminated intravascular coagulation [defibrination syndrome]
0.000 0.974 0.026
M06.4 Inflammatory polyarthropathy
0.000 0.974 0.026
D69.0 Allergic purpura
0.000 0.975 0.025
D64 Other anaemias
0.000 0.975 0.025
D67 Hereditary factor IX deficiency
0.000 0.975 0.025
D55-D59 Haemolytic anaemias
0.000 0.975 0.025
D68.0 Von Willebrand's disease
0.000 0.975 0.025
N92.3 Ovulation bleeding
0.025 0.975 0.000
D68.6 Other Thrombophilia
0.000 0.975 0.024
D70-D77 Other diseases of blood and blood-forming organs
0.000 0.975 0.025
D50-D53 Nutritional anaemias
0.000 0.976 0.024
D68.4 Acquired coagulation factor deficiency
0.000 0.977 0.023
D68.1 Hereditary factor XI deficiency
0.000 0.977 0.023
D61.8 Other specified aplastic anaemias
0.000 0.977 0.023
D61.3 Idiopathic aplastic anaemia
0.000 0.977 0.023
D61.2 Aplastic anaemia due to other external agents
0.000 0.977 0.023
D61.0 Constitutional aplastic anaemia
0.000 0.977 0.023
N92.0 Excessive and frequent menstruation with regular cycle
0.023 0.977 0.000
D68.3 Haemorrhagic disorder due to circulating anticoagulants
0.000 0.977 0.023
D66 Hereditary factor VIII deficiency
0.000 0.978 0.022

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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